Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Stanford University 1994
• 

  Previous Appointments & Affiliations

  • Instructor in the Department of Neurosurgery, Neurosurgery, Neurosurgery 2022
  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2006 - 2013
  • Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 2009 - 2013
  • Associate Professor of Surgery, Neurosurgery, Neurosurgery 2013
  • Associate Professor of Surgery, Neurosurgery, Neurosurgery 2009 - 2012
  • Assistant Professor in Surgery, Neurosurgery, Neurosurgery 2007 - 2009
  • Assistant Professor in Pediatrics, Pediatrics, Clinical Science Departments 2007 - 2009
  • Instructor, Temporary in the Department of Surgery, Neurosurgery, Neurosurgery 2006 - 2007
• Research
• 

  Selected Grants

  • Exploratory genomic investigations of mesial temporal lobe epilepsy awarded by National Institutes of Health 2012 - 2015
  • Modulation of the blood-tumor barrier through targeted suppression of claudin 5 awarded by National Institutes of Health 2011 - 2013
  • Stem Cells, Progenitors, and the Origin of Medulloblastoma awarded by National Institutes of Health 2009 - 2010
  • Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
• 

  External Relationships

  • Aesculap
  • NeuroOne
  • integra life sciences
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Laskowitz, D., and G. Grant. Translational research in traumatic brain injury, 2016.

  • Academic Articles

    • Bouchard, Heather C., Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, et al. “Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury.” Hum Brain Mapp 43, no. 8 (June 1, 2022): 2653–67. https://doi.org/10.1002/hbm.25811.
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    • Zhang, Michael, Samuel W. Wong, Jason N. Wright, Matthias W. Wagner, Sebastian Toescu, Michelle Han, Lydia T. Tam, et al. “MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.” Radiology, April 19, 2022, 212137. https://doi.org/10.1148/radiol.212137.
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    • Akbari, S Hassan A., Alexander T. Yahanda, Laurie L. Ackerman, P David Adelson, Raheel Ahmed, Gregory W. Albert, Philipp R. Aldana, et al. “Complications and outcomes of posterior fossa decompression with duraplasty versus without duraplasty for pediatric patients with Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.” J Neurosurg Pediatr, April 15, 2022, 1–13. https://doi.org/10.3171/2022.2.PEDS21446.
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    • Sadler, Brooke, Alex Skidmore, Jordan Gewirtz, Richard C. E. Anderson, Gabe Haller, Laurie L. Ackerman, P David Adelson, et al. “Extradural decompression versus duraplasty in Chiari malformation type I with syrinx: outcomes on scoliosis from the Park-Reeves Syringomyelia Research Consortium.” J Neurosurg Pediatr, June 18, 2021, 1–9. https://doi.org/10.3171/2020.12.PEDS20552.
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    • Smith, Alicia K., Andrew Ratanatharathorn, Adam X. Maihofer, Robert K. Naviaux, Allison E. Aiello, Ananda B. Amstadter, Allison E. Ashley-Koch, et al. “Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.” Nat Commun 11, no. 1 (November 24, 2020): 5965. https://doi.org/10.1038/s41467-020-19615-x.
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    • Fisher, Lauren B., Jessica Bomyea, Garrett Thomas, Joey C. Cheung, Feng He, Sonia Jain, Laura A. Flashman, et al. “Contributions of posttraumatic stress disorder (PTSD) and mild TBI (mTBI) history to suicidality in the INTRuST consortium.” Brain Inj 34, no. 10 (August 23, 2020): 1339–49. https://doi.org/10.1080/02699052.2020.1807054.
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    • Azad, Tej D., Austin Y. Feng, Swapnil Mehta, Alex B. Bak, Eli Johnson, Vaishali Mittal, Rogelio Esparza, Anand Veeravagu, Casey H. Halpern, and Gerald A. Grant. “Randomized Controlled Trials in Functional Neurosurgery-Association of Device Approval Status and Trial Quality.” Neuromodulation 23, no. 4 (June 2020): 496–501. https://doi.org/10.1111/ner.13083.
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    • Vaca, Silvia D., Austin Y. Feng, Seul Ku, Michael C. Jin, Bina W. Kakusa, Allen L. Ho, Michael Zhang, Anthony Fuller, Michael M. Haglund, and Gerald Grant. “Boda Bodas and Road Traffic Injuries in Uganda: An Overview of Traffic Safety Trends from 2009 to 2017.” Int J Environ Res Public Health 17, no. 6 (March 22, 2020). https://doi.org/10.3390/ijerph17062110.
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    • Logue, Mark W., Mark W. Miller, Erika J. Wolf, Bertrand Russ Huber, Filomene G. Morrison, Zhenwei Zhou, Yuanchao Zheng, et al. “An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.” Clin Epigenetics 12, no. 1 (March 14, 2020): 46. https://doi.org/10.1186/s13148-020-0820-0.
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    • Bomyea, Jessica, Alan N. Simmons, Martha E. Shenton, Michael J. Coleman, Sylvain Bouix, Yogesh Rathi, Ofer Pasternak, et al. “Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium.” J Psychiatr Res 121 (February 2020): 108–17. https://doi.org/10.1016/j.jpsychires.2019.11.012.
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    • Flores, C., T. Wildes, B DiVita Dean, G. Moore, J. Drake, R. Abraham, J. Gil, et al. “Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy.” Sci Adv 5, no. 11 (November 2019): eaav9879. https://doi.org/10.1126/sciadv.aav9879.
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    • SoRelle, Elliott Daniel, Derek William Yecies, Orly Liba, Frederick Christian Bennett, Claus Moritz Graef, Rebecca Dutta, Siddhartha Mitra, et al. “Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation.” Acs Nano 13, no. 7 (July 23, 2019): 7985–95. https://doi.org/10.1021/acsnano.9b02656.
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    • Pan, James, Jennifer L. Quon, Eli Johnson, Bryan Lanzman, Anjeza Chukus, Allen L. Ho, Michael S. B. Edwards, Gerald A. Grant, and Kristen W. Yeom. “Rapid-sequence brain magnetic resonance imaging for Chiari I abnormality.” J Neurosurg Pediatr 22, no. 2 (August 2018): 158–64. https://doi.org/10.3171/2018.2.PEDS17523.
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    • Lepage, Christian, Amicie de Pierrefeu, Inga K. Koerte, Michael J. Coleman, Ofer Pasternak, Gerald Grant, Christine E. Marx, et al. “White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study.” Brain Imaging Behav 12, no. 3 (June 2018): 870–81. https://doi.org/10.1007/s11682-017-9744-5.
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    • Winawer, Melodie R., Nicole G. Griffin, Jorge Samanamud, Evan H. Baugh, Dinesh Rathakrishnan, Senthilmurugan Ramalingam, David Zagzag, et al. “Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy.” Ann Neurol 83, no. 6 (June 2018): 1133–46. https://doi.org/10.1002/ana.25243.
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    • Xu, Linda W., Silvia D. Vaca, Juliet Nalwanga, Christine Muhumuza, Daniel Vail, Benjamin J. Lerman, Joel Kiryabwire, et al. “Life After the Neurosurgical Ward in Sub-Saharan Africa: Neurosurgical Treatment and Outpatient Outcomes in Uganda.” World Neurosurg 113 (May 2018): e153–60. https://doi.org/10.1016/j.wneu.2018.01.204.
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    • Vanags, Jonas, Monisha Sachdev, Gerald Grant, and Mohamad A. Mikati. “Visual hallucinations: A novel complication after hemispherectomy.” Epilepsy Behav Case Rep 9 (2018): 51–53. https://doi.org/10.1016/j.ebcr.2017.09.005.
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    • Griffin, Nicole G., Kenneth D. Cronin, Nicole M. Walley, Christine M. Hulette, Gerald A. Grant, Mohamad A. Mikati, Heather G. LaBreche, et al. “Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly.” Cold Spring Harb Mol Case Stud 3, no. 5 (September 2017). https://doi.org/10.1101/mcs.a001735.
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    • Kuo, Benjamin J., Silvia D. Vaca, Joao Ricardo Nickenig Vissoci, Catherine A. Staton, Linda Xu, Michael Muhumuza, Hussein Ssenyonjo, et al. “A prospective neurosurgical registry evaluating the clinical care of traumatic brain injury patients presenting to Mulago National Referral Hospital in Uganda.” Plos One 12, no. 10 (2017): e0182285. https://doi.org/10.1371/journal.pone.0182285.
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    • Chou, N. D., S. Serafini, G. A. Grant, M. Clyde, J. Komisarow, and C. R. Muh. “127 Multimodality Word-Finding Distinctions in Pediatric Cortical Stimulation Mapping.” Neurosurgery 63, no. CN_suppl_1 (August 1, 2016): 152. https://doi.org/10.1227/01.neu.0000489697.88290.88.
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    • Smith, Edward C., Kathryn Idol Xixis, Gerald A. Grant, and Stuart A. Grant. “Assessment of obstetric brachial plexus injury with preoperative ultrasound.” Muscle Nerve 53, no. 6 (June 2016): 946–50. https://doi.org/10.1002/mus.24975.
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    • Thompson, Eric M., Thomas Hielscher, Eric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E. McLendon, et al. “Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.” Lancet Oncol 17, no. 4 (April 2016): 484–95. https://doi.org/10.1016/S1470-2045(15)00581-1.
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    • Halvorson, Kyle G., Ryan T. Kellogg, Krista N. Keachie, Gerald A. Grant, Carrie R. Muh, and Ben Waldau. “Morphometric Analysis of Predictors of Cervical Syrinx Formation in the Setting of Chiari I Malformation.” Pediatr Neurosurg 51, no. 3 (2016): 137–41. https://doi.org/10.1159/000442991.
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    • Sun, Jessica M., Gerald A. Grant, Colleen McLaughlin, June Allison, Anne Fitzgerald, Barbara Waters-Pick, and Joanne Kurtzberg. “Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus.” Pediatr Res 78, no. 6 (December 2015): 712–16. https://doi.org/10.1038/pr.2015.161.
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    • Autmizguine, Julie, Cassie Moran, Daniel Gonzalez, Edmund V. Capparelli, P Brian Smith, Gerald A. Grant, Daniel K. Benjamin, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections.” Pediatr Infect Dis J 33, no. 10 (October 2014): e270–72. https://doi.org/10.1097/INF.0000000000000385.
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    • Markunas, Christina A., Eric Lock, Karen Soldano, Heidi Cope, Chien-Kuang C. Ding, David S. Enterline, Gerald Grant, Herbert Fuchs, Allison E. Ashley-Koch, and Simon G. Gregory. “Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics.” Bmc Med Genomics 7 (June 25, 2014): 39. https://doi.org/10.1186/1755-8794-7-39.
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    • Yuan, Hsiangkuo, Christy M. Wilson, Jun Xia, Sarah L. Doyle, Shuqin Li, Andrew M. Fales, Yang Liu, et al. “Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor.” Nanoscale 6, no. 8 (April 21, 2014): 4078–82. https://doi.org/10.1039/c3nr06770j.
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    • Kool, Marcel, David T. W. Jones, Natalie Jäger, Paul A. Northcott, Trevor J. Pugh, Volker Hovestadt, Rosario M. Piro, et al. “Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.” Cancer Cell 25, no. 3 (March 17, 2014): 393–405. https://doi.org/10.1016/j.ccr.2014.02.004.
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    • López, G. Y., G. A. Grant, H. E. Fuchs, L. G. Leithe, S. Gururangan, D. D. Bigner, H. Yan, R. E. McLendon, and Y. He. “Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.” Neuropathol Appl Neurobiol 40, no. 2 (February 2014): 217–20. https://doi.org/10.1111/nan.12060.
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    • Markunas, Christina A., David S. Enterline, Kaitlyn Dunlap, Karen Soldano, Heidi Cope, Jeffrey Stajich, Gerald Grant, Herbert Fuchs, Simon G. Gregory, and Allison E. Ashley-Koch. “Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation.” Ann Hum Genet 78, no. 1 (January 2014): 1–12. https://doi.org/10.1111/ahg.12041.
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    • Yuan, H., C. M. Wilson, S. Li, A. M. Fales, Y. Liu, G. Grant, and T. Vo-Dinh. “Optically enhanced blood-brain-barrier crossing of plasmonic-active nanoparticles in preclinical brain tumor animal models.” Progress in Biomedical Optics and Imaging  Proceedings of Spie 8935 (January 1, 2014). https://doi.org/10.1117/12.2040960.
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    • Serafini, Sandra, Jordan M. Komisarow, William Gallentine, Mohamad A. Mikati, Melanie J. Bonner, Peter G. Kranz, Michael M. Haglund, and Gerald Grant. “Reorganization and stability for motor and language areas using cortical stimulation: case example and review of the literature.” Brain Sci 3, no. 4 (November 26, 2013): 1597–1614. https://doi.org/10.3390/brainsci3041597.
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    • Seekell, Kevin, Spencer Lewis, Christy Wilson, Shuqin Li, Gerald Grant, and Adam Wax. “Feasibility study of brain tumor delineation using immunolabeled gold nanorods.” Biomed Opt Express 4, no. 11 (2013): 2284–95. https://doi.org/10.1364/BOE.4.002284.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 7. Neuroimaging.” Pediatric Critical Care Medicine 13 (January 2012): S33–35. https://doi.org/10.1097/pcc.0b013e31823f65e2.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 15. Analgesics, sedatives, and neuromuscular blockade.” Pediatric Critical Care Medicine 13 (January 2012): S64–67. https://doi.org/10.1097/pcc.0b013e31823f67fc.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 3. Indications for intracranial pressure monitoring.” Pediatric Critical Care Medicine 13 (January 2012): S11–17. https://doi.org/10.1097/pcc.0b013e31823f440c.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 6. Advanced neuromonitoring.” Pediatric Critical Care Medicine 13 (January 2012): S30–32. https://doi.org/10.1097/pcc.0b013e31823f659a.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 2. Methods.” Pediatric Critical Care Medicine 13 (January 2012): S7–10. https://doi.org/10.1097/pcc.0b013e31823f43df.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 14. Corticosteroids.” Pediatric Critical Care Medicine 13 (January 2012): S61–63. https://doi.org/10.1097/pcc.0b013e31823f67e3.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 13. Hyperventilation.” Pediatric Critical Care Medicine 13 (January 2012): S58–60. https://doi.org/10.1097/pcc.0b013e31823f67d0.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 16. Glucose and nutrition.” Pediatric Critical Care Medicine 13 (January 2012): S68–71. https://doi.org/10.1097/pcc.0b013e31823f681d.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 4. Threshold for treatment of intracranial hypertension.” Pediatric Critical Care Medicine 13 (January 2012): S18–23. https://doi.org/10.1097/pcc.0b013e31823f4424.
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    • Kochanek, Patrick M., P David Adelson, Stephen Ashwal, Michael J. Bell, Susan Bratton, Susan Carson, Randall M. Chesnut, et al. “Chapter 5. Cerebral perfusion pressure thresholds.” Pediatric Critical Care Medicine 13 (January 2012): S24–29. https://doi.org/10.1097/pcc.0b013e31823f4450.
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    • Grant, Gerald A. “Low Plasma D-Dimer Concentration Predicts the Absence of Traumatic Brain Injury in Children EDITORIAL COMMENT.” Journal of Trauma Injury Infection and Critical Care 68, no. 5 (May 2010): 1077–1077.
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  • Book Sections

    • Iffland, P. H., G. A. Grant, and D. Janigro. “Mechanisms of cerebral edema leading to early seizures after traumatic brain injury.” In Vascular Mechanisms in CNS Trauma, 29–45, 2014. https://doi.org/10.1007/978-1-4614-8690-9_2.
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  • Conference Papers

    • Grant, Gerald A., Christy Wilson, Matthew Campbell, Peter Humphries, Shuqin Li, Jianjun Li, Allan Johnson, Darell Bigner, and Mark Dewhirst. “REVERSIBLE OPENING OF THE BBB BY TARGETED SUPPRESSION OF CLAUDIN 5 TO ENHANCE DRUG DELIVERY TO BRAIN TUMORS.” In Neuro Oncology, 12:98–98. OXFORD UNIV PRESS INC, 2010.
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    • Phillips, S., S. W. Glickman, L. J. Stanley, R. J. Preston, G. A. Grant, D. T. Laskowitz, and C. B. Cairns. “270: C-reactive Protein as a Serum Biomarker in the Evaluation of Patients With Minor Head Injury and Normal Mental Status in the Emergency Department.” In Annals of Emergency Medicine, 52:S124–S124. Elsevier BV, 2008. https://doi.org/10.1016/j.annemergmed.2008.06.289.
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