Scholars@Duke
Gaurav Arya

Gaurav Arya

Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
Thomas Lord Department of Mechanical Engineering and Materials Science
gaurav.arya@duke.edu
3383 Fitzpatrick Center (CIEMAS), Duke University, Durham, NC 27708
144 Hudson Hall, Box 90300, Duke University, Durham, NC 27708

Featured Works

Versatile computer-aided design of free-form DNA nanostructures and assemblies.

Journal article Science advances · July 2023 Featured Publication Recent advances in structural DNA nanotechnology have been facilitated by design tools that continue to push the limits of structural complexity while simplifying an often-tedious design process. We recently introduced the software MagicDNA, which enables ... Full text Cite

Discovery of two-dimensional binary nanoparticle superlattices using global Monte Carlo optimization.

Journal article Nature communications · December 2022 Featured Publication Binary nanoparticle (NP) superlattices exhibit distinct collective plasmonic, magnetic, optical, and electronic properties. Here, we computationally demonstrate how fluid-fluid interfaces could be used to self-assemble binary systems of NPs into 2D superla ... Full text Cite

Reconfigurable Chirality of DNA-Bridged Nanorod Dimers.

Journal article ACS nano · August 2021 Featured Publication Gold nanorods assembled in a side-by-side chiral configuration have potential applications in sensing due to their strong chiroptical surface plasmon resonances. Recent experiments have shown that dimers of gold nanorods bridged by double-stranded DNA exhi ... Full text Cite

Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor.

Journal article Nucleic acids research · June 2021 Featured Publication Double-stranded DNA viruses package their genomes into pre-assembled capsids using virally-encoded ASCE ATPase ring motors. We present the first atomic-resolution crystal structure of a multimeric ring form of a viral dsDNA packaging motor, the ATPase of t ... Full text Cite

Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation.

Journal article Proceedings of the National Academy of Sciences of the United States of America · April 2021 Featured Publication Many viruses utilize ringed packaging ATPases to translocate double-stranded DNA into procapsids during replication. A critical step in the mechanochemical cycle of such ATPases is ATP binding, which causes a subunit within the motor to grip DNA tightly. H ... Full text Cite

Analytical van der Waals interaction potential for faceted nanoparticles.

Journal article Nanoscale horizons · December 2020 Featured Publication Our ability to synthesize faceted nanoparticles of tunable shapes and sizes has opened up many intriguing applications of such particles. However, our progress in understanding, modeling, and simulating their collective rheology, phase behavior, and self-a ... Full text Cite

Dynamic DNA nanotechnology: Toward functional nanoscale devices

Journal article Nanoscale Horizons · February 1, 2020 Featured Publication Dynamic DNA nanotechnology involves the creation of nanoscale devices made of DNA whose primary function arises from their ability to undergo controlled motion or reconfiguration. In the past two decades, dynamic DNA nanotechnology has evolved to the point ... Full text Cite

Interfacial Assembly of Tunable Anisotropic Nanoparticle Architectures.

Journal article ACS nano · April 2019 Featured Publication We propose a strategy for assembling spherical nanoparticles (NPs) into anisotropic architectures in a polymer matrix. The approach takes advantage of the interfacial tension between two mutually immiscible polymers forming a bilayer and differences in the ... Full text Cite

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α.

Journal article Nature communications · January 2018 Featured Publication The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is poorly understood. Here, we employ multimodal single-molecule Förster resonance energy transfer studies to reveal structural states and their interconversion kinetics ... Full text Cite

Conformational Dynamics of Mechanically Compliant DNA Nanostructures from Coarse-Grained Molecular Dynamics Simulations.

Journal article ACS nano · May 2017 Featured Publication Structural DNA nanotechnology, the assembly of rigid 3D structures of complex yet precise geometries, has recently been used to design dynamic, mechanically compliant nanostructures with tunable equilibrium conformations and conformational distributions. H ... Full text Cite