Scholars@Duke
Sharon Fekrat

Sharon Fekrat

Robert Machemer, MD, Distinguished Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
sharon.fekrat@duke.edu
DUMC 3802, Durham, NC 27710
Hudson Building, Box 3802, Duke Eye Center, Erwin Road, Durham, NC 27710-3802

Scholarly Works - Journal articles

Four-year evolution of the retinal microvasculature in an APOE ε4/ε4 cognitively normal individual.

Journal article BMJ Case Rep · August 19, 2026 Alzheimer's disease is a neurodegenerative disorder with a prolonged preclinical phase during which pathological changes begin 15-20 years before clinical presentation. We present longitudinal optical coherence tomography angiography (OCTA) images from a c ... Full text Link to item Cite

Contemporary diversity trends among matched ophthalmology residents in the USA.

Journal article BMJ Lead · June 26, 2026 BACKGROUND: Ophthalmology remains one of the least diverse medical specialties, despite ongoing efforts to promote inclusion. To address the gap in recent literature and understand the demographic trajectory of this specialty, this study analyses current d ... Full text Link to item Cite

RETINAL DETACHMENT AFTER ENDOGENOUS ENDOPHTHALMITIS: A Multicenter Study.

Journal article Retina · June 1, 2026 PURPOSE: To assess factors associated with retinal detachment (RD) in eyes presenting with endogenous endophthalmitis (EE). METHODS: Multicenter retrospective study of individuals with an EE diagnosis from seven tertiary care centers. Demographics, medical ... Full text Link to item Cite

Effect of Intravitreal Anti-VEGF Injections on the Vitreomacular Interface in Treatment-Naïve Eyes With Central Retinal Vein Occlusion.

Journal article J Vitreoretin Dis · May 19, 2026 Purpose: To assess the impact of repeated intravitreal (IVT) antivascular endothelial growth factor (anti-VEGF) injections on the vitreomacular interface in eyes with cystoid macular edema secondary to central retinal vein occlusion (CRVO). Methods: This r ... Full text Link to item Cite

Cerebrospinal fluid amyloid-β 42/40 ratio is associated with ganglion cell-inner plexiform layer thinning in individuals with and without amyloid pathology.

Journal article J Alzheimers Dis · April 2026 BackgroundRetinal imaging offers a noninvasive window into neurodegenerative changes, yet its relationship with established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) remains poorly understood. This study addresses a critical gap by e ... Full text Link to item Cite

Posttraumatic Stress Disorder and Macular, Choroidal, and Peripapillary Perfusion Using Optical Coherence Tomography and Angiography.

Journal article Ophthalmic Surg Lasers Imaging Retina · April 2026 BACKGROUND AND OBJECTIVE: Posttraumatic stress disorder (PTSD) is a chronic psychiatric condition associated with long-term neurobiological and neurovascular changes. In this study, optical coherence tomography (OCT) and OCT angiography (OCTA) were used to ... Full text Link to item Cite

Longitudinal Multimodal Imaging Findings Following Inadvertent 577 nm Laser Backscatter Exposure During Panretinal Laser Photocoagulation.

Journal article J Vitreoretin Dis · March 30, 2026 Purpose: To report an unusual case of retinal dysfunction in a treating ophthalmologist following inadvertent exposure to 577 nm yellow laser backscatter during panretinal photocoagulation. Methods: A single case was reviewed. Results: A 28-year-old physic ... Full text Link to item Cite

RETINAL DIAGNOSTICS IN ALZHEIMER DISEASE: WHERE ARE WE NOW?

Journal article Retina Today · March 1, 2026 Here’s how imaging is helping pave the path forward. ... Cite

Visual Outcomes in Cases of Endogenous Endophthalmitis: A Multicenter Study.

Journal article Ophthalmol Retina · January 2026 PURPOSE: To assess factors affecting visual outcomes in endogenous endophthalmitis (EE). DESIGN: Retrospective cohort study from 8 tertiary care centers. PARTICIPANTS: Eyes with EE and at least 4 weeks of follow-up. METHODS: Demographics, visual acuity (VA ... Full text Link to item Cite

Choroidal vascularity index as a marker of health and disease: systematic review and meta-analyses.

Journal article Surv Ophthalmol · 2026 The Choroidal Vascularity Index (CVI), derived from optical coherence tomography (OCT), has emerged as a potential biomarker for detecting vascular changes. Understanding its variability across physiological states, ocular conditions, and systemic diseases ... Full text Link to item Cite

Comparison of Longitudinal Retinal and Choroidal Imaging Findings in Patients With Mild Cognitive Impairment and Cognitively Normal Control Participants

Journal article Journal of Vitreoretinal Diseases · January 1, 2026 Purpose: To compare longitudinal retinal and choroidal imaging findings in patients with mild cognitive impairment and cognitively normal control participants. Methods: Eyes of patients with mild cognitive impairment and cognitively normal controls were im ... Full text Cite

Treatment Patterns and Long-term Outcomes with Anti-VEGF Therapy for Retinal Vein Occlusion: An Analysis of the Vestrum Database.

Journal article Ophthalmol Retina · December 2025 PURPOSE: To evaluate anti-VEGF treatment patterns and long-term visual acuity (VA) outcomes in retinal vein occlusion (RVO) in routine clinical practice. DESIGN: Retrospective observational study of the Vestrum Health Retina database. SUBJECTS: Treatment-n ... Full text Link to item Cite

Biomarkers.

Journal article Alzheimers Dement · December 2025 BACKGROUND: We assessed differences in retinal structure and microvasculature among individuals with Alzheimer's disease (AD), APOE ε4 carriers, and APOE ε4 noncarriers. METHOD: Participants underwent cognitive evaluation with Mini-Mental State Examination ... Full text Link to item Cite

A Dual-Center Study of Retinal Detachment Following Endogenous Endophthalmitis.

Journal article Ocul Immunol Inflamm · September 2025 PURPOSE: To evaluate factors associated with increased odds of retinal detachment (RD) following endogenous endophthalmitis (EE). METHODS: Retrospective study of individuals with EE from two tertiary care centers. Demographics, medical and ocular history, ... Full text Link to item Cite

Dopaminergic Therapies May Decrease Risk of Early and Intermediate Non-exudative Age-related Macular Degeneration Progression.

Journal article Ophthalmic Surg Lasers Imaging Retina · July 2025 BACKGROUND AND OBJECTIVE: Age-related macular degeneration (AMD) is a leading cause of vision loss, with progression to geographic atrophy (GA) posing a significant challenge. This study aimed to assess whether dopaminergic therapies (DMTs) reduce risk of ... Full text Link to item Cite

Correlating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer's disease and amnestic mild cognitive impairment.

Journal article BMC Ophthalmol · July 1, 2025 BACKGROUND: We assess the relationships between retinal and choroidal structural and microvascular parameters and brain volumetric magnetic resonance imaging (MRI) parameters in individuals with amnestic mild cognitive impairment (aMCI) and Alzheimer's dis ... Full text Link to item Cite

Characteristics Associated With Endowed Chair Titles Among U.S. Academic Ophthalmologists.

Journal article Cureus · June 2025 INTRODUCTION: Over the last several decades, the number of women in ophthalmology has gradually increased. However, studies have demonstrated that far fewer women than men are represented in senior leadership positions. Having an endowed chair facilitates ... Full text Link to item Cite

Trends in Choroidal Vascularity Index in Cognitively Normal Individuals.

Journal article Retina · March 4, 2025 PURPOSE: To establish a normative database of choroidal vascularity index (CVI) in cognitively normal adults. METHODS: Cognitively healthy volunteers who had a Montreal Cognitive Assessment (MoCA) score of 23 or higher were included. Exclusion criteria inc ... Full text Link to item Cite

Clinical Features Associated With Return to Pre-endophthalmitis Visual Acuity Following Presumed Infectious Endophthalmitis.

Journal article Ophthalmic Surg Lasers Imaging Retina · March 2025 BACKGROUND AND OBJECTIVE: This study aimed to investigate clinical characteristics associated with return to pre-endophthalmitis visual acuity (VA) following treatment for presumed infectious endophthalmitis. PATIENTS AND METHODS: This was a retrospective ... Full text Link to item Cite

Evaluating the Impact of Gender and Race on Otolaryngology Resident Experiences Across the United States.

Journal article Otolaryngol Head Neck Surg · January 2025 OBJECTIVE: Otolaryngology residents often encounter work-related stress and challenges during training. Sociodemographic factors influence experiences during residency; however, the impact of race and gender on otolaryngology trainee well-being during resi ... Full text Link to item Cite

The elusive relationship between retinal anatomy and brain amyloid.

Journal article Brain Commun · 2025 This scientific commentary refers to 'Retinal microstructure and microvasculature in association with brain amyloid burden', by Egle et al. (https://doi.org/10.1093/braincomms/fcaf013). ... Full text Link to item Cite

Possible Association Between Dopamine Antagonists and Increased Conversion to Exudative Age-Related Macular Degeneration.

Journal article J Vitreoretin Dis · 2025 Purpose: To investigate whether modulating dopamine signaling affects conversion to exudative age-related macular degeneration (AMD). Methods: A retrospective cohort study was performed using the Duke Epic database. Eyes from patients with a diagnosis of n ... Full text Link to item Cite

Regulatory Considerations of Non-Fungible Tokens in Healthcare

Journal article Journal of Medical Regulation · January 1, 2025 Purpose: To combine the perspectives of health and commercialization experts on the ethical and regulatory needs for non-fungible token (NFT) implementation in healthcare. Design: Perspective Methods: For a multidisciplinary perspective by an interdiscipli ... Full text Cite

Oral Antithrombotic Medication Is Associated with Improved Visual Outcomes in Eyes with Submacular Hemorrhage from Wet Age-Related Macular Degeneration.

Journal article Ophthalmol Sci · 2025 PURPOSE: To determine differences in visual acuity (VA) outcomes in eyes of patients on antithrombotics (antiplatelet agents and anticoagulants) that develop submacular hemorrhage (SMH) compared with eyes of patients who are not on antithrombotics and deve ... Full text Link to item Cite

Reply.

Journal article Ophthalmol Sci · 2025 Full text Link to item Cite

Retinal Layer Thickness and Volume Measurements in Traumatic Brain Injury.

Journal article J Vitreoretin Dis · 2025 Purpose: To assess retinal layer thickness and volume by optical coherence tomography (OCT) in patients with prior traumatic brain injury (TBI). Methods: Adults (≥18 years) with prior TBI were prospectively recruited. 512 × 128-mm macular cube scans were o ... Full text Link to item Cite

Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends.

Journal article Prog Retin Eye Res · November 2024 Alzheimer's disease (AD) is the leading cause of dementia worldwide. Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal ... Full text Link to item Cite

ORAL CURCUMIN TO REDUCE RISK OF PROLIFERATIVE VITREORETINOPATHY FOLLOWING RHEGMATOGENOUS RETINAL DETACHMENT REPAIR.

Journal article Retina · October 1, 2024 PURPOSE: To evaluate outcomes of patients who underwent rhegmatogenous retinal detachment repair and were started on oral curcumin for proliferative vitreoretinopathy (PVR) prevention. METHODS: Retrospective, observational case series of eyes of patients u ... Full text Link to item Cite

Evaluating the Impact of Gender, Race, and Training Year on Internal Medicine Residents' Experiences Across the United States.

Journal article Perm J · September 16, 2024 INTRODUCTION: Prior studies have highlighted experiences of bias within resident training based on trainees' gender and race and high rates of burnout. However, few studies have addressed the intersection between bias and wellness for residents in internal ... Full text Link to item Cite

Incidence, risk factors, and treatment of retroprosthetic membranes following Boston keratoprosthesis eyes and the impact of glaucoma surgery.

Journal article Graefes Arch Clin Exp Ophthalmol · August 2024 PURPOSE: To assess incidence, risk factors, and treatment of retroprosthetic membrane (RPM) formation in eyes following Boston keratoprosthesis (Kpro) implantation and their correlation with glaucoma drainage device placement (GDD). METHODS: A retrospectiv ... Full text Link to item Cite

Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis.

Journal article Cureus · August 2024 PURPOSE: Report the clinical findings, risk factors, treatment, and visual outcomes associated with Streptococcus endophthalmitis in comparison to culture-positive endophthalmitis associated with non-Streptococcus species. METHODS: A retrospective chart re ... Full text Open Access Link to item Cite

Multimodal Retinal Imaging Classification for Parkinson's Disease Using a Convolutional Neural Network.

Journal article Transl Vis Sci Technol · August 1, 2024 PURPOSE: Changes in retinal structure and microvasculature are connected to parallel changes in the brain. Two recent studies described machine learning algorithms trained on retinal images and quantitative data that identified Alzheimer's dementia and mil ... Full text Link to item Cite

Peripapillary Optical Coherence Tomography Angiography in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Cognition.

Journal article Ophthalmic Surg Lasers Imaging Retina · February 2024 OBJECTIVE: This study aimed to identify peripapillary microvascular changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). PATIENTS AND METHODS: In this prospective study, 66 eyes of 36 subjects with AD, 119 eyes of 63 with MCI, and 513 e ... Full text Link to item Cite

Longitudinal Retinal and Choroidal Image Analysis in a Set of Monozygotic Twins.

Journal article Cureus · February 2024 We analyzed multimodal retinal and choroidal imaging, including optical coherence tomography (OCT) and OCT angiography (OCTA), to assess differences and characterize variations in the retinal and choroidal structure and microvasculature between healthy mon ... Full text Link to item Cite

Ultra-Widefield Imaging of the Retinal Macrovasculature in Parkinson Disease Versus Controls With Normal Cognition Using Alpha-Shapes Analysis.

Journal article Transl Vis Sci Technol · January 2, 2024 PURPOSE: To investigate retinal vascular characteristics using ultra-widefield (UWF) scanning laser ophthalmoscopy in Parkinson disease (PD). METHODS: Individuals with an expert-confirmed clinical diagnosis of PD and controls with normal cognition without ... Full text Link to item Cite

IMPLICATIONS OF COMPLETE POSTERIOR VITREOUS DETACHMENT IN EYES WITH CENTRAL RETINAL VEIN OCCLUSION.

Journal article Retina · January 1, 2024 BACKGROUND/PURPOSE: To evaluate the status of the posterior vitreous hyaloid on presenting optical coherence tomography images of the macula and its relationship to clinical characteristics, treatment patterns, and outcomes in eyes with central retinal vei ... Full text Link to item Cite

A Convolutional Neural Network Using Multimodal Retinal Imaging for Differentiation of Mild Cognitive Impairment from Normal Cognition.

Journal article Ophthalmol Sci · 2024 PURPOSE: To develop a machine learning tool capable of differentiating eyes of subjects with normal cognition from those with mild cognitive impairment (MCI) using OCT and OCT angiography (OCTA). DESIGN: Evaluation of a diagnostic technology. PARTICIPANTS: ... Full text Link to item Cite

Acute, Treatment-Naïve Branch Retinal Vein Occlusion in Younger Individuals: Risk Factors and Clinical Outcomes.

Journal article J Vitreoretin Dis · 2024 Purpose: To compare the risk factors and clinical outcomes in patients younger than 50 years with acute, treatment-naïve branch retinal vein occlusion (BRVO) with outcomes in patients 50 years or older. Methods: Patients diagnosed with acute, treatment-naï ... Full text Link to item Cite

Differences in Retinal and Choroidal Microvasculature and Structure in Dementia With Lewy Bodies Compared With Normal Cognition.

Journal article J Vitreoretin Dis · 2024 Purpose: To evaluate the retinal and choroidal microvasculature and structure in individuals with dementia with Lewy bodies (DLB) compared with controls with normal cognition using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: An ... Full text Open Access Link to item Cite

Characterizing differences in retinal and choroidal microvasculature and structure in individuals with Huntington's Disease compared to healthy controls: A cross-sectional prospective study.

Journal article PLoS One · 2024 OBJECTIVE: To characterize retinal and choroidal microvascular and structural changes in patients who are gene positive for mutant huntingtin protein (mHtt) with symptoms of Huntington's Disease (HD). METHODS: This study is a cross-sectional comparison of ... Full text Link to item Cite

Analysis of the Retinal and Choroidal Vasculature Using Ultrawidefield Fundus Imaging in Mild Cognitive Impairment and Normal Cognition.

Journal article Ophthalmol Sci · 2024 PURPOSE: To utilize ultrawidefield (UWF) imaging to evaluate retinal and choroidal vasculature and structure in individuals with mild cognitive impairment (MCI) compared with that of controls with normal cognition. DESIGN: Prospective cross sectional study ... Full text Link to item Cite

Aqueous and Plasma Levels of Phosphorylated Tau 181 in Individuals with Normal Cognition.

Journal article J Alzheimers Dis · 2024 BACKGROUND: Plasma and cerebrospinal fluid (CSF) levels of p-tau181 have been associated with Alzheimer's disease (AD). The retina and vitreous have shown measurable quantities of phosphorylated tau 181 (p-tau181). The aqueous humor, which can be collected ... Full text Link to item Cite

Risk Factors for Progression of Vitreomacular Traction to Macular Hole.

Journal article J Vitreoretin Dis · 2024 Purpose: To evaluate the clinical and optical coherence tomography (OCT) characteristics associated with progression of vitreomacular traction (VMT) to a full-thickness macular hole (FTMH) and lamellar macular hole (LMH). Methods: A retrospective cohort st ... Full text Link to item Cite

Longitudinal Assessment of Peripapillary Microvasculature Using Optical Coherence Tomography Angiography in Cognitively Normal Adults.

Journal article J Vitreoretin Dis · 2024 Introduction: To evaluate longitudinal peripapillary changes in cognitively normal older adults using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: Participants older than 50 years with no history of neurodegenerative disease or c ... Full text Link to item Cite

Introduction

Journal article Curbside Consultation in Retina Book Curbside Consultation in Retina 49 Clinical Questions · January 1, 2024 Cite

Visual outcomes of primary keratoprosthesis implantation in transplant-naïve eyes.

Journal article PLoS One · 2024 PURPOSE: Primary keratoprosthesis (Kpro) implantation may be indicated in eyes that have an expected poor prognosis following initial penetrating keratoplasty, such as eyes with limbal stem cell deficiency (LSCD). We compare visual outcomes of eyes undergo ... Full text Link to item Cite

Macular, Choroidal, and Peripapillary Perfusion Changes in Mild and Moderate Traumatic Brain Injury Using Optical Coherence Tomography and Angiography.

Journal article J Vitreoretin Dis · 2024 Introduction: To compare the retinal and choroidal architecture and microvasculature between patients with mild or moderate traumatic brain injury (TBI) and controls with normal cognition using optical coherence tomography (OCT) and OCT angiography (OCTA). ... Full text Link to item Cite

Angioarchitectural alterations in the retina and choroid in frontotemporal dementia.

Journal article PLoS One · 2024 OBJECTIVE: Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder that affects the frontal and temporal lobes of the brain, leading to cognitive decline and personality changes. The objective of this cross-sectional study was to characte ... Full text Open Access Link to item Cite

Correction: Angioarchitectural alterations in the retina and choroid in frontotemporal dementia.

Journal article PLoS One · 2024 [This corrects the article DOI: 10.1371/journal.pone.0312118.]. ... Full text Link to item Cite

Longitudinal Analysis of Retinal Microvascular and Choroidal Imaging Parameters in Parkinson's Disease Compared with Controls.

Journal article Ophthalmol Sci · December 2023 PURPOSE: To quantify rate of change of retinal microvascular and choroidal structural parameters in subjects with Parkinson's disease (PD) compared with controls using OCT and OCT angiography (OCTA). DESIGN: Prospective longitudinal study. PARTICIPANTS: Se ... Full text Link to item Cite

ENDOGENOUS ENDOPHTHALMITIS ASSOCIATED WITH INJECTION DRUG USE COMPARED WITH OTHER ETIOLOGIES.

Journal article Retina · November 1, 2023 PURPOSE: To compare features of endogenous endophthalmitis associated with injection drug use (IDU) to endogenous endophthalmitis from other etiologies. METHODS: The authors retrospectively collected data on patients with endogenous endophthalmitis due to ... Full text Link to item Cite

Longitudinal Assessment of the Choroidal Vascularity Index in Eyes with Branch Retinal Vein Occlusion-Associated Cystoid Macular Edema.

Journal article Ophthalmol Ther · August 2023 INTRODUCTION: Cystoid macular edema (CME) is the most common cause of central vision loss in eyes with branch retinal vein occlusion (BRVO eyes). In recent literature, choroidal vascularity index (CVI) has been proposed to be an enhanced depth imaging opti ... Full text Link to item Cite

Intrasession Repeatability of OCT Angiography Parameters in Neurodegenerative Disease.

Journal article Ophthalmol Sci · June 2023 PURPOSE: To assess the intrasession repeatability of macular OCT angiography (OCTA) parameters in Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), and normal cognition (NC). DESIGN: Cross sectional study. SUBJECTS: Patie ... Full text Open Access Link to item Cite

Convolutional Neural Network-Based Automated Quality Assessment of OCT and OCT Angiography Image Maps in Individuals With Neurodegenerative Disease.

Journal article Transl Vis Sci Technol · June 1, 2023 PURPOSE: To train and test convolutional neural networks (CNNs) to automate quality assessment of optical coherence tomography (OCT) and OCT angiography (OCTA) images in patients with neurodegenerative disease. METHODS: Patients with neurodegenerative dise ... Full text Link to item Cite

Retinal Vascular Changes in Alzheimer's Dementia and Mild Cognitive Impairment: A Pilot Study Using Ultra-Widefield Imaging.

Journal article Transl Vis Sci Technol · January 3, 2023 PURPOSE: Retinal microvascular abnormalities measured on retinal images are a potential source of prognostic biomarkers of vascular changes in the neurodegenerating brain. We assessed the presence of these abnormalities in Alzheimer's dementia and mild cog ... Full text Link to item Cite

Asymmetric Purtscher-Like Retinopathy Caused by a Hypertensive Emergency and Undiagnosed Type 2 Diabetes.

Journal article J Vitreoretin Dis · 2023 Purpose: To report a case of Purtscher-like retinopathy (PLR) in the setting of a hypertensive emergency and undiagnosed type 2 diabetes mellitus (DM). Methods: A case was analyzed. Results: A 29-year-old, obese, hypertensive man presented with a 10-day hi ... Full text Link to item Cite

Resident Vitreoretinal Procedure Volume: Effect of Intravitreal Injections, Region, Program Size, and Vitreoretinal Fellowship and Veterans Affairs Affiliation.

Journal article J Acad Ophthalmol (2017) · January 2023 Purpose  To analyze resident vitreoretinal procedure volume across Accreditation Council of Graduate Medical Education (ACGME) accredited ophthalmology residency programs. We assessed the effect of the increase in intravitreal injections (IVI), geographic ... Full text Link to item Cite

Artificial intelligence in dementia.

Journal article Curr Opin Ophthalmol · September 1, 2022 PURPOSE OF REVIEW: Artificial intelligence tools are being rapidly integrated into clinical environments and may soon be incorporated into dementia diagnostic paradigms. A comprehensive review of emerging trends will allow physicians and other healthcare p ... Full text Link to item Cite

Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.

Journal article Ophthalmol Retina · July 2022 PURPOSE: To assess the baseline differences and longitudinal rate of change in retinal and choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and noncarriers with normal cognition. DESIGN: Prospective study. SUBJECTS: Four hundred th ... Full text Link to item Cite

ASSESSMENT OF RETINAL MICROVASCULAR ALTERATIONS IN INDIVIDUALS WITH AMNESTIC AND NONAMNESTIC MILD COGNITIVE IMPAIRMENT USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Journal article Retina · July 1, 2022 PURPOSE: To assess retinal microvascular alterations in individuals with amnestic mild cognitive impairment (MCI) and nonamnestic MCI. METHODS: One hundred twelve eyes of 59 amnestic MCI participants, 32 eyes of 17 nonamnestic MCI participants, and 111 eye ... Full text Link to item Cite

Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging.

Journal article Br J Ophthalmol · March 2022 BACKGROUND/AIMS: To develop a convolutional neural network (CNN) to detect symptomatic Alzheimer's disease (AD) using a combination of multimodal retinal images and patient data. METHODS: Colour maps of ganglion cell-inner plexiform layer (GC-IPL) thicknes ... Full text Open Access Link to item Cite

Reply.

Journal article Retina · March 1, 2022 Full text Link to item Cite

Retinal and Choroidal Changes in Men Compared with Women with Alzheimer's Disease: A Case-Control Study.

Journal article Ophthalmol Sci · March 2022 PURPOSE: To evaluate differences in the retinal microvasculature and structure and choroidal structure among men and women with Alzheimer's disease (AD) compared with age-matched cognitively normal male and female controls. DESIGN: Case-control study of pa ... Full text Open Access Link to item Cite

Choroidal vascularity index: a step towards software as a medical device.

Journal article Br J Ophthalmol · February 2022 The choroidal vascularity index (CVI) is a relatively new parameter, calculated off optical coherence tomography (OCT) images, for the quantitative evaluation of choroid vascularity. It is defined as the ratio of vascular area to the total choroidal area, ... Full text Link to item Cite

CLINICAL CHARACTERISTICS AND VISUAL OUTCOMES IN ENDOPHTHALMITIS AFTER KERATOPROSTHESIS IMPLANTATION.

Journal article Retina · February 1, 2022 PURPOSE: To describe the presentation, microbiology, management, and prognosis of eyes with endophthalmitis after Boston keratoprosthesis implantation. METHODS: Retrospective case series with history, diagnostics, management, and outcomes data in endophtha ... Full text Link to item Cite

Identifying Peripapillary Radial Capillary Plexus Alterations in Parkinson's Disease Using OCT Angiography.

Journal article Ophthalmol Retina · January 2022 PURPOSE: To compare radial peripapillary capillary (RPC) plexus vascular parameters and retinal nerve fiber layer (RNFL) thickness between those with Parkinson's disease (PD) and controls. DESIGN: Prospective, cross-sectional study. PARTICIPANTS: A total o ... Full text Link to item Cite

The effect of select systemic medications on outcomes in diabetics with central retinal vein occlusion.

Journal article Ther Adv Ophthalmol · 2022 BACKGROUND: Diabetes mellitus is a risk factor for central retinal vein occlusion (CRVO); however, it is unclear whether certain commonly used medications among diabetics or glycemic control impact visual outcomes in diabetic eyes with CRVO. PURPOSE: To ev ... Full text Open Access Link to item Cite

Multimodal Imaging of West African Crystalline Maculopathy in an Igbo Man.

Journal article J Vitreoretin Dis · 2022 PURPOSE: This report describes a case of West African crystalline maculopathy. METHODS: A case report is presented. RESULTS: A 71-year-old Nigerian man was referred for evaluation of bilateral crystalline retinal deposits seen on routine examination. The p ... Full text Link to item Cite

Management Patterns and Outcomes for Intravitreal Injection-Related Endophthalmitis.

Journal article J Vitreoretin Dis · 2022 PURPOSE: This work describes the clinical management and outcomes in cases of presumed infectious endophthalmitis following intravitreal injection at a tertiary academic medical center. METHODS: A retrospective review took place of eyes that presented to t ... Full text Link to item Cite

Mycobacterium chelonae Endogenous Endophthalmitis in a Person Addicted to Intravenous Drugs Presenting as an Intraretinal Peripapillary Granuloma With Tractional Retinal Detachment.

Journal article J Vitreoretin Dis · 2022 PURPOSE: To report a case of Mycobacterium chelonae endogenous endophthalmitis in a 28-year-old man with recent intravenous drug use that presented as an intraretinal peripapillary granuloma extending from the optic nerve head with an associated macular tr ... Full text Link to item Cite

Central Retinal Vein Occlusion: The Effect of Antiplatelet and Anticoagulant Agents.

Journal article J Vitreoretin Dis · 2022 PURPOSE: This work evaluates the effect of antiplatelet and anticoagulant agents on clinical outcomes, optical coherence tomography (OCT) parameters, and macular ischemia in eyes with central retinal vein occlusion (CRVO). METHODS: A retrospective longitud ... Full text Link to item Cite

Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease.

Journal article Ophthalmol Sci · December 2021 PURPOSE: To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition. DESIGN: Cross-sectional. PARTICIPANTS: Patients with a clinical ... Full text Open Access Link to item Cite

Characteristics of Branch Retinal Vein Occlusion in African American Patients.

Journal article Ophthalmic Surg Lasers Imaging Retina · September 2021 BACKGROUND AND OBJECTIVES: To describe the presentation, management, and clinical outcomes of branch retinal vein occlusion (BRVO) in African American patients compared to patients of other racial or ethnic backgrounds. PATIENTS AND METHODS: This retrospec ... Full text Link to item Cite

Assessing the Retinal Microvasculature in Individuals With Early and Late-Onset Alzheimer's Disease.

Journal article Ophthalmic Surg Lasers Imaging Retina · June 2021 BACKGROUND AND OBJECTIVE: To evaluate retinal microvascular changes in early and late-onset Alzheimer's disease (AD). PATIENTS AND METHODS: Eighty-six eyes of 50 late-onset AD participants, 27 eyes of 15 early onset AD participants, and 111 eyes of 57 cogn ... Full text Link to item Cite

BILATERAL INTRAVITREAL 0.19-MG FLUOCINOLONE ACETONIDE IMPLANT FOR PERSISTENT NONDIABETIC CYSTOID MACULAR EDEMA AFTER VITRECTOMY.

Journal article Retin Cases Brief Rep · May 1, 2021 BACKGROUND/PURPOSE: Iluvien (Alimera Science, Alpharetta, GA) is an injectable, nonbiodegradable, sustained-release 0.19-mg fluocinolone acetonide intravitreal implant. Although currently approved by the Food and Drug Administration only for diabetic macul ... Full text Link to item Cite

Rhegmatogenous Retinal Detachment in the Setting of Endophthalmitis: Risk Factors and Visual Outcomes.

Journal article Ophthalmic Surg Lasers Imaging Retina · May 2021 BACKGROUND AND OBJECTIVE: To investigate risk factors for rhegmatogenous retinal detachment (RRD) and visual acuity (VA) in eyes with RRD after developing endophthalmitis. PATIENTS AND METHODS: Retrospective comparative study of 133 eyes with endophthalmit ... Full text Link to item Cite

Time to Presentation after Symptom Onset in Endophthalmitis: Clinical Features and Visual Outcomes.

Journal article Ophthalmol Retina · April 2021 PURPOSE: To investigate the impact of time from symptom onset to presentation on the clinical course and outcomes of eyes with endophthalmitis. DESIGN: Retrospective, longitudinal cohort study. PARTICIPANTS: One hundred thirty-three eyes of 130 patients wi ... Full text Link to item Cite

Effect of ICD-9 to ICD-10 Transition on Accuracy of Codes for Stage of Diabetic Retinopathy and Related Complications: Results from the CODER Study.

Journal article Ophthalmol Retina · April 2021 PURPOSE: When the International Classification of Diseases 9th Revision (ICD-9) transitioned to the International Classification of Diseases 10th Revision (ICD-10), there was a marked increase in the complexity of International Classification of Diseases ( ... Full text Link to item Cite

Choroidal Structural Analysis in Alzheimer Disease, Mild Cognitive Impairment, and Cognitively Healthy Controls.

Journal article Am J Ophthalmol · March 2021 PURPOSE: To assess choroidal structural parameters in symptomatic Alzheimer disease (AD), mild cognitive impairment (MCI), and cognitively healthy control subjects. DESIGN: Prospective cross-sectional study. METHODS: This study took place in an outpatient ... Full text Open Access Link to item Cite

Endophthalmitis After Descemet Stripping Endothelial Keratoplasty: Microbiological Yield and Visual Outcomes.

Journal article Am J Ophthalmol · February 2021 PURPOSE: To describe the clinical presentation, management, and visual outcomes of 6 eyes with endophthalmitis after Descemet stripping endothelial keratoplasty (DSEK). DESIGN: Retrospective case series. METHODS: Setting: Tertiary, academic eye center. Stu ... Full text Link to item Cite

Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease.

Journal article JAMA Ophthalmol · February 1, 2021 IMPORTANCE: Noninvasive retinal imaging may detect structural changes associated with Parkinson disease (PD) and may represent a novel biomarker for disease detection. OBJECTIVE: To characterize alterations in the structure and microvasculature of the reti ... Full text Link to item Cite

Management Patterns and Visual Outcomes of Endophthalmitis After Glaucoma Drainage Device Placement: A Case Series.

Journal article J Glaucoma · January 1, 2021 PURPOSE: To describe clinical presentation, management, and outcomes of eyes with endophthalmitis related to glaucoma drainage device (GDD) placement. PATIENTS AND METHODS: Retrospective chart review of patients diagnosed with GDD-related endophthalmitis a ... Full text Link to item Cite

Initial Presentation of Cutibacterium (Formerly Propionibacterium) acnes Endophthalmitis Twenty-One Years After Cataract Surgery.

Journal article Ophthalmic Surg Lasers Imaging Retina · January 1, 2021 The authors report a case of an 81-year-old female who presented with sudden onset of light perception vision and intraocular inflammation. After several months of continuing symptoms despite antibiotics, an aqueous tap culture grew Cutibacterium acnes. Th ... Full text Link to item Cite

The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review.

Journal article Alzheimers Dement (Amst) · 2021 INTRODUCTION: Discovering non-invasive and easily acquired biomarkers that are conducive to the accurate diagnosis of dementia is an urgent area of ongoing clinical research. One promising approach is retinal imaging, as there is homology between retinal a ... Full text Link to item Cite

Systemic antiplatelet agents and anticoagulants in eyes with branch retinal vein occlusion.

Journal article Ther Adv Ophthalmol · 2021 PURPOSE: The purpose of this study was to investigate the effect of systemic antiplatelet agents and anticoagulants on the structural and functional outcomes of eyes with branch retinal vein occlusion (BRVO). METHODS: A retrospective longitudinal cohort st ... Full text Link to item Cite

Multimodal imaging of type 2 acute macular neuroretinopathy in a young woman.

Journal article Digit J Ophthalmol · 2021 We report a case of type 2 acute macular neuroretinopathy (AMN) that occurred in an otherwise healthy 22-year-old white woman taking oral contraceptives and consuming large quantities of caffeinated coffee. The patient presented with a teardrop-shaped scot ... Full text Link to item Cite

Treatment Patterns and Clinical Outcomes for Branch Retinal Vein Occlusion: An 8-Year Experience at a Tertiary Eye Center.

Journal article J Vitreoretin Dis · 2021 PURPOSE: This work aims to investigate real-world treatment patterns and outcomes in eyes with branch retinal vein occlusion in the antivascular endothelial growth factor (anti-VEGF) era. METHODS: A retrospective, nonrandomized, comparative study was condu ... Full text Link to item Cite

Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults.

Journal article J Vitreoretin Dis · 2021 PURPOSE: This work assesses the intrasession repeatability of capillary perfusion density (CPD) and capillary flux index (CFI) measurements on peripapillary optical coherence tomography angiography (OCTA) in healthy eyes of older adults. METHODS: In this c ... Full text Link to item Cite

Treatment Patterns and Outcomes in Bleb-Related Endophthalmitis: A 9-Year Analysis at a Tertiary Eye Center.

Journal article J Vitreoretin Dis · 2021 PURPOSE: Clinical presentation, treatment choices, and outcomes in cases of bleb-related endophthalmitis (BRE) at a tertiary care center over a 9-year period are described. METHODS: A retrospective review was conducted of patients diagnosed with BRE at Duk ... Full text Link to item Cite

Ocular Toxocariasis Presenting as Endophthalmitis in a Young Adult Intravenous Drug User.

Journal article J Vitreoretin Dis · 2021 PURPOSE: This report describes the diagnosis of ocular toxocariasis presenting as endophthalmitis in an adult intravenous drug user. METHODS: A case is reported. RESULTS: Fundus imaging showed numerous white opacities obscuring the macula. Toxocara canis s ... Full text Link to item Cite

Association of OCT Angiography Parameters With Age in Cognitively Healthy Older Adults.

Journal article Ophthalmic Surg Lasers Imaging Retina · December 1, 2020 BACKGROUND AND OBJECTIVE: To evaluate the association of changes in retinal anatomy and microvasculature with age and sex in cognitively healthy older adults. PATIENTS AND METHODS: Cross-sectional study of cognitively healthy subjects aged 50 years and old ... Full text Link to item Cite

Clinical Decision Making and Visual Outcomes in Endophthalmitis Treated with Systemic Corticosteroids.

Journal article Ophthalmol Retina · November 2020 PURPOSE: To characterize practice patterns and compare visual outcomes in patients with endophthalmitis who did or did not receive systemic corticosteroid therapy. DESIGN: Retrospective, nonrandomized comparative trial. PARTICIPANTS: Eyes diagnosed with en ... Full text Link to item Cite

Differences in Presentation and Outcomes in Males and Females With Branch Retinal Vein Occlusion.

Journal article Ophthalmic Surg Lasers Imaging Retina · October 1, 2020 BACKGROUND AND OBJECTIVE: To investigate the effect of patient sex on presentation and outcomes of branch retinal vein occlusion (BRVO). PATIENTS AND METHODS: Retrospective chart review cohort study of 188 eyes with BRVO and cystoid macular edema (CME); 81 ... Full text Link to item Cite

A Nine-Year Analysis of Practice Patterns, Microbiologic Yield, and Clinical Outcomes in Cases of Presumed Infectious Endophthalmitis.

Journal article Ophthalmol Retina · June 2020 PURPOSE: To analyze practice patterns, microbiologic yield, and clinical outcomes in cases of presumed infectious endophthalmitis at a single tertiary academic referral center. DESIGN: Retrospective chart review. PARTICIPANTS: Eyes diagnosed with endophtha ... Full text Link to item Cite

Characteristics of Central Retinal Vein Occlusion in African Americans.

Journal article J Vitreoretin Dis · June 2020 PURPOSE: This article studies whether the characteristics and clinical course of African American patients with central retinal vein occlusion (CRVO) differ from other racial groups. METHODS: This retrospective cohort study included consecutive patients di ... Full text Link to item Cite

Sex Differences in Presentation, Treatment Patterns, and Clinical Outcomes in Central Retinal Vein Occlusion.

Journal article Ophthalmic Surg Lasers Imaging Retina · May 1, 2020 BACKGROUND AND OBJECTIVE: To evaluate the impact of sex differences on the presenting features, treatment patterns, and clinical outcomes in patients with central retinal vein occlusions (CRVO). PATIENTS AND METHODS: This retrospective, longitudinal cohort ... Full text Link to item Cite

Quiescent Neovascular Age-Related Macular Degeneration After Endophthalmitis.

Journal article J Vitreoretin Dis · 2020 PURPOSE: This article describes eyes that achieved extended remission of neovascular age-related macular degeneration (NVAMD) following acute endophthalmitis. METHODS: Adults who presented to the Duke Eye Center with acute endophthalmitis over a 9-year per ... Full text Link to item Cite

Prompt Improvement of an Enlarging Pigment Epithelial Detachment Following Intravitreal Dexamethasone in Neovascular Age-Related Macular Degeneration.

Journal article J Vitreoretin Dis · 2020 PURPOSE: This report discusses a case of neovascular age-related macular degeneration with mixed serous pigment epithelial detachment (PED) that was unresponsive to antivascular endothelial growth injections but responded to the addition of intravitreal st ... Full text Link to item Cite

Treatment Patterns and Clinical Outcomes for Central Retinal Vein Occlusion in the Antivascular Endothelial Growth Factor Era.

Journal article J Vitreoretin Dis · 2020 PURPOSE: This article describes treatment patterns and visual outcomes for central retinal vein occlusion (CRVO) in the antivascular endothelial growth factor (anti-VEGF) era. METHODS: A retrospective cohort study of eyes diagnosed with CRVO between 2009 a ... Full text Link to item Cite

Eyes With Acute, Treatment-Naïve CRVO and Foveal Intraretinal Hemorrhage: Characteristics and Outcomes.

Journal article Ophthalmic Surg Lasers Imaging Retina · December 1, 2019 BACKGROUND AND OBJECTIVE: To compare outcomes in eyes with central retinal vein occlusion (CRVO) presenting with (group 1) or without (group 2) fovea-involving intraretinal hemorrhage (IRH). PATIENTS AND METHODS: Retrospective review of patients diagnosed ... Full text Link to item Cite

Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease.

Journal article Ophthalmic Surg Lasers Imaging Retina · November 1, 2019 BACKGROUD AND OBJECTIVE: To evaluate the relationship between retinal microvascular parameters on optical coherence tomography angiography (OCTA) and neurodegenerative changes assessed by measurement of brain volume on volumetric magnetic resonance imaging ... Full text Link to item Cite

CENTRAL RETINAL VEIN OCCLUSION IN YOUNG INDIVIDUALS: A Comparison of Risk Factors and Clinical Outcomes.

Journal article Retina · October 2019 PURPOSE: To compare the presentation and outcomes of patients younger than 50 years versus patients aged 50 years and older with central retinal vein occlusion (CRVO). METHODS: This single-center retrospective study included patients with CRVO presenting b ... Full text Link to item Cite

Clinical Characteristics of Patients With CRVO in One Eye With Subsequent RVO in The Fellow Eye: A Retrospective Observational Study.

Journal article Ophthalmic Surg Lasers Imaging Retina · July 1, 2019 BACKGROUND AND OBJECTIVE: To compare risk factors in patients with a central retinal vein occlusion (CRVO) in the first eye and a subsequent retinal vein occlusion (RVO) in the fellow eye versus those with only unilateral CRVO. PATIENTS AND METHODS: Record ... Full text Link to item Cite

The Effect of Select Systemic Medications on Visual Outcomes in Diabetics With Branch Retinal Vein Occlusion

Journal article Journal of Vitreoretinal Diseases · July 1, 2019 Purpose: The purpose of this article is to evaluate the effect of systemic medications and glycemic control on the visual outcome and treatment burden in patients with diabetes and branch retinal vein occlusion (BRVO). Methods: A retrospective review was p ... Full text Cite

USE OF THE ISCHEMIC INDEX ON WIDEFIELD FLUORESCEIN ANGIOGRAPHY TO CHARACTERIZE A CENTRAL RETINAL VEIN OCCLUSION AS ISCHEMIC OR NONISCHEMIC.

Journal article Retina · June 2019 PURPOSE: To understand the relationship between baseline ischemic index (IsI) values on ultra-widefield fluorescein angiography and classification as ischemic central retinal vein occlusion (CRVO). METHODS: Single-center retrospective cohort study of CRVO ... Full text Link to item Cite

Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants.

Journal article Ophthalmol Retina · June 2019 PURPOSE: Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. DES ... Full text Link to item Cite

Association of Retinal Inner Layer Disorganization With Ultra-Widefield Fluorescein Angiographic Features and Visual Acuity in Branch Retinal Vein Occlusion.

Journal article Ophthalmic Surg Lasers Imaging Retina · June 1, 2019 BACKGROUND AND OBJECTIVE: To assess the impact of the disorganization of retinal inner layers (DRIL) on visual acuity (VA) and its correlation with ischemic index (IsI) on ultra-widefield fluorescein angiography (UWFFA) in eyes with acute, treatment-naïve ... Full text Link to item Cite

Is OCT Angiography Useful in Neurodegenerative Diseases?

Journal article Ophthalmic Surg Lasers Imaging Retina · May 1, 2019 Full text Link to item Cite

Reply.

Journal article Ophthalmol Retina · January 2019 Full text Link to item Cite

Possible Herpetic Viral Association in Cases of Acute Exudative Polymorphous Vitelliform Maculopathy

Journal article Journal of Vitreoretinal Diseases · January 1, 2019 Purpose: We describe 2 retinopathy cases with a possible herpetic association. Methods: Presentation, workup, and clinical course of 2 patients were reviewed and compiled. Results: Patients presented with no to mild symptoms and multiple bilateral fundusco ... Full text Cite

Association of Disorganization of Retinal Inner Layers with Ischemic Index and Visual Acuity in Central Retinal Vein Occlusion.

Journal article Ophthalmol Retina · November 2018 PURPOSE: To determine whether disorganization of retinal inner layers (DRIL) on optical coherence tomography (OCT) is associated with ischemia on ultra-widefield fluorescein angiography (UWFFA) and with visual outcomes in eyes with acute, treatment-naïve c ... Full text Link to item Cite

Diagnostic and Therapeutic Challenges.

Journal article Retina · September 2018 Full text Link to item Cite

Bilateral recurrent macular holes.

Journal article Am J Ophthalmol Case Rep · September 2018 PURPOSE: To report an unusual case of bilateral recurrent full-thickness macular holes (FTMH) in both eyes of a single patient over a 15-year period, with a total of 3 FTMH in the right eye and 2 in the left eye. Each FTMH was successfully treated with vit ... Full text Link to item Cite

Longitudinal Follow-Up of Choroidal Thickness in Central Retinal Vein Occlusion With and Without Cystoid Macular Edema

Journal article Journal of Vitreoretinal Diseases · September 1, 2018 Purpose: To investigate the longitudinal relationship between subfoveal choroidal thickness (CT) and central retinal vein occlusion (CRVO). Methods: Retrospective cohort of 104 subjects with enhanced-depth imaging optical coherence tomography for unilatera ... Full text Cite

Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report.

Journal article Ophthalmic Surg Lasers Imaging Retina · June 1, 2018 The authors report the optical coherence tomography angiography (OCTA)-based comparative assessment of the retinal microvasculature in a rare pair of 96-year-old female monozygotic twins discordant for Alzheimer's disease (AD). Using automated mapping of t ... Full text Link to item Cite

A Frag Bag for Efficient Removal of Dislocated Nuclear Material.

Journal article Ophthalmic Surg Lasers Imaging Retina · December 1, 2017 Dislocated nuclear material may be present in the vitreous cavity following complicated cataract surgery, closed globe injury, or spontaneous dislocation of the crystalline lens. The authors report herein a method to remove larger pieces of retained nuclea ... Full text Link to item Cite

Improvement of Recalcitrant Diabetic Macular Edema After Peritoneal Dialysis.

Journal article Ophthalmic Surg Lasers Imaging Retina · October 1, 2017 Nephropathy may be an independent and contributory risk factor for diabetic macular edema (DME). A 69-year-old man who had previously been treated with panretinal laser photocoagulation for proliferative diabetic retinopathy as well as with steroid and ant ... Full text Link to item Cite

Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab.

Journal article Ophthalmic Surg Lasers Imaging Retina · May 1, 2017 The authors report the unique response of two patients treated for cystoid macular edema (CME) secondary to central retinal vein occlusion (CRVO) who developed sequential episodes of likely sterile inflammatory responses following separate intravitreal inj ... Full text Link to item Cite

Spontaneous Closure of Full-Thickness Macular Hole With Epiretinal Membrane in Vitrectomized Eyes: Case Series and Review of Literature.

Journal article Ophthalmic Surg Lasers Imaging Retina · February 1, 2017 The authors describe three vitrectomized eyes that each subsequently developed a full-thickness macular hole (FTMH) that then spontaneously closed and summarize the current literature reporting these rare events. Clinical history, imaging, and course of th ... Full text Link to item Cite

AMBULATORY BLOOD PRESSURE PATTERNS IN PATIENTS WITH RETINAL VEIN OCCLUSION.

Journal article Retina · December 2016 PURPOSE: Failure of blood pressure (BP) to dip during sleep (nondipper pattern) is associated with cardiovascular disease and stroke. The prevalence and degree of nondipping and masked hypertension in patients with retinal vein occlusion (RVO), which is as ... Full text Link to item Cite

Bilateral Prefoveal Sub-Internal Limiting Membrane Hemorrhage in Autoimmune Hemolytic Anemia.

Journal article Ophthalmic Surg Lasers Imaging Retina · December 1, 2016 Severe anemia can cause multilayered retinal hemorrhages. A 65-year-old woman noted "red spheres" in the central vision of both eyes during a hospital admission for autoimmune hemolytic anemia. Examination revealed extensive multilayered retinal hemorrhage ... Full text Link to item Cite

Reduced Visual Acuity Following Kidney Stone Extraction.

Journal article JAMA Ophthalmol · November 1, 2016 Full text Link to item Cite

8 Questions with Dr. Moshfeghi.

Journal article Ophthalmic Surg Lasers Imaging Retina · November 1, 2016 Full text Link to item Cite

Dynamic Imaging of a Pigmented Free-Floating Vitreous Cyst.

Journal article Ophthalmic Surg Lasers Imaging Retina · October 1, 2016 The authors present an incidentally noted pigmented anterior vitreous cyst in an asymptomatic male adult. Observation was elected. Stability during the course of 2 years and mobility of the vitreous cyst using dynamic imaging are demonstrated. [Ophthalmic ... Full text Link to item Cite

Regional Changes in Choroidal Thickness in Branch Retinal Artery Occlusion.

Journal article Ophthalmic Surg Lasers Imaging Retina · September 1, 2016 BACKGROUND AND OBJECTIVE: To assess regional changes in choroidal thickness in the affected temporal hemifield of eyes with branch retinal artery occlusion (BRAO) compared to the unaffected temporal hemifield of the same eye and to fellow eyes. PATIENTS AN ... Full text Link to item Cite

Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy.

Journal article Ophthalmic Surg Lasers Imaging Retina · April 1, 2016 A 57-year-old white woman developed autoimmune retinopathy (AIR) in both eyes associated with bilateral autoimmune sensorineural hearing loss. Laboratory testing was positive for 68kDa (heat-shock protein) and 136kDa (human interstitial retinoid-binding pr ... Full text Link to item Cite

Role of aflibercept for macular edema following branch retinal vein occlusion: comparison of clinical trials.

Journal article Clin Ophthalmol · 2016 For years, the standard of care for branch-retinal-vein-occlusion-associated macular edema was initial observation followed by grid-pattern laser photocoagulation for persistent edema. Newer pharmacologic options have revolutionized the management of branc ... Full text Link to item Cite

Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema: subgroup analysis of the MEAD study.

Journal article BMC Ophthalmol · October 30, 2015 BACKGROUND: Dexamethasone intravitreal implant 0.7 mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgroup analysis of MEAD study results ... Full text Link to item Cite

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · September 2015 PURPOSE: To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective cohort study w ... Full text Link to item Cite

Retained Intraocular Perfluoro-n-octane After Valved Cannula Pars Plana Vitrectomy for Retinal Detachment.

Journal article Ophthalmic Surg Lasers Imaging Retina · April 2015 BACKGROUND AND OBJECTIVE: To investigate cases of retained intraocular perfluoro-n-octane (PFO) after pars plana vitrectomy (PPV) for retinal detachment (RD). PATIENTS AND METHODS: Retrospective, noncomparative case series of six eyes with retained intraoc ... Full text Link to item Cite

Outcomes of eyes with lesions composed of >50% blood in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Journal article Ophthalmology · February 2015 OBJECTIVE: To compare baseline characteristics, treatment frequency, visual acuity (VA), and morphologic outcomes of eyes with >50% of the lesion composed of blood (B50 group) versus all other eyes (Other group) enrolled in the Comparison of Age-Related Ma ... Full text Link to item Cite

Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial.

Journal article Lancet Neurol · January 2015 BACKGROUND: PBT2 is a metal protein-attenuating compound that might reduce metal-induced aggregation of mutant huntingtin and has prolonged survival in a mouse model of Huntington's disease. We aimed to assess the safety, tolerability, and efficacy of PBT2 ... Full text Link to item Cite

Intraocular Radio-Opaque Ring.

Journal article Ophthalmic Surg Lasers Imaging Retina · 2015 A radiologist noted a radio-opaque object in the eye of a woman undergoing X-ray examination to determine the safety of magnetic resonance imaging (MRI). Water's X-ray shows the titanium locking c-ring of a type 1 Boston keratoprosthesis. This ring was add ... Full text Link to item Cite

Comparison of optical coherence tomography assessments in the comparison of age-related macular degeneration treatments trials.

Journal article Ophthalmology · October 2014 OBJECTIVE: To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD). DESIGN: Cross-sectional st ... Full text Link to item Cite

Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema.

Journal article Ophthalmology · October 2014 PURPOSE: To evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex, DEX implant) 0.7 and 0.35 mg in the treatment of patients with diabetic macular edema (DME). DESIGN: Two randomized, multicenter, masked, sham-controlled, phase II ... Full text Link to item Cite

Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials.

Journal article JAMA Ophthalmol · August 2014 IMPORTANCE: Although anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration (AMD) results in improved vision overall, loss of substantial vision can occur. Understanding the processes that lead to loss of vision m ... Full text Link to item Cite

Neovascular events in eyes with central retinal vein occlusion undergoing serial bevacizumab or ranibizumab intravitreal injections: a retrospective review.

Journal article J Ophthalmic Vis Res · 2014 PURPOSE: To characterize the onset and type of neovascular events in eyes with central retinal vein occlusion (CRVO) undergoing serial anti-VEGF therapy. METHODS: Consecutive eyes undergoing serial intravitreal bevacizumab or ranibizumab injections for tre ... Full text Link to item Cite

Diagnostic and therapeutic challenges.

Journal article Retina · October 2013 Full text Link to item Cite

Macular morphology and visual acuity in the comparison of age-related macular degeneration treatments trials.

Journal article Ophthalmology · September 2013 OBJECTIVE: To describe the effects of treatment for 1 year with ranibizumab or bevacizumab on macular morphology and the association of macular morphology with visual acuity (VA) in eyes with neovascular age-related macular degeneration (AMD). DESIGN: Pros ... Full text Link to item Cite

Ultra-widefield imaging of Duchenne muscular dystrophy-associated proliferative retinal vasculopathy improved with panretinal laser photocoagulation alone.

Journal article Ophthalmic Surg Lasers Imaging Retina · 2013 Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder whose ophthalmic associations most commonly consist of pigmentary fundus changes and scotopic electroretinogram abnormalities. A 23-year-old man with advanced DMD and associated ca ... Full text Link to item Cite

Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results.

Journal article Ophthalmology · July 2012 OBJECTIVE: To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to as-needed treatment after 1 year of monthly treatment. DESIGN: Multicenter, randomized clinical tria ... Full text Link to item Cite

Best practices for treatment of retinal vein occlusion.

Journal article Curr Opin Ophthalmol · May 2012 Featured Work PURPOSE OF REVIEW: Retinal vein occlusion (RVO) is a sight-threatening retinal vascular disorder associated with macular edema and neovascularization. Until recently, the standard of care for branch RVO-associated macular edema was grid laser photocoagulat ... Full text Link to item Cite

Intravitreal bevacizumab for macular edema due to central retinal vein occlusion: perfused vs. ischemic and early vs. late treatment.

Journal article Curr Eye Res · December 2011 Featured Work PURPOSE/AIMS: This study investigates the efficacy of intravitreal bevacizumab (IVB) for cystoid macular edema (CME) secondary to central retinal vein occlusion (CRVO). Subgroup analysis was performed comparing early (within 90 days of CRVO onset) and late ... Full text Link to item Cite

Intravitreal bevacizumab for macular edema secondary to branch retinal vein occlusion.

Journal article Retina · October 2011 Featured Work PURPOSE: To evaluate the effect of intravitreal bevacizumab on the visual and anatomical outcome in eyes with macular edema secondary to branch retinal vein occlusion. METHODS: A retrospective, consecutive case series identified 53 consecutive patients wit ... Full text Link to item Cite

Ranibizumab and bevacizumab for neovascular age-related macular degeneration.

Journal article N Engl J Med · May 19, 2011 BACKGROUND: Clinical trials have established the efficacy of ranibizumab for the treatment of neovascular age-related macular degeneration (AMD). In addition, bevacizumab is used off-label to treat AMD, despite the absence of similar supporting data. METHO ... Full text Link to item Cite

Intravitreal bevacizumab for macular edema secondary to branch retinal vein occlusion.

Journal article Retina: the Journal of Retinal and Vitreous Diseases · 2011 Cite

Retinal vein occlusion: beyond the acute event.

Journal article Surv Ophthalmol · 2011 Retinal vein occlusion is a major cause of vision loss. We provide an overview of the clinical features, pathogenesis, natural history, and management of both branch retinal vein occlusion and central retinal vein occlusion. Several recent multicenter rand ... Full text Link to item Cite

Vision-related quality of life in persons with unilateral branch retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire.

Journal article Br J Ophthalmol · March 2010 AIM: To evaluate vision-related quality of life in persons with branch retinal vein occlusion (BRVO) using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). DESIGN: Observational, cross-sectional, interviewer-administered study ... Full text Link to item Cite

Resource use and costs of branch and central retinal vein occlusion in the elderly.

Journal article Curr Med Res Opin · January 2010 OBJECTIVE: To examine the incidence, prevalence, resource use, and costs associated with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) in elderly patients. RESEARCH DESIGN AND METHODS: In a retrospective cohort study of a n ... Full text Link to item Cite

Systemic bevacizumab leads to resolution of diabetic macular edema.

Journal article Retin Cases Brief Rep · 2010 PURPOSE: The purpose of this study is to report a case of diabetic macular edema that resolved after systemic bevacizumab. METHODS: This is an observational case report of a patient with diabetic macular edema. RESULTS: After initiation of systemic bevaciz ... Full text Link to item Cite

Embolectomy for branch retinal arterial occlusion.

Journal article Retin Cases Brief Rep · 2010 Featured Work PURPOSE: To report one surgeon's experience in treating a case of branch retinal artery occlusion with pars plana vitrectomy and surgical removal of the etiologic retinal arterial embolus. METHODS: Single case presentation of pre- and postoperative visual ... Full text Link to item Cite

Anaphylaxis following intravenous fluorescein angiography in a vitreoretinal clinic: report of 4 cases.

Journal article Can J Ophthalmol · August 2009 OBJECTIVE: To assess the incidence of anaphylaxis following intravenous fluorescein angiography (IVFA) at 1 satellite clinic. STUDY DESIGN: Observational case series. PARTICIPANTS: Records from 1400 patients were reviewed. METHODS: Consecutive vitreoretina ... Full text Link to item Cite

Pars plana vitrectomy, internal limiting membrane peeling, and panretinal endophotocoagulation for macular edema secondary to central retinal vein occlusion.

Journal article Am J Ophthalmol · April 2009 PURPOSE: To investigate the visual and anatomic outcomes in eyes with cystoid macular edema (CME) resulting from central retinal vein occlusion (CRVO) that underwent pars plana vitrectomy, internal limiting membrane peeling, and panretinal endolaser photoc ... Full text Link to item Cite

MACULAR HOLE FORMATION AND CLOSURE AFTER CATARACT EXTRACTION AND Nd:YAG CAPSULOTOMY IN A VITRECTOMIZED EYE WITH AN EPIRETINAL MEMBRANE.

Journal article Retin Cases Brief Rep · 2009 BACKGROUND: Vitreomacular traction and degeneration of the inner retinal layers of the fovea are considered contributing factors to idiopathic macular hole (MH) formation. This case report illustrates a rare scenario of MH formation and spontaneous closure ... Full text Link to item Cite

Fluocinolone acetonide sustained drug delivery device for chronic central retinal vein occlusion: 12-month results.

Journal article Am J Ophthalmol · August 2008 Featured Work PURPOSE: To determine treatment outcomes of a long-acting intravitreal fluocinolone acetonide sustained drug delivery implant in eyes with central retinal vein occlusion (CRVO) and chronic refractory macular edema. DESIGN: Prospective, noncomparative, inte ... Full text Link to item Cite

Treatment of neovascular age-related macular degeneration with intravitreal bevacizumab: efficacy of three consecutive monthly injections.

Journal article Am J Ophthalmol · July 2008 Featured Work PURPOSE: To report the efficacy of treatment of neovascular age-related macular degeneration (AMD) with intravitreal bevacizumab (Avastin; Genentech, Inc, South San Francisco, California, USA) when administered in a series of three monthly injections follo ... Full text Link to item Cite

Photodynamic therapy for predominantly hemorrhagic lesions in neovascular age-related macular degeneration.

Journal article Am J Ophthalmol · June 2008 Featured Work PURPOSE: To evaluate the response of eyes treated with photodynamic therapy (PDT) for predominantly hemorrhagic lesions in neovascular age-related macular degeneration (NVAMD). DESIGN: Consecutive, interventional case series. METHODS: A retrospective revie ... Full text Link to item Cite

A prospective study of early intraocular pressure changes after a single intravitreal triamcinolone injection.

Journal article J Glaucoma · March 2008 Featured Work PURPOSE: To prospectively monitor intraocular pressure (IOP) and gonioscopy changes within the first month after a single 4-mg intravitreal injection of triamcinolone acetonide (IVK) (Kenalog, Briston-Meyers Squibb, New York). DESIGN: Prospective comparati ... Full text Link to item Cite

Unusual case of diffuse choroidal melanoma masquerading as atypical central serous chorioretinopathy.

Journal article Retin Cases Brief Rep · 2008 PURPOSE: To describe an unusual case of diffuse circumpapillary choroidal melanoma masquerading as atypical central serous chorioretinopathy, and to describe fluorescein angiographic and optical coherence tomography characteristics of this diffuse choroida ... Full text Link to item Cite

Effect of oral pentoxifylline on cystoid macular edema associated with central retinal vein occlusion.

Journal article Retina · October 2007 Featured Work PURPOSE: To determine whether oral pentoxifylline, a xanthine-derived hemorheologic agent, decreases cystoid macular edema (CME) and improves visual acuity in eyes with a perfused central retinal vein occlusion (CRVO). METHODS: Retrospective chart review o ... Full text Link to item Cite

Large subretinal hemorrhage after intravitreal bevacizumab (Avastin) for age-related macular degeneration.

Journal article Ann Ophthalmol (Skokie) · 2007 We report the development of a large subretinal hemorrhage 4 weeks after intravitreal bevacizumab in an 84-year-old male with 20/70 visual acuity caused by occult choroidal neovascularization from neovascular age-related macular degeneration in one eye tha ... Full text Link to item Cite

Progression of choroidal neovascularization following injection of pegaptanib sodium (macugen) in two eyes with neovascular age-related macular degeneration.

Journal article Am J Ophthalmol · October 2006 PURPOSE: To describe two cases of neovascular age-related macular degeneration (AMD) that progressed despite a single intravitreal injection of pegaptanib sodium (Macugen) six weeks earlier. DESIGN: Interventional case report. METHODS: A 62-year-old man an ... Full text Link to item Cite

Retrospective review of eyes with neovascular age-related macular degeneration treated with photodynamic therapy with verteporfin and intravitreal triamcinolone.

Journal article Ann Acad Med Singap · October 2006 AIM: To review the outcomes of eyes with neovascular age-related macular degeneration (AMD) treated with photodynamic therapy (PDT) with verteporfin and intravitreal triamcinolone acetonide injection. MATERIALS AND METHODS: We retrospectively reviewed the ... Link to item Cite

Disappearance of myelinated retinal nerve fibers after pars plana vitrectomy.

Journal article Am J Ophthalmol · September 2006 PURPOSE: To describe a case of extramacular myelinated retinal nerve fibers disappearing after pars plana vitrectomy for an epiretinal membrane and macular edema. DESIGN: Interventional case report. METHODS: A 61-year-old African-American man with extramac ... Full text Link to item Cite

Recombinant tissue plasminogen activator injected into the vitreous cavity may penetrate the retinal veins of a porcine model of vascular occlusion.

Journal article Br J Ophthalmol · July 2006 Featured Work AIM: To determine if recombinant tissue plasminogen activator (rtPA) injected into the vitreous cavity can penetrate the retinal vessels of porcine eyes with or without vascular occlusion. METHODS: Eight eyes (group I) of four pigs underwent clamping of th ... Full text Link to item Cite

Central retinal vein occlusion in patients treated with long-term warfarin sodium (Coumadin) for anticoagulation.

Journal article Retina · March 2006 PURPOSE: To describe the clinical features of persons who developed central retinal vein occlusion (CVO) while being treated with Coumadin for chronic anticoagulation. METHODS: In a retrospective, comparative, noninterventional case series of patients diag ... Full text Link to item Cite

Hemi-retinal vein occlusion following LASIK.

Journal article Annals of Ophthalmology · 2006 Cite

Optical coherence tomography following photodynamic therapy with verteporfin for subfoveal predominantly classic choroidal neovascularization.

Journal article Ann Ophthalmol (Skokie) · 2006 We characterized the changes in optical coherence tomography following photodynamic therapy (PDT) for subfoveal predominantly classic choroidal neovascularization (CNV) in 26 eyes before, 1 week after, and 3 months after treatment. There appears to be a te ... Full text Link to item Cite

Photodynamic therapy and intravitreal triamcinolone for extrafoveal choroidal neovascularization in neovascular age-related macular degeneration.

Journal article Ann Ophthalmol (Skokie) · 2006 We report a case of extrafoveal choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration treated with photodynamic therapy (PDT) and intravitreal triamcinolone. Nine months following PDT and intravitreal triamcinolone, n ... Full text Link to item Cite

Hemi-retinal vein occlusion following LASIK.

Journal article Ann Ophthalmol (Skokie) · 2006 Featured Work We report a case of hemi-retinal vein occlusion following laser-assisted in situ keratomileusis (LASIK) in a healthy 46-year-old Caucasian male. A hemi-retinal vein occlusion following LASIK could be coincidental. However, young age, absence of risk factor ... Full text Link to item Cite

Intravitreal triamcinolone for cystoid macular edema related to branch retinal vein occlusion.

Journal article Ann Ophthalmol (Skokie) · 2006 We retrospectively evaluated the effectiveness of intravitreal triamcinolone in treating 19 eyes with macular edema related to branch retinal vein occlusion (BRVO). Eyes with nonischemic BRVO respond more favorably than those with ischemic BRVO. A single i ... Full text Link to item Cite

Group 2A idiopathic juxtafoveolar retinal telangiectasia in monozygotic twins.

Journal article Am J Ophthalmol · March 2005 PURPOSE: To report the clinical and fluorescein angiographic characteristics of monozygotic twins affected by group 2A idiopathic juxtafoveolar retinal telangiectasia. DESIGN: Observational case report. METHODS: Both eyes of identical twins were examined i ... Full text Link to item Cite

Functional changes after photodynamic therapy with verteporfin.

Journal article Am J Ophthalmol · January 2005 OBJECTIVE: To investigate image preferences after photodynamic therapy (PDT). DESIGN: Prospective, cross-sectional study. METHODS: Seventeen patients with neovascular age-related macular degeneration were tested by color vision, contrast sensitivity, and n ... Full text Link to item Cite

Radial optic neurotomy in the porcine eye without retinal vein occlusion.

Journal article Arch Ophthalmol · August 2004 OBJECTIVE: To demonstrate the histopathologic changes in the porcine eye without retinal vein occlusion after radial optic neurotomy (RON). METHODS: A RON was performed in 14 normal eyes of 12 Yorkshire Cross pigs. One radial stab incision at the edge of t ... Full text Link to item Cite

Radial optic neurotomy as treatment for central retinal vein occlusion

Journal article American Journal of Ophthalmology · June 2004 Full text Cite

Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease.

Journal article Am J Ophthalmol · December 2003 PURPOSE: To assess the role of plasma total homocysteine (tHcy) levels, serum folate and vitamin B(12)levels, and homozygosity for the thermolabile methylenetetrahydrofolate reductase genotype (TT) as risk factors for retinal vascular occlusive disease. DE ... Full text Link to item Cite

A phase III, multicenter, randomized, placebo-controlled clinical trial of topical aminocaproic acid (Caprogel) in the management of traumatic hyphema.

Journal article Ophthalmology · November 2003 OBJECTIVE: To determine the safety and efficacy of topical aminocaproic acid (Caprogel) in the management of traumatic hyphema. DESIGN: Multicenter, randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: A total of 51 patients particip ... Full text Link to item Cite

The effect of arteriovenous sheathotomy on cystoid macular oedema secondary to branch retinal vein occlusion.

Journal article Br J Ophthalmol · November 2003 BACKGROUND: Arteriovenous (AV) sheathotomy, a potential treatment for branch retinal vein occlusion (BVO), surgically separates retinal vessels at an AV crossing. Relief of the aetiological obstruction, with resolution of cystoid macular oedema (CMO), may ... Full text Link to item Cite

Radial optic neurotomy as treatment for central retinal vein occlusion.

Journal article Am J Ophthalmol · November 2003 PURPOSE: To review our initial experience with radial optic neurotomy as treatment for retinal vein occlusion. DESIGN: Interventional case series. PATIENT POPULATION: five patients (four with central retinal vein occlusion and one with hemiretinal vein occ ... Full text Link to item Cite

Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion.

Journal article Am J Ophthalmol · September 2003 PURPOSE: To evaluate treatment of cystoid macular edema associated with central retinal vein occlusion with intravitreal triamcinolone acetonide. METHODS: This study included 10 eyes of nine patients with perfused central retinal vein occlusion with visual ... Full text Link to item Cite

Vision-related quality of life in people with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire.

Journal article Arch Ophthalmol · September 2003 Featured Work OBJECTIVE: To study visual function and vision-related quality of life in persons with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). METHODS: Interviewer-administered study of persons with c ... Full text Link to item Cite

Intraoperative ketorolac and eye pain after viteoretinal surgery: a prospective, randomized, placebo-controlled study.

Journal article Retina · February 2003 PURPOSE: To compare the efficacy of one intraoperative dose of intravenous ketorolac tromethamine to saline placebo in controlling postoperative eye pain, nausea, and sedation following vitreoretinal surgery. STUDY DESIGN: Prospective, randomized, placebo- ... Full text Link to item Cite

Optimal laser power to rupture Bruch's membrane and the retinal vein in the pig.

Journal article Ophthalmic Surg Lasers Imaging · 2003 BACKGROUND AND OBJECTIVE: For laser-induced chorioretinal venous anastomosis to become a viable treatment option for perfused central retinal vein occlusion, laser parameters must be refined to more reliably create venous anastomoses while minimizing compl ... Link to item Cite

Intravitreal tissue plasminogen activator for the treatment of central retinal vein occlusion.

Journal article Ophthalmic Surg Lasers Imaging · 2003 A 58-year-old hypertensive man with a perfused central retinal vein occlusion of 21 days' duration received 50 microg of intravitreal recombinant tissue plasminogen activator in 0.1 cc. Best-corrected visual acuity improved 2 weeks after the injection. Opt ... Link to item Cite

Arteriovenous sheathotomy for branch retinal vein occlusion.

Journal article Ophthalmol Clin North Am · December 2002 Branch vein occlusion is a significant cause of visual loss attributed to retinal vascular disease and is second only to diabetic retinopathy. BVO nearly always occurs at an AV crossing because of compression of the vein by the artery, resulting in hemodyn ... Full text Link to item Cite

Adverse reaction characterized by chest pain, shortness of breath, and syncope associated with verteporfin (visudyne).

Journal article Am J Ophthalmol · August 2002 PURPOSE: To report a serious adverse reaction associated with verteporfin infusion. DESIGN: Observational case report. METHODS: Case report of a single individual undergoing photodynamic therapy (PDT) with verteporfin. RESULTS: A 77-year-old man with long- ... Full text Link to item Cite

Vitrase ISTA Pharmaceuticals.

Journal article IDrugs · April 2002 Vitrase is under development by ISTA Pharmaceuticals Inc (formerly Advanced Corneal Systems, ACS) and Otsuka Pharmaceutical (in Japan) for the potential treatment of vitreous hemorrhage and diabetic retinopathy. In November 1998, it was approved in Mexico ... Link to item Cite

Intraoperative choroidal hemorrhage in the Osler-Rendu-Weber syndrome.

Journal article Am J Ophthalmol · February 2002 PURPOSE: To describe a patient with Osler-Rendu-Weber syndrome who developed a nonsimultaneous intraoperative choroidal hemorrhage in each eye. METHOD: Interventional case report. A 65-year-old Caucasian woman with Osler-Rendu-Weber syndrome developed a ch ... Full text Link to item Cite

Hypotony caused by scleral buckle erosion in Marfan syndrome.

Journal article Am J Ophthalmol · September 2001 PURPOSE: To describe hypotony caused by erosion of the conjunctiva and sclera by a silicone scleral buckle. METHODS: Interventional case report. A 33-year-old man with Marfan syndrome presented with hypotony maculopathy and a collapsed globe 17 months afte ... Full text Link to item Cite

Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration.

Journal article Am J Ophthalmol · February 2001 PURPOSE: To evaluate a new procedure for displacement of large, thick submacular hemorrhage in patients with age-related macular degeneration. METHODS: Retrospective review of 11 eyes of 11 patients with age-related macular degeneration and thick submacula ... Full text Link to item Cite

Clinicopathologic findings in eyes with retained perfluoro-n-octane liquid.

Journal article Ophthalmology · January 2001 OBJECTIVE: To describe the clinical and histopathologic findings in five eyes with retained perfluoro-n-octane (PFO) liquid after retinal reattachment surgery. DESIGN: Retrospective, noncomparative, clinicopathologic case series. PARTICIPANTS: Surgical spe ... Full text Link to item Cite

Traumatic hyphema in children: risk factors for complications.

Journal article Arch Ophthalmol · January 2001 OBJECTIVE: To identify risk factors associated with higher rates of ocular complications in children with traumatic hyphema. METHODS: Consecutive inpatient records from July 1990 through December 1997 were retrospectively reviewed for all children (aged < ... Link to item Cite

Eye pain after vitreoretinal surgery: a prospective study of 185 patients.

Journal article Retina · 2001 PURPOSE: To assess subjective levels of eye pain, nausea, and sedation following vitreoretinal surgery performed with intravenous sedation and retrobulbar anesthesia. METHODS: One hundred eighty-five consecutive patients who underwent vitreoretinal surgery ... Full text Link to item Cite

Pars planitis: clinical features and class II HLA associations.

Journal article Ophthalmology · March 1999 OBJECTIVE: To describe a cohort of patients with pars planitis followed at a single tertiary care institution, determine the frequency of multiple sclerosis and/or optic neuritis in patients with this disorder, and calculate gene frequencies of human leuko ... Full text Link to item Cite

Chorioretinal venous anastomosis for central retinal vein occlusion: transvitreal venipuncture.

Journal article Ophthalmic Surg Lasers · January 1999 Featured Work The authors describe an eye with a central retinal vein occlusion that developed chorioretinal anastomoses following transvitreal venipuncture, a vitreoretinal surgical technique. ... Link to item Cite

Current concepts in the management of central retinal vein occlusion.

Journal article Curr Opin Ophthalmol · June 1998 The results of the Central Vein Occlusion Study guide the management of complications of macular edema and neovascularization. Panretinal photocoagulation was shown to be beneficial for eyes with at least 2 hours of iris neovascularization or any angle neo ... Full text Link to item Cite

Laser-induced chorioretinal venous anastomosis for nonischemic central or branch retinal vein occlusion.

Journal article Arch Ophthalmol · January 1998 OBJECTIVE: To establish a communication between an obstructed retinal vein and the choroid by means of laser in eyes with nonischemic central or branch vein occlusion. METHODS: Retrospective review identified eyes with nonischemic central or branch vein oc ... Full text Link to item Cite

White dot fovea in an African American patient.

Journal article Arch Ophthalmol · January 1998 Full text Link to item Cite

Eye injuries associated with paintball guns.

Journal article Int Ophthalmol · 1998 AIMS: This study identifies the various types of ocular injuries sustained after blunt trauma with a paintball fired from a paintball gun. METHODS: We report two patients who sustained injury to an eye after being shot with a paintball and review similar c ... Full text Link to item Cite

Current concepts in the management of central retinal vein occlusion.

Journal article Curr Opin Ophthalmol · June 1997 The results of the Central Vein Occlusion Study (CVOS) guide the management of macular edema and neovascularization. This study did not show that grid-pattern laser photocoagulation had a significant beneficial effect for the management of decreased visual ... Full text Link to item Cite

Are antioxidants or other supplements protective for age-related macular degeneration?

Journal article Curr Opin Ophthalmol · June 1996 As the number of individuals with age-related macular degeneration increases, the economic and social consequences of this blinding disease rise. No proven preventive measures exist to halt development or progression of this disease. The specific insults t ... Full text Link to item Cite

Hyalocytes synthesize and secrete inhibitors of retinal pigment epithelial cell proliferation in vitro.

Journal article Arch Ophthalmol · June 1996 BACKGROUND: Retinal pigment epithelial (RPE) cells that enter the vitreous in pathologic conditions, such as retinal detachment, may proliferate and contribute to the formation of epiretinal membranes. OBJECTIVE: To study whether hyalocytes, endogenous vit ... Full text Link to item Cite

Natural history of subfoveal subretinal hemorrhage in age-related macular degeneration.

Journal article Retina · 1996 PURPOSE: The authors describe the natural history of subfoveal subretinal hemorrhage (for which laser treatment was not indicated) in age-related macular degeneration. METHODS: A retrospective review of data was performed at a tertiary retinal referral cen ... Full text Link to item Cite

The effect of oral 13-cis-retinoic acid on retinal redetachment after surgical repair in eyes with proliferative vitreoretinopathy.

Journal article Ophthalmology · March 1995 PURPOSE: To determine if postoperative oral 13-cis-retinoic acid alters the rate of recurrent retinal detachment in eyes undergoing surgery for proliferative vitreoretinopathy (PVR). METHODS: Twenty eyes of 20 adult patients with a detachment due to PVR we ... Full text Link to item Cite

Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis.

Journal article Cornea · March 1995 We describe a case of Candida parapsilosis endophthalmitis with a consecutive keratitis after phacoemulsification and posterior chamber intraocular lens implantation in an otherwise healthy eye. Despite aggressive medical and surgical management during a 2 ... Link to item Cite

Clinicopathologic correlation of an epiretinal membrane associated with a recurrent macular hole.

Journal article Retina · 1995 PURPOSE: To describe the clinicopathologic features of an epiretinal membrane associated with a recurrent, full-thickness idiopathic macular hole and speculate on the mechanism(s) contributing to its recurrence 1 year after initially successful closure of ... Full text Link to item Cite

Alveolar rhabdomyosarcoma that metastasized to the orbit.

Journal article Arch Ophthalmol · December 1993 A 22-year-old woman with a history of hyperthyroidism and a paravaginal alveolar rhabdomyosarcoma developed diplopia 3 months after successful autologous bone marrow transplantation. Results of computed tomographic scan showed apparent enlargement of the r ... Full text Link to item Cite

A direct correlation of the resolution of pseudophakic cystoid macular edema with acetazolamide therapy.

Journal article Ann Ophthalmol · April 1991 We report the case of a patient with pseudophakic cystoid macular edema whose visual acuity improved promptly with oral administration of 500 mg of acetazolamide extended-release capsules BID for two weeks. However, vision worsened again within two weeks o ... Link to item Cite

Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs

Journal article Drug Development Research · January 1, 1991 The uveal tract of the eye, which consists of the iris, ciliary body, and choroid, is responsible for the primary nutritional supply of the ocular structures, especially the retina and, through the production of aqueous and vitreous humors, for nourishment ... Full text Cite

An unusual necrotizing dermatitis after a single application of topical benzoin and pressure bandage for enucleation of an eye.

Journal article Lens Eye Toxic Res · 1990 We report on a patient who developed necrotizing contact dermatitis after a single topical application of tincture of benzoin and a pressure bandage following enucleation of an eye. The toxicity manifested in this case was more severe than any documented p ... Link to item Cite

Age-related macular degeneration.

Journal article Surv Ophthalmol · 1988 Age-related macular degeneration (AMD) is the leading cause of irreversible severe visual loss in the United States in people over 50 years of age. The nonexudative stage includes hard drusen (associated with localized dysfunction of the retinal pigment ep ... Full text Link to item Cite

CENTRAL RETINAL VEIN OCCLUSION IN GATA2 DEFICIENCY.

Journal article Retin Cases Brief Rep PURPOSE: To examine the association between GATA2 deficiency-related myelodysplastic syndrome (MDS) and central retinal vein occlusion (CRVO). METHODS: Clinical ophthalmologic examination and laboratory work-up was performed for a patient with GATA2 defici ... Full text Link to item Cite