Francis Ali-Osman

Margaret Harris and David Silverman Professor Emeritus of Neuro-Oncology Research

Neurosurgery, Neuro-Oncology

francis.aliosman@duke.edu

Box 3156 Med Ctr, Durham, NC 27710

199 Medical Science Research B, Durham, NC 27710

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Academic Experience
1. Current Duke Appointments & Affiliations
2. Previous Duke Appointments & Affiliations

Global Scholarship

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Research
1. Selected Grants

Scholarly Works

Teaching & Mentoring

Recognition

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Scholarly Works - Conferences

A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit-positive Acute Myeloid Leukemia.

Conference Clin Lymphoma Myeloma Leuk · February 2021 INTRODUCTION: Adults with acute myeloid leukemia (AML) have a high rate of remission; however, more than 50% relapse. C-kit is expressed in approximately 60% of patients with de novo AML and represents a potential therapeutic target. MATERIALS AND METHODS: ... Full text Link to item Cite

EPID-12. DEMOGRAPHICS AND LIFESTYLE FACTORS IN GLIOMA RISK: A REPORT FROM THE GLIOMA INTERNATIONAL CASE-CONTROL STUDY

Conference Neuro-Oncology · November 1, 2016 Full text Cite

Long-Term Follow-up Results: A Phase 2 Trial of Imatinib Mesylate As Maintenance Therapy for Patients with Newly Diagnosed c-Kit Positive Acute Myeloid Leukemia (AML)

Conference BLOOD · December 3, 2015 Link to item Cite

Termination of BRAF Targeted Therapy Augments Tumor Growth in the Setting of Vemurafenib Resistance

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2013 Link to item Cite

ADRENOMEDULLIN (ADM) LEVELS IN BONCHOALVEOLAR LAVAGE (BAL) PREDICT VENTILATOR ASSOCIATED PNEUMONIA (VAP) IN PATIENTS WITH A HIGH CLINICAL PULMONARY INFECTION SCORE (CPIS)

Conference CRITICAL CARE MEDICINE · December 2012 Link to item Cite

The mutational status of the p53 tumor suppressor gene is a determinant of GSTP1 expression and mediates GSTP1-dependent drug resistance in human glioblastoma

Conference CANCER RESEARCH · April 15, 2012 Full text Link to item Cite

GAIN-OF-FUNCTION tGLI1 TRANSCRIPTION FACTOR AUGMENTS ANCHORAGE-INDEPENDENT GROWTH OF MEDULLOBLASTOMA CELLS AND CONFERS THEIR RESISTANCE TO SMO INHIBITORS

Conference NEURO-ONCOLOGY · May 1, 2011 Link to item Cite

UPREGULATION OF VEGF-A GENE EXPRESSION BY THE tGLI1 TRANSCRIPTION FACTOR CONTRIBUTES TO GLIOBLASTOMA ANGIOGENESIS

Conference NEURO-ONCOLOGY · May 1, 2011 Link to item Cite

EGFR AND EGFRvIII UNDERGO STRESS- AND EGFR KINASE INHIBITOR-INDUCED MITOCHONDRIAL TRANSLOCALIZATION IN GLIOBLASTOMA: A POTENTIAL MECHANISM OF EGFR- AND EGFRvIII-DRIVEN ANTAGONISM OF APOPTOSIS AND DRUG RESPONSE

Conference NEURO-ONCOLOGY · May 1, 2011 Link to item Cite

UNDERSTANDING AND TARGETING KINASE-INDEPENDENT ACTIVITY OF EGFR AND EGFRVIII TO OVERCOME GBM DRUG RESISTANCE

Conference NEURO-ONCOLOGY · November 1, 2010 Link to item Cite

GENETIC DIVERSITY ASSOCIATED WITH SURVIVAL IN MALIGNANT GLIOMAS IDENTIFIED BY LINKAGE DISEQUILIBRIUM-BASED ANALYSIS OF HAPLOTYPE BLOCK REGIONS OF DNA REPAIR GENES

Conference NEURO-ONCOLOGY · December 1, 2009 Link to item Cite

DIRECT TYROSINE PHOSPHORYLATION OF GSTP1 BY EGFR INDUCES JNK ACTIVATION IN GLIOBLASTOMA CELLS

Conference NEURO-ONCOLOGY · December 1, 2009 Link to item Cite

IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN GSTP1 GENE AS A NOVEL TRANSCRIPTIONAL TARGET OF THE P53 TUMOR SUPPRESSOR GENE

Conference NEURO-ONCOLOGY · October 1, 2008 Link to item Cite

LIGAND-DEPENDENT ACTIVATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INDUCES EARLY DRUG RESISTANCE IN BRAIN TUMOR CELLS VIA ACTIVATION OF ITS DOWNSTREAM TARGET GLUTATHIONE S-TRANSFERASE P1

Conference NEURO-ONCOLOGY · October 1, 2008 Link to item Cite

CONSTITUTIVE STAT3 ACTIVATION FREQUENTLY COEXISTS WITH EGFR EXPRESSION IN HIGH-GRADE GLIOMAS AND TARGETING STAT3 SENSITIZES THEM TO ANTI-EGFR AND ALKYLATING AGENTS

Conference NEURO-ONCOLOGY · October 1, 2008 Link to item Cite

Stat3 constitutive activation is associated with glioma tumor grade: Pathway profiling and therapy

Conference NEURO-ONCOLOGY · October 1, 2007 Link to item Cite

Targeting constitutively activated stat3 sensitizes medulloblastomas to chemotherapeutic agents

Conference NEURO-ONCOLOGY · October 1, 2007 Link to item Cite

Targeting hedgehog signaling in medulloblastoma

Conference NEURO-ONCOLOGY · October 1, 2007 Link to item Cite

Polymorphism of the promoter of the epidermal growth factor (EGF) gene in patients, its distribution and correlation with survival in glioma patients

Conference NEURO-ONCOLOGY · October 1, 2006 Link to item Cite

Glutathione S-transferase P1 (GSTP1) is a novel downstream target of Akt in human gliomas

Conference NEURO-ONCOLOGY · October 1, 2006 Link to item Cite

Role of BAY 43-9006 in combination with temozolomide and melphalan in metastatic melanoma

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2006 Link to item Cite

Multimodal dose dense therapy for mantle cell lymphoma.

Conference BLOOD · November 16, 2005 Link to item Cite

Glutathione S-transferase as a marker of metastatic potential in malignant melanoma

Conference Journal of the American College of Surgeons · September 2005 Full text Cite

A novel mechanism of PKA- and PKC-dependent drug resistance in human gliomas involving phosphorylation and metabolic activation of glutathione S-transferase P1 (GSTP1)

Conference NEURO-ONCOLOGY · July 1, 2005 Link to item Cite

Prevalence and prognostic significance of polymorphisms at the glutathione S-transferase M1, M3, P1, and T1 gene loci in human astrocytomas

Conference NEURO-ONCOLOGY · July 1, 2005 Link to item Cite

Pharmacogenetics of the human glutathione S-transferase P1 gene and tumor response to chemotherapy

Conference EUROPEAN JOURNAL OF CANCER · November 2002 Link to item Cite

A high throughput fluorescent assay for the detection of glutathione S-transferase polymorphic alleles

Conference AMERICAN JOURNAL OF HUMAN GENETICS · October 2002 Link to item Cite