Francis Joseph Miller Jr.

Adjunct Professor in the Department of Medicine

Medicine, Cardiology

203 Research Drive, 397 MSRB1, Durham, NC 27705

https://orcid.org/0000-0001-5822-0549

508 Fulton St, Bldg 15, Room 306, Durham, NC 27705

More About This Person

At a Glance

Credentials
1. Education
2. Licensure

Academic Experience

Global Scholarship

Keywords

Research

Scholarly Works

Teaching & Mentoring
1. Advising & Mentoring Summary

Recognition
1. Academic Honors

Professional Activities

Scholarly Works - Conferences

Redox-regulation of NADPH Oxidase 4 in Cardiovascular Disease

Conference Free Radical Biology and Medicine · December 2019 Full text Cite

Nadph Oxidase Nox1-dependent Endocytosis and Activation is Regulated by a Conserved Trafficking Motif in Vascular Smooth Muscle Cells

Conference CIRCULATION RESEARCH · August 2, 2019 Link to item Cite

Transcriptional Activation of Nox1 NADPH Oxidase by Protein Disulfide Isomerase in Chronic Inflammation

Conference ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY · May 2019 Link to item Cite

Inhalation of an RNA Aptamer Targeting Extracellular Histones Protects from Acute Lung Injury

Conference MOLECULAR THERAPY · April 22, 2019 Link to item Cite

Effect of Circulating EGF-like Ligands on NADPH Oxidase Expression in Vascular Cells

Conference FASEB JOURNAL · April 2019 Link to item Cite

Expression of Nox4 NADPH Oxidase Splice Variants Generate Hydrogen Peroxide and Modify the Cell Cycle

Conference FASEB JOURNAL · April 2019 Link to item Cite

Smooth Muscle Cell MicroRNA-9 is Transcriptionally Regulated by MicroRNA-25 in Vascular Disease

Conference FASEB JOURNAL · April 2019 Link to item Cite

Alternative splicing of Nox4 regulates subcellular redox-dependent pathways in vascular smooth muscle cells

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

VSMC Specific Aptamer Ligands for the Next Generation of DES to Prevent Neointimal Formation

Conference MOLECULAR THERAPY · May 1, 2018 Link to item Cite

Rna Inhibitors of Nuclear Proteins Implicated in Multiple Organ Dysfunction Syndrome

Conference MOLECULAR THERAPY · May 2018 Link to item Cite

Inhibition of Extracellular Histones in Sepsis-Induced Cardiovascular Function

Conference MOLECULAR THERAPY · May 2018 Link to item Cite

The Regulation Of Nox In Vascular Disease

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

Abstract 172: Vascular Smooth Muscle Cell Activation is Regulated by miR25 Induced miR-9 Suppression of Nox4 and Myocardin

Conference CIRCULATION RESEARCH · July 21, 2017 Link to item Cite

Treatment of Sepsis by Neutralization of Extracellular Histones with Nucleic Acid Aptamers

Conference MOLECULAR THERAPY · May 1, 2017 Link to item Cite

LncRNA MANTIS facilitates endothelial angiogenic function

Conference ACTA PHYSIOLOGICA · March 1, 2017 Link to item Cite

Circulating EGF-Like Ligands in Obesity Increase Neointimal Formation through Upregulation of NADPH Oxidase 1

Conference Free Radical Biology and Medicine · November 2016 Full text Cite

61. Vascular Smooth Muscle Cell RNA Aptamers for the Treatment of Cardiovascular Disease

Conference Molecular Therapy · May 2015 Full text Cite

Cell-Targeted RNA-Based Therapies for Cardiovascular Disease

Conference MOLECULAR THERAPY · May 1, 2014 Link to item Cite

EGF-Like Ligands Contribute to Neointimal Formation via Nox1-Mediated SMC Growth

Conference CIRCULATION · November 26, 2013 Link to item Cite

Smooth Muscle Cell Targeted RNA Aptamers for the Treatment of Vascular Disease

Conference MOLECULAR THERAPY · June 1, 2013 Link to item Cite

Nox1 NADPH Oxidase is Necessary for Late, but not Early, Ischemic Preconditioning against Myocardial Infarction in Mice

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

Nox1 Phosphorylation in Cardiovascular Disease

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

Aptamer-siRNA Chimera Inhibitors of Intimal Hyperplasia

Conference MOLECULAR THERAPY · May 1, 2012 Link to item Cite

Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells

Conference Free Radical Biology and Medicine · 2010 Full text Cite

The Majority of Nox1 Resides at Internal Membranes and Traffics Differentially with Stimulation

Conference Free Radical Biology and Medicine · 2010 Full text Cite

EGF-like Ligands Modulate NADPH Oxidase Expression and Activity in a Primate Model of Atherosclerosis

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Nox4 NADPH Oxidase Modulates the Intracellular Redox State

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Potential Role of Protein Kinase C-beta I as a Novel Regulator of Nox1 Activation

Conference FREE RADICAL BIOLOGY AND MEDICINE · 2009 Link to item Cite

Nox1-derived reactive oxygen species (ROS) mediate thrombin-induced influx of calcium in vascular smooth muscle cells (SMC)

Conference FASEB JOURNAL · April 2008 Link to item Cite

Oxidized extracellular redox state increases Nox1 expression in vascular smooth muscle cells

Conference FASEB JOURNAL · April 2008 Link to item Cite

Nox1-mediated EGFR transactivation increases N-cadherin shedding and smooth muscle migration

Conference FASEB JOURNAL · April 2008 Link to item Cite

PATHOLOGICAL ROLE OF Nox PROTEINS

Conference FREE RADICAL BIOLOGY AND MEDICINE · 2008 Link to item Cite

Effect of oxidative stress on apoptosis and regulation of Bax and Bel-xL in development of intimal thickening of balloon-injured rat carotid artery

Conference FASEB JOURNAL · April 1, 2007 Link to item Cite

Increased Plasma oxidized Phospholipid : Apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions following dietary lipid lowering: A potential biomarker of early atherosclerosis regression

Conference CIRCULATION · October 31, 2006 Link to item Cite

Secretion of cyclophilin A by glutathione peroxidase-1 deficient smooth muscle cells has a paracrine effect on normal smooth muscle cells to activate NF-kB and increase cell growth

Conference CIRCULATION · October 31, 2006 Link to item Cite

Nox1 is required for smooth muscle cell activation of matrix-metalloproteinase-9 and cell migration in response to thrombin

Conference CIRCULATION · October 31, 2006 Link to item Cite

Superoxide mediates the medial smooth muscle cell apoptosis associated with vascular injury

Conference FASEB JOURNAL · March 7, 2006 Link to item Cite

CIC-3 is required for normal NF-kappa B activation by inflammatory mediators in vascular smooth muscle (VSM)

Conference FASEB JOURNAL · March 7, 2006 Link to item Cite

Early gestation dexamethasone-exposure programs tissue-specific alterations in reactive oxygen species production

Conference PEDIATRIC RESEARCH · November 1, 2005 Link to item Cite

Role of p47(phox) in angiotensin II-induced abdominal aortic aneurysm formation in ApoE knock-out mice

Conference CIRCULATION · October 25, 2005 Link to item Cite

Altered prostaglandin production in the fetal programming of ovine coronary artery vascular reactivity

Conference FASEB JOURNAL · March 4, 2005 Link to item Cite

Role of the NADPH oxidase subunit Nox4 in generation of reactive oxygen species and growth arrest of vascular smooth muscle cells in atherosclerosis.

Conference JOURNAL OF INVESTIGATIVE MEDICINE · March 1, 2005 Link to item Cite

Nox4-derived reactive oxygen species and growth arrest of vascular smooth muscle cells in atherosclerosis

Conference CIRCULATION · October 26, 2004 Link to item Cite

Dual role of antioxidant-1 in modulating the activity and expression of extracellular superoxide dismutase

Conference CIRCULATION · October 26, 2004 Link to item Cite

Early Gestation Dexamethasone Exposure Alters Coronary Artery Reactivity in Newborn Lambs.

Conference Pediatric Research · October 2004 Full text Cite

Coronary Artery NAD(P)H oxidase expression and superoxide anion production is enhanced by early gestation glucocorticoid exposure

Conference PEDIATRIC RESEARCH · April 1, 2004 Link to item Cite

Early gestation glucocorticoid exposure enhances postnatal coronary artery vasoconstriction

Conference PEDIATRIC RESEARCH · April 1, 2004 Link to item Cite

Hypertension, vasomotor dysfunction and oxidative stress in ClC-3 deficient mice

Conference FASEB JOURNAL · March 24, 2004 Link to item Cite

Early gestation dexamethasone exposure programs coronary artery dysfunction

Conference FASEB JOURNAL · March 23, 2004 Link to item Cite

The differential role of superoxide and hydrogen peroxide in atherosclerosis

Conference FASEB JOURNAL · March 23, 2004 Link to item Cite