Scholars@Duke
Fang-Fang Yin

Fang-Fang Yin

Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Radiation Oncology
fangfang.yin@duke.edu
Box 3295 DUMC, Durham, NC 27710
Radiation Physics, Durham, NC 27710
Office hours call 919-6602185  

Featured Works

RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: phase 2 results.

Journal article Pract Radiat Oncol · 2014 Featured Publication PURPOSE: The phase 2 component of Radiation Therapy Oncology Group (RTOG) 0631 assessed the feasibility and safety of spine radiosurgery (SRS) for localized spine metastases in a cooperative group setting. METHODS AND MATERIALS: Patients with 1-3 spine met ... Full text Link to item Cite

Uncertainties of 4-dimensional computed tomography-based tumor motion measurement for lung stereotactic body radiation therapy.

Journal article Pract Radiat Oncol · 2014 Featured Publication PURPOSE: To evaluate how well tumor motion measured prior to treatment based on 4-dimensional computer tomography (4DCT) reflects actual tumor motion during beam-on throughout the course of treatment. METHODS AND MATERIALS: Twenty-three patients who had lu ... Full text Link to item Cite

A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2013 Featured Publication PURPOSE: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality pla ... Full text Link to item Cite

Adaptive stereotactic body radiation therapy planning for lung cancer.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2013 Featured Publication PURPOSE: To investigate the dosimetric effects of adaptive planning on lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Forty of 66 consecutive lung SBRT patients were selected for a retrospective adaptive planning study. CBCT images ... Full text Link to item Cite

Radiotherapy and radiosurgery for tumors of the central nervous system.

Journal article Surg Oncol Clin N Am · July 2013 Featured Publication In this article, the application of radiotherapy, alone and in combination with surgery and chemotherapy, in the treatment of metastases to the brain (the most common malignant brain lesion), primary malignant gliomas (the most common malignant primary bra ... Full text Link to item Cite

Spiral computed tomography phase-space source model in the BEAMnrc/EGSnrc Monte Carlo system: implementation and validation.

Journal article Phys Med Biol · April 21, 2013 Featured Publication Currently, the BEAMnrc/EGSnrc Monte Carlo (MC) system does not provide a spiral CT source model for the simulation of spiral CT scanning. We developed and validated a spiral CT phase-space source model in the BEAMnrc/EGSnrc system. The spiral phase-space s ... Full text Link to item Cite

Quality requirements for stereotactic body radiation therapy (SBRT) in multi-institutional clinical trials

Journal article Ifmbe Proceedings · April 16, 2013 Featured Publication Clinical evidence have shown SBRT to be a tolerable, efficacious, and promising non-invasive therapy. Randomized prospective studies comparing surgery vs. SBRT in early-stage lung cancer are proposed to further investigate the relative survival, quality of ... Full text Cite

Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2013 Featured Publication PURPOSE: To quantify uncertainties in delineating an internal target volume (ITV) and to understand how these uncertainties may be individually minimized for stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC). METH ... Full text Link to item Cite

A dual cone-beam CT system for image guided radiotherapy: initial performance characterization.

Journal article Med Phys · February 2013 Featured Publication PURPOSE: The purpose of this study is to evaluate the performance of a recently developed benchtop dual cone-beam computed tomography (CBCT) system with two orthogonally placed tube∕detector sets. METHODS: The benchtop dual CBCT system consists of two orth ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate.

Journal article J Appl Clin Med Phys · January 7, 2013 Featured Publication The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Open Access Link to item Cite

Implementation of remote 3-dimensional image guided radiation therapy quality assurance for radiation therapy oncology group clinical trials.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2013 Featured Publication PURPOSE: To report the process and initial experience of remote credentialing of three-dimensional (3D) image guided radiation therapy (IGRT) as part of the quality assurance (QA) of submitted data for Radiation Therapy Oncology Group (RTOG) clinical trial ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate

Journal article Journal of Applied Clinical Medical Physics · January 1, 2013 Featured Publication The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Cite

Interleaved acquisition for cross scatter avoidance in dual cone-beam CT.

Journal article Med Phys · December 2012 Featured Publication PURPOSE: Cone-beam x-ray imaging with flat panel detectors is used for target localization in image guided radiation therapy. This imaging includes cone-beam computed tomography (CBCT) and planar imaging. Use of two orthogonal x-ray systems could reduce im ... Full text Link to item Cite

Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines.

Journal article Med Phys · November 2012 Featured Publication PURPOSE: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver traditionally flattened and flattening-filter-free (FFF) beams. Although it has been widely adopted in many clinics for patient treatment, limited information is available related to ... Full text Link to item Cite

Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans.

Journal article Med Phys · November 2012 Featured Publication PURPOSE: The authors present an evidence-based approach to quantify the effects of an array of patient anatomical features of the planning target volumes (PTVs) and organs-at-risk (OARs) and their spatial relationships on the interpatient OAR dose sparing ... Full text Link to item Cite

Stereotactic body radiotherapy treatment of extracranial metastases.

Journal article Nat Rev Clin Oncol · November 2012 Featured Publication Radiotherapy is an integral treatment for patients with metastatic cancer, although it is usually reserved for palliation of pain, dyspnoea, oedema, bleeding and neurological symptoms. However, the administration of high-precision radiotherapy, termed ster ... Full text Link to item Cite

Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.

Journal article Int J Radiat Oncol Biol Phys · November 1, 2012 Featured Publication PURPOSE: To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. METHODS AND MATERIALS: Cine MV images of 20 patients acquired ... Full text Link to item Cite

Implementation of dual-energy technique for virtual monochromatic and linearly mixed CBCTs.

Journal article Med Phys · October 2012 Featured Publication PURPOSE: To implement dual-energy imaging technique for virtual monochromatic (VM) and linearly mixed (LM) cone beam CTs (CBCTs) and to demonstrate their potential applications in metal artifact reduction and contrast enhancement in image-guided radiation ... Full text Link to item Cite

Feasibility study of a synchronized-moving-grid (SMOG) system to improve image quality in cone-beam computed tomography (CBCT).

Journal article Med Phys · August 2012 Featured Publication PURPOSE: To evaluate the feasibility of a synchronized moving grid (SMOG) system to remove scatter artifacts, improve the contrast-to-noise ratio (CNR), and reduce image lag artifacts in cone-beam CT (CBCT). METHODS: The SMOG system proposed here uses a ra ... Full text Link to item Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: our 1 year experience.

Journal article J Appl Clin Med Phys · July 5, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Open Access Link to item Cite

Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.

Journal article Technol Cancer Res Treat · June 2012 Featured Publication Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the b ... Full text Link to item Cite

Target localization using scanner-acquired SPECT data.

Journal article J Appl Clin Med Phys · May 10, 2012 Featured Publication Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Open Access Link to item Cite

Dosimetric comparison of treatment plans based on free breathing, maximum, and average intensity projection CTs for lung cancer SBRT.

Journal article Med Phys · May 2012 Featured Publication PURPOSE: To determine whether there is a CT dataset may be more favorable for planning and dose calculation by comparing dosimetric characteristics between treatment plans calculated using free breathing (FB), maximum and average intensity projection (MIP ... Full text Link to item Cite

Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.

Journal article Radiother Oncol · May 2012 Featured Publication PURPOSE: To investigate (1) dosimetric differences between plans calculated using the anisotropic analytical algorithm (AAA) and pencil beam convolution (PBC) algorithm, (2) the plan quality achieved using AAA compared to PBC based on dosimetric parameters ... Full text Link to item Cite

Volumetric-modulated arc therapy: effective and efficient end-to-end patient-specific quality assurance.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To explore an effective and efficient end-to-end patient-specific quality-assurance (QA) protocol for volumetric modulated arc radiotherapy (VMAT) and to evaluate the suitability of a stationary radiotherapy QA device (two-dimensional [2D] ion cha ... Full text Link to item Cite

Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting. METHODS AND MATERIALS ... Full text Link to item Cite

Accelerating phase contrast MR angiography by simplified skipped phase encoding and edge deghosting with array coil enhancement.

Journal article Med Phys · March 2012 Featured Publication PURPOSE: The aim of this work is to investigate the feasibility of accelerating phase contrast magnetic resonance angiography (PC-MRA) by the fast imaging method of simplified skipped phase encoding and edge deghosting with array coil enhancement (S-SPEED- ... Full text Link to item Cite

A novel technique for markerless, self-sorted 4D-CBCT: feasibility study.

Journal article Med Phys · March 2012 Featured Publication PURPOSE: Four-dimensional CBCT (4D-CBCT) imaging in the treatment room can provide verification of moving targets, facilitating the potential for margin reduction and consequent dose escalation. Reconstruction of 4D-CBCT images requires correlation of resp ... Full text Link to item Cite

Lipiodol: a potential direct surrogate for cone-beam computed tomography image guidance in radiotherapy of liver tumor.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2012 Featured Publication PURPOSE: To investigate the feasibility of using lipiodol as a direct surrogate for target localization using cone-beam CT (CBCT) image guidance in radiotherapy (RT) of patients with unresectable liver tumors after transarterial chemoembolization. METHODS ... Full text Link to item Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: Our 1 year experience

Journal article Journal of Applied Clinical Medical Physics · January 1, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Cite

Target localization using scanner-acquired SPECT data

Journal article Journal of Applied Clinical Medical Physics · January 1, 2012 Featured Publication Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Cite

Development of a 4D dosimetry simulation system in radiotherapy

Journal article International Journal of Biomedical Engineering and Technology · January 1, 2012 Featured Publication 4D CT image sets are used to encode patient-organ motion and to calculate the dose delivered during each respiratory phase. The dose-per-phase is summarised to the total dose via deformable registration. The system incorporates the actual beam parameters a ... Full text Cite

Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.

Journal article J Cancer Res Ther · 2012 Featured Publication AIMS: To establish a framework to implement the 4D integrated extended cardiac torso (XCAT) digital phantom for 4D radiotherapy (RT) research. MATERIALS AND METHODS: A computer program was developed to facilitate the characterization and implementation of ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging (4D-MRI) using image-based respiratory surrogate: a feasibility study.

Journal article Med Phys · December 2011 Featured Publication PURPOSE: Four-dimensional computed tomography (4D-CT) has been widely used in radiation therapy to assess patient-specific breathing motion for determining individual safety margins. However, it has two major drawbacks: low soft-tissue contrast and an exce ... Full text Link to item Cite

Contour based respiratory motion analysis for free breathing CT.

Journal article Comput Biol Med · October 2011 Featured Publication We propose a method to quantify superior-inferior (SI) motion of a rigid target using the 3D contour from free-breathing CT (FBCT). The technique utilizes similarity between 2D contours (Jaccard Index) and a population based density function for probabilit ... Full text Link to item Cite

Radiation-induced erectile dysfunction using prostate-confined modern radiotherapy in a rat model.

Journal article J Sex Med · August 2011 Featured Publication INTRODUCTION: The mechanisms of radiation-induced erectile dysfunction (ED) are unclear, as clinical studies are limited, and previous animal models were based on wide-field irradiation, which does not model current radiotherapy (RT) techniques. AIMS: To p ... Full text Link to item Cite

Potential underestimation of the internal target volume (ITV) from free-breathing CBCT.

Journal article Med Phys · August 2011 Featured Publication PURPOSE: Localization prior to delivery of SBRT to free-breathing patients is performed by aligning the planning internal target volume (ITV) from 4DCT with an on-board free-breathing cone-beam CT (FB-CBCT) image. The FB-CBCT image is assumed to also gener ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system.

Journal article J Appl Clin Med Phys · April 4, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Open Access Link to item Cite

Crescent artifacts in cone-beam CT.

Journal article Med Phys · April 2011 Featured Publication PURPOSE: In image-guided radiation therapy, cone-beam CT has been adopted for three-dimensional target localization in the treatment room. In many of these cone-beam CT images, dark and light crescent artifacts can be seen. This study investigates potentia ... Full text Link to item Cite

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study.

Journal article Phys Med Biol · March 7, 2011 Featured Publication In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this pape ... Full text Link to item Cite

A planning quality evaluation tool for prostate adaptive IMRT based on machine learning.

Journal article Med Phys · February 2011 Featured Publication PURPOSE: To ensure plan quality for adaptive IMRT of the prostate, we developed a quantitative evaluation tool using a machine learning approach. This tool generates dose volume histograms (DVHs) of organs-at-risk (OARs) based on prior plans as a reference ... Full text Link to item Cite

Feasibility study of an intensity-modulated radiation model for the study of erectile dysfunction.

Journal article J Sex Med · February 2011 Featured Publication INTRODUCTION: Preclinical studies of radiotherapy (RT) induced erectile dysfunction (ED) have been limited by radiation toxicity when using large fields. AIM: To develop a protocol of rat prostate irradiation using techniques mimicking the current clinical ... Full text Link to item Cite

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations.

Journal article J Appl Clin Med Phys · January 19, 2011 Featured Publication Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a com ... Full text Open Access Link to item Cite

Adaptive radiation therapy: technical components and clinical applications.

Journal article Cancer J · 2011 Featured Publication In current standard radiation therapy process, patient anatomy is represented by the snapshot of computed tomographic images at the simulation for treatment planning. However, patient anatomy during the treatment course is not static, and the changes can b ... Full text Link to item Cite

Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancer.

Journal article Med Dosim · 2011 Featured Publication We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with ... Full text Link to item Cite

Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2011 Featured Publication PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system

Journal article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Cite

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations of a commercial system

Journal article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a com ... Full text Cite

Apparatus-dependent dosimetric differences in spine stereotactic body radiotherapy.

Journal article Technol Cancer Res Treat · December 2010 Featured Publication The purpose of this investigation was to study apparatus-dependent dose distribution differences specific to spine stereotactic body radiotherapy (SBRT) treatment planning. This multi-institutional study was performed evaluating an image-guided robotic rad ... Full text Link to item Cite

Regional SPECT imaging using sampling principles and multiple pinholes

Journal article IEEE Nuclear Science Symposium Conference Record · December 1, 2010 Featured Publication There may be many SPECT imaging applications in which a small region is primarily of interest. One such case is imaging in the radiation therapy treatment room, as the patient is on the treatment table in position for radiation therapy. This onboard imagin ... Full text Cite

Maximum intensity projection (MIP) imaging using slice-stacking MRIa).

Journal article Med Phys · November 2010 Featured Publication PURPOSE: To evaluate the feasibility of acquiring maximum intensity projection (MIP) images using a novel slice-stacking MRI (SS-MRI) technique. METHODS: The proposed technique employed a steady state acquisition sequence to image multiple axial slices. At ... Full text Link to item Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2010 Featured Publication PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

Direction-dependent localization errors in SPECT images.

Journal article Med Phys · September 2010 Featured Publication PURPOSE: Single photon emission computed tomography (SPECT) is being investigated for imaging inside radiation therapy treatment rooms to localize biological targets. Here, computer simulations were used to analyze locational and directional dependencies i ... Full text Link to item Cite

Effects of breathing variation on gating window internal target volume in respiratory gated radiation therapya).

Journal article Med Phys · August 2010 Featured Publication PURPOSE: To investigate the effects of breathing variation on gating window internal target volume(ITVGW) in respiratory gated radiation therapy. METHOD AND MATERIALS: Two-dimensional dynamic MRI (dMRI) of lung motion was acquired in ten volunteers and eig ... Full text Link to item Cite

Stereotactic body radiation therapy: the report of AAPM Task Group 101.

Journal article Med Phys · August 2010 Featured Publication Task Group 101 of the AAPM has prepared this report for medical physicists, clinicians, and therapists in order to outline the best practice guidelines for the external-beam radiation therapy technique referred to as stereotactic body radiation therapy (SB ... Full text Link to item Cite

Arc-modulated radiation therapy based on linear models.

Journal article Phys Med Biol · July 7, 2010 Featured Publication This paper reports an inverse arc-modulated radiation therapy planning technique based on linear models. It is implemented with a two-step procedure. First, fluence maps for 36 fixed-gantry beams are generated using a linear model-based intensity-modulated ... Full text Link to item Cite

Kilovoltage cone-beam CT: comparative dose and image quality evaluations in partial and full-angle scan protocols.

Journal article Med Phys · July 2010 Featured Publication PURPOSE: To assess imaging dose of partial and full-angle kilovoltage CBCT scan protocols and to evaluate image quality for each protocol. METHODS: The authors obtained the CT dose index (CTDI) of the kilovoltage CBCT protocols in an on-board imager by ion ... Full text Link to item Cite

Estimation of computed tomography dose index in cone beam computed tomography: MOSFET measurements and Monte Carlo simulations.

Journal article Health Phys · May 2010 Featured Publication To address the lack of accurate dose estimation method in cone beam computed tomography (CBCT), we performed point dose metal oxide semiconductor field-effect transistor (MOSFET) measurements and Monte Carlo (MC) simulations. A Varian On-Board Imager (OBI) ... Full text Link to item Cite

6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT.

Journal article Radiother Oncol · April 2010 Featured Publication PURPOSE: To investigate setup discrepancies measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for patients under treatments of stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: In this work, pha ... Full text Link to item Cite

Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication PURPOSE: Dosimetric results and treatment delivery efficiency of RapidArc plans to those of conventional intensity-modulated radiotherapy (IMRT) plans were compared using the Eclipse treatment planning system for high-risk prostate cancer. MATERIALS AND ME ... Full text Link to item Cite

Estimation of absorbed doses from paediatric cone-beam CT scans: MOSFET measurements and Monte Carlo simulations.

Journal article Radiat Prot Dosimetry · March 2010 Featured Publication The purpose of this study was to establish a dose estimation tool with Monte Carlo (MC) simulations. A 5-y-old paediatric anthropomorphic phantom was computed tomography (CT) scanned to create a voxelised phantom and used as an input for the abdominal cone ... Full text Link to item Cite

Accelerating non-contrast-enhanced MR angiography with inflow inversion recovery imaging by skipped phase encoding and edge deghosting (SPEED).

Journal article J Magn Reson Imaging · March 2010 Featured Publication PURPOSE: To accelerate non-contrast-enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) with a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED). MATERIALS AND METHODS: IFIR imaging uses a preparatory inversion pulse t ... Full text Link to item Cite

Slow gantry rotation acquisition technique for on-board four-dimensional digital tomosynthesis.

Journal article Med Phys · February 2010 Featured Publication PURPOSE: Four-dimensional cone-beam computed tomography (4D CBCT) has been investigated for motion imaging in the radiotherapy treatment room. The drawbacks of 4D CBCT are long scan times and high imaging doses. The aims of this study were to develop and i ... Full text Link to item Cite

A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.

Journal article Phys Med Biol · January 21, 2010 Featured Publication Macroaggregated albumin single-photon emission computed tomography (MAA-SPECT) provides a map of the spatial distribution of lung perfusion. Our previous work developed a methodology to use SPECT guidance to reduce the dose to the functional lung in IMRT p ... Full text Link to item Cite

Similarities between static and rotational intensity-modulated plans.

Journal article Phys Med Biol · January 7, 2010 Featured Publication The aim of this study was to explore similarities between intensity-modulated radiotherapy (IMRT) and intensity-modulated arc therapy (IMAT) techniques in the context of the number of multi-leaf collimator (MLC) segments required to achieve plan objectives ... Full text Link to item Cite

Dosimetry challenges for implementing emerging technologies.

Journal article J Phys Conf Ser · 2010 Featured Publication During the last 10 years, radiation therapy technologies have gone through major changes, mainly related introduction of sophisticated delivery and imaging techniques to improve the target localization accuracy and dose conformity. While implementation of ... Full text Link to item Cite

Radiation dose from cone beam CT in a pediatric phantom: risk estimation of cancer incidence.

Journal article AJR Am J Roentgenol · January 2010 Featured Publication OBJECTIVE: The objective of our study was to measure absorbed doses and calculate effective dose (ED) from cone beam CT (CBCT) with metal oxide semiconductor field effect transistor (MOSFET) detectors in an anthropomorphic phantom and to estimate the risk ... Full text Link to item Cite

On-line adaptive radiation therapy: feasibility and clinical study.

Journal article J Oncol · 2010 Featured Publication The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT i ... Full text Open Access Link to item Cite

Patient specific quality assurance: Transition from IMRT to IMAT

Journal article Journal of Physics Conference Series · January 1, 2010 Featured Publication The purpose of this study was to test a patient-specific quality assurance (QA) protocol for intensity-modulated arc radiotherapy (IMAT), and to evaluate the use of an intensity-modulated stationary radiotherapy QA device (2D ion chamber array). Thirty-nin ... Full text Cite

ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: comparison with kilo-voltage cone-beam CT.

Journal article Radiother Oncol · December 2009 Featured Publication BACKGROUND AND PURPOSE: To compare the residual setup errors measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for a head phantom and patients receiving intracranial non-invasive fractionated stereotactic radiot ... Full text Link to item Cite

Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2009 Featured Publication PURPOSE: This clinical study evaluates the feasibility of using volumetric arc-modulated treatment (VMAT) for spine stereotactic body radiotherapy (SBRT) to achieve highly conformal dose distributions that spare adjacent organs at risk (OAR) with reduced t ... Full text Link to item Cite

A positioning QA procedure for 2D/2D (kV/MV) and 3D/3D (CT/CBCT) image matching for radiotherapy patient setup.

Journal article J Appl Clin Med Phys · October 6, 2009 Featured Publication A positioning QA procedure for Varian's 2D/2D (kV/MV) and 3D/3D (planCT/CBCT) matching was developed. The procedure was to check: (1) the coincidence of on-board imager (OBI), portal imager (PI), and cone beam CT (CBCT)'s isocenters (digital graticules) to ... Full text Open Access Link to item Cite

Development of a neuro-fuzzy technique for automated parameter optimization of inverse treatment planning.

Journal article Radiat Oncol · September 25, 2009 Featured Publication BACKGROUND: Parameter optimization in the process of inverse treatment planning for intensity modulated radiation therapy (IMRT) is mainly conducted by human planners in order to create a plan with the desired dose distribution. To automate this tedious pr ... Full text Open Access Link to item Cite

Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment.

Journal article Phys Med Biol · September 7, 2009 Featured Publication This study investigated the integration of the Calypso real-time tracking system, based on implanted ferromagnetic transponders and a detector array, into the current process for image-guided radiation treatment (IGRT) of prostate cancer at our institution ... Full text Link to item Cite

Task Group 142 report: quality assurance of medical accelerators.

Journal article Med Phys · September 2009 Featured Publication The task group (TG) for quality assurance of medical accelerators was constituted by the American Association of Physicists in Medicine's Science Council under the direction of the Radiation Therapy Committee and the Quality Assurance and Outcome Improveme ... Full text Link to item Cite

American Society of Radiation Oncology recommendations for documenting intensity-modulated radiation therapy treatments.

Journal article Int J Radiat Oncol Biol Phys · August 1, 2009 Featured Publication Despite the widespread use of intensity-modulated radiation therapy (IMRT) for approximately a decade, a lack of adequate guidelines for documenting these treatments persists. Proper IMRT treatment documentation is necessary for accurate reconstruction of ... Full text Link to item Cite

Advances in technology for intracranial stereotactic radiosurgery.

Journal article Technol Cancer Res Treat · August 2009 Featured Publication Stereotactic radiosurgery (SRS) refers to a single radiation treatment delivering a high dose to an intra-cranial target localized in three-dimensions by CT and/or MRI imaging. Traditionally, immobilization of the patient's head has been achieved using a r ... Full text Link to item Cite

Comparison of online IGRT techniques for prostate IMRT treatment: adaptive vs repositioning correction.

Journal article Med Phys · May 2009 Featured Publication This study compares three online image guidance techniques (IGRT) for prostate IMRT treatment: bony-anatomy matching, soft-tissue matching, and online replanning. Six prostate IMRT patients were studied. Five daily CBCT scans from the first week were acqui ... Full text Link to item Cite

On-board SPECT for localizing functional targets: a simulation study.

Journal article Med Phys · May 2009 Featured Publication Single photon emission computed tomography (SPECT) was investigated for imaging on-board radiation therapy machines in order to localize functional and molecular targets. A computer-simulated female NCAT phantom was positioned supine on a flat-top treatmen ... Full text Link to item Cite

Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements.

Journal article Radiat Environ Biophys · April 2009 Featured Publication Precise positioning of source and dosimeters is essential in the experimental determination of dosimetric characteristics of brachytherapy sources. Various near-water equivalent solid phantoms have been used to achieve the necessary precision in the positi ... Full text Link to item Cite

Stereotactic body radiotherapy for lesions of the spine and paraspinal regions.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2009 Featured Publication PURPOSE: To describe our experience and clinical strategy for stereotactic body radiotherapy (SBRT) of spinal lesions. METHODS AND MATERIALS: Thirty-two patients with 33 spinal lesions underwent computed tomography-based simulation while free breathing. Gr ... Full text Link to item Cite

Tracking brachytherapy sources using emission imaging with one flat panel detector.

Journal article Med Phys · April 2009 Featured Publication This work proposes to use the radiation from brachytherapy sources to track their dwell positions in three-dimensional (3D) space. The prototype device uses a single flat panel detector and a BB tray. The BBs are arranged in a defined pattern. The shadow o ... Full text Link to item Cite

Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2009 Featured Publication PURPOSE: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). ... Full text Link to item Cite

Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2009 Featured Publication PURPOSES: To quantitatively compare two-dimensional (2D) orthogonal kV with three-dimensional (3D) cone-beam CT (CBCT) for target localization; and to assess intrafraction motion with kV images in patients undergoing stereotactic body radiotherapy (SBRT). ... Full text Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions.

Journal article Radiat Oncol · January 21, 2009 Featured Publication BACKGROUND: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors -- spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pre ... Full text Open Access Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions

Journal article Radiation Oncology · January 21, 2009 Featured Publication Background: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors - spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pres ... Full text Cite

Efficient multiple acquisitions by Skipped Phase Encoding and Edge Deghosting (SPEED) using shared spatial information.

Journal article Magn Reson Med · January 2009 Featured Publication The fast MRI method of Skipped Phase Encoding and Edge Deghosting (SPEED) is further developed to accelerate multiple acquisitions. In a single acquisition, SPEED first acquires three sparse ghosted edge maps with an undersampling factor of N/3, which are ... Full text Link to item Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2009 Featured Publication PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

A positioning QA procedure for 2D/2D (kV/MV) and 3D/3D (CT/CBCT) image matching for radiotherapy patient setup

Journal article Journal of Applied Clinical Medical Physics · January 1, 2009 Featured Publication A positioning QA procedure for Varian's 2D/2D (kV/MV) and 3D/3D (planCT/CBCT) matching was developed. The procedure was to check: (1) the coincidence of on-board imager (OBI), portal imager (PI), and cone beam CT (CBCT)'s isocenters (digital graticules) to ... Full text Cite

Analysis of image quality for real-time target tracking using simultaneous kV-MV imaging.

Journal article Med Phys · December 2008 Featured Publication Real-time tracking can provide high accuracy localization for a moving target and minimize the effect of motion. Simultaneous kV-MV imaging has been proposed as a real-time tracking technique by utilizing the existing kV on-board imager (OBI) and the MV el ... Full text Link to item Cite

Decision fusion of machine learning models to predict radiotherapyinduced lung pneumonitis

Journal article Proceedings 7th International Conference on Machine Learning and Applications Icmla 2008 · December 1, 2008 Featured Publication Combining different machine learning models (decision fusion) has been shown to be an effective method for estimating the underlying physical mechanism by allowing the models to reinforce each other when consensus exists, or, conversely, negate each other ... Full text Cite

Combining multiple models to generate consensus: application to radiation-induced pneumonitis prediction.

Journal article Med Phys · November 2008 Featured Publication The fusion of predictions from disparate models has been used in several fields to obtain a more realistic and robust estimate of the "ground truth" by allowing the models to reinforce each other when consensus exists, or, conversely, negate each other whe ... Full text Link to item Cite

Dosimetric characteristics of novalis Tx system with high definition multileaf collimator.

Journal article Med Phys · October 2008 Featured Publication A new Novalis Tx system equipped with a high definition multileaf collimator (HDMLC) recently became available to perform both image-guided radiosurgery and conventional radiotherapy. It is capable of delivering a highly conformal radiation dose with three ... Full text Link to item Cite

On-board four-dimensional digital tomosynthesis: first experimental results.

Journal article Med Phys · August 2008 Featured Publication The purpose of this study is to propose four-dimensional digital tomosynthesis (4D-DTS) for on-board analysis of motion information in three dimensions. Images of a dynamic motion phantom were reconstructed using acquisition scan angles ranging from 20 deg ... Full text Link to item Cite

A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map.

Journal article Med Phys · July 2008 Featured Publication We developed a novel digital tomosynthesis (DTS) reconstruction method using a deformation field map to optimally estimate volumetric information in DTS images. The deformation field map is solved by using prior information, a deformation model, and new pr ... Full text Link to item Cite

Evaluation of an electron Monte Carlo dose calculation algorithm for electron beam.

Journal article J Appl Clin Med Phys · June 23, 2008 Featured Publication The electron Monte Carlo (eMC) dose calculation algorithm of the Eclipse treatment planning system is based heavily upon Monte Carlo simulation of the linac head and modeling of the linac beam characteristics with minimal measurement of beam data. Commissi ... Full text Open Access Link to item Cite

[Characteristics and affecting factors of denitrifying phosphorus removal in two-sludge sequencing batch reactor].

Journal article Huan Jing Ke Xue · June 2008 Featured Publication The characteristics of denitrifying phosphorus removal in a lab-scale two-sludge anaerobic-anoxic/nitrification SBR (A2 NSBR) system were studied fed with domestic wastewater. The influence of some key operation parameters, like C/P, C/N, and HRT, were exa ... Link to item Cite

Fast reconstruction of digital tomosynthesis using on-board images.

Journal article Med Phys · May 2008 Featured Publication Digital tomosynthesis (DTS) is a method to reconstruct pseudo three-dimensional (3D) volume images from two-dimensional x-ray projections acquired over limited scan angles. Compared with cone-beam computed tomography, which is frequently used for 3D image ... Full text Link to item Cite

The application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy.

Journal article J Appl Clin Med Phys · April 16, 2008 Featured Publication In inverse planning for intensity-modulated radiation therapy (IMRT), the dose specification and related weighting factor of an objective function for involved organs is usually predefined by a single value and then iteratively optimized, subject to a set ... Full text Open Access Link to item Cite

The investigation on the location effect of external markers in respiratory-gated radiotherapy.

Journal article J Appl Clin Med Phys · April 16, 2008 Featured Publication PURPOSE: To investigate the effect of the marker placement on the correlation relationship between the motions of external markers and the internal target under different breathing patterns for several lung cancer patients. METHOD AND MATERIAL: To monitor ... Full text Open Access Link to item Cite

The impact of respiratory motion and treatment technique on stereotactic body radiation therapy for liver cancer.

Journal article Med Phys · April 2008 Featured Publication Stereotactic body radiation therapy (SBRT), which delivers a much higher fractional dose than conventional treatment in only a few fractions, is an effective treatment for liver metastases. For patients who are treated under free-breathing conditions, howe ... Full text Link to item Cite

Integration of cone-beam CT in stereotactic body radiation therapy.

Journal article Technol Cancer Res Treat · April 2008 Featured Publication This report describes the technique and initial experience using cone beam CT (CBCT) for localization of treatment targets in patients undergoing stereotactic body radiation therapy (SBRT). Patients selected for SBRT underwent 3-D or 4-D CT scans in a cust ... Full text Link to item Cite

Assessment of the residual error in soft tissue setup in patients undergoing partial breast irradiation: results of a prospective study using cone-beam computed tomography.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2008 Featured Publication PURPOSE: On-board cone-beam computed tomography (CBCT) provides soft tissue information that may improve setup accuracy in patients undergoing accelerated partial breast irradiation (APBI). We used CBCT to assess the residual error in soft tissue after two ... Full text Link to item Cite

On-line re-optimization of prostate IMRT plans for adaptive radiation therapy.

Journal article Phys Med Biol · February 7, 2008 Featured Publication For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques s ... Full text Link to item Cite

Automatic registration between reference and on-board digital tomosynthesis images for positioning verification.

Journal article Med Phys · February 2008 Featured Publication The authors developed a hybrid multiresolution rigid-body registration technique to automatically register reference digital tomosynthesis (DTS) images with on-board DTS images to guide patient positioning in radiation therapy. This hybrid registration tec ... Full text Link to item Cite

Clinical assessment and characterization of a dual tube kilovoltage X-ray localization system in the radiotherapy treatment room.

Journal article J Appl Clin Med Phys · January 13, 2008 Featured Publication INTRODUCTION: Although flat-panel based X-ray imaging has been well tested in diagnostic radiology, its use as an image-guided-radiotherapy (IGRT) system in a treatment room is new and requires systematic assessment. MATERIALS AND METHODS: BrainLab Novalis ... Full text Open Access Link to item Cite

Using patient data similarities to predict radiation pneumonitis via a self-organizing map.

Journal article Phys Med Biol · January 7, 2008 Featured Publication This work investigates the use of the self-organizing map (SOM) technique for predicting lung radiation pneumonitis (RP) risk. SOM is an effective method for projecting and visualizing high-dimensional data in a low-dimensional space (map). By projecting p ... Full text Link to item Cite

Evaluation of Image Enhancement Method on Target Registration Using Cone Beam CT in Radiation Therapy.

Journal article Clin Med Oncol · 2008 Featured Publication An intensity based six-degree image registration algorithm between cone-beam CT (CBCT) and planning CT has been developed for image-guided radiation therapy (IGRT). CT images of an anthropomorphic chest phantom were acquired using conventional CT scanner a ... Full text Link to item Cite

Use of the BrainLAB ExacTrac X-Ray 6D system in image-guided radiotherapy.

Journal article Med Dosim · 2008 Featured Publication The ExacTrac X-Ray 6D image-guided radiotherapy (IGRT) system will be described and its performance evaluated. The system is mainly an integration of 2 subsystems: (1) an infrared (IR)-based optical positioning system (ExacTrac) and (2) a radiographic kV x ... Full text Link to item Cite

Comparison of radiation doses between cone beam CT and multi detector CT: TLD measurements.

Journal article Radiat Prot Dosimetry · 2008 Featured Publication In recent years, wide beam computed tomography (CT) technique has become standard in radiation oncology whereas there is little information about radiation dose assessments for the technique. A point dose measurement method was employed to assess the radia ... Full text Link to item Cite

A phantom study on target localization accuracy using cone-beam computed tomography.

Journal article Clin Med Oncol · 2008 Featured Publication The purpose of this study is to evaluate the 3-dimensional target localization accuracy of cone-beam computed tomography (CBCT) using an on-board imager (OBI). An anthropomorphic pelvis phantom was used to simulate a range of offsets in the three translati ... Full text Link to item Cite

Response to comments by Dr. Luijik and Dr. Schippers

Journal article Medical Physics · January 1, 2008 Featured Publication Full text Cite

Evaluation of an electron Monte Carlo dose calculation algorithm for electron beams

Journal article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication The electron Monte Carlo (eMC) dose calculation algorithm of the Eclipse treatment planning system is based heavily upon Monte Carlo simulation of the linac head and modeling of the linac beam characteristics with minimal measurement of beam data. Commissi ... Full text Cite

An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization

Journal article Journal of Industrial and Management Optimization · January 1, 2008 Featured Publication Radiation therapy (RT) is a non-invasive and highly ekective treatment option for Prostate cancer. The goal is to deliver the prescription dose to the tumor (prostate) while minimizing the damages to the surrounding healthy organs namely bladder, rectum, a ... Full text Cite

Application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy

Journal article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication In inverse planning for intensity-modulated radiation therapy (IMRT), the dose specification and related weighting factor of an objective function for involved organs is usually predefined by a single value and then iteratively optimized, subject to a set ... Full text Cite

Investigation of the location effect of external markers in respiratory-gated radiotherapy

Journal article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication In 7 lung and breast cancer patients, we investigated the location effect of external markers on the correlation between the motions of external markers and of an internal target under various breathing patterns. Our department developed a tumor tracking s ... Full text Cite

Clinical assessment and characterization of a dual tube kilovoltage X-ray localization system in the radiotherapy treatment room

Journal article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication Although flat-panel kilovoltage X-ray imaging devices have been well tested for clinical use in diagnostic radiology, their use as a part of an image-guided radiation therapy (IGRT) system in a treatment room is new and requires systematic assessment. We u ... Full text Cite

The impact of advanced technologies on treatment deviations in radiation treatment delivery.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2007 Featured Publication PURPOSE: To assess the impact of new technologies on deviation rates in radiation therapy (RT). METHODS AND MATERIALS: Treatment delivery deviations in RT were prospectively monitored during a time of technology upgrade. In January 2003, our department had ... Full text Link to item Cite

Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2007 Featured Publication PURPOSE: In this study, we investigate a technique of matching internal target volumes (ITVs) in four-dimensional (4D) simulation computed tomography (CT) to the composite target volume in free-breathing on-board cone-beam (CB) CT. The technique is illustr ... Full text Link to item Cite

On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2007 Featured Publication PURPOSE: High-precision intensity-modulated radiotherapy demands high patient positioning accuracy. On-board digital tomosynthesis (DTS) provides three-dimensional (3D) image guidance for daily positioning with a lower imaging dose, faster acquisition, and ... Full text Link to item Cite

Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis.

Journal article Med Phys · October 2007 Featured Publication The purpose of this study is to build and test a support vector machine (SVM) model to predict for the occurrence of lung radiation-induced Grade 2+ pneumonitis. SVM is a sophisticated statistical technique capable of separating the two categories of patie ... Full text Link to item Cite

Accelerating reconstruction of reference digital tomosynthesis using graphics hardware.

Journal article Med Phys · October 2007 Featured Publication The successful implementation of digital tomosynthesis (DTS) for on-board image guided radiation therapy (IGRT) requires fast DTS image reconstruction. Both target and reference DTS image sets are required to support an image registration application for I ... Full text Link to item Cite

The management of imaging dose during image-guided radiotherapy: report of the AAPM Task Group 75.

Journal article Med Phys · October 2007 Featured Publication Radiographic image guidance has emerged as the new paradigm for patient positioning, target localization, and external beam alignment in radiotherapy. Although widely varied in modality and method, all radiographic guidance techniques have one thing in com ... Full text Link to item Cite

Minimizing image noise in on-board CT reconstruction using both kilovoltage and megavoltage beam projections.

Journal article Med Phys · September 2007 Featured Publication We studied a recently proposed aggregated CT reconstruction technique which combines the complementary advantages of kilovoltage (kV) and megavoltage (MV) x-ray imaging. Various phantoms were imaged to study the effects of beam orientations and geometry of ... Full text Link to item Cite

A neural network model to predict lung radiation-induced pneumonitis.

Journal article Med Phys · September 2007 Featured Publication A feed-forward neural network was investigated to predict the occurrence of lung radiation-induced Grade 2+ pneumonitis. The database consisted of 235 patients with lung cancer treated using radiotherapy, of whom 34 were diagnosed with Grade 2+ pneumonitis ... Full text Link to item Cite

Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).

Journal article Med Phys · August 2007 Featured Publication Digital tomosynthesis (DTS) is a fast, low-dose three-dimensional (3D) imaging approach which yields slice images with excellent in-plane resolution, though low plane-to-plane resolution. A stack of DTS slices can be reconstructed from a single limited-ang ... Full text Link to item Cite

Comparison of similarity measures for rigid-body CT/Dual X-ray image registrations.

Journal article Technol Cancer Res Treat · August 2007 Featured Publication A set of experiments were conducted to evaluate six similarity measures for intensity-based rigid-body 3D/2D image registration. Similarity measure is an index that measures the similarity between a digitally reconstructed radiograph (DRR) and an x-ray pla ... Full text Link to item Cite

Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2007 Featured Publication PURPOSE: To develop and test a model to predict for lung radiation-induced Grade 2+ pneumonitis. METHODS AND MATERIALS: The model was built from a database of 234 lung cancer patients treated with radiotherapy (RT), of whom 43 were diagnosed with pneumonit ... Full text Link to item Cite

Self-consistent tumor control probability and normal tissue complication probability models based on generalized EUDa).

Journal article Med Phys · July 2007 Featured Publication Traditional methods to compute the tumor control probability (TCP) or normal tissue complication probability (NTCP) typically require a heterogeneous radiation dose distribution to be converted into a simple uniform dose distribution with an equivalent bio ... Full text Link to item Cite

Application of circumferencial myocardial function maps of tissue Doppler in patients with acute myocardial infarction

Journal article Chinese Journal of Medical Imaging Technology · July 1, 2007 Featured Publication Objective: A circumferencial functional map (CFM) of tissue Doppler imaging (TDI) was applied in patients with coronary artery disease (CAD) and the accuracy of CFM in assessment of ischemic region in patients with acute myocardial infarction (AMI) was eva ... Cite

A model for optimizing adenoviral delivery in human cancer gene therapy trials.

Journal article Hum Gene Ther · June 2007 Featured Publication Optimization of adenoviral delivery to the target volume is required for adenovirus-mediated cancer gene therapy to reach its maximal potential. The purpose of these studies was to develop a model of gene expression to improve adenovirus-mediated cancer ge ... Full text Link to item Cite

Reduction of organ motion by combined cardiac gating and respiratory gating.

Journal article Int J Radiat Oncol Biol Phys · May 1, 2007 Featured Publication PURPOSE: To investigate whether the effect of organ motion can be further reduced with the application of a cardiac gating technique, together with respiratory gating. METHODS AND MATERIALS: Axial and coronal images through the heart and liver were continu ... Full text Link to item Cite

Evaluation of an artificial intelligence guided inverse planning system: clinical case study.

Journal article Radiother Oncol · April 2007 Featured Publication PURPOSE: An artificial intelligence (AI) guided method for parameter adjustment of inverse planning was implemented on a commercial inverse treatment planning system. For evaluation purpose, four typical clinical cases were tested and the results from both ... Full text Link to item Cite

Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy.

Journal article Clin Colorectal Cancer · January 2007 Featured Publication Intensity-modulated photon radiation therapy (RT; IMRT) and proton therapy are advanced radiation technologies that permit improved conformation of radiation dose to target structures while limiting irradiation of surrounding normal tissues. Application of ... Full text Link to item Cite

Dosimetric feasibility of cone-beam CT-based treatment planning compared to CT-based treatment planning.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2006 Featured Publication PURPOSE: Cone-beam computed tomography (CBCT) images are currently used for positioning verification. However, it is yet unknown whether CBCT could be used in dose calculation for replanning in adaptive radiation therapy. This study investigates the dosime ... Full text Link to item Cite

A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung.

Journal article Int J Radiat Oncol Biol Phys · December 1, 2006 Featured Publication PURPOSE: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to divert dose away from higher-functioning lung, potentially reducing lung toxicity. We present a me ... Full text Link to item Cite

A quality assurance program for the on-board imager®.

Journal article Med Phys · November 2006 Featured Publication To develop a quality assurance (QA) program for the On-Board Imager (OBI) system and to summarize the results of these QA tests over extended periods from multiple institutions. Both the radiographic and cone-beam computed tomography (CBCT) mode of operati ... Full text Link to item Cite

The correlation evaluation of a tumor tracking system using multiple external markers.

Journal article Med Phys · November 2006 Featured Publication The purpose of this study is to evaluate the correlations between external markers and internal targets for radiation therapy of lung cancer patients. Using an infrared camera system coupled with a clinical simulator, the simultaneous motions of multiple e ... Full text Link to item Cite

Digital tomosynthesis with an on-board kilovoltage imaging device.

Journal article Int J Radiat Oncol Biol Phys · May 1, 2006 Featured Publication PURPOSE: To generate on-board digital tomosynthesis (DTS) and reference DTS images for three-dimensional image-guided radiation therapy (IGRT) as an alternative to conventional portal imaging or on-board cone-beam computed tomography (CBCT). METHODS AND MA ... Full text Link to item Cite

Postoperative radiosurgery for malignant spinal tumors.

Journal article Neurosurgery · May 2006 Featured Publication OBJECTIVE: Although, as a primary therapy, radiosurgery for spinal tumors is becoming more common in clinical practice and is associated with encouraging clinical results, we wanted to evaluate outcomes after radiosurgery in a series of postoperative patie ... Full text Link to item Cite

Physics and imaging for targeting of oligometastases.

Journal article Semin Radiat Oncol · April 2006 Featured Publication Oligometastases refer to metastases that are limited in number and location and are amenable to regional treatment. The majority of these metastases appear in the brain, lung, liver, and bone. Although the focus of interest in the past within radiation onc ... Full text Link to item Cite

A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy.

Journal article Radiother Oncol · February 2006 Featured Publication BACKGROUND AND PURPOSE: To develop and evaluate a technique and procedure of using gated-CT images in combination with PET image to determine the internal target volume (ITV), which could reduce the planning target volume (PTV) with adequate target coverag ... Full text Link to item Cite

Adaptive prediction of internal target motion using external marker motion: a technical study.

Journal article Phys Med Biol · January 7, 2006 Featured Publication An adaptive prediction approach was developed to infer internal target position by external marker positions. First, a prediction model (or adaptive neural network) is developed to infer target position from its former positions. For both internal target a ... Full text Link to item Cite

Towards four dimensional (4D) dosimetry for radiation-therapy.

Journal article J Phys Conf Ser · 2006 Featured Publication Full text Link to item Cite

A technique for on-board CT reconstruction using both kilovoltage and megavoltage beam projections for 3D treatment verification.

Journal article Med Phys · September 2005 Featured Publication The technologies with kilovoltage (kV) and megavoltage (MV) imaging in the treatment room are now available for image-guided radiation therapy to improve patient setup and target localization accuracy. However, development of strategies to efficiently and ... Full text Link to item Cite

Time delay measurement for linac based treatment delivery in synchronized respiratory gating radiotherapy.

Journal article Med Phys · May 2005 Featured Publication A time delay in a respiratory gating system could cause an unexpected phase mismatch for synchronized gating radiotherapy. This study presents a method of identifying and measuring the time delay in a gating system. Various port films were taken for a moti ... Full text Link to item Cite

Effects of x-ray and CT image enhancements on the robustness and accuracy of a rigid 3D/2D image registration.

Journal article Med Phys · April 2005 Featured Publication A rigid body three-dimensional/two-dimensional (3D/2D) registration method has been implemented using mutual information, gradient ascent, and 3D texturemap-based digitally reconstructed radiographs. Nine combinations of commonly used x-ray and computed to ... Full text Link to item Cite

Dosimetric study using different leaf-width MLCs for treatment planning of dynamic conformal arcs and intensity-modulated radiosurgery.

Journal article Med Phys · February 2005 Featured Publication This paper systematically studied the dosimetric difference between a 3 mm micro multileaf collimator (MLC), a 5 mm MLC, and a 10 mm MLC for stereotactic radiosurgery using the Brainscan treatment planning system. Thirty-four cases treated with the dynamic ... Full text Link to item Cite

Adaptive algebraic reconstruction technique.

Journal article Med Phys · December 2004 Featured Publication Algebraic reconstruction techniques (ART) are iterative procedures for reconstructing objects from their projections. It is proven that ART can be computationally efficient by carefully arranging the order in which the collected data are accessed during th ... Full text Link to item Cite

Image-guided procedures for intensity-modulated spinal radiosurgery. Technical note.

Journal article J Neurosurg · November 2004 Featured Publication Radiosurgery for brain tumors has been well established in the radiation oncology and neurosurgery fields. Radiosurgery of extracranial tumors such as those involving the spine is, however, still in the early stage because of difficulties in patient immobi ... Link to item Cite

A novel needle-based miniature x-ray generating system.

Journal article Phys Med Biol · October 21, 2004 Featured Publication The basic concept, design and performance of a novel needle-based x-ray system for medical applications are reported. The main principle of the system is based on a two-stage production of x-rays. The system comprises a conventional x-ray tube with an Ag a ... Full text Link to item Cite

Novalis radiosurgery for metastatic spine tumors.

Journal article Neurosurg Clin N Am · October 2004 Featured Publication It is logical to anticipate that the field of spinal radiosurgery will evolve in a fashion similar to that seen for intracranial radiosurgery. Given the frequency of various pathologic entities that affect the spine, including those that have proven to be ... Full text Link to item Cite

Image-guided radiosurgery of head and neck cancers.

Journal article Otolaryngol Head Neck Surg · June 2004 Featured Publication OBJECTIVES: Radiosurgery precisely delivers a single high dose or a few fractionated doses of radiation to a localized tumor via the stereotactic approach. Some head and neck sites are suitable for radiosurgery since there is minimal or no organ motion. Th ... Full text Link to item Cite

A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors.

Journal article Mol Ther · April 2004 Featured Publication This study describes a quantitative method to measure the magnitude and distribution of gene expression following local delivery of an adenoviral vector containing the human sodium iodide symporter (hNIS) reporter gene into the canine prostate. Following s ... Full text Link to item Cite

The evolving role of stereotactic radiosurgery and stereotactic radiation therapy for patients with spine tumors.

Journal article J Neurooncol · 2004 Featured Publication Traditional management strategies for patients with spinal tumors have undergone considerable changes during the last 15 years. Significant improvements in digital imaging, computer processing, and treatment planning have provided the basis for the applica ... Full text Link to item Cite

A phantom study on the positioning accuracy of the Novalis Body system.

Journal article Med Phys · December 2003 Featured Publication A phantom study was conducted to investigate inherent positioning accuracy of an image-guided patient positioning system-the Novalis Body system for three-dimensional (3-D) conformal radiotherapy. This positioning system consists of two infrared (IR) camer ... Full text Link to item Cite

AI-guided parameter optimization in inverse treatment planning.

Journal article Phys Med Biol · November 7, 2003 Featured Publication An artificial intelligence (AI)-guided inverse planning system was developed to optimize the combination of parameters in the objective function for intensity-modulated radiation therapy (IMRT). In this system, the empirical knowledge of inverse planning w ... Full text Link to item Cite

Fuzzy logic guided inverse treatment planning.

Journal article Med Phys · October 2003 Featured Publication A fuzzy logic technique was applied to optimize the weighting factors in the objective function of an inverse treatment planning system for intensity-modulated radiation therapy (IMRT). Based on this technique, the optimization of weighting factors is guid ... Full text Link to item Cite

GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.

Journal article Mol Ther · September 2003 Featured Publication With the goal of optimizing adenovirus-mediated suicide gene therapy for prostate cancer, we have developed a method based on the human sodium iodide symporter (hNIS) that allows for noninvasive monitoring of adenoviral vectors and quantification of gene e ... Full text Link to item Cite

Point dose verification for intensity modulated radiosurgery using Clarkson's method.

Journal article Med Phys · August 2003 Featured Publication In clinical radiation physics chart checking, the dose calculation results generated by computer treatment planning software are usually verified by an independent computerized monitor unit calculation routine, or by "hand calculation" using percent depth ... Full text Link to item Cite

Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis.

Journal article Cancer · April 15, 2003 Featured Publication BACKGROUND: Radiosurgery can deliver a single, large radiation dose to a localized tumor using a stereotactic approach and hence, requires accurate and precise delivery of radiation to the target. Of the extracranial organ targets, the spine is considered ... Full text Link to item Cite

A technique of intensity-modulated radiosurgery (IMRS) for spinal tumors.

Journal article Med Phys · December 2002 Featured Publication This study is to demonstrate the feasibility of spinal radiosurgery using an image-guided intensity-modulated radiosurgical (IMRS) procedure. A dedicated Novalis shaped beam surgery unit equipped with a built-in micro-multileaf collimator (mMLC) with a sin ... Full text Link to item Cite

Radiosurgical treatment for Ewing's sarcoma of the lumbar spine: case report.

Journal article Spine (Phila Pa 1976) · November 1, 2002 Featured Publication STUDY DESIGN: Case report. OBJECTIVES: The objective of this study was to document the long-term follow-up of a single case. SUMMARY OF BACKGROUND DATA: Radiosurgery is potentially a useful therapeutic option for spinal tumors. The authors present the unus ... Full text Link to item Cite

Accuracy of inhomogeneity correction in photon radiotherapy from CT scans with different settings.

Journal article Phys Med Biol · September 7, 2002 Featured Publication We report an investigation on the accuracy of inhomogeneity correction in photon radiotherapy from CT scans with different settings. Specifically, the dosimetric differences from different CT scan parameters (kV, mAs) to phantoms and from different Hounsfi ... Full text Link to item Cite

Dosimetric characteristics of Novalis shaped beam surgery unit.

Journal article Med Phys · August 2002 Featured Publication The dosimetric characteristics of a new dedicated radiosurgical treatment unit are systematically measured in terms of its percent depth dose, beam profile, and relative scatter factor. High-resolution diode detector, mini-ion-chamber detector, and convent ... Full text Link to item Cite

A three-dimensional deformable model for segmentation of human prostate from ultrasound images.

Journal article Med Phys · October 2001 Featured Publication Segmentation of human prostate from ultrasound (US) images is a crucial step in radiation therapy, especially in real-time planning for US image-guided prostate seed implant. This step is critical to determine the radioactive seed placement and to ensure t ... Full text Link to item Cite

Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2001 Featured Publication PURPOSE: Extracranial radiosurgery requires control of organ motion. The purpose of this study is to quantitatively determine the extent of liver motion in anesthetized dogs with continuous i.v. propofol infusion with or without muscle relaxants and high-f ... Full text Link to item Cite

Adaptive portal CT reconstruction: a simulation study.

Journal article Med Phys · October 2000 Featured Publication In radiotherapy, radiation treatment beams contain valuable information for patient setup verification. These beams may be used for portal CT reconstruction. However, direct use of the beam data for reconstruction may yield inadequate CT images simply beca ... Full text Link to item Cite

Optimization of inverse treatment planning using a fuzzy weight function.

Journal article Med Phys · April 2000 Featured Publication A fuzzy approach has been applied to inverse treatment planning optimization in radiation therapy. The proposed inverse-planning algorithm optimizes both the intensity-modulated beam (IMB) and the normal tissue prescription. In the IMB optimization, we dev ... Full text Link to item Cite

Soft optimization with fuzzy weight function

Journal article IEEE International Conference on Fuzzy Systems · December 1, 1999 Featured Publication We describe a new class of optimization method based on the theory of classic minimum using a fuzzy weight function. The technique is applied to the problem of normal tissue prescription optimization in conformal radiotherapy. The performance of the new al ... Cite

Treatment field shape verification using elliptic Fourier transform.

Journal article Med Phys · November 1999 Featured Publication An automated field shape correlation technique based on elliptic Fourier transform (EFT) is developed to verify the radiation treatment field in digital portal images. In this method, the edge of the treatment field is initially extracted from the portal i ... Full text Link to item Cite

Structures of yeast vesicle trafficking proteins.

Journal article Protein Sci · November 1999 Featured Publication In protein transport between organelles, interactions of v- and t-SNARE proteins are required for fusion of protein-containing vesicles with appropriate target compartments. Mammalian SNARE proteins have been observed to interact with NSF and SNAP, and yea ... Full text Link to item Cite

Two-dimensional direction-based interpolation with local centered moments

Journal article Graphical Models and Image Processing · January 1, 1999 Featured Publication Interpolation is generally needed to visualize medical images from a limited number of sliced tomographic images such as CT. In this paper, a novel gray-scale image interpolation method, for interpolating two-dimensional images accurately and efficiently, ... Full text Cite

Variation method for inverse treatment planning

Journal article Medical Physics · January 1, 1999 Featured Publication A new inverse planning method based on the theory of variation is developed for the computation of beam intensities that produce highly conformal dose distributions to the target volume that have an arbitrary complex geometry. It is shown that the objectiv ... Full text Cite

MR image-guided portal verification for brain treatment field.

Journal article Int J Radiat Oncol Biol Phys · February 1, 1998 Featured Publication PURPOSE: To investigate a method for the generation of digitally reconstructed radiographs directly from MR images (DRR-MRI) to guide a computerized portal verification procedure. METHODS AND MATERIALS: Several major steps were developed to perform an MR i ... Full text Link to item Cite

Oncologic image compression using both wavelet and masking techniques.

Journal article Med Phys · December 1997 Featured Publication A new algorithm has been developed to compress oncologic images using both wavelet transform and field masking methods. A compactly supported wavelet transform is used to decompose the original image into high- and low-frequency subband images. The region- ... Full text Link to item Cite

Two-dimensional refinement scheme of direction-based interpolation with discrete orthogonal polynomial decomposition

Journal article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1997 Featured Publication In this paper, a novel direction-based interpolation approach with discrete orthogonal polynomial decomposition is introduced. A 2D digital image is usually regarded as a sampling of an underlying 2D continuous function, which is called an image field. Whe ... Cite

Automated extraction of pelvic features in portal and simulation images

Journal article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1996 Featured Publication A new approach, a pyramid template matching as guided by a snake, is developed for the extraction of pelvic features in both portal and simulation images. Initially, the treatment field edge was extracted using a Canny edge detector. A template modeled usi ... Full text Cite

The effect of detector size to the broadening of the penumbra--a computer simulated study.

Journal article Med Phys · August 1996 Featured Publication The effect of detector size to the broadening of the measured beam penumbra has been a subject of numerous studies. Based on measured data, linear and quadratic curves have been proposed to describe the relationship between the measured penumbra width, bet ... Full text Link to item Cite

An observer study for direct comparison of clinical efficacy of electronic to film portal images.

Journal article Int J Radiat Oncol Biol Phys · July 15, 1996 Featured Publication PURPOSE: To directly compare clinical efficacy of electronic to film portal images. METHODS AND MATERIALS: An observer study was designed to compare clinical efficacy of electronic to film portal images acquired using a liquid matrix ion-chamber electronic ... Full text Link to item Cite

Portal image feature extraction by hierarchical region processing technique

Journal article Proceedings of the IEEE International Conference on Systems Man and Cybernetics · December 1, 1995 Featured Publication We describe in this paper a novel hierarchical region processing technique for the extraction of features from portal images. Feature extraction is an essential component in the computerized registration of portal images for radiation treatment verificatio ... Cite

Physical penumbra change of beam profile due to film digitization.

Journal article Med Phys · June 1995 Featured Publication Full text Link to item Cite

A technique of automating compensator design for lung inhomogeneity correction using an electron portal imaging device.

Journal article Med Phys · November 1994 Featured Publication A technique of automating compensator design for lung inhomogeneity correction using an electron portal imaging device (EPID) has been investigated. This technique utilizes exit-radiation information as detected by an EPID to determine the thickness of the ... Full text Link to item Cite

Input/output characteristics of a matrix ion-chamber electronic portal imaging device.

Journal article Med Phys · September 1994 Featured Publication The input/output characteristics of a matrix liquid ion-chamber electronic portal imaging device (EPID) are investigated to elucidate the imaging properties of EPIDs. The radiation input to the detector, represented by dose rate, and the pixel value output ... Full text Link to item Cite

Computerized detection of masses in digital mammograms: automated alignment of breast images and its effect on bilateral-subtraction technique.

Journal article Med Phys · March 1994 Featured Publication An automated technique for the alignment of right and left breast images has been developed for use in the computerized analysis of bilateral breast images. In this technique, the breast region is first identified in each digital mammogram by use of histog ... Full text Link to item Cite

Effect of case selection on the performance of computer-aided detection schemes.

Journal article Med Phys · February 1994 Featured Publication The choice of clinical cases used to train and test a computer-aided diagnosis (CAD) scheme can affect the test results (i.e., error rate). In this study, we deliberately modified the components of our testing database to study the effects of this modifica ... Full text Link to item Cite

Computerized detection of masses in digital mammograms: investigation of feature-analysis techniques.

Journal article J Digit Imaging · February 1994 Featured Publication Mammographic screening of asymptomatic women has shown effectiveness in the reduction of breast cancer mortality. We are developing a computerized scheme for the detection of mammographic masses as an aid to radiologists in mammographic screening programs. ... Full text Link to item Cite

Comparison of bilateral-subtraction and single-image processing techniques in the computerized detection of mammographic masses.

Journal article Invest Radiol · June 1993 Featured Publication RATIONALE AND OBJECTIVES: Identification of regions as possible masses on digitized screen film mammograms is an important initial step in the computerized detection of breast carcinomas. Possible masses may be initially extracted using criteria based on o ... Full text Link to item Cite

Evaluation of imaging properties of a laser film digitizer.

Journal article Phys Med Biol · January 1992 Featured Publication In this paper we provide a quantitative assessment of the basic imaging properties of a laser film digitizer. The characteristic curve of the digitizer was determined in terms of the relationship between input optical density and output pixel value. Spatia ... Full text Link to item Cite

Direct comparison of conventional and computed radiography with a dual-image recording technique.

Journal article Radiographics · March 1991 Featured Publication To compare the image quality of computed radiographic (CR) with conventional screen-film images, the authors used a dual-image recording technique. Images were simultaneously acquired with a conventional screen-film combination and a storage-phosphor imagi ... Full text Link to item Cite

Computerized detection of masses in digital mammograms: analysis of bilateral subtraction images.

Journal article Med Phys · 1991 Featured Publication A computerized scheme is being developed for the detection of masses in digital mammograms. Based on the deviation from the normal architectural symmetry of the right and left breasts, a bilateral subtraction technique is used to enhance the conspicuity of ... Full text Link to item Cite

Data compression: effect on diagnostic accuracy in digital chest radiography.

Journal article Radiology · January 1991 Featured Publication High-resolution digital images make up very large data sets that are relatively slow to transmit and expensive to store. Data compression techniques are being developed to address this problem, but significant image deterioration can occur at high compress ... Full text Link to item Cite

Comparison of imaging properties of a computed radiography system and screen-film systems.

Journal article Med Phys · 1991 Featured Publication To compare the diagnostic quality of images obtained with a computed radiography (CR) system based on storage phosphor technology with that obtained with conventional screen-film systems, a dual-image recording technique was devised. With this technique, a ... Full text Link to item Cite

Development of a 'smart' workstation for use in mammography

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 1991 Featured Publication We are developing various computer-vision schemes for the detection of masses and microcalcifications in digital mammograms (1-7). However, for the effective and efficient implementation of computer-aided diagnosis (CAD), appropriate man-machine interfaces ... Cite

Computer-vision system for the detection and characterization of masses for use in mammographic screening programs

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 1991 Featured Publication Studies have shown that early detection of breast cancer through periodic mammographic screening of asymptomatic women could reduce breast cancer mortality by 30-50%. However, screening yields a high volume of mammograms requiring interpretation. In additi ... Cite

Investigation of methods for the computerized detection and analysis of mammographic masses

Journal article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1990 Featured Publication At present, mammography is the most effective method for the early detection of breast cancer. Detection and classification of masses in mammograms are among the most important and difficult tasks performed by radiologists. Various studies have indicated t ... Cite

Evaluation of basic imaging properties of a new digital chest system

Journal article Proceedings of SPIE the International Society for Optical Engineering · July 1, 1990 Featured Publication A prototype digital chest system, which uses storage phosphor technology and has the advantages over existing computed radiography systems (CR) of compactness and immediate image display, is being evaluated in our laboratory. We evaluated the imaging prope ... Full text Cite

Measurement of the presampling modulation transfer function of film digitizers using a curve fitting technique.

Journal article Med Phys · 1990 Featured Publication A curve fitting technique combined with an angulated slit image has been developed for the measurement of the presampling modulation transfer function (MTF) of film digitizers. The noisy line spread functions (LSFs) acquired from an angulated slit image ar ... Full text Link to item Cite

Pulmonary nodules: computer-aided detection in digital chest images.

Journal article Radiographics · January 1990 Featured Publication Currently, radiologists fail to detect pulmonary nodules in up to 30% of cases with actually positive findings. Diagnoses may be missed due to camouflaging effects of anatomic background, subjective and varying decision criteria, or distractions in clinica ... Full text Link to item Cite