Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 2012
• 

  Previous Appointments & Affiliations

  • Associate Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2020
  • Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2018 - 2020
  • Assistant Professor in Neurology, Neurology, Clinical Science Departments 2020
  • Assistant Professor in Neurology, Neurology, Clinical Science Departments 2018 - 2020
  • Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2017 - 2018
  • Assistant Professor in Medicine, Medicine, Clinical Pharmacology, Medicine 2015 - 2017
  • Medical Instructor in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2013 - 2015
  • Instructor Temporary in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2013
• Recognition
• 

  In the News

  • APR 13, 2020

    Health Care Workers Encouraged to Join COVID-19 Clinical Trial Registry

  • MAY 3, 2018

    Population Health Learning Network

    Minor bleeding not tied to risk of major bleeding in AF patients

  • NOV 16, 2016

    Everyday Health

    Many With Common Atrial Fibrillation Unaware of Stroke Risk

  • NOV 14, 2016

    Duke Health News

    Nearly A Third of Newly Diagnosed AFib Patients Don't Understand Stroke Risk

  • NOV 3, 2016

    Reuters Health

    ED crowding tied to potentially fatal delays in stroke care

  • JUL 13, 2016

    MedWire News

    Sacubitril plus valsartan reduces early readmission risk in HF

  • MAR 1, 2016

    Duke Medicine News

    Q & A with Emily O’Brien: Disparities research “the heart of public health

  • NOV 17, 2015

    Neurology Advisor

    Depression Raises Stroke, Coronary Heart Disease Risk in African Americans

  • MAR 5, 2015

    Medpagetoday

    Stroke Rounds: Nearly A Million New Scripts for Prevention in Afib?

  • MAR 3, 2015

    Medscape

    Recent AF Guidelines Would Significantly Expand OAC Use

  • MAR 2, 2015

    Science Daily

    Guidelines suggest blood thinners for more women, seniors with AFib

  • NOV 13, 2014

    American Heart Association News

    New type of medical research centered on patient values and needs
• Research
• 

  Selected Grants

  • Balancing Risks and Benefits of Direct Oral Anticoagulants in Older Ischemic Stroke Patients with Atrial Fibrillation awarded by National Institutes of Health 2020 - 2025
  • Collaboratory Resource Coordinating Center for Pragmatic and Implementation Studies for the Management of Pain (PRISM) (U24) awarded by National Institutes of Health 2019 - 2024
  • COVID 19_SUA awarded by Pfizer, Inc. 2020 - 2023
  • HERO Program, HERO Registry, HERO-HCQ Trial awarded by Patient Centered Outcomes Research Institute 2020 - 2023
  • Using simulation modeling and real-world data to monitor the effectiveness of the COVID-19 vaccine awarded by Food and Drug Administration 2021 - 2023
  • Evaluating fitness-for-use of Electronic Health Records in Clinical Research awarded by Food and Drug Administration 2019 - 2022
  • NIH Health Care Systems Research Collaboratory - Coordinating Center awarded by National Institutes of Health 2017 - 2022
  • Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage awarded by University of Mississippi Medical Center 2021 - 2022
  • Citizen Science COVID Outcomes awarded by University of California - San Francisco 2020 - 2022
  • Caregivers' Reactions and Experience: Imaging Dementia-Evidence for Amyloid Scanning-CARE IDEAS awarded by Brown University 2017 - 2022
  • In-hospital Use of Sacubitril/Valsartan and Post-discharge Adherence and Clinical Outcomes Following Hospitalization for Heart Failure with Reduced Ejection Fraction awarded by Novartis Pharmaceuticals Corporation 2019 - 2022
  • Using PCORnet to Compare Blood Pressure Control Strategies (Subaward to UCSF) awarded by University of California - San Francisco 2018 - 2022
  • COVID 19_Protocol Development LOI awarded by Pfizer, Inc. 2020 - 2021
  • Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage awarded by University of Mississippi Medical Center 2020 - 2021
  • Hero Ancillary Study: The Nurse HERO Study awarded by Children's Hospital of Philadelphia 2021
  • Early Adoption of Novel Heart Failure Therapy and Patient-Prioritized Outcomes in Clinical Practice: Results from the GWTG-HF Registry awarded by Novartis Pharmaceuticals Corporation 2020
  • Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage awarded by University of Mississippi Medical Center 2019 - 2020
  • Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research awarded by Patient Centered Outcomes Research Institute 2013 - 2020
  • Methodology for Linking Clinical and Administrative Databases awarded by Patient Centered Outcomes Research Institute 2014 - 2019
  • A Collaboration for Improving Outcomes of African Americans with Heart Failure awarded by National Institutes of Health 2013 - 2018
  • Extraction Vs Capping Pacing and Defibrillator Leads awarded by Spectranetics 2015 - 2016
  • Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research awarded by Patient Centered Outcomes Research Institute 2013 - 2016
• 

  External Relationships

  • Boehringer Ingleheim
  • Bristol-Myers Squibb
  • Novartis
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chew, Derek S., Zhen Li, Benjamin A. Steinberg, Emily O’Brien, Jessica Pritchard, T Jared Bunch, Daniel B. Mark, et al. “Association between economic and arrhythmic burden of paroxysmal atrial fibrillation in patients with cardiac implanted electronic devices.” Am Heart J 244 (February 2022): 116–24. https://doi.org/10.1016/j.ahj.2021.11.006.
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    • Carnicelli, Anthony P., Zhen Li, Melissa A. Greiner, Steven J. Lippmann, Stephen J. Greene, Robert J. Mentz, N Chantelle Hardy, et al. “Sacubitril/Valsartan Adherence and Postdischarge Outcomes Among Patients Hospitalized for Heart Failure With Reduced Ejection Fraction.” Jacc. Heart Failure 9, no. 12 (December 2021): 876–86. https://doi.org/10.1016/j.jchf.2021.06.018.
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    • Cooper-DeHoff, Rhonda M., Valy Fontil, Thomas Carton, Alanna M. Chamberlain, Jonathan Todd, Emily C. O’Brien, Kathryn M. Shaw, et al. “Tracking Blood Pressure Control Performance and Process Metrics in 25 US Health Systems: The PCORnet Blood Pressure Control Laboratory.” J Am Heart Assoc 10, no. 21 (November 2, 2021): e022224. https://doi.org/10.1161/JAHA.121.022224.
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    • Richesson, Rachel L., Keith S. Marsolo, Brian J. Douthit, Karen Staman, P Michael Ho, Dana Dailey, Andrew D. Boyd, et al. “Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory.” Journal of the American Medical Informatics Association : Jamia 28, no. 12 (November 2021): 2626–40. https://doi.org/10.1093/jamia/ocab202.
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    • Friedland, Anne, Adrian F. Hernandez, Kevin J. Anstrom, Mei Lin Chen-Lim, Lauren W. Cohen, Judith S. Currier, Christopher B. Forrest, et al. “Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform.” Contemp Clin Trials 109 (October 2021): 106525. https://doi.org/10.1016/j.cct.2021.106525.
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    • Etherton, Mark R., Shreyansh Shah, Xu Haolin, Ying Xian, Lesley Maisch, Deidre Hannah, Brianna Lindholm, et al. “Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors.” Stroke Vasc Neurol 6, no. 3 (September 2021): 384–94. https://doi.org/10.1136/svn-2020-000691.
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    • Greene, Stephen J., Sujung Choi, Steven J. Lippmann, Robert J. Mentz, Melissa A. Greiner, N Chantelle Hardy, Bradley G. Hammill, et al. “Clinical Effectiveness of Sacubitril/Valsartan Among Patients Hospitalized for Heart Failure With Reduced Ejection Fraction.” J Am Heart Assoc 10, no. 16 (August 17, 2021): e021459. https://doi.org/10.1161/JAHA.121.021459.
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    • Carnicelli, Anthony P., Steven J. Lippmann, Stephen J. Greene, Robert J. Mentz, Melissa A. Greiner, N Chantelle Hardy, Bradley G. Hammill, et al. “Sacubitril/Valsartan Initiation and Postdischarge Adherence Among Patients Hospitalized for Heart Failure.” J Card Fail 27, no. 8 (August 2021): 826–36. https://doi.org/10.1016/j.cardfail.2021.03.012.
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    • Wong, Charlene A., William B. Song, Megan Jiao, Emily O’Brien, Peter Ubel, Gary Wang, and Charles D. Scales. “Strategies for research participant engagement: A synthetic review and conceptual framework.” Clin Trials 18, no. 4 (August 2021): 457–65. https://doi.org/10.1177/17407745211011068.
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    • O’Brien, Emily C., Sudha R. Raman, Alicia Ellis, Bradley G. Hammill, Lisa G. Berdan, Tyrus Rorick, Salim Janmohamed, Zachary Lampron, Adrian F. Hernandez, and Lesley H. Curtis. “The use of electronic health records for recruitment in clinical trials: a mixed methods analysis of the Harmony Outcomes Electronic Health Record Ancillary Study.” Trials 22, no. 1 (July 19, 2021): 465. https://doi.org/10.1186/s13063-021-05397-0.
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    • Rao, Vishal N., Christopher G. Bush, Morgana Mongraw-Chaffin, Michael E. Hall, Donald Clark, Marat Fudim, Adolfo Correa, et al. “Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study.” Journal of the American Heart Association 10, no. 14 (July 9, 2021): e020920. https://doi.org/10.1161/jaha.121.020920.
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    • Nelson, Adam J., Neha J. Pagidipati, Vanita R. Aroda, Matthew A. Cavender, Jennifer B. Green, Renato D. Lopes, Hussein Al-Khalidi, et al. “Incorporating SGLT2i and GLP-1RA for Cardiovascular and Kidney Disease Risk Reduction: Call for Action to the Cardiology Community.” Circulation 144, no. 1 (July 6, 2021): 74–84. https://doi.org/10.1161/CIRCULATIONAHA.121.053766.
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    • Forrest, Christopher B., Haolin Xu, Laine E. Thomas, Laura E. Webb, Lauren W. Cohen, Timothy S. Carey, Cynthia H. Chuang, et al. “Impact of the Early Phase of the COVID-19 Pandemic on US Healthcare Workers: Results from the HERO Registry.” J Gen Intern Med 36, no. 5 (May 2021): 1319–26. https://doi.org/10.1007/s11606-020-06529-z.
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    • Steinberg, Benjamin A., Zhen Li, Emily C. O’Brien, Jessica Pritchard, Derek S. Chew, T Jared Bunch, Daniel B. Mark, Yelena Nabutovsky, Melissa A. Greiner, and Jonathan P. Piccini. “Atrial fibrillation burden and heart failure: Data from 39,710 individuals with cardiac implanted electronic devices.” Heart Rhythm 18, no. 5 (May 2021): 709–16. https://doi.org/10.1016/j.hrthm.2021.01.021.
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    • Oshunbade, Adebamike A., Wondwosen Kassahun-Yimer, Karen A. Valle, Arsalan Hamid, Rodney K. Kipchumba, Daisuke Kamimura, Donald Clark, et al. “Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study.” Journal of the American Heart Association 10, no. 7 (April 2021): e017320. https://doi.org/10.1161/jaha.120.017320.
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    • Ferranti, Sarah D. de, Peter Shrader, MacRae F. Linton, Joshua W. Knowles, Lisa C. Hudgins, Irwin Benuck, Iris Kindt, et al. “Children with Heterozygous Familial Hypercholesterolemia in the United States: Data from the Cascade Screening for Awareness and Detection-FH Registry.” J Pediatr 229 (February 2021): 70–77. https://doi.org/10.1016/j.jpeds.2020.09.042.
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    • Nelson, Adam J., Maddalena Ardissino, Kevin Haynes, Sonali Shambhu, Zubin J. Eapen, Darren K. McGuire, Anthony Carnicelli, et al. “Gaps in Evidence-Based Therapy Use in Insured Patients in the United States With Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease.” J Am Heart Assoc 10, no. 2 (January 19, 2021): e016835. https://doi.org/10.1161/JAHA.120.016835.
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    • Curti, Steven A., Joseph A. DeGruy, Christopher Spankovich, Charles E. Bishop, Dan Su, Karen Valle, Emily O’Brien, Yuan-I Min, and John M. Schweinfurth. “Relationship of Overall Cardiovascular Health and Hearing Loss in The Jackson Heart Study Population.” Laryngoscope 130, no. 12 (December 2020): 2879–84. https://doi.org/10.1002/lary.28469.
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    • Butler, M. J., T. M. Spruill, D. A. Johnson, S. Redline, M. Sims, B. C. Jenkins, J. N. Booth, et al. “Suboptimal sleep and incident cardiovascular disease among African Americans in the Jackson Heart Study (JHS).” Sleep Medicine 76 (December 2020): 89–97. https://doi.org/10.1016/j.sleep.2020.09.005.
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    • Mentz, Robert J., Haolin Xu, Emily C. O’Brien, Laine Thomas, Tamas Alexy, Bhanu Gupta, Juan Vilaro, et al. “PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure.” Am Heart J 230 (December 2020): 35–43. https://doi.org/10.1016/j.ahj.2020.09.012.
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    • Ali-Ahmed, Fatima, Karen Pieper, Rebecca North, Larry A. Allen, Paul S. Chan, Michael D. Ezekowitz, Gregg C. Fonarow, et al. “Shared decision-making in atrial fibrillation: patient-reported involvement in treatment decisions.” Eur Heart J Qual Care Clin Outcomes 6, no. 4 (October 1, 2020): 263–72. https://doi.org/10.1093/ehjqcco/qcaa040.
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    • Bachmann, Katherine N., Christianne L. Roumie, Andrew D. Wiese, Carlos G. Grijalva, John B. Buse, Robert Bradford, Emily O. Zalimeni, et al. “Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.” Pharmacol Res Perspect 8, no. 5 (October 2020): e00637. https://doi.org/10.1002/prp2.637.
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    • Van Houtven, Courtney H., Steven J. Lippmann, Emmanuelle Bélanger, Valerie A. Smith, Hailey J. James, Megan Shepherd-Banigan, Eric Jutkowitz, et al. “Measurement Properties of the CAPACITY Instrument to Assess Perceived Communication With the Health Care Team Among Care Partners of Patients With Cognitive Impairment.” Medical Care 58, no. 9 (September 2020): 842–49. https://doi.org/10.1097/mlr.0000000000001363.
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    • Spahillari, Aferdita, Jinyi Zhu, Bart S. Ferket, MG Myriam Hunink, J Jeffrey Carr, James G. Terry, Cheryl Nelson, et al. “Cost-effectiveness of Contemporary Statin Use Guidelines With or Without Coronary Artery Calcium Assessment in African American Individuals.” Jama Cardiol 5, no. 8 (August 1, 2020): 871–80. https://doi.org/10.1001/jamacardio.2020.1240.
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    • Joynt Maddox, Karen E., William K. Bleser, Sandeep R. Das, Nihar R. Desai, Jackie Ng-Osorio, Emily O’Brien, Mitchell A. Psotka, Rishi K. Wadhera, William S. Weintraub, and Madeleine Konig. “Value in Healthcare Initiative: Summary and Key Recommendations.” Circ Cardiovasc Qual Outcomes 13, no. 7 (July 2020): e006612. https://doi.org/10.1161/CIRCOUTCOMES.120.006612.
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    • Bufalino, Vincent J., William K. Bleser, Elizabeth A. Singletary, Bradi B. Granger, Emily C. O’Brien, Mitchell S. V. Elkind, Marianne Hamilton Lopez, et al. “Frontiers of Upstream Stroke Prevention and Reduced Stroke Inequity Through Predicting, Preventing, and Managing Hypertension and Atrial Fibrillation: A Call to Action From the Value in Healthcare Initiative's Predict & Prevent Learning Collaborative.” Circ Cardiovasc Qual Outcomes 13, no. 7 (July 2020): e006780. https://doi.org/10.1161/CIRCOUTCOMES.120.006780.
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    • Oshunbade, Adebamike A., Wondwosen K. Yimer, Karen A. Valle, Donald Clark, Daisuke Kamimura, Wendy B. White, Andrew P. DeFilippis, et al. “Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study.” J Am Heart Assoc 9, no. 12 (June 16, 2020): e014990. https://doi.org/10.1161/JAHA.119.014990.
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    • Glover, LáShauntá M., Loretta R. Cain-Shields, Tanya M. Spruill, Emily C. O’Brien, Sharrelle Barber, Laura Loehr, and Mario Sims. “Goal-Striving Stress and Incident Cardiovascular Disease in Blacks: The Jackson Heart Study.” J Am Heart Assoc 9, no. 9 (May 5, 2020): e015707. https://doi.org/10.1161/JAHA.119.015707.
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    • O’Brien, Emily C., Anne S. Hellkamp, Megan L. Neely, Aparna Swaminathan, Shaun Bender, Laurie D. Snyder, Daniel A. Culver, et al. “Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.” Chest 157, no. 5 (May 2020): 1188–98. https://doi.org/10.1016/j.chest.2019.11.042.
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    • Rockhold, Frank W., Jessica D. Tenenbaum, Rachel Richesson, Keith A. Marsolo, and Emily C. O’Brien. “Design and analytic considerations for using patient-reported health data in pragmatic clinical trials: report from an NIH Collaboratory roundtable.” J Am Med Inform Assoc 27, no. 4 (April 1, 2020): 634–38. https://doi.org/10.1093/jamia/ocz226.
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    • Pletcher, Mark J., Valy Fontil, Thomas Carton, Kathryn M. Shaw, Myra Smith, Sujung Choi, Jonathan Todd, et al. “The PCORnet Blood Pressure Control Laboratory: A Platform for Surveillance and Efficient Trials.” Circ Cardiovasc Qual Outcomes 13, no. 3 (March 2020): e006115. https://doi.org/10.1161/CIRCOUTCOMES.119.006115.
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    • Samsky, Marc D., Li Lin, Stephen J. Greene, Steven J. Lippmann, Pamela N. Peterson, Paul A. Heidenreich, Warren K. Laskey, et al. “Patient Perceptions and Familiarity With Medical Therapy for Heart Failure.” Jama Cardiology 5, no. 3 (March 2020): 292–99. https://doi.org/10.1001/jamacardio.2019.4987.
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    • Kaufman, Brystana G., Emily C. O’Brien, Sally C. Stearns, Roland Matsouaka, G Mark Holmes, Morris Weinberger, Paula H. Song, et al. “The Medicare Shared Savings Program and Outcomes for Ischemic Stroke Patients: a Retrospective Cohort Study.” J Gen Intern Med 34, no. 12 (December 2019): 2740–48. https://doi.org/10.1007/s11606-019-05283-1.
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    • Van Houtven, Courtney Harold, Katherine E. M. Miller, Emily C. O’Brien, Jennifer L. Wolff, Jennifer Lindquist, Margaret Kabat, Margaret Campbell-Kotler, Jennifer Henius, and Corrine I. Voils. “Development and Initial Validation of the Caregiver Perceptions About Communication With Clinical Team Members (CAPACITY) Measure.” Med Care Res Rev 76, no. 6 (December 2019): 784–806. https://doi.org/10.1177/1077558717747985.
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    • Steinberg, Benjamin A., Nicholas G. Ballew, Melissa A. Greiner, Steven J. Lippmann, Lesley H. Curtis, Emily C. O’Brien, Manesh R. Patel, and Jonathan P. Piccini. “Ischemic and Bleeding Outcomes in Patients With Atrial Fibrillation and Contraindications to Oral Anticoagulation.” Jacc Clin Electrophysiol 5, no. 12 (December 2019): 1384–92. https://doi.org/10.1016/j.jacep.2019.07.011.
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    • Gillespie, Shannon L., Cindy M. Anderson, Songzhu Zhao, Yubo Tan, David Kline, Guy Brock, James Odei, et al. “Allostatic load in the association of depressive symptoms with incident coronary heart disease: The Jackson Heart Study.” Psychoneuroendocrinology 109 (November 2019): 104369. https://doi.org/10.1016/j.psyneuen.2019.06.020.
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    • Duell, P Barton, Samuel S. Gidding, Rolf L. Andersen, Thomas Knickelbine, Lars Anderson, Eugenia Gianos, Peter Shrader, et al. “Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry.” Atherosclerosis 289 (October 2019): 85–93. https://doi.org/10.1016/j.atherosclerosis.2019.08.007.
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    • O’Brien, Emily C., and Stephen J. Greene. “Real-World Evidence for Medication Safety: Causal, Confounded, or Capable?” Jacc Heart Fail 7, no. 10 (October 2019): 846–48. https://doi.org/10.1016/j.jchf.2019.05.003.
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    • Xian, Ying, Haolin Xu, Emily C. O’Brien, Shreyansh Shah, Laine Thomas, Michael J. Pencina, Gregg C. Fonarow, et al. “Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.” Jama Neurol 76, no. 10 (October 1, 2019): 1192–1202. https://doi.org/10.1001/jamaneurol.2019.2099.
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    • Foraker, Randi E., Christopher Bush, Melissa A. Greiner, Mario Sims, Kamal Henderson, Sakima Smith, Aurelian Bidulescu, Abigail B. Shoben, N Chantelle Hardy, and Emily O’Brien. “Distribution of Cardiovascular Health by Individual- and Neighborhood-Level Socioeconomic Status: Findings From the Jackson Heart Study.” Glob Heart 14, no. 3 (September 2019): 241–50. https://doi.org/10.1016/j.gheart.2019.04.007.
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    • O’Brien, Eileen C., Ricardo Segurado, Aisling A. Geraghty, Goiuri Alberdi, Ewelina Rogozinska, Arne Astrup, Rubenomar Barakat Carballo, et al. “Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: individual participant data meta-analysis.” Bmj Open 9, no. 8 (August 1, 2019): e025620. https://doi.org/10.1136/bmjopen-2018-025620.
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    • O’Brien, Emily C., Ana Maria Rodriguez, Hye-Chung Kum, Laura E. Schanberg, Marcy Fitz-Randolph, Sean M. O’Brien, and Soko Setoguchi. “Patient perspectives on the linkage of health data for research: Insights from an online patient community questionnaire.” Int J Med Inform 127 (July 2019): 9–17. https://doi.org/10.1016/j.ijmedinf.2019.04.003.
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    • Kaufman, Brystana G., Emily C. O’Brien, Sally C. Stearns, Roland A. Matsouaka, G Mark Holmes, Morris Weinberger, Lee H. Schwamm, et al. “Medicare Shared Savings ACOs and Hospice Care for Ischemic Stroke Patients.” J Am Geriatr Soc 67, no. 7 (July 2019): 1402–9. https://doi.org/10.1111/jgs.15852.
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    • Thomas, Laine E., Emily C. O’Brien, Jonathan P. Piccini, Ralph B. D’Agostino, and Michael J. Pencina. “Application of net reclassification index to non-nested and point-based risk prediction models: a review.” Eur Heart J 40, no. 23 (June 14, 2019): 1880–87. https://doi.org/10.1093/eurheartj/ehy345.
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    • Shah, Shreyansh, Ying Xian, DaiWai M. Olson, Gregg C. Fonarow, Eric E. Smith, Lesley Maisch, and Emily C. O’Brien. “Home-time Is a Patient-Centered Outcome Variable for Stroke: An Executive Summary.” J Neurosci Nurs 51, no. 3 (June 2019): 110–12. https://doi.org/10.1097/JNN.0000000000000437.
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    • Kaufman, Brystana G., B Steven Spivack, Sally C. Stearns, Paula H. Song, and Emily C. O’Brien. “Impact of Accountable Care Organizations on Utilization, Care, and Outcomes: A Systematic Review.” Med Care Res Rev 76, no. 3 (June 2019): 255–90. https://doi.org/10.1177/1077558717745916.
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    • Pumill, Christopher A., Christopher G. Bush, Melissa A. Greiner, Michael E. Hall, Shannon M. Dunlay, Adolfo Correa, Lesley H. Curtis, et al. “Neck circumference and cardiovascular outcomes: Insights from the Jackson Heart Study.” American Heart Journal 212 (June 2019): 72–79. https://doi.org/10.1016/j.ahj.2019.03.001.
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    • Snyder, Laurie, Megan L. Neely, Anne S. Hellkamp, Emily O’Brien, Joao de Andrade, Craig S. Conoscenti, Thomas Leonard, et al. “Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry.” Respir Res 20, no. 1 (May 30, 2019): 105. https://doi.org/10.1186/s12931-019-1043-9.
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    • Khan, Sadiya S., Hongyan Ning, Sanjiv J. Shah, Clyde W. Yancy, Mercedes Carnethon, Jarett D. Berry, Robert J. Mentz, et al. “10-Year Risk Equations for Incident Heart Failure in the General Population.” J Am Coll Cardiol 73, no. 19 (May 21, 2019): 2388–97. https://doi.org/10.1016/j.jacc.2019.02.057.
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    • Holmes, DaJuanicia N., Jonathan P. Piccini, Larry A. Allen, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Emily C. O’Brien, et al. “Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.” Circ Cardiovasc Qual Outcomes 12, no. 5 (May 2019): e005358. https://doi.org/10.1161/CIRCOUTCOMES.118.005358.
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    • Luo, Nancy, Steven J. Lippmann, Robert J. Mentz, Melissa A. Greiner, Bradley G. Hammill, N Chantelle Hardy, Warren K. Laskey, et al. “Relationship Between Hospital Characteristics and Early Adoption of Angiotensin-Receptor/Neprilysin Inhibitor Among Eligible Patients Hospitalized for Heart Failure.” Journal of the American Heart Association 8, no. 3 (February 2019): e010484. https://doi.org/10.1161/jaha.118.010484.
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    • O’Brien, Emily C., DaJuanicia N. Holmes, Laine Thomas, Daniel E. Singer, Gregg C. Fonarow, Kenneth W. Mahaffey, Peter R. Kowey, et al. “Incremental prognostic value of renal function for stroke prediction in atrial fibrillation.” Int J Cardiol 274 (January 1, 2019): 152–57. https://doi.org/10.1016/j.ijcard.2018.07.113.
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    • O’Brien, Emily C., Shuang Li, Laine Thomas, Tracy Y. Wang, Matthew T. Roe, and Eric D. Peterson. “The impact of clinical vs administrative claims coding on hospital risk-adjusted outcomes.” Clin Cardiol 41, no. 9 (September 2018): 1225–31. https://doi.org/10.1002/clc.23059.
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    • O’Brien, Emily C., DaJuanicia N. Holmes, Laine E. Thomas, Gregg C. Fonarow, Larry A. Allen, Bernard J. Gersh, Peter R. Kowey, et al. “Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation.” Circulation 138, no. 9 (August 28, 2018): 889–97. https://doi.org/10.1161/CIRCULATIONAHA.117.031354.
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    • Kaufman, Brystana G., David Klemish, Cordt T. Kassner, Jerome P. Reiter, Fan Li, Matthew Harker, Emily C. O’Brien, Donald H. Taylor, and Nrupen A. Bhavsar. “Predicting Length of Hospice Stay: An Application of Quantile Regression.” J Palliat Med 21, no. 8 (August 2018): 1131–36. https://doi.org/10.1089/jpm.2018.0039.
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    • Kelly, Jacob P., Melissa Greiner, Elsayed Z. Soliman, Tiffany C. Randolph, Kevin L. Thomas, Shannon M. Dunlay, Lesley H. Curtis, Emily C. O’Brien, and Robert J. Mentz. “Relation of Early Repolarization (J Point Elevation) to Mortality in Blacks (from the Jackson Heart Study).” The American Journal of Cardiology 122, no. 2 (July 2018): 340–46. https://doi.org/10.1016/j.amjcard.2018.04.004.
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    • Greene, Stephen J., Emily C. O’Brien, Robert J. Mentz, Nancy Luo, N Chantelle Hardy, Warren K. Laskey, Paul A. Heidenreich, et al. “Home-Time After Discharge Among Patients Hospitalized With Heart Failure.” J Am Coll Cardiol 71, no. 23 (June 12, 2018): 2643–52. https://doi.org/10.1016/j.jacc.2018.03.517.
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    • O’Brien, Emily C., DaJuanicia N. Holmes, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Jack E. Ansell, Kenneth W. Mahaffey, et al. “Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT-AF.” J Am Heart Assoc 7, no. 12 (June 9, 2018). https://doi.org/10.1161/JAHA.117.006391.
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    • Luo, Nancy, Nicholas G. Ballew, Emily C. O’Brien, Melissa A. Greiner, Pamela N. Peterson, Bradley G. Hammill, N Chantelle Hardy, et al. “Early impact of guideline publication on angiotensin-receptor neprilysin inhibitor use among patients hospitalized for heart failure.” American Heart Journal 200 (June 2018): 134–40. https://doi.org/10.1016/j.ahj.2018.01.009.
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    • Mentz, Robert J., Melissa A. Greiner, Paul Muntner, Daichi Shimbo, Mario Sims, Tanya M. Spruill, Benjamin F. Banahan, et al. “Intentional and unintentional medication non-adherence in African Americans: Insights from the Jackson Heart Study.” American Heart Journal 200 (June 2018): 51–59. https://doi.org/10.1016/j.ahj.2018.03.007.
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    • Bath, Philip M., Lisa J. Woodhouse, Jason P. Appleton, Maia Beridze, Hanne Christensen, Robert A. Dineen, Lelia Duley, et al. “Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.” Lancet 391, no. 10123 (March 3, 2018): 850–59. https://doi.org/10.1016/S0140-6736(17)32849-0.
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    • Foraker, Randi E., Avirup Guha, Henry Chang, Emily C. O’Brien, Julie K. Bower, Elliott D. Crouser, Wayne D. Rosamond, and Subha V. Raman. “Survival After MI in a Community Cohort Study: Contribution of Comorbidities in NSTEMI.” Glob Heart 13, no. 1 (March 2018): 13–18. https://doi.org/10.1016/j.gheart.2018.01.002.
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    • Kaufman, Brystana G., Sunghee Kim, Karen Pieper, Larry A. Allen, Bernard J. Gersh, Gerald V. Naccarelli, Michael D. Ezekowitz, et al. “Disease understanding in patients newly diagnosed with atrial fibrillation.” Heart 104, no. 6 (March 2018): 494–501. https://doi.org/10.1136/heartjnl-2017-311800.
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    • Amrock, Stephen M., P Barton Duell, Thomas Knickelbine, Seth S. Martin, Emily C. O’Brien, Karol E. Watson, Joanna Mitri, et al. “Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry.” Atherosclerosis 267 (December 2017): 19–26. https://doi.org/10.1016/j.atherosclerosis.2017.10.006.
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    • Luo, Nancy, Robert J. Mentz, and Emily C. O’Brien. “Reply: Adoption of Sacubitril/Valsartan Must Take Into Account Different Heart Failure Patient Types.” Jacc. Heart Failure 5, no. 9 (September 2017): 689. https://doi.org/10.1016/j.jchf.2017.07.002.
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    • Parikh, Kishan S., Melissa A. Greiner, Wei Wang, Yuan-I Min, Adolfo Correa, Benjamin F. Banahan, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Representativeness of Medicare Participants in the Jackson Heart Study for African American Medicare Beneficiaries.” Epidemiology (Cambridge, Mass.) 28, no. 5 (September 2017): 740–46. https://doi.org/10.1097/ede.0000000000000689.
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    • Tajeu, Gabriel S., John N. Booth, Lisandro D. Colantonio, Rebecca F. Gottesman, George Howard, Daniel T. Lackland, Emily C. O’Brien, et al. “Incident Cardiovascular Disease Among Adults With Blood Pressure <140/90 mm Hg.” Circulation 136, no. 9 (August 29, 2017): 798–812. https://doi.org/10.1161/CIRCULATIONAHA.117.027362.
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    • Steinberg, Benjamin A., Peter Shrader, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, Elaine Hylek, et al. “Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).” Am Heart J 189 (July 2017): 40–47. https://doi.org/10.1016/j.ahj.2017.03.024.
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    • Anderson, Monique L., Rachel Peragallo Urrutia, Emily C. O’Brien, Nancy M. Allen LaPointe, Alexander J. Christian, Lisa A. Kaltenbach, Laura E. Webb, et al. “Outcomes of a multi-community hypertension implementation study: the American Heart Association's Check. Change. Control. program.” J Clin Hypertens (Greenwich) 19, no. 5 (May 2017): 479–87. https://doi.org/10.1111/jch.12950.
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    • Dunlay, Shannon M., Steven J. Lippmann, Melissa A. Greiner, Emily C. O’Brien, Alanna M. Chamberlain, Robert J. Mentz, and Mario Sims. “Perceived Discrimination and Cardiovascular Outcomes in Older African Americans: Insights From the Jackson Heart Study.” Mayo Clin Proc 92, no. 5 (May 2017): 699–709. https://doi.org/10.1016/j.mayocp.2017.01.024.
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    • Katz, David F., Thomas M. Maddox, Mintu Turakhia, Anil Gehi, Emily C. O’Brien, Steven A. Lubitz, Alexander Turchin, et al. “Contemporary Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Low to Moderate Risk of Stroke After Guideline-Recommended Change in Use of the CHADS2 to the CHA2DS2-VASc Score for Thromboembolic Risk Assessment: Analysis From the National Cardiovascular Data Registry's Outpatient Practice Innovation and Clinical Excellence Atrial Fibrillation Registry.” Circ Cardiovasc Qual Outcomes 10, no. 5 (May 2017). https://doi.org/10.1161/CIRCOUTCOMES.116.003476.
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    • Luo, Nancy, Gregg C. Fonarow, Steven J. Lippmann, Xiaojuan Mi, Paul A. Heidenreich, Clyde W. Yancy, Melissa A. Greiner, et al. “Early Adoption of Sacubitril/Valsartan for Patients With Heart Failure With Reduced Ejection Fraction: Insights From Get With the Guidelines-Heart Failure (GWTG-HF).” Jacc. Heart Failure 5, no. 4 (April 2017): 305–9. https://doi.org/10.1016/j.jchf.2016.12.018.
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    • Xian, Ying, Emily C. O’Brien, Li Liang, Haolin Xu, Lee H. Schwamm, Gregg C. Fonarow, Deepak L. Bhatt, et al. “Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation.” Jama 317, no. 10 (March 2017): 1057–67. https://doi.org/10.1001/jama.2017.1371.
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    • Gehi, Anil K., Emily O’Brien, Rajeev K. Pathak, Prashanthan Sanders, Kevin F. Kennedy, Salim S. Virani, Frederick A. Masoudi, and Thomas M. Maddox. “Implications of the LEGACY trial on US Atrial Fibrillation Patients: An NCDR Research to Practice (R2P) Project.” Am J Cardiol 119, no. 4 (February 15, 2017): 579–84. https://doi.org/10.1016/j.amjcard.2016.10.044.
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    • O’Brien, Emily C., Jingjing Wu, Xin Zhao, Phillip J. Schulte, Gregg C. Fonarow, Adrian F. Hernandez, Lee H. Schwamm, Eric D. Peterson, Deepak L. Bhatt, and Eric E. Smith. “Healthcare Resource Availability, Quality of Care, and Acute Ischemic Stroke Outcomes.” Journal of the American Heart Association 6, no. 2 (February 3, 2017). https://doi.org/10.1161/jaha.116.003813.
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    • Parikh, Kishan S., Melissa A. Greiner, Takeki Suzuki, Adam D. DeVore, Chad Blackshear, Joseph F. Maher, Lesley H. Curtis, Adrian F. Hernandez, Emily C. O’Brien, and Robert J. Mentz. “Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart Study.” Jama Cardiology 2, no. 2 (February 2017): 172–80. https://doi.org/10.1001/jamacardio.2016.3234.
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    • Randolph, Tiffany C., Melissa A. Greiner, Chidiebube Egwim, Adrian F. Hernandez, Kevin L. Thomas, Lesley H. Curtis, Paul Muntner, Wei Wang, Robert J. Mentz, and Emily C. O’Brien. “Associations Between Blood Pressure and Outcomes Among Blacks in the Jackson Heart Study.” Journal of the American Heart Association 5, no. 12 (December 7, 2016). https://doi.org/10.1161/jaha.116.003928.
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    • O’Brien, Emily C., Ying Xian, Haolin Xu, Jingjing Wu, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Hospital Variation in Home-Time After Acute Ischemic Stroke: Insights From the PROSPER Study (Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research).” Stroke 47, no. 10 (October 2016): 2627–33. https://doi.org/10.1161/STROKEAHA.116.013563.
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    • Ahmad, Zahid S., Rolf L. Andersen, Lars H. Andersen, Emily C. O’Brien, Iris Kindt, Peter Shrader, Chandna Vasandani, et al. “US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.” Journal of Clinical Lipidology 10, no. 5 (September 2016): 1223–29. https://doi.org/10.1016/j.jacl.2016.07.011.
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    • Krishnamoorthy, Arun, Melissa A. Greiner, Alain G. Bertoni, Zubin J. Eapen, Emily C. O’Brien, Lesley H. Curtis, Adrian F. Hernandez, and Robert J. Mentz. “The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study.” Journal of Cardiac Failure 22, no. 8 (August 2016): 589–97. https://doi.org/10.1016/j.cardfail.2016.03.004.
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    • Foraker, Randi E., Melissa Greiner, Mario Sims, Katherine L. Tucker, Amytis Towfighi, Aurelian Bidulescu, Abigail B. Shoben, et al. “Comparison of risk scores for the prediction of stroke in African Americans: Findings from the Jackson Heart Study.” Am Heart J 177 (July 2016): 25–32. https://doi.org/10.1016/j.ahj.2016.04.007.
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    • Mentz, Robert J., and Emily C. O’Brien. “Can 2 Pills a Day Keep Readmission Away?: Sacubitril/Valsartan to Reduce 30-Day Heart Failure Readmissions.” Journal of the American College of Cardiology 68, no. 3 (July 2016): 249–51. https://doi.org/10.1016/j.jacc.2016.05.013.
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    • deGoma, Emil M., Zahid S. Ahmad, Emily C. O’Brien, Iris Kindt, Peter Shrader, Connie B. Newman, Yashashwi Pokharel, et al. “Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.” Circ Cardiovasc Genet 9, no. 3 (June 2016): 240–49. https://doi.org/10.1161/CIRCGENETICS.116.001381.
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    • O’Brien, Emily C., Sunghee Kim, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Bernard J. Gersh, Jonathan P. Piccini, and Eric D. Peterson. “Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry.” J Am Heart Assoc 5, no. 5 (May 4, 2016). https://doi.org/10.1161/JAHA.115.002721.
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    • Pokorney, Sean D., Emily C. O’Brien, and Christopher B. Granger. “Assessing generalizability of trial results in general practice.” Eur Heart J 37, no. 14 (April 7, 2016): 1154–57. https://doi.org/10.1093/eurheartj/ehv532.
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    • Fonarow, Gregg C., Li Liang, Laine Thomas, Ying Xian, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries.” Stroke 47, no. 3 (March 2016): 836–42. https://doi.org/10.1161/STROKEAHA.115.011599.
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    • O’Brien, Emily C., Jingjing Wu, Phillip J. Schulte, Alexander Christian, Warren Laskey, Deepak L. Bhatt, Eric D. Peterson, Adrian F. Hernandez, and Gregg C. Fonarow. “Statin use, intensity, and 3-year clinical outcomes among older patients with coronary artery disease.” Am Heart J 173 (March 2016): 27–34. https://doi.org/10.1016/j.ahj.2015.11.014.
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    • Mentz, Robert J., Adrian F. Hernandez, Lisa G. Berdan, Tyrus Rorick, Emily C. O’Brien, Jenny C. Ibarra, Lesley H. Curtis, and Eric D. Peterson. “Good Clinical Practice Guidance and Pragmatic Clinical Trials: Balancing the Best of Both Worlds.” Circulation 133, no. 9 (March 1, 2016): 872–80. https://doi.org/10.1161/CIRCULATIONAHA.115.019902.
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    • O’Brien, Emily C., and Laine E. Thomas. “Untangling the paradox: Obesity as prognostic marker in prevalent cardiovascular disease.” Am Heart J 172 (February 2016): 170–72. https://doi.org/10.1016/j.ahj.2015.11.005.
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    • O’Brien, Emily C., Michael T. Durheim, Victoria Gamerman, Sandy Garfinkel, Kevin J. Anstrom, Scott M. Palmer, and Craig S. Conoscenti. “Rationale for and design of the Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) registry.” Bmj Open Respir Res 3, no. 1 (2016): e000108. https://doi.org/10.1136/bmjresp-2015-000108.
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    • Mentz, Robert J., and Emily C. O’Brien. “Air Pollution in Patients With Heart Failure: Lessons From a Mechanistic Pilot Study of a Filter Intervention.” Jacc Heart Fail 4, no. 1 (January 2016): 65–67. https://doi.org/10.1016/j.jchf.2015.11.008.
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    • “The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.” European Heart Journal 36, no. 46 (December 7, 2015): 3258–64. https://doi.org/10.1093/eurheartj/ehv476.
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    • O’Brien, Emily C., DaJuanicia N. Simon, Laine E. Thomas, Elaine M. Hylek, Bernard J. Gersh, Jack E. Ansell, Peter R. Kowey, et al. “The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.” Eur Heart J 36, no. 46 (December 7, 2015): 3258–64. https://doi.org/10.1093/eurheartj/ehv476.
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    • O’Brien, Emily C., Melissa A. Greiner, Mario Sims, Natalie Chantelle Hardy, Wei Wang, Eyal Shahar, Adrian F. Hernandez, and Lesley H. Curtis. “Depressive Symptoms and Risk of Cardiovascular Events in Blacks: Findings From the Jackson Heart Study.” Circ Cardiovasc Qual Outcomes 8, no. 6 (November 2015): 552–59. https://doi.org/10.1161/CIRCOUTCOMES.115.001800.
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    • O’Brien, Emily C., Melissa A. Greiner, Ying Xian, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.” Circulation 132, no. 15 (October 13, 2015): 1404–13. https://doi.org/10.1161/CIRCULATIONAHA.115.016183.
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    • O’Brien, Emily C., Xin Zhao, Gregg C. Fonarow, Phillip J. Schulte, David Dai, Eric E. Smith, Lee H. Schwamm, et al. “Quality of Care and Ischemic Stroke Risk After Hospitalization for Transient Ischemic Attack: Findings From Get With The Guidelines-Stroke.” Circ Cardiovasc Qual Outcomes 8, no. 6 Suppl 3 (October 2015): S117–24. https://doi.org/10.1161/CIRCOUTCOMES.115.002048.
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    • Shah, Bimal R., Emily C. O’Brien, Matthew T. Roe, Anita Y. Chen, and Eric D. Peterson. “The association of in-hospital guideline adherence and longitudinal postdischarge mortality in older patients with non-ST-segment elevation myocardial infarction.” Am Heart J 170, no. 2 (August 2015): 273-280.e1. https://doi.org/10.1016/j.ahj.2015.05.007.
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    • Xian, Ying, Jingjing Wu, Emily C. O’Brien, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) study.” Bmj 351 (July 31, 2015): h3786. https://doi.org/10.1136/bmj.h3786.
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    • O’Brien, Emily C., Lisa A. McCoy, Laine Thomas, Eric D. Peterson, and Tracy Y. Wang. “Patient adherence to generic versus brand statin therapy after acute myocardial infarction: Insights from the Can Rapid Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines Registry.” Am Heart J 170, no. 1 (July 2015): 55–61. https://doi.org/10.1016/j.ahj.2015.04.011.
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    • Xian, Ying, Emily C. O’Brien, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deidre Hannah, Brianna Lindholm, et al. “Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care.” Am Heart J 170, no. 1 (July 2015): 36-45.11. https://doi.org/10.1016/j.ahj.2015.04.008.
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    • Ahmad, Tariq, Emily C. O’Brien, Phillip J. Schulte, Susanna R. Stevens, Mona Fiuzat, Dalane W. Kitzman, Kirkwood F. Adams, et al. “Evaluation of the Incremental Prognostic Utility of Increasingly Complex Testing in Chronic Heart Failure.” Circ Heart Fail 8, no. 4 (July 2015): 709–16. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001996.
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    • O’Brien, Emily C., DaJuanicia N. Simon, Matthew T. Roe, Tracy Y. Wang, Eric D. Peterson, and Karen P. Alexander. “Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry).” Am J Cardiol 115, no. 12 (June 15, 2015): 1655–60. https://doi.org/10.1016/j.amjcard.2015.03.007.
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    • O’Brien, Emily C., Sunghee Kim, Paul L. Hess, Peter R. Kowey, Gregg C. Fonarow, Jonathan P. Piccini, and Eric D. Peterson. “Effect of the 2014 atrial fibrillation guideline revisions on the proportion of patients recommended for oral anticoagulation.” Jama Intern Med 175, no. 5 (May 2015): 848–50. https://doi.org/10.1001/jamainternmed.2015.13.
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    • Mentz, Robert J., Melissa A. Greiner, Adam D. DeVore, Shannon M. Dunlay, Gaurav Choudhary, Tariq Ahmad, Prateeti Khazanie, et al. “Ventricular conduction and long-term heart failure outcomes and mortality in African Americans: insights from the Jackson Heart Study.” Circulation. Heart Failure 8, no. 2 (March 2015): 243–51. https://doi.org/10.1161/circheartfailure.114.001729.
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    • Ahmad, Tariq, Teresa Wang, Emily C. O’Brien, Marc D. Samsky, John A. Pura, Yuliya Lokhnygina, Joseph G. Rogers, et al. “Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury.” Jacc Heart Fail 3, no. 1 (January 2015): 30–39. https://doi.org/10.1016/j.jchf.2014.06.013.
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    • Knowles, Joshua W., Emily C. O’Brien, Karen Greendale, Katherine Wilemon, Jacques Genest, Laurence S. Sperling, William A. Neal, Daniel J. Rader, and Muin J. Khoury. “Reducing the burden of disease and death from familial hypercholesterolemia: a call to action.” Am Heart J 168, no. 6 (December 2014): 807–11. https://doi.org/10.1016/j.ahj.2014.09.001.
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    • Kuntz, Jennifer L., Monika M. Safford, Jasvinder A. Singh, Shobha Phansalkar, Sarah P. Slight, Qoua Liang Her, Nancy Allen Lapointe, et al. “Patient-centered interventions to improve medication management and adherence: a qualitative review of research findings.” Patient Education and Counseling 97, no. 3 (December 2014): 310–26. https://doi.org/10.1016/j.pec.2014.08.021.
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    • O’Brien, Emily C., Sunghee Kim, Paul L. Hess, James V. Freeman, Laine Thomas, Gregg C. Fonarow, Jack E. Ansell, et al. “Impact of the 2014 Atrial Fibrillation Guideline on the Proportion of Patients Recommended for Oral Anticoagulation.” Circulation 130 (November 25, 2014).
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    • O’Brien, Emily C., Ying Xian, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, and Adrian F. Hernandez. “Clinical commentary on "Certain uncertainty: life after stroke from the patient's perspective".” Circ Cardiovasc Qual Outcomes 7, no. 6 (November 2014): 970. https://doi.org/10.1161/CIRCOUTCOMES.114.001484.
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    • Ahmad, Tariq, Michael J. Pencina, Phillip J. Schulte, Emily O’Brien, David J. Whellan, Ileana L. Piña, Dalane W. Kitzman, Kerry L. Lee, Christopher M. O’Connor, and G Michael Felker. “Clinical implications of chronic heart failure phenotypes defined by cluster analysis.” J Am Coll Cardiol 64, no. 17 (October 28, 2014): 1765–74. https://doi.org/10.1016/j.jacc.2014.07.979.
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    • O’Brien, Emily C., DaJuanicia N. Simon, Larry A. Allen, Daniel E. Singer, Gregg C. Fonarow, Peter R. Kowey, Laine E. Thomas, et al. “Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).” Am Heart J 168, no. 4 (October 2014): 487–94. https://doi.org/10.1016/j.ahj.2014.07.002.
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    • O’Brien, Emily, Sumeet Subherwal, Matthew T. Roe, DaJuanicia N. Holmes, Laine Thomas, Karen P. Alexander, Tracy Y. Wang, and Eric D. Peterson. “Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?” Am Heart J 167, no. 5 (May 2014): 762–69. https://doi.org/10.1016/j.ahj.2014.01.009.
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    • Johnson, Anna M., Larry B. Goldstein, Paige Bennett, Emily C. O’Brien, Wayne D. Rosamond, and Wayne D. investigators of the Registry of the North Carolina Stroke Care Collaborative. “Compliance with acute stroke care quality measures in hospitals with and without primary stroke center certification: the North Carolina Stroke Care Collaborative.” J Am Heart Assoc 3, no. 2 (April 10, 2014): e000423. https://doi.org/10.1161/JAHA.113.000423.
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    • O’Brien, Emily C., DaJuanicia N. Holmes, Jack E. Ansell, Larry A. Allen, Elaine Hylek, Peter R. Kowey, Bernard J. Gersh, et al. “Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.” Am Heart J 167, no. 4 (April 2014): 601-609.e1. https://doi.org/10.1016/j.ahj.2013.12.014.
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    • O’Brien, Emily C., Matthew T. Roe, Elizabeth S. Fraulo, Eric D. Peterson, Christie M. Ballantyne, Jacques Genest, Samuel S. Gidding, et al. “Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry.” Am Heart J 167, no. 3 (March 2014): 342-349.e17. https://doi.org/10.1016/j.ahj.2013.12.008.
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    • O’Brien, E. C., M. T. Roe, E. S. Fraulo, E. D. Peterson, C. M. Ballantyne, J. Genest, S. S. Gidding, et al. “Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry.” American Heart Journal 167, no. 3 (2014): 342-349.e17.
    • O’Brien, Emily C., Emil L. Fosbol, S Andrew Peng, Karen P. Alexander, Matthew T. Roe, and Eric D. Peterson. “Association of body mass index and long-term outcomes in older patients with non-ST-segment-elevation myocardial infarction: results from the CRUSADE Registry.” Circ Cardiovasc Qual Outcomes 7, no. 1 (January 2014): 102–9. https://doi.org/10.1161/CIRCOUTCOMES.113.000421.
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    • O’Brien, Emily C., Kathryn M. Rose, Chirayath M. Suchindran, Til Stürmer, Patricia P. Chang, Lloyd Chambless, Cameron S. Guild, and Wayne D. Rosamond. “Medication, reperfusion therapy and survival in a community-based setting of hospitalised myocardial infarction.” Heart 99, no. 11 (June 2013): 767–73. https://doi.org/10.1136/heartjnl-2012-303244.
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    • O’Brien, Emily C., Kathryn M. Rose, Chirayath M. Suchindran, Til Sturmer, Patricia P. Chang, Alvaro Alonso, Christopher D. Baggett, and Wayne D. Rosamond. “Temporal trends in medical therapies for ST- and non-ST elevation myocardial infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study).” Am J Cardiol 111, no. 3 (February 1, 2013): 305–11. https://doi.org/10.1016/j.amjcard.2012.09.032.
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    • Rosamond, Wayne, Anna Johnson, Paige Bennett, Emily O’Brien, Laurie Mettam, Sara Jones, and Sylvia Coleman. “Monitoring and improving acute stroke care: The North Carolina Stroke Care Collaborative.” N C Med J 73, no. 6 (November 2012): 494–98.
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    • O’Brien, Emily C., Kathryn M. Rose, Mehul D. Patel, Carol V. Murphy, and Wayne D. Rosamond. “Clinical outcomes among stroke patients receiving tissue plasminogen activator therapy beyond the 3-hour time window.” J Stroke Cerebrovasc Dis 21, no. 7 (October 2012): 541–46. https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.12.004.
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    • Patel, Mehul D., Kathryn M. Rose, Emily C. O’Brien, and Wayne D. Rosamond. “Prehospital notification by emergency medical services reduces delays in stroke evaluation: findings from the North Carolina stroke care collaborative.” Stroke 42, no. 8 (August 2011): 2263–68. https://doi.org/10.1161/STROKEAHA.110.605857.
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    • O’Brien, Emily C., Kathryn M. Rose, Eyal Shahar, and Wayne D. Rosamond. “Stroke Mortality, Clinical Presentation and Day of Arrival: The Atherosclerosis Risk in Communities (ARIC) Study.” Stroke Res Treat 2011 (2011): 383012. https://doi.org/10.4061/2011/383012.
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    • Mears, Greg D., Wayne D. Rosamond, Chad Lohmeier, Carol Murphy, Emily O’Brien, Andrew W. Asimos, and Jane H. Brice. “A link to improve stroke patient care: a successful linkage between a statewide emergency medical services data system and a stroke registry.” Acad Emerg Med 17, no. 12 (December 2010): 1398–1404. https://doi.org/10.1111/j.1553-2712.2010.00925.x.
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    • Wang, Teresa, Emily C. O’Brien, Joseph G. Rogers, Daniel L. Jacoby, Michael E. Chen, Jeffrey M. Testani, Dawn E. Bowles, et al. “Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support.” Asaio J 63, no. 5 (n.d.): 536–41. https://doi.org/10.1097/MAT.0000000000000564.
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  • Conference Papers

    • Carnicelli, Anthony P., Stephen Greene, Steven Lippmann, Robert J. Mentz, Melissa Greiner, Chantelle Hardy, Bradley G. Hammill, et al. “Sacubitril/valsartan Initiation and Adherence Patterns Following Hospitalization for Heart Failure.” In Journal of Cardiac Failure, 26:S91–S91, 2020.
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    • Cooper-DeHoff, Rhonda M., Valy Fontil, Thomas Carton, Kathryn McAuliffe, Myra Smith, Sujung Choi, Jonathon Todd, et al. “Blood Pressure Control in the Real World - Early Evidence From a National Blood Pressure Surveillance System.” In Circulation, Vol. 141, 2020. https://doi.org/10.1161/circ.141.suppl_1.56Circulation.
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    • Palmer, S. M., M. L. Neely, J. A. Belperio, S. Bender, D. A. Culver, J. De Andrade, E. C. O’Brien, et al. “Improving Our Understanding of Progressive Fibrosing Interstitial Lung Diseases (ILDs): Design of the ILD-PRO Registry.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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    • Swaminathan, Aparna, Emily O’Brien, Anne Hellkamp, Megan Neely, Shaun Bender, Laurie Snyder, Daniel Culver, et al. “HEALTH-RELATED QUALITY OF LIFE MEASURES IN IDIOPATHIC PULMONARY FIBROSIS: DATA FROM THE IPF-PRO REGISTRY.” In Chest, 156:A180–81. Elsevier BV, 2019. https://doi.org/10.1016/j.chest.2019.08.248.
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    • Sharma, Abhinav, Adrian F. Hernandez, Peter Shrader, Gail D. Wygant, Manuela DiFusco, and Emily C. O’Brien. “Eliminate Thromboembolism: Improving Anticoagulation in Non-Valvular Atrial Fibrillation Patients' (ELITE) Registry Insights From the Final Results.” In Circulation, Vol. 138, 2018.
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    • Luo, Nancy, Nicholas G. Ballew, Emily O’Brien, Melissa Greiner, Pamela Peterson, Bradley Hammill, N Chantelle Hardy, et al. “EARLY IMPACT OF GUIDELINE PUBLICATION ON ANGIOTENSIN-RECEPTOR NEPRILYSIN INHIBITOR USE AMONG PATIENTS HOSPITALIZED FOR HEART FAILURE.” In Journal of the American College of Cardiology, 71:A791–A791. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)31332-9.
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    • Shah, Shreyansh, Haolin Xu, Ying Xian, Lesley Maisch, Deidre Hannah, Brianna Lindholm, Barbara L. Lytie, et al. “Patterns of Discharge Antidepressant Therapy Use After Acute Ischemic Stroke: Insights From the Prosper Study.” In Stroke, Vol. 49. LIPPINCOTT WILLIAMS & WILKINS, 2018.
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    • Greene, Stephen, Nancy Luo, Robert J. Mentz, Chantelle Hardy, Warren K. Laskey, Paul A. Heidenreich, Clyde W. Yancy, et al. “Home-Time as a Novel Post-Discharge Outcome for Patients Hospitalized With Heart Failure.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Sharma, Abhinav, Adrian F. Hernandez, Pearl Zakroysky, Melissa Hamilton, and Emily C. O’Brien. “Eliminate Thromboembolism: Improving Anticoagulation in Non-Valvular Atrial Fibrillation Patients' (ELITE) Registry - Insights From the Baseline Results.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • O’Brien, Emily, Diane Bloom, Carol Koro, Jamie Lorimer, Sudha R. Raman, Robert J. Mentz, Bradley G. Hammill, Lisa G. Berdan, Ty Rorick, and Salim Janmohamed. “Perceptions of the utility and barriers of using electronic health records for patient screening in clinical trials: an in-depth interviews study of site coordinators.” In Trials, Vol. 18. BIOMED CENTRAL LTD, 2017.
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    • O’Brien, Emily Claire, DaJuanicia Simon, Laine Thomas, Daniel Singer, Peter Kowey, Gerald Naccarelli, Gregg Fonarow, et al. “NUISANCE BLEEDING IN ANTICOAGULATED PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE OUTCOMES REGISTRY FOR BETTER INFORMED TREATMENT OF ATRIAL FIBRILLATION (ORBIT-AF).” In Journal of the American College of Cardiology, 69:536–536. Elsevier BV, 2017. https://doi.org/10.1016/s0735-1097(17)33925-6.
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    • Leonard, T., E. C. O’Brien, V. Gamerman, E. Yow, M. L. Neely, C. S. Conoscenti, and D. A. Culver. “Composite Physiologic Index (cpi) Categorization And Gender Age Physiology (gap) Stage Correlation And Differentiation Of Patient-Reported Health-Related Quality Of Life In Patients With Idiopathic Pulmonary Fibrosis (ipf).” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • Pokorney, Sean, Richard Platt, Lisa Ortendahl, Tiffany Woodworth, Noelle Cocoros, Cheryl Walraven, Jeffrey Brown, et al. “LOW USE OF ORAL ANTICOAGULATION IN PATIENTS WITH ATRIAL FIBRILLATION AND RISK FOR STROKE IN THE UNITED STATES.” In Journal of the American College of Cardiology, 67:886–886. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)30887-7.
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    • Steinberg, Benjamin, Peter Shrader, Laine Thomas, Gregg Fonarow, Elaine Hylek, Jack Ansell, Peter Kowey, et al. “ORAL ANTICOAGULANT SELECTION IN COMMUNITY PATIENTS WITH NEW-ONSET ATRIAL FIBRILLATION: RESULTS FROM THE ORBIT-AF II REGISTRY.” In Journal of the American College of Cardiology, 67:885–885. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)30886-5.
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    • Fonarow, Gregg C., Li Liang, Laine Thomas, Ying Xian, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Assessment of Home Time Following Acute Ischemic Stroke in Medicare Beneficiaries.” In Stroke, Vol. 47. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • O’Brien, E. C., P. Shrader, M. T. Durheim, L. D. Snyder, J. L. Todd, V. Gamerman, K. J. Anstrom, et al. “Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • O’Brien, Emily C., DaJuanicia N. Simon, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Jonathan P. Piccini, and Eric D. Peterson. “Comparative Performance of the R(2)Chads(2), Chads(2), and Cha(2)Ds(2)-vasc Scores in Atrial Fibrillation.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Randolph, Tiffany C., Melissa A. Greiner, Chidiebube Egwim, Adrian F. Hernandez, Kevin L. Thomas, Lesley H. Curtis, Paul Muntner, Wei Wang, Robert J. Mentz, and Emily C. O’Brien. “The Association Between Blood Pressure Control and Outcomes Among Black Participants in the Jackson Heart Study.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Durheim, Michael, Emily O’Brien, Victoria Gamerman, Jamie Todd, Laurie Snyder, Kevin Anstrom, Scott Palmer, and Craig Conoscenti. “Newly Diagnosed IPF at Tertiary Care Pulmonary Centers: Initial Results From the Idiopathic Pulmonary Fibrosis — PROspective Outcomes (IPF-PRO) Registry.” In Chest, 148:362A-362A. Elsevier BV, 2015. https://doi.org/10.1378/chest.2268509.
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    • O’Brien, Emily Claire, Emil DeGoma, Patrick Moriarty, MacRae F. Linton, Michael Shapiro, Bart Duell, Christie Ballantyne, et al. “INITIAL RESULTS FROM THE CASCADE-FH REGISTRY: CASCADE SCREENING FOR AWARENESS AND DETECTION OF FAMILIAL HYPERCHOLESTEROLEMIA.” In Journal of the American College of Cardiology, 65:A1372–A1372. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61372-9.
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    • Greiner, Melissa A., Emily O’Brien, Ying Xian, Deepak L. Bhatt, Lesley Maisch, Deidre Hannah, Brianna Lindholm, et al. “High vs. Moderate-intensity Statin Therapy After Ischemic Stroke: Findings from PROSPER.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • O’Brien, Emily C., Jingjing Wu, Phillip J. Schulte, Gregg C. Fonarow, Adrian F. Hernandez, Lee H. Schwamm, Eric D. Peterson, Deepak L. Bhatt, and Eric E. Smith. “Healthcare Resource Availability, Acute Ischemic Stroke Outcomes and Quality of Care.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • O’Brien, Emily C., Melissa A. Greiner, Eyal Shahar, N Chantelle Hardy, Mario Sims, Wei Wang, Adrian F. Hernandez, and Lesley H. Curtis. “Depressive Symptoms and Risk of Stroke in African Americans: Findings from the Jackson Heart Study.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • O’Brien, Emily C., Melissa A. Greiner, Ying Xian, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Clinical Effectiveness of Statin Therapy after Ischemic Stroke: Primary Results from the PROSPER Study.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Xian, Ying, Jingjing Wu, Emily C. O’Brien, Gregg C. Fonarow, DaiWai M. Olson, Lee H. Schwamm, Deepak L. Bhatt, et al. “Clinical Effectiveness of Anticoagulation with Warfarin among Ischemic Stroke Patients with Atrial Fibrillation: Findings from the Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.” In Stroke, Vol. 46. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Mentz, Robert J., Melissa A. Greiner, Adam D. DeVore, Shannon M. Dunlay, Gaurav Choudhary, Prateeti Khazanie, Tariq Ahmad, et al. “Ventricular Conduction and Long-term Outcomes in African Americans: Insights from the Jackson Heart Study.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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    • O’Brien, Emily C., Jingjing Wu, Phillip Schulte, Alexander Christian, Deepak L. Bhatt, Warren K. Laskey, Adrian F. Hernandez, and Gregg C. Fonarow. “High versus Low-to-Moderate Intensity Statin Treatment and One -Year Clinical Outcomes Among Older Patients With Coronary Artery Disease.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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    • Wang, Teresa, Emily O’Brien, Marc Samsky, Joseph Rogers, Adrian Hernandez, Dawn Bowles, G Michael Felker, Chetan Patel, and Tariq Ahmad. “Effects of Left Ventricular Assist Device Support on microRNA Levels.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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    • O’Brien, Emily C., Dajuanlca N. Holmes, Matthew T. Roe, Eric D. Peterson, and Karen S. Alexander. “Treatment and Outcomes by LDL-C Level in Statin-Naive Non-ST-Elevation Myocardial Infarction (NSTEMI) Patients: Findings From the CRUSADE Registry.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • O’Brien, Emily C., Xin Zhao, Gregg C. Fonarow, Eric E. Smith, Lee H. Schwamm, Deepak L. Bhatt, Ying Xian, et al. “Readmission for Stroke and Quality of Care Among Patients Hospitalized With Transient Ischemic Attack (TIA): Findings From Get With the Guidelines (GWTG)-Stroke.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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• Teaching & Mentoring
• 

  Recent Courses

  • POPHS 920: Analytic Methods I: Study Design, Data, and Descriptive Analysis 2021
  • CRP 247: Clinical Research Seminar 2020
  • POPHS 701: Applied Analytic Methods for Population Health Sciences I 2020

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