Charles Franklin Starmer

Journal article J Membr Biol · September 2005 Featured Publication Voltage- and/or conformation-dependent association and dissociation of local anesthetic-class drugs from a putative receptor site in domain IV S6 of the sodium channel and slow conformation transitions of the drug-associated channel have been proposed as m ... Full text Link to item Cite

What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels.

Journal article Cardiovasc Res · January 2003 Featured Publication OBJECTIVE: The vulnerable period (VP) defines an interval during which premature impulses can trigger reentrant arrhythmias leading to ventricular fibrillation and sudden death. The mechanistic basis of the success or failure of impulse propagation during ... Full text Link to item Cite

Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias.

Journal article Circulation · August 1, 1995 Featured Publication BACKGROUND: Prompted by the results of CAST results, attention has shifted from class I agents that primarily block sodium channels to class III agents that primarily block potassium channels for pharmacological management of certain cardiac arrhythmias. R ... Full text Link to item Cite

Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation.

Journal article Biophysical journal · November 1993 Featured Publication Cardiac tissue can display unusual responses to certain stimulation protocols. In the wake of a conditioning wave of excitation, spiral waves can be initiated by applying stimuli timed to occur during a period of vulnerability (VP). Although vulnerability ... Full text Cite

Cardiac instability amplified by use-dependent Na channel blockade.

Journal article Am J Physiol · April 1992 Featured Publication Drugs that exhibit use-dependent Na channel blockade, including antiarrhythmic agents, tricyclic antidepressants, opiate-like analgesics, and cocaine, are linked with an increased susceptibility to cardiac arrhythmias and sudden death. Computer simulations ... Full text Link to item Cite

Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments.

Journal article Circulation · September 1991 Featured Publication BACKGROUND: The use of flecainide and encainide was terminated in the Cardiac Arrhythmia Suppression Trial because of an excess of sudden cardiac deaths in the active treatment group. Such events might arise from reentrant rhythms initiated by premature st ... Full text Link to item Cite

Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias.

Journal article Circulation · December 1990 Featured Publication Although work on class III antiarrhythmics remains at an early stage, these agents still appear to possess greater efficacy and less proarrhythmia than conventional class I agents in those experimental arrhythmia models considered to be most representative ... Full text Cite

Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking.

Journal article Circ Res · September 1989 Featured Publication Lidocaine block of the cardiac sodium channel is believed to be primarily a function of channel state. For subthreshold potentials, block is limited to the inactivated state, whereas above threshold, block results from the combination of open- and inactiva ... Full text Link to item Cite

Characterizing activity-dependent processes with a piecewise exponential model.

Journal article Biometrics · June 1988 Featured Publication The response of some biological processes is dependent on the frequency of stimulation. With first-order processes, the response is driven exponentially to an equilibrium determined by the value of the driving function. When the stimulus or driving functio ... Full text Cite

Phasic ion channel blockade. A kinetic model and parameter estimation procedure.

Journal article Mol Pharmacol · October 1985 Featured Publication For excitable membranes, use and frequency dependence represent a progressive incorporation of drug into gated ion channels with repetitive stimulation. In contrast to receptors where access to ligand is continuous in time, we define guarded receptors, suc ... Link to item Cite

Unitary sodium channels in isolated cardiac myocytes of rabbit.

Journal article Circ Res · December 1983 Featured Publication Transmembrane ionic movements are thought to occur through special membrane areas or channels. Until recently, it has not been possible to study the properties of individual ionic channels, directly. We have used the extracellular patch clamp technique to ... Full text Link to item Cite

A new information system for medical practice.

Journal article Archives of internal medicine · August 1975 Featured Publication A data bank containing our clinical experience with more than 3,000 patients with suspected and documented ischemic heart disease is being used to expand our ability to care for patients. This report describes how the experience is documented, stored, and ... Full text Cite

The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.

Journal article The Journal of clinical investigation · October 1973 Featured Publication THE CONCEPT OF AN ABNORMALITY OF GLUTAMINE METABOLISM IN PRIMARY GOUT WAS FIRST PROPOSED ON THE BASIS OF ISOTOPE DATA: when [(15)N]glycine was administered to gouty subjects, there was disproportionately great enrichment of N-(3 + 9) of uric acid, which de ... Full text Cite

Current density and electrically induced ventricular fibrillation.

Journal article Medical instrumentation · March 1973 Featured Publication Cite

Computer computations of cardiac output using the gamma function.

Journal article Journal of applied physiology · February 1970 Featured Publication Full text Cite

Analysis of categorical data by linear models.

Journal article Biometrics · September 1969 Featured Publication Full text Cite

Pressure-flow studies in man. An evaluation of the duration of the phases of systole.

Journal article The Journal of clinical investigation · May 1969 Featured Publication This study was designed to assess the independent effects of stroke volume and heart rate on the phases of systole and other selected hemodynamic parameters. By means of the pressure gradient technique instantaneous blood pressure and flow were recorded in ... Full text Cite