Scholars@Duke
Emily R. Derbyshire

Emily R. Derbyshire

Pelham Wilder Distinguished Professor of Chemistry
Chemistry
3218 French Science Center, Durham, NC 27708

Featured Works

Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death.

Journal article eLife · September 2020 Featured Publication Phosphatidylinositol 3-phosphate (PI(3)P) levels in Plasmodium falciparum correlate with tolerance to cellular stresses caused by artemisinin and environmental factors. However, PI(3)P function during the Plasmodium stress response was unknow ... Full text Cite

A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity.

Journal article Cell chemical biology · July 2020 Featured Publication Advances in infectious disease control strategies through genetic manipulation of insect microbiomes have heightened interest in microbially produced small molecules within mosquitoes. Herein, 33 mosquito-associated bacterial genomes were mined and over 70 ... Full text Cite

Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3.

Journal article Cell chemical biology · June 2020 Featured Publication Plasmodium vivax infects hepatocytes to form schizonts that cause blood infection, or dormant hypnozoites that can persist for months in the liver before leading to relapsing blood infections. The molecular processes that drive P. vivax schizont and hypnoz ... Full text Cite

Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection.

Journal article Cell chemical biology · September 2019 Featured Publication Plasmodium parasites undergo an obligatory and asymptomatic developmental stage within the liver before infecting red blood cells to cause malaria. The hijacked host pathways critical to parasite infection during this hepatic phase remain poorly understood ... Full text Cite