James B. Duke Professor Emeritus of Medicine
We are interested in anything which pertains to the biological production of O2- and the consequences thereto. In Escherichia coli, increased O2- elicits a group of coordinately regulated enzymes, called the soxRS regulon. We have identified several members of this regulon and explained thier contribution to the net defense. Having previously shown that E. coli contains one constitutive and one inducible superoxide dismutase we have now identified a third, which is periplasmic. We are exploring the properties of Mn(III) porhins, that mimic the activity of SOD. We are of the opinion that such compounds may make useful pharmaceuticals.
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