Mariano Agustin Garcia-Blanco
Adjunct Professor in the Molecular Genetics and Microbiology
Human and viral genes are complex genetic units of information that are tightly regulated. The laboratory studies three aspects of this regulation: the interface between synthesis of mammalian messenger RNAs and the processing events required to mature these transcripts, the alternative processing of these messenger RNAs to produce multiple proteins from one gene, and the regulation of gene expression in human pathogenic flaviviruses.
In the great majority of human transcripts coding information is found in short exons that are identified and ligated together in the process known as pre-messenger RNA splicing. The complex nature of genes provides for versatility of expression because one gene can encode for many proteins by altering the selection of exons to be included in the messenger. This process is known as alternative splicing and it is the major engine of proteome diversity in humans. Alternative splicing is tightly regulated in normal development and is deregulated in disease. The evolution of alternative splicing probably accounts for the possibility to maintain a limited number of genes while increasing tissue diversity.
The importance of connections between RNA processing and synthesis (transcription) has recently come to light. The molecular nature of these connections remains unresolved. The laboratory investigates these connections, physical and functional, between RNA polymerase II transcript elongation and alternative splicing. This work is focused on a protein found to be a repressor of HIV-1 transcription elongation, CA150. CA150 appears to physically and functionally link the elongating RNAP II complex with the splicing machinery.
My laboratory also studies the regulation of processing of messenger RNAs focusing on the alternative splicing of the fibroblast growth factor receptor-2 (FGFR2) transcripts. FGFR2 transcripts are alternatively spliced to yield regulated expression of two receptors with dramatically different ligand specificity. Not only is this process critical for normal development of many epithelial tissues, but also during progression of prostate tumors the alternative splicing of FGFR2 is abnormal. We have characterized the cis-elements responsible for regulation of alternative splicing in FGFR2 and some of the trans-acting factors that control this process. In the last two years we have identified two critical trans-acting factors, the exon repressor PTB and the activator FXH. We have also developed novel reporters that will assay the alternative splicing of FGFR2 in tissues and tumors in living cells and animals. Finally we are also investigating the networks that globally determine alternative splicing of large classes of gene products. We are doing this with a combination of depletion by RNA interference and complementation together with en masse analysis using microarrays.
Finally the laboratory has recently begun a study of the RNA-protein interactions that dictate gene expression in two families of pathogenic flaviviruses, yellow fever virus (YFV) and dengue viruses (DV). These agents are major health risks in the tropics and represent an emerging danger to the US population. This threat was announced by the West Nile virus epidemic, caused by a highly related flavivirus. Little is known about the molecular biology of YFV and DV, and my laboratory is applying tools and methods we have developed to study human gene expression to shed light into critical functions of these important pathogens.
In the great majority of human transcripts coding information is found in short exons that are identified and ligated together in the process known as pre-messenger RNA splicing. The complex nature of genes provides for versatility of expression because one gene can encode for many proteins by altering the selection of exons to be included in the messenger. This process is known as alternative splicing and it is the major engine of proteome diversity in humans. Alternative splicing is tightly regulated in normal development and is deregulated in disease. The evolution of alternative splicing probably accounts for the possibility to maintain a limited number of genes while increasing tissue diversity.
The importance of connections between RNA processing and synthesis (transcription) has recently come to light. The molecular nature of these connections remains unresolved. The laboratory investigates these connections, physical and functional, between RNA polymerase II transcript elongation and alternative splicing. This work is focused on a protein found to be a repressor of HIV-1 transcription elongation, CA150. CA150 appears to physically and functionally link the elongating RNAP II complex with the splicing machinery.
My laboratory also studies the regulation of processing of messenger RNAs focusing on the alternative splicing of the fibroblast growth factor receptor-2 (FGFR2) transcripts. FGFR2 transcripts are alternatively spliced to yield regulated expression of two receptors with dramatically different ligand specificity. Not only is this process critical for normal development of many epithelial tissues, but also during progression of prostate tumors the alternative splicing of FGFR2 is abnormal. We have characterized the cis-elements responsible for regulation of alternative splicing in FGFR2 and some of the trans-acting factors that control this process. In the last two years we have identified two critical trans-acting factors, the exon repressor PTB and the activator FXH. We have also developed novel reporters that will assay the alternative splicing of FGFR2 in tissues and tumors in living cells and animals. Finally we are also investigating the networks that globally determine alternative splicing of large classes of gene products. We are doing this with a combination of depletion by RNA interference and complementation together with en masse analysis using microarrays.
Finally the laboratory has recently begun a study of the RNA-protein interactions that dictate gene expression in two families of pathogenic flaviviruses, yellow fever virus (YFV) and dengue viruses (DV). These agents are major health risks in the tropics and represent an emerging danger to the US population. This threat was announced by the West Nile virus epidemic, caused by a highly related flavivirus. Little is known about the molecular biology of YFV and DV, and my laboratory is applying tools and methods we have developed to study human gene expression to shed light into critical functions of these important pathogens.
Current Appointments & Affiliations
- Adjunct Professor in the Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014
- Director, Center for RNA Biology, Molecular Genetics and Microbiology, Basic Science Departments 2002
Contact Information
- 268 CARL, Bx 3054, Durham, NC 27710
- 108 Basic Science Building Utm, 301 University Boulevard, Galveston, TX 77555-0645
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garci001@mc.duke.edu
(919) 613-8636
- Background
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Education, Training, & Certifications
- Ph.D., Yale University 1988
- M.D., Yale University 1984
- B.A., Harvard University 1977
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Duke Appointment History
- Adjunct Professor in the Department of Medicine, Medicine, Cardiology, Medicine 2014 - 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1990 - 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013 - 2015
- Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2014
- Professor of Medicine, Medicine, Cardiology, Medicine 2002 - 2014
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2002
- Associate Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1999 - 2002
- Professor of Genetics, School of Medicine, Duke University 2002
- Associate Professor of Genetics, School of Medicine, Duke University 1999 - 2001
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1997 - 1999
- Assistant Research Professor of Medicine, Medicine, Clinical Science Departments 1994 - 1999
- Assistant Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1994 - 1998
- Associate Professor in Molecular Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1996 - 1997
- Assistant Professor of Molecular Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1990 - 1996
- Recognition
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In the News
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MAR 23, 2017 Duke Health News -
JUL 16, 2014 Singapore Today
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Awards & Honors
- Research
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Selected Grants
- HIF-1 driven therapeutic resistance mechanisms in chest wall recurrences of inflammatory breast cancer (IBC) awarded by Inflammatory Breast Cancer Research Foundation 2013 - 2016
- Discovery and development of broad spectrum anti-flaviviral drugs awarded by National Institutes of Health 2010 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- The prevalence and importance of epithelial plasticity in metastatic prostate cancer awarded by Department of Defense 2013 - 2015
- Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chain awarded by National Institutes of Health 2009 - 2015
- Regulation of IL7R splicing by DDX39B and its role in Multiple Sclerosis awarded by National Institutes of Health 2014 - 2015
- Targeting dengue in the mosquito with small molecules awarded by Johns Hopkins University - School of Public Health 2012 - 2015
- The role of host RNA-binding proteins in regulating dengue virus replication awarded by National Institutes of Health 2014 - 2015
- Alternative splicing and epithelial-mesenchymal plasticity in prostate tumors awarded by National Institutes of Health 2008 - 2014
- Truncated GLI1 In Glioblastoma awarded by National Institutes of Health 2014
- Host-pathogen interactions in hepatitis C virus replication awarded by National Institutes of Health 2009 - 2014
- Regulation of tumorigenesis by alternative pre-mRNA splicing awarded by National Institutes of Health 2012 - 2013
- Structural, Biochemical and Functional Studies of RNAPII CTD Interacting Proteins awarded by National Institutes of Health 2008 - 2012
- IsoCyte Laser Scanning Plate Cytometer for High-throughput, High-content Assays awarded by National Institutes of Health 2011 - 2012
- Regulation of alternative splicing by microenvironment signaling awarded by National Institutes of Health 2009 - 2011
- Function of nucleic acid binding DENV host factors awarded by University of North Carolina - Chapel Hill 2009 - 2011
- Elucidation of the Mechanisms of CD8+ T Cell Noncytolytic Antiviral Response awarded by National Institutes of Health 2009 - 2010
- Regulation of Alternative Splicing of FGFR2 pre-mRNA awarded by National Institutes of Health 2001 - 2010
- RNA-Protein Interactions in Flavivirus Infection awarded by National Institutes of Health 2007 - 2009
- Connections between mRNA elongation and splicing awarded by National Institutes of Health 2004 - 2009
- Integrated instrument systems for maintenance and delivery of RNAi libraries awarded by National Institutes of Health 2008 - 2009
- Cis and Trans-acting Factors in HCV Gene Expression awarded by National Institutes of Health 2005 - 2008
- Duke PREP: Minority Recruitment into Biomedical Sciences awarded by National Institutes of Health 2003 - 2008
- Imaging Alternative Splicing During Tumor Progression awarded by National Institutes of Health 2002 - 2007
- Role of PhosphoCTD in Spliceosome Assembly awarded by National Science Foundation 2001 - 2004
- Molecular Imaging Center Planning Grant awarded by National Institutes of Health 2000 - 2004
- RNAP II CTD's Role in RNA Transcription and Processing awarded by National Institutes of Health 2002 - 2004
- Cellular Coactivators of the HIV 1 Promoter awarded by National Institutes of Health 1997 - 2004
- Role Of Cellular Coactivators Of The Hiv-1 Promoter awarded by National Institutes of Health 1997 - 1999
- Biochemical Analysis Of Pre-Mrna Splicing awarded by National Institutes of Health 1997 - 1999
- A Biochemical Analysis Of Pre-Mrna Splicing awarded by National Institutes of Health 1994 - 1998
- Microscopic Imaging Laboratory awarded by National Science Foundation 1996 - 1997
- Acquisition Of Phosphorimager awarded by National Science Foundation 1995 - 1997
- Transcriptional Regulation Of Hiv Gene Expression awarded by National Institutes of Health 1995 - 1996
- Transcriptional Regualtion Of Hiv Gene Expression awarded by National Institutes of Health 1992 - 1996
- Regulation Of Pre-Mrna Splicing By Pptb awarded by National Institutes of Health 1991 - 1993
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Schott, Geraldine, Gaddiel Galarza-Muñoz, Noe Trevino, Xiaoting Chen, Matthew Weirauch, Simon G. Gregory, Shelton S. Bradrick, and Mariano A. Garcia-Blanco. “U2AF2 binds IL7R exon 6 ectopically and represses its inclusion.” Rna, February 10, 2021. https://doi.org/10.1261/rna.078279.120.Full Text Link to Item
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Schott, Geraldine, and Mariano A. Garcia-Blanco. “MHC Class III RNA Binding Proteins and Immunity.” Rna Biol, December 20, 2020, 1–7. https://doi.org/10.1080/15476286.2020.1860388.Full Text Link to Item
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Garcia-Blanco, Mariano A. “To Splice or Not to Splice, That Is the Treatment.” Cell Chem Biol 27, no. 12 (December 17, 2020): 1453–55. https://doi.org/10.1016/j.chembiol.2020.12.002.Full Text Link to Item
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Prasanth, K Reddisiva, Minato Hirano, W Samuel Fagg, Eileen T. McAnarney, Chao Shan, Xuping Xie, Adam Hage, et al. “Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses.” Antiviral Res 182 (October 2020): 104874. https://doi.org/10.1016/j.antiviral.2020.104874.Full Text Link to Item
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Campos, Rafael K., HR Sagara Wijeratne, Premal Shah, Mariano A. Garcia-Blanco, and Shelton S. Bradrick. “Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins.” Nucleic Acids Res 48, no. 17 (September 25, 2020): 9872–85. https://doi.org/10.1093/nar/gkaa717.Full Text Link to Item
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Muruato, Antonio E., Camila R. Fontes-Garfias, Ping Ren, Mariano A. Garcia-Blanco, Vineet D. Menachery, Xuping Xie, and Pei-Yong Shi. “A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation.” Nat Commun 11, no. 1 (August 13, 2020): 4059. https://doi.org/10.1038/s41467-020-17892-0.Full Text Link to Item
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Kabir, Md Alamgir, Ruben Soto-Acosta, Sandhya Sharma, Shelton S. Bradrick, Mariano A. Garcia-Blanco, Massimo Caputi, and Waseem Asghar. “An antibody panel for highly specific detection and differentiation of Zika virus.” Sci Rep 10, no. 1 (July 17, 2020): 11906. https://doi.org/10.1038/s41598-020-68635-6.Full Text Link to Item
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Kanodia, Pulkit, K Reddisiva Prasanth, Vicky C. Roa-Linares, Shelton S. Bradrick, Mariano A. Garcia-Blanco, and W Allen Miller. “A rapid and simple quantitative method for specific detection of smaller coterminal RNA by PCR (DeSCo-PCR): application to the detection of viral subgenomic RNAs.” Rna 26, no. 7 (July 2020): 888–901. https://doi.org/10.1261/rna.074963.120.Full Text Link to Item
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Kim, Byungil, Sarah Arcos, Katherine Rothamel, Jeffrey Jian, Kristie L. Rose, W Hayes McDonald, Yuqi Bian, et al. “Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.” Mol Cell 78, no. 4 (May 21, 2020): 624-640.e7. https://doi.org/10.1016/j.molcel.2020.04.013.Full Text Link to Item
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Liao, Kuo-Chieh, Vanessa Chuo, W Samuel Fagg, Shelton S. Bradrick, Julien Pompon, and Mariano A. Garcia-Blanco. “The RNA binding protein Quaking represses host interferon response by downregulating MAVS.” Rna Biol 17, no. 3 (March 2020): 366–80. https://doi.org/10.1080/15476286.2019.1703069.Full Text Link to Item
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Barrows, Nicholas J., Yesseinia Anglero-Rodriguez, Byungil Kim, Sharon F. Jamison, Caroline Le Sommer, Charles E. McGee, James L. Pearson, et al. “Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis.” Sci Rep 9, no. 1 (July 4, 2019): 9711. https://doi.org/10.1038/s41598-019-45910-9.Full Text Link to Item
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Anderson, Danielle E., Kristin Pfeffermann, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L. Corcoran, et al. “Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.” Mbio 10, no. 3 (May 14, 2019). https://doi.org/10.1128/mBio.00826-19.Full Text Link to Item
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Soto-Acosta, Ruben, Xuping Xie, Chao Shan, Coleman K. Baker, Pei-Yong Shi, Shannan L. Rossi, Mariano A. Garcia-Blanco, and Shelton Bradrick. “Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA.” Elife 7 (December 4, 2018). https://doi.org/10.7554/eLife.39023.Full Text Link to Item
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Fang, Jingru, Colette Pietzsch, Palaniappan Ramanathan, Rodrigo I. Santos, Philipp A. Ilinykh, Mariano A. Garcia-Blanco, Alexander Bukreyev, and Shelton S. Bradrick. “Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis.” Mbio 9, no. 5 (October 9, 2018). https://doi.org/10.1128/mBio.01771-18.Full Text Link to Item
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Liao, Kuo-Chieh, Vanessa Chuo, Wy Ching Ng, Suat Peng Neo, Julien Pompon, Jayantha Gunaratne, Eng Eong Ooi, and Mariano A. Garcia-Blanco. “Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.” Rna 24, no. 6 (June 2018): 803–14. https://doi.org/10.1261/rna.064006.117.Full Text Link to Item
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Barrows, Nicholas J., Rafael K. Campos, Kuo-Chieh Liao, K Reddisiva Prasanth, Ruben Soto-Acosta, Shih-Chia Yeh, Geraldine Schott-Lerner, et al. “Biochemistry and Molecular Biology of Flaviviruses.” Chem Rev 118, no. 8 (April 25, 2018): 4448–82. https://doi.org/10.1021/acs.chemrev.7b00719.Full Text Link to Item
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Reid, David W., Rafael K. Campos, Jessica R. Child, Tianli Zheng, Kitti Wing Ki Chan, Shelton S. Bradrick, Subhash G. Vasudevan, Mariano A. Garcia-Blanco, and Christopher V. Nicchitta. “Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis.” J Virol 92, no. 7 (April 1, 2018). https://doi.org/10.1128/JVI.01766-17.Full Text Open Access Copy Link to Item
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Bidet, Katell, and Mariano A. Garcia-Blanco. “Flaviviral RNA Structures and Their Role in Replication and Immunity.” Adv Exp Med Biol 1062 (2018): 45–62. https://doi.org/10.1007/978-981-10-8727-1_4.Full Text Link to Item
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Campos, Rafael K., Mariano A. Garcia-Blanco, and Shelton S. Bradrick. “Roles of Pro-viral Host Factors in Mosquito-Borne Flavivirus Infections.” Curr Top Microbiol Immunol 419 (2018): 43–67. https://doi.org/10.1007/82_2017_26.Full Text Link to Item
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Wang, Bi-Dar, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, et al. “Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.” Nat Commun 8 (September 27, 2017): 16161. https://doi.org/10.1038/ncomms16161.Full Text Link to Item
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Guo, Fangjian, Alexander R. Norton, Erika L. Fuchs, Jacqueline M. Hirth, Mariano A. Garcia-Blanco, and Abbey B. Berenson. “Provider-patient communication about Zika during prenatal visits.” Prev Med Rep 7 (September 2017): 26–29. https://doi.org/10.1016/j.pmedr.2017.05.003.Full Text Link to Item
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Pasman, Zvi, and Mariano A. Garcia-Blanco. “Early history of circular RNAs, children of splicing.” Rna Biol 14, no. 8 (August 3, 2017): 975–77. https://doi.org/10.1080/15476286.2016.1227903.Full Text Link to Item
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Aliota, Matthew T., Leda Bassit, Shelton S. Bradrick, Bryan Cox, Mariano A. Garcia-Blanco, Christina Gavegnano, Thomas C. Friedrich, et al. “Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network.” Antiviral Res 144 (August 2017): 223–46. https://doi.org/10.1016/j.antiviral.2017.06.001.Full Text Link to Item
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Pompon, Julien, Menchie Manuel, Geok Kee Ng, Benjamin Wong, Chao Shan, Gayathri Manokaran, Ruben Soto-Acosta, et al. “Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission.” Plos Pathog 13, no. 7 (July 2017): e1006535. https://doi.org/10.1371/journal.ppat.1006535.Full Text Link to Item
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Wang, Bi-Dar, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, et al. “Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.” Nat Commun 8 (June 30, 2017): 15921. https://doi.org/10.1038/ncomms15921.Full Text Link to Item
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Ng, Wy Ching, Ruben Soto-Acosta, Shelton S. Bradrick, Mariano A. Garcia-Blanco, and Eng Eong Ooi. “The 5' and 3' Untranslated Regions of the Flaviviral Genome.” Viruses 9, no. 6 (June 6, 2017). https://doi.org/10.3390/v9060137.Full Text Link to Item
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Galarza-Muñoz, Gaddiel, Farren B. S. Briggs, Irina Evsyukova, Geraldine Schott-Lerner, Edward M. Kennedy, Tinashe Nyanhete, Liuyang Wang, et al. “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.” Cell 169, no. 1 (March 23, 2017): 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007.Full Text Link to Item
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Campos, Rafael K., Benjamin Wong, Xuping Xie, Yi-Fan Lu, Pei-Yong Shi, Julien Pompon, Mariano A. Garcia-Blanco, and Shelton S. Bradrick. “RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation.” J Virol 91, no. 4 (February 15, 2017). https://doi.org/10.1128/JVI.01706-16.Full Text Link to Item
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Gokhale, Nandan S., Alexa B. R. McIntyre, Michael J. McFadden, Allison E. Roder, Edward M. Kennedy, Jorge A. Gandara, Sharon E. Hopcraft, et al. “N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.” Cell Host Microbe 20, no. 5 (November 9, 2016): 654–65. https://doi.org/10.1016/j.chom.2016.09.015.Full Text Link to Item
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Garcia-Blanco, Mariano A., Subhash G. Vasudevan, Shelton S. Bradrick, and Christopher Nicchitta. “Flavivirus RNA transactions from viral entry to genome replication.” Antiviral Res 134 (October 2016): 244–49. https://doi.org/10.1016/j.antiviral.2016.09.010.Full Text Link to Item
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Somarelli, Jason A., Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, Alexander J. Hish, Shivee Gilja, et al. “Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.” Mol Cell Biol 36, no. 19 (October 1, 2016): 2503–13. https://doi.org/10.1128/MCB.00373-16.Full Text Open Access Copy Link to Item
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Ward, Alex Michael, Meredith E. K. Calvert, Leah R. Read, Seokyoung Kang, Brandt E. Levitt, George Dimopoulos, Shelton S. Bradrick, Jayantha Gunaratne, and Mariano A. Garcia-Blanco. “The Golgi associated ERI3 is a Flavivirus host factor.” Sci Rep 6 (September 29, 2016): 34379. https://doi.org/10.1038/srep34379.Full Text Link to Item
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Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.Full Text Open Access Copy Link to Item
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Barrows, Nicholas J., Rafael K. Campos, Steven T. Powell, K Reddisiva Prasanth, Geraldine Schott-Lerner, Ruben Soto-Acosta, Gaddiel Galarza-Muñoz, et al. “A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection.” Cell Host Microbe 20, no. 2 (August 10, 2016): 259–70. https://doi.org/10.1016/j.chom.2016.07.004.Full Text Link to Item
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Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.Full Text Open Access Copy Link to Item
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Weaver, Scott C., Federico Costa, Mariano A. Garcia-Blanco, Albert I. Ko, Guilherme S. Ribeiro, George Saade, Pei-Yong Shi, and Nikos Vasilakis. “Zika virus: History, emergence, biology, and prospects for control.” Antiviral Res 130 (June 2016): 69–80. https://doi.org/10.1016/j.antiviral.2016.03.010.Full Text Link to Item
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Zhang, Tian, Rengasamy Boominathan, Brad Foulk, Chandra Rao, Gabor Kemeny, John H. Strickler, James L. Abbruzzese, et al. “Development of a Novel c-MET-Based CTC Detection Platform.” Mol Cancer Res 14, no. 6 (June 2016): 539–47. https://doi.org/10.1158/1541-7786.MCR-16-0011.Full Text Open Access Copy Link to Item
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Shan, Chao, Xuping Xie, Alan D. T. Barrett, Mariano A. Garcia-Blanco, Robert B. Tesh, Pedro Fernando da Costa Vasconcelos, Nikos Vasilakis, Scott C. Weaver, and Pei-Yong Shi. “Zika Virus: Diagnosis, Therapeutics, and Vaccine.” Acs Infect Dis 2, no. 3 (March 11, 2016): 170–72. https://doi.org/10.1021/acsinfecdis.6b00030.Full Text Link to Item
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Phillips, Stacia L., Erik J. Soderblom, Shelton S. Bradrick, and Mariano A. Garcia-Blanco. “Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication.” Mbio 7, no. 1 (January 5, 2016): e01865–e01815. https://doi.org/10.1128/mBio.01865-15.Full Text Link to Item
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Bradrick, Shelton S., and Mariano A. Garcia-Blanco. “RNA-based methods in virology.” Methods 91 (December 2015): 1–2. https://doi.org/10.1016/j.ymeth.2015.11.014.Full Text Link to Item
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Phillips, Stacia L., Mariano A. Garcia-Blanco, and Shelton S. Bradrick. “Antisense-mediated affinity purification of dengue virus ribonucleoprotein complexes from infected cells.” Methods 91 (December 2015): 13–19. https://doi.org/10.1016/j.ymeth.2015.08.008.Full Text Link to Item
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Manokaran, Gayathri, Esteban Finol, Chunling Wang, Jayantha Gunaratne, Justin Bahl, Eugenia Z. Ong, Hwee Cheng Tan, et al. “Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.” Science 350, no. 6257 (October 9, 2015): 217–21. https://doi.org/10.1126/science.aab3369.Full Text Link to Item
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Somarelli, Jason A., Mary-Keara Boss, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Carcinosarcomas: tumors in transition?” Histol Histopathol 30, no. 6 (June 2015): 673–87. https://doi.org/10.14670/HH-30.673.Full Text Link to Item
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Garcia-Blanco, Mariano A. “Know thyself.” Rna 21, no. 4 (April 2015): 525–26. https://doi.org/10.1261/rna.050138.115.Full Text Link to Item
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Pompon, Julien, and Mariano A. Garcia-Blanco. “RNA: jack of all trades and master of all.” Cell 160, no. 4 (February 12, 2015): 579–80. https://doi.org/10.1016/j.cell.2015.01.047.Full Text Link to Item
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Li, Jing, Simon G. Gregory, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “Using circulating tumor cells to inform on prostate cancer biology and clinical utility.” Crit Rev Clin Lab Sci 52, no. 4 (2015): 191–210. https://doi.org/10.3109/10408363.2015.1023430.Full Text Link to Item
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Schaeffer, Daneen, Jason A. Somarelli, Gabi Hanna, Gregory M. Palmer, and Mariano A. Garcia-Blanco. “Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.” Mol Cell Biol 34, no. 18 (September 15, 2014): 3486–99. https://doi.org/10.1128/MCB.00694-14.Full Text Link to Item
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Bidet, Katell, and Mariano A. Garcia-Blanco. “Flaviviral RNAs: weapons and targets in the war between virus and host.” The Biochemical Journal 462, no. 2 (September 2014): 215–30. https://doi.org/10.1042/bj20140456.Full Text
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Bitting, Rhonda L., Daneen Schaeffer, Jason A. Somarelli, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “The role of epithelial plasticity in prostate cancer dissemination and treatment resistance.” Cancer Metastasis Rev 33, no. 2–3 (September 2014): 441–68. https://doi.org/10.1007/s10555-013-9483-z.Full Text Link to Item
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Ware, Kathryn E., Mariano A. Garcia-Blanco, Andrew J. Armstrong, and Scott M. Dehm. “Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer.” Endocr Relat Cancer 21, no. 4 (August 2014): T87–103. https://doi.org/10.1530/ERC-13-0470.Full Text Link to Item
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Bidet, Katell, Dhivya Dadlani, and Mariano A. Garcia-Blanco. “G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.” Plos Pathog 10, no. 7 (July 2014): e1004242. https://doi.org/10.1371/journal.ppat.1004242.Full Text Link to Item
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Bogerd, Hal P., Rebecca L. Skalsky, Edward M. Kennedy, Yuki Furuse, Adam W. Whisnant, Omar Flores, Kimberly L. W. Schultz, et al. “Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.” J Virol 88, no. 14 (July 2014): 8065–76. https://doi.org/10.1128/JVI.00985-14.Full Text Link to Item
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Skalsky, Rebecca L., Ken E. Olson, Carol D. Blair, Mariano A. Garcia-Blanco, and Bryan R. Cullen. “A "microRNA-like" small RNA expressed by Dengue virus?” Proc Natl Acad Sci U S A 111, no. 23 (June 10, 2014): E2359. https://doi.org/10.1073/pnas.1406854111.Full Text Link to Item
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Krishnan, Manoj N., and Mariano A. Garcia-Blanco. “Targeting host factors to treat West Nile and dengue viral infections.” Viruses 6, no. 2 (February 10, 2014): 683–708. https://doi.org/10.3390/v6020683.Full Text Link to Item
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Barrows, Nicholas J., Sharon F. Jamison, Shelton S. Bradrick, Caroline Le Sommer, So Young Kim, James Pearson, and Mariano A. Garcia-Blanco. “Functional genomics approach for the identification of human host factors supporting dengue viral propagation.” Methods Mol Biol 1138 (2014): 285–99. https://doi.org/10.1007/978-1-4939-0348-1_18.Full Text Link to Item
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Ward, Alex M., J. Gunaratne, and Mariano A. Garcia-Blanco. “Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry.” Methods Mol Biol 1138 (2014): 253–70. https://doi.org/10.1007/978-1-4939-0348-1_16.Full Text Link to Item
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Bitting, Rhonda L., Rengasamy Boominathan, Chandra Rao, Gabor Kemeny, Brad Foulk, Mariano A. Garcia-Blanco, Mark Connelly, and Andrew J. Armstrong. “Development of a method to isolate circulating tumor cells using mesenchymal-based capture.” Methods 64, no. 2 (December 1, 2013): 129–36. https://doi.org/10.1016/j.ymeth.2013.06.034.Full Text Link to Item
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Homa, Nicholas J., Raul Salinas, Eleonora Forte, Timothy J. Robinson, Mariano A. Garcia-Blanco, and Micah A. Luftig. “Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.” Journal of Virology 87, no. 22 (November 2013): 12291–301. https://doi.org/10.1128/jvi.02464-13.Full Text
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Coiras, Mayte, Marta Montes, Immaculada Montanuy, María Rosa López-Huertas, Elena Mateos, Caroline Le Sommer, Mariano A. Garcia-Blanco, Cristina Hernández-Munain, José Alcamí, and Carlos Suñé. “Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication.” Retrovirology 10 (October 28, 2013): 124. https://doi.org/10.1186/1742-4690-10-124.Full Text Link to Item
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Evsyukova, Irina, Shelton S. Bradrick, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.” Rna (New York, N.Y.) 19, no. 1 (January 2013): 103–15. https://doi.org/10.1261/rna.035410.112.Full Text
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Somarelli, Jason A., Daneen Schaeffer, Reggie Bosma, Vivian I. Bonano, Jang Wook Sohn, Gabor Kemeny, Abhinav Ettyreddy, and Mariano A. Garcia-Blanco. “Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.” Rna (New York, N.Y.) 19, no. 1 (January 2013): 116–27. https://doi.org/10.1261/rna.035097.112.Full Text
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Robinson, Timothy J., Eleonora Forte, Raul E. Salinas, Shaan Puri, Matthew Marengo, Mariano A. Garcia-Blanco, and Micah A. Luftig. “SplicerEX: a tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data.” Rna (New York, N.Y.) 18, no. 8 (August 2012): 1435–45. https://doi.org/10.1261/rna.033621.112.Full Text
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Le Sommer, Caroline, Nicholas J. Barrows, Shelton S. Bradrick, James L. Pearson, and Mariano A. Garcia-Blanco. “G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication.” Plos Negl Trop Dis 6, no. 9 (2012): e1820. https://doi.org/10.1371/journal.pntd.0001820.Full Text Link to Item
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Zhang, X., P. J. Nicholls, G. Laje, T. D. Sotnikova, R. R. Gainetdinov, P. R. Albert, G. Rajkowska, et al. “A functional alternative splicing mutation in human tryptophan hydroxylase-2.” Mol Psychiatry 16, no. 12 (December 2011): 1169–76. https://doi.org/10.1038/mp.2010.99.Full Text Link to Item
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Ward, Alex Michael, Katell Bidet, Ang Yinglin, Siok Ghee Ler, Kelly Hogue, Walter Blackstock, Jayantha Gunaratne, and Mariano A. Garcia-Blanco. “Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures.” Rna Biol 8, no. 6 (November 2011): 1173–86. https://doi.org/10.4161/rna.8.6.17836.Full Text Link to Item
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Armstrong, Andrew J., Matthew S. Marengo, Sebastian Oltean, Gabor Kemeny, Rhonda L. Bitting, James D. Turnbull, Christina I. Herold, Paul K. Marcom, Daniel J. George, and Mariano A. Garcia-Blanco. “Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers.” Mol Cancer Res 9, no. 8 (August 2011): 997–1007. https://doi.org/10.1158/1541-7786.MCR-10-0490.Full Text Link to Item
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Miller, Heather B., Timothy J. Robinson, Raluca Gordân, Alexander J. Hartemink, and Mariano A. Garcia-Blanco. “Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing.” Rna (New York, N.Y.) 17, no. 4 (April 2011): 665–74. https://doi.org/10.1261/rna.2462011.Full Text
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Armstrong, Andrew J., Stephen J. Freedland, and Mariano Garcia-Blanco. “Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy.” Asian Journal of Andrology 13, no. 2 (March 2011): 179–80. https://doi.org/10.1038/aja.2010.169.Full Text
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Anwar, Azlinda, Takamitsu Hosoya, Kok Mun Leong, Hiroshi Onogi, Yukiko Okuno, Toshiyuki Hiramatsu, Hiroko Koyama, Masaaki Suzuki, Masatoshi Hagiwara, and Mariano A. Garcia-Blanco. “The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly.” Plos One 6, no. 8 (2011): e23246. https://doi.org/10.1371/journal.pone.0023246.Full Text Link to Item
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Ward, A. M., K. Bidet, A. Yinglin, S. G. Ler, K. Hogue, W. Blackstock, J. Gunaratne, and M. A. Garcia-Blanco. “Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures.” Rna Biology 8, no. 6 (January 1, 2011). https://doi.org/10.4161/rna.8.6.Full Text
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Barrows, Nicholas J., Caroline Le Sommer, Mariano A. Garcia-Blanco, and James L. Pearson. “Factors affecting reproducibility between genome-scale siRNA-based screens.” J Biomol Screen 15, no. 7 (August 2010): 735–47. https://doi.org/10.1177/1087057110374994.Full Text Link to Item
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Evsyukova, Irina, Jason A. Somarelli, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Alternative splicing in multiple sclerosis and other autoimmune diseases.” Rna Biol 7, no. 4 (July 2010): 462–73. https://doi.org/10.4161/rna.7.4.12301.Full Text Open Access Copy Link to Item
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Robinson, Timothy J., Michaela A. Dinan, Mark Dewhirst, Mariano A. Garcia-Blanco, and James L. Pearson. “SplicerAV: a tool for mining microarray expression data for changes in RNA processing.” Bmc Bioinformatics 11 (February 25, 2010): 108. https://doi.org/10.1186/1471-2105-11-108.Full Text Open Access Copy Link to Item
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García-Blanco, M. A. “Editorial: Biotechnology and Puerto Rico: Promises that must be kept.” Puerto Rico Health Sciences Journal 28, no. 3 (October 26, 2009): 217–18.
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Rodriguez-Martin, Teresa, Karen Anthony, Mariano A. Garcia-Blanco, S Gary Mansfield, Brian H. Anderton, and Jean-Marc Gallo. “Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing.” Hum Mol Genet 18, no. 17 (September 1, 2009): 3266–73. https://doi.org/10.1093/hmg/ddp264.Full Text Link to Item
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Anwar, Azlinda, K. M. Leong, Mary L. Ng, Justin J. H. Chu, and Mariano A. Garcia-Blanco. “The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery.” J Biol Chem 284, no. 25 (June 19, 2009): 17021–29. https://doi.org/10.1074/jbc.M109.006239.Full Text Link to Item
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Yeowell, Heather N., Linda C. Walker, David M. Mauger, Puneet Seth, and Mariano A. Garcia-Blanco. “TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.” J Invest Dermatol 129, no. 6 (June 2009): 1402–11. https://doi.org/10.1038/jid.2008.386.Full Text Link to Item
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Miller, Heather B., Kevin O. Saunders, Georgia D. Tomaras, and Mariano A. Garcia-Blanco. “Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs.” Plos One 4, no. 5 (May 27, 2009): e5710. https://doi.org/10.1371/journal.pone.0005710.Full Text Link to Item
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Marengo, Matthew S., and Mariano A. Garcia-Blanco. “Shedding UV light on alternative splicing.” Cell 137, no. 4 (May 15, 2009): 600–602. https://doi.org/10.1016/j.cell.2009.04.054.Full Text Link to Item
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Sessions, October M., Nicholas J. Barrows, Jayme A. Souza-Neto, Timothy J. Robinson, Christine L. Hershey, Mary A. Rodgers, Jose L. Ramirez, et al. “Discovery of insect and human dengue virus host factors.” Nature 458, no. 7241 (April 23, 2009): 1047–50. https://doi.org/10.1038/nature07967.Full Text Link to Item
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Natalizio, Barbara J., Nicole D. Robson-Dixon, and Mariano A. Garcia-Blanco. “The Carboxyl-terminal Domain of RNA Polymerase II Is Not Sufficient to Enhance the Efficiency of Pre-mRNA Capping or Splicing in the Context of a Different Polymerase.” J Biol Chem 284, no. 13 (March 27, 2009): 8692–8702. https://doi.org/10.1074/jbc.M806919200.Full Text Link to Item
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Wang, Jun, S Gary Mansfield, Colette A. Cote, Ping Du Jiang, Ke Weng, Marcelo J. A. Amar, Bryan H. Brewer, et al. “Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo.” Mol Ther 17, no. 2 (February 2009): 343–51. https://doi.org/10.1038/mt.2008.260.Full Text Link to Item
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Mauger, David M., Carolina Lin, and Mariano A. Garcia-Blanco. “hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc.” Mol Cell Biol 28, no. 17 (September 2008): 5403–19. https://doi.org/10.1128/MCB.00739-08.Full Text Link to Item
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Seth, Puneet, Heather B. Miller, Erika L. Lasda, James L. Pearson, and Mariano A. Garcia-Blanco. “Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc.” J Biol Chem 283, no. 15 (April 11, 2008): 10058–67. https://doi.org/10.1074/jbc.M800087200.Full Text Link to Item
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Pearson, James L., Timothy J. Robinson, Manuel J. Muñoz, Alberto R. Kornblihtt, and Mariano A. Garcia-Blanco. “Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mRNA processing.” J Biol Chem 283, no. 12 (March 21, 2008): 7949–61. https://doi.org/10.1074/jbc.M709402200.Full Text Link to Item
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Eis, P. S., and M. A. Garcia-Blanco. “Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay.” Methods in Molecular Biology 488 (2008): 279–318. https://doi.org/10.1007/978-1-60327-475-3-20.Full Text
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Eis, Peggy S., and Mariano A. Garcia-Blanco. “Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay.” Methods Mol Biol 488 (2008): 279–318. https://doi.org/10.1007/978-1-60327-475-3_20.Full Text Link to Item
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Oltean, Sebastian, Phillip G. Febbo, and Mariano A. Garcia-Blanco. “Dunning rat prostate adenocarcinomas and alternative splicing reporters: powerful tools to study epithelial plasticity in prostate tumors in vivo.” Clin Exp Metastasis 25, no. 6 (2008): 611–19. https://doi.org/10.1007/s10585-008-9186-y.Full Text Link to Item
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Gregory, Simon G., Silke Schmidt, Puneet Seth, Jorge R. Oksenberg, John Hart, Angela Prokop, Stacy J. Caillier, et al. “Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.” Nat Genet 39, no. 9 (September 2007): 1083–91. https://doi.org/10.1038/ng2103.Full Text Link to Item
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Simarro, Maria, David Mauger, Kirsten Rhee, Miguel A. Pujana, Nancy L. Kedersha, Satoshi Yamasaki, Michael E. Cusick, Marc Vidal, Mariano A. Garcia-Blanco, and Paul Anderson. “Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.” Proc Natl Acad Sci U S A 104, no. 27 (July 3, 2007): 11370–75. https://doi.org/10.1073/pnas.0704964104.Full Text Link to Item
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Bonano, Vivian I., Sebastian Oltean, and Mariano A. Garcia-Blanco. “A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice.” Nat Protoc 2, no. 9 (2007): 2166–81. https://doi.org/10.1038/nprot.2007.292.Full Text Link to Item
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Overman, R Glenn, Anthony L. Llorens, Michael L. Greenberg, Mariano A. Garcia-Blanco, and Georgia D. Tomaras. “Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression.” Open Virol J 1 (2007): 1–7. https://doi.org/10.2174/1874357900701010001.Full Text Link to Item
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Bonano, Vivian I., Sebastian Oltean, Robert M. Brazas, and Mariano A. Garcia-Blanco. “Imaging the alternative silencing of FGFR2 exon IIIb in vivo.” Rna 12, no. 12 (December 2006): 2073–79. https://doi.org/10.1261/rna.248506.Full Text Link to Item
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Oltean, Sebastian, Brian S. Sorg, Todd Albrecht, Vivian I. Bonano, Robert M. Brazas, Mark W. Dewhirst, and Mariano A. Garcia-Blanco. “Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity.” Proc Natl Acad Sci U S A 103, no. 38 (September 19, 2006): 14116–21. https://doi.org/10.1073/pnas.0603090103.Full Text Link to Item
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Sánchez-Alvarez, Miguel, Aaron C. Goldstrohm, Mariano A. Garcia-Blanco, and Carlos Suñé. “Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions.” Mol Cell Biol 26, no. 13 (July 2006): 4998–5014. https://doi.org/10.1128/MCB.01991-05.Full Text Link to Item
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Baraniak, Andrew P., Jing R. Chen, and Mariano A. Garcia-Blanco. “Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice.” Mol Cell Biol 26, no. 4 (February 2006): 1209–22. https://doi.org/10.1128/MCB.26.4.1209-1222.2006.Full Text Link to Item
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Dressman, Holly K., Lise Barley-Maloney, Laura-Leigh Rowlette, Paul F. Agris, and Mariano A. Garcia-Blanco. “Assessing incomplete deprotection of microarray oligonucleotides in situ.” Nucleic Acids Res 34, no. 19 (2006): e131. https://doi.org/10.1093/nar/gkl713.Full Text Link to Item
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Garcia-Blanco, Mariano A. “Alternative splicing: therapeutic target and tool.” Prog Mol Subcell Biol 44 (2006): 47–64. https://doi.org/10.1007/978-3-540-34449-0_3.Full Text Link to Item
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Garcia-Blanco, Mariano A. “Methods for the study of alternative splicing.” Methods 37, no. 4 (December 2005): 289–91. https://doi.org/10.1016/j.ymeth.2005.10.001.Full Text Link to Item
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Natalizio, Barbara J., and Mariano A. Garcia-Blanco. “In vitro coupled transcription splicing.” Methods 37, no. 4 (December 2005): 314–22. https://doi.org/10.1016/j.ymeth.2005.07.013.Full Text Link to Item
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Rodriguez-Martin, Teresa, Mariano A. Garcia-Blanco, S Gary Mansfield, Andrew C. Grover, Michael Hutton, Qingming Yu, Jianhua Zhou, Brian H. Anderton, and Jean-Marc Gallo. “Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies.” Proc Natl Acad Sci U S A 102, no. 43 (October 25, 2005): 15659–64. https://doi.org/10.1073/pnas.0503150102.Full Text Link to Item
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Garcia-Blanco, Mariano A. “Making antisense of splicing.” Curr Opin Mol Ther 7, no. 5 (October 2005): 476–82.Link to Item
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Florez, Paola M., October M. Sessions, Eric J. Wagner, Matthias Gromeier, and Mariano A. Garcia-Blanco. “The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation.” J Virol 79, no. 10 (May 2005): 6172–79. https://doi.org/10.1128/JVI.79.10.6172-6179.2005.Full Text Link to Item
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Wagner, Eric J., Andrew P. Baraniak, October M. Sessions, David Mauger, Eric Moskowitz, and Mariano A. Garcia-Blanco. “Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb.” J Biol Chem 280, no. 14 (April 8, 2005): 14017–27. https://doi.org/10.1074/jbc.M414492200.Full Text Link to Item
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Robson-Dixon, Nicole D., and Mariano A. Garcia-Blanco. “MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb.” J Biol Chem 279, no. 28 (July 9, 2004): 29075–84. https://doi.org/10.1074/jbc.M312747200.Full Text Link to Item
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Garcia-Blanco, Mariano A., Andrew P. Baraniak, and Erika L. Lasda. “Alternative splicing in disease and therapy.” Nat Biotechnol 22, no. 5 (May 2004): 535–46. https://doi.org/10.1038/nbt964.Full Text Link to Item
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Shan, Siqing, Nicole D. Robson, Yiting Cao, Tong Qiao, Chuan Y. Li, Christopher D. Kontos, Mariano Garcia-Blanco, and Mark W. Dewhirst. “Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.” Faseb J 18, no. 2 (February 2004): 326–28. https://doi.org/10.1096/fj.03-0765fje.Full Text Link to Item
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Wollerton, Matthew C., Clare Gooding, Eric J. Wagner, Mariano A. Garcia-Blanco, and Christopher W. J. Smith. “Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay.” Mol Cell 13, no. 1 (January 16, 2004): 91–100. https://doi.org/10.1016/s1097-2765(03)00502-1.Full Text Link to Item
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Wagner, Eric J., Andrea Baines, Todd Albrecht, Robert M. Brazas, and Mariano A. Garcia-Blanco. “Imaging alternative splicing in living cells.” Methods Mol Biol 257 (2004): 29–46. https://doi.org/10.1385/1-59259-750-5:029.Full Text Link to Item
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Baraniak, Andrew P., Erika L. Lasda, Eric J. Wagner, and Mariano A. Garcia-Blanco. “A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements.” Mol Cell Biol 23, no. 24 (December 2003): 9327–37. https://doi.org/10.1128/mcb.23.24.9327-9337.2003.Full Text Link to Item
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Garcia-Blanco, Mariano A. “Mending the message.” Nat Biotechnol 21, no. 12 (December 2003): 1448–49. https://doi.org/10.1038/nbt1203-1448.Full Text Link to Item
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Wagner, Eric J., Michelle L. Curtis, Nicole D. Robson, Andrew P. Baraniak, Peggy S. Eis, and Mariano A. Garcia-Blanco. “Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay.” Rna 9, no. 12 (December 2003): 1552–61. https://doi.org/10.1261/rna.5840803.Full Text Link to Item
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Mansfield, S Gary, Rebecca Hawkins Clark, M. Puttaraju, Jolanta Kole, Jonathan A. Cohn, Lloyd G. Mitchell, and Mariano A. Garcia-Blanco. “5' exon replacement and repair by spliceosome-mediated RNA trans-splicing.” Rna 9, no. 10 (October 2003): 1290–97. https://doi.org/10.1261/rna.5101903.Full Text Link to Item
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Chao, Hengjun, S Gary Mansfield, Robert C. Bartel, Suja Hiriyanna, Lloyd G. Mitchell, Mariano A. Garcia-Blanco, and Christopher E. Walsh. “Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing.” Nat Med 9, no. 8 (August 2003): 1015–19. https://doi.org/10.1038/nm900.Full Text Link to Item
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Garcia-Blanco, Mariano A. “Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.” J Clin Invest 112, no. 4 (August 2003): 474–80. https://doi.org/10.1172/JCI19462.Full Text Link to Item
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Colón-Ramos, Daniel A., Jeffrey L. Salisbury, Mark A. Sanders, Shailesh M. Shenoy, Robert H. Singer, and Mariano A. García-Blanco. “Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of beta2-tubulin mRNA in Chlamydomonas reinhardtii.” Dev Cell 4, no. 6 (June 2003): 941–52. https://doi.org/10.1016/s1534-5807(03)00163-1.Full Text Link to Item
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Lund, Lars H., Britta Wahren, and Mariano A. Garcia-Blanco. “A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo.” J Gen Virol 84, no. Pt 3 (March 2003): 603–6. https://doi.org/10.1099/vir.0.18645-0.Full Text Link to Item
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Mistry, Neville, Whitney Harrington, Erika Lasda, Eric J. Wagner, and Mariano A. Garcia-Blanco. “Of urchins and men: evolution of an alternative splicing unit in fibroblast growth factor receptor genes.” Rna 9, no. 2 (February 2003): 209–17. https://doi.org/10.1261/rna.2470903.Full Text Link to Item
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Wagner, E. J., and M. A. Garcia-Blanco. “Erratum: RNAi-mediated PTB depletion leads to enhanced exon definition (Molecular Cell (October 2002) 10 (943-949).” Molecular Cell 10, no. 6 (December 1, 2002): 1535. https://doi.org/10.1016/S1097-2765(02)00792-X.Full Text
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Wagner, Eric J., and Mariano A. Garcia-Blanco. “RNAi-mediated PTB depletion leads to enhanced exon definition.” Mol Cell 10, no. 4 (October 2002): 943–49. https://doi.org/10.1016/s1097-2765(02)00645-7.Full Text Link to Item
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Niranjanakumari, Somashe, Erika Lasda, Robert Brazas, and Mariano A. Garcia-Blanco. “Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo.” Methods 26, no. 2 (February 2002): 182–90. https://doi.org/10.1016/S1046-2023(02)00021-X.Full Text Link to Item
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Liu, Xiaoming, Qinshi Jiang, S Gary Mansfield, M. Puttaraju, Yulong Zhang, Weihong Zhou, Jonathan A. Cohn, Mariano A. Garcia-Blanco, Lloyd G. Mitchell, and John F. Engelhardt. “Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing.” Nat Biotechnol 20, no. 1 (January 2002): 47–52. https://doi.org/10.1038/nbt0102-47.Full Text Link to Item
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Goldstrohm, A. C., T. R. Albrecht, C. Suñé, M. T. Bedford, and M. A. Garcia-Blanco. “The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1.” Mol Cell Biol 21, no. 22 (November 2001): 7617–28. https://doi.org/10.1128/MCB.21.22.7617-7628.2001.Full Text Link to Item
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Goldstrohm, A. C., A. L. Greenleaf, and M. A. Garcia-Blanco. “Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing.” Gene 277, no. 1–2 (October 17, 2001): 31–47. https://doi.org/10.1016/s0378-1119(01)00695-3.Full Text Link to Item
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Puttaraju, M., J. DiPasquale, C. C. Baker, L. G. Mitchell, and M. A. Garcia-Blanco. “Messenger RNA repair and restoration of protein function by spliceosome-mediated RNA trans-splicing.” Mol Ther 4, no. 2 (August 2001): 105–14. https://doi.org/10.1006/mthe.2001.0426.Full Text Link to Item
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Wagner, E. J., and M. A. Garcia-Blanco. “Polypyrimidine tract binding protein antagonizes exon definition.” Mol Cell Biol 21, no. 10 (May 2001): 3281–88. https://doi.org/10.1128/MCB.21.10.3281-3288.2001.Full Text Link to Item
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Puttaraju, M., S. F. Jamison, S. G. Mansfield, M. A. Garcia-Blanco, and L. G. Mitchell. “Erratum: Spliceosome-mediated RNA trans-splicing as a tool for gene therapy (Nature Biotechnol. (1999) 17 (246-252)).” Nature Biotechnology 19, no. 3 (January 1, 2001): 277. https://doi.org/10.1038/85741.Full Text
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Mansfield, S. G., J. Kole, M. Puttaraju, C. C. Yang, M. A. Garcia-Blanco, J. A. Cohn, and L. G. Mitchell. “Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing.” Gene Ther 7, no. 22 (November 2000): 1885–95. https://doi.org/10.1038/sj.gt.3301307.Full Text Link to Item
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Bohne, J., S. E. Cole, C. Suñe, B. R. Lindman, V. D. Ko, T. F. Vogt, and M. A. Garcia-Blanco. “Expression analysis and mapping of the mouse and human transcriptional regulator CA150.” Mamm Genome 11, no. 10 (October 2000): 930–33. https://doi.org/10.1007/s003350010162.Full Text Link to Item
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Carstens, R. P., E. J. Wagner, and M. A. Garcia-Blanco. “An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein.” Mol Cell Biol 20, no. 19 (October 2000): 7388–7400. https://doi.org/10.1128/mcb.20.19.7388-7400.2000.Full Text Link to Item
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Ghosh, S., and M. A. Garcia-Blanco. “Coupled in vitro synthesis and splicing of RNA polymerase II transcripts.” Rna 6, no. 9 (September 2000): 1325–34. https://doi.org/10.1017/s1355838200992537.Full Text Link to Item
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Lindsey-Boltz, L. A., G. Chawla, N. Srinivasan, U. Vijayraghavan, and M. A. Garcia-Blanco. “The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.” Rna 6, no. 9 (September 2000): 1289–1305. https://doi.org/10.1017/s1355838200000327.Full Text Link to Item
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Suñé, C., A. C. Goldstrohm, J. Peng, D. H. Price, and M. A. Garcia-Blanco. “An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.” Virology 274, no. 2 (September 1, 2000): 356–66. https://doi.org/10.1006/viro.2000.0480.Full Text Link to Item
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Carty, S. M., A. C. Goldstrohm, C. Suñé, M. A. Garcia-Blanco, and A. L. Greenleaf. “Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II.” Proc Natl Acad Sci U S A 97, no. 16 (August 1, 2000): 9015–20. https://doi.org/10.1073/pnas.160266597.Full Text Link to Item
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Albrecht, T. R., L. H. Lund, and M. A. Garcia-Blanco. “Canine cyclin T1 rescues equine infectious anemia virus tat trans-activation in human cells.” Virology 268, no. 1 (March 1, 2000): 7–11. https://doi.org/10.1006/viro.1999.0141.Full Text Link to Item
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Suñé, C., and M. A. Garcia-Blanco. “Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner.” Mol Cell Biol 19, no. 7 (July 1999): 4719–28. https://doi.org/10.1128/mcb.19.7.4719.Full Text Link to Item
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Wagner, E. J., R. P. Carstens, and M. A. Garcia-Blanco. “A novel isoform ratio switch of the polypyrimidine tract binding protein.” Electrophoresis 20, no. 4–5 (April 1999): 1082–86. https://doi.org/10.1002/(SICI)1522-2683(19990101)20:4/5<1082::AID-ELPS1082>3.0.CO;2-#.Full Text Link to Item
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Liu, Y., C. Suñé, and M. A. Garcia-Blanco. “Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex.” Virology 255, no. 2 (March 15, 1999): 337–46. https://doi.org/10.1006/viro.1998.9585.Full Text Link to Item
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Puttaraju, M., S. F. Jamison, S. G. Mansfield, M. A. Garcia-Blanco, and L. G. Mitchell. “Spliceosome-mediated RNA trans-splicing as a tool for gene therapy.” Nat Biotechnol 17, no. 3 (March 1999): 246–52. https://doi.org/10.1038/6986.Full Text Link to Item
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Lindsey, L. A., and M. A. Garcia-Blanco. “Prespliceosome and spliceosome isolation and analysis.” Methods Mol Biol 118 (1999): 351–64. https://doi.org/10.1385/1-59259-676-2:351.Full Text Link to Item
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Puttaruju, M., S. F. Jamison, G. Mansfield, M. A. Garcia-Blanco, and L. G. Mitchell. “Erratum: Spliceosome-mediated RNA trans-splicing as a tool for gene therapy (Nature Biotechnology).” Nature Biotechnology 17, no. 6 (January 1, 1999): 602. https://doi.org/10.1038/9922.Full Text
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Lindsey, L. A., and M. A. Garcia-Blanco. “Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p.” J Biol Chem 273, no. 49 (December 4, 1998): 32771–75. https://doi.org/10.1074/jbc.273.49.32771.Full Text Link to Item
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Cao, W., and M. A. Garcia-Blanco. “A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding.” J Biol Chem 273, no. 32 (August 7, 1998): 20629–35. https://doi.org/10.1074/jbc.273.32.20629.Full Text Link to Item
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Carstens, R. P., W. L. McKeehan, and M. A. Garcia-Blanco. “An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing.” Mol Cell Biol 18, no. 4 (April 1998): 2205–17. https://doi.org/10.1128/mcb.18.4.2205.Full Text Link to Item
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Bepler, G., K. M. Fong, B. E. Johnson, K. C. O’Briant, L. A. Daly, P. V. Zimmerman, M. A. Garcia-Blanco, and B. Peterson. “Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer.” Cancer Detect Prev 22, no. 1 (1998): 14–19.Link to Item
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Carstens, R. P., J. V. Eaton, H. R. Krigman, P. J. Walther, and M. A. Garcia-Blanco. “Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer.” Oncogene 15, no. 25 (December 18, 1997): 3059–65. https://doi.org/10.1038/sj.onc.1201498.Full Text Link to Item
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Cao, W., S. F. Jamison, and M. A. Garcia-Blanco. “Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.” Rna 3, no. 12 (December 1997): 1456–67.Link to Item
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Bohjanen, P. R., Y. Liu, and M. A. Garcia-Blanco. “TAR RNA decoys inhibit tat-activated HIV-1 transcription after preinitiation complex formation.” Nucleic Acids Res 25, no. 22 (November 15, 1997): 4481–86. https://doi.org/10.1093/nar/25.22.4481.Full Text Link to Item
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Suñé, C., T. Hayashi, Y. Liu, W. S. Lane, R. A. Young, and M. A. Garcia-Blanco. “CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription.” Mol Cell Biol 17, no. 10 (October 1997): 6029–39. https://doi.org/10.1128/mcb.17.10.6029.Full Text Link to Item
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Bohjanen, P. R., R. A. Colvin, M. Puttaraju, M. D. Been, and M. A. Garcia-Blanco. “A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription.” Nucleic Acids Res 24, no. 19 (October 1, 1996): 3733–38. https://doi.org/10.1093/nar/24.19.3733.Full Text Link to Item
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Pasman, Z., M. D. Been, and M. A. Garcia-Blanco. “Exon circularization in mammalian nuclear extracts.” Rna 2, no. 6 (June 1996): 603–10.Link to Item
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Pasman, Z., and M. A. Garcia-Blanco. “The 5' and 3' splice sites come together via a three dimensional diffusion mechanism.” Nucleic Acids Research 24, no. 9 (May 1996): 1638–45. https://doi.org/10.1093/nar/24.9.1638.Full Text
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Suñé, C., and M. A. García-Blanco. “Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat.” J Virol 69, no. 10 (October 1995): 6572–76. https://doi.org/10.1128/JVI.69.10.6572-6576.1995.Full Text Link to Item
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Roscigno, R. F., and M. A. Garcia-Blanco. “SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.” Rna (New York, N.Y.) 1, no. 7 (September 1995): 692–706.
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Jamison, S. F., Z. Pasman, J. Wang, C. Will, R. Lührmann, J. L. Manley, and M. A. Garcia-Blanco. “U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.” Nucleic Acids Research 23, no. 16 (August 1995): 3260–67. https://doi.org/10.1093/nar/23.16.3260.Full Text
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Lindsey, L. A., A. J. Crow, and M. A. Garcia-Blanco. “A mammalian activity required for the second step of pre-messenger RNA splicing.” J Biol Chem 270, no. 22 (June 2, 1995): 13415–21. https://doi.org/10.1074/jbc.270.22.13415.Full Text Link to Item
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Suñé, C., and M. A. García-Blanco. “Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.” J Virol 69, no. 5 (May 1995): 3098–3107. https://doi.org/10.1128/JVI.69.5.3098-3107.1995.Full Text Link to Item
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Garcia-Blanco, M. A., D. D. Miller, and M. P. Sheetz. “Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains.” The Journal of Cell Biology 128, no. 1–2 (January 1995): 15–27. https://doi.org/10.1083/jcb.128.1.15.Full Text
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Samuels, M. E., D. Bopp, R. A. Colvin, R. F. Roscigno, M. A. Garcia-Blanco, and P. Schedl. “RNA binding by Sxl proteins in vitro and in vivo.” Mol Cell Biol 14, no. 7 (July 1994): 4975–90. https://doi.org/10.1128/mcb.14.7.4975.Full Text Link to Item
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Bepler, G., and M. A. Garcia-Blanco. “Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer.” Proc Natl Acad Sci U S A 91, no. 12 (June 7, 1994): 5513–17. https://doi.org/10.1073/pnas.91.12.5513.Full Text Link to Item
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Kohtz, J. D., S. F. Jamison, C. L. Will, P. Zuo, R. Lührmann, M. A. Garcia-Blanco, and J. L. Manley. “Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.” Nature 368, no. 6467 (March 10, 1994): 119–24. https://doi.org/10.1038/368119a0.Full Text Link to Item
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Roscigno, R. F., M. Weiner, and M. A. Garcia-Blanco. “A mutational analysis of the polypyrimidine tract of introns. Effects of sequence differences in pyrimidine tracts on splicing.” J Biol Chem 268, no. 15 (May 25, 1993): 11222–29.Link to Item
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Colvin, R. A., S. W. White, M. A. Garcia-Blanco, and D. W. Hoffman. “Structural features of an RNA containing the CUGGGA loop of the human immunodeficiency virus type 1 trans-activation response element.” Biochemistry 32, no. 4 (February 2, 1993): 1105–12. https://doi.org/10.1021/bi00055a016.Full Text Link to Item
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Hoffman, D. W., R. A. Colvin, M. A. Garcia-Blanco, and S. W. White. “Structural features of the trans-activation response RNA element of equine infectious anemia virus.” Biochemistry 32, no. 4 (February 2, 1993): 1096–1104. https://doi.org/10.1021/bi00055a015.Full Text Link to Item
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Jamison, S. F., A. Crow, and M. A. Garcia-Blanco. “The spliceosome assembly pathway in mammalian extracts.” Mol Cell Biol 12, no. 10 (October 1992): 4279–87. https://doi.org/10.1128/mcb.12.10.4279.Full Text Link to Item
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Jamison, S. F., and M. A. Garcia-Blanco. “An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract.” Proc Natl Acad Sci U S A 89, no. 12 (June 15, 1992): 5482–86. https://doi.org/10.1073/pnas.89.12.5482.Full Text Link to Item
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Rodríguez-Pérez, J., J. R. Rodríguez-Medina, M. A. García-Blanco, and G. V. Hillyer. “Fasciola hepatica: molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein.” Exp Parasitol 74, no. 4 (June 1992): 400–407. https://doi.org/10.1016/0014-4894(92)90202-l.Full Text Link to Item
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Colvin, R. A., and M. A. Garcia-Blanco. “Unusual structure of the human immunodeficiency virus type 1 trans-activation response element.” J Virol 66, no. 2 (February 1992): 930–35. https://doi.org/10.1128/JVI.66.2.930-935.1992.Full Text Link to Item
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Bothwell, A. L., D. W. Ballard, W. M. Philbrick, G. Lindwall, S. E. Maher, M. M. Bridgett, S. F. Jamison, and M. A. Garcia-Blanco. “Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain.” J Biol Chem 266, no. 36 (December 25, 1991): 24657–63.Link to Item
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Garcia-Blanco, M. A., and B. R. Cullen. “Molecular basis of latency in pathogenic human viruses.” Science 254, no. 5033 (November 8, 1991): 815–20. https://doi.org/10.1126/science.1658933.Full Text Link to Item
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Gil, A., P. A. Sharp, S. F. Jamison, and M. A. Garcia-Blanco. “Characterization of cDNAs encoding the polypyrimidine tract-binding protein.” Genes Dev 5, no. 7 (July 1991): 1224–36. https://doi.org/10.1101/gad.5.7.1224.Full Text Link to Item
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Marciniak, R. A., M. A. Garcia-Blanco, and P. A. Sharp. “Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus.” Proceedings of the National Academy of Sciences of the United States of America 87, no. 9 (May 1990): 3624–28. https://doi.org/10.1073/pnas.87.9.3624.Full Text
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Garcia-Blanco, M. A., G. J. Anderson, J. Beggs, and P. A. Sharp. “A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein.” Proc Natl Acad Sci U S A 87, no. 8 (April 1990): 3082–86. https://doi.org/10.1073/pnas.87.8.3082.Full Text Link to Item
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Garcia-Blanco, M. A., J. A. Porter, E. D. Morrison, and C. D. Stiles. “The beta-interferon-mediated antimitogenic state resembles the anti-viral state.” Oncogene Res 5, no. 4 (1990): 323–28.Link to Item
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García-Blanco, M. A., S. F. Jamison, and P. A. Sharp. “Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.” Genes Dev 3, no. 12A (December 1989): 1874–86. https://doi.org/10.1101/gad.3.12a.1874.Full Text Link to Item
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García-Blanco, M. A., R. G. Clerc, and P. A. Sharp. “The DNA-binding homeo domain of the Oct-2 protein.” Genes Dev 3, no. 6 (June 1989): 739–45. https://doi.org/10.1101/gad.3.6.739.Full Text Link to Item
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Garcia-Blanco, M. A., P. Lengyel, E. Morrison, C. Brownlee, C. D. Stiles, M. Rutherford, G. Hannigan, and B. R. Williams. “Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor.” Mol Cell Biol 9, no. 3 (March 1989): 1060–68. https://doi.org/10.1128/mcb.9.3.1060.Full Text Link to Item
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Arroyo, J. I., S. A. Apperson, C. B. Cropp, B. J. Marafino, T. P. Monath, R. B. Tesh, R. E. Shope, and M. A. Garcia-Blanco. “Effect of human gamma interferon on yellow fever virus infection.” Am J Trop Med Hyg 38, no. 3 (May 1988): 647–50.Link to Item
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Samanta, H., D. A. Engel, H. M. Chao, A. Thakur, M. A. García-Blanco, and P. Lengyel. “Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene.” J Biol Chem 261, no. 25 (September 5, 1986): 11849–58.Link to Item
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García-Blanco, M. A., P. K. Ghosh, B. M. Jayaram, S. Ivory, P. Lebowitz, and P. Lengyel. “Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40.” J Virol 53, no. 3 (March 1985): 893–98. https://doi.org/10.1128/JVI.53.3.893-898.1985.Full Text Link to Item
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Craft, J. E., R. L. Grodzicki, M. Shrestha, D. K. Fischer, M. García-Blanco, and A. C. Steere. “The antibody response in Lyme disease.” Yale J Biol Med 57, no. 4 (July 1984): 561–65.Link to Item
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Yoshie, O., I. S. Mellman, R. J. Broeze, M. Garcia-Blanco, and P. Lengyel. “Interferon action: effects of mouse alpha and beta interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1.” Cell Immunol 73, no. 1 (October 1982): 128–40. https://doi.org/10.1016/0008-8749(82)90441-5.Full Text Link to Item
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Rapaport, E., M. A. Garcia-Blanco, and P. C. Zamecnik. “Regulation of DNA replication in S phase nuclei by ATP and ADP pools.” Proc Natl Acad Sci U S A 76, no. 4 (April 1979): 1643–47. https://doi.org/10.1073/pnas.76.4.1643.Full Text Link to Item
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Hillyer, G. V., A. del Llano de Díaz, and M. García-Blanco. “A new approach to the study of immunity to schistosomes.” Bol Asoc Med P R 67, no. 12 (December 1975): 381–85.Link to Item
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GARCIA BLANCO, M. A. “[Intestinal lymphosarcomas].” Rev Clin Esp 40, no. 1 (January 15, 1951): 29–34.Link to Item
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GARCIA BLANCO, M. A. “[Histology of lymphosarcomas].” Laboratorio 10, no. 60 (December 1950): 501–9.Link to Item
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GARCIA BLANCO, M. A. “[Considerations on the histogenesis of lymphosarcoma].” Laboratorio 10, no. 59 (November 1950): 401–9.Link to Item
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NAVARRO-MARTIN, A., and M. A. GARCIA BLANCO. “[Finding of so-called L E cells in a pneumonitis focus before death from acute lupus erythematosus].” Rev Clin Esp 37, no. 4 (May 31, 1950): 253–56.Link to Item
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Book Sections
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Barrows, N. J., S. S. Bradrick, K. Bidet, A. Anwar, A. M. Ward, S. F. Jamison, B. Levitt, C. Le Sommer, and M. A. Garcia-Blanco. “The interface between dengue virus and the human host.” In Dengue and Dengue Hemorrhagic Fever: Second Edition, 406–24, 2014.
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Wagner, E. J., R. P. Carstens, and M. A. Garcia-Blanco. “A novel isoform ratio switch of the polypyrimidine tract binding protein.” In From Genome to Proteome: Advances in the Practice & Application of Proteomics, 502–6, 2007. https://doi.org/10.1002/9783527613489.ch65.Full Text
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