Erin Smith

Journal article J Clin Invest · April 1, 2026 The gastrointestinal tract varies in structure and function by region, yet the drivers of region-specific inflammatory disease remain elusive. Here, a TNF-overexpressing murine model (TnfΔARE/+) of Crohn's disease (CD) was used to investigate how pathobion ... Full text Link to item Cite

Chlamydia trachomatis: a model for intracellular bacterial parasitism.

Journal article J Bacteriol · March 20, 2025 Chlamydia comprises a diverse group of obligate intracellular bacteria that cause infections in animals, including humans. These organisms share fascinating biology, including distinct developmental stages, non-canonical cell surface structures, and adapta ... Full text Link to item Cite

A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication.

Journal article The EMBO journal · October 2021 Remodeling of host cellular membrane transport pathways is a common pathogenic trait of many intracellular microbes that is essential to their intravacuolar life cycle and proliferation. The bacterium Brucella abortus generates a host endoplasmic reticulum ... Full text Cite

Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle.

Journal article mBio · March 2020 Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is known, how they i ... Full text Cite