Overview
My research laboratory uses physics-based computational tools to provide fundamental, molecular-level understanding of a diverse range of biological and soft-material systems, with the aim of discovering new phenomena and developing new technologies. The methods we use or develop are largely based on statistical mechanics, molecular modeling and simulations, stochastic dynamics, coarse-graining, bioinformatics, machine learning, and polymer/colloidal physics. Our current research interests fall within four main themes: genome organization and regulation; polymer-nanoparticle composites; viral-DNA-packaging; and DNA nanotechnology. Please visit our website for more details about each of these research projects.
Current Appointments & Affiliations
Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
·
2021 - Present
Thomas Lord Department of Mechanical Engineering and Materials Science,
Pratt School of Engineering
Professor of Chemistry
·
2022 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor of Biomedical Engineering
·
2024 - Present
Biomedical Engineering,
Pratt School of Engineering
Recent Publications
Modular programming of interaction and geometric specificity enables assembly of complex DNA origami nanostructures.
Journal Article Nature communications · December 2025 Self-assembly of nanoscale building blocks with programmable geometries and interactions offers a powerful route to engineer materials that mimic the complexity of biological structures. DNA origami provides an exceptional platform for this purpose, enabli ... Full text CiteAcoustically seeded fabrication of a DNA tesseract into a conductive wire.
Journal Article Nucleic acids research · November 2025 Assembly of DNA nanostructures to sub-millimetre scales is expected to have significant potential for applications in materials science and medicine. One approach to control nanostructure growth is through using acoustic waves to create pressure nodes for ... Full text CiteDynamic DNA superstructures with emergent functions.
Journal Article Nanoscale horizons · October 2025 DNA nanotechnology enables the precise construction of intricate nanoscale structures. Over the past two decades, significant progress has been made in incorporating dynamic functionalities into these nanostructures. Concurrently, innovative strategies hav ... Full text CiteRecent Grants
Collaborative Research: DMREF: Architecting DNA nanodevices into metamaterials, transducing materials, and assembling materials
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2023 - 2027Programmable Mesoscale Self-Assembly at Nanopatterned Surfaces.
ResearchPrincipal Investigator · Awarded by Department of Energy · 2020 - 2027Understanding the supramolecular nature of the ligand-nanocrystal interlayer
ResearchPrincipal Investigator · Awarded by University of California - San Diego · 2024 - 2027View All Grants
Education, Training & Certifications
University of Notre Dame ·
2003
Ph.D.
Indian Institute of Technology, Delhi (India) ·
1998
B.Tech.