Gentzon Hall
Assistant Professor of Medicine
My research is focused on defining the molecular underpinnings of podocyte injury and dysfunction in nephrotic syndrome (NS) with a primary focus on focal segmental glomerulosclerosis (FSGS). FSGS is the most common primary glomerular disease that causes end-stage kidney disease in the US and is caused by injury or loss of glomerular visceral epithelial cells (i.e. podocytes). My scientific contributions in the field include the identification of a novel heterozygous missense mutation in Wilms’ Tumor 1 (WT1) that caused non-syndromic familial FSGS (1), the identification of a dominant negative effect of the LIM Homeobox Transcription Factor 1ß R246Q mutation on expression of WT1 (-KTS) isoforms that contributes to the renal-specific phenotype associated with Nail Patella-like Renal Disease (2), and the identification of impaired autophagy and ER stress pathway activation as the cause of podocyte dysfunction and apoptosis induced by the human FSGS-causing ANLN R431C mutation (3). The goal of my research program is to translate novel discoveries in renal genetics into rational therapies and diagnostic tools for patients with NS.
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2021
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2015
Contact Information
- Dept of Medicine, Box 31108 DUMC, Durham, NC 27710
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gentzon.hall@duke.edu
(919) 684-8111
- Background
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Education, Training, & Certifications
- Nephrology Fellowship, Medicine, Duke University School of Medicine 2011 - 2015
- Internal Medicine Residency, Medicine, Duke University School of Medicine 2007 - 2010
- MD./PhD., University of Maryland, Baltimore 2007
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Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2018 - 2020
- Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2015 - 2018
- Recognition
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In the News
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APR 4, 2018 Duke Med School Blog
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- Research
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Selected Grants
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External Relationships
- Chinook Therapeutics
- GoldFinch Bio
- Inside Edge Consulting
- Otsuka Pharmaceuticals
- Reata Pharmaceuticals, Inc.
- Third Bridge Consulting
- Travere Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Nystrom, Sarah E., Guojie Li, Somenath Datta, Karen L. Soldano, Daniel Silas, Astrid Weins, Gentzon Hall, David B. Thomas, and Opeyemi A. Olabisi. “JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.” Jci Insight 7, no. 11 (June 8, 2022). https://doi.org/10.1172/jci.insight.157432.Full Text Link to Item
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Hall, Gentzon, and Jennie Lin. “Outscoring Current Classification Systems for Nephrotic Syndrome.” Am J Kidney Dis 79, no. 6 (June 2022): 783–84. https://doi.org/10.1053/j.ajkd.2021.12.005.Full Text Link to Item
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Ren, Jiafa, Xiaohan Lu, Gentzon Hall, Jamie R. Privratsky, Matthew J. Robson, Randy D. Blakely, and Steven D. Crowley. “IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.” Am J Physiol Renal Physiol 322, no. 2 (February 1, 2022): F164–74. https://doi.org/10.1152/ajprenal.00353.2021.Full Text Link to Item
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Lane, Brandon M., Megan Chryst-Stangl, Guanghong Wu, Mohamed Shalaby, Sherif El Desoky, Claire C. Middleton, Kinsie Huggins, et al. “Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis.” Jci Insight 7, no. 2 (January 25, 2022). https://doi.org/10.1172/jci.insight.152102.Full Text Link to Item
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Ren, Jiafa, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, and Steven D. Crowley. “Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.” Jci Insight 6, no. 15 (August 9, 2021). https://doi.org/10.1172/jci.insight.148109.Full Text Link to Item
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Hall, Gentzon, and Christina M. Wyatt. “Mechanisms of Proteinuria in HIV.” Front Med (Lausanne) 8 (2021): 749061. https://doi.org/10.3389/fmed.2021.749061.Full Text Link to Item
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Hall, Gentzon, Liming Wang, and Robert F. Spurney. “TRPC Channels in Proteinuric Kidney Diseases.” Cells 9, no. 1 (December 23, 2019). https://doi.org/10.3390/cells9010044.Full Text Link to Item
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Hall, Gentzon, Brandon M. Lane, Kamal Khan, Igor Pediaditakis, Jianqiu Xiao, Guanghong Wu, Liming Wang, et al. “The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.” J Am Soc Nephrol 29, no. 8 (August 2018): 2110–22. https://doi.org/10.1681/ASN.2017121338.Full Text Link to Item
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Varner, Jennifer D., Megan Chryst-Stangl, Christopher Imokhuede Esezobor, Adaobi Solarin, Guanghong Wu, Brandon Lane, Gentzon Hall, et al. “Genetic Testing for Steroid-Resistant-Nephrotic Syndrome in an Outbred Population.” Front Pediatr 6 (2018): 307. https://doi.org/10.3389/fped.2018.00307.Full Text Link to Item
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Hall, Gentzon, and Robert F. Spurney. “Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.” Kidney Int 92, no. 2 (August 2017): 283–85. https://doi.org/10.1016/j.kint.2017.03.045.Full Text Link to Item
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Hall, Gentzon, Jonathan C. Routh, and Rasheed A. Gbadegesin. “Urinary Anomalies in 22q11.2 Deletion (DiGeorge syndrome): From Copy Number Variations to Single-Gene Determinants of Phenotype.” Am J Kidney Dis 70, no. 1 (July 2017): 8–10. https://doi.org/10.1053/j.ajkd.2017.03.017.Full Text Link to Item
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Hall, Gentzon, Brandon Lane, Megan Chryst-Ladd, Guanghong Wu, Jen-Jar Lin, XueJun Qin, Elizabeth R. Hauser, and Rasheed Gbadegesin. “Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation.” Sci Rep 7 (January 6, 2017): 39933. https://doi.org/10.1038/srep39933.Full Text Link to Item
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Elahi, Shan, Alison Homstad, Himani Vaidya, Jennifer Stout, Gentzon Hall, Guanghong Wu, Peter Conlon, et al. “Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.” Pediatr Nephrol 31, no. 2 (February 2016): 247–53. https://doi.org/10.1007/s00467-015-3203-6.Full Text Link to Item
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Phelan, Paul J., Gentzon Hall, Delbert Wigfall, John Foreman, Shashi Nagaraj, Andrew F. Malone, Michelle P. Winn, David N. Howell, and Rasheed Gbadegesin. “Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation.” Clin Kidney J 8, no. 5 (October 2015): 538–42. https://doi.org/10.1093/ckj/sfv063.Full Text Open Access Copy Link to Item
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Gbadegesin, Rasheed A., Adebowale Adeyemo, Nicholas J. A. Webb, Larry A. Greenbaum, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arundhati Kale, et al. “HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.” J Am Soc Nephrol 26, no. 7 (July 2015): 1701–10. https://doi.org/10.1681/ASN.2014030247.Full Text Link to Item
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Hall, Gentzon, and Rasheed A. Gbadegesin. “Translating genetic findings in hereditary nephrotic syndrome: the missing loops.” Am J Physiol Renal Physiol 309, no. 1 (July 1, 2015): F24–28. https://doi.org/10.1152/ajprenal.00683.2014.Full Text Link to Item
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Hall, Gentzon, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Yangfan Liu, Edwin C. Oh, Liming Wang, et al. “A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.” J Am Soc Nephrol 26, no. 4 (April 2015): 831–43. https://doi.org/10.1681/ASN.2013101053.Full Text Link to Item
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Gbadegesin, Rasheed A., Gentzon Hall, Adebowale Adeyemo, Nils Hanke, Irini Tossidou, James Burchette, Guanghong Wu, et al. “Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.” J Am Soc Nephrol 25, no. 9 (September 2014): 1991–2002. https://doi.org/10.1681/ASN.2013090976.Full Text Link to Item
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Hall, Gentzon, Janelle Rowell, Federica Farinelli, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Alison Homstad, et al. “Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.” Am J Physiol Renal Physiol 306, no. 12 (June 15, 2014): F1442–50. https://doi.org/10.1152/ajprenal.00212.2013.Full Text Link to Item
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Malone, A. F., P. J. Phelan, G. Hall, U. Cetincelik, A. Homstad, A. S. Alonso, R. Jiang, et al. “Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.” Kidney International 86, no. 6 (January 1, 2014): 1253–59. https://doi.org/10.1038/ki.2014.305.Full Text
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Eckel, J., P. J. Lavin, E. A. Finch, N. Mukerji, J. Burch, R. Gbadegesin, G. Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria (Journal of the American Society of Nephrology (2011) 22 (526-535)).” Journal of the American Society of Nephrology 24, no. 1 (December 28, 2013): 160. https://doi.org/10.1681/ASN.2012111069.Full Text
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Gbadegesin, Rasheed A., Patrick D. Brophy, Adebowale Adeyemo, Gentzon Hall, Indra R. Gupta, David Hains, Bartlomeij Bartkowiak, et al. “TNXB mutations can cause vesicoureteral reflux.” J Am Soc Nephrol 24, no. 8 (July 2013): 1313–22. https://doi.org/10.1681/ASN.2012121148.Full Text Link to Item
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Gbadegesin, Rasheed A., Peter J. Lavin, Gentzon Hall, Bartlomiej Bartkowiak, Alison Homstad, Ruiji Jiang, Guanghong Wu, et al. “Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.” Kidney Int 81, no. 1 (January 2012): 94–99. https://doi.org/10.1038/ki.2011.297.Full Text Link to Item
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Luo, Xiaoyan, Gentzon Hall, Songtao Li, Andrew Bird, Peter J. Lavin, Michelle P. Winn, Alex R. Kemper, Talmage T. Brown, and Dwight D. Koeberl. “Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector.” Mol Ther 19, no. 11 (November 2011): 1961–70. https://doi.org/10.1038/mt.2011.126.Full Text Link to Item
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Eckel, Jason, Peter J. Lavin, Elizabeth A. Finch, Nirvan Mukerji, Jarrett Burch, Rasheed Gbadegesin, Guanghong Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria.” J Am Soc Nephrol 22, no. 3 (March 2011): 526–35. https://doi.org/10.1681/ASN.2010050522.Full Text Link to Item
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Rogers, Terry B., Shibani Pati, Shirley Gaa, Dushon Riley, Aarif Y. Khakoo, Shalin Patel, Robert D. Wardlow, et al. “Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes.” J Mol Cell Cardiol 50, no. 2 (February 2011): 346–56. https://doi.org/10.1016/j.yjmcc.2010.09.001.Full Text Link to Item
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Hall, Gentzon, Jeffery D. Hasday, and Terry B. Rogers. “Regulating the regulator: NF-kappaB signaling in heart.” J Mol Cell Cardiol 41, no. 4 (October 2006): 580–91. https://doi.org/10.1016/j.yjmcc.2006.07.006.Full Text Link to Item
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Weiner, Carl P., Clifford Mason, Gentzon Hall, Usma Ahmad, Peter Swaan, and Irina A. Buhimschi. “Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig.” Am J Obstet Gynecol 195, no. 1 (July 2006): 275–87. https://doi.org/10.1016/j.ajog.2005.12.050.Full Text Link to Item
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Khakoo, Aarif Y., Shibani Pati, Stasia A. Anderson, William Reid, Mohamed F. Elshal, Ilsa I. Rovira, Ahn T. Nguyen, et al. “Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.” J Exp Med 203, no. 5 (May 15, 2006): 1235–47. https://doi.org/10.1084/jem.20051921.Full Text Link to Item
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Hall, Gentzon, Ishwar S. Singh, Lisa Hester, Jeffery D. Hasday, and Terry B. Rogers. “Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation.” Am J Physiol Heart Circ Physiol 289, no. 5 (November 2005): H2103–11. https://doi.org/10.1152/ajpheart.00393.2005.Full Text Link to Item
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Wright, Gary, Ishwar S. Singh, Jeffery D. Hasday, Iain K. Farrance, Gentzon Hall, Allan S. Cross, and Terry B. Rogers. “Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression.” Am J Physiol Heart Circ Physiol 282, no. 3 (March 2002): H872–79. https://doi.org/10.1152/ajpheart.00256.2001.Full Text Link to Item
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Buhimschi, I. A., G. Hall, L. P. Thompson, and C. P. Weiner. “Pregnancy and estradiol decrease GTPase activity in the guinea pig uterine artery.” Am J Physiol Heart Circ Physiol 281, no. 5 (November 2001): H2168–75. https://doi.org/10.1152/ajpheart.2001.281.5.H2168.Full Text Link to Item
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Book Sections
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Hall, G. “Genetic Causes of Chronic Kidney Disease.” In Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rector’s The Kidney, 105-119.e7, 2018. https://doi.org/10.1016/B978-0-323-52978-5.00007-0.Full Text
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