Fan Wang | Scholars@Duke

Fan Wang
Morris N. Broad Distinguished Professor

My lab studies neural circuit basis of sensory perception.
Specifically we are interested in determining neural circuits underlying (1) active touch sensation including tactile processing stream and motor control of touch sensors on the face; (2) pain sensation including both sensory-discriminative and affective aspects of pain; and (3) general anesthesia including the active pain-suppression process. We use a combination of genetic, viral, electrophysiology, and in vivo imaging (in free-moving animals) techniques to study these questions.

Current Appointments & Affiliations

Morris N. Broad Distinguished Professor, Neurobiology, Basic Science Departments 2018
Professor of Neurobiology, Neurobiology, Basic Science Departments 2017
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

Box 3209, Durham, NC 27710
Bryan Research Building, 311 Research Drive Room 301E, Durham, NC 27710
fan.wang@duke.edu (919) 684-3682

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Stanford University 1998 - 2003
- Ph.D., Columbia University 1998
Duke Appointment History
- Professor in Cell Biology, Cell Biology, Basic Science Departments 2017 - 2018
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2013 - 2017
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2013 - 2017
- Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2004 - 2013
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2010 - 2013
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2003 - 2010
Recognition
In the News
- JUN 14, 2019
  
  Small Cluster of Neurons is Off-On Switch for Mouse Songs
- APR 18, 2019
  
  General Anesthesia Hijacks Sleep Circuitry to Knock You Out
- AUG 9, 2016
  
  Duke Brain Researchers Receive Award From Keck Foundation
- MAR 30, 2016
  
  Fan Wang wins Brain Research Foundation award
- JAN 6, 2015
  
  Researchers Map Direct Gut-Brain Connection
- NOV 24, 2014
  
  Five Faculty Named Fellows of American Association for the Advancement of Science
- JUN 3, 2014
  
  Complex Neural Circuitry Keeps You From Biting Your Tongue
- OCT 16, 2013
  
  Glowing Neurons Reveal Networked Link Between Brain, Whiskers
Awards & Honors
- AAAS Fellow. American Association for the Advancement of Science. 2014
- Sloan Research Fellowship-Neuroscience. Alfred P. Sloan Foundation. 2004
Research
Selected Grants
- NGF recruits nerve fibers to reprogram an immunosuppressive microenvironment in melanoma awarded by National Institutes of Health 2020 - 2025
- Identification and Validation of a Novel Central Analgesia Circuit awarded by National Institutes of Health 2019 - 2024
- Defining the role of peripheral Adrb3 in chronic pain and inflammation awarded by National Institutes of Health 2019 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Cortical Signature and Modulation of Pain awarded by National Institutes of Health 2018 - 2023
- Pre-motor Neural Circuits for Exploratory Movement awarded by National Institutes of Health 2013 - 2023
- Using Genetic Tools to Dissect Neural Circuits for Social Communication awarded by National Institutes of Health 2018 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Separate channels of tactile information in the somatosensory system 2016 - 2020
- A method for anterograde trans-synaptic tracing awarded by University of Southern California 2018 - 2020
- The Role of Premotor Corollary Discharge in the Insular Cortex for Pain Relief during Chronic Pain 2019 - 2020
- Unraveling the neural gate to consciousness awarded by W.M. Keck Foundation 2016 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Reverse engineering the brain stem circuits that govern exploratory behavior 2018 - 2020
- A novel paradigm to dissect the function connectivity in Shank3 autism model awarded by National Institutes of Health 2017 - 2019
- Gut-Brain Neurocircuit Modulating Eating Behavior awarded by National Institutes of Health 2015 - 2019
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by Yale University 2019
- Taking DISCO Live: Dual pathway Imaging of Striatal Circuit Output in vivo awarded by National Institutes of Health 2017 - 2019
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by National Institutes of Health 2019
- Identifying neurons and circuits mediating anesthesia-induced unconsciousness 2018 - 2019
- Toward causal neuroscience: capture and manipulate emergent neuronal ensembles awarded by National Institutes of Health 2013 - 2019
- Functions of distinct trigeminal brainstem projection pathways in tactile behavior awarded by National Institutes of Health 2017 - 2019
- Unravel the Neuronal Pathways Underlying Anesthesia-Induced Loss of Consciousness 2016 - 2018
- Understanding Sleep Disturbance in Alzheimer's Disease 2017 - 2018
- Generating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species Applicability 2015 - 2018
- Functional Characterization of Parabrachial Circuits Processing Noxious Thermal Pain awarded by National Institutes of Health 2015 - 2018
- Determining Functions of a Brainstem Pre-motor Module In Masticatory Jaw Movement awarded by National Institutes of Health 2013 - 2016
- Control of trigeminal touch sensory circuit assembly awarded by National Institutes of Health 2009 - 2016
- Genetically encoded anatomical probes for neuronal activity and plasticity awarded by National Institutes of Health 2009 - 2014
- Trigeminal mechanisms underlie distinct orofacial pain awarded by National Institutes of Health 2005 - 2011
- The Role of transcription factor Sox2 in the homeostasis of the adult esophagus awarded by National Institutes of Health 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Tschida, Katherine, Valerie Michael, Jun Takatoh, Bao-Xia Han, Shengli Zhao, Katsuyasu Sakurai, Richard Mooney, and Fan Wang. “A Specialized Neural Circuit Gates Social Vocalizations in the Mouse.” Neuron 103, no. 3 (August 7, 2019): 459-472.e4. https://doi.org/10.1016/j.neuron.2019.05.025.
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  - Jiang-Xie, Li-Feng, Luping Yin, Shengli Zhao, Vincent Prevosto, Bao-Xia Han, Kafui Dzirasa, and Fan Wang. “A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep.” Neuron 102, no. 5 (June 5, 2019): 1053-1065.e4. https://doi.org/10.1016/j.neuron.2019.03.033.
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  - Lu, Jinghao, Chunyuan Li, Jonnathan Singh-Alvarado, Zhe Charles Zhou, Flavio Fröhlich, Richard Mooney, and Fan Wang. “MIN1PIPE: A Miniscope 1-Photon-Based Calcium Imaging Signal Extraction Pipeline.” Cell Rep 23, no. 12 (June 19, 2018): 3673–84. https://doi.org/10.1016/j.celrep.2018.05.062.
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  - Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “Publisher Correction: A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 21, no. 6 (June 2018): 896. https://doi.org/10.1038/s41593-018-0103-7.
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  - McElvain, Lauren E., Beth Friedman, Harvey J. Karten, Karel Svoboda, Fan Wang, Martin Deschênes, and David Kleinfeld. “Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions.” Neuroscience 368 (January 1, 2018): 152–70. https://doi.org/10.1016/j.neuroscience.2017.08.034.
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  - Takatoh, Jun, Vincent Prevosto, and Fan Wang. “Vibrissa sensory neurons: Linking distinct morphology to specific physiology and function.” Neuroscience 368 (January 1, 2018): 109–14. https://doi.org/10.1016/j.neuroscience.2017.06.033.
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  - Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 20, no. 12 (December 2017): 1734–43. https://doi.org/10.1038/s41593-017-0012-1.
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  - Strege, Peter R., Kaitlyn Knutson, Samuel J. Eggers, Joyce H. Li, Fan Wang, David Linden, Joseph H. Szurszewski, et al. “Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release.” Sci Rep 7, no. 1 (November 15, 2017): 15650. https://doi.org/10.1038/s41598-017-15834-3.
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  - Bellavance, Marie-Andrée, Jun Takatoh, Jinghao Lu, Maxime Demers, David Kleinfeld, Fan Wang, and Martin Deschênes. “Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.” Neuron 95, no. 3 (August 2, 2017): 673-682.e4. https://doi.org/10.1016/j.neuron.2017.06.045.
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  - Bellavance, Marie-Andrée, Jun Takatoh, Jinghao Lu, Maxime Demers, David Kleinfeld, Fan Wang, and Martin Deschênes. “Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.” Neuron 95, no. 3 (August 2, 2017): 722–23. https://doi.org/10.1016/j.neuron.2017.07.022.
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  - Wang, Fan, Kaitlyn Knutson, Constanza Alcaino, David R. Linden, Simon J. Gibbons, Purna Kashyap, Madhusudan Grover, et al. “Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.” J Physiol 595, no. 1 (January 1, 2017): 79–91. https://doi.org/10.1113/JP272718.
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  - Sakurai, Katsuyasu, Shengli Zhao, Jun Takatoh, Erica Rodriguez, Jinghao Lu, Andrew D. Leavitt, Min Fu, Bao-Xia Han, and Fan Wang. “Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit.” Neuron 92, no. 4 (November 23, 2016): 739–53. https://doi.org/10.1016/j.neuron.2016.10.015.
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  - Stanek, Edward, Erica Rodriguez, Shengli Zhao, Bao-Xia Han, and Fan Wang. “Supratrigeminal Bilaterally Projecting Neurons Maintain Basal Tone and Enable Bilateral Phasic Activation of Jaw-Closing Muscles.” J Neurosci 36, no. 29 (July 20, 2016): 7663–75. https://doi.org/10.1523/JNEUROSCI.0839-16.2016.
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  - Wang, Xiaoming, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, et al. “Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.” Nat Commun 7 (May 10, 2016): 11459. https://doi.org/10.1038/ncomms11459.
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  - Deschênes, Martin, Jun Takatoh, Anastasia Kurnikova, Jeffrey D. Moore, Maxime Demers, Michael Elbaz, Takahiro Furuta, Fan Wang, and David Kleinfeld. “Inhibition, Not Excitation, Drives Rhythmic Whisking.” Neuron 90, no. 2 (April 20, 2016): 374–87. https://doi.org/10.1016/j.neuron.2016.03.007.
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  - Xu, Zhen-Zhong, Yong Ho Kim, Sangsu Bang, Yi Zhang, Temugin Berta, Fan Wang, Seog Bae Oh, and Ru-Rong Ji. “Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.” Nat Med 21, no. 11 (November 2015): 1326–31. https://doi.org/10.1038/nm.3978.
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  - Zhang, Yi, Shengli Zhao, Erica Rodriguez, Jun Takatoh, Bao-Xia Han, Xiang Zhou, and Fan Wang. “Identifying local and descending inputs for primary sensory neurons.” J Clin Invest 125, no. 10 (October 1, 2015): 3782–94. https://doi.org/10.1172/JCI81156.
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  - Kim, Il Hwan, Mark A. Rossi, Dipendra K. Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, et al. “Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.” Nat Neurosci 18, no. 6 (June 2015): 883–91. https://doi.org/10.1038/nn.4015.
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  - Matthews, David W., Martin Deschênes, Takahiro Furuta, Jeffrey D. Moore, Fan Wang, Harvey J. Karten, and David Kleinfeld. “Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking.” J Comp Neurol 523, no. 6 (April 15, 2015): 921–42. https://doi.org/10.1002/cne.23724.
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  - Zhang, Yi, Yong Chen, Wolfgang Liedtke, and Fan Wang. “Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.” Mol Pain 11 (April 10, 2015): 18. https://doi.org/10.1186/s12990-015-0017-2.
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  - Bohórquez, Diego V., Rafiq A. Shahid, Alan Erdmann, Alex M. Kreger, Yu Wang, Nicole Calakos, Fan Wang, and Rodger A. Liddle. “Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.” J Clin Invest 125, no. 2 (February 2015): 782–86. https://doi.org/10.1172/JCI78361.
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  - Bráz, João M., Fan Wang, and Allan I. Basbaum. “Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection.” Plos One 10, no. 10 (2015): e0140681. https://doi.org/10.1371/journal.pone.0140681.
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  - Chen, Yong, Patrick Kanju, Quan Fang, Suk Hee Lee, Puja K. Parekh, Whasil Lee, Carlene Moore, et al. “TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.” Pain 155, no. 12 (December 2014): 2662–72. https://doi.org/10.1016/j.pain.2014.09.033.
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  - Neufeld, Stanley J., Fan Wang, and John Cobb. “Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.” Genetics 198, no. 3 (November 2014): 1117–26. https://doi.org/10.1534/genetics.114.167460.
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  - Halassa, Michael M., Zhe Chen, Ralf D. Wimmer, Philip M. Brunetti, Shengli Zhao, Basilis Zikopoulos, Fan Wang, Emery N. Brown, and Matthew A. Wilson. “State-dependent architecture of thalamic reticular subnetworks.” Cell 158, no. 4 (August 14, 2014): 808–21. https://doi.org/10.1016/j.cell.2014.06.025.
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  - Moore, Jeffrey D., David Kleinfeld, and Fan Wang. “How the brainstem controls orofacial behaviors comprised of rhythmic actions.” Trends Neurosci 37, no. 7 (July 2014): 370–80. https://doi.org/10.1016/j.tins.2014.05.001.
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  - Kleinfeld, David, Martin Deschênes, Fan Wang, and Jeffrey D. Moore. “More than a rhythm of life: breathing as a binder of orofacial sensation.” Nat Neurosci 17, no. 5 (May 2014): 647–51. https://doi.org/10.1038/nn.3693.
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  - Stanek, Edward, Steven Cheng, Jun Takatoh, Bao-Xia Han, and Fan Wang. “Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination.” Elife 3 (April 30, 2014): e02511. https://doi.org/10.7554/eLife.02511.
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  - Kleinfeld, David, Jeffrey D. Moore, Fan Wang, and Martin Deschênes. “The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions.” Cold Spring Harb Symp Quant Biol 79 (2014): 29–39. https://doi.org/10.1101/sqb.2014.79.024794.
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  - Sakurai, Katsuyasu, Masahiro Akiyama, Bin Cai, Alexandra Scott, Bao-Xia Han, Jun Takatoh, Markus Sigrist, Silvia Arber, and Fan Wang. “The organization of submodality-specific touch afferent inputs in the vibrissa column.” Cell Rep 5, no. 1 (October 17, 2013): 87–98. https://doi.org/10.1016/j.celrep.2013.08.051.
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  - Nelson, Anders, David M. Schneider, Jun Takatoh, Katsuyasu Sakurai, Fan Wang, and Richard Mooney. “A circuit for motor cortical modulation of auditory cortical activity.” J Neurosci 33, no. 36 (September 4, 2013): 14342–53. https://doi.org/10.1523/JNEUROSCI.2275-13.2013.
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  - Wang, F., and Z. He. “Axon Maintenance and Degeneration,” August 29, 2013, 177–89. https://doi.org/10.1016/B978-0-12-397266-8.00126-5.
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  - Pagadala, Promila, Chul-Kyu Park, Sangsu Bang, Zheng-Zhong Xu, Rou-Gang Xie, Tong Liu, Bao-Xia Han, W Daniel Tracey, Fan Wang, and Ru-Rong Ji. “Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels.” J Neurosci 33, no. 33 (August 14, 2013): 13425–30. https://doi.org/10.1523/JNEUROSCI.0454-13.2013.
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  - Chen, Yong, Susan H. Williams, Amy L. McNulty, Ji Hee Hong, Suk Hee Lee, Nicole E. Rothfusz, Puja K. Parekh, et al. “Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.” Pain 154, no. 8 (August 2013): 1295–1304. https://doi.org/10.1016/j.pain.2013.04.004.
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  - Takatoh, Jun, Anders Nelson, Xiang Zhou, M McLean Bolton, Michael D. Ehlers, Benjamin R. Arenkiel, Richard Mooney, and Fan Wang. “New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking.” Neuron 77, no. 2 (January 23, 2013): 346–60. https://doi.org/10.1016/j.neuron.2012.11.010.
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  - Devereaux, Kelly, Claudia Dall’Armi, Abel Alcazar-Roman, Yuta Ogasawara, Xiang Zhou, Fan Wang, Akitsugu Yamamoto, Pietro De Camilli, and Gilbert Di Paolo. “Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.” Plos One 8, no. 10 (2013): e76405. https://doi.org/10.1371/journal.pone.0076405.
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  - Liu, Yin, Michael Rutlin, Siyi Huang, Colleen A. Barrick, Fan Wang, Kevin R. Jones, Lino Tessarollo, and David D. Ginty. “Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.” Science 338, no. 6112 (December 7, 2012): 1357–60. https://doi.org/10.1126/science.1228258.
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  - Chen, Tian Rui, Ping Wang, Liberty K. Carroll, Ying-jiu Zhang, Bao-Xia Han, and Fan Wang. “Generation and characterization of Tmeff2 mutant mice.” Biochem Biophys Res Commun 425, no. 2 (August 24, 2012): 189–94. https://doi.org/10.1016/j.bbrc.2012.07.064.
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  - Cho, Hawon, Young Duk Yang, Jesun Lee, Byeongjoon Lee, Tahnbee Kim, Yongwoo Jang, Seung Keun Back, et al. “The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.” Nat Neurosci 15, no. 7 (May 27, 2012): 1015–21. https://doi.org/10.1038/nn.3111.
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  - Minett, Michael S., Mohammed A. Nassar, Anna K. Clark, Gayle Passmore, Anthony H. Dickenson, Fan Wang, Marzia Malcangio, and John N. Wood. “Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.” Nat Commun 3 (April 24, 2012): 791. https://doi.org/10.1038/ncomms1795.
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  - Takatoh, Jun, and Fan Wang. “Axonally translated SMADs link up BDNF and retrograde BMP signaling.” Neuron 74, no. 1 (April 12, 2012): 3–5. https://doi.org/10.1016/j.neuron.2012.03.012.
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  - Klionsky, Daniel J., Fabio C. Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy 8, no. 4 (April 2012): 445–544. https://doi.org/10.4161/auto.19496.
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  - Raouf, Ramin, Francois Rugiero, Hannes Kiesewetter, Rachel Hatch, Edith Hummler, Mohammed A. Nassar, Fan Wang, and John N. Wood. “Sodium channels and mammalian sensory mechanotransduction.” Mol Pain 8 (March 26, 2012): 21. https://doi.org/10.1186/1744-8069-8-21.
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  - Raouf, R., F. Rugiero, H. Kiesewetter, R. Hatch, E. Hummler, M. A. Nassar, F. Wang, and J. N. Wood. “Sodium channels and mammalian sensory mechanotransduction.” Molecular Pain 8 (2012). https://doi.org/10.1186/1744-8069-8-21.
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  - Wang, Ping, Tianrui Chen, Katsuyasu Sakurai, Bao-Xia Han, Zhigang He, Guoping Feng, and Fan Wang. “Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution.” Sci Rep 2 (2012): 497. https://doi.org/10.1038/srep00497.
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  - Lau, Joanne, Michael S. Minett, Jing Zhao, Ulla Dennehy, Fan Wang, John N. Wood, and Yury D. Bogdanov. “Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse.” Mol Pain 7 (December 21, 2011): 100. https://doi.org/10.1186/1744-8069-7-100.
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  - McLeod, Ian X., Xiang Zhou, Qi-Jing Li, Fan Wang, and You-Wen He. “The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.” J Immunol 187, no. 10 (November 15, 2011): 5051–61. https://doi.org/10.4049/jimmunol.1100710.
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  - Leslie, Jennifer R., Fumiyasu Imai, Kaori Fukuhara, Noriko Takegahara, Tilat A. Rizvi, Roland H. Friedel, Fan Wang, Atsushi Kumanogoh, and Yutaka Yoshida. “Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.” Development 138, no. 18 (September 2011): 4085–95. https://doi.org/10.1242/dev.066076.
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  - Scott, Alexandra, Hiroshi Hasegawa, Katsuyasu Sakurai, Avraham Yaron, John Cobb, and Fan Wang. “Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.” J Neurosci 31, no. 18 (May 4, 2011): 6741–49. https://doi.org/10.1523/JNEUROSCI.5883-10.2011.
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  - Silva, Susana da, Hiroshi Hasegawa, Alexandra Scott, Xiang Zhou, Amanda K. Wagner, Bao-Xia Han, and Fan Wang. “Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.” Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3395–3400. https://doi.org/10.1073/pnas.1014411108.
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  - Silva, Susana da, and Fan Wang. “Retrograde neural circuit specification by target-derived neurotrophins and growth factors.” Curr Opin Neurobiol 21, no. 1 (February 2011): 61–67. https://doi.org/10.1016/j.conb.2010.07.007.
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  - Zhou, Xiang, Jun Takatoh, and Fan Wang. “The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.” Plos One 6, no. 1 (January 20, 2011): e16358. https://doi.org/10.1371/journal.pone.0016358.
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  - Wang, L., K. Budolfson, and F. Wang. “Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration.” Neuroscience 172 (January 13, 2011): 427–42. https://doi.org/10.1016/j.neuroscience.2010.10.035.
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  - Arenkiel, Benjamin R., Hiroshi Hasegawa, Jason J. Yi, Rylan S. Larsen, Michael L. Wallace, Benjamin D. Philpot, Fan Wang, and Michael D. Ehlers. “Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing.” Plos One 6, no. 12 (2011): e29423. https://doi.org/10.1371/journal.pone.0029423.
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  - Rodriguez, Pavel, Susana Da Silva, Leif Oxburgh, Fan Wang, Brigid L. M. Hogan, and Jianwen Que. “BMP signaling in the development of the mouse esophagus and forestomach.” Development 137, no. 24 (December 2010): 4171–76. https://doi.org/10.1242/dev.056077.
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  - Abe, Namiko, Steven H. Borson, Michael J. Gambello, Fan Wang, and Valeria Cavalli. “Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.” J Biol Chem 285, no. 36 (September 3, 2010): 28034–43. https://doi.org/10.1074/jbc.M110.125336.
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  - Zhou, Xiang, and Fan Wang. “Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.” Autophagy 6, no. 6 (August 2010): 798–99. https://doi.org/10.4161/auto.6.6.12511.
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  - Zhou, Xiang, Liangli Wang, Hiroshi Hasegawa, Priyanka Amin, Bao-Xia Han, Shinjiro Kaneko, Youwen He, and Fan Wang. “Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.” Proc Natl Acad Sci U S A 107, no. 20 (May 18, 2010): 9424–29. https://doi.org/10.1073/pnas.0914725107.
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  - Rawlins, Emma L., Tadashi Okubo, Yan Xue, David M. Brass, Richard L. Auten, Hiroshi Hasegawa, Fan Wang, and Brigid L. M. Hogan. “The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.” Cell Stem Cell 4, no. 6 (June 5, 2009): 525–34. https://doi.org/10.1016/j.stem.2009.04.002.
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  - Kessler, J. D., H. Hasegawa, S. N. Brun, B. A. Emmenegger, Z. J. Yang, J. W. Dutton, F. Wang, and R. J. Wechsler-Reya. “Erratum: N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma (Genes and Development (2009) 23 (157-170)).” Genes and Development 23, no. 4 (February 15, 2009).
  - Kessler, Jessica D., Hiroshi Hasegawa, Sonja N. Brun, Brian A. Emmenegger, Zeng-Jie Yang, John W. Dutton, Fan Wang, and Robert J. Wechsler-Reya. “N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.” Genes Dev 23, no. 2 (January 15, 2009): 157–70. https://doi.org/10.1101/gad.1759909.
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  - Sassa, Takayuki, Xiang Zhou, Bao-Xia Han, Fan Wang, and Franck Polleux. “Class III phosphatidylinositol 3-kinase (Vps34) is essential for radial neuronal migration in the developing neocortex.” Neuroscience Research 65 (January 2009): S46–S46. https://doi.org/10.1016/j.neures.2009.09.074.
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  - Wang, F. “Axon Guidance: Building Pathways with Molecular Cues in Vertebrate Sensory Systems,” January 1, 2009, 1073–79. https://doi.org/10.1016/B978-008045046-9.00338-7.
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  - Hasegawa, Hiroshi, and Fan Wang. “Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice.” J Comp Neurol 511, no. 4 (December 1, 2008): 543–56. https://doi.org/10.1002/cne.21862.
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  - Que, Jianwen, Bettina Wilm, Hiroshi Hasegawa, Fan Wang, David Bader, and Brigid L. M. Hogan. “Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development.” Proc Natl Acad Sci U S A 105, no. 43 (October 28, 2008): 16626–30. https://doi.org/10.1073/pnas.0808649105.
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  - Hasegawa, Hiroshi, Sara Abbott, Bao-Xia Han, Yi Qi, and Fan Wang. “Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene.” Neuroscience Research 61 (January 1, 2008): S181–S181.
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  - Hasegawa, Hiroshi, Sara Abbott, Bao-Xia Han, Yi Qi, and Fan Wang. “Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene.” J Neurosci 27, no. 52 (December 26, 2007): 14404–14. https://doi.org/10.1523/JNEUROSCI.4908-07.2007.
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  - Hodge, Liberty K., Matthew P. Klassen, Bao-Xia Han, Glenn Yiu, Joanna Hurrell, Audrey Howell, Guy Rousseau, Frederic Lemaigre, Marc Tessier-Lavigne, and Fan Wang. “Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.” Neuron 55, no. 4 (August 16, 2007): 572–86. https://doi.org/10.1016/j.neuron.2007.07.010.
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  - Zhou, Xiang, J Ramesh Babu, Susana da Silva, Qing Shu, Isabella A. Graef, Tim Oliver, Toshifumi Tomoda, Tomomi Tani, Marie W. Wooten, and Fan Wang. “Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.” Proc Natl Acad Sci U S A 104, no. 14 (April 3, 2007): 5842–47. https://doi.org/10.1073/pnas.0701402104.
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  - Graef, I. A., G. R. Crabtree, and F. Wang. “Calcineurin/NFAT Signaling in Development and Function of the Nervous System,” May 22, 2006, 353–78. https://doi.org/10.1002/3527608036.ch17.
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  - Grieshammer, Uta, Uta Le Ma, Andrew S. Plump, Fan Wang, Marc Tessier-Lavigne, and Gail R. Martin. “SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.” Dev Cell 6, no. 5 (May 2004): 709–17. https://doi.org/10.1016/s1534-5807(04)00108-x.
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  - Graef, Isabella A., Fan Wang, Frederic Charron, Lei Chen, Joel Neilson, Marc Tessier-Lavigne, and Gerald R. Crabtree. “Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.” Cell 113, no. 5 (May 30, 2003): 657–70. https://doi.org/10.1016/s0092-8674(03)00390-8.
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  - Lin, D. M., F. Wang, G. Lowe, G. H. Gold, R. Axel, J. Ngai, and L. Brunet. “Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity.” Neuron 26, no. 1 (April 2000): 69–80. https://doi.org/10.1016/s0896-6273(00)81139-3.
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  - Bulfone, A., F. Wang, R. Hevner, S. Anderson, T. Cutforth, S. Chen, J. Meneses, R. Pedersen, R. Axel, and J. L. Rubenstein. “An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons.” Neuron 21, no. 6 (December 1998): 1273–82. https://doi.org/10.1016/s0896-6273(00)80647-9.
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  - Wang, F., A. Nemes, M. Mendelsohn, and R. Axel. “Odorant receptors govern the formation of a precise topographic map.” Cell 93, no. 1 (April 3, 1998): 47–60. https://doi.org/10.1016/s0092-8674(00)81145-9.
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  - Mombaerts, P., F. Wang, C. Dulac, S. K. Chao, A. Nemes, M. Mendelsohn, J. Edmondson, and R. Axel. “Visualizing an olfactory sensory map.” Cell 87, no. 4 (November 15, 1996): 675–86. https://doi.org/10.1016/s0092-8674(00)81387-2.
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  - Rodriguez, Erica, David Ryu, Shengli Zhao, Bao-Xia Han, and Fan Wang. “Identifying Parabrachial Neurons Selectively Regulating Satiety for Highly Palatable Food in Mice.” Eneuro 6, no. 6 (n.d.). https://doi.org/10.1523/ENEURO.0252-19.2019.
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