Journal articleCatheter Cardiovasc Interv · July 1, 2026
BACKGROUND: Pulmonary valve replacement is frequently required in adults with congenital heart disease (CHD). Comparative real-world outcomes between percutaneous transcatheter pulmonary valve implantation (TPVR) and surgical pulmonary valve replacement (S ...
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Journal articleBiomedicines · June 17, 2026
Background: Heart failure patients are frequently prescribed SGLT2 inhibitors, but the incremental real-world benefit of adding GLP-1 receptor agonists is uncertain. Methods: A retrospective propensity-matched cohort study was conducted using the TriNetX G ...
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Journal articleJ Arrhythm · June 2026
BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with substantial morbidity and mortality. Although early rhythm control has demonstrated benefit in selected trial populations, its real-world effectiveness re ...
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Journal articleJ Cardiovasc Dev Dis · May 23, 2026
BACKGROUND: Coronary artery disease (CAD) and heart failure with preserved ejection fraction (HFpEF) are major causes of morbidity and mortality. Systemic inflammation contributes to both, suggesting potential benefit from colchicine, though data in CAD-HF ...
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Journal articleCardiovasc Ultrasound · May 18, 2026
BACKGROUND: Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with a markedly increased risk of thromboembolic stroke, primarily originating from the left atrial appendage (LAA). Percutaneous left atrial appendag ...
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Journal articleBiomedicines · May 14, 2026
Background: Finerenone and sodium-glucose cotransporter-2 inhibitors provide cardiovascular and renal benefits in patients with chronic kidney disease (CKD) and heart failure (HF), but real-world comparative evidence is limited. Methods: This retrospective ...
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Journal articleBMC Cardiovasc Disord · May 6, 2026
INTRODUCTION: Right ventricular pacing (RVP) is the conventional treatment for atrioventricular (AV) block, but may cause ventricular dyssynchrony and adverse remodeling. Conduction system pacing (CSP) has emerged as a physiologic alternative. This meta-an ...
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Journal articleBMC Cardiovasc Disord · April 21, 2026
AIMS: Malnutrition is an under-recognized prognostic risk marker in patients hospitalized with heart failure (HF). We aimed to quantify the burden of documented malnutrition among HF hospitalizations in the United States and evaluate its independent associ ...
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Journal articleBMC Cardiovasc Disord · April 17, 2026
BACKGROUND: Cardiogenic shock (CS) and chronic ischemic heart disease (CIHD) remain major contributors to cardiovascular mortality in the United States. Although mortality related to ischemic disease declined in the early 2000s, recent trends suggest a res ...
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Journal articleJ Epidemiol Glob Health · March 19, 2026
BACKGROUND: Atrial fibrillation (AF) and congestive heart failure (CHF) remain major contributors to cardiovascular mortality in the United States. When accompanied by underlying ischemic heart disease (IHD), mortality risk is amplified. Although IHD morta ...
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Journal articleCatheter Cardiovasc Interv · March 2026
Ischemic heart disease is the leading global cause of death and frequently progresses to ischemic heart failure (IHF) after myocardial infarction through adverse left ventricular (LV)remodeling. Surgical LV restoration improves ventricular geometry and fun ...
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Journal articleCatheter Cardiovasc Interv · February 2026
INTRODUCTION: Current ESC/EACTS guidelines recommend standard-duration dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI). However, the subsequent transition to either extended DAPT or single antiplatelet therapy (SAPT) rem ...
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Book section · January 1, 2026
Echocardiography is an integral part of the diagnosis and management of cardiovascular disease. The use and application of artificial intelligence (AI) is a rapidly expanding field in medicine to improve consistency and reduce interobserver variability. AI ...
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Book section · January 1, 2026
Hyperpolarized 129Xe MRI/MRS is a rapid and non-invasive tool with significant potential to evaluate the causes of dyspnea. 129Xe, once inhaled, freely diffuses from the airspaces, across the interstitial barrier tissues, and into the ...
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Journal articleBaylor University Medical Center Proceedings · January 1, 2026
Background: The “July effect” has been hypothesized to worsen outcomes during annual trainee turnover in teaching hospitals. Whether this applies to catheter-directed therapies for pulmonary embolism (PE) is unknown. Methods: We analyzed the National Inpat ...
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Journal articleWorld J Cardiol · December 26, 2025
BACKGROUND: Persistent sinus tachycardia affects up to 40% of patients after heart transplantation and is linked with graft dysfunction, impaired diastolic filling, and increased morbidity. Conventional rate-limiting therapies such as beta-blockers and cal ...
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ConferenceCirculation Heart Failure · October 1, 2025
BACKGROUND: – The atria play an important role in the pathophysiology of heart failure with preserved ejection fraction. Decreased left atrial strain is associated with worse clinical outcomes. The impact of no-implant interatrial shunting on atrial struct ...
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Journal articleAnesth Analg · October 1, 2025
BACKGROUND: The right ventricle-pulmonary artery (RV-PA) coupling ratio provides an assessment of RV function indexed to PA afterload. A low preoperative RV-PA ratio has been associated with increased mortality after transcatheter procedures. In patients u ...
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Journal articleCirc Heart Fail · October 2025
BACKGROUND: The atria play an important role in the pathophysiology of heart failure with preserved ejection fraction. Decreased left atrial strain is associated with worse clinical outcomes. The impact of no-implant interatrial shunting on atrial structur ...
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Journal articleJacc Basic to Translational Science · August 1, 2025
An admittance technology (AT) pulmonary artery catheter was developed to measure instantaneous right ventricular (RV) pressure-volume loops. Admittance RV volumes were validated in vivo through 10 swine subjected to positive and negative hemodynamic pertur ...
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Journal articlePLoS Negl Trop Dis · August 2025
INTRODUCTION: Chronic Chagas cardiomyopathy (CCC) is associated with a high incidence of cardiovascular events. Global longitudinal strain (GLS) is useful in predicting adverse cardiovascular outcomes in several cardiomyopathies. However, its prognostic va ...
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Journal articlePacing Clin Electrophysiol · July 2025
BACKGROUND: Left bundle branch area pacing (LBBAP) is increasingly used in patients with a ventricular pacing indication but necessitates precise septal localization. The resulting effects of intraoperative lead repositioning on septal fibrosis remain unkn ...
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ConferenceJACC Adv · May 2025
BACKGROUND: Hypertrophic cardiomyopathy (HCM) remains underdiagnosed, and artificial intelligence tools for echocardiographic recognition have been hampered by lack of insight into drivers of model predictions and ease of implementation. OBJECTIVES: The pu ...
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Journal articleFront Artif Intell · 2025
BACKGROUND: Accurate risk stratification in pulmonary hypertension (PH) is integral for optimizing therapeutic strategies and improving patient outcomes. Recent artificial intelligence (AI) models have demonstrated notable efficacy in risk stratification o ...
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Journal articleFront Artif Intell · 2025
INTRODUCTION: Pulmonary hypertension (PH) has an incidence of approximately 6 cases per million adults, with a global prevalence ranging from 49 to 55 cases per million adults. Recent advancements in artificial intelligence (AI) have demonstrated promising ...
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Journal articleJ Card Fail · October 2024
Our comprehension of atrial mechanics, atrial cardiomyopathy and their clinical implications across various cardiovascular conditions has advanced significantly. Atrial interventions can have differing effects on atrial mechanics. With the rapid increase i ...
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Journal articleEchocardiography · October 2024
INTRODUCTION: The hemodynamic effects of mitral valve repair (MVr) with respect to transmitral pressure gradients (TMPGs) have not been described well in patients undergoing leaflet preservation techniques. In a population of patients undergoing robotic MV ...
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Journal articleJCO Clin Cancer Inform · September 2024
PURPOSE: The magnitude of cardiorespiratory fitness (CRF) impairment during anticancer treatment and CRF response to aerobic exercise training (AT) are highly variable. The aim of this ancillary analysis was to leverage machine learning approaches to ident ...
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Journal articleMagn Reson Med · April 2024
PURPOSE: The interaction between 129 Xe atoms and pulmonary capillary red blood cells provides cardiogenic signal oscillations that display sensitivity to precapillary and postcapillary pulmonary hypertension. Recently, such oscillations have been spatiall ...
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Journal articleJ Cardiovasc Electrophysiol · November 2023
BACKGROUND: Traditional transvenous pacemakers are associated with worsening tricuspid valve function due to lead-related leaflet impingement, as well as ventricular dysfunction related to electromechanical dyssynchrony from chronic right ventricular (RV) ...
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Journal articleCirc Cardiovasc Imaging · August 2023
BACKGROUND: Patients with a working diagnosis of myocardial infarction with unobstructed coronary arteries (MINOCA) represent a heterogeneous cohort. The prognosis could vary substantially depending on the underlying cause. Although cardiac magnetic resona ...
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Journal articleClin Transplant · May 2023
BACKGROUND: Heart transplantation (HT) has historically been limited by organ availability. Use of donation after circulatory death (DCD) donors addresses this limitation by utilizing previously unused hearts through use of the Organ Care System (OCS). OBJ ...
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Journal articleJ Heart Lung Transplant · April 2023
BACKGROUND: Right atrial (RA) imaging has emerged as a promising tool for the evaluation of patients with pulmonary hypertension (PH), albeit without systematic validation. METHODS: PubMed, Web of Science and the Cochrane library were searched for studies ...
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Journal articleEur Heart J Cardiovasc Imaging · December 19, 2022
AIMS: Precapillary pulmonary hypertension (pPH) affects left ventricular (LV) function by ventricular interdependence. Since LV ejection fraction (EF) is commonly preserved, LV dysfunction should be assessed with more sensitive techniques. Left atrial (LA) ...
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Journal articleJ Card Surg · December 2022
Septal myectomy is currently the gold standard treatment for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). The procedure needs to be tailored and performed in a personalized fashion, taking into consideration the anatomic and ph ...
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Journal articleRadiology · November 2022
Background The relationship between papillary muscle infarction (papMI) and the culprit coronary lesion has not been fully investigated. Delayed enhancement cardiac MRI may detect papMI, yet its accuracy is unknown. Flow-independent dark-blood delayed enha ...
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Journal articleNMR Biomed · October 2022
Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat are available, it woul ...
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Journal articleCurr Atheroscler Rep · October 2022
PURPOSE OF REVIEW: The intent of this review is to provide an update in polypharmacy in older adults and women with a focus on common determinants and strategies to mitigate polypharmacy. RECENT FINDINGS: Polypharmacy is becoming a critical focus in the ma ...
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Journal articleAnn Noninvasive Electrocardiol · July 2022
BACKGROUND: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be abl ...
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Journal articleApplications in Engineering Science · June 1, 2022
Most cardiac diseases affect the left ventricle (LV), with its treatment being the focus of the majority of cardiovascular medical therapies and mechanical support. Many diseases also affect the right ventricle (RV) and pulmonary circulation, either direct ...
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Journal articleCirc Res · April 29, 2022
There is an increased appreciation for the importance of the right heart and pulmonary circulation in several disease states across the spectrum of pulmonary hypertension and left heart failure. However, assessment of the structure and function of the righ ...
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ConferenceERJ Open Res · April 2022
BACKGROUND: The diagnosis of pulmonary hypertension (PH) remains challenging. Pre- and post-capillary PH have different signatures on noninvasive 129Xe gas-exchange magnetic resonance imaging (MRI) and dynamic MR spectroscopy (MRS). We tested the accuracy ...
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Journal articleEchocardiography · February 2022
OBJECTIVE: People living with HIV (PLWH) are at increased risk for cardiac dysfunction. It is unknown how their global longitudinal cardiac function, cardiac structure, and other indices of function progress over time. We aimed to characterize the longitud ...
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Journal articlePLoS Negl Trop Dis · November 2020
UNLABELLED: Chagas disease (CD) will account for 200,000 cardiovascular deaths worldwide over the next 5 years. Early detection of chronic Chagas cardiomyopathy (CCC) is a challenge. We aimed to test if speckle-tracking echocardiography (STE) can detect in ...
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Journal articlePacing Clin Electrophysiol · September 2020
BACKGROUND: Cardiac amyloidosis is a progressive infiltrative disease involving deposition of amyloid fibrils in the myocardium and cardiac conduction system that frequently manifests with heart failure (HF) and arrhythmias, most frequently atrial fibrilla ...
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Journal articleJ Am Coll Cardiol · August 18, 2020
BACKGROUND: Monogenic diseases are individually rare but collectively common, and are likely underdiagnosed. OBJECTIVES: The purpose of this study was to estimate the prevalence of monogenic cardiovascular diseases (MCVDs) and potentially missed diagnoses ...
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Journal articleEur J Heart Fail · July 2020
AIMS: Worsening heart failure (HF) is associated with shorter left ventricular systolic ejection time (SET), but there are limited data describing the relationship between SET and clinical outcomes. Thus, the objective was to describe the association betwe ...
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Journal articleJ Card Fail · March 2020
BACKGROUND: Although left atrial (LA) mechanical dysfunction in heart failure with preserved ejection fraction (HFpEF) is associated with poor clinical outcomes, the influence of LA myopathy on temporal changes in cardiovascular biomarkers is unclear. METH ...
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Journal articleHeart International · January 1, 2020
Aortic stenosis and coronary artery disease (CAD) frequently co-exist, as they share a common pathophysiology and risk factors. Due to lack of randomised controlled trials (RCTs) and exclusion of significant CAD in transcatheter aortic valve replacement (T ...
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Journal articleAm J Cardiol · September 15, 2019
Improvement in survival in patients living with human immunodeficiency virus (PLHIV) has led to increased prevalence of cardiovascular disease. Whether HIV-associated immune dysfunction is associated with preclinical left ventricular (LV) dysfunction despi ...
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Journal articleCurrent Cardiovascular Imaging Reports · September 1, 2019
Purpose of Review: Despite significant advances in stent design and procedural technique, stent failure remains the “Achilles’ heel” of percutaneous coronary intervention (PCI). It is important to understand the mechanism of stent failure to prevent major ...
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Journal articleAm J Cardiol · March 1, 2019
The introduction of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of patients with severe aortic stenosis (AS). However, despite the great clinical success of TAVI, less is known about the cardiac hemodynamics and structur ...
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Journal articleCirc Cardiovasc Imaging · November 2018
Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent of RA size in pulmonary arterial hypertension is not known. Methods and Results Study subjects with pul ...
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Journal articleAm J Cardiol · September 1, 2018
In pulmonary hypertension (PH), measurement of various echocardiographic parameters that assess right heart function is recommended by current clinical guidelines. Limited data exists on the combined value of clinical and echocardiographic parameters in pr ...
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Journal articleJ Card Fail · August 2018
OBJECTIVE: The aim of this work was to investigate determinants of structural myocardial abnormalities in persons living with human immunodeficiency virus (PLWH). METHODS AND RESULTS: We reviewed archived transthoracic echocardiograms (TTEs) performed on P ...
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Book section · January 1, 2018
Measurement of myocardial global longitudinal strain (GLS) is no longer a research tool. Rather, GLS is now used for risk assessment and management of patients with a wide variety of clinical disorders. GLS is clearly a useful supplement to routine quantit ...
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ConferenceESC Heart Fail · November 2017
AIMS: While abnormal resting LV GLS has been described in patients with chronic heart failure with preserved ejection fraction (HFpEF), its prognostic significance when measured during an acute heart failure hospitalization remains unclear. We assessed the ...
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Journal articleAm J Cardiol · November 1, 2017
Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annula ...
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ConferenceEur J Heart Fail · July 2017
BACKGROUND: While abnormal left ventricular (LV) global longitudinal strain (GLS) has been described in patients with heart failure with preserved ejection fraction (HFpEF), its prevalence and clinical significance are poorly understood. METHODS AND RESULT ...
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Journal articleIndoor Air · July 2017
While household air pollution from biomass fuel combustion has been linked to cardiovascular disease, the effects on cardiac structure and function have not been well described. We sought to determine the association between biomass fuel smoke exposure and ...
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ConferenceClin Transplant · May 2017
BACKGROUND: Cardiac allografts are routinely evaluated by left ventricular ejection fraction (LVEF) before and after transplantation. However, myocardial deformation analyses with LV global longitudinal strain (GLS) are more sensitive for detecting impaire ...
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Journal articleSemin Respir Crit Care Med · February 2017
Acute pulmonary embolism (PE) is a major cause of morbidity and mortality and is classified as massive (high risk), submassive (intermediate risk), or nonmassive (low risk) based on the hemodynamic status and clinical characteristics of the patient. At thi ...
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Journal articleJournal of the Indian Academy of Echocardiography and Cardiovascular Imaging · January 1, 2017
Introduction: Strain is a unitless measurement of dimensional or deformational change; speckle-Tracking echocardiography is the most widely used technique to assess strain, with demonstrated clinical utility in a variety of settings. Objectives: This paper ...
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Journal articleJACC Heart Fail · August 2015
Successful combination therapy for human immunodeficiency virus (HIV) has transformed this disease from a short-lived infection with high mortality to a chronic disease associated with increasing life expectancy. This is true for high- as well as low- and ...
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Journal articleJ Electrocardiol · 2015
BACKGROUND: New-onset left bundle branch block (LBBB) is a known complication during Transcatheter Aortic Valve Replacement (TAVR). This study evaluated the influence of pre-TAVR cardiac conditions on left ventricular functions in patients with new persist ...
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