Erich Senin Huang

Journal article J Clin Oncol · October 1, 2006 Featured Publication PURPOSE: This study aims to explore gene expression profiles that are associated with locoregional (LR) recurrence in breast cancer after mastectomy. PATIENTS AND METHODS: A total of 94 breast cancer patients who underwent mastectomy between 1990 and 2001 ... Full text Link to item Cite

Bayesian analysis of binary prediction tree models for retrospectively sampled outcomes.

Journal article Biostatistics · October 2004 Featured Publication Classification tree models are flexible analysis tools which have the ability to evaluate interactions among predictors as well as generate predictions for responses of interest. We describe Bayesian analysis of a specific class of tree models in which bin ... Full text Link to item Cite

An overview of genomic data analysis.

Journal article Surgery · September 2004 Featured Publication Full text Link to item Cite

Towards integrated clinico-genomic models for personalized medicine: combining gene expression signatures and clinical factors in breast cancer outcomes prediction.

Journal article Hum Mol Genet · October 15, 2003 Featured Publication Genomic data, particularly genome-scale measures of gene expression derived from DNA microarray studies, has the potential for adding enormous information to the analysis of biological phenotypes. Perhaps the most successful application of this data has be ... Full text Link to item Cite

Distinct gene expression phenotypes of cells lacking Rb and Rb family members.

Journal article Cancer Res · July 1, 2003 Featured Publication The study of tumor suppressor gene function has been aided by the creation of discrete gene alterations in the mouse. One such example can be seen in the study of tumor suppressor gene function in general and the retinoblastoma (Rb) tumor suppressor in par ... Link to item Cite

Gene expression phenotypic models that predict the activity of oncogenic pathways.

Journal article Nat Genet · June 2003 Featured Publication High-density DNA microarrays measure expression of large numbers of genes in one assay. The ability to find underlying structure in complex gene expression data sets and rigorously test association of that structure with biological conditions is essential ... Full text Link to item Cite

Gene expression predictors of breast cancer outcomes.

Journal article Lancet · May 10, 2003 Featured Publication BACKGROUND: Correlation of risk factors with genomic data promises to provide specific treatment for individual patients, and needs interpretation of complex, multivariate patterns in gene expression data, as well as assessment of their ability to improve ... Full text Link to item Cite

Gene expression profiling for prediction of clinical characteristics of breast cancer.

Journal article Recent Prog Horm Res · 2003 Featured Publication We have applied techniques of gene expression analysis to the analysis of human breast cancer by identifying metagene models with the capacity to discriminate breast tumors based on estrogen receptor (ER) status as well as the propensity for lymph node met ... Full text Link to item Cite

Predicting the clinical status of human breast cancer by using gene expression profiles.

Journal article Proc Natl Acad Sci U S A · September 25, 2001 Featured Publication Prognostic and predictive factors are indispensable tools in the treatment of patients with neoplastic disease. For the most part, such factors rely on a few specific cell surface, histological, or gross pathologic features. Gene expression assays have the ... Full text Link to item Cite

Myc requires distinct E2F activities to induce S phase and apoptosis.

Journal article Mol Cell · July 2001 Featured Publication Previous work has shown that the Myc transcription factor induces transcription of the E2F1, E2F2, and E2F3 genes. Using primary mouse embryo fibroblasts deleted for individual E2F genes, we now show that Myc-induced S phase and apoptosis requires distinct ... Full text Link to item Cite

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis.

Journal article Mol Cell Biol · July 2001 Featured Publication We have used high-density DNA microarrays to provide an analysis of gene regulation during the mammalian cell cycle and the role of E2F in this process. Cell cycle analysis was facilitated by a combined examination of gene control in serum-stimulated fibro ... Full text Link to item Cite