Scholars@Duke
Gerald Arthur Grant

Gerald Arthur Grant

Allan H. Friedman Distinguished Professor of Neurosurgery
Neurosurgery
gerald.grant@duke.edu
Duke Box 3271, Durham, NC 27710
1554A Duke South, Box 3271, Durham, NC 27710

Scholarly Works - Conferences

KS01.6.A INTRATUMORAL IL-12/ANTI-PD-1 ONCOLYTIC HSV1 (MVR-C5252) IS SAFE AND IMMUNOACTIVE IN RECURRENT HIGH-GRADE GLIOMA: PRELIMINARY PHASE 1 RESULTS FROM A MULTICENTER MULTISTAGE CLINICAL TRIAL

Conference Neuro-Oncology · October 3, 2025 AbstractBACKGROUNDOncolytic viruses represent a promising immunotherapeutic strategy by combining direct tumor lysis with local immune ... Full text Cite

Abstract CT056: A phase 1 study of intratumoral HSV1 co-expressing IL-12 and PD1 blocking antibody (MVR-C5252) in recurrent high-grade glioma

Conference Cancer Research · April 25, 2025 AbstractBackground:Recurrent glioblastomas (GBM) and other high-grade gliomas (HGG) have poor outcomes. Oncolytic viruses (OVs) offer ... Full text Cite

1156 Autonomy Development in Pediatric Neurosurgery: Implications for Resident Training

Conference Neurosurgery · April 2025 INTRODUCTION:Pediatric neurosurgery presents distinct challenges in training and evaluating competency of neurosurgical residents due to the uniquely vulnerable population ... Full text Cite

CNSC-58. BIOPROCESSING OF VIABLE SURGICAL PEDIATRIC BRAIN TUMOR SPECIMENS FOR GENOME-GUIDED PERSONALIZED DRUG TESTING

Conference Neuro-Oncology · November 11, 2024 AbstractNovel treatment approaches are urgently needed for pediatric central nervous system (CNS) tumors as they are the leading cause of cancer-related deaths in children. A lack of research materials imped ... Full text Cite

P17.03.A MAGIC-G1: A PHASE 1 DOSE-ESCALATION TRIAL OF WEEKLY INTRATUMORAL ADMINISTRATION OF THE SOLUBILISED FORMULATION OF PANOBINOSTAT (MTX110) IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM)

Conference Neuro-Oncology · September 8, 2023 AbstractBACKGROUNDOne of the biggest challenges in treating rGBM is achieving high local drug concentration. Convection enhanced deliv ... Full text Cite

BIOL-20. BIOPROCESSING OF SURGICAL PEDIATRIC BRAIN TUMOR SPECIMENS FOR GENOME-GUIDED PERSONALIZED DRUG TESTING

Conference Neuro-Oncology · June 12, 2023 AbstractNovel treatment approaches are urgently needed for pediatric central nervous system (CNS) tumors as they are the leading cause of cancer-related deaths in children. A lack of research materials imped ... Full text Cite

Laboratory And On-field Testing Of A Commercially Available Padded Helmet Cover

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · September 2022 Link to item Cite

Incorporating patient-centered quality-of-life measures for outcome assessment after Chiari malformation type I decompression in a pediatric population: a pilot study.

Conference J Neurosurg Pediatr · February 1, 2022 OBJECTIVE: Optimal management of pediatric Chiari malformation type I (CM-I) is much debated, chiefly due to the lack of validated tools for outcome assessment, with very few tools incorporating patient-centered measures of health-related quality of life ( ... Full text Link to item Cite

Optimization of a Thermal Flow Meter for Failure Management of the Shunt in Pediatric Hydrocephalus Patients.

Conference Annu Int Conf IEEE Eng Med Biol Soc · November 2021 Hydrocephalus patients suffer from an abnormal buildup of cerebrospinal fluid (CSF) in their ventricles, and there is currently no known way to cure hydrocephalus. The most prevalent treatment for managing hydrocephalus is to implant a ventriculoperitoneal ... Full text Link to item Cite

OMIC-11. SINGLE CELL RNA SEQUENCING FROM THE CSF OF SUBJECTS WITH H3K27M+ DIPG/DMG TREATED WITH GD2 CAR T-CELLULAR THERAPY

Conference Neuro-Oncology · June 1, 2021 AbstractIntroductionWe are conducting a Phase I clinical trial utilizing chimeric antigen receptor (CAR) T-cells targeting GD2 (NCT041 ... Full text Cite

EPCT-14. GD2 CAR T-CELLS MEDIATE CLINICAL ACTIVITY AND MANAGEABLE TOXICITY IN CHILDREN AND YOUNG ADULTS WITH H3K27M-MUTATED DIPG AND SPINAL CORD DMG

Conference Neuro-Oncology · June 1, 2021 AbstractBackgroundWe previously discovered high expression of the disialoganglioside GD2 on H3K27M+ gliomas and demonstrated preclinic ... Full text Cite

BIOL-05. MAPK PATHWAY INHIBITION SENSITIZES TO IMMUNOTHERAPY IN BRAF-MUTANT GLIOMAS

Conference Neuro-Oncology · June 1, 2021 AbstractBackgroundBRAF alterations frequently occur in pediatric low-grade gliomas. Previously, we showed that dabrafenib and trametin ... Full text Cite

Artificial intelligence for automatic cerebral ventricle segmentation and volume calculation: a clinical tool for the evaluation of pediatric hydrocephalus.

Conference J Neurosurg Pediatr · February 1, 2021 OBJECTIVE: Imaging evaluation of the cerebral ventricles is important for clinical decision-making in pediatric hydrocephalus. Although quantitative measurements of ventricular size, over time, can facilitate objective comparison, automated tools for calcu ... Full text Link to item Cite

Influence of Instrumented Mouthguard Pre-trigger Time and Post-Trigger Time in Evaluating Brain Strain and Strain Rate in American Football Head Impacts

Conference Conference Proceedings International Research Council on the Biomechanics of Injury Ircobi · January 1, 2021 Cite

Statistical Interpretation of Predictive Factors of Head Impact Kinematics in Traumatic Brain Injury

Conference Conference Proceedings International Research Council on the Biomechanics of Injury Ircobi · January 1, 2021 Cite

Statistical Analysis of 18 Brain Injury Criteria in Evaluating Brain Strain on Different Types of Head Impact

Conference Conference Proceedings International Research Council on the Biomechanics of Injury Ircobi · January 1, 2021 Cite

Head Model for Entire Brain Deformation Calculation in Real-time with Machine Learning

Conference Conference Proceedings International Research Council on the Biomechanics of Injury Ircobi · January 1, 2021 Cite

High-resolution 3D volumetric contrast-enhanced MR angiography with a blood pool agent (ferumoxytol) for diagnostic evaluation of pediatric brain arteriovenous malformations.

Conference J Neurosurg Pediatr · September 2018 OBJECTIVE Patients with brain arteriovenous malformations (AVMs) often require repeat imaging with MRI or MR angiography (MRA), CT angiography (CTA), and digital subtraction angiography (DSA). The ideal imaging modality provides excellent vascular visualiz ... Full text Link to item Cite

Engineered knottin peptide-drug conjugates selectively deliver small molecules to brain tumors in mice

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 13, 2016 Link to item Cite

HUMAN TOLERANCE TO MILD TRAUMA IN MULTIPLE DIMENSIONS

Conference JOURNAL OF NEUROTRAUMA · March 1, 2014 Link to item Cite

Controlled synthesis of gold nanorods and application to brain tumor delineation

Conference Optics InfoBase Conference Papers · December 1, 2011 Gold nanorods are candidates for tumor delineation due to their unique optical properties and biocompatibility. The optical characteristics of nanorods are tuned during synthesis. Anti-EGFR nanorods effectively label tumors within brain slices. © 2011 OSA. ... Cite

Intracranial dual-mode IVUS and hyperthermia using circular arrays

Conference IEEE International Ultrasonics Symposium Ius · December 1, 2011 In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS ca ... Full text Cite

Controlled synthesis of gold nanorods and application to brain tumor delineation

Conference Optics Infobase Conference Papers · January 1, 2011 Gold nanorods are candidates for tumor delineation due to their unique optical properties and biocompatibility. The optical characteristics of nanorods are tuned during synthesis. Anti-EGFR nanorods effectively label tumors within brain slices. © 2011 OSA. ... Full text Cite

Intracranial catheter for integrated 3D ultrasound imaging & hyperthermia: Feasibility study

Conference Aip Conference Proceedings · July 21, 2009 In this study, we investigated the feasibility of an intracranial catheter transducer capable of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. We designed and constructed ... Full text Cite