Overview
My research focuses on the contributions of lactogenic and somatogenic signaling on fetal and perinatal growth. We have developed a novel double mutant mouse model that displays many of the features of the metabolic syndrome. The double mutant mice. which are growth hormone deficient and lactogen resistant, demonstrate growth failure, hypoinsulinemia, insulin hyper-sensitivity, and hypoglycemia at one week of age, but develop obesity, insulin resistance, and glucose intolerance by 6-9 months of age.
Prolactin, placental lactogen, growth hormone, STAT5, IGF-I, IGF-II, transcription factors, adipogenesis
Prolactin, placental lactogen, growth hormone, STAT5, IGF-I, IGF-II, transcription factors, adipogenesis
Current Appointments & Affiliations
Research Scientist, Senior
Pharmacology & Cancer Biology,
Basic Science Departments
Education, Training & Certifications
Emory University ·
1987
Ph.D.