Georgia Doris Tomaras

Conference bioRxiv · April 4, 2025 Current SARS-CoV-2 vaccines have demonstrated robust induction of neutralizing antibodies and CD4+ T cell activation, however CD8+ responses are variable, and the duration of immunity and protection against variants are limited. Here we repurposed our DNA ... Full text Link to item Cite

Vaccination with a novel fractional escalating dose strategy improves early humoral responses with a novel germline targeting HIV vaccine (426.mod.core-C4b): Preliminary results from HVTN 301

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

Broadest binding antibody and cellular responses seen with a matched prime-boost polyvalent DNA plasmid vaccine in a comparative analysis of 13 HIV vaccine trials conducted worldwide

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

Pharmacokinetic interaction assessment of the HIV broadly neutralizing monoclonal antibody VRC07-523LS: A cross-protocol analysis of three phase 1 HIV prevention trials HVTN127/HPTN087, HVTN130/HPTN089 and HVTN136/HPTN092

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

Phase 1 dose-escalation trial to evaluate the safety, tolerability, pharmacokinetics and neutralization activity of PGDM1400LS in combination with VRC07-523LS and PGT121.414.LS in healthy participants without HIV (HVTN 140/HPTN 101)

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

HIV BG505 SOSIP.664 trimer with 3M-052-AF/alum induces broad and potent ADCC-mediating antibodies

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

A higher proportion of recent compared to historic HIV viruses are resistant to antibody-dependent cellular cytotoxicity mediated by monoclonal antibodies

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

Membrane-anchored HIV-1 Env trimer BG505 MD39.3 mRNA is immunogenic and can elicit tier 2 autologous neutralizing antibodies (HVTN 302)

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

HLA-B*07:02 associated with higher vaccine efficacy in the phase 2b Imbokodo trial among young cisgender women with increased likelihood of HIV acquisition in Southern Africa

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

HIV BG505 SOSIP.664 trimer with 3M-052-AF+alum induces a lasting IFN signature that correlates with the development of HIV-1 antibodies

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · October 2024 Link to item Cite

Safety and immunogenicity of a polyvalent DNA/polyvalent protein HIV vaccine with matched Env immunogens delivered as a prime-boost regimen or co-administered in adults without HIV

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 2024 Link to item Cite

V2-specific responses rescues SIV vaccine efficacy decreased by mucosal immunization with nanoparticles

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 2024 Link to item Cite

A tool for analyzing complex epitope binning data of monoclonal antibodies

Conference BIOPHYSICAL JOURNAL · February 8, 2024 Link to item Cite

Increased chemokine production is a hallmark of rhesus macaque natural killer cells mediating robust antibody-dependent cellular cytotoxicity

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 2023 Link to item Cite

Increased chemokine production is a hallmark of rhesus macaque natural killer cells mediating robust antibody-dependent cellular cytotoxicity

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 2023 Link to item Cite

Adjuvanted pox-protein vaccination elicits exceptional effector antibody and T cell responses, but does not protect against heterologous SHIV rectal challenge in rhesus macaques

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 2023 Link to item Cite

Oral and intranasal Ad5 influenza vaccination induces hemagglutinin-specific and influenza neutralizing antibodies in serum and milk of pregnant and lactating ferrets

Conference The Journal of Immunology · May 1, 2023 AbstractPregnant women and young children are at increased risk for severe influenza infection. While there are intramuscular (IM) inactivated influenza vaccines available to pregnant individuals, IM immuniz ... Full text Cite

TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms

Conference Gates Open Research · January 1, 2023 Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data, we h ... Full text Cite

Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques

Conference Frontiers in Immunology · January 1, 2023 Rhesus macaques (RMs) are a common pre-clinical model used to test HIV vaccine efficacy and passive immunization strategies. Yet, it remains unclear to what extent the Fc-Fc receptor (FcR) interactions impacting antiviral activities of antibodies in RMs re ... Full text Cite

Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens.

Conference EBioMedicine · October 2022 BACKGROUND: The identification of baseline host determinants that associate with robust HIV-1 vaccine-induced immune responses could aid HIV-1 vaccine development. We aimed to assess both the collective and relative performance of baseline characteristics ... Full text Link to item Cite

Immune correlates analysis of the Imbokodo HIV-1 vaccine efficacy trial

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · August 2022 Link to item Cite

Administration of the broadly neutralizing, CD4-binding site targeting antibody VRC07-523LS in dual- and triple-antibody combinations with 10-1074, PGT121, and/or PGDM1400: Impact on pharmacokinetics compared to VRC07-523LS administration alone

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · August 2022 Link to item Cite

First-in-human evaluation of safety and pharmacokinetics of intravenous or subcutaneous infusions of PGT121.141.LS, an anti-V3 HIV-1 broadly neutralizing antibody in healthy volunteers without HIV

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · August 2022 Link to item Cite

SARS-CoV-2 antibodies specific to the mesa and inner side of spike protein receptor binding domain maintain high affinities for both D614G and b.1.351 variants

Conference BIOPHYSICAL JOURNAL · February 11, 2022 Link to item Cite

Comparison of co-immunization of DNA and protein in the same anatomical sites and in contralateral sites to identify mechanisms of protective immune response

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · February 2021 Link to item Cite

Similar antibody responses to subtype C ALVAC-HIV/gp120 vaccine regimens using different adjuvants (MF59 vs. alum) but enhanced response rates and magnitude when ALVAC-HIV and gp120 were co-administered

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · February 2021 Link to item Cite

Sequence and structure guided HIV-1 clade C trimeric immunogen design to induce neutralizing and V1V2 directed antibody responses

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 2020 Link to item Cite

Mucosal vaccine efficacy against intrarectal SHIV acquisition independent of anti-Env antibody

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2019 Link to item Cite

ASCENT: Phase 2a, randomized, double-blind, placebo controlled study evaluating safety and immunogenicity of two HIV-1 prophylactic vaccine regimens comprising Ad26. Mos4. HIV and either clade C gp140 or bivalent gp140

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 1, 2019 Link to item Cite

Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost.

Conference J Virol · February 1, 2019 The use of heterologous immunization regimens and improved vector systems has led to increases in immunogenicity of HIV-1 vaccine candidates in nonhuman primates. In order to resolve interrelations between different delivery modalities, three different pox ... Full text Link to item Cite

Breadth of Human Monoclonal Antibodies Isolated from RTS,S/AS01 Vaccinees Binding to Plasmodium falciparum Circumsporozoite Protein Antigens

Conference Biophysical Journal · February 2019 Full text Cite

DNA and protein co-delivery vaccines using TLR-4-based adjuvants induce potent immune responses able to delay heterologous SIV acquisition

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2018 Link to item Cite

Impact of a TLR-5 Ligand as Adjuvant on Immunogenicity and Efficacy of a RhCMV-SIV Vaccine

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2018 Link to item Cite

V1V2 IgG and Antibody Fc Effector Functions in a Subtype C ALVAC-HIV and Bivalent Subtype C gp120/MF59 HIV-1 Vaccine Trial in South Africa

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Delayed and Repetitive Boosting of RV144 Vaccinees Improves Antiviral Immunity Associated With Correlates of HIV-1 Infection Risk

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Impact of Vaccine Regimen on Vaccine-induced Antibody Durability

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

HVTN114: A Phase 1 Trial to Evaluate Late Boosts With AIDSVAX B/E of Participants Previously Vaccinated With MVA/HIV62B in DNA/MVA or MVA Regimens

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Expansion of VH1-2*02 Env-specific B Cells in a Non-neutralizing HIV-1 Env Vaccine Regimen

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Increase in Env-specific Binding Antibody and CD4+T Cell-responses After Month 30 Boost of gp120/MF59 Delivered Alone or With ALVAC-HIV

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Safety and Immunogenicity of a pDNA Clade B Env Prime, rVSV Clade C Env Boost HIV-1 Vaccination Regimen in a Phase 1 Clinical Trial

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Vaccine-induced Activation of Inflammasome in Classical Monocytes and Th2 Cell Responses Correlates With Decreased Risk of SIVmac251 Acquisition

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Immune Responses to PENNVAX-GP (R) HIV DNA Vaccine Plus IL-12 Are Equivalent or Superior When Delivered by Intradermal vs. Intramuscular Electroporation

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Co-administration of 3 Doses of DNA/Protein Improves Antibody Responses to a Prime-boost Approach, but Needle-free Injection of DNA Shows No Benefit

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Primary Analysis of TRAVERSE: A Phase 1/2a Study to Assess Safety/Tolerability and Immunogenicity of 2 Different Prime/Boost HIV Vaccine Regimens

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

DNA-prime Induces Higher Magnitude Humoral Responses Than ALVAC-prime in HIV Vaccine Regimens With the Same Protein Boost

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Tetravalent Janssen Mosaic Ad26/Protein HIV Vaccine Shows Increased Clade C Env-specific CD4+T-cell and Antibody Responses Versus Trivalent Vaccine

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Oral MVA/protein HIV vaccination with a needle-free injector induces robust systemic and mucosal antibody responses in rhesus macaques

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 1, 2018 Link to item Cite

Long-term data from APPROACH: phase 1/2a randomized, double-blind, placebo-controlled study evaluating safety/tolerability and immunogenicity of vaccine regimens using combinations of Ad26.Mos.HIV, MVA-mosaic and gp140 envelope protein

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 1, 2018 Link to item Cite

Mucin-binding IgG: Characterizing a novel antibody effector function and discovery of a new Fc receptor

Conference JOURNAL OF MEDICAL PRIMATOLOGY · August 1, 2017 Link to item Cite

Effector CD4⁺ T cells can convert to a CD8⁺, MHCII-restricted T cell lineage

Conference JOURNAL OF IMMUNOLOGY · May 1, 2017 Link to item Cite

DNA/MVA HIV Vaccine Producing Virus-like Particles (VLPs) Is Well-tolerated and Induces Durable Functional Antibodies (Abs) in HVTN 094

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

MVA-expressed gp140 Boosts More Durable V1/V2 and gp120 Antibody Responses than gp120 Protein in Alum

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

The Relationship between Immune Responses to Tetanus Vaccine, Hepatitis B Vaccine and a Pox-protein HIV Vaccine Regimen

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

DNA and Protein Co-delivery Vaccines Using TLR-4-based Adjuvants Induce Potent Immune Responses Able to Delay Heterologous SIV Acquisition

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

EV06 Trial: Modulation of the Immunogenicity of the DNA-HIV-PT123 and AIDSVAX (R) B/E combination HIV vaccine in adult Ugandans by S. mansoni Infection

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

Comparing Different Priming Strategies to Optimize HIV Vaccine Antibody Responses: Results from HVTN 096/EV04 (NCT01799954)

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

Overview of Humoral and Cellular Immune Responses to HIV Vaccination

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

Protection from Rectal SHIV Infection Induced by Mucosal Vaccination with a Replication-competent VSV-HIV Chimera Delivering Env Trimers

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

Mucin-binding IgG: Characterizing a Novel Antibody Effector Function and Discovery of a New Fc Receptor

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2016 Link to item Cite

Meeting the "Go'' criteria: immunogenicity from HVTN100, a phase 1/2 randomized, double blind, placebo-controlled trial of clade C ALVAC-(R) (vCP2438) and Bivalent Subtype C gp120/MF59 (R) in HIV-uninfected South African adults

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 1, 2016 Link to item Cite

D-107 Vaccination establishes CXCR5+PD1+CD4+ peripheral blood germinal center T follicular helper cell relatives in humans

Conference JAIDS Journal of Acquired Immune Deficiency Syndromes · January 2016 Full text Cite

DNA AND PROTEIN CO-IMMUNIZATION IMPROVES THE MAGNITUDE, LONGEVITY, AND MUCOSAL DISSEMINATION OF IMMUNE RESPONSES

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2015 Link to item Cite

HIV-1-specific IgG antibody levels correlate with the presence of a specific HLA class II allele to impact acquisition and vaccine efficacy

Conference JOURNAL OF THE INTERNATIONAL AIDS SOCIETY · July 1, 2015 Full text Link to item Cite

A-112 DNA and Protein Co-immunization Improves the Magnitude, Longevity, and mucosal dissemination of Immune Responses

Conference JAIDS Journal of Acquired Immune Deficiency Syndromes · November 2014 Full text Cite

Association of HIV-1 Env Antibody Responses with Postnatal Mother-to-Child Transmission of HIV-1 via Breastfeeding.

Conference AIDS Res Hum Retroviruses · October 2014 Featured Publication Full text Link to item Cite

Induction of Antibodies with Long Variable Heavy Third Complementarity Determining Regions by Repetitive Boosting with AIDSVAX® B/E in RV144 Vaccinees.

Conference AIDS Res Hum Retroviruses · October 2014 Featured Publication Full text Link to item Cite

OPTIMIZATION OF SYSTEMIC AND MUCOSAL IMMUNE RESPONSES TO SIV AND HIV-1 ANTIGENS USING DIFFERENT PROTOCOLS OF DNA AND PROTEIN IMMUNIZATION IN MACAQUES

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2014 Link to item Cite

HIV ENV-SPECIFIC IGG3 RESPONSES ARE DIFFERENTIALLY ELICITED IN NONHUMAN PRIMATE BY ENV VACCINES WITH DIFFERENT ADJUVANTS

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2014 Featured Publication Link to item Cite

Microbicide-vaccine Combination Provides Significant Protection against Vaginal SHIV-162P3 Challenge in Cynomolgous Monkeys

Conference AIDS Research and Human Retroviruses · October 2014 Full text Cite

An HIV DNA Vaccine Delivered by Electroporation and Boosted by rVSV HIV-1 Gag Is Safe and Immunogenic in Healthy HIV-uninfected Adults

Conference AIDS Research and Human Retroviruses · October 2014 Full text Cite

No Increase in Activated T Cells and Limited Increase in Adenovirus-specific T Cells in Colon and Rectal Mucosa Following HIV-1 DNA/rAd5 Immunization

Conference AIDS Research and Human Retroviruses · October 2014 Full text Cite