Scholars@Duke
Geoffrey Steven Ginsburg

Geoffrey Steven Ginsburg

Adjunct Professor in the Department of Medicine
Medicine, Cardiology
Duke Box 3382, Durham, NC 27710
101 Science Dr, Rm 2111, CIEMAS Bldg, Durham, NC 27708

Featured Works

Global implementation of genomic medicine: We are not alone.

Journal article Sci Transl Med · June 3, 2015 Featured Publication Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual efforts might benefit fr ... Full text Link to item Cite

Aligning incentives to fulfil the promise of personalised medicine.

Journal article Lancet · May 23, 2015 Featured Publication Full text Link to item Cite

Comparing reference-based RNA-Seq mapping methods for non-human primate data.

Journal article BMC Genomics · July 7, 2014 Featured Publication BACKGROUND: The application of next-generation sequencing technology to gene expression quantification analysis, namely, RNA-Sequencing, has transformed the way in which gene expression studies are conducted and analyzed. These advances are of particular i ... Full text Link to item Cite

Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.

Journal article Am J Respir Cell Mol Biol · May 2014 Featured Publication Pneumococcal pneumonia is a leading cause of bacterial infection and death worldwide. Current diagnostic tests for detecting Streptococcus pneumoniae can be unreliable and can mislead clinical decision-making and treatment. To address this concern, we deve ... Full text Link to item Cite

Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip.

Journal article Anal Bioanal Chem · May 2014 Featured Publication Developing techniques for multiplex detection of disease biomarkers is important for clinical diagnosis. In this work, we have demonstrated for the first time the feasibility of multiplex detection of genetic disease biomarkers using the surface-enhanced R ... Full text Link to item Cite

Medical genomics: Gather and use genetic data in health care.

Journal article Nature · April 24, 2014 Featured Publication Full text Link to item Cite

An integrated transcriptome and expressed variant analysis of sepsis survival and death.

Journal article Genome Med · 2014 Featured Publication BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical ch ... Full text Open Access Link to item Cite

Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.

Journal article J Am Coll Cardiol · October 1, 2013 Featured Publication OBJECTIVES: The aim of this study was to develop ribonucleic acid (RNA) profiles that could serve as novel biomarkers for the response to aspirin. BACKGROUND: Aspirin reduces death and myocardial infarction (MI), suggesting that aspirin interacts with biol ... Full text Link to item Cite

A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.

Journal article Sci Transl Med · September 18, 2013 Featured Publication Improved ways to diagnose acute respiratory viral infections could decrease inappropriate antibacterial use and serve as a vital triage mechanism in the event of a potential viral pandemic. Measurement of the host response to infection is an alternative to ... Full text Link to item Cite

An integrated clinico-metabolomic model improves prediction of death in sepsis.

Journal article Sci Transl Med · July 24, 2013 Featured Publication Sepsis is a common cause of death, but outcomes in individual patients are difficult to predict. Elucidating the molecular processes that differ between sepsis patients who survive and those who die may permit more appropriate treatments to be deployed. We ... Full text Link to item Cite

Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics.

Journal article Anal Chim Acta · July 5, 2013 Featured Publication In this paper, we describe a surface-enhanced Raman scattering (SERS)-based detection approach, referred to as "molecular sentinel" (MS) plasmonic nanoprobes, to detect an RNA target related to viral infection. The MS method is essentially a label-free tec ... Full text Link to item Cite

Realizing the opportunities of genomics in health care.

Journal article JAMA · April 10, 2013 Featured Publication Full text Link to item Cite

Transforming epidemiology for 21st century medicine and public health.

Journal article Cancer Epidemiol Biomarkers Prev · April 2013 Featured Publication In 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agen ... Full text Link to item Cite

Patient clustering with uncoded text in electronic medical records.

Journal article AMIA Annu Symp Proc · 2013 Featured Publication We propose a mixture model for text data designed to capture underlying structure in the history of present illness section of electronic medical records data. Additionally, we propose a method to induce bias that leads to more homogeneous sets of diagnose ... Link to item Cite

Development and validation of a primary care-based family health history and decision support program (MeTree).

Journal article N C Med J · 2013 Featured Publication INTRODUCTION: Family health history is a strong predictor of disease risk. To reduce the morbidity and mortality of many chronic diseases, risk-stratified evidence-based guidelines strongly encourage the collection and synthesis of family health history to ... Link to item Cite

Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond.

Journal article J Clin Oncol · December 1, 2012 Featured Publication Despite stunning advances in our understanding of the genetics and the molecular basis for cancer, many patients with cancer are not yet receiving therapy tailored specifically to their tumor biology. The translation of these advances into clinical practic ... Full text Link to item Cite

The oral microbiome in health and disease and the potential impact on personalized dental medicine.

Journal article Oral Dis · March 2012 Featured Publication Every human body contains a personalized microbiome that is essential to maintaining health but capable of eliciting disease. The oral microbiome is particularly imperative to health because it can cause both oral and systemic disease. The oral microbiome ... Full text Link to item Cite

Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system.

Journal article BMC Health Serv Res · October 11, 2011 Featured Publication BACKGROUND: The CDC's Family History Public Health Initiative encourages adoption and increase awareness of family health history. To meet these goals and develop a personalized medicine implementation science research agenda, the Genomedical Connection is ... Full text Open Access Link to item Cite

Academic medical centers: ripe for rapid-learning personalized health care.

Journal article Sci Transl Med · September 21, 2011 Featured Publication In an attempt to reduce the lengthy process of translating scientific findings into clinical practice, the United States and several European governments are making substantial investments in health information technology, comparative effectiveness researc ... Full text Link to item Cite

Predicting Viral Infection From High-Dimensional Biomarker Trajectories.

Journal article J Am Stat Assoc · January 1, 2011 Featured Publication There is often interest in predicting an individual's latent health status based on high-dimensional biomarkers that vary over time. Motivated by time-course gene expression array data that we have collected in two influenza challenge studies performed wit ... Full text Link to item Cite

Personalized medicine: progress and promise.

Journal article Annu Rev Genomics Hum Genet · 2011 Featured Publication Personalized medicine is a broad and rapidly advancing field of health care that is informed by each person's unique clinical, genetic, genomic, and environmental information. Personalized medicine depends on multidisciplinary health care teams and integra ... Full text Link to item Cite

Opening up to precompetitive collaboration.

Journal article Sci Transl Med · October 6, 2010 Featured Publication In order to enhance biomedical research and development efficiency and innovation, nontraditional research collaborations have emerged that feature the sharing of information, resources, and capabilities. Although many of these so-called precompetitive col ... Full text Link to item Cite

Regression of atherosclerosis with therapeutic antibodies pipe cleaner or pipe dream?

Journal article J Am Coll Cardiol · December 11, 2007 Featured Publication Full text Link to item Cite

Genetic profiling and tailored therapy in asthma: are we there yet?

Journal article Curr Opin Mol Ther · December 2007 Featured Publication Asthma is characterized by reversible bronchial hyper-responsiveness and airway inflammation, and encompasses a wide variety of patients with different clinical phenotypes that display variable responses to therapy. The definition of genomic variation pres ... Link to item Cite

Taking cardiovascular genetic association studies to the next level.

Journal article J Am Coll Cardiol · September 4, 2007 Featured Publication Genetic information is beginning to have a direct impact on patient care and it is important that cardiologists appreciate the value and approaches to associating genetic variation and health outcomes. Genetic associations should be based on compelling gen ... Full text Link to item Cite

Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate.

Journal article J Rheumatol · September 2007 Featured Publication OBJECTIVE: To evaluate peripheral blood expression of genes regulated by nuclear factor-kappaB (NF-kappaB), a key mediator of tumor necrosis factor-alpha (TNF-alpha) signaling, in patients with rheumatoid arthritis (RA) before and during treatment with ant ... Link to item Cite

Gene expression signatures that predict radiation exposure in mice and humans.

Journal article PLoS Med · April 2007 Featured Publication BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure to ionizing radiation. METHOD ... Full text Open Access Link to item Cite

An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.

Other J Clin Oncol · February 10, 2007 Featured Publication PURPOSE: The purpose of this study was to develop an integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. We have used gene expression profiles to identify patients likely to be resistant to primary pl ... Full text Link to item Cite

Genomic signatures to guide the use of chemotherapeutics.

Other Nat Med · November 2006 Featured Publication Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of ... Full text Link to item Cite

Microarrays coming of age in cardiovascular medicine: standards, predictions, and biology.

Journal article J Am Coll Cardiol · October 17, 2006 Featured Publication Full text Link to item Cite

Public health. Genomics and medicine at a crossroads in Chernobyl.

Journal article Science · October 6, 2006 Featured Publication Full text Link to item Cite

A framework to evaluate the economic impact of pharmacogenomics.

Journal article Pharmacogenomics · September 2006 Featured Publication INTRODUCTION: Pharmacogenomics and personalized medicine promise to improve healthcare by increasing drug efficacy and minimizing side effects. There may also be substantial savings realized by eliminating costs associated with failed treatment. This paper ... Full text Link to item Cite

A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.

Journal article N Engl J Med · August 10, 2006 Featured Publication BACKGROUND: Clinical trials have indicated a benefit of adjuvant chemotherapy for patients with stage IB, II, or IIIA--but not stage IA--non-small-cell lung cancer (NSCLC). This classification scheme is probably an imprecise predictor of the prognosis of a ... Full text Link to item Cite

Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications.

Journal article J Am Coll Cardiol · July 18, 2006 Featured Publication Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies ... Full text Link to item Cite

Prescribing BiDil: is it black and white?

Journal article J Am Coll Cardiol · July 4, 2006 Featured Publication The approval of BiDil as an adjunct treatment in self-identified blacks with heart failure raises questions regarding the underlying etiology of drug response in this target population and the ability to accurately identify patients who are most likely to ... Full text Link to item Cite

Genomic analyses: a neonatology perspective.

Journal article J Pediatr · June 2006 Featured Publication Full text Link to item Cite

Embracing the complexity of genomic data for personalized medicine.

Journal article Genome Res · May 2006 Featured Publication Numerous recent studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in cancer and other complex diseases. Such studies herald the future of genomic medicine and the opportunity for pers ... Full text Link to item Cite

Translating genomic biomarkers into clinically useful diagnostics.

Journal article Expert Rev Mol Diagn · March 2006 Featured Publication The landmark sequencing of the human genome has ushered in a new field of large-scale research. Advances in understanding the molecular basis of disease have opened up new opportunities to develop genomics-based tools to diagnose, predict disease onset or ... Full text Link to item Cite

Implications of pharmacogenomics for drug development and clinical practice.

Journal article Arch Intern Med · November 14, 2005 Featured Publication Pharmacogenomics is likely to be among the first clinical applications of the Human Genome Project and is certain to have an enormous impact on the clinical practice of medicine. Herein, we discuss the potential implications of pharmacogenomics on the drug ... Full text Link to item Cite

Prospects for personalized cardiovascular medicine: the impact of genomics.

Journal article J Am Coll Cardiol · November 1, 2005 Featured Publication Sequencing of the human genome has ushered in prospects for individualizing cardiovascular health care. There is growing evidence that the practice of cardiovascular medicine might soon have a new toolbox to predict and treat disease more effectively. The ... Full text Link to item Cite

Genomic medicine: genetic variation and its impact on the future of health care.

Journal article Philos Trans R Soc Lond B Biol Sci · August 29, 2005 Featured Publication Advances in genome technology and other fruits of the Human Genome Project are playing a growing role in the delivery of health care. With the development of new technologies and opportunities for large-scale analysis of the genome, transcriptome, proteome ... Full text Link to item Cite

Genomic medicine: bringing biomarkers to clinical medicine.

Journal article Curr Opin Chem Biol · August 2005 Featured Publication An important by-product of sequencing the human genome has been the development of a novel 'toolbox' for biomarker discovery and development. Genomic medicine is an emerging discipline in the genome sciences that integrates these tools to interrogate genom ... Full text Link to item Cite

The Personalized Medicine Coalition: goals and strategies.

Journal article Am J Pharmacogenomics · 2005 Featured Publication The concept of personalized medicine--that medical care can be tailored to the genomic and molecular profile of the individual--has repercussions that extend far beyond the technology that makes it possible. The adoption of personalized medicine will requi ... Full text Link to item Cite

Targeted therapies for cancer 2004.

Journal article Am J Clin Pathol · October 2004 Featured Publication The regulatory agency approvals in the United States and Europe of imatinib mesylate (Gleevec) for patients with bcr/abl-positive chronic myelogenous leukemia, cetuximab (Erbitux) for patients with epidermal growth factor receptor overexpressing metastatic ... Full text Link to item Cite

Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care.

Journal article Expert Rev Mol Diagn · November 2002 Featured Publication The Introduction of targeted therapeutics into clinical practice has created major opportunities for further development of the molecular diagnostics industry. Emerging genomic and proteomic technologies and information are now resulting in the molecular s ... Full text Link to item Cite

The path to personalized medicine.

Journal article Curr Opin Chem Biol · August 2002 Featured Publication Advances in personalized medicine, or the use of an individual's molecular profile to direct the practice of medicine, have been greatly enabled through human genome research. This research is leading to the identification of a range of molecular markers f ... Full text Link to item Cite

Personalized medicine: revolutionizing drug discovery and patient care.

Journal article Trends Biotechnol · December 2001 Featured Publication Advances in human genome research are opening the door to a new paradigm for practising medicine that promises to transform healthcare. Personalized medicine, the use of marker-assisted diagnosis and targeted therapies derived from an individual's molecula ... Full text Link to item Cite