Emily O'Brien | Scholars@Duke

Emily O'Brien
Assistant Professor in Population Health Sciences

I am an epidemiologist and health services researcher at the Duke Clinical Research Institute. My research focuses on comparative effectiveness, patient-centered outcomes, and pragmatic health services research in cardiovascular and pulmonary disease.

Areas of expertise: Epidemiology, Health Services Research, and Clinical Decision Sciences

Current Appointments & Affiliations

Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2018
Assistant Professor in Neurology, Neurology, Clinical Science Departments 2018
Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2013

Contact Information

2400 Pratt Street, Duke Clin. Research Inst. 6th Floor, Durham, NC 27707
emily.obrien@duke.edu (919) 668-0670

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina at Chapel Hill 2012
Duke Appointment History
- Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2017 - 2018
- Assistant Professor in Medicine, Medicine, Clinical Pharmacology, Medicine 2015 - 2017
- Medical Instructor in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2013 - 2015
- Instructor Temporary in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2013
Recognition
In the News
- NOV 14, 2016 Duke Health News
  
  Nearly A Third of Newly Diagnosed AFib Patients Don't Understand Stroke Risk
Research
Selected Grants
- HEORUSV201208 2019 - 2021
- Using PCORnet to Compare Blood Pressure Control Strategies (Subaward to UCSF) awarded by University of California, San Francisco 2018 - 2020
- Methodology for Linking Clinical and Administrative Databases awarded by Patient Centered Outcomes Research Institute 2014 - 2019
- PROSPER awarded by Patient Centered Outcomes Research Institute 2013 - 2019
- Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage 2019
- Using PCORnet to Compare Blood Pressure Control Strategies (Subaward to UCSF) awarded by University of California, San Francisco 2018 - 2019
- A Collaboration for Improving Outcomes of African Americans with Heart Failure awarded by National Institutes of Health 2013 - 2018
- Extraction Vs Capping Pacing and Defibrillator Leads 2015 - 2016
- PROSPER awarded by Patient Centered Outcomes Research Institute 2013 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kaufman, Brystana G., Emily C. O’Brien, Sally C. Stearns, Roland A. Matsouaka, G Mark Holmes, Morris Weinberger, Lee H. Schwamm, et al. “Medicare Shared Savings ACOs and Hospice Care for Ischemic Stroke Patients..” J Am Geriatr Soc 67, no. 7 (July 2019): 1402–9. https://doi.org/10.1111/jgs.15852.
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  - O’Brien, Emily C., Ana Maria Rodriguez, Hye-Chung Kum, Laura E. Schanberg, Marcy Fitz-Randolph, Sean M. O’Brien, and Soko Setoguchi. “Patient perspectives on the linkage of health data for research: Insights from an online patient community questionnaire..” Int J Med Inform 127 (July 2019): 9–17. https://doi.org/10.1016/j.ijmedinf.2019.04.003.
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  - Thomas, Laine E., Emily C. O’Brien, Jonathan P. Piccini, Ralph B. D’Agostino, and Michael J. Pencina. “Application of net reclassification index to non-nested and point-based risk prediction models: a review..” Eur Heart J 40, no. 23 (June 14, 2019): 1880–87. https://doi.org/10.1093/eurheartj/ehy345.
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  - Foraker, Randi E., Christopher Bush, Melissa A. Greiner, Mario Sims, Kamal Henderson, Sakima Smith, Aurelian Bidulescu, Abigail B. Shoben, N Chantelle Hardy, and Emily O’Brien. “Distribution of Cardiovascular Health by Individual- and Neighborhood-Level Socioeconomic Status: Findings From the Jackson Heart Study..” Glob Heart, June 10, 2019. https://doi.org/10.1016/j.gheart.2019.04.007.
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  - Kaufman, Brystana G., B Steven Spivack, Sally C. Stearns, Paula H. Song, and Emily C. O’Brien. “Impact of Accountable Care Organizations on Utilization, Care, and Outcomes: A Systematic Review..” Med Care Res Rev 76, no. 3 (June 2019): 255–90. https://doi.org/10.1177/1077558717745916.
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  - Pumill, Christopher A., Christopher G. Bush, Melissa A. Greiner, Michael E. Hall, Shannon M. Dunlay, Adolfo Correa, Lesley H. Curtis, et al. “Neck circumference and cardiovascular outcomes: Insights from the Jackson Heart Study..” Am Heart J 212 (June 2019): 72–79. https://doi.org/10.1016/j.ahj.2019.03.001.
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  - Shah, Shreyansh, Ying Xian, DaiWai M. Olson, Gregg C. Fonarow, Eric E. Smith, Lesley Maisch, and Emily C. O’Brien. “Home-time Is a Patient-Centered Outcome Variable for Stroke: An Executive Summary..” J Neurosci Nurs 51, no. 3 (June 2019): 110–12. https://doi.org/10.1097/JNN.0000000000000437.
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  - Snyder, Laurie, Megan L. Neely, Anne S. Hellkamp, Emily O’Brien, Joao de Andrade, Craig S. Conoscenti, Thomas Leonard, et al. “Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry..” Respir Res 20, no. 1 (May 30, 2019). https://doi.org/10.1186/s12931-019-1043-9.
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  - Khan, Sadiya S., Hongyan Ning, Sanjiv J. Shah, Clyde W. Yancy, Mercedes Carnethon, Jarett D. Berry, Robert J. Mentz, et al. “10-Year Risk Equations for Incident Heart Failure in the General Population..” J Am Coll Cardiol 73, no. 19 (May 21, 2019): 2388–97. https://doi.org/10.1016/j.jacc.2019.02.057.
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  - Holmes, DaJuanicia N., Jonathan P. Piccini, Larry A. Allen, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Emily C. O’Brien, et al. “Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score..” Circ Cardiovasc Qual Outcomes 12, no. 5 (May 2019). https://doi.org/10.1161/CIRCOUTCOMES.118.005358.
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  - Luo, Nancy, Steven J. Lippmann, Robert J. Mentz, Melissa A. Greiner, Bradley G. Hammill, N Chantelle Hardy, Warren K. Laskey, et al. “Relationship Between Hospital Characteristics and Early Adoption of Angiotensin-Receptor/Neprilysin Inhibitor Among Eligible Patients Hospitalized for Heart Failure..” J Am Heart Assoc 8, no. 3 (February 5, 2019). https://doi.org/10.1161/JAHA.118.010484.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Laine Thomas, Daniel E. Singer, Gregg C. Fonarow, Kenneth W. Mahaffey, Peter R. Kowey, et al. “Incremental prognostic value of renal function for stroke prediction in atrial fibrillation..” Int J Cardiol 274 (January 1, 2019): 152–57. https://doi.org/10.1016/j.ijcard.2018.07.113.
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  - O’Brien, Emily C., Shuang Li, Laine Thomas, Tracy Y. Wang, Matthew T. Roe, and Eric D. Peterson. “The impact of clinical vs administrative claims coding on hospital risk-adjusted outcomes..” Clin Cardiol 41, no. 9 (September 2018): 1225–31. https://doi.org/10.1002/clc.23059.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Laine E. Thomas, Gregg C. Fonarow, Larry A. Allen, Bernard J. Gersh, Peter R. Kowey, et al. “Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation..” Circulation 138, no. 9 (August 28, 2018): 889–97. https://doi.org/10.1161/CIRCULATIONAHA.117.031354.
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  - Kaufman, Brystana G., David Klemish, Cordt T. Kassner, Jerome P. Reiter, Fan Li, Matthew Harker, Emily C. O’Brien, Donald H. Taylor, and Nrupen A. Bhavsar. “Predicting Length of Hospice Stay: An Application of Quantile Regression..” J Palliat Med 21, no. 8 (August 2018): 1131–36. https://doi.org/10.1089/jpm.2018.0039.
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  - Kelly, Jacob P., Melissa Greiner, Elsayed Z. Soliman, Tiffany C. Randolph, Kevin L. Thomas, Shannon M. Dunlay, Lesley H. Curtis, Emily C. O’Brien, and Robert J. Mentz. “Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study)..” Am J Cardiol 122, no. 2 (July 15, 2018): 340–46. https://doi.org/10.1016/j.amjcard.2018.04.004.
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  - Greene, Stephen J., Emily C. O’Brien, Robert J. Mentz, Nancy Luo, N Chantelle Hardy, Warren K. Laskey, Paul A. Heidenreich, et al. “Home-Time After Discharge Among Patients Hospitalized With Heart Failure..” J Am Coll Cardiol 71, no. 23 (June 12, 2018): 2643–52. https://doi.org/10.1016/j.jacc.2018.03.517.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Jack E. Ansell, Kenneth W. Mahaffey, et al. “Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT-AF..” J Am Heart Assoc 7, no. 12 (June 9, 2018). https://doi.org/10.1161/JAHA.117.006391.
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  - Luo, Nancy, Nicholas G. Ballew, Emily C. O’Brien, Melissa A. Greiner, Pamela N. Peterson, Bradley G. Hammill, N Chantelle Hardy, et al. “Early impact of guideline publication on angiotensin-receptor neprilysin inhibitor use among patients hospitalized for heart failure..” Am Heart J 200 (June 2018): 134–40. https://doi.org/10.1016/j.ahj.2018.01.009.
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  - Mentz, Robert J., Melissa A. Greiner, Paul Muntner, Daichi Shimbo, Mario Sims, Tanya M. Spruill, Benjamin F. Banahan, et al. “Intentional and unintentional medication non-adherence in African Americans: Insights from the Jackson Heart Study..” Am Heart J 200 (June 2018): 51–59. https://doi.org/10.1016/j.ahj.2018.03.007.
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  - Bath, Philip M., Lisa J. Woodhouse, Jason P. Appleton, Maia Beridze, Hanne Christensen, Robert A. Dineen, Lelia Duley, et al. “Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial..” Lancet 391, no. 10123 (March 3, 2018): 850–59. https://doi.org/10.1016/S0140-6736(17)32849-0.
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  - Foraker, Randi E., Avirup Guha, Henry Chang, Emily C. O’Brien, Julie K. Bower, Elliott D. Crouser, Wayne D. Rosamond, and Subha V. Raman. “Survival After MI in a Community Cohort Study: Contribution of Comorbidities in NSTEMI..” Glob Heart 13, no. 1 (March 2018): 13–18. https://doi.org/10.1016/j.gheart.2018.01.002.
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  - Kaufman, Brystana G., Sunghee Kim, Karen Pieper, Larry A. Allen, Bernard J. Gersh, Gerald V. Naccarelli, Michael D. Ezekowitz, et al. “Disease understanding in patients newly diagnosed with atrial fibrillation..” Heart 104, no. 6 (March 2018): 494–501. https://doi.org/10.1136/heartjnl-2017-311800.
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  - Amrock, Stephen M., P Barton Duell, Thomas Knickelbine, Seth S. Martin, Emily C. O’Brien, Karol E. Watson, Joanna Mitri, et al. “Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry..” Atherosclerosis 267 (December 2017): 19–26. https://doi.org/10.1016/j.atherosclerosis.2017.10.006.
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  - Van Houtven, Courtney Harold, Katherine E. M. Miller, Emily C. O’Brien, Jennifer L. Wolff, Jennifer Lindquist, Margaret Kabat, Margaret Campbell-Kotler, Jennifer Henius, and Corrine I. Voils. “Development and Initial Validation of the Caregiver Perceptions About Communication With Clinical Team Members (CAPACITY) Measure..” Med Care Res Rev, December 1, 2017. https://doi.org/10.1177/1077558717747985.
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  - Luo, Nancy, Robert J. Mentz, and Emily C. O’Brien. “Reply: Adoption of Sacubitril/Valsartan Must Take Into Account Different Heart Failure Patient Types..” Jacc Heart Fail 5, no. 9 (September 2017). https://doi.org/10.1016/j.jchf.2017.07.002.
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  - Parikh, Kishan S., Melissa A. Greiner, Wei Wang, Yuan-I Min, Adolfo Correa, Benjamin F. Banahan, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries..” Epidemiology 28, no. 5 (September 2017): 740–46. https://doi.org/10.1097/EDE.0000000000000689.
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  - Tajeu, Gabriel S., John N. Booth, Lisandro D. Colantonio, Rebecca F. Gottesman, George Howard, Daniel T. Lackland, Emily C. O’Brien, et al. “Incident Cardiovascular Disease Among Adults With Blood Pressure <140/90 mm Hg..” Circulation 136, no. 9 (August 29, 2017): 798–812. https://doi.org/10.1161/CIRCULATIONAHA.117.027362.
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  - Steinberg, Benjamin A., Peter Shrader, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, Elaine Hylek, et al. “Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)..” Am Heart J 189 (July 2017): 40–47. https://doi.org/10.1016/j.ahj.2017.03.024.
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  - Anderson, Monique L., Rachel Peragallo Urrutia, Emily C. O’Brien, Nancy M. Allen LaPointe, Alexander J. Christian, Lisa A. Kaltenbach, Laura E. Webb, et al. “Outcomes of a multi-community hypertension implementation study: the American Heart Association's Check. Change. Control. program..” J Clin Hypertens (Greenwich) 19, no. 5 (May 2017): 479–87. https://doi.org/10.1111/jch.12950.
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  - Dunlay, Shannon M., Steven J. Lippmann, Melissa A. Greiner, Emily C. O’Brien, Alanna M. Chamberlain, Robert J. Mentz, and Mario Sims. “Perceived Discrimination and Cardiovascular Outcomes in Older African Americans: Insights From the Jackson Heart Study..” Mayo Clin Proc 92, no. 5 (May 2017): 699–709. https://doi.org/10.1016/j.mayocp.2017.01.024.
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  - Katz, David F., Thomas M. Maddox, Mintu Turakhia, Anil Gehi, Emily C. O’Brien, Steven A. Lubitz, Alexander Turchin, et al. “Contemporary Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Low to Moderate Risk of Stroke After Guideline-Recommended Change in Use of the CHADS2 to the CHA2DS2-VASc Score for Thromboembolic Risk Assessment: Analysis From the National Cardiovascular Data Registry's Outpatient Practice Innovation and Clinical Excellence Atrial Fibrillation Registry..” Circ Cardiovasc Qual Outcomes 10, no. 5 (May 2017). https://doi.org/10.1161/CIRCOUTCOMES.116.003476.
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  - Luo, Nancy, Gregg C. Fonarow, Steven J. Lippmann, Xiaojuan Mi, Paul A. Heidenreich, Clyde W. Yancy, Melissa A. Greiner, et al. “Early Adoption of Sacubitril/Valsartan for Patients With Heart Failure With Reduced Ejection Fraction: Insights From Get With the Guidelines-Heart Failure (GWTG-HF)..” Jacc Heart Fail 5, no. 4 (April 2017): 305–9. https://doi.org/10.1016/j.jchf.2016.12.018.
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  - Xian, Ying, Emily C. O’Brien, Li Liang, Haolin Xu, Lee H. Schwamm, Gregg C. Fonarow, Deepak L. Bhatt, et al. “Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation..” Jama 317, no. 10 (March 14, 2017): 1057–67. https://doi.org/10.1001/jama.2017.1371.
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  - Gehi, Anil K., Emily O’Brien, Rajeev K. Pathak, Prashanthan Sanders, Kevin F. Kennedy, Salim S. Virani, Frederick A. Masoudi, and Thomas M. Maddox. “Implications of the LEGACY trial on US Atrial Fibrillation Patients: An NCDR Research to Practice (R2P) Project..” Am J Cardiol 119, no. 4 (February 15, 2017): 579–84. https://doi.org/10.1016/j.amjcard.2016.10.044.
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  - O’Brien, Emily C., Jingjing Wu, Xin Zhao, Phillip J. Schulte, Gregg C. Fonarow, Adrian F. Hernandez, Lee H. Schwamm, Eric D. Peterson, Deepak L. Bhatt, and Eric E. Smith. “Healthcare Resource Availability, Quality of Care, and Acute Ischemic Stroke Outcomes..” J Am Heart Assoc 6, no. 2 (February 3, 2017). https://doi.org/10.1161/JAHA.116.003813.
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  - Parikh, Kishan S., Melissa A. Greiner, Takeki Suzuki, Adam D. DeVore, Chad Blackshear, Joseph F. Maher, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study..” Jama Cardiol 2, no. 2 (February 1, 2017): 172–80. https://doi.org/10.1001/jamacardio.2016.3234.
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  - Randolph, Tiffany C., Melissa A. Greiner, Chidiebube Egwim, Adrian F. Hernandez, Kevin L. Thomas, Lesley H. Curtis, Paul Muntner, Wei Wang, Robert J. Mentz, and Emily C. O’Brien. “Associations Between Blood Pressure and Outcomes Among Blacks in the Jackson Heart Study..” J Am Heart Assoc 5, no. 12 (December 7, 2016). https://doi.org/10.1161/JAHA.116.003928.
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  - O’Brien, Emily C., Ying Xian, Haolin Xu, Jingjing Wu, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Hospital Variation in Home-Time After Acute Ischemic Stroke: Insights From the PROSPER Study (Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research)..” Stroke 47, no. 10 (October 2016): 2627–33. https://doi.org/10.1161/STROKEAHA.116.013563.
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  - Ahmad, Zahid S., Rolf L. Andersen, Lars H. Andersen, Emily C. O’Brien, Iris Kindt, Peter Shrader, Chandna Vasandani, et al. “US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry..” J Clin Lipidol 10, no. 5 (September 2016): 1223–29. https://doi.org/10.1016/j.jacl.2016.07.011.
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  - Krishnamoorthy, Arun, Melissa A. Greiner, Alain G. Bertoni, Zubin J. Eapen, Emily C. O’Brien, Lesley H. Curtis, Adrian F. Hernandez, and Robert J. Mentz. “The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study..” J Card Fail 22, no. 8 (August 2016): 589–97. https://doi.org/10.1016/j.cardfail.2016.03.004.
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  - Mentz, Robert J., and Emily C. O’Brien. “Can 2 Pills a Day Keep Readmission Away?: Sacubitril/Valsartan to Reduce 30-Day Heart Failure Readmissions..” J Am Coll Cardiol 68, no. 3 (July 19, 2016): 249–51. https://doi.org/10.1016/j.jacc.2016.05.013.
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  - Foraker, Randi E., Melissa Greiner, Mario Sims, Katherine L. Tucker, Amytis Towfighi, Aurelian Bidulescu, Abigail B. Shoben, et al. “Comparison of risk scores for the prediction of stroke in African Americans: Findings from the Jackson Heart Study..” Am Heart J 177 (July 2016): 25–32. https://doi.org/10.1016/j.ahj.2016.04.007.
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  - deGoma, Emil M., Zahid S. Ahmad, Emily C. O’Brien, Iris Kindt, Peter Shrader, Connie B. Newman, Yashashwi Pokharel, et al. “Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry..” Circ Cardiovasc Genet 9, no. 3 (June 2016): 240–49. https://doi.org/10.1161/CIRCGENETICS.116.001381.
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  - O’Brien, Emily C., Sunghee Kim, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Bernard J. Gersh, Jonathan P. Piccini, and Eric D. Peterson. “Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry..” J Am Heart Assoc 5, no. 5 (May 4, 2016). https://doi.org/10.1161/JAHA.115.002721.
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  - Pokorney, Sean D., Emily C. O’Brien, and Christopher B. Granger. “Assessing generalizability of trial results in general practice..” Eur Heart J 37, no. 14 (April 7, 2016): 1154–57. https://doi.org/10.1093/eurheartj/ehv532.
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  - Fonarow, Gregg C., Li Liang, Laine Thomas, Ying Xian, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries..” Stroke 47, no. 3 (March 2016): 836–42. https://doi.org/10.1161/STROKEAHA.115.011599.
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  - Mentz, Robert J., Adrian F. Hernandez, Lisa G. Berdan, Tyrus Rorick, Emily C. O’Brien, Jenny C. Ibarra, Lesley H. Curtis, and Eric D. Peterson. “Good Clinical Practice Guidance and Pragmatic Clinical Trials: Balancing the Best of Both Worlds..” Circulation 133, no. 9 (March 1, 2016): 872–80. https://doi.org/10.1161/CIRCULATIONAHA.115.019902.
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  - O’Brien, Emily C., Jingjing Wu, Phillip J. Schulte, Alexander Christian, Warren Laskey, Deepak L. Bhatt, Eric D. Peterson, Adrian F. Hernandez, and Gregg C. Fonarow. “Statin use, intensity, and 3-year clinical outcomes among older patients with coronary artery disease..” Am Heart J 173 (March 2016): 27–34. https://doi.org/10.1016/j.ahj.2015.11.014.
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  - O’Brien, Emily C., and Laine E. Thomas. “Untangling the paradox: Obesity as prognostic marker in prevalent cardiovascular disease..” Am Heart J 172 (February 2016): 170–72. https://doi.org/10.1016/j.ahj.2015.11.005.
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  - Mentz, Robert J., and Emily C. O’Brien. “Air Pollution in Patients With Heart Failure: Lessons From a Mechanistic Pilot Study of a Filter Intervention..” Jacc Heart Fail 4, no. 1 (January 2016): 65–67. https://doi.org/10.1016/j.jchf.2015.11.008.
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  - O’Brien, Emily C., Michael T. Durheim, Victoria Gamerman, Sandy Garfinkel, Kevin J. Anstrom, Scott M. Palmer, and Craig S. Conoscenti. “Rationale for and design of the Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) registry..” Bmj Open Respir Res 3, no. 1 (2016). https://doi.org/10.1136/bmjresp-2015-000108.
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  - O’Brien, E. C., D. J. N. Simon, L. E. Thomas, E. M. Hylek, B. J. Gersh, J. E. Ansell, P. R. Kowey, et al. “The ORBIT bleeding score: A simple bedside score to assess bleeding risk in atrial fibrillation.” European Heart Journal 36, no. 46 (December 7, 2015): 3258–64. https://doi.org/10.93/eurheartj/ehv476.
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  - O’Brien, Emily C., Melissa A. Greiner, Mario Sims, Natalie Chantelle Hardy, Wei Wang, Eyal Shahar, Adrian F. Hernandez, and Lesley H. Curtis. “Depressive Symptoms and Risk of Cardiovascular Events in Blacks: Findings From the Jackson Heart Study..” Circ Cardiovasc Qual Outcomes 8, no. 6 (November 2015): 552–59. https://doi.org/10.1161/CIRCOUTCOMES.115.001800.
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  - O’Brien, Emily C., Melissa A. Greiner, Ying Xian, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study..” Circulation 132, no. 15 (October 13, 2015): 1404–13. https://doi.org/10.1161/CIRCULATIONAHA.115.016183.
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  - O’Brien, Emily C., Xin Zhao, Gregg C. Fonarow, Phillip J. Schulte, David Dai, Eric E. Smith, Lee H. Schwamm, et al. “Quality of Care and Ischemic Stroke Risk After Hospitalization for Transient Ischemic Attack: Findings From Get With The Guidelines-Stroke..” Circ Cardiovasc Qual Outcomes 8, no. 6 Suppl 3 (October 2015): S117–24. https://doi.org/10.1161/CIRCOUTCOMES.115.002048.
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  - Shah, Bimal R., Emily C. O’Brien, Matthew T. Roe, Anita Y. Chen, and Eric D. Peterson. “The association of in-hospital guideline adherence and longitudinal postdischarge mortality in older patients with non-ST-segment elevation myocardial infarction..” Am Heart J 170, no. 2 (August 2015): 273-280.e1. https://doi.org/10.1016/j.ahj.2015.05.007.
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  - Xian, Ying, Jingjing Wu, Emily C. O’Brien, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) study..” Bmj 351 (July 31, 2015). https://doi.org/10.1136/bmj.h3786.
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  - Ahmad, Tariq, Emily C. O’Brien, Phillip J. Schulte, Susanna R. Stevens, Mona Fiuzat, Dalane W. Kitzman, Kirkwood F. Adams, et al. “Evaluation of the Incremental Prognostic Utility of Increasingly Complex Testing in Chronic Heart Failure..” Circ Heart Fail 8, no. 4 (July 2015): 709–16. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001996.
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  - O’Brien, Emily C., Lisa A. McCoy, Laine Thomas, Eric D. Peterson, and Tracy Y. Wang. “Patient adherence to generic versus brand statin therapy after acute myocardial infarction: Insights from the Can Rapid Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines Registry..” Am Heart J 170, no. 1 (July 2015): 55–61. https://doi.org/10.1016/j.ahj.2015.04.011.
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  - Xian, Ying, Emily C. O’Brien, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deidre Hannah, Brianna Lindholm, et al. “Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care..” Am Heart J 170, no. 1 (July 2015): 36-45.11. https://doi.org/10.1016/j.ahj.2015.04.008.
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  - O’Brien, Emily C., DaJuanicia N. Simon, Matthew T. Roe, Tracy Y. Wang, Eric D. Peterson, and Karen P. Alexander. “Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)..” Am J Cardiol 115, no. 12 (June 15, 2015): 1655–60. https://doi.org/10.1016/j.amjcard.2015.03.007.
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  - O’Brien, Emily C., Sunghee Kim, Paul L. Hess, Peter R. Kowey, Gregg C. Fonarow, Jonathan P. Piccini, and Eric D. Peterson. “Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation..” Jama Intern Med 175, no. 5 (May 2015): 848–50. https://doi.org/10.1001/jamainternmed.2015.13.
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  - Mentz, Robert J., Melissa A. Greiner, Adam D. DeVore, Shannon M. Dunlay, Gaurav Choudhary, Tariq Ahmad, Prateeti Khazanie, et al. “Ventricular conduction and long-term heart failure outcomes and mortality in African Americans: insights from the Jackson Heart Study..” Circ Heart Fail 8, no. 2 (March 2015): 243–51. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001729.
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  - Ahmad, Tariq, Teresa Wang, Emily C. O’Brien, Marc D. Samsky, John A. Pura, Yuliya Lokhnygina, Joseph G. Rogers, et al. “Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury..” Jacc Heart Fail 3, no. 1 (January 2015): 30–39. https://doi.org/10.1016/j.jchf.2014.06.013.
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  - Ahmad, Tariq, Teresa Wang, Emily C. O’Brien, Marc D. Samsky, John A. Pura, Yuliya Lokhnygina, Joseph G. Rogers, et al. “Effects of Left Ventricular Assist Device Support on Biomarkers of Cardiovascular Stress, Fibrosis, Fluid Homeostasis, Inflammation, and Renal Injury.” Jacc Heart Failure 3, no. 1 (January 2015): 30–39.
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  - Knowles, Joshua W., Emily C. O’Brien, Karen Greendale, Katherine Wilemon, Jacques Genest, Laurence S. Sperling, William A. Neal, Daniel J. Rader, and Muin J. Khoury. “Reducing the burden of disease and death from familial hypercholesterolemia: a call to action..” Am Heart J 168, no. 6 (December 2014): 807–11. https://doi.org/10.1016/j.ahj.2014.09.001.
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  - Kuntz, Jennifer L., Monika M. Safford, Jasvinder A. Singh, Shobha Phansalkar, Sarah P. Slight, Qoua Liang Her, Nancy Allen Lapointe, et al. “Patient-centered interventions to improve medication management and adherence: a qualitative review of research findings..” Patient Educ Couns 97, no. 3 (December 2014): 310–26. https://doi.org/10.1016/j.pec.2014.08.021.
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  - O’Brien, Emily C., Sunghee Kim, Paul L. Hess, James V. Freeman, Laine Thomas, Gregg C. Fonarow, Jack E. Ansell, et al. “Impact of the 2014 Atrial Fibrillation Guideline on the Proportion of Patients Recommended for Oral Anticoagulation.” Circulation 130 (November 25, 2014).
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  - O’Brien, Emily C., Ying Xian, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, and Adrian F. Hernandez. “Clinical commentary on "Certain uncertainty: life after stroke from the patient's perspective"..” Circ Cardiovasc Qual Outcomes 7, no. 6 (November 2014). https://doi.org/10.1161/CIRCOUTCOMES.114.001484.
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  - Ahmad, Tariq, Michael J. Pencina, Phillip J. Schulte, Emily O’Brien, David J. Whellan, Ileana L. Piña, Dalane W. Kitzman, Kerry L. Lee, Christopher M. O’Connor, and G Michael Felker. “Clinical implications of chronic heart failure phenotypes defined by cluster analysis..” J Am Coll Cardiol 64, no. 17 (October 28, 2014): 1765–74. https://doi.org/10.1016/j.jacc.2014.07.979.
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  - O’Brien, Emily C., DaJuanicia N. Simon, Larry A. Allen, Daniel E. Singer, Gregg C. Fonarow, Peter R. Kowey, Laine E. Thomas, et al. “Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)..” Am Heart J 168, no. 4 (October 2014): 487–94. https://doi.org/10.1016/j.ahj.2014.07.002.
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  - O’Brien, Emily, Sumeet Subherwal, Matthew T. Roe, DaJuanicia N. Holmes, Laine Thomas, Karen P. Alexander, Tracy Y. Wang, and Eric D. Peterson. “Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?.” Am Heart J 167, no. 5 (May 2014): 762–69. https://doi.org/10.1016/j.ahj.2014.01.009.
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  - Johnson, Anna M., Larry B. Goldstein, Paige Bennett, Emily C. O’Brien, Wayne D. Rosamond, and Wayne D. investigators of the Registry of the North Carolina Stroke Care Collaborative. “Compliance with acute stroke care quality measures in hospitals with and without primary stroke center certification: the North Carolina Stroke Care Collaborative..” J Am Heart Assoc 3, no. 2 (April 10, 2014). https://doi.org/10.1161/JAHA.113.000423.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Jack E. Ansell, Larry A. Allen, Elaine Hylek, Peter R. Kowey, Bernard J. Gersh, et al. “Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry..” Am Heart J 167, no. 4 (April 2014): 601-609.e1. https://doi.org/10.1016/j.ahj.2013.12.014.
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  - O’Brien, Emily C., Matthew T. Roe, Elizabeth S. Fraulo, Eric D. Peterson, Christie M. Ballantyne, Jacques Genest, Samuel S. Gidding, et al. “Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry..” Am Heart J 167, no. 3 (March 2014): 342-349.e17. https://doi.org/10.1016/j.ahj.2013.12.008.
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  - O’Brien, E. C., M. T. Roe, E. S. Fraulo, E. D. Peterson, C. M. Ballantyne, J. Genest, S. S. Gidding, et al. “Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry.” American Heart Journal 167, no. 3 (2014): 342-349.e17.
  - O’Brien, Emily C., Emil L. Fosbol, S Andrew Peng, Karen P. Alexander, Matthew T. Roe, and Eric D. Peterson. “Association of body mass index and long-term outcomes in older patients with non-ST-segment-elevation myocardial infarction: results from the CRUSADE Registry..” Circ Cardiovasc Qual Outcomes 7, no. 1 (January 2014): 102–9. https://doi.org/10.1161/CIRCOUTCOMES.113.000421.
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  - O’Brien, Emily C., Kathryn M. Rose, Chirayath M. Suchindran, Til Stürmer, Patricia P. Chang, Lloyd Chambless, Cameron S. Guild, and Wayne D. Rosamond. “Medication, reperfusion therapy and survival in a community-based setting of hospitalised myocardial infarction..” Heart 99, no. 11 (June 2013): 767–73. https://doi.org/10.1136/heartjnl-2012-303244.
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  - O’Brien, Emily C., Kathryn M. Rose, Chirayath M. Suchindran, Til Sturmer, Patricia P. Chang, Alvaro Alonso, Christopher D. Baggett, and Wayne D. Rosamond. “Temporal trends in medical therapies for ST- and non-ST elevation myocardial infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study)..” Am J Cardiol 111, no. 3 (February 1, 2013): 305–11. https://doi.org/10.1016/j.amjcard.2012.09.032.
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  - Rosamond, Wayne, Anna Johnson, Paige Bennett, Emily O’Brien, Laurie Mettam, Sara Jones, and Sylvia Coleman. “Monitoring and improving acute stroke care: The North Carolina Stroke Care Collaborative..” N C Med J 73, no. 6 (November 2012): 494–98.
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  - O’Brien, Emily C., Kathryn M. Rose, Mehul D. Patel, Carol V. Murphy, and Wayne D. Rosamond. “Clinical outcomes among stroke patients receiving tissue plasminogen activator therapy beyond the 3-hour time window..” J Stroke Cerebrovasc Dis 21, no. 7 (October 2012): 541–46. https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.12.004.
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  - Patel, Mehul D., Kathryn M. Rose, Emily C. O’Brien, and Wayne D. Rosamond. “Prehospital notification by emergency medical services reduces delays in stroke evaluation: findings from the North Carolina stroke care collaborative..” Stroke 42, no. 8 (August 2011): 2263–68. https://doi.org/10.1161/STROKEAHA.110.605857.
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  - O’Brien, Emily C., Kathryn M. Rose, Eyal Shahar, and Wayne D. Rosamond. “Stroke Mortality, Clinical Presentation and Day of Arrival: The Atherosclerosis Risk in Communities (ARIC) Study..” Stroke Res Treat 2011 (2011). https://doi.org/10.4061/2011/383012.
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  - Mears, Greg D., Wayne D. Rosamond, Chad Lohmeier, Carol Murphy, Emily O’Brien, Andrew W. Asimos, and Jane H. Brice. “A link to improve stroke patient care: a successful linkage between a statewide emergency medical services data system and a stroke registry..” Acad Emerg Med 17, no. 12 (December 2010): 1398–1404. https://doi.org/10.1111/j.1553-2712.2010.00925.x.
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  - Wang, Teresa, Emily C. O’Brien, Joseph G. Rogers, Daniel L. Jacoby, Michael E. Chen, Jeffrey M. Testani, Dawn E. Bowles, et al. “Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support..” Asaio J 63, no. 5 (n.d.): 536–41. https://doi.org/10.1097/MAT.0000000000000564.
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- Conference Papers
  - Luo, Nancy, Nicholas G. Ballew, Emily O’Brien, Melissa Greiner, Pamela Peterson, Bradley Hammill, N Chantelle Hardy, et al. “EARLY IMPACT OF GUIDELINE PUBLICATION ON ANGIOTENSIN-RECEPTOR NEPRILYSIN INHIBITOR USE AMONG PATIENTS HOSPITALIZED FOR HEART FAILURE.” In Journal of the American College of Cardiology, 71:A791–A791. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)31332-9.
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  - Greene, Stephen, Nancy Luo, Robert J. Mentz, Chantelle Hardy, Warren K. Laskey, Paul A. Heidenreich, Clyde W. Yancy, et al. “Home-Time as a Novel Post-Discharge Outcome for Patients Hospitalized With Heart Failure.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - O’Brien, Emily, Diane Bloom, Carol Koro, Jamie Lorimer, Sudha R. Raman, Robert J. Mentz, Bradley G. Hammill, Lisa G. Berdan, Ty Rorick, and Salim Janmohamed. “Perceptions of the utility and barriers of using electronic health records for patient screening in clinical trials: an in-depth interviews study of site coordinators.” In Trials, Vol. 18. BIOMED CENTRAL LTD, 2017.
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  - O’Brien, Emily Claire, DaJuanicia Simon, Laine Thomas, Daniel Singer, Peter Kowey, Gerald Naccarelli, Gregg Fonarow, et al. “NUISANCE BLEEDING IN ANTICOAGULATED PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE OUTCOMES REGISTRY FOR BETTER INFORMED TREATMENT OF ATRIAL FIBRILLATION (ORBIT-AF).” In Journal of the American College of Cardiology, 69:536–536. ELSEVIER SCIENCE INC, 2017.
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  - Leonard, T., E. C. O’Brien, V. Gamerman, E. Yow, M. L. Neely, C. S. Conoscenti, and D. A. Culver. “Composite Physiologic Index (cpi) Categorization And Gender Age Physiology (gap) Stage Correlation And Differentiation Of Patient-Reported Health-Related Quality Of Life In Patients With Idiopathic Pulmonary Fibrosis (ipf).” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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  - Pokorney, Sean, Richard Platt, Lisa Ortendahl, Tiffany Woodworth, Noelle Cocoros, Cheryl Walraven, Jeffrey Brown, et al. “LOW USE OF ORAL ANTICOAGULATION IN PATIENTS WITH ATRIAL FIBRILLATION AND RISK FOR STROKE IN THE UNITED STATES.” In Journal of the American College of Cardiology, 67:886–886. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)30887-7.
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  - Steinberg, Benjamin, Peter Shrader, Laine Thomas, Gregg Fonarow, Elaine Hylek, Jack Ansell, Peter Kowey, et al. “ORAL ANTICOAGULANT SELECTION IN COMMUNITY PATIENTS WITH NEW-ONSET ATRIAL FIBRILLATION: RESULTS FROM THE ORBIT-AF II REGISTRY.” In Journal of the American College of Cardiology, 67:885–885. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)30886-5.
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  - Fonarow, Gregg C., Li Liang, Laine Thomas, Ying Xian, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Assessment of Home Time Following Acute Ischemic Stroke in Medicare Beneficiaries.” In Stroke, Vol. 47. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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  - O’Brien, E. C., P. Shrader, M. T. Durheim, L. D. Snyder, J. L. Todd, V. Gamerman, K. J. Anstrom, et al. “Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - O’Brien, Emily C., DaJuanicia N. Simon, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Jonathan P. Piccini, and Eric D. Peterson. “Comparative Performance of the R(2)Chads(2), Chads(2), and Cha(2)Ds(2)-vasc Scores in Atrial Fibrillation.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Durheim, Michael, Emily O’Brien, Victoria Gamerman, Jamie Todd, Laurie Snyder, Kevin Anstrom, Scott Palmer, and Craig Conoscenti. “Newly Diagnosed IPF at Tertiary Care Pulmonary Centers: Initial Results From the Idiopathic Pulmonary Fibrosis — PROspective Outcomes (IPF-PRO) Registry.” In Chest, 148:362A-362A. Elsevier BV, 2015. https://doi.org/10.1378/chest.2268509.
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  - O’Brien, Emily Claire, Emil DeGoma, Patrick Moriarty, MacRae F. Linton, Michael Shapiro, Bart Duell, Christie Ballantyne, et al. “INITIAL RESULTS FROM THE CASCADE-FH REGISTRY: CASCADE SCREENING FOR AWARENESS AND DETECTION OF FAMILIAL HYPERCHOLESTEROLEMIA.” In Journal of the American College of Cardiology, 65:A1372–A1372. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61372-9.
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  - Greiner, Melissa A., Emily O’Brien, Ying Xian, Deepak L. Bhatt, Lesley Maisch, Deidre Hannah, Brianna Lindholm, et al. “High vs. Moderate-intensity Statin Therapy After Ischemic Stroke: Findings from PROSPER.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - O’Brien, Emily C., Melissa A. Greiner, Ying Xian, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Clinical Effectiveness of Statin Therapy after Ischemic Stroke: Primary Results from the PROSPER Study.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Xian, Ying, Jingjing Wu, Emily C. O’Brien, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Clinical Effectiveness of Anticoagulation with Warfarin among Ischemic Stroke Patients with Atrial Fibrillation: Findings from the Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Mentz, Robert J., Melissa A. Greiner, Adam D. DeVore, Shannon M. Dunlay, Gaurav Choudhary, Prateeti Khazanie, Tariq Ahmad, et al. “Ventricular Conduction and Long-term Outcomes in African Americans: Insights from the Jackson Heart Study.” In Circulation, Vol. 130, 2014.
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  - Wang, Teresa, Emily O’Brien, Marc Samsky, Joseph Rogers, Adrian Hernandez, Dawn Bowles, G Michael Felker, Chetan Patel, and Tariq Ahmad. “Effects of Left Ventricular Assist Device Support on microRNA Levels.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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  - O’Brien, Emily C., Dajuanlca N. Holmes, Matthew T. Roe, Eric D. Peterson, and Karen S. Alexander. “Treatment and Outcomes by LDL-C Level in Statin-Naive Non-ST-Elevation Myocardial Infarction (NSTEMI) Patients: Findings From the CRUSADE Registry.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - O’Brien, Emily C., Xin Zhao, Gregg C. Fonarow, Eric E. Smith, Lee H. Schwamm, Deepak L. Bhatt, Ying Xian, et al. “Readmission for Stroke and Quality of Care Among Patients Hospitalized With Transient Ischemic Attack (TIA): Findings From Get With the Guidelines (GWTG)-Stroke.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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Teaching & Mentoring
Recent Courses
- CRP 247: Clinical Research Seminar 2019
- POPHS 701: Applied Analytic Methods for Population Health Sciences I 2019

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