Erin V Shea

Journal article Curr Treat Options Oncol · December 24, 2025 Improved survival in pediatric oncology has highlighted the growing burden of cancer treatment-related cardiotoxicity among survivors of childhood cancers. While the cardiotoxicity of anthracyclines and chest radiation are well documented as major contribu ... Full text Link to item Cite

Insulin Resistance after Fontan Palliation.

Journal article Pediatr Cardiol · December 2025 Patients with a single ventricle heart who had Fontan palliation (S/P Fontan) are at increased risk for acquired morbidity. Insulin resistance (IR) is a predictor of cardiac morbidity and mortality. A single-center, cross-sectional study using S/P Fontan a ... Full text Link to item Cite

Pediatric heart transplant in donation after circulatory death using normothermic regional perfusion.

Journal article J Thorac Cardiovasc Surg · October 2025 OBJECTIVE: Orthotopic heart transplant is the definitive option for pediatric patients with end-stage heart failure. Unfortunately, the greatest contributor to waitlist mortality has been a shortage of available hearts for transplant. Donation after circul ... Full text Link to item Cite

Partial Heart Transplant for Congenital Heart Disease.

Journal article JAMA · September 23, 2025 IMPORTANCE: Partial heart transplant, or living valve replacement, has the potential to advance surgical management of irreparable valvular disease by providing a viable option with capacity for growth. OBJECTIVES: To describe the early experience and asse ... Full text Open Access Link to item Cite

Consensus recommendations and considerations for the delivery and monitoring of gene therapy in patients with Duchenne muscular dystrophy.

Journal article Neuromuscul Disord · September 2025 Gene transfer therapy represents a major advancement in the treatment of patients with Duchenne muscular dystrophy (DMD). As clinical use expands, there is an urgent need for standardized, evidence and practice-informed guidelines to ensure safe and equita ... Full text Link to item Cite

Research Gaps in Pediatric Heart Failure: Defining the Gaps and Then Closing Them Over the Next Decade.

Journal article J Card Fail · January 2024 Given the numerous opportunities and the wide knowledge gaps in pediatric heart failure, an international group of pediatric heart failure experts with diverse backgrounds were invited and tasked with identifying research gaps in each pediatric heart failu ... Full text Link to item Cite

Pediatric Heart Transplant Rejection After COVID-19 Infection.

Journal article Transplant Proc · October 2023 BACKGROUND: Infections have been associated with rejection episodes in solid organ transplant recipients. We report an association between COVID-19 infection and heart transplant (HT) rejection. CASE DESCRIPTION: The patient was 14 years old and 6.5 years ... Full text Link to item Cite

Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

Journal article Drug Metab Dispos · January 2013 Studies in microsomal and reconstituted systems have shown that the presence of one cytochrome P450 isoform can significantly influence the catalytic activity of another isoform. In this study, we assessed whether CYP2E1 could influence the catalytic activ ... Full text Link to item Cite

Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions.

Journal article Biochemistry · May 17, 2011 Cytochrome P450 (CYP or P450)-mediated drug metabolism requires the interaction of P450s with their redox partner, cytochrome P450 reductase (CPR). In this work, we have investigated the role of P450 hydrophobic residues in complex formation with CPR and u ... Full text Link to item Cite