Scholars@Duke
Esen Karamursel Akpek

Esen Karamursel Akpek

Stephen and Frances Foster Distinguished Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery

Scholarly Works

Matching-adjusted indirect comparison of acoltremon ophthalmic solution 0.003% and cyclosporine 0.05% ophthalmic emulsion for increased tear production in patients with dry eye disease.

Journal article J Comp Eff Res · June 2026 Aim: Dry eye disease (DED) is a chronic, multifactorial condition arising through loss of tear film and ocular surface homeostasis. Treatment aims to restore natural tear production and normalize ocular surface homeostasis. Several prescription medications ... Full text Link to item Cite

Atopic dermatitis and ocular surface disorders: a United States claims-based cross-sectional study.

Journal article BMC Ophthalmol · April 2, 2026 BACKGROUND: To estimate the prevalence of ocular surface disorders (OSDs) by atopic dermatitis (AD) status and evaluate healthcare resource utilization (HRU) among patients with AD. METHODS: Patients (all ages) enrolled in the Optum Clinformatics® database ... Full text Link to item Cite

Outcomes Evaluated in Randomized Controlled Trials of Treatments for Dry Eye: A Systematic Review.

Journal article Cornea · March 1, 2026 PURPOSE: To initiate the process of core outcome set development for dry eye disease (DED) by conducting a systematic review of all outcomes in randomized controlled trials (RCTs) of treatments for DED. A core outcome set is an agreed-upon minimum set of o ... Full text Link to item Cite

Impact of Corneal Punctate Epithelial Staining on Patient Satisfaction After Cataract Surgery: An Area of Unmet Need for Clinical Guidance.

Journal article Cornea · January 13, 2026 PURPOSE: The goal of this study is to review the existing evidence to quantify the impact of corneal punctate epithelial erosions (PEE) on postoperative refractive error-related patient dissatisfaction after cataract surgery. METHODS: PubMed and the Cochra ... Full text Link to item Cite

Patient-Reported Symptoms Versus Clinician-Measured Signs to Distinguish Sjogren's in Patients With Dry Eye.

Journal article Transl Vis Sci Technol · January 5, 2026 PURPOSE: The purpose of this study was to evaluate clinical factors that could differentiate patients with Sjogren's disease-related dry eye (SDDE) from non-SDDE. METHODS: Patients with SDDE (n = 20), non-SDDE (n = 47), and healthy control participants (n ... Full text Link to item Cite

Delphi panel on neuromodulation as a treatment strategy for dry eye disease: Unlocking the potential of natural tear production.

Journal article Ocul Surf · January 2026 PURPOSE: Chronic tear deficiency, through reduced production and/or increased evaporation, is regarded as a root cause of dry eye disease (DED). The goal of treating DED is restoration of the tear film ultimately resulting in ocular surface homeostasis. Mu ... Full text Link to item Cite

Corneal complications of Sjögren's disease: Insights from a large tertiary ophthalmological care center.

Journal article Ocul Surf · January 2026 PURPOSE: To report the demographic characteristics, clinical spectrum, and outcomes of patients with extra-glandular corneal manifestations of Sjögren's disease (SjD). DESIGN: Retrospective review of electronic medical records. PARTICIPANTS: Consecutive pa ... Full text Link to item Cite

Prevalence of novel Sjögren's antibodies in a multi-center cohort of dry eye patients.

Journal article Ocul Surf · January 2026 PURPOSE: To assess the prevalence of novel Sjögren's disease (SjD) autoantibodies in dry eye disease (DED) patients with or without SjD. PARTICIPANTS: DED patients were recruited from two tertiary care clinics and categorized by SjD status per the 2016 Ame ... Full text Link to item Cite

Corneal Staining Responder Analysis: A Clinically Meaningful Dry Eye Outcome.

Journal article Ophthalmology · December 2025 PURPOSE: Thus far, clinical studies related to dry eye disease (DED) have focused on demonstrating a statistically significant difference in various ocular surface and tear film parameters and patient symptoms between the test arm versus comparator. Howeve ... Full text Link to item Cite

TFOS DEWS III.

Journal article Am J Ophthalmol · November 21, 2025 , (DED).,, , . (MGD) , , ,,.,,. ,T, ()., ., .(,).. TFOS DEWS III , , . ... Full text Link to item Cite

TFOS DEWS III: Management and Therapy.

Journal article Am J Ophthalmol · November 2025 This report provides an evidence-based review of current strategies to manage dry eye disease (DED). First-line management focuses on methods to replenish, conserve, and stimulate the tear film, with an emphasis on ocular supplements, which remain the corn ... Full text Link to item Cite

Surgical Considerations for the Human Implantation of the Gore Synthetic Corneal Device.

Journal article Cornea · November 1, 2025 PURPOSE: To describe the surgical technique for implantation of a novel flexible, suturable, intrastromal synthetic cornea device. METHODS: This report is a description of a novel surgical technique. Adult patients (≥18 years) with corneal edema who met sp ... Full text Link to item Cite

Feature developments in artificial corneal devices: a review.

Journal article Br J Ophthalmol · August 20, 2025 Corneal disease ranks as the fifth leading cause of global blindness, affecting more than 10 million individuals. Donor corneal transplantation, keratoplasty, remains the mainstay of addressing loss of corneal clarity. Historically, full-thickness penetrat ... Full text Link to item Cite

Ophthalmologic involvement in Sjogren's disease

Book section · July 24, 2025 Sjögren's disease, an autoimmune condition commonly characterized by dry eye and dry mouth, remains significantly underappreciated, underdiagnosed, and undertreated. Given the complex nature of the disease, clinical course, and vast array of symptoms, unde ... Full text Cite

Conjunctivitis in Adults with Atopic Dermatitis Treated with Dupilumab: An Observational Study of Clinical Characteristics, Symptomatology, and Treatment.

Journal article Adv Ther · July 2025 INTRODUCTION: Conjunctivitis is more prevalent in patients with atopic dermatitis (AD) than the general population, and is the most common adverse event during dupilumab treatment for AD. We aimed to characterize conjunctivitis diagnosed during AD dupiluma ... Full text Link to item Cite

2023 International Rome consensus for the nomenclature of Sjögren disease.

Journal article Nat Rev Rheumatol · July 2025 Nomenclature for the disease widely known as Sjögren syndrome has proven unsatisfactory. Patients have perceived 'syndrome' as indicative of a vague collection of symptoms, prompting the Sjögren's Foundation to abandon the term. Furthermore, the traditiona ... Full text Link to item Cite

Artificial Intelligence Aided Analysis of Anterior Segment Optical Coherence Tomography Imaging to Monitor the Device-Cornea Joint After Synthetic Cornea Implantation.

Journal article Transl Vis Sci Technol · June 2, 2025 PURPOSE: The purpose of this study was to assess the utility of artificial intelligence (AI) assisted analysis of anterior segment optical coherence tomography (AS-OCT) imaging of the device-cornea joint in predicting outcomes of an intrastromal synthetic ... Full text Link to item Cite

Severe Corneal Ulceration After Cosmetic Keratopigmentation.

Journal article Cornea · May 20, 2025 PURPOSE: Keratopigmentation is a well-described procedure often used to address corneal opacities. Purely cosmetic keratopigmentation, in the absence of underlying corneal pathology has increased in popularity recently, with the intention of changing eye c ... Full text Link to item Cite

Pooled results from two pivotal randomized controlled clinical trials: ESSENCE-1 and ESSENCE-2 to assess efficacy and safety of a water-free ciclosporin 0.1% formulation for the treatment of dry eye disease.

Journal article Graefes Arch Clin Exp Ophthalmol · April 2025 PURPOSE: This pooled analysis of two pivotal studies (ESSENCE-1 and ESSENCE-2) evaluated treatment effects of a water-free ciclosporin 0.1% solution in dry eye disease (DED) patients in the overall population and in subgroups according to sex, age, and bas ... Full text Link to item Cite

Enhancing online cataract surgery patient education materials through artificial intelligence.

Journal article Can J Ophthalmol · April 2025 OBJECTIVE: To assess the feasibility of using artificial intelligence (AI) to improve readability of online cataract surgery patient education materials (PEMs) in English and Spanish. PARTICIPANTS: Websites with information dedicated to educating patients ... Full text Link to item Cite

Reply.

Journal article Ophthalmology · February 2025 Full text Link to item Cite

Identifying the greatest surgeon-perceived barriers and challenges in performing corneal transplantation in India.

Journal article Int Ophthalmol · January 20, 2025 OBJECTIVE: There is currently no systematic method of assessing limitations in performing corneal transplantation. The purpose of the study was to identify the limitations of performing corneal transplantation in India. DESIGN: Cross-sectional survey study ... Full text Link to item Cite

Dry Eye Diagnosis Is an Independent Risk Factor for Developing Depression and Anxiety Among Elderly

Journal article Cornea · January 1, 2025 Purpose:To evaluate whether dry eye disease (DED) diagnosis may increase the subsequent risk of developing depression and anxiety.Methods:In this retrospective cohort study, Medicare beneficiaries aged 65 and older with a new diagnosis of DED, no prior his ... Full text Cite

Prognostic Significance of Biointegration at the Optic-Cornea Joint in Keratoprosthesis Implantation.

Journal article Cornea · December 3, 2024 PURPOSE: The purpose of this study was to characterize the morphological and immunological aspects of biointegration at the optic-cornea joint of a second-generation synthetic corneal device. METHODS: The initial prototype, single-piece optic-skirt configu ... Full text Link to item Cite

Reply.

Journal article Ophthalmology · December 2024 Full text Link to item Cite

Demographic and Psychiatric Associations With Dry Eye in a Medicare Population.

Journal article Cornea · December 1, 2024 PURPOSE: The purpose of this study was to investigate the impact of demographic characteristics and psychiatric comorbidity on the prevalence of dry eye disease in the American geriatric population. METHODS: Data were collected from a 2011 nationwide sampl ... Full text Link to item Cite

Development and Validation of Claims-Based Algorithms for Conjunctivitis and Keratitis.

Journal article Pharmacoepidemiol Drug Saf · November 2024 BACKGROUND: Ocular surface disorders have been reported among patients with various medical conditions, including atopic dermatitis (AD). Nonetheless, validated algorithms to identify conjunctivitis and keratitis in claims data are lacking. OBJECTIVE: Deve ... Full text Link to item Cite

The evolution of cyclosporine treatments for treatment of ocular surface diseases.

Journal article Curr Opin Allergy Clin Immunol · October 1, 2024 PURPOSE OF REVIEW: Cyclosporine is a versatile immunomodulatory drug commonly employed in modern medicine. Although cyclosporine was initially used to prevent solid organ transplant rejection, its indications have extended to treat many inflammatory or aut ... Full text Link to item Cite

Dexamethasone Intracanalicular Insert for Clinically Significant Aqueous-Deficient Dry Eye: A Randomized Controlled Trial.

Journal article Ophthalmology · September 2024 PURPOSE: To evaluate a commercially available dexamethasone intracanalicular insert to treat dry eye. DESIGN: Single-center, double-masked randomized controlled trial. PARTICIPANTS: Patients with clinically significant aqueous-deficient dry eye (combined o ... Full text Link to item Cite

Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study.

Journal article Lancet · August 10, 2024 BACKGROUND: Sjögren's disease is a chronic autoimmune disease with an unmet need for targeted therapies. The aim of the TWINSS study is to evaluate the safety and efficacy of iscalimab, a monoclonal antibody against CD40, in patients with active Sjögren's ... Full text Link to item Cite

Cornea Classic: Bron, Evans, and Smith, "Grading of Corneal and Conjunctival Staining in the Context of Other Dry Eye Tests" (2003).

Journal article Cornea · August 1, 2024 Dry eye is an increasingly common ocular condition with significant impact on quality of life due to eye discomfort and blurred vision complaints. In addition, the financial burden of dry eye on both patients and society is substantial. Although there has ... Full text Link to item Cite

Ten-Year Outcome of Boston Type I Keratoprosthesis Surgery at a Tertiary Care Center.

Journal article Cornea · August 1, 2024 PURPOSE: The aim of this study was to report long-term outcomes of patients who have undergone Boston type I keratoprosthesis (KPro) surgery. METHODS: This study was a retrospective review. Inclusion criteria were KPro surgery between 2006 and 2012 and at ... Full text Link to item Cite

Efficacy of a new water-free topical cyclosporine 0.1% solution for optimizing the ocular surface in patients with dry eye and cataract.

Journal article J Cataract Refract Surg · June 1, 2024 This is a pooled analysis from 2 phase III clinical trials investigating a water-free topical cyclosporine 0.1% for the treatment of moderate to severe dry eye. The analyses included 1162 patients: 35% with cataract, 20% with pseudophakia, and 45% without ... Full text Link to item Cite

Design and Biocompatibility of a Novel, Flexible Artificial Cornea.

Journal article Transl Vis Sci Technol · May 1, 2024 PURPOSE: We sought to introduce the materials, design, and biocompatibility of a flexible and suturable artificial corneal device. METHODS: Single-piece, fully synthetic, optic-skirt design devices were made from compact perfluoroalkoxy alkane. The skirt a ... Full text Link to item Cite

Usability of Patient Education-Oriented Cataract Surgery Websites.

Journal article Ophthalmology · April 2024 PURPOSE: To assess the web accessibility and readability of patient-oriented educational websites for cataract surgery. DESIGN: Cross-sectional electronic survey. PARTICIPANTS: Websites with information dedicated to educating patients about cataract surger ... Full text Link to item Cite

The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation.

Conference Semin Arthritis Rheum · April 2024 Sjögren's disease (SjD) is a systemic autoimmune exocrinopathy with key features of dryness, pain, and fatigue. SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developi ... Full text Link to item Cite

United States Regulatory Approval of Topical Treatments for Dry Eye.

Journal article Am J Ophthalmol · February 2024 PURPOSE: To report the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration (FDA) for approval of topical dry eye treatments. DESIGN: Comparative analysis of clinical trials' methods. METHODS: We reviewed the onl ... Full text Link to item Cite

Utilizing visual symptoms to distinguish dry eye from glaucoma, cataract, and suspect glaucoma patients: a cross-sectional study.

Journal article BMC Ophthalmol · January 9, 2024 BACKGROUND: The diagnosis of dry eye and other common ophthalmological conditions can be supported using patient reported symptoms, which is increasingly useful in contexts such as telemedicine. We aim to ascertain visual symptoms that differentiate dry ey ... Full text Link to item Cite

Sjögren's Versus Non-Sjögren's Ocular Features: Similar Symptoms, But Significantly Worse Signs.

Journal article Invest Ophthalmol Vis Sci · January 2, 2024 PURPOSE: To examine the ocular signs and symptoms in participants of the Sjögren's International Collaborative Clinical Alliance cohort, and to compare them across Sjögren's disease (SjD) status. METHODS: Our study population comprised 3380 Sjögren's Inter ... Full text Link to item Cite

WHAT ARE THE INDICATIONS AND CONTRAINDICATIONS FOR THE USE OF PERIOCULAR CORTICOSTEROID INJECTIONS?

Book section · January 1, 2024 Periocular corticosteroid injection is an effective technique for treating inflammatory ocular disorders without inducing systemic side effects. This mode of delivery is generally indicated in patients who have failed hourly topical steroids, those with un ... Full text Cite

Long-term outcomes of therapeutic corneal transplants performed in a tertiary eye care hospital in South India.

Journal article Indian J Ophthalmol · September 2023 PURPOSE: This study aimed to review the demographics, clinical characteristics, and long-term outcomes of therapeutic penetrating keratoplasty (TPK) performed in a tertiary eye care hospital. METHODS: Case records of 149 therapeutic transplants (135 patien ... Full text Link to item Cite

Twelve-Month Clinical and Histopathological Performance of a Novel Synthetic Cornea Device in Rabbit Model.

Journal article Transl Vis Sci Technol · August 1, 2023 PURPOSE: To report the biological stability and postoperative outcomes of a second-generation, single-piece, flexible synthetic cornea in a rabbit model. METHODS: Device materials and design were amended to enhance biointegration. Optic skirt design device ... Full text Link to item Cite

Combined Therapeutic Penetrating Keratoplasty and Pars Plana Vitrectomy for the Treatment of Infectious Keratitis Endophthalmitis: Mexican Endophthalmitis Study Group Protocol 4.

Journal article Cornea · July 1, 2023 PURPOSE: The purpose of this study was to assess the role of combined surgical treatment of therapeutic penetrating keratoplasty and pars plana vitrectomy in the anatomical and functional outcome of infectious keratitis endophthalmitis. METHODS: This study ... Full text Link to item Cite

Prospective, Randomized, Multicenter, Double-Masked, Clinical Trial of Corneal Cross-Linking for Boston Keratoprosthesis Carrier Tissue.

Journal article Am J Ophthalmol · May 2023 PURPOSE: To assess whether cross-linking the carrier donor cornea of the Boston Keratoprosthesis (BKPro) improves retention of the device in participants at high risk for keratolysis. DESIGN: Prospective, double-masked, randomized clinical trial. METHODS: ... Full text Link to item Cite

Efficacy and Safety of a Water-Free Topical Cyclosporine, 0.1%, Solution for the Treatment of Moderate to Severe Dry Eye Disease: The ESSENCE-2 Randomized Clinical Trial.

Conference JAMA Ophthalmol · May 1, 2023 IMPORTANCE: Dry eye disease (DED) is a common public health problem with significant impact on vision-related quality of life and well-being of patients. Medications with rapid onset of action and a good tolerability profile remain an unmet need. OBJECTIVE ... Full text Link to item Cite

Clinicopathologic analysis of conjunctivochalasis and paste-pinch-cut conjunctivoplasty for management.

Journal article Can J Ophthalmol · October 2022 OBJECTIVE: To correlate the histopathologic results of conjunctival specimens with clinical findings in patients with conjunctivochalasis and report the results of the paste-pinch-cut technique for management. DESIGN: Retrospective chart review. SETTING: S ... Full text Link to item Cite

Antibodies to Both Ro52 and Ro60 for Identifying Sjögren's Syndrome Patients Best Suited for Clinical Trials of Disease-Modifying Therapies.

Journal article Arthritis Care Res (Hoboken) · September 2022 OBJECTIVE: To assess anti-Ro52 and anti-Ro60 serologic profiles as markers of clinically relevant phenotypic subsets of patients with Sjögren's syndrome (SS). METHODS: From a cohort of 839 consecutive patients with suspected or established SS seen in our m ... Full text Link to item Cite

Symptom-Based Cluster Analysis Categorizes Sjögren's Disease Subtypes: An International Cohort Study Highlighting Disease Severity and Treatment Discordance.

Journal article Arthritis Rheumatol · September 2022 OBJECTIVE: Although symptom relief is a critical aspect for successful drug development in Sjögren's disease, patient experiences with Sjögren's-related symptoms are understudied. Our objective was to determine how pain, dryness, and fatigue, the cardinal ... Full text Link to item Cite

Reduced tear thrombospondin-1/matrix metalloproteinase-9 ratio can aid in detecting Sjögren's syndrome etiology in patients with dry eye.

Journal article Clin Transl Sci · August 2022 Differentiating patients with Sjögren's syndrome (SS)-associated dry eye from non-SS dry eye is critical for monitoring and appropriate management of possible sight- or life-threatening extraglandular complications associated with SS. We tested whether red ... Full text Link to item Cite

A comprehensive overview of living with Sjögren's: results of a National Sjögren's Foundation survey.

Journal article Clin Rheumatol · July 2022 To gain insight into the Sjögren's disease (SjD) patient experience using a survey generated by patients and providers. We evaluated the results of the 2016 Sjögren's Foundation survey, with 25 questions designed in a collaborative effort between the Found ... Full text Link to item Cite

Trends in Early Graft Failure Leading to Regrafting After Endothelial Keratoplasty in the United States.

Journal article Cornea · July 1, 2022 PURPOSE: The purpose of this study was to report trends in the prevalence of early graft failure after endothelial keratoplasty in the United States. METHODS: Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial ke ... Full text Link to item Cite

Reliability of Several Glaucoma Tests in Patients With Boston Type 1 Keratoprosthesis.

Journal article Cornea · March 1, 2022 PURPOSE: Managing glaucoma after Boston type 1 keratoprosthesis (KPro) surgery remains challenging. We herein assessed the fitness of commonly used clinical tests to evaluate glaucoma in KPro eyes versus eyes with penetrating keratoplasty (PK) as controls. ... Full text Link to item Cite

Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort

Journal article Acr Open Rheumatology · March 1, 2022 Objective: The objective of this study was to examine the association of smoking with Primary Sjögren syndrome (pSS) classification and pSS diagnostic test results. We hypothesized that past and current smokers would have lower odds of being classified as ... Full text Cite

Outcome Measures to Assess Dry Eye Severity: A Review.

Journal article Ocul Immunol Inflamm · February 17, 2022 Outcome measures used to assess efficacy of dry eye therapeutics have not been consistently applied in clinical settings, nor have they been shown to correlate with functional outcomes. We propose that corneal staining, a clinically meaningful dry eye para ... Full text Link to item Cite

Glaucoma and Ocular Surface Disease: More than Meets the Eye

Journal article Clinical Ophthalmology · January 1, 2022 Understanding the association between ocular surface disease and glaucoma is important for improving adherence to treatment and introducing practical solutions. While topical antihypertensive medications for glaucoma are well tolerated according to short-t ... Full text Cite

Surgeon Preference for Keratoplasty Techniques and Barriers to Performing Deep Anterior Lamellar Keratoplasty.

Journal article Cornea · November 1, 2021 PURPOSE: To identify barriers and facilitators to adopting deep anterior lamellar keratoplasty (DALK) for nonendothelial corneal pathology. METHODS: An anonymous survey consisting of 22 multiple choice and free text questions was designed to gather informa ... Full text Link to item Cite

Impact of COVID-19 Pandemic on Infectious Keratitis Outcomes: A Retrospective Multicenter Study in Tertiary Eye Hospitals of South India.

Journal article Cornea · November 1, 2021 PURPOSE: The purpose of this study was to report the adverse effects of the COVID-19 pandemic on the clinical outcomes of infectious keratitis in South India. METHODS: Two hundred fifty-eight patients presented with infectious keratitis at 6 tertiary care ... Full text Link to item Cite

Autologous serum eye drops for ocular surface disorders.

Journal article Curr Opin Allergy Clin Immunol · October 1, 2021 PURPOSE OF REVIEW: Ocular surface disease is a prevalent, diverse group of conditions that cause patient discomfort and decreased visual acuity and present considerable expense to both patients and healthcare systems. Autologous serum eye drops are a topic ... Full text Link to item Cite

Impact of the COVID-19 pandemic on eye strain and dry eye symptoms.

Journal article Ocul Surf · October 2021 PURPOSE: Among adult individuals with dry eye, assess the self-reported impact of the COVID-19 pandemic on (1) dry eye-related visual function, (2) reading efficiency, and (3) dry eye treatments used. METHODS: In June-July 2020, we conducted an online surv ... Full text Link to item Cite

National Sjögren's Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life.

Journal article J Rheumatol · July 2021 OBJECTIVE: To define the association between oral and systemic manifestations of Sjögren syndrome (SS) and quality of life (QOL). METHODS: We analyzed a cross-sectional survey conducted by the Sjögren's Foundation in 2016, with 2961 eligible responses. We ... Full text Link to item Cite

Neuropathic Pain in the Eyes, Body, and Mouth: Insights from the Sjögren's International Collaborative Clinical Alliance.

Journal article Pain Pract · July 2021 OBJECTIVE: To evaluate how ocular, oral, and bodily neuropathic pain symptoms, which characterize small fiber neuropathies, are associated with Sjögren's syndrome (SS) classification based on the American College of Rheumatology/European League Against Rhe ... Full text Link to item Cite

Survival of penetrating keratoplasty: a claims-based longitudinal analysis.

Journal article Can J Ophthalmol · February 2021 OBJECTIVES: To report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure. DESIGN: Retrospective longitudinal cohort study using a large commercial insurance database. ... Full text Link to item Cite

A New Screening Questionnaire to Identify Patients With Dry Eye With a High Likelihood of Having Sjögren Syndrome.

Journal article Cornea · February 1, 2021 PURPOSE: To develop a screening questionnaire to identify patients with dry eye with a high likelihood of having underlying Sjögren syndrome (SS). METHODS: This was a cross-sectional study of participants with dry eye complaints who were self-referred or r ... Full text Link to item Cite

Cicatrizing conjunctivitis as an uncommon manifestation of primary Sjögren's syndrome.

Journal article Ocul Surf · January 2021 PURPOSE: To report occurrence of cicatrizing conjunctivitis as an extraglandular ocular manifestation of primary Sjögren's syndrome (SS). METHODS: Medical charts of all patients with SS evaluated at two tertiary ophthalmological referral centers were revie ... Full text Link to item Cite

Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample.

Journal article PLoS One · 2021 PURPOSE: To assess the long-term treatment outcomes of dry eye in patients with and without underlying primary Sjögren's syndrome (SS). DESIGN: Retrospective longitudinal cohort. METHODS: SS and non-SS dry eye patients with clinic visits for a minimum of 5 ... Full text Link to item Cite

Ocular surface disease associated with dupilumab treatment for atopic diseases.

Journal article Ocul Surf · January 2021 Dupilumab is the first US FDA approved biologic for treatment of atopic dermatitis. It is a human monoclonal antibody which blocks the shared receptor component, the interleukin (IL)-4α subunit, of IL-4 and IL-13 signaling pathways. Occurrence of "conjunct ... Full text Link to item Cite

The negative effects of dry eye disease on quality of life and visual function.

Journal article Turk J Med Sci · November 3, 2020 In recent years, dry eye has become a hot topic within ophthalmology and optometry, especially in regards to new frontiers in treatment modalities which include novel devices, procedures, and medications. However, some of the more understudied areas in dry ... Full text Link to item Cite

Ocular Manifestations and Burden Related to Sjögren Syndrome: Results of a Patient Survey.

Journal article Am J Ophthalmol · November 2020 PURPOSE: To compare the burden related to dry eye with systemic symptoms of Sjögren syndrome; to estimate the burden related to ocular treatments; and to compare the impact of dry eye and extraocular manifestations of Sjögren syndrome on various aspects of ... Full text Link to item Cite

Concurrent primary Sjögren's syndrome and isolated ocular sarcoidosis presenting with bilateral corneal scarring and dry eye

Journal article American Journal of Ophthalmology Case Reports · September 1, 2020 Purpose: To report the case of a patient who presents with multiple progressive ocular diseases who is diagnosed with concurrent primary Sjögren's syndrome and isolated ocular sarcoidosis. Observation: A 60-year-old woman was referred for dry eye disease, ... Full text Cite

Differential Diagnosis of Sjögren Versus Non-Sjögren Dry Eye Through Tear Film Biomarkers.

Journal article Cornea · August 2020 PURPOSE: Systemic implications necessitate the identification of dry eye patients with Sjögren syndrome (SS). This study aims to explore the utility of tear MUC5AC and inflammatory cytokine levels in the differential diagnosis of SS-related dry eye. METHOD ... Full text Link to item Cite

Ocular Clinical Signs and Diagnostic Tests Most Compatible With Keratoconjunctivitis Sicca: A Latent Class Approach.

Journal article Cornea · August 2020 PURPOSE: To evaluate the ocular signs and tests for keratoconjunctivitis sicca (KCS) in the absence of a gold standard. METHODS: Cross-sectional study of participants from the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. Partic ... Full text Link to item Cite

Gender-Specific Trends in Ophthalmologist Medicare Collections.

Journal article Am J Ophthalmol · June 2020 PURPOSE: To assess the factors influencing the Medicare collections disparity between male and female ophthalmologists. DESIGN: Retrospective cohort study. METHODS: The Medicare Provider Utilization and Payment Data from 2012-2015 were combined with the 20 ... Full text Link to item Cite

Short-Term Clinical Outcomes of a Novel Corneal Prosthetic Device in a Rabbit Model.

Journal article Cornea · June 2020 PURPOSE: To evaluate the clinical performance and biocompatibility of a novel synthetic corneal device. METHODS: Synthetic, single-piece, foldable, suturable, optic-and-skirt design prototype devices were fabricated using expanded polytetrafluoroethylene. ... Full text Link to item Cite

Artificial corneas versus donor corneas for repeat corneal transplants.

Journal article Cochrane Database Syst Rev · May 13, 2020 BACKGROUND: Individuals who have failed one or more full thickness penetrating keratoplasties may be offered repeat corneal surgery using an artificial or donor cornea. An artificial or prosthetic cornea is known as a keratoprosthesis. Both donor and artif ... Full text Link to item Cite

Sustained Gazing Causes Measurable Decline in Visual Function of Patients with Dry Eye.

Journal article Am J Ophthalmol · February 2020 PURPOSE: To assess the effects of sustained gazing on visual function of dry eye patients. DESIGN: Prospective, comparative before-and-after study. METHODS: A total of 176 patients with dry eye and 33 control subjects ≥50 years old were included. Dry eye s ... Full text Link to item Cite

Characterization of Progressive Cicatrizing Conjunctivitis With Negative Immunofluorescence Staining.

Journal article Am J Ophthalmol · January 2020 PURPOSE: To characterize the clinical features of patients with direct immunofluorescence (DIF)-negative mucous membrane pemphigoid (MMP). DESIGN: Retrospective case series. METHODS: Thirty-six patients who underwent a conjunctival biopsy for suspected MMP ... Full text Link to item Cite

Extraglandular ocular involvement and morbidity and mortality in primary Sjögren's Syndrome.

Journal article PLoS One · 2020 PURPOSE: To report the significance of extraglandular ocular involvement and long-term systemic morbidity and mortality in primary Sjögren's Syndrome (SS). METHODS: This retrospective, longitudinal cohort study included consecutive patients with primary SS ... Full text Link to item Cite

Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease.

Journal article Cochrane Database Syst Rev · December 18, 2019 BACKGROUND: Polyunsaturated fatty acid (PUFA) supplements, involving omega-3 and/or omega-6 components, have been proposed as a therapy for dry eye. Omega-3 PUFAs exist in both short- (alpha-linolenic acid [ALA]) and long-chain (eicosapentaenoic acid [EPA] ... Full text Link to item Cite

Topical cyclosporine A therapy for dry eye syndrome.

Journal article Cochrane Database Syst Rev · September 13, 2019 BACKGROUND: Topical cyclosporine A (also known as ciclosporin A) (CsA) is an anti-inflammatory that has been widely used to treat inflammatory ocular surface diseases. Two CsA eyedrops have been approved by US Food and Drug Administration for managing dry ... Full text Link to item Cite

Conjunctivitis in dupilumab clinical trials.

Journal article Br J Dermatol · September 2019 BACKGROUND: Dupilumab blocks the shared receptor component for interleukin (IL)-4 and IL-13. It is approved in the U.S.A. for patients aged ≥ 12 years with moderate-to-severe atopic dermatitis (AD) uncontrolled by topical prescription medicines or who cann ... Full text Link to item Cite

Sjögren's Syndrome: More Than Just Dry Eye.

Journal article Cornea · May 2019 PURPOSE: Sjögren's syndrome (SS) is a common autoimmune disease affecting about four million Americans. Although approximately 1 in 10 patients with clinically-significant aqueous deficient dry eye has underlying SS, widespread underappreciation of SS lead ... Full text Link to item Cite

Immunopathological Features of Severe Chronic Atopic Keratoconjunctivitis and Effects of Topical Cyclosporine Treatment.

Journal article Ocul Immunol Inflamm · 2019 PURPOSE: To assess differential roles of inflammatory cells in pathophysiology of severe atopic keratoconjunctivitis (AKC) and evaluate immunomodulatory effects of topical cyclosporine A (CsA). METHODS: A total of 10 patients with severe, steroid-dependent ... Full text Link to item Cite

Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye.

Journal article J Immunol Res · 2019 BACKGROUND: Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for ... Full text Link to item Cite

Long-term clinical outcomes of keratoplasty using gamma-irradiated corneal lenticules.

Journal article BMJ Open Ophthalmol · 2019 OBJECTIVE: To report long-term clinical outcomes of gamma-irradiated corneal lenticules in partial and full-thickness keratoplasty. METHODS AND ANALYSIS: This multicentre, retrospective case series includes 23 patients who underwent surgery at three centre ... Full text Link to item Cite

Dry Eye Syndrome Preferred Practice Pattern®.

Journal article Ophthalmology · January 2019 Full text Link to item Cite

Bacterial Keratitis Preferred Practice Pattern®.

Journal article Ophthalmology · January 2019 Full text Link to item Cite

Corneal Ectasia Preferred Practice Pattern®.

Journal article Ophthalmology · January 2019 Full text Link to item Cite

Conjunctivitis Preferred Practice Pattern®.

Journal article Ophthalmology · January 2019 Full text Link to item Cite

Blepharitis Preferred Practice Pattern®.

Journal article Ophthalmology · January 2019 Full text Link to item Cite

Impact of Dry Eye on Prolonged Reading.

Journal article Optom Vis Sci · December 2018 SIGNIFICANCE: Patients with dry eye frequently report difficulty with reading. However, the impact of dry eye on reading has not been studied in detail. This study shows the unfavorable effect of dry eye on reading speed and offers mechanisms that may be r ... Full text Link to item Cite

Research Questions and Outcomes Prioritized by Patients With Dry Eye.

Journal article JAMA Ophthalmol · October 1, 2018 IMPORTANCE: Dry eye is a common ocular surface condition with significant influence on patient quality of life and societal economic burden. There is an urgent need to prioritize new research for dry eye. OBJECTIVE: To identify and rank research questions ... Full text Link to item Cite

Effects of Prolonged Reading on Dry Eye.

Journal article Ophthalmology · October 2018 PURPOSE: To demonstrate the effects of prolonged silent reading on tear film and ocular surface parameters. DESIGN: Prospective, observational clinical study. PARTICIPANTS: A total of 177 patients with dry eye and 34 normal controls aged 50 years and older ... Full text Link to item Cite

Validation of an objective measure of dry eye severity

Journal article Translational Vision Science and Technology · September 1, 2018 Purpose: We evaluated the validity of a single dry eye severity measure estimated using Rasch analysis from a battery of clinical tests and patient symptoms. Methods: This study included 203 dry eye patients and 51 controls. Administered tests included the ... Full text Cite

Etiology of Global Corneal Blindness and Current Practices of Corneal Transplantation: A Focused Review.

Journal article Cornea · September 2018 PURPOSE: The purpose of this focused review was to explore the etiologies of corneal blindness worldwide and compare them with the indications and type of keratoplasties (eg, full-thickness penetrating keratoplasty, anterior lamellar keratoplasty, or endot ... Full text Link to item Cite

Utility of Novel Autoantibodies in the Diagnosis of Sjögren's Syndrome Among Patients With Dry Eye.

Journal article Cornea · April 2018 PURPOSE: To investigate the value of 3 novel autoantibodies [salivary protein 1 (SP1), carbonic anhydrase 6 (CA6), and parotid secretory protein (PSP)] in differentiating Sjögren's syndrome (SS)-related dry eye from non-SS dry eye. METHODS: Forty-six dry e ... Full text Link to item Cite

Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities.

Journal article Cornea · February 2018 PURPOSE: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. METHODS: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. RESULTS: Corneal blindness from chemical ... Full text Link to item Cite

Natural History and Predictors of Progression to Sjögren's Syndrome Among Participants of the Sjögren's International Collaborative Clinical Alliance Registry.

Journal article Arthritis Care Res (Hoboken) · February 2018 OBJECTIVE: To explore changes in the phenotypic features of Sjögren's syndrome (SS), and in SS status among participants in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry over a 2-3-year interval. METHODS: All participants in ... Full text Link to item Cite

Gaps in Current Knowledge and Priorities for Future Research in Dry Eye.

Journal article Cornea · December 2017 PURPOSE: Dry eye, a common yet underrecognized and evolving field, has few recommended treatment algorithms, mostly based on expert consensus rather than robust research evidence. There are high costs associated with managing dry eye and conducting researc ... Full text Link to item Cite

Tear Osmolarity and Correlation With Ocular Surface Parameters in Patients With Dry Eye.

Journal article Cornea · November 2017 PURPOSE: To analyze the distribution of tear film osmolarity in patients with dry eye and its association with other ocular surface parameters. METHODS: Tear osmolarity and other quantitative dry eye parameters were obtained from patients with 1) clinicall ... Full text Link to item Cite

TFOS DEWS II Introduction.

Journal article Ocul Surf · July 2017 Full text Link to item Cite

TFOS DEWS II Definition and Classification Report.

Journal article Ocul Surf · July 2017 The goals of the TFOS DEWS II Definition and Classification Subcommittee were to create an evidence-based definition and a contemporary classification system for dry eye disease (DED). The new definition recognizes the multifactorial nature of dry eye as a ... Full text Link to item Cite

Functional impairment of reading in patients with dry eye.

Journal article Br J Ophthalmol · April 2017 BACKGROUND/AIMS: To evaluate the impact of dry eye on reading performance. METHODS: Out-loud and silent reading in patients with clinically significant dry eye (n=41) and controls (n=50) was evaluated using standardised texts. Dry eye measures included tea ... Full text Link to item Cite

Autologous serum eye drops for dry eye.

Journal article Cochrane Database Syst Rev · February 28, 2017 BACKGROUND: Theoretically, autologous serum eye drops (AS) offer a potential advantage over traditional therapies on the assumption that AS not only serve as a lacrimal substitute to provide lubrication but contain other biochemical components that allow t ... Full text Link to item Cite

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts.

Journal article Arthritis Rheumatol · January 2017 OBJECTIVE: To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were ... Full text Link to item Cite

Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry.

Journal article Am J Ophthalmol · December 2016 PURPOSE: To identify a screening strategy for dry eye patients with a high likelihood of having Sjogren syndrome (SS) through the evaluation of the association of ocular surface tests with the extraocular signs used for the diagnosis of SS. DESIGN: Multice ... Full text Link to item Cite

Treating Infectious Keratitis.

Journal article Ocul Immunol Inflamm · October 2016 Full text Link to item Cite

The Usage of a Conjunctival Flap to Improve Retention of Boston Type 1 Keratoprosthesis in Severe Ocular Surface Disease.

Journal article Ocul Immunol Inflamm · October 2016 PURPOSE: The Boston keratoprostheses type 1 devices (KPro) are utilized in cases unfavorable to penetrating keratoplasty. The prognosis remains guarded in cases of ocular surface disease due to risk of tissue necrosis. We describe a novel surgical approach ... Full text Link to item Cite

A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome.

Journal article Laryngoscope · September 2016 OBJECTIVES/HYPOTHESIS: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). STUDY DESIGN: Prospective cohort study. METHODS: Clinical data were prospectively obtained pre- and ... Full text Link to item Cite

Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease.

Journal article Ocul Surf · April 2016 Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN ... Full text Link to item Cite

Frequent Dosing of Topical Cyclosporine A for Severe Ocular Surface Disease.

Journal article J Ocul Pharmacol Ther · April 2016 PURPOSE: To study the systemic safety and patient tolerability of frequent dosing of cyclosporine A (CsA) 0.05% eyedrops in the treatment of ocular surface disease. This is a retrospective case series. Patients with significant ocular surface diseases who ... Full text Link to item Cite

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease.

Journal article Ocul Surf · January 2016 The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TE ... Full text Link to item Cite

Boston Type 1 Keratoprosthesis versus Repeat Donor Keratoplasty for Corneal Graft Failure: A Systematic Review and Meta-analysis.

Journal article Ophthalmology · January 2016 PURPOSE: To compare repeat penetrating keratoplasty (PK) with Boston type I keratoprosthesis (KPro) implantation for full-thickness donor corneal graft failure. DESIGN: Previous donor graft failure is a common indication for both PK and KPro implantation. ... Full text Link to item Cite

Outcomes of Repeat Boston Type 1 Keratoprosthesis Implantation.

Journal article Am J Ophthalmol · January 2016 PURPOSE: To describe the outcomes and prognostic characteristics of patients who had a repeat Boston type 1 keratoprosthesis (KPro) implantation. DESIGN: Retrospective case series. METHODS: setting: Data regarding preoperative clinical and demographic char ... Full text Link to item Cite

Inter-grader Agreement of the Ocular Staining Score in the Sjögren's International Clinical Collaborative Alliance (SICCA) Registry.

Journal article Am J Ophthalmol · December 2015 PURPOSE: To determine the intra-observer and inter-observer reliability of a novel ocular staining score among trained ophthalmologists. DESIGN: Reliability analysis within a prospective, observational, multicenter cohort study. METHODS: Those enrolled in ... Full text Link to item Cite

Ocular complications of primary Sjögren syndrome in men.

Journal article Am J Ophthalmol · September 2015 PURPOSE: To report the ocular complications of primary Sjögren syndrome (SS) in men. DESIGN: Retrospective cohort study. METHODS: setting: Tertiary-care SS center. PATIENT POPULATION: Total of 163 consecutive primary Sjögren syndrome patients evaluated bet ... Full text Link to item Cite

Sarcoidosis Presenting with Cicatrizing Conjunctivitis.

Journal article Optom Vis Sci · August 2015 PURPOSE: To report two patients with sarcoidosis initially presenting with cicatrizing conjunctivitis. CASE REPORTS: Both patients with chronic conjunctivitis were referred for further management. The first patient had conjunctival granulomas, subepithelia ... Full text Link to item Cite

The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome.

Journal article Ann Rheum Dis · August 2015 OBJECTIVE: To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS. METHODS: Among registrants in the Sjögren's International Collaborative Clinical ... Full text Link to item Cite

Author reply: To PMID 25017414.

Journal article Ophthalmology · May 2015 Full text Link to item Cite

Predictors of visual outcomes following Boston type 1 keratoprosthesis implantation.

Journal article Am J Ophthalmol · April 2015 PURPOSE: To identify predictors of visual outcomes following Boston type 1 Keratoprosthesis (KPro) implantation. DESIGN: Retrospective chart review. METHODS: Data regarding preoperative clinical and demographic characteristics and postoperative course were ... Full text Link to item Cite

Evaluation of broadband spectral transmission characteristics of fresh and gamma-irradiated corneal tissues.

Journal article Cornea · February 2015 PURPOSE: The aim of this study was to evaluate the clarity of gamma-irradiated sterile corneal donor lenticules. METHODS: Broadband UV, visible, and near-infrared (200-850 nm) light transmission was measured through gamma-irradiated, sterile partial-thickn ... Full text Link to item Cite

Boston KPro Type I in the Pediatric Age Group

Book section · January 1, 2015 Corneal opacity in pediatric patients may be congenital or acquired. Significant corneal opacities in infants can lead to profound deprivation amblyopia. For this reason, early surgical intervention to provide a clear visual axis is recommended. Surgery us ... Full text Cite

Donor Corneal Transplantation vs Boston Type 1 Keratoprosthesis in Patients with Previous Graft Failures: A Retrospective Single Center Study (An American Ophthalmological Society Thesis).

Journal article Trans Am Ophthalmol Soc · 2015 PURPOSE: To compare short-term outcomes of repeat penetrating keratoplasty (PK) to those of Boston type 1 keratoprosthesis (KPro). Our hypothesis was that visual outcomes were superior for KPro compared to PK. METHODS: This is a retrospective, nonrandomize ... Link to item Cite

Ocular and systemic morbidity in a longitudinal cohort of Sjögren's syndrome.

Journal article Ophthalmology · January 2015 PURPOSE: To report vision-threatening ocular manifestations of primary Sjögren's syndrome (SS). DESIGN: Retrospective review. PARTICIPANTS: Consecutive patients evaluated at an SS center between January 2007 and May 2011. METHODS: Data collection was compl ... Full text Link to item Cite

Artificial corneas versus donor corneas for repeat corneal transplants.

Journal article Cochrane Database Syst Rev · November 5, 2014 BACKGROUND: Individuals who have failed one or more full thickness penetrating keratoplasties (PKs) may be offered repeat corneal surgery using an artificial or donor cornea. An artificial or prosthetic cornea is known as a keratoprosthesis. Both donor and ... Full text Link to item Cite

Long-term outcomes of boston type 1 keratoprosthesis implantation: a retrospective multicenter cohort.

Journal article Ophthalmology · November 2014 PURPOSE: To study the long-term outcomes of Boston type 1 keratoprosthesis (KPro) surgery. DESIGN: Retrospective, multicenter case series. PARTICIPANTS: A total of 158 eyes of 150 patients underwent KPro implantation at 5 participating tertiary centers in ... Full text Link to item Cite

Association of dry eye and inflammatory systemic diseases in a tertiary care-based sample.

Journal article Cornea · August 2014 PURPOSE: The aim of this study was to review the frequency and types of inflammatory systemic diseases in a cohort of patients with dry eye, and identify clinical features suggesting the presence of these. METHODS: Consecutive new patients with a primary d ... Full text Link to item Cite

Sarcoidosis presenting as scleral nodule.

Journal article Ocul Immunol Inflamm · August 2014 Full text Link to item Cite

No increase in IgG4-positive plasma cells in limbal Rosai-Dorfman disease.

Journal article Cornea · August 2014 PURPOSE: Extranodal Rosai-Dorfman disease is a rare benign condition recently reported to sometimes show features of IgG4-related disease. The purpose of this study was to describe the corneal-limbal manifestation of the entity and to investigate whether n ... Full text Link to item Cite

Impact of dry eye on reading in a population-based sample of the elderly: the Salisbury Eye Evaluation.

Journal article Br J Ophthalmol · May 2014 BACKGROUND/AIMS: People with dry eye often complain of difficulty reading, but this perceived deficit has not been appropriately quantified. The purpose of this study is to determine if dry eye is associated with measurable reading deficits. METHODS: A cro ... Full text Link to item Cite

Omega-3 and omega-6 polyunsaturated fatty acids for dry eye syndrome

Journal article Cochrane Database of Systematic Reviews · March 6, 2014 This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effect of omega-3 and omega-6 PUFAs on the signs and symptoms of patients with dry eye, and to document any treatment-related adverse events. ... Full text Cite

Dry eye: An inflammatory ocular disease

Journal article Journal of Ophthalmic and Vision Research · January 1, 2014 Keratoconjunctivitis sicca, or dry eye, is a common ocular disease prompting millions of individuals to seek ophthalmological care. Regardless of the underlying etiology, dry eye has been shown to be associated with abnormalities in the pre-corneal tear fi ... Cite

Evaluation of ocular surface disease in patients with glaucoma.

Journal article Ophthalmology · November 2013 PURPOSE: To evaluate the subjective and objective measures of ocular surface disease in patients with glaucoma. DESIGN: Cross-sectional study. PARTICIPANTS: Sixty-four glaucoma subjects with bilateral visual field (VF) loss and 59 glaucoma suspects with no ... Full text Link to item Cite

Autologous serum eye drops for dry eye.

Journal article Cochrane Database Syst Rev · August 27, 2013 BACKGROUND: =Theoretically, autologous serum eye drops (AS) have a potential advantage over traditional therapies based on the assumption that ASserve not only as a lacrimal substitute to provide lubrication, but also contain other biochemical components m ... Full text Link to item Cite

Current treatment strategies for age-related ocular conditions.

Journal article Am J Manag Care · May 2013 Treatment for several major age-related ocular diseases has undergone a paradigm shift in recent years. Advances in basic science and clinical research have led to a more thorough understanding of the complex pathophysiology underlying common ocular diseas ... Link to item Cite

Overview of age-related ocular conditions.

Journal article Am J Manag Care · May 2013 The United States is an aging society. The number of Americans 65 years or older is expected to more than double over the next 40 years, from 40.2 million in 2010 to 88.5 million in 2050, with aging baby boomers accounting for most of the increase. As the ... Link to item Cite

Necrotizing scleritis as a complication of cosmetic eye whitening procedure

Journal article Journal of Ophthalmic Inflammation and Infection · January 1, 2013 Background: We report necrotizing scleritis as a serious complication of a cosmetic eye whitening procedure that involves the use of intraoperative and postoperative topical mitomycin C. Findings: This is a single case report. A 59-year-old Caucasian male ... Full text Cite

Prevalence and predictors of Sjogren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye.

Journal article Br J Ophthalmol · December 2012 AIMS: To assess the prevalence and determine predictors of Sjögren's syndrome (SS) in patients with clinically significant aqueous-deficient dry eye. METHODS: Patients enrolled in an industry-sponsored, multicentre clinical trial (NCT00784719) were assesse ... Full text Link to item Cite

Mucous membrane pemphigoid: recent advances.

Journal article Curr Opin Ophthalmol · November 2012 PURPOSE OF REVIEW: This review article summarizes the recent literature in regards to advancements in the diagnosis and management of mucous membrane pemphigoid (MMP) published in the English literature since May 2011. RECENT FINDINGS: MMP is an uncommon, ... Full text Link to item Cite

Ocular graft-versus-host disease.

Journal article Curr Opin Allergy Clin Immunol · October 2012 PURPOSE OF REVIEW: This review was carried out to study the frequency, and severity of ocular surface involvement at the setting of allogeneic hematopoietic stem cell transplantation and subsequent graft-versus-host disease (GVHD) and evaluate the clinical ... Full text Link to item Cite

Chronic hypotony associated with the Boston type 1 keratoprosthesis.

Journal article Am J Ophthalmol · August 2012 PURPOSE: To report the occurrence of chronic hypotony as a complication following Boston type 1 keratoprosthesis (KPro) implantation and to determine associated risk factors. DESIGN: Retrospective case series. METHODS: The medical records of all patients u ... Full text Link to item Cite

Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis.

Journal article Cornea · June 2012 PURPOSE: To evaluate the long-term effectiveness of the combination of topical cyclosporine drops and tacrolimus ointment in the treatment of steroid-dependent atopic keratoconjunctivitis (AKC). METHODS: Ten patients with moderate to severe AKC participate ... Full text Link to item Cite

Interventions for chronic blepharitis.

Journal article Cochrane Database Syst Rev · May 16, 2012 BACKGROUND: Blepharitis, an inflammatory condition associated with itchiness, redness, flaking, and crusting of the eyelids, is a common eye condition that affects both children and adults. It is common in all ethnic groups and across all ages. Although in ... Full text Link to item Cite

Boston type 1 keratoprosthesis implantation in traumatic stem cell deficiency and keratoplasty rejection

Journal article Turk Oftalmoloiji Dergisi · April 6, 2012 A 31-year-old male patient was admitted with the complaint of decreased vision in both eyes. He underwent multiple pars plana vitrectomy and silicone oil injection operations due to bilateral retina detachment after rocket projectile explosion in his hands ... Full text Cite

The use of precut, γ-irradiated corneal lenticules in Boston type 1 keratoprosthesis implantation

Journal article American Journal of Ophthalmology · January 1, 2012 Purpose: To report the use of a sterile, γ-irradiated corneal tissue without viable endothelium (VisionGraft Sterile Cornea; Tissue Banks International) in lieu of fresh donor cornea in Boston type 1 keratoprosthesis (KPro) implantation. Design: Retrospect ... Full text Cite

The intraoperative impression and postoperative outcomes of gamma-irradiated corneas in corneal and glaucoma patch surgery.

Journal article Cornea · December 2011 PURPOSE: To report the short-term outcome of gamma-irradiated sterile cornea in corneal and glaucoma patch graft surgeries when viable endothelium is not necessary. METHODS: Surgeons who have used the irradiated corneas were asked to rate their impression ... Full text Link to item Cite

Clinical features and prognosis of Boston type I keratoprosthesis-associated corneal melt.

Journal article Ocul Immunol Inflamm · December 2011 PURPOSE: To describe the clinical features and outcomes of corneal melt associated with Boston type I keratoprosthesis (KPro) implantation. METHODS: Medical records of patients who experienced corneal melt following KPro implantation were reviewed retrospe ... Full text Link to item Cite

Visual and clinical outcomes of explantation versus preservation of the intraocular lens during keratoprosthesis implantation.

Journal article J Cataract Refract Surg · September 2011 PURPOSE: To compare the short-term visual and clinical outcomes of explantation versus preservation of a posterior chamber intraocular lens (PC IOL) during keratoprosthesis implantation. SETTING: Wilmer Eye Institute, Johns Hopkins University, Baltimore, M ... Full text Link to item Cite

Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.

Journal article Ophthalmology · July 2011 BACKGROUND: Outcomes-based review of reported treatment options for patients with dry eye secondary to Sjögren's syndrome (SS). CLINICAL RELEVANCE: Dry eye affects many individuals worldwide. Significant proportion of patients with dry eye has underlying S ... Full text Link to item Cite

Lamellar keratoplasty using gamma-irradiated corneal lenticules

Journal article American Journal of Ophthalmology · January 1, 2011 Purpose To report the clinical outcomes of lamellar keratoplasty using sterile, gamma-irradiated corneal tissues (VisionGraft) for partial-thickness corneal defects. Design Interventional case series. Methods The medical records of 10 patients with partial ... Full text Cite

Post-surgical volumetric evaluation of clear corneal incision quality using a high-resolution 3-D spectral-domain optical coherence tomography

Conference Optics Infobase Conference Papers · December 1, 2010 A novel approach for post-surgical volumetric evaluation of the quality of corneal incisions and wound healing is presented. It is based on high-resolution 3-D spectral-domain optical coherence tomography providing both multiple-cross-sectional and volumet ... Cite

Permanent keratoprosthesis combined with pars plana vitrectomy and silicone oil injection for visual rehabilitation of chronic hypotony and corneal opacity.

Journal article Cornea · December 2010 PURPOSE: To present outcomes of combined pars plana vitrectomy, silicone oil (SO) injection, and permanent keratoprosthesis (Kpro) procedure in prephthisical eyes. METHODS: All 3 patients were monocular with chronic severe hypotony, aphakia, and total corn ... Full text Link to item Cite

Noninvasive volumetric quality evaluation of post-surgical clear corneal incision via high-resolution Fourier-domain optical coherence tomography

Journal article Electronics Letters · October 28, 2010 A novel approach for post-surgical evaluation of clear corneal incision quality is presented. The complete volumetric information of an ex-vivo bovine cornea with incision and suture is obtained by high-resolution Fourier-domain optical coherence tomograph ... Full text Cite

Post-surgical volumetric evaluation of clear corneal incision quality using a high-resolution 3-D spectral-domain optical coherence tomography

Conference Lasers and Electro Optics Quantum Electronics and Laser Science Conference 2010 Laser Science to Photonic Applications CLEO QELS 2010 · October 11, 2010 A novel approach for post-surgical volumetric evaluation of the quality of corneal incisions and wound healing is presented. It is based on high-resolution 3-D spectral-domain optical coherence tomography providing both multiple-cross-sectional and volumet ... Cite

Clinical review: topical ophthalmic use of cyclosporin A.

Journal article Ocul Immunol Inflamm · October 2010 Cyclosporine A (CsA) is an immunomodulatory agent that primarily inhibits the proliferation and action of T cells. Systemic CsA has been used successfully in solid organ transplantation and noninfectious uveitis. Topical CsA with various formulations has b ... Full text Link to item Cite

Crescenteric amniotic membrane grafting in keratoprosthesis-associated corneal melt.

Journal article Arch Ophthalmol · June 2010 We herein present a surgical technique for the management of corneal melt following Boston type I keratoprosthesis implantation. The technique was performed using new-generation dehydrated human amniotic membrane. The membrane was fashioned in the shape of ... Full text Link to item Cite

Short-term visual outcomes of Boston type 1 keratoprosthesis implantation.

Journal article Ophthalmology · April 2010 PURPOSE: To report the short-term visual outcomes after keratoprosthesis implantation. DESIGN: Retrospective multi center case series (Wilmer Eye Institute and University of Rochester Eye Institute). PARTICIPANTS: One hundred twenty-two patients (126 eyes) ... Full text Link to item Cite

Autoimmune hepatitis in patients with primary Sjögren's syndrome: a series of two-hundred and two patients.

Journal article Int J Clin Exp Pathol · March 25, 2010 Based on the revised criteria of the American-European Consensus Group, we retrospectively established the diagnosis of primary or secondary Sjögren's syndrome for 202 patients referred to a Sjögren's syndrome clinic. Of these, 58 patients and 8 patients f ... Link to item Cite

Use of a microvascular clip for iris fixation of an intraocular lens: a laboratory model.

Journal article Arch Ophthalmol · January 2010 Here we present a potential novel surgical technique consisting of fixation of a posterior-chamber intraocular lens to the iris that may be used in the treatment of aphakia or the management of intraocular lens complications when capsular support has been ... Full text Link to item Cite

Ocular surface distribution and pharmacokinetics of a novel ophthalmic 1% azithromycin formulation.

Journal article J Ocul Pharmacol Ther · October 2009 PURPOSE: To investigate the ocular distribution of 1% azithromycin ophthalmic solution and the effect of polycarbophil-based mucoadhesive formulation on ocular tissue levels of azithromycin after single and multiple topical administrations in the rabbit ey ... Full text Link to item Cite

Glaucoma and dry eye.

Journal article Ophthalmology · June 2009 Full text Link to item Cite

Evaluation of patients with dry eye for presence of underlying Sjögren syndrome.

Journal article Cornea · June 2009 PURPOSE: To evaluate the rate of Sjögren syndrome (SS) in a cohort of patients with dry eye syndrome. METHODS: Medical records of patients with a primary diagnosis of dry eye syndrome (International Classification of Diseases [ICD] code 375.15 or 370.33) w ... Full text Link to item Cite

Occult thyroid eye disease in patients presenting with dry eye symptoms.

Journal article Am J Ophthalmol · May 2009 PURPOSE: To describe the clinical presentation, laboratory features, and treatment outcomes in a series of patients with occult thyroid eye disease (TED). DESIGN: Retrospective observational case series. METHODS: Among 539 patients who were referred for dr ... Full text Link to item Cite

Electron microscopic investigation of the lens capsule and conjunctival tissues in individuals with clinically unilateral pseudoexfoliation syndrome.

Journal article Ophthalmology · April 2008 PURPOSE: To determine the presence of pseudoexfoliative material in the unaffected eyes of patients with clinically unilateral pseudoexfoliation syndrome. DESIGN: Prospective observational case series. PARTICIPANTS: Thirty-two consecutive patients with cli ... Full text Link to item Cite

Permanent keratoprostheses

Book section · January 1, 2008 Full text Cite

Pediatric keratoplasty

Journal article Expert Review of Ophthalmology · January 1, 2008 Corneal transplantation in a pediatric patient population poses special challenges that are not encountered in adults. The surgical procedure is technically more complex because of the small size of the globe, reduced rigidity of the cornea and sclera, and ... Full text Cite

Gatifloxacin ophthalmic solution 0.3% in the treatment of bacterial keratitis

Journal article Expert Review of Ophthalmology · January 1, 2008 Infectious keratitis can be a medical emergency that can lead to a profound loss of vision if not treated promptly and appropriately. Although a shift in the etiology and predisposing factors has been reported within the past few years, bacteria still pred ... Full text Cite

Autoimmune Th2-mediated dacryoadenitis in MRL/MpJ mice becomes Th1-mediated in IL-4 deficient MRL/MpJ mice.

Journal article Invest Ophthalmol Vis Sci · December 2007 PURPOSE: MRL/MpJ mice of substrains MRL/MpJ-fas(+)/fas(+) (MRL/+) and MRL/MpJ-fas(lpr)/fas(lpr) (MRL/lpr) spontaneously develop autoimmune dacryoadenitis and sialadenitis and are a model for the human disorder Sjögren syndrome. The dacryoadenitis in both s ... Full text Link to item Cite

Histopathologic and immunologic aspects of alphacor artificial corneal failure.

Journal article Am J Ophthalmol · November 2007 PURPOSE: To describe the histopathologic and immunologic characteristics of late artificial corneal failure in a small series of patients who underwent AlphaCor implantation and to elucidate the mechanisms involved. DESIGN: Clinicopathologic case series. M ... Full text Link to item Cite

Outcomes of Boston keratoprosthesis in aniridia: a retrospective multicenter study.

Journal article Am J Ophthalmol · August 2007 PURPOSE: To evaluate the long-term outcomes of keratoprosthesis as an alternative surgical procedure in the management of aniridic keratopathy. DESIGN: Retrospective, multicenter case series. METHODS: Fifteen adult patients (16 eyes) with aniridia who were ... Full text Link to item Cite

Pediatric keratoprosthesis.

Journal article Ophthalmology · May 2007 OBJECTIVE: To describe the authors' experience using keratoprosthesis to treat pediatric corneal opacity. DESIGN: Nonrandomized, consecutive, retrospective interventional series. PARTICIPANTS: Twenty-two eyes of 17 children with opaque corneas as a result ... Full text Link to item Cite

Subluxation of suture-fixated posterior chamber intraocular lenses a clinicopathologic study.

Journal article Ophthalmology · February 2007 PURPOSE: To report the occurrence of subluxation of suture-fixated posterior chamber (PC) intraocular lenses (IOL) and elucidate the mechanisms involved. DESIGN: Prospective clinicopathologic study. PARTICIPANTS: A single 10-0 Prolene suture explanted from ... Full text Link to item Cite

Isolated lichen planus of the conjunctiva.

Journal article Br J Ophthalmol · October 2006 Full text Link to item Cite

Topical ciclosporin in the treatment of ocular surface disorders.

Journal article Br J Ophthalmol · October 2005 Mounting evidence suggests that inflammation is the key factor in the pathogenesis of various ocular surface diseases, with a complex interplay of genetic, environmental, and psychosocial factors. Management of these conditions is often challenging. Topica ... Full text Link to item Cite

Current concepts and techniques in keratoprosthesis.

Journal article Curr Opin Ophthalmol · August 2005 PURPOSE OF REVIEW: Diseases affecting the cornea are a major cause of blindness worldwide, second only to cataract in overall importance, with an estimated 10 to 15 million affected people. Although keratoplasty is by far the most successful transplantatio ... Full text Link to item Cite

Subluxation of iris-sutured intraocular lenses and results of a closed chamber technique for repositioning after penetrating keratoplasty.

Journal article Cornea · May 2005 PURPOSE: To describe subluxation of iris-fixated intraocular lenses (IOLs) after penetrating keratoplasty (PK) as a postoperative complication and report the long-term outcomes of a closed-chamber refixation technique used in the management. METHODS: This ... Full text Link to item Cite

Lack of herpes virus DNA in choroidal tissues of a patient with serpiginous choroiditis.

Journal article Ophthalmology · November 2004 OBJECTIVE: To investigate the role of herpes viruses in the etiology of serpiginous choroiditis. DESIGN: Interventional case report. PARTICIPANT: A 59-year-old male patient with long-term history of serpiginous choroiditis. INTERVENTION: The patient's affe ... Full text Link to item Cite

Inflammatory mediators in autoimmune lacrimal gland disease in MRL/Mpj mice.

Journal article Invest Ophthalmol Vis Sci · July 2004 PURPOSE: MRL/MpJ-fas(+)/fas(+) (MRL/+) and MRL/MpJ-fas(lpr)/fas(lpr) (MRL/lpr) mice are congenic substrains of mice that have spontaneously developing lacrimal and salivary gland inflammation and are models for the human disorder Sjögren's syndrome. Nitric ... Full text Link to item Cite

Evaluation of patients with scleritis for systemic disease.

Journal article Ophthalmology · March 2004 OBJECTIVE: To evaluate the relationship between associated medical conditions and scleritis-particularly, the timing of the diagnosis of these diseases. DESIGN: Retrospective case series. PARTICIPANTS: Patients with scleritis presenting to a single center ... Full text Link to item Cite

A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis.

Journal article Ophthalmology · March 2004 OBJECTIVE: To evaluate the short-term efficacy and safety of topical cyclosporin A 0.05% in the treatment of patients with severe, steroid-resistant atopic keratoconjunctivitis (AKC). DESIGN: Multicenter, placebo-controlled, double-masked, randomized trial ... Full text Link to item Cite

Chemokines in autoimmune lacrimal gland disease in MRL/MpJ mice.

Journal article Invest Ophthalmol Vis Sci · January 2004 PURPOSE: MRL/MpJ-fas+/fas+ (MRL/+) and MRL/MpJ-fas(lpr)/fas(lpr) (MRL/lpr) mice undergo spontaneous development of inflammation of the lacrimal and salivary glands, similar to that in the human disorder Sjögren's syndrome. Previous work has shown that thes ... Full text Link to item Cite

Immune defense at the ocular surface.

Journal article Eye (Lond) · November 2003 The ocular surface is constantly exposed to a wide array of microorganisms. The ability of the outer ocular system to recognize pathogens as foreign and eliminate them is critical to retain corneal transparency, hence preservation of sight. Therefore, a co ... Full text Link to item Cite

New treatments for serpiginous choroiditis.

Journal article Curr Opin Ophthalmol · June 2003 Serpiginous choroiditis is a bilateral, inflammatory condition of the inner choroid and overlying retinal pigment epithelium with a distinctive retinal distribution. Although rare, serpiginous choroiditis deserves attention because it can lead to permanent ... Full text Link to item Cite

Identification of paramyosin as a binding protein for calgranulin C in experimental helminthic keratitis.

Journal article Invest Ophthalmol Vis Sci · August 2002 PURPOSE: Calgranulin C (CaGC) is a protein released by activated neutrophils and involved in host defense against filarial infections. This study involved the identification of binding protein(s) of the helminth Brugia malayi to CaGC and the ability of bin ... Link to item Cite

Successful treatment of serpiginous choroiditis with alkylating agents.

Journal article Ophthalmology · August 2002 OBJECTIVE: To describe the management and long-term outcomes of patients with serpiginous choroiditis treated with alkylating agents. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: Nine patients with active, vision-threatening serpiginous ... Full text Link to item Cite

Endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning (edict) syndrome maps to chromosome 15q22.1-q25.3.

Journal article Am J Ophthalmol · August 2002 PURPOSE: To localize a gene causing a newly described autosomal dominant anterior segment dysgenesis characterized by corneal endothelial dystrophy, iris hypoplasia, congenital cataracts, and corneal stromal thinning (EDICT syndrome). DESIGN: Experimental ... Full text Link to item Cite

Corneal stability and biomechanics after LASIK

Book section · January 1, 2002 A. BIOMECHANICAL PROPERTIES OF THE CORNEA The elastic properties of any material are described by the relationship between the applied stress, or force per unit cross section, and the resultant strain, or relative deformation. The proportionality factor, Y ... Cite

Spontaneous corneal perforation in a patient with unusual unilateral pellucid marginal degeneration.

Journal article J Cataract Refract Surg · October 2001 A 56-year-old man presented with acute loss of vision and tearing in his left eye. Slitlamp examination demonstrated peripheral corneal edema extending between the 2 and 6 o'clock positions as well as a perforation located inferiorly. The right eye was unr ... Full text Link to item Cite

Long-term immunosuppressive treatment of serpiginous choroiditis.

Journal article Ocul Immunol Inflamm · September 2001 OBJECTIVE: To determine the efficacy of immunosuppressive treatment in serpiginous choroiditis. DESIGN: The clinical courses were reviewed of six consecutive patients (12 eyes) with vision-threatening, steroid-dependent/resistant serpiginous choroiditis tr ... Full text Link to item Cite

Induction of experimental autoimmune keratitis by adoptive transfer of human corneal antigen-specific T-cell line.

Journal article Invest Ophthalmol Vis Sci · December 2000 PURPOSE: To establish a permanent human corneal antigen (HuCOAg)-specific T-cell line and to determine whether line cells are capable of inducing inflammatory keratitis by adoptive transfer. METHODS: Lymphoid cells harvested from HuCOAg-immunized Lewis rat ... Link to item Cite

Mitomycin-C and vernal conjunctivitis.

Journal article Ophthalmology · December 2000 Full text Link to item Cite

Peripheral ulcerative keratitis after clear corneal cataract extraction(1).

Journal article J Cataract Refract Surg · September 2000 A previously healthy 80-year-old man had uneventful clear corneal cataract extraction. An extensive peripheral corneal infiltrate with overlying epithelial defect at the incision site was noted at the regular follow-up visit 1 week after surgery. Corneal c ... Full text Link to item Cite

Herpes zoster sine herpete presenting with hyphema.

Journal article Ocul Immunol Inflamm · June 2000 PURPOSE: To report a case of herpes zoster sine herpete presenting with hyphema. METHODS: A 69-year-old man was referred for traumatic hyphema and corneal edema in his left eye after a sandblast exposure three weeks previously. Slit-lamp examination demons ... Link to item Cite

A randomized trial of low-dose, topical mitomycin-C in the treatment of severe vernal keratoconjunctivitis.

Journal article Ophthalmology · February 2000 OBJECTIVE: To evaluate the efficacy and safety of low-dose, topical mitomycin-C in patients with severe vernal keratoconjunctivitis. DESIGN: Placebo-controlled, double-masked, randomized clinical trial. PARTICIPANTS: Twenty-six patients with vernal keratoc ... Full text Link to item Cite

Topical cyclosporin stimulates neovascularization in resolving sterile rheumatoid central corneal ulcers.

Journal article Trans Am Ophthalmol Soc · 2000 OBJECTIVE: To report the successful use of topical cyclosporin for treatment of central sterile corneal ulcers associated with rheumatoid disease. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS/INTERVENTION: Five patients (7 eyes) with col ... Link to item Cite

Bilateral consecutive central corneal perforations associated with hypogammaglobulinemia.

Journal article Ophthalmology · January 2000 OBJECTIVE: To describe the presentation and the clinical course of a patient with consecutive central sterile corneal perforations associated with common variable immunodeficiency. DESIGN: Case report. METHODS: Multiple corneal cultures and scrapings were ... Full text Link to item Cite

Choroidopathy of systemic lupus erythematosus.

Journal article Lupus · 2000 PURPOSE: To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS: Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroid ... Full text Link to item Cite

Elevated vitreous interleukin-10 level is not diagnostic of intraocular-central nervous system lymphoma.

Journal article Ophthalmology · December 1999 OBJECTIVE: Diagnosis of intraocular-central nervous system (CNS) lymphoma is commonly made by identifying malignant lymphocytes in the vitreous. However, such cells are in the minority in the vitreous cellular infiltrate (most are reactive lymphocytes), an ... Full text Link to item Cite

Krill protease effects on wound healing after corneal alkali burn.

Journal article Cornea · November 1999 PURPOSE: To study the effect of a novel protease in the development and progression of corneal ulceration secondary to alkali burning. METHODS: By using a 4N alkali burn model of corneal ulceration in rabbits, the effects and efficacy of topical applicatio ... Full text Link to item Cite

Intraocular-central nervous system lymphoma: clinical features, diagnosis, and outcomes.

Journal article Ophthalmology · September 1999 OBJECTIVE: To analyze the clinical features, laboratory investigations, and diagnosis of intraocular-central nervous system (CNS) lymphoma in a cohort of patients who underwent diagnostic vitrectomy. DESIGN: Retrospective case series. METHOD AND STUDY MATE ... Full text Link to item Cite

Ocular surface neoplasia masquerading as chronic blepharoconjunctivitis.

Journal article Cornea · May 1999 PURPOSE: To present the clinical characteristics and difficulties in the diagnosis of various ocular surface malignancies mimicking features of chronic blepharoconjunctivitis and to summarize the current therapeutic approach and prognosis of patients. METH ... Full text Link to item Cite

Conjunctival lymphoma masquerading as chronic conjunctivitis.

Journal article Ophthalmology · April 1999 OBJECTIVE: Malignant lesions of the conjunctiva may present with slowly evolving signs resembling inflammation. The authors describe the clinical and histopathologic findings of two patients with bilateral conjunctival lymphoma who presented with a history ... Full text Link to item Cite

Severity of episcleritis and systemic disease association.

Journal article Ophthalmology · April 1999 OBJECTIVE: To analyze patient characteristics and correlate between the site and severity of the inflammation and ocular and/or systemic disease association in a cohort of patients with episcleritis. DESIGN: Retrospective case series. METHODS: Medical reco ... Full text Link to item Cite

Limbal stem-cell transplantation.

Journal article Int Ophthalmol Clin · 1999 Full text Link to item Cite

Postoperative topical mitomycin C in conjunctival squamous cell neoplasia.

Journal article Cornea · January 1999 PURPOSE: To report the efficacy of topical mitomycin C in preventing local recurrences after incomplete surgical excision of conjunctival squamous cell neoplasia. METHODS: Four patients presented with unilateral conjunctival tumors. Excisional biopsy resul ... Link to item Cite

Bilateral acute retinal necrosis caused by cytomegalovirus in an immunocompromised patient.

Journal article Am J Ophthalmol · January 1999 PURPOSE: To report a case of bilateral acute retinal necrosis caused by cytomegalovirus. METHODS: A diagnostic vitrectomy was performed on a patient with non-Hodgkin lymphoma who presented with a bilateral, rapidly progressing necrotizing retinitis and uve ... Full text Link to item Cite

Ocular rosacea: patient characteristics and follow-up.

Journal article Ophthalmology · November 1997 PURPOSE: The purpose of this report is to review the presenting symptoms and signs, treatment regimens used, complications encountered, and outcome in a cohort of patients with ocular rosacea. METHODS: The medical records of 131 patients with a diagnosis o ... Link to item Cite

Invasive squamous cell carcinoma of the conjunctiva: A case report

Journal article Annals of Ophthalmology Glaucoma · December 1, 1996 This case report illustrates the clinical and histopathologic features of lymphovascular permeation by a superficially invasive squamous cell carcinoma of the conjunctiva. Cytologic study of simple conjunctival scrapings is a useful technique for confirmin ... Cite

Penetration of topical 0.3% ciprofloxacin into human aqueous humor.

Journal article Ophthalmic Surg Lasers · January 1996 BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval ... Link to item Cite