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David Fitzpatrick

James B. Duke Distinguished Professor Emeritus of Medicine
Neurobiology
Box 3209 Med Ctr, Durham, NC 27710
427C Bryan Res Bldg, Durham, NC 27710

Featured Works


A morphological basis for orientation tuning in primary visual cortex.

Journal article Nat Neurosci · August 2004 Featured Publication Feedforward connections are thought to be important in the generation of orientation-selective responses in visual cortex by establishing a bias in the sampling of information from regions of visual space that lie along a neuron's axis of preferred orienta ... Full text Link to item Cite

Mapping multiple features in the population response of visual cortex.

Journal article Nature · June 26, 2003 Featured Publication Stimulus features such as edge orientation, motion direction and spatial frequency are thought to be encoded in the primary visual cortex by overlapping feature maps arranged so that the location of neurons activated by a particular combination of stimulus ... Full text Link to item Cite

Emergent properties of layer 2/3 neurons reflect the collinear arrangement of horizontal connections in tree shrew visual cortex.

Journal article J Neurosci · April 1, 2003 Featured Publication The superficial layers of primary visual cortex, unlike layer 4, have an extensive network of long-range horizontal connections linking sites of similar orientation preference. To identify possible functional consequences of this distinct anatomy, we compa ... Full text Link to item Cite

Spatial coding of position and orientation in primary visual cortex.

Journal article Nat Neurosci · September 2002 Featured Publication We examined the spatial distribution of population activity in primary visual cortex (V1) of tree shrews with optical imaging and electrophysiology. A line stimulus, thinner than the average V1 receptive field, evoked a broad strip of neural activity of ne ... Full text Link to item Cite

The contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortex.

Journal article Nature · June 28, 2001 Featured Publication Sensory experience begins when neural circuits in the cerebral cortex are still immature; however, the contribution of experience to cortical maturation remains unclear. In the visual cortex, the selectivity of neurons for oriented stimuli at the time of e ... Full text Link to item Cite

Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex.

Journal article J Neurosci · March 15, 1997 Featured Publication Horizontal connections, formed primarily by the axon collaterals of pyramidal neurons in layer 2/3 of visual cortex, extend for millimeters parallel to the cortical surface and form patchy terminations. Previous studies have provided evidence that the patc ... Full text Link to item Cite

A systematic map of direction preference in primary visual cortex.

Journal article Nature · February 22, 1996 Featured Publication Neurons in the primary visual cortex respond selectively to the orientation of edges and their direction of motion. Orientation preference is mapped in a systematic fashion across the cortical surface, such that neurons in adjacent columns have similar but ... Full text Link to item Cite