Gerald Edward Archer
Assistant Professor of Neurosurgery

My current research focus involves the delivery of therapeutic agents for the treatment of central nervous system neoplasia. Utilizing athymic rat models of central nervous system neoplasia I am investigating compartmental approaches to increase therapeutic efficacy of chemotherapeutic agents and immunoconjugates. Preclinical testing in athymic rats of intrathecal administration of melphalan and 4-hydroperoxycyclophosphamide have resulted in the FDA granting investigational new drug protocols for the treatment of neoplastic meningitis using these two agents. I am also currently involved with the selective intraarterial administration of alkylator resistance modulators to treat intraparechymal brain tumors which are resistant to conventional alkylator therapy. I am also working in collaboration with Dr. Darell Bigner on the characterization of MAbs that react with the epidermal growth factor receptor variant III mutant, a tumor specific antigen.

Current Appointments & Affiliations

Contact Information

  • 208 Sands, Durham, NC 27710
  • Box 3050 Med Ctr, Durham, NC 27710

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