Emily O'Brien | Scholars@Duke

Emily O'Brien
Assistant Professor in Population Health Sciences

I am an epidemiologist and health services researcher at the Duke Clinical Research Institute. My research focuses on comparative effectiveness, patient-centered outcomes, and pragmatic health services research in cardiovascular and pulmonary disease.

Areas of expertise: Epidemiology, Health Services Research, and Clinical Decision Sciences

Current Appointments & Affiliations

Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2018
Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2013

Contact Information

2400 Pratt Street, Duke Clin. Research Inst. 6th Floor, Durham, NC 27707
emily.obrien@duke.edu (919) 668-0670

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina at Chapel Hill 2012
Duke Appointment History
- Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2017 - 2018
- Assistant Professor in Medicine, Medicine, Clinical Pharmacology, Medicine 2015 - 2017
- Medical Instructor in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2013 - 2015
- Instructor Temporary in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2013
Recognition
In the News
- NOV 14, 2016 Duke Health News
  
  Nearly A Third of Newly Diagnosed AFib Patients Don't Understand Stroke Risk
Research
Selected Grants
- PROSPER awarded by Patient-Centered Outcomes Research Institute 2013 - 2019
- Methodology for Linking Clinical and Administrative Databases awarded by Patient-Centered Outcomes Research Institute 2014 - 2018
- A Collaboration for Improving Outcomes of African Americans with Heart Failure awarded by National Institutes of Health 2013 - 2018
- Extraction Vs Capping Pacing and Defibrillator Leads awarded by Spectranetics 2015 - 2016
- PROSPER awarded by Patient-Centered Outcomes Research Institute 2013 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - O'Brien, EC, Holmes, DN, Thomas, L, Singer, DE, Fonarow, GC, Mahaffey, KW, Kowey, PR, Hylek, EM, Pokorney, SD, Ansell, JE, Pencina, MJ, Peterson, ED, Piccini, JP, and ORBIT-AF Patients & Investigators, . "Incremental prognostic value of renal function for stroke prediction in atrial fibrillation.(Accepted)" International Journal of Cardiology 274 (January 2019): 152-157. Full Text
  - O'Brien, EC, Li, S, Thomas, L, Wang, TY, Roe, MT, and Peterson, ED. "The impact of clinical vs administrative claims coding on hospital risk-adjusted outcomes." Clinical Cardiology 41, no. 9 (September 22, 2018): 1225-1231. Full Text
  - Kaufman, BG, Klemish, D, Kassner, CT, Reiter, JP, Li, F, Harker, M, O'Brien, EC, Taylor, DH, and Bhavsar, NA. "Predicting Length of Hospice Stay: An Application of Quantile Regression." Journal of Palliative Medicine 21, no. 8 (August 2018): 1131-1136. Full Text
  - Kelly, JP, Greiner, M, Soliman, EZ, Randolph, TC, Thomas, KL, Dunlay, SM, Curtis, LH, O'Brien, EC, and Mentz, RJ. "Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study)." The American Journal of Cardiology 122, no. 2 (July 2018): 340-346. Full Text
  - Thomas, LE, O'Brien, EC, Piccini, JP, D'Agostino, RB, and Pencina, MJ. "Application of net reclassification index to non-nested and point-based risk prediction models: a review." European Heart Journal (June 27, 2018). Full Text
  - O'Brien, EC, Holmes, DN, Thomas, L, Fonarow, GC, Kowey, PR, Ansell, JE, Mahaffey, KW, Gersh, BJ, Peterson, ED, Piccini, JP, and Hylek, EM. "Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT-AF." Journal of the American Heart Association 7, no. 12 (June 9, 2018). Full Text
  - Greene, SJ, O'Brien, EC, Mentz, RJ, Luo, N, Hardy, NC, Laskey, WK, Heidenreich, PA, Chang, C-L, Turner, SJ, Yancy, CW, Hernandez, AF, Curtis, LH, Peterson, PN, Fonarow, GC, and Hammill, BG. "Home-Time After Discharge Among Patients Hospitalized With Heart Failure." Journal of the American College of Cardiology 71, no. 23 (June 2018): 2643-2652. Full Text
  - Luo, N, Ballew, NG, O'Brien, EC, Greiner, MA, Peterson, PN, Hammill, BG, Hardy, NC, Laskey, WK, Heidenreich, PA, Chang, C-L, Hernandez, AF, Curtis, LH, Mentz, RJ, and Fonarow, GC. "Early impact of guideline publication on angiotensin-receptor neprilysin inhibitor use among patients hospitalized for heart failure." American Heart Journal 200 (June 2018): 134-140. Full Text
  - Mentz, RJ, Greiner, MA, Muntner, P, Shimbo, D, Sims, M, Spruill, TM, Banahan, BF, Wang, W, Mwasongwe, S, Winters, K, Correa, A, Curtis, LH, and O'Brien, EC. "Intentional and unintentional medication non-adherence in African Americans: Insights from the Jackson Heart Study." American Heart Journal 200 (June 2018): 51-59. Full Text
  - O'Brien, EC, Holmes, DN, Thomas, LE, Fonarow, GC, Allen, LA, Gersh, BJ, Kowey, PR, Singer, DE, Ezekowitz, MD, Naccarelli, GV, Ansell, JE, Chan, PS, Mahaffey, KW, Go, AS, Freeman, JV, Reiffel, JA, Peterson, ED, Piccini, JP, and Hylek, EM. "Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients with Atrial Fibrillation." Circulation (April 20, 2018). Full Text
  - Foraker, RE, Guha, A, Chang, H, O'Brien, EC, Bower, JK, Crouser, ED, Rosamond, WD, and Raman, SV. "Survival After MI in a Community Cohort Study: Contribution of Comorbidities in NSTEMI." Global Heart 13, no. 1 (March 5, 2018): 13-18. Full Text
  - Bath, PM, Woodhouse, LJ, Appleton, JP, Beridze, M, Christensen, H, Dineen, RA, Duley, L, England, TJ, Flaherty, K, Havard, D, Heptinstall, S, James, M, Krishnan, K, Markus, HS, Montgomery, AA, Pocock, SJ, Randall, M, Ranta, A, Robinson, TG, Scutt, P, Venables, GS, Sprigg, N, and TARDIS Investigators, . "Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial." Lancet (London, England) 391, no. 10123 (March 2018): 850-859. Full Text
  - Kaufman, BG, Kim, S, Pieper, K, Allen, LA, Gersh, BJ, Naccarelli, GV, Ezekowitz, MD, Fonarow, GC, Mahaffey, KW, Singer, DE, Chan, PS, Freeman, JV, Ansell, J, Kowey, PR, Rieffel, JA, Piccini, J, Peterson, E, and O'Brien, EC. "Disease understanding in patients newly diagnosed with atrial fibrillation." Heart (British Cardiac Society) 104, no. 6 (March 2018): 494-501. Full Text
  - Amrock, SM, Duell, PB, Knickelbine, T, Martin, SS, O'Brien, EC, Watson, KE, Mitri, J, Kindt, I, Shrader, P, Baum, SJ, Hemphill, LC, Ahmed, CD, Andersen, RL, Kullo, IJ, McCann, D, Larry, JA, Murray, MF, Fishberg, R, Guyton, JR, Wilemon, K, Roe, MT, Rader, DJ, Ballantyne, CM, Underberg, JA, Thompson, P, Duffy, D, Linton, MF, Shapiro, MD, Moriarty, PM, Knowles, JW, and Ahmad, ZS. "Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry." Atherosclerosis 267 (December 2017): 19-26. Full Text
  - Kaufman, BG, Spivack, BS, Stearns, SC, Song, PH, and O'Brien, EC. "Impact of Accountable Care Organizations on Utilization, Care, and Outcomes: A Systematic Review." Medical Care Research and Review : Mcrr (December 2017): 1077558717745916-null. Full Text
  - Van Houtven, CH, Miller, KEM, O'Brien, EC, Wolff, JL, Lindquist, J, Kabat, M, Campbell-Kotler, M, Henius, J, and Voils, CI. "Development and Initial Validation of the Caregiver Perceptions About Communication With Clinical Team Members (CAPACITY) Measure." Medical Care Research and Review : Mcrr (December 2017): 1077558717747985-null. Full Text
  - Luo, N, Mentz, RJ, and O’Brien, EC. "Reply." JACC: Heart Failure 5, no. 9 (September 2017): 689-689. Full Text
  - Parikh, KS, Greiner, MA, Wang, W, Min, Y-I, Correa, A, Banahan, BF, Curtis, LH, Hernandez, AF, O'Brien, EC, and Mentz, RJ. "Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries." Epidemiology (Cambridge, Mass.) 28, no. 5 (September 2017): 740-746. Full Text
  - Wang, T, O'Brien, EC, Rogers, JG, Jacoby, DL, Chen, ME, Testani, JM, Bowles, DE, Milano, CA, Felker, GM, Patel, CB, Bonde, PN, and Ahmad, T. "Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support." Asaio Journal (American Society for Artificial Internal Organs : 1992) 63, no. 5 (September 2017): 536-541. Full Text
  - Tajeu, GS, Booth, JN, Colantonio, LD, Gottesman, RF, Howard, G, Lackland, DT, O'Brien, EC, Oparil, S, Ravenell, J, Safford, MM, Seals, SR, Shimbo, D, Shea, S, Spruill, TM, Tanner, RM, and Muntner, P. "Incident Cardiovascular Disease Among Adults With Blood Pressure <140/90 mm Hg." Circulation 136, no. 9 (August 2017): 798-812. Full Text
  - Steinberg, BA, Shrader, P, Thomas, L, Ansell, J, Fonarow, GC, Gersh, BJ, Hylek, E, Kowey, PR, Mahaffey, KW, O'Brien, EC, Singer, DE, Peterson, ED, Piccini, JP, and Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators and Patients, . "Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)." American Heart Journal 189 (July 2017): 40-47. Full Text
  - Anderson, ML, Peragallo Urrutia, R, O'Brien, EC, Allen LaPointe, NM, Christian, AJ, Kaltenbach, LA, Webb, LE, Alexander, AM, Saha Chaudhuri, P, Crawford, J, Wayte, P, and Peterson, ED. "Outcomes of a multi-community hypertension implementation study: the American Heart Association's Check. Change. Control. program." Journal of Clinical Hypertension (Greenwich, Conn.) 19, no. 5 (May 2017): 479-487. Full Text
  - Dunlay, SM, Lippmann, SJ, Greiner, MA, O'Brien, EC, Chamberlain, AM, Mentz, RJ, and Sims, M. "Perceived Discrimination and Cardiovascular Outcomes in Older African Americans: Insights From the Jackson Heart Study." Mayo Clinic proceedings 92, no. 5 (May 2017): 699-709. Full Text
  - Katz, DF, Maddox, TM, Turakhia, M, Gehi, A, O'Brien, EC, Lubitz, SA, Turchin, A, Doros, G, Lei, L, Varosy, P, Marzec, L, and Hsu, JC. "Contemporary Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Low to Moderate Risk of Stroke After Guideline-Recommended Change in Use of the CHADS2 to the CHA2DS2-VASc Score for Thromboembolic Risk Assessment: Analysis From the National Cardiovascular Data Registry's Outpatient Practice Innovation and Clinical Excellence Atrial Fibrillation Registry." Circulation. Cardiovascular Quality and Outcomes 10, no. 5 (May 2017). Full Text
  - Luo, N, Fonarow, GC, Lippmann, SJ, Mi, X, Heidenreich, PA, Yancy, CW, Greiner, MA, Hammill, BG, Hardy, NC, Turner, SJ, Laskey, WK, Curtis, LH, Hernandez, AF, Mentz, RJ, and O'Brien, EC. "Early Adoption of Sacubitril/Valsartan for Patients With Heart Failure With Reduced Ejection Fraction: Insights From Get With the Guidelines-Heart Failure (GWTG-HF)." Jacc. Heart Failure 5, no. 4 (April 2017): 305-309. Full Text
  - Xian, Y, O'Brien, EC, Liang, L, Xu, H, Schwamm, LH, Fonarow, GC, Bhatt, DL, Smith, EE, Olson, DM, Maisch, L, Hannah, D, Lindholm, B, Lytle, BL, Pencina, MJ, Hernandez, AF, and Peterson, ED. "Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation." Jama 317, no. 10 (March 2017): 1057-1067. Full Text
  - O'Brien, EC, Wu, J, Zhao, X, Schulte, PJ, Fonarow, GC, Hernandez, AF, Schwamm, LH, Peterson, ED, Bhatt, DL, and Smith, EE. "Healthcare Resource Availability, Quality of Care, and Acute Ischemic Stroke Outcomes." Journal of the American Heart Association 6, no. 2 (February 3, 2017). Full Text
  - Gehi, AK, O'Brien, E, Pathak, RK, Sanders, P, Kennedy, KF, Virani, SS, Masoudi, FA, and Maddox, TM. "Implications of the LEGACY trial on US Atrial Fibrillation Patients: An NCDR Research to Practice (R2P) Project." The American journal of cardiology 119, no. 4 (February 2017): 579-584. Full Text
  - Parikh, KS, Greiner, MA, Suzuki, T, DeVore, AD, Blackshear, C, Maher, JF, Curtis, LH, Hernandez, AF, O'Brien, EC, and Mentz, RJ. "Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study." Jama Cardiology 2, no. 2 (February 2017): 172-180. Full Text
  - Parikh, KS, Greiner, MA, Suzuki, T, DeVore, AD, Blackshear, C, Maher, JF, Curtis, LH, Hernandez, AF, O'Brien, EC, and Mentz, RJ. "Resting Heart Rate and Long-term Outcomes Among the African American Population Insights From the Jackson Heart Study." JAMA CARDIOLOGY 2, no. 2 (February 2017): 172-180. Full Text Link to Item
  - Randolph, TC, Greiner, MA, Egwim, C, Hernandez, AF, Thomas, KL, Curtis, LH, Muntner, P, Wang, W, Mentz, RJ, and O'Brien, EC. "Associations Between Blood Pressure and Outcomes Among Blacks in the Jackson Heart Study." Journal of the American Heart Association 5, no. 12 (December 7, 2016). Full Text
  - Ahmad, ZS, Andersen, RL, Andersen, LH, O'Brien, EC, Kindt, I, Shrader, P, Vasandani, C, Newman, CB, deGoma, EM, Baum, SJ, Hemphill, LC, Hudgins, LC, Ahmed, CD, Kullo, IJ, Gidding, SS, Duffy, D, Neal, W, Wilemon, K, Roe, MT, Rader, DJ, Ballantyne, CM, Linton, MF, Duell, PB, Shapiro, MD, Moriarty, PM, and Knowles, JW. "US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry." JOURNAL OF CLINICAL LIPIDOLOGY 10, no. 5 (October 2016): 1223-1229. Full Text Link to Item
  - O'Brien, EC, Xian, Y, Xu, H, Wu, J, Saver, JL, Smith, EE, Schwamm, LH, Peterson, ED, Reeves, MJ, Bhatt, DL, Maisch, L, Hannah, D, Lindholm, B, Olson, D, Prvu Bettger, J, Pencina, M, Hernandez, AF, and Fonarow, GC. "Hospital Variation in Home-Time After Acute Ischemic Stroke: Insights From the PROSPER Study (Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research)." Stroke 47, no. 10 (October 2016): 2627-2633. Full Text
  - Ahmad, ZS, Andersen, RL, Andersen, LH, O'Brien, EC, Kindt, I, Shrader, P, Vasandani, C, Newman, CB, deGoma, EM, Baum, SJ, Hemphill, LC, Hudgins, LC, Ahmed, CD, Kullo, IJ, Gidding, SS, Duffy, D, Neal, W, Wilemon, K, Roe, MT, Rader, DJ, Ballantyne, CM, Linton, MF, Duell, PB, Shapiro, MD, Moriarty, PM, and Knowles, JW. "US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry." Journal of Clinical Lipidology 10, no. 5 (September 2016): 1223-1229. Full Text
  - Krishnamoorthy, A, Greiner, MA, Bertoni, AG, Eapen, ZJ, O'Brien, EC, Curtis, LH, Hernandez, AF, and Mentz, RJ. "The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study." Journal of Cardiac Failure 22, no. 8 (August 2016): 589-597. Full Text
  - Foraker, RE, Greiner, M, Sims, M, Tucker, KL, Towfighi, A, Bidulescu, A, Shoben, AB, Smith, S, Talegawkar, S, Blackshear, C, Wang, W, Hardy, NC, and O'Brien, E. "Comparison of risk scores for the prediction of stroke in African Americans: Findings from the Jackson Heart Study." American Heart Journal 177 (July 2016): 25-32. Full Text
  - Mentz, RJ, and O'Brien, EC. "Can 2 Pills a Day Keep Readmission Away?: Sacubitril/Valsartan to Reduce 30-Day Heart Failure Readmissions." Journal of the American College of Cardiology 68, no. 3 (July 2016): 249-251. Full Text
  - deGoma, EM, Ahmad, ZS, O'Brien, EC, Kindt, I, Shrader, P, Newman, CB, Pokharel, Y, Baum, SJ, Hemphill, LC, Hudgins, LC, Ahmed, CD, Gidding, SS, Duffy, D, Neal, W, Wilemon, K, Roe, MT, Rader, DJ, Ballantyne, CM, Linton, MF, Duell, PB, Shapiro, MD, Moriarty, PM, and Knowles, JW. "Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry." Circulation. Cardiovascular Genetics 9, no. 3 (June 2016): 240-249. Full Text
  - O'Brien, EC, Kim, S, Thomas, L, Fonarow, GC, Kowey, PR, Mahaffey, KW, Gersh, BJ, Piccini, JP, and Peterson, ED. "Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry." Journal of the American Heart Association 5, no. 5 (May 4, 2016). Full Text Open Access Copy
  - Pokorney, SD, O'Brien, EC, and Granger, CB. "Assessing generalizability of trial results in general practice." European heart journal 37, no. 14 (April 2016): 1154-1157. Full Text
  - Fonarow, GC, Liang, L, Thomas, L, Xian, Y, Saver, JL, Smith, EE, Schwamm, LH, Peterson, ED, Hernandez, AF, Duncan, PW, O'Brien, EC, Bushnell, C, and Prvu Bettger, J. "Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries." Stroke 47, no. 3 (March 2016): 836-842. Full Text
  - Mentz, RJ, Hernandez, AF, Berdan, LG, Rorick, T, O'Brien, EC, Ibarra, JC, Curtis, LH, and Peterson, ED. "Good Clinical Practice Guidance and Pragmatic Clinical Trials: Balancing the Best of Both Worlds." Circulation 133, no. 9 (March 2016): 872-880. (Review) Full Text
  - O'Brien, EC, Wu, J, Schulte, PJ, Christian, A, Laskey, W, Bhatt, DL, Peterson, ED, Hernandez, AF, and Fonarow, GC. "Statin use, intensity, and 3-year clinical outcomes among older patients with coronary artery disease." American Heart Journal 173 (March 2016): 27-34. Full Text
  - O'Brien, EC, and Thomas, LE. "Untangling the paradox: Obesity as prognostic marker in prevalent cardiovascular disease." American heart journal 172 (February 2016): 170-172. Full Text
  - O'Brien, EC, Durheim, MT, Gamerman, V, Garfinkel, S, Anstrom, KJ, Palmer, SM, and Conoscenti, CS. "Rationale for and design of the Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) registry." Bmj Open Respiratory Research 3, no. 1 (January 11, 2016): e000108-null. Full Text
  - Mentz, RJ, and O'Brien, EC. "Air Pollution in Patients With Heart Failure: Lessons From a Mechanistic Pilot Study of a Filter Intervention." JACC. Heart failure 4, no. 1 (January 2016): 65-67. Full Text
  - O'Brien, EC, Simon, DJN, Thomas, LE, Hylek, EM, Gersh, BJ, Ansell, JE, Kowey, PR, Mahaffey, KW, Chang, P, Fonarow, GC, Pencina, MJ, Piccini, JP, and Peterson, ED. "The ORBIT bleeding score: A simple bedside score to assess bleeding risk in atrial fibrillation." European Heart Journal 36, no. 46 (December 7, 2015): 3258-3264. Full Text
  - O'Brien, EC, Simon, DN, Thomas, LE, Hylek, EM, Gersh, BJ, Ansell, JE, Kowey, PR, Mahaffey, KW, Chang, P, Fonarow, GC, Pencina, MJ, Piccini, JP, and Peterson, ED. "The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation." European Heart Journal 36, no. 46 (December 2015): 3258-3264. Full Text Open Access Copy
  - O'Brien, EC, Greiner, MA, Sims, M, Hardy, NC, Wang, W, Shahar, E, Hernandez, AF, and Curtis, LH. "Depressive Symptoms and Risk of Cardiovascular Events in Blacks: Findings From the Jackson Heart Study." Circulation. Cardiovascular quality and outcomes 8, no. 6 (November 17, 2015): 552-559. Full Text
  - O'Brien, EC, Greiner, MA, Xian, Y, Fonarow, GC, Olson, DM, Schwamm, LH, Bhatt, DL, Smith, EE, Maisch, L, Hannah, D, Lindholm, B, Peterson, ED, Pencina, MJ, and Hernandez, AF. "Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study." Circulation 132, no. 15 (October 2015): 1404-1413. Full Text
  - O'Brien, EC, Zhao, X, Fonarow, GC, Schulte, PJ, Dai, D, Smith, EE, Schwamm, LH, Bhatt, DL, Xian, Y, Saver, JL, Reeves, MJ, Peterson, ED, and Hernandez, AF. "Quality of Care and Ischemic Stroke Risk After Hospitalization for Transient Ischemic Attack: Findings From Get With The Guidelines-Stroke." Circulation. Cardiovascular Quality and Outcomes 8, no. 6 Suppl 3 (October 2015): S117-S124. Full Text
  - Shah, BR, O'Brien, EC, Roe, MT, Chen, AY, and Peterson, ED. "The association of in-hospital guideline adherence and longitudinal postdischarge mortality in older patients with non-ST-segment elevation myocardial infarction." American Heart Journal 170, no. 2 (August 2015): 273-280.e1. Full Text
  - Xian, Y, Wu, J, O'Brien, EC, Fonarow, GC, Olson, DM, Schwamm, LH, Bhatt, DL, Smith, EE, Suter, RE, Hannah, D, Lindholm, B, Maisch, L, Greiner, MA, Lytle, BL, Pencina, MJ, Peterson, ED, and Hernandez, AF. "Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) study." Bmj (Clinical Research Ed.) 351 (July 31, 2015): h3786-null. Full Text
  - Ahmad, T, O'Brien, EC, Schulte, PJ, Stevens, SR, Fiuzat, M, Kitzman, DW, Adams, KF, Kraus, WE, Piña, IL, Donahue, MP, Zannad, F, Whellan, DJ, O'Connor, CM, and Felker, GM. "Evaluation of the Incremental Prognostic Utility of Increasingly Complex Testing in Chronic Heart Failure." Circulation. Heart Failure 8, no. 4 (July 2015): 709-716. Full Text
  - O'Brien, EC, McCoy, LA, Thomas, L, Peterson, ED, and Wang, TY. "Patient adherence to generic versus brand statin therapy after acute myocardial infarction: Insights from the Can Rapid Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines Registry." American Heart Journal 170, no. 1 (July 2015): 55-61. Full Text
  - Xian, Y, O'Brien, EC, Fonarow, GC, Olson, DM, Schwamm, LH, Hannah, D, Lindholm, B, Maisch, L, Lytle, BL, Greiner, MA, Wu, J, Peterson, ED, Pencina, MJ, and Hernandez, AF. "Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care." American Heart Journal 170, no. 1 (July 2015): 36-45.11. Full Text
  - O'Brien, EC, Simon, DN, Roe, MT, Wang, TY, Peterson, ED, and Alexander, KP. "Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)." The American Journal of Cardiology 115, no. 12 (June 2015): 1655-1660. Full Text
  - O'Brien, EC, Kim, S, Hess, PL, Kowey, PR, Fonarow, GC, Piccini, JP, and Peterson, ED. "Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation." Jama Internal Medicine 175, no. 5 (May 2015): 848-850. (Letter) Full Text
  - Mentz, RJ, Greiner, MA, DeVore, AD, Dunlay, SM, Choudhary, G, Ahmad, T, Khazanie, P, Randolph, TC, Griswold, ME, Eapen, ZJ, O'Brien, EC, Thomas, KL, Curtis, LH, and Hernandez, AF. "Ventricular conduction and long-term heart failure outcomes and mortality in African Americans: insights from the Jackson Heart Study." Circulation. Heart Failure 8, no. 2 (March 2015): 243-251. Full Text Open Access Copy
  - Ahmad, T, Wang, T, O'Brien, EC, Samsky, MD, Pura, JA, Lokhnygina, Y, Rogers, JG, Hernandez, AF, Craig, D, Bowles, DE, Milano, CA, Shah, SH, Januzzi, JL, Felker, GM, and Patel, CB. "Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury." Jacc. Heart Failure 3, no. 1 (January 2015): 30-39. Full Text
  - Ahmad, T, Wang, T, O'Brien, EC, Samsky, MD, Pura, JA, Lokhnygina, Y, Rogers, JG, Hernandez, AF, Craig, D, Bowles, DE, Milano, CA, Shah, SH, Januzzi, JL, Felker, M, and Patel, CB. "Effects of Left Ventricular Assist Device Support on Biomarkers of Cardiovascular Stress, Fibrosis, Fluid Homeostasis, Inflammation, and Renal Injury." JACC-HEART FAILURE 3, no. 1 (January 2015): 30-39. Link to Item
  - O'Brien, EC, Simon, DJN, Roe, MT, Wang, TY, Peterson, ED, and Alexander, KP. "Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)." American Journal of Cardiology 115, no. 12 (January 1, 2015): 1655-1660. Full Text
  - Knowles, JW, O'Brien, EC, Greendale, K, Wilemon, K, Genest, J, Sperling, LS, Neal, WA, Rader, DJ, and Khoury, MJ. "Reducing the burden of disease and death from familial hypercholesterolemia: a call to action." American heart journal 168, no. 6 (December 2014): 807-811. Full Text
  - Kuntz, JL, Safford, MM, Singh, JA, Phansalkar, S, Slight, SP, Her, QL, Lapointe, NA, Mathews, R, O'Brien, E, Brinkman, WB, Hommel, K, Farmer, KC, Klinger, E, Maniam, N, Sobko, HJ, Bailey, SC, Cho, I, Rumptz, MH, Vandermeer, ML, and Hornbrook, MC. "Patient-centered interventions to improve medication management and adherence: a qualitative review of research findings." Patient education and counseling 97, no. 3 (December 2014): 310-326. (Review) Full Text
  - O'Brien, EC, Kim, S, Hess, PL, Freeman, JV, Thomas, L, Fonarow, GC, Ansell, JE, Kowey, PR, Hylek, EM, Mahaffey, KW, Chang, P, Piccini, JP, and Peterson, ED. "Impact of the 2014 Atrial Fibrillation Guideline on the Proportion of Patients Recommended for Oral Anticoagulation." Circulation 130 (November 25, 2014). Link to Item
  - O'Brien, EC, Xian, Y, Fonarow, GC, Olson, DM, Schwamm, LH, and Hernandez, AF. "Clinical commentary on "Certain uncertainty: life after stroke from the patient's perspective"." Circulation. Cardiovascular quality and outcomes 7, no. 6 (November 11, 2014): 970-. (Review) Full Text
  - Ahmad, T, Pencina, MJ, Schulte, PJ, O'Brien, E, Whellan, DJ, Piña, IL, Kitzman, DW, Lee, KL, O'Connor, CM, and Felker, GM. "Clinical implications of chronic heart failure phenotypes defined by cluster analysis." Journal of the American College of Cardiology 64, no. 17 (October 21, 2014): 1765-1774. Full Text
  - O'Brien, EC, Simon, DN, Allen, LA, Singer, DE, Fonarow, GC, Kowey, PR, Thomas, LE, Ezekowitz, MD, Mahaffey, KW, Chang, P, Piccini, JP, and Peterson, ED. "Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)." American Heart Journal 168, no. 4 (October 2014): 487-494. Full Text
  - O'Brien, E, Subherwal, S, Roe, MT, Holmes, DN, Thomas, L, Alexander, KP, Wang, TY, and Peterson, ED. "Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?." American Heart Journal 167, no. 5 (May 2014): 762-769. Full Text
  - O'Brien, EC, Holmes, DN, Ansell, JE, Allen, LA, Hylek, E, Kowey, PR, Gersh, BJ, Fonarow, GC, Koller, CR, Ezekowitz, MD, Mahaffey, KW, Chang, P, Peterson, ED, Piccini, JP, and Singer, DE. "Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry." American Heart Journal 167, no. 4 (April 2014): 601-609.e1. Full Text
  - O'Brien, EC, Roe, MT, Fraulo, ES, Peterson, ED, Ballantyne, CM, Genest, J, Gidding, SS, Hammond, E, Hemphill, LC, Hudgins, LC, Kindt, I, Moriarty, PM, Ross, J, Underberg, JA, Watson, K, Pickhardt, D, Rader, DJ, Wilemon, K, and Knowles, JW. "Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry." American Heart Journal 167, no. 3 (March 2014): 342-349.e17. Full Text
  - O'Brien, EC, Roe, MT, Fraulo, ES, Peterson, ED, Ballantyne, CM, Genest, J, Gidding, SS, Hammond, E, Hemphill, LC, Hudgins, LC, Kindt, I, Moriarty, PM, Ross, J, Underberg, JA, Watson, K, Pickhardt, D, Rader, DJ, Wilemon, K, and Knowles, JW. "Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry." American Heart Journal 167, no. 3 (March 1, 2014). Full Text
  - Johnson, AM, Goldstein, LB, Bennett, P, O'Brien, EC, Rosamond, WD, and investigators of the Registry of the North Carolina Stroke Care Collaborative, . "Compliance with acute stroke care quality measures in hospitals with and without primary stroke center certification: the North Carolina Stroke Care Collaborative." Journal of the American Heart Association 3, no. 2 (January 2014): e000423-null. Full Text
  - O'Brien, E, Subherwal, S, Roe, MT, Holmes, DN, Thomas, L, Alexander, KP, Wang, TY, and Peterson, ED. "Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?." American Heart Journal 167, no. 5 (January 1, 2014): 762-769. Full Text
  - O'Brien, EC, Fosbol, EL, Peng, SA, Alexander, KP, Roe, MT, and Peterson, ED. "Association of body mass index and long-term outcomes in older patients with non-ST-segment-elevation myocardial infarction: results from the CRUSADE Registry." Circulation. Cardiovascular Quality and Outcomes 7, no. 1 (January 2014): 102-109. Full Text
  - O'Brien, EC, Holmes, DN, Ansell, JE, Allen, LA, Hylek, E, Kowey, PR, Gersh, BJ, Fonarow, GC, Koller, CR, Ezekowitz, MD, Mahaffey, KW, Chang, P, Peterson, ED, Piccini, JP, and Singer, DE. "Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry." American Heart Journal 167, no. 4 (January 1, 2014). Full Text
  - O'Brien, EC, Roe, MT, Fraulo, ES, Peterson, ED, Ballantyne, CM, Genest, J, Gidding, SS, Hammond, E, Hemphill, LC, Hudgins, LC, Kindt, I, Moriarty, PM, Ross, J, Underberg, JA, Watson, K, Pickhardt, D, Rader, DJ, Wilemon, K, and Knowles, JW. "Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry." American Heart Journal 167, no. 3 (2014): 342-349.e17.
  - O'Brien, EC, Simon, DN, Allen, LA, Singer, DE, Fonarow, GC, Kowey, PR, Thomas, LE, Ezekowitz, MD, Mahaffey, KW, Chang, P, Piccini, JP, and Peterson, ED. "Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)." American Heart Journal 168, no. 4 (January 1, 2014): 487-494. Full Text
  - O'Brien, EC, Rose, KM, Suchindran, CM, Stürmer, T, Chang, PP, Chambless, L, Guild, CS, and Rosamond, WD. "Medication, reperfusion therapy and survival in a community-based setting of hospitalised myocardial infarction." Heart (British Cardiac Society) 99, no. 11 (June 2013): 767-773. Full Text
  - O'Brien, EC, Rose, KM, Suchindran, CM, Sturmer, T, Chang, PP, Alonso, A, Baggett, CD, and Rosamond, WD. "Temporal trends in medical therapies for ST- and non-ST elevation myocardial infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study)." The American journal of cardiology 111, no. 3 (February 2013): 305-311. Full Text
  - Rosamond, W, Johnson, A, Bennett, P, O'Brien, E, Mettam, L, Jones, S, and Coleman, S. "Monitoring and improving acute stroke care: The North Carolina Stroke Care Collaborative." North Carolina medical journal 73, no. 6 (November 2012): 494-498.
  - O'Brien, EC, Rose, KM, Patel, MD, Murphy, CV, and Rosamond, WD. "Clinical outcomes among stroke patients receiving tissue plasminogen activator therapy beyond the 3-hour time window." Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 21, no. 7 (October 2012): 541-546. Full Text
  - Patel, MD, Rose, KM, O'Brien, EC, and Rosamond, WD. "Prehospital notification by emergency medical services reduces delays in stroke evaluation: findings from the North Carolina stroke care collaborative." Stroke 42, no. 8 (August 2011): 2263-2268. Full Text
  - O'Brien, EC, Rose, KM, Shahar, E, and Rosamond, WD. "Stroke Mortality, Clinical Presentation and Day of Arrival: The Atherosclerosis Risk in Communities (ARIC) Study." Stroke Research and Treatment 2011 (January 2011): 383012-null. Full Text
  - Mears, GD, Rosamond, WD, Lohmeier, C, Murphy, C, O'Brien, E, Asimos, AW, and Brice, JH. "A link to improve stroke patient care: a successful linkage between a statewide emergency medical services data system and a stroke registry." Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine 17, no. 12 (December 2010): 1398-1404. Full Text
- Conference Papers
  - Luo, N, Ballew, NG, O’Brien, E, Greiner, M, Peterson, P, Hammill, B, Hardy, NC, Laskey, W, Heidenreich, P, Chang, C-L, Hernandez, A, Curtis, L, Mentz, R, and Fonarow, GC. "EARLY IMPACT OF GUIDELINE PUBLICATION ON ANGIOTENSIN-RECEPTOR NEPRILYSIN INHIBITOR USE AMONG PATIENTS HOSPITALIZED FOR HEART FAILURE." March 2018. Full Text
  - Greene, S, Luo, N, Mentz, RJ, Hardy, C, Laskey, WK, Heidenreich, PA, Yancy, CW, Hernandez, A, Curtis, L, Peterson, PN, Chang, C-L, Turner, S, O'Brien, EC, Fonarow, GC, and Hammill, BG. "Home-Time as a Novel Post-Discharge Outcome for Patients Hospitalized With Heart Failure." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017. Link to Item
  - O'Brien, E, Bloom, D, Koro, C, Lorimer, J, Raman, SR, Mentz, RJ, Hammill, BG, Berdan, LG, Rorick, T, and Janmohamed, S. "Perceptions of the utility and barriers of using electronic health records for patient screening in clinical trials: an in-depth interviews study of site coordinators." May 8, 2017. Link to Item
  - O'Brien, EC, Simon, D, Thomas, L, Singer, D, Kowey, P, Naccarelli, G, Fonarow, G, Reiffel, JA, Ansell, J, Go, AS, Chan, P, Ezekowitz, M, Gersh, B, Allen, L, Freeman, J, Mahaffey, K, Piccini, J, Peterson, E, and Hylek, E. "NUISANCE BLEEDING IN ANTICOAGULATED PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE OUTCOMES REGISTRY FOR BETTER INFORMED TREATMENT OF ATRIAL FIBRILLATION (ORBIT-AF)." March 21, 2017. Link to Item
  - Leonard, T, O'Brien, EC, Gamerman, V, Yow, E, Neely, ML, Conoscenti, CS, and Culver, DA. "Composite Physiologic Index (cpi) Categorization And Gender Age Physiology (gap) Stage Correlation And Differentiation Of Patient-Reported Health-Related Quality Of Life In Patients With Idiopathic Pulmonary Fibrosis (ipf)." 2017. Link to Item
  - Pokorney, S, Platt, R, Ortendahl, L, Woodworth, T, Cocoros, N, Walraven, C, Brown, J, Nair, V, O'Brien, E, Rao, M, Curtis, L, Tenaerts, P, Al-Khalidi, H, and Granger, C. "LOW USE OF ORAL ANTICOAGULATION IN PATIENTS WITH ATRIAL FIBRILLATION AND RISK FOR STROKE IN THE UNITED STATES." April 2016. Full Text
  - Steinberg, B, Shrader, P, Thomas, L, Fonarow, G, Hylek, E, Ansell, J, Kowey, P, Gersh, B, Mahaffey, K, Go, AS, O'Brien, E, Singer, D, Peterson, E, and Piccini, J. "ORAL ANTICOAGULANT SELECTION IN COMMUNITY PATIENTS WITH NEW-ONSET ATRIAL FIBRILLATION: RESULTS FROM THE ORBIT-AF II REGISTRY." April 2016. Full Text
  - Fonarow, GC, Liang, L, Thomas, L, Xian, Y, Saver, JL, Smith, EE, Schwamm, LH, Peterson, E, Hernandez, A, Duncan, PW, O'Brien, E, Bushnell, C, and Prvu Bettger, J. "Assessment of Home Time Following Acute Ischemic Stroke in Medicare Beneficiaries." February 2016. Link to Item
  - O'Brien, EC, Shrader, P, Durheim, MT, Snyder, LD, Todd, JL, Gamerman, V, Anstrom, KJ, Belperio, JA, Culver, DA, De Andrade, JAM, Roman, J, Whelan, TPM, Conoscenti, CS, and Palmer, SM. "Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients." 2016. Link to Item
  - O'Brien, EC, Simon, DN, Thomas, L, Fonarow, GC, Kowey, PR, Mahaffey, KW, Piccini, JP, and Peterson, ED. "Comparative Performance of the R(2)Chads(2), Chads(2), and Cha(2)Ds(2)-vasc Scores in Atrial Fibrillation." Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association (AHA). Orlando, FL. November 7, 2015 - November 11, 2015.: LIPPINCOTT WILLIAMS & WILKINS, November 10, 2015. Link to Item
  - Durheim, M, O'Brien, E, Gamerman, V, Todd, J, Snyder, L, Anstrom, K, Palmer, S, and Conoscenti, C. "Newly Diagnosed IPF at Tertiary Care Pulmonary Centers: Initial Results From the Idiopathic Pulmonary Fibrosis — PROspective Outcomes (IPF-PRO) Registry." October 2015. Full Text
  - O’Brien, EC, DeGoma, E, Moriarty, P, Linton, MF, Shapiro, M, Duell, B, Ballantyne, C, Neal, W, Ahmad, Z, Duffy, D, Hudgins, L, Hemphill, L, Underberg, J, Watson, K, Gidding, S, Baum, S, Dilzell, K, Ross, J, Pickhardt, D, Kindt, I, Rader, D, Wilemon, K, Roe, M, and Knowles, J. "INITIAL RESULTS FROM THE CASCADE-FH REGISTRY: CASCADE SCREENING FOR AWARENESS AND DETECTION OF FAMILIAL HYPERCHOLESTEROLEMIA." March 2015. Full Text
  - Greiner, MA, O'Brien, E, Xian, Y, Bhatt, DL, Maisch, L, Hannah, D, Lindholm, B, Smith, EE, Schwamm, LH, Olson, DM, Peterson, ED, Fonarow, GC, Pencina, MJ, and Hernandez, AF. "High vs. Moderate-intensity Statin Therapy After Ischemic Stroke: Findings from PROSPER." American-Heart-Association/American Stroke Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium. Nashville, TN. February 11, 2015 - February 13, 2015.: LIPPINCOTT WILLIAMS & WILKINS, February 1, 2015. Link to Item
  - O'Brien, EC, Greiner, MA, Xian, Y, Fonarow, GC, Olson, DM, Schwamm, LH, Bhatt, DL, Smith, EE, Maisch, L, Hannah, D, Lindholm, B, Peterson, ED, Pencina, MJ, and Hernandez, AF. "Clinical Effectiveness of Statin Therapy after Ischemic Stroke: Primary Results from the PROSPER Study." American-Heart-Association/American Stroke Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium. Nashville, TN. February 11, 2015 - February 13, 2015.: LIPPINCOTT WILLIAMS & WILKINS, February 1, 2015. Link to Item
  - Xian, Y, Wu, J, O'Brien, EC, Fonarow, GC, Olson, DM, Schwamm, LH, Bhatt, DL, Smith, EE, Hannah, D, Lindholm, B, Maisch, L, Greiner, MA, Lytle, BL, Pencina, MJ, Peterson, ED, and Hernandez, AF. "Clinical Effectiveness of Anticoagulation with Warfarin among Ischemic Stroke Patients with Atrial Fibrillation: Findings from the Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study." American-Heart-Association/American Stroke Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium. Nashville, TN. February 11, 2015 - February 13, 2015.: LIPPINCOTT WILLIAMS & WILKINS, February 1, 2015. Link to Item
  - Mentz, RJ, Greiner, MA, DeVore, AD, Dunlay, SM, Choudhary, G, Khazanie, P, Ahmad, T, Randolph, T, Eapen, ZJ, O'Brien, EC, Thomas, KL, Curtis, LH, and Hernandez, AF. "Ventricular Conduction and Long-term Outcomes in African Americans: Insights from the Jackson Heart Study." November 25, 2014. Link to Item
  - Wang, T, O'Brien, E, Samsky, M, Rogers, J, Hernandez, A, Bowles, D, Felker, GM, Patel, C, and Ahmad, T. "Effects of Left Ventricular Assist Device Support on microRNA Levels." November 25, 2014. Link to Item
  - O'Brien, EC, Holmes, DN, Roe, MT, Peterson, ED, and Alexander, KS. "Treatment and Outcomes by LDL-C Level in Statin-Naive Non-ST-Elevation Myocardial Infarction (NSTEMI) Patients: Findings From the CRUSADE Registry." Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX. November 16, 2013 - November 17, 2013.: LIPPINCOTT WILLIAMS & WILKINS, November 26, 2013. Link to Item
  - O'Brien, EC, Zhao, X, Fonarow, GC, Smith, EE, Schwamm, LH, Bhatt, DL, Xian, Y, Saver, JL, Reeves, MJ, Peterson, ED, and Hernandez, AF. "Readmission for Stroke and Quality of Care Among Patients Hospitalized With Transient Ischemic Attack (TIA): Findings From Get With the Guidelines (GWTG)-Stroke." Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX. November 16, 2013 - November 17, 2013.: LIPPINCOTT WILLIAMS & WILKINS, November 26, 2013. Link to Item
Teaching & Mentoring
Recent Courses
- CRP 247: CLINICAL RESEARCH SEMINAR 2018

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