Scholars@Duke
John Matthew Falletta

John Matthew Falletta

Professor Emeritus of Pediatrics
Pediatrics, Hematology-Oncology
falle001@mc.duke.edu
2424 Erwin Rd-Suite 405, Box 2712, Durham, NC 27710
2424 Erwin Rd-Suite 405, Box 2712, Durham, NC 27710
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Selected Publications

Regulatory and ethical considerations for linking clinical and administrative databases.

Journal Article Am Heart J · June 2009 Clinical data registries are valuable tools that support evidence development, performance assessment, comparative effectiveness studies, and the adoption of new treatments into routine clinical practice. Although these registries do not have important inf ... Full text Link to item Cite

Ethical and regulatory challenges associated with the exception from informed consent requirements for emergency research: from experimental design to institutional review board approval.

Journal Article Arch Surg · October 2006 Clinical research studies conducted in emergency settings under the waiver of consent provision outlined in federal regulations are uncommon, yet the importance of such research that may result in potentially lifesaving interventions is indisputable. Surge ... Full text Link to item Cite

POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group.

Journal Article J Pediatr Hematol Oncol · June 2006 To determine if 6 courses of chemotherapy alone could achieve the same or better outcome than 4 courses of chemotherapy followed by radiation therapy (chemoradiotherapy) in pediatric and adolescent patients with Hodgkin disease. Children < or =21 years old ... Full text Link to item Cite

Influence of penicillin prophylaxis on antimicrobial resistance in nasopharyngeal S. pneumoniae among children with sickle cell anemia. The Ancillary Nasopharyngeal Culture Study of Prophylactic Penicillin Study II.

Journal Article J Pediatr Hematol Oncol · 1997 PURPOSE: To evaluate the consequences of prolonged prophylactic penicillin use on the rates of nasopharyngeal colonization with Streptococcus pneumoniae and the prevalence of resistant pneumococcal strains in children with sickle cell anemia. METHODS: Naso ... Full text Link to item Cite

Serotype-specific immunoglobulin G antibody responses to pneumococcal polysaccharide vaccine in children with sickle cell anemia: effects of continued penicillin prophylaxis.

Journal Article J Pediatr · December 1996 OBJECTIVES: (1) To determine serotype-specific IgG antibody responses to reimmunization with pneumococcal polysaccharide vaccine at age 5 years in children with sickle cell anemia and (2) to determine whether continued penicillin prophylaxis had any advers ... Full text Link to item Cite

Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II.

Journal Article J Pediatr · November 1995 OBJECTIVE: To evaluate the consequences of discontinuing penicillin prophylaxis at 5 years of age in children with sickle cell anemia who had received prophylactic penicillin for much of their lives. DESIGN: Randomized, double-blind, placebo-controlled tri ... Full text Link to item Cite

Risk factors for Wilms tumor. Report from the National Wilms Tumor Study.

Journal Article Cancer · August 1, 1993 BACKGROUND: Previous epidemiologic studies have indicated that several factors may be associated with an increased risk of Wilms tumor including paternal occupational exposures, maternal exposure during pregnancy to cigarettes, coffee or tea, oral contrace ... Full text Link to item Cite

Multiple relapses of Clostridium difficile-associated diarrhea in a cancer patient. Successful control with long-term cholestyramine therapy.

Journal Article Am J Pediatr Hematol Oncol · November 1992 Clostridium difficile-associated diarrhea (CDAD) is caused by a toxin elaborated by the anaerobic organism Clostridium difficile. Although the vast majority of CDAD cases are now associated with antibiotic use, the administration of antineoplastic agents a ... Link to item Cite

Childhood malignant non-Hodgkin lymphomas of uncommon histology.

Journal Article Leukemia · August 1992 Uncommon histologies were identified in 36 of 1336 cases (2.7%) of newly diagnosed childhood non-Hodgkin lymphoma (NHL). Seventeen cases were classified as follicular (six cases as mixed small and large cell, nine as large cell, and two as small non-cleave ... Link to item Cite

Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease.

Journal Article J Clin Epidemiol · August 1992 We have collected steady-state laboratory data for over 2600 patients, age 2 years and over, with sickle cell anemia (HbSS), HbSC disease, and HbS-beta(+)-thalassemia. The packed cell volume (PCV) is lower in males than in females until 17 or 18 years of a ... Full text Link to item Cite

Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study.

Journal Article Leukemia · June 1992 One hundred and ninety-three children with T-cell acute lymphocytic leukemia (T-ALL) whose leukemia cells were E-rosette positive were treated on a Pediatric Oncology Group study (1979-1986) designed specifically for patients with T-ALL. The results of mod ... Link to item Cite

Progress against childhood cancer: the Pediatric Oncology Group experience.

Journal Article Pediatrics · April 1992 The sequential outcome was evaluated for all childhood cancers in which the Pediatric Oncology Group has conducted a series of clinical trials, with constant eligibility, on patients with newly diagnosed cancer. The analysis was applied to more than 7000 p ... Link to item Cite

Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin: a Pediatric Oncology Group randomized phase II study.

Journal Article J Clin Oncol · February 1992 PURPOSE: The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and iproplatin in children with progressive or recurrent brain tumors. PATIENTS AND METHODS: The study was designed to evaluate the ac ... Full text Link to item Cite

Pelger-Huet anomaly in an infant with multiple congenital anomalies.

Journal Article Am J Hematol · November 1991 We report a new case of Pelger-Huet anomaly (PHA) evident from the first day of life in an infant with multiple congenital anomalies suggestive of Fryn syndrome. The infant's parents are not affected by PHA, raising the possibility that the PHA resulted fr ... Full text Link to item Cite

Nonlymphoblastic lymphoma in children--histology and stage-related response to therapy: a Pediatric Oncology Group study.

Journal Article J Clin Oncol · July 1991 From May 1979 to March 1983, 93 eligible patients with nonlymphoblastic lymphoma (NLBL) were treated by members of the Pediatric Oncology Group (POG) with Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), vincristine, prednisone, cyclophosphamide ... Full text Link to item Cite

Laboratory correlates and prognostic significance of granular acute lymphoblastic leukemia in children. A Pediatric Oncology Group study.

Journal Article Am J Clin Pathol · April 1991 As part of a comprehensive prospective clinicopathologic study by the Pediatric Oncology Group (POG), 2,092 children with acute lymphoblastic leukemia (ALL) were evaluated by uniform morphologic, cytochemical, and immunologic methods to assess the frequenc ... Full text Link to item Cite

Regulatory and ethical considerations for linking clinical and administrative databases.

Journal Article Am Heart J · June 2009 Clinical data registries are valuable tools that support evidence development, performance assessment, comparative effectiveness studies, and the adoption of new treatments into routine clinical practice. Although these registries do not have important inf ... Full text Link to item Cite

Ethical and regulatory challenges associated with the exception from informed consent requirements for emergency research: from experimental design to institutional review board approval.

Journal Article Arch Surg · October 2006 Clinical research studies conducted in emergency settings under the waiver of consent provision outlined in federal regulations are uncommon, yet the importance of such research that may result in potentially lifesaving interventions is indisputable. Surge ... Full text Link to item Cite

POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group.

Journal Article J Pediatr Hematol Oncol · June 2006 To determine if 6 courses of chemotherapy alone could achieve the same or better outcome than 4 courses of chemotherapy followed by radiation therapy (chemoradiotherapy) in pediatric and adolescent patients with Hodgkin disease. Children < or =21 years old ... Full text Link to item Cite

Influence of penicillin prophylaxis on antimicrobial resistance in nasopharyngeal S. pneumoniae among children with sickle cell anemia. The Ancillary Nasopharyngeal Culture Study of Prophylactic Penicillin Study II.

Journal Article J Pediatr Hematol Oncol · 1997 PURPOSE: To evaluate the consequences of prolonged prophylactic penicillin use on the rates of nasopharyngeal colonization with Streptococcus pneumoniae and the prevalence of resistant pneumococcal strains in children with sickle cell anemia. METHODS: Naso ... Full text Link to item Cite

Serotype-specific immunoglobulin G antibody responses to pneumococcal polysaccharide vaccine in children with sickle cell anemia: effects of continued penicillin prophylaxis.

Journal Article J Pediatr · December 1996 OBJECTIVES: (1) To determine serotype-specific IgG antibody responses to reimmunization with pneumococcal polysaccharide vaccine at age 5 years in children with sickle cell anemia and (2) to determine whether continued penicillin prophylaxis had any advers ... Full text Link to item Cite

Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II.

Journal Article J Pediatr · November 1995 OBJECTIVE: To evaluate the consequences of discontinuing penicillin prophylaxis at 5 years of age in children with sickle cell anemia who had received prophylactic penicillin for much of their lives. DESIGN: Randomized, double-blind, placebo-controlled tri ... Full text Link to item Cite

Risk factors for Wilms tumor. Report from the National Wilms Tumor Study.

Journal Article Cancer · August 1, 1993 BACKGROUND: Previous epidemiologic studies have indicated that several factors may be associated with an increased risk of Wilms tumor including paternal occupational exposures, maternal exposure during pregnancy to cigarettes, coffee or tea, oral contrace ... Full text Link to item Cite

Multiple relapses of Clostridium difficile-associated diarrhea in a cancer patient. Successful control with long-term cholestyramine therapy.

Journal Article Am J Pediatr Hematol Oncol · November 1992 Clostridium difficile-associated diarrhea (CDAD) is caused by a toxin elaborated by the anaerobic organism Clostridium difficile. Although the vast majority of CDAD cases are now associated with antibiotic use, the administration of antineoplastic agents a ... Link to item Cite

Childhood malignant non-Hodgkin lymphomas of uncommon histology.

Journal Article Leukemia · August 1992 Uncommon histologies were identified in 36 of 1336 cases (2.7%) of newly diagnosed childhood non-Hodgkin lymphoma (NHL). Seventeen cases were classified as follicular (six cases as mixed small and large cell, nine as large cell, and two as small non-cleave ... Link to item Cite

Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease.

Journal Article J Clin Epidemiol · August 1992 We have collected steady-state laboratory data for over 2600 patients, age 2 years and over, with sickle cell anemia (HbSS), HbSC disease, and HbS-beta(+)-thalassemia. The packed cell volume (PCV) is lower in males than in females until 17 or 18 years of a ... Full text Link to item Cite

Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study.

Journal Article Leukemia · June 1992 One hundred and ninety-three children with T-cell acute lymphocytic leukemia (T-ALL) whose leukemia cells were E-rosette positive were treated on a Pediatric Oncology Group study (1979-1986) designed specifically for patients with T-ALL. The results of mod ... Link to item Cite

Progress against childhood cancer: the Pediatric Oncology Group experience.

Journal Article Pediatrics · April 1992 The sequential outcome was evaluated for all childhood cancers in which the Pediatric Oncology Group has conducted a series of clinical trials, with constant eligibility, on patients with newly diagnosed cancer. The analysis was applied to more than 7000 p ... Link to item Cite

Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin: a Pediatric Oncology Group randomized phase II study.

Journal Article J Clin Oncol · February 1992 PURPOSE: The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and iproplatin in children with progressive or recurrent brain tumors. PATIENTS AND METHODS: The study was designed to evaluate the ac ... Full text Link to item Cite

Pelger-Huet anomaly in an infant with multiple congenital anomalies.

Journal Article Am J Hematol · November 1991 We report a new case of Pelger-Huet anomaly (PHA) evident from the first day of life in an infant with multiple congenital anomalies suggestive of Fryn syndrome. The infant's parents are not affected by PHA, raising the possibility that the PHA resulted fr ... Full text Link to item Cite

Nonlymphoblastic lymphoma in children--histology and stage-related response to therapy: a Pediatric Oncology Group study.

Journal Article J Clin Oncol · July 1991 From May 1979 to March 1983, 93 eligible patients with nonlymphoblastic lymphoma (NLBL) were treated by members of the Pediatric Oncology Group (POG) with Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), vincristine, prednisone, cyclophosphamide ... Full text Link to item Cite

Laboratory correlates and prognostic significance of granular acute lymphoblastic leukemia in children. A Pediatric Oncology Group study.

Journal Article Am J Clin Pathol · April 1991 As part of a comprehensive prospective clinicopathologic study by the Pediatric Oncology Group (POG), 2,092 children with acute lymphoblastic leukemia (ALL) were evaluated by uniform morphologic, cytochemical, and immunologic methods to assess the frequenc ... Full text Link to item Cite

Wilms' tumor and paternal occupation.

Journal Article Cancer Res · June 1, 1990 A case-control study was conducted to examine the relationship between Wilms' tumor and paternal occupational exposures. The case group consisted of 200 children diagnosed as having Wilms' tumor who were registered at selected National Wilms' Tumor Study i ... Link to item Cite

Phase I evaluation of diaziquone in childhood cancer. A Pediatric Oncology Group study.

Journal Article Invest New Drugs · May 1990 We conducted a phase I clinical study of aziridinylbenzoquinone (Diaziquone, AZQ) given as a 4 hour infusion weekly X 4. Forty-five children with recurrent acute leukemia and 33 children with various advanced solid tumors participated. Severe myelosuppress ... Full text Link to item Cite

Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.

Journal Article Blood · January 1, 1990 Two hundred fifty-three children with newly diagnosed T-cell acute lymphoblastic leukemia (ALL), who were treated uniformly with modified LSA2L2 therapy, were evaluated using univariate and recursive partition analyses to define clinical or biologic featur ... Link to item Cite

Isolated thrombocytopenia in children with acute lymphoblastic leukemia: a rare event in a Pediatric Oncology Group Study.

Journal Article Pediatrics · December 1989 To determine how many children with acute lymphoblastic leukemia were initially referred to a pediatric hematologist because of isolated significant thrombocytopenia ([platelet count less than 50,000/mm3] and an otherwise normal complete blood cell count a ... Link to item Cite

Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.

Journal Article J Clin Oncol · July 1989 We conducted a phase II study of intravenous (IV) melphalan in the treatment of children with recurrent medulloblastoma and in the initial treatment of children with poor-prognosis medulloblastoma and pineoblastoma. There was one complete response (CR) and ... Full text Link to item Cite

Pulmonary septic emboli mimicking metastatic rhabdomyosarcoma.

Journal Article J Pediatr Surg · May 1989 Central venous catheters have proven to be an important aid for the care of pediatric patients with malignancies receiving chemotherapy. A rare complication of such catheters is pulmonary septic emboli. This report describes a 15-year-old white girl with r ... Full text Link to item Cite

Systemic doxorubicin and intraarterial cisplatin preoperative chemotherapy plus postoperative adjuvant chemotherapy in patients with osteosarcoma.

Journal Article Cancer · March 1, 1989 The role of adjuvant chemotherapy for osteosarcoma has been well defined. Recently, the use of preoperative chemotherapy has been further enhanced by the use of intraarterial cisplatin. The authors describe the use and results of systemic doxorubicin and i ... Full text Link to item Cite

Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.

Journal Article Neurology · January 1989 We report six patients with progressive primary tumors of the brain who had prolonged periods with stable contrast-enhancing CT lesions following initial responses to chemotherapy. Chemotherapy was discontinued after 21 to 36 months, despite the persistenc ... Full text Link to item Cite

Experience with minimal complications in implanted catheters in children.

Journal Article Am J Pediatr Hematol Oncol · 1989 Eighty-two patients, ranging in age from 11 months to 24 years, underwent the percutaneous placement of an implanted catheter in order to have improved venous access. Thirty-five patients (43%) were beginning chemotherapy for cancer, four (5%) had a chroni ... Link to item Cite

Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study.

Journal Article Blood · December 1988 The immunophenotypes of lymphoblasts from children with newly diagnosed T-cell acute lymphoid leukemia (T-ALL, n = 101) or T-cell non-Hodgkin lymphoma (T-NHL, n = 31) were analyzed to correlate stage of thymocyte differentiation with clinical features and ... Link to item Cite

Congenital Pelger-Huet anomaly in triplets.

Journal Article Am J Hematol · March 1988 Congenital Pelger-Huet anomaly is an autosomal dominant disorder characterized by incomplete nuclear segmentation of granulocytes. The morphology of these mature but hyposegmented granulocytes may be confused with that of immature granulocytes (bands), the ... Full text Link to item Cite

Leukemias and lymphomas of thymic differentiation.

Journal Article Clin Lab Med · March 1988 Neoplasms of thymic T-cell derivation include two closely related malignancies: T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma. The recognition of these tumors as distinct biologic entities dates back to the early 1970s, when ... Link to item Cite

Childhood hepatic mesenchymoma: successful treatment with surgery and multiple-agent chemotherapy.

Journal Article Med Pediatr Oncol · 1988 Malignant undifferentiated sarcoma (mesenchymoma) of the liver is a rare tumor of childhood, with fewer than 100 cases reported in the literature. The overall prognosis for patients with this malignancy is poor. In this report, two children with hepatic me ... Full text Link to item Cite

Lymphoblastic lymphoma in children--a randomized trial comparing LSA2-L2 with the A-COP+ therapeutic regimen: a Pediatric Oncology Group Study.

Journal Article J Clin Oncol · January 1988 From May 1979 to March 1983, 76 evaluable patients with lymphoblastic lymphoma (LBL) were treated by members of the Pediatric Oncology Group (POG). Forty-six children treated by the six-drug A-COP+ regimen (Adriamycin [doxorubicin; Adria Laboratories, Colu ... Full text Link to item Cite

Acute lymphoid leukemia in adolescents: clinical and biologic features predict a poor prognosis--a Pediatric Oncology Group Study.

Journal Article J Clin Oncol · January 1988 Analysis of remission induction rates for 1,768 children (1.5 to 11 years) and 425 adolescents (greater than or equal to 11 years) with acute lymphoid leukemia (ALL), and of event-free survival times for 570 children and 147 adolescents, disclosed that ado ... Full text Link to item Cite

Efficacy of intravenous gamma globulin in autoimmune-mediated pediatric blood dyscrasias.

Journal Article Am J Med · October 23, 1987 Sixteen pediatric patients diagnosed with a variety of autoimmune-mediated hematocytopenias were treated with one to 50 courses of intravenous gamma globulin (IVIG), pH 4.25, over the course of one to 30 months. Thirteen patients had immune thrombocytopeni ... Full text Link to item Cite

Treatment of platelet alloimmunization with intravenous immunoglobulin. Two case reports and review of the literature.

Journal Article Am J Med · October 23, 1987 Two pediatric patients with severe aplastic anemia, elevated antiplatelet antibody levels, refractoriness to human lymphocyte antigen-matched platelet transfusions, and sustained bleeding problems were treated with intravenous immunoglobulin (IVIG), pH 4.2 ... Full text Link to item Cite

Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia. A Pediatric Oncology Group Study.

Journal Article Cancer · June 15, 1987 The immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen (CALLA)-positive and CALLA-negative T-acute lymphoblastic leukemia (ALL) and of CALLA-positive non-T, non-B ALL (common ALL) of childhood were compared. Twenty-se ... Full text Link to item Cite

Treatment of lymphohistiocytic erythrophagocytosis with VP-16 and aziridinylbenzoquinone.

Journal Article Med Pediatr Oncol · 1987 Lymphohistiocytic erythrophagocytosis (LE) is a usually fatal disease characterized by fever, organomegaly, hyperlipidemia, central nervous system involvement, and cellular immunodeficiency. Treatment with corticosteroids, cytotoxic chemotherapy, and blood ... Full text Link to item Cite

Bacterial endocarditis in a child with a Broviac catheter.

Journal Article Pediatr Hematol Oncol · 1987 Broviac and Hickman catheters facilitate the care of children with cancer but provide a source of potential infection. We describe a child with a Broviac catheter who developed left-sided bacterial endocarditis in whom right-to-left atrial shunting was doc ... Full text Link to item Cite

Management of human immunodeficiency virus-associated thrombocytopenia with intravenous gamma globulin.

Journal Article Am J Pediatr Hematol Oncol · 1987 A 17-month-old boy in whom immune-mediated thrombocytopenia (ITP) was the presenting manifestation of infection with human immunodeficiency virus (HIV) is being successfully managed with intermittent high-dose intravenous gamma globulin (IVIG) allowing mai ... Full text Link to item Cite

Physicians as science writers.

Journal Article N C Med J · January 1987 Link to item Cite

Treatment of trilateral retinoblastoma with vincristine and cyclophosphamide.

Journal Article Am J Ophthalmol · November 15, 1986 Current therapy for patients with trilateral retinoblastoma, consisting primarily of surgical intervention and radiotherapy, has resulted in no long-term survivors. The use of adjuvant chemotherapy has not improved this outcome. After observing a tumor res ... Full text Link to item Cite

Acid phosphatase positivity in childhood acute lymphocytic leukemia.

Journal Article Am J Clin Pathol · November 1986 The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (A ... Full text Link to item Cite

Bacteremia in sickle hemoglobinopathies.

Journal Article J Pediatr · October 1986 We analyzed 178 episodes of bacteremia that occurred during 13,771 patient-years of follow-up of 3451 patients with sickle hemoglobinopathies. Age-specific incidence rates of bacteremia were calculated for patients with sickle cell anemia (SS) and sickle c ... Full text Link to item Cite

Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial.

Journal Article N Engl J Med · June 19, 1986 Children with sickle cell anemia have an increased susceptibility to bacterial infections, especially to those caused by Streptococcus pneumoniae. We therefore conducted a multicenter, randomized, double-blind, placebo-controlled clinical trial to test whe ... Full text Link to item Cite

Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.

Journal Article Cancer · April 15, 1986 This study tested the efficacy of rubidazone in the treatment of recurrent acute leukemia in children. In the first phase of this study, rubidazone was administered in a dose of 450 mg/m2 to 26 children with acute lymphocyte leukemia (ALL) and to 8 childre ... Full text Link to item Cite

9p- in a girl with acute lymphocytic leukemia and sickle cell disease.

Journal Article Cancer Genet Cytogenet · April 1, 1986 A 4 year old girl with sickle cell disease developed acute lymphocytic leukemia null cell type. The bone marrow karyotype was 46,XX,del(9)(p13). This girl is among the few patients with acute lymphocytic leukemia and abnormalities of #9 to have an isolated ... Full text Link to item Cite

Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma.

Journal Article Neurosurgery · March 1986 We conducted a Phase II study of combination therapy with vincristine and cyclophosphamide in the treatment of patients with recurrent or metastatic medulloblastoma. Fourteen patients were treated with vincristine 2 mg/m2 (2.0-mg maximal dose) by intraveno ... Full text Link to item Cite

The French-American-British (FAB) classification of leukemia. The Pediatric Oncology Group experience with lymphocytic leukemia.

Journal Article Cancer · March 1, 1986 The Pediatric Oncology Group institutions initiated extensive subclassification of cases of acute lymphocytic leukemia (ALL) at diagnosis into laboratory-designated categories. Included was a French-American-British (FAB) classification of all new patients ... Full text Link to item Cite

Clinicopathologic aspects of E rosette negative T cell acute lymphocytic leukemia: a Pediatric Oncology Group study.

Journal Article J Clin Oncol · February 1986 The Pediatric Oncology Group has studied 1,367 patients with non-B cell acute lymphocytic leukemia (ALL) of whom 186 (14%) had blasts that reacted with previously well-characterized heteroantisera, recognizing a T-lymphocyte specific surface membrane antig ... Full text Link to item Cite

Severe Mycoplasma pneumonia in three sisters with sickle cell disease.

Journal Article Pediatr Hematol Oncol · 1986 Mycoplasma pneumoniae, which usually causes mild infections in normal children, has been shown to cause isolated cases of severe pneumonia in children with sickle cell disease. We recently observed an outbreak of Mycoplasma pneumonia in three sisters with ... Full text Link to item Cite

Prognostic implications for direct platelet-associated IgG in childhood idiopathic thrombocytopenic purpura.

Journal Article Am J Pediatr Hematol Oncol · 1986 To determine the value of the direct platelet associated IgG (PAIgG) level as a prognostic indicator in childhood idiopathic thrombocytopenia purpura (ITP), 18 children with ITP were studied. Ten of the 18 had PAIgG levels measured at diagnosis, before any ... Full text Link to item Cite

Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group Study.

Journal Article Blood · January 1986 Analysis of remission induction rates for 1,117 children 18 months to 10 years of age (group 1) and 90 infants less than 18 months of age (group 2) with acute lymphoid leukemia (ALL) and of duration of continuous complete remission (CCR) for 454 in group 1 ... Link to item Cite

Pharmacokinetics of diaziquone after three different dosage regimens.

Journal Article Cancer Treat Rep · December 1985 Diaziquone (AZQ) is a benzoquinone derivative exhibiting significant effects against CNS tumors. This study investigates the pharmacokinetics of AZQ for three different durations of continuous iv infusions, over 20 mins, 4 hrs, and 6 hrs, in nine patients ... Link to item Cite

An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study.

Journal Article Cancer · October 15, 1985 The presence or absence of the Fc receptor (FcR) on bone marrow lymphoblasts was evaluated in 279 cases of acute lymphoblastic leukemia (ALL) by member institutions of the Pediatric Oncology Group (POG). The case material was classified as follows: 19 case ... Full text Link to item Cite

Infectious and bleeding complications in patients with glycogenosis Ib.

Journal Article Am J Dis Child · July 1985 Clinical, hematologic, and immunologic findings were reviewed in 21 patients with glycogenosis Ib. Fifteen of the patients suffered from moderate to severe bacterial infections. Ten patients had excessive epistaxis or bleeding from surgical sites, and eigh ... Full text Link to item Cite

Monoclonal antibody definition of T cell acute leukemia: a Pediatric Oncology Group study.

Journal Article Blood · April 1985 Leukemic blasts from 774 children with newly diagnosed acute lymphocytic leukemia (ALL) have been phenotyped by microcytotoxicity testing with a panel of monoclonal antibodies and heteroantisera as part of a Pediatric Oncology Group classification study of ... Link to item Cite

Treatment for advanced Hodgkins disease (HD) in children

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

The clinical value of qualitative peripheral blood leukocyte changes.

Journal Article Blood Cells · 1985 The assessment of qualitative leukocyte changes is rarely useful to the clinician in making a precise diagnosis of illness unless a quantitative leukocyte abnormality also exists. This may, however, soon change. Current technology, albeit in the setting of ... Link to item Cite

Predicting relapse of patients with T antigen positive acute lymphocytic leukemia (T cell ALL)

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

Treatment of patients with recurrent primary brain tumors with AZQ.

Journal Article Neurology · May 1984 We have evaluated the efficacy of intravenous 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (diaziquone or AZQ, NSC-182986) in the treatment of recurrent primary anaplastic brain tumors. Three of 16 evaluable patients (18.8%) showed clinical an ... Full text Link to item Cite

Childhood cancer and occupational radiation exposure in parents.

Journal Article Cancer · April 15, 1984 To test the hypothesis that a parent's job exposure to radiation affects his or her child's risk of cancer, the authors compared this exposure during the year before the child's birth for parents of children with and without cancer. Parents of children wit ... Full text Link to item Cite

Retinoblastoma metastatic to bone marrow. A case with florid spread.

Journal Article Clin Pediatr (Phila) · March 1984 A 28-month-old white male, 7 months status postenucleation for retinoblastoma, presented with lethargy, irritability, anemia, and thrombocytopenia. Bone marrow examination revealed almost total replacement of marrow elements with clumps of small round baso ... Full text Link to item Cite

Pediatric oncology group utilization of immunologic markers in the designation of acute lymphocytic leukemia subgroups: influence on treatment response.

Journal Article Ann N Y Acad Sci · 1984 The clinical application of blast cell immunophenotype testing is important in childhood ALL for the following reasons. (1) Knowledge of the immunologic group is important in predicting prognosis. Prognostic grouping may prove to be accomplished best by us ... Full text Link to item Cite

Propionibacterium shunt nephritis in two adolescents with medulloblastoma.

Journal Article Cancer · July 15, 1983 The anaerobic diphtheroid Propionibacterium acnes was identified as the organism responsible for "shunt" nephritis in two adolescents with ventriculoatrial shunts inserted previously for the management of medulloblastoma. Only three cases of "shunt" nephri ... Full text Link to item Cite

S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine.

Journal Article Cancer Res · July 1983 A patient with refractory T-cell acute lymphoblastic leukemia was treated with eight courses of the adenosine deaminase inhibitor, 2'-deoxycoformycin (dCF), over a 5-month period. After developing resistance to dCF, he responded to treatment with the combi ... Link to item Cite

The problem of benign pulmonary nodules in children receiving cytotoxic chemotherapy.

Journal Article AJR Am J Roentgenol · January 1983 Chest computed tomography (CT) is often used to detect and monitor pulmonary nodules in children undergoing chemotherapy for underlying sarcoma. Three children underwent resection of nodules which persisted during chemotherapy. In two children, all resecte ... Full text Link to item Cite

Modified LSA2-L2 treatment in 53 children with E-rosette-positive T-cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study).

Journal Article Blood · November 1982 In an attempt to improve the poor outlook for children with T-cell leukemia (T-ALL), the Southwest Oncology Group, Pediatric Division, used a modified LSA2-L2 multidrug regimen to treat 53 patients with E-rosette-positive T-ALL. This regimen was chosen bec ... Link to item Cite

CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study.

Journal Article Cancer · September 15, 1982 Children with acute lymphoblastic leukemia were randomized to one of two treatment options for CNS prophylaxis. All patients received intrathecal therapy over a one-year period with methotrexate, hydrocortisone and cytosine arabinoside. One-half of the pat ... Full text Link to item Cite

Environmental factors in the etiology of rhabdomyosarcoma in childhood.

Journal Article J Natl Cancer Inst · January 1982 In a case-control study of childhood rhabdomyosarcoma (RMS), families of 33 cases and 99 controls were interviewed. A relative risk (RR) of 3.9 was found associated with fathers' (but not mothers') cigarette smoking (P = 0.003). Cases had had fewer immuniz ... Link to item Cite

Southwest Oncology Group Experience with Immunological Phenotyping in Acute Lymphocytic Leukemia of Childhood

Journal Article Cancer Research · November 1, 1981 The Pediatric Division of the Southwest Oncology Group is attempting to define subgroups of acute lymphoblastic leukemia (ALL) by laboratory delineation of marrow lymphoblast characteristics at diagnosis. Immunological subclassification studies include ery ... Cite

Central nervous system leukaemia.

Journal Article Lancet · September 19, 1981 Full text Link to item Cite

Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells.

Journal Article Infect Immun · July 1981 Mice were studied for 3 to 4 months after murine cytomegalovirus (MCMV) infection. Serial hematological parameters were evaluated. It was found that MCMV infection of mice were accompanied by the appearance of many atypical lymphocytes similar to those see ... Full text Link to item Cite

An analysis of clinical and laboratory features of acute lymphocytic leukemias with emphasis on 35 children with pre-B leukemia.

Journal Article Blood · July 1981 In 35 of 191 patients with acute lymphocytic leukemia (ALL) malignant cells were similar in phenotype to B-lymphocyte precursors. Both these patients' lymphoblasts and normal pre-B-cells contain cytoplasmic immunoglobulin (Ig) mu heavy chains, but have no ... Link to item Cite

Effects of deoxyadenosine (dAdo) and adenine arabinoside (AraA) during deoxycoformycin (dCF) therapy

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1981 Cite

Comparative clinical trial of metoprolol as a single-dose versus twice-dailty dose regimen in uncomplicated hypertensive patients

Journal Article Current Therapeutic Research - Clinical and Experimental · January 1, 1981 In a single-factor study of 24 weeks' duration with time sequence of repeated measurement, the optimal therapeutic efficacy of metoprolol as a single-dose versus twice-daily dose regimens in uncomplicated hypertensive patients was compared. Thirty moderate ... Cite

Detection and partial characterization of human thymus-leukemia antigens.

Journal Article J Natl Cancer Inst · October 1980 Two monkey antisera against human thymocytes after absorption with human erythrocytes and peripheral blood leukocytes were shown to detect human thymus-leukemia (HTL)-like antigens. These sera were cytotoxic for thymocytes (> 90% lysis at a 1:10 dilution) ... Full text Link to item Cite

Cancer in children of parents exposed to hydrocarbon-related industries and occupations.

Journal Article Am J Epidemiol · March 1980 Recent animal and human studies suggest that prenatal exposure to carcinogens may increase the risk of childhood malignancy. The Texas Childhood Cancer Study (1976-1977) was designed to test the hypothesis that parental exposure to hydrocarbon-related occu ... Full text Link to item Cite

Factors effecting granulopoiesis in childhood aplastic anemia

Journal Article American Journal of Pediatric Hematology/Oncology · January 1, 1980 In this study, we investigated the factors involved in the regulation of granulopoiesis in childhood aplastic anemia. Bone marrow, peripheral blood cells, and serum from nine children with aplastic anemia were added to normal bone marrow cells. All patient ... Cite

Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study.

Journal Article Med Pediatr Oncol · 1980 This report updates experience with the CONPADRI-I, COMPADRI-II, and COMPADRI-III adjuvant chemotherapy programs for the treatment of nonmetastatic osteosarcoma. A total of 200 patients received one of the three regimens. The analysis of response to treatm ... Full text Link to item Cite

Diagnosis and management of Wilms' tumor.

Journal Article Compr Ther · June 1979 Link to item Cite

A new chemotherapeutic approach to T-cell acute lymphocyte leukemia

Journal Article Clinical Research · January 1, 1979 Cite

The implication of thermostable and thermolabile T-cell leukemia in randomized trials (Potential prognostic significance)

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1979 Cite

Current concepts. Cancer in children.

Journal Article N C Med J · November 1978 Link to item Cite

Lymphocytic leukemia in children: prognostic significance of clinical and laboratory findings at time of diagnosis.

Journal Article J Pediatr · April 1978 Forty-eight children with untreated acute lymphocytic leukemia were evaluated with regard to their clinical presentation and the surface membrane characteristics, mitogen responsiveness, and cytochemical staining features of their lymphoblasts. The presenc ... Full text Link to item Cite

Dissimilar courses of twins with leukemia.

Journal Article Med Pediatr Oncol · 1977 Twin girls, genetically identical, probably experienced different leukemogenic events and presented with acute lymphocytic leukemia 6 years apart. Their clinical presentations were similar, but they received significantly different therapy. The first twin ... Full text Link to item Cite

5-Fluorouracil in childhood solid tumors.

Journal Article Cancer Treat Rep · 1977 Link to item Cite

Cyclophosphamide-asparaginase- vincristine-prednisone induction therapy in childhood acute lymphocytic and nonlymphocytic leukemia.

Journal Article Cancer · March 1976 A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction. The more intensive regimen was associated with a lower complete re ... Full text Link to item Cite

Remission induction with L-asparaginase, vincristine, and prednisone in children with acute nonlymphoblastic leukemia.

Journal Article Med Pediatr Oncol · 1976 Forty-five children with acute nonlymphoblastic leukemia in relapse received a total of 56 courses of L-asparaginase combined with vincristine and prednisone. The complete remission rate of 40% (12 of 30 trials) in patients resistant to vincristine and pre ... Full text Link to item Cite

Amplification of concanavalin A response by human lymphocytes separable by density

Journal Article Federation Proceedings · January 1, 1976 Cite

Acute leukemia in Burkitt lymphoma.

Journal Article Med Pediatr Oncol · 1976 Burkitt lymphoma uncommonly presents as a acute leukemia. We describe the clinical course and findings of a 14-year-old female with Burkitt lymphoma who presented with acute leukemia. splenomegaly and an abdominal mass. She responded initially to prednison ... Full text Link to item Cite

Immunologic chimerism as evidence of bone marrow graft acceptance in an identical twin with acute lymphocytic leukemia.

Journal Article Exp Hematol · August 1975 Bone marrow from a well child was infused into her identical twin who had acute lymphocytic leukemia. In an attempt to provide an immunologic tag for use in twin transplantation, the donor twin was immunized to Keyhole limpet hemocyanin (KLH) and yellow fe ... Link to item Cite

Guanazole (NSC 1895) in the treatment of childhood leukemia

Journal Article CANCER CHEMOTHER.REP. · December 1, 1974 Twenty six children with late stage acute leukemia in relapse were treated with a total of 48 courses of guanazole at a dose of 15 g/m2/dy for 5 days, given approximately every 2 wk. No complete or partial remissions were achieved in 18 evaluable patients, ... Cite

Immunotherapy of childhood cancer

Journal Article Pediatric Annals · January 1, 1974 Most human cancers possess tumor associated antigens (TAA) which are not detectable on the patient's normal cells. Cancer immunotherapy seeks to utilize an enhanced immune response directed against these TAA to eradicate an already established malignancy. ... Cite

Leukemia in twins.

Journal Article Pediatrics · December 1973 Link to item Cite

Letter: Incidence of childhood leukaemia.

Journal Article Lancet · October 13, 1973 Full text Link to item Cite

Ig-positive lymphocytes in Hodgkin's disease.

Journal Article N Engl J Med · March 15, 1973 Link to item Cite