Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Nephrology Fellowship, Medicine, Duke University School of Medicine 2011 - 2015
  • Internal Medicine Residency, Medicine, Duke University School of Medicine 2007 - 2010
  • MD./PhD., University of Maryland - Baltimore 2007
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2015 - 2018
• Recognition
• 

  In the News

  • APR 4, 2018

    Duke Med School Blog

    Five SoM Physician-Scientists Selected to Receive Strong Start Awards
• Research
• 

  Selected Grants

  • The Role of Interleukin-15 Receptor-alpha Variants in the Pathogenesis of FSGS awarded by National Institutes of Health 2017 - 2022
  • Exploring the Therapeutic Potential of Novel Discoveries in Hereditary Nephrotic Syndrome awarded by Northwestern University 2019 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hall, Gentzon, Brandon M. Lane, Kamal Khan, Igor Pediaditakis, Jianqiu Xiao, Guanghong Wu, Liming Wang, et al. “The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.” J Am Soc Nephrol 29, no. 8 (August 2018): 2110–22. https://doi.org/10.1681/ASN.2017121338.
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    • Varner, J. D., M. Chryst-Stangl, C. I. Esezobor, A. Solarin, G. Wu, B. Lane, G. Hall, et al. “Genetic testing for steroid-resistant-nephrotic syndrome in an outbred population.” Frontiers in Pediatrics 6 (January 1, 2018). https://doi.org/10.3389/fped.2018.00307.
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    • Hall, Gentzon, and Robert F. Spurney. “Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.” Kidney Int 92, no. 2 (August 2017): 283–85. https://doi.org/10.1016/j.kint.2017.03.045.
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    • Hall, Gentzon, Jonathan C. Routh, and Rasheed A. Gbadegesin. “Urinary Anomalies in 22q11.2 Deletion (DiGeorge syndrome): From Copy Number Variations to Single-Gene Determinants of Phenotype.” Am J Kidney Dis 70, no. 1 (July 2017): 8–10. https://doi.org/10.1053/j.ajkd.2017.03.017.
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    • Hall, Gentzon, Brandon Lane, Megan Chryst-Ladd, Guanghong Wu, Jen-Jar Lin, XueJun Qin, Elizabeth R. Hauser, and Rasheed Gbadegesin. “Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation.” Sci Rep 7 (January 6, 2017): 39933. https://doi.org/10.1038/srep39933.
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    • Elahi, Shan, Alison Homstad, Himani Vaidya, Jennifer Stout, Gentzon Hall, Guanghong Wu, Peter Conlon, et al. “Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.” Pediatr Nephrol 31, no. 2 (February 2016): 247–53. https://doi.org/10.1007/s00467-015-3203-6.
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    • Phelan, Paul J., Gentzon Hall, Delbert Wigfall, John Foreman, Shashi Nagaraj, Andrew F. Malone, Michelle P. Winn, David N. Howell, and Rasheed Gbadegesin. “Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation.” Clin Kidney J 8, no. 5 (October 2015): 538–42. https://doi.org/10.1093/ckj/sfv063.
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    • Gbadegesin, Rasheed A., Adebowale Adeyemo, Nicholas J. A. Webb, Larry A. Greenbaum, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arundhati Kale, et al. “HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.” J Am Soc Nephrol 26, no. 7 (July 2015): 1701–10. https://doi.org/10.1681/ASN.2014030247.
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    • Hall, Gentzon, and Rasheed A. Gbadegesin. “Translating genetic findings in hereditary nephrotic syndrome: the missing loops.” Am J Physiol Renal Physiol 309, no. 1 (July 1, 2015): F24–28. https://doi.org/10.1152/ajprenal.00683.2014.
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    • Hall, Gentzon, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Yangfan Liu, Edwin C. Oh, Liming Wang, et al. “A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.” J Am Soc Nephrol 26, no. 4 (April 2015): 831–43. https://doi.org/10.1681/ASN.2013101053.
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    • Gbadegesin, Rasheed A., Gentzon Hall, Adebowale Adeyemo, Nils Hanke, Irini Tossidou, James Burchette, Guanghong Wu, et al. “Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.” J Am Soc Nephrol 25, no. 9 (September 2014): 1991–2002. https://doi.org/10.1681/ASN.2013090976.
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    • Hall, Gentzon, Janelle Rowell, Federica Farinelli, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Alison Homstad, et al. “Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.” Am J Physiol Renal Physiol 306, no. 12 (June 15, 2014): F1442–50. https://doi.org/10.1152/ajprenal.00212.2013.
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    • Malone, A. F., P. J. Phelan, G. Hall, U. Cetincelik, A. Homstad, A. S. Alonso, R. Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.” Kidney International 86, no. 6 (January 1, 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.
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    • Eckel, J., P. J. Lavin, E. A. Finch, N. Mukerji, J. Burch, R. Gbadegesin, G. Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria (Journal of the American Society of Nephrology (2011) 22 (526-535)).” Journal of the American Society of Nephrology 24, no. 1 (December 28, 2013): 160. https://doi.org/10.1681/ASN.2012111069.
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    • Gbadegesin, Rasheed A., Patrick D. Brophy, Adebowale Adeyemo, Gentzon Hall, Indra R. Gupta, David Hains, Bartlomeij Bartkowiak, et al. “TNXB mutations can cause vesicoureteral reflux.” J Am Soc Nephrol 24, no. 8 (July 2013): 1313–22. https://doi.org/10.1681/ASN.2012121148.
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    • Gbadegesin, Rasheed A., Peter J. Lavin, Gentzon Hall, Bartlomiej Bartkowiak, Alison Homstad, Ruiji Jiang, Guanghong Wu, et al. “Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.” Kidney Int 81, no. 1 (January 2012): 94–99. https://doi.org/10.1038/ki.2011.297.
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    • Luo, Xiaoyan, Gentzon Hall, Songtao Li, Andrew Bird, Peter J. Lavin, Michelle P. Winn, Alex R. Kemper, Talmage T. Brown, and Dwight D. Koeberl. “Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector.” Mol Ther 19, no. 11 (November 2011): 1961–70. https://doi.org/10.1038/mt.2011.126.
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    • Eckel, Jason, Peter J. Lavin, Elizabeth A. Finch, Nirvan Mukerji, Jarrett Burch, Rasheed Gbadegesin, Guanghong Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria.” J Am Soc Nephrol 22, no. 3 (March 2011): 526–35. https://doi.org/10.1681/ASN.2010050522.
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    • Rogers, Terry B., Shibani Pati, Shirley Gaa, Dushon Riley, Aarif Y. Khakoo, Shalin Patel, Robert D. Wardlow, et al. “Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes.” J Mol Cell Cardiol 50, no. 2 (February 2011): 346–56. https://doi.org/10.1016/j.yjmcc.2010.09.001.
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    • Hall, Gentzon, Jeffery D. Hasday, and Terry B. Rogers. “Regulating the regulator: NF-kappaB signaling in heart.” J Mol Cell Cardiol 41, no. 4 (October 2006): 580–91. https://doi.org/10.1016/j.yjmcc.2006.07.006.
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    • Weiner, Carl P., Clifford Mason, Gentzon Hall, Usma Ahmad, Peter Swaan, and Irina A. Buhimschi. “Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig.” Am J Obstet Gynecol 195, no. 1 (July 2006): 275–87. https://doi.org/10.1016/j.ajog.2005.12.050.
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    • Khakoo, Aarif Y., Shibani Pati, Stasia A. Anderson, William Reid, Mohamed F. Elshal, Ilsa I. Rovira, Ahn T. Nguyen, et al. “Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.” J Exp Med 203, no. 5 (May 15, 2006): 1235–47. https://doi.org/10.1084/jem.20051921.
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    • Hall, Gentzon, Ishwar S. Singh, Lisa Hester, Jeffery D. Hasday, and Terry B. Rogers. “Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation.” Am J Physiol Heart Circ Physiol 289, no. 5 (November 2005): H2103–11. https://doi.org/10.1152/ajpheart.00393.2005.
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    • Wright, Gary, Ishwar S. Singh, Jeffery D. Hasday, Iain K. Farrance, Gentzon Hall, Allan S. Cross, and Terry B. Rogers. “Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression.” Am J Physiol Heart Circ Physiol 282, no. 3 (March 2002): H872–79. https://doi.org/10.1152/ajpheart.00256.2001.
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    • Buhimschi, I. A., G. Hall, L. P. Thompson, and C. P. Weiner. “Pregnancy and estradiol decrease GTPase activity in the guinea pig uterine artery.” Am J Physiol Heart Circ Physiol 281, no. 5 (November 2001): H2168–75. https://doi.org/10.1152/ajpheart.2001.281.5.H2168.
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