Giselle Yvette Lopez | Scholars@Duke

Giselle Yvette Lopez
Assistant Professor in Pathology

I am a physician scientist with a clinical focus on neuropathology, and a research interest in brain tumors. Originally from Maryland, I completed my undergraduate training at the University of Maryland, completing degrees in Physiology and Neurobiology as well as Spanish Language and Literature. I subsequently came to Duke for my MD and PhD, and discovered a passion for brain tumor research, and quickly realized that this was my life's calling. After completing a residency and fellowship at the University of California, San Francisco, I returned to Duke as an Assistant Professor of Pathology. Clinically, I now specialize in neuropathology, with my research focusing on brain tumors of all types. By better understanding these tumors, I hope to identify new ways to treat these tumors and improve the lives of patients with brain tumors.

Current Appointments & Affiliations

Assistant Professor in Pathology, Pathology, Clinical Science Departments 2021
Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

214MC Green Zone, Duke South, DUMC Box 3712, Durham, NC 27710
Box 3712 Med Ctr, Durham, NC 27710
(919) 681-8291
Doximity
LinkedIn
Twitter

Background
Education, Training, & Certifications
- Fellowship, Neuropathology, University of California - San Francisco 2016 - 2018
- Residency, Anatomic Pathology, University of California - San Francisco 2014 - 2016
- Certificate, Cell And Molecular Biology, Duke University 2007 - 2014
- MD./PhD., Duke University School of Medicine 2014
- B.A., University of Maryland, College Park 2005
- B.S., University of Maryland, College Park 2005
Medical Licensure
- 2018-01474. North Carolina. 2018
- A142358. California. 2016
Duke Appointment History
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2018 - 2020
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2019 - 2020
Academic Positions Outside Duke
- Clinical Instructor, University of California, San Francisco. 2018
- Clinical Research Fellow, University of California, San Francisco. 2018
Recognition
Awards & Honors
Expertise
Subject Headings
Global Scholarship
- Research
  - United States of America (Country)
Research
Fellowships, Supported Research, & Other Grants
- Training Program in Translational Brain Tumor Research awarded by National Cancer Institute 2018
- Honors Research Grant awarded by University of Maryland 2005
- Senior Summer Scholar awarded by University of Maryland 2004
- HHMI Undergraduate Research Fellowship awarded by Howard Hughes Medical Institute 2003 - 2005
External Relationships
- Caris Life Sciences
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ahn, Janice S., Maureen Petersen, Allan H. Friedman, Edward M. López, Thomas J. Cummings, Anne F. Buckley, and Giselle Y. López. “Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.” Ultrastruct Pathol 44, no. 4–6 (November 20, 2020): 511–18. https://doi.org/10.1080/01913123.2020.1843578.
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  - Shen, Erica, Joanne Xiu, Rex Bentley, Giselle Y. López, and Kyle M. Walsh. “Frequent Mutations of POT1 Distinguish Pulmonary Sarcomatoid Carcinoma From Other Lung Cancer Histologies.” Clin Lung Cancer 21, no. 6 (November 2020): e523–27. https://doi.org/10.1016/j.cllc.2020.04.002.
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  - Shen, Erica, Joanne Xiu, Giselle Y. Lopez, Rex Bentley, Ali Jalali, Amy B. Heimberger, Matthew N. Bainbridge, Melissa L. Bondy, and Kyle M. Walsh. “POT1 mutation spectrum in tumour types commonly diagnosed among POT1-associated hereditary cancer syndrome families.” J Med Genet 57, no. 10 (October 2020): 664–70. https://doi.org/10.1136/jmedgenet-2019-106657.
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  - Tan, Aaron C., David M. Ashley, Giselle Y. López, Michael Malinzak, Henry S. Friedman, and Mustafa Khasraw. “Management of glioblastoma: State of the art and future directions.” Ca Cancer J Clin 70, no. 4 (July 2020): 299–312. https://doi.org/10.3322/caac.21613.
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  - Fan, Joline M., David A. Solomon, Giselle Y. López, Jeffrey W. Hofmann, Rene A. Colorado, Anthony S. Kim, Karl Meisel, and Cathra Halabi. “Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report.” Bmc Neurol 20, no. 1 (March 21, 2020): 106. https://doi.org/10.1186/s12883-020-01681-9.
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  - Wilfong, Erin M., Roxanne Croze, Xiaohui Fang, Matthew Schwede, Erene Niemi, Giselle Y. López, Jae-Woo Lee, Mary C. Nakamura, and Michael A. Matthay. “Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.” Plos One 15, no. 10 (2020): e0240319. https://doi.org/10.1371/journal.pone.0240319.
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  - López, G. Y., A. Perry, B. Harding, M. Li, and M. Santi. “CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.” Neuropathol Appl Neurobiol 45, no. 2 (February 2019): 174–78. https://doi.org/10.1111/nan.12503.
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  - López, Giselle Y., Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Iwei Yeh, Boris C. Bastian, Jennifer Clarke, et al. “The genetic landscape of gliomas arising after therapeutic radiation.” Acta Neuropathol 137, no. 1 (January 2019): 139–50. https://doi.org/10.1007/s00401-018-1906-z.
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  - Safaee, Michael M., Soren Jonzzon, Giselle Y. López, Shailesh Asaikar, Tarik Tihan, Orit A. Glenn, and Nalin Gupta. “Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features.” J Neurosurg Pediatr 22, no. 5 (November 1, 2018): 528–31. https://doi.org/10.3171/2018.5.PEDS18104.
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  - Vitt, Jeffrey R., Collin Kreple, Nausheen Mahmood, Elliot Dickerson, Giselle Y. Lopez, and Megan B. Richie. “Autoimmune pancerebellitis associated with pembrolizumab therapy.” Neurology 91, no. 2 (July 10, 2018): 91–93. https://doi.org/10.1212/WNL.0000000000005781.
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  - Cheung, Hoiwan, Courtney Lawhn-Heath, Giselle Lopez, Maya Vella, and Carina Mari Aparici. “Metastatic cervical paravertebral solitary fibrous tumor detected by fluorodeoxyglucose positron emission tomography-computed tomography.” Radiol Case Rep 13, no. 2 (April 2018): 464–67. https://doi.org/10.1016/j.radcr.2018.01.027.
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  - Cordano, Christian, Giselle Y. López, Andrew W. Bollen, and Bardia Nourbakhsh. “Occipital Headache in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).” Headache 58, no. 3 (March 2018): 458–59. https://doi.org/10.1111/head.13232.
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  - Lopez, Giselle Y., Nancy Ann Oberheim Bush, Joanna J. Phillips, John-Paul Bouffard, Yaron A. Moshel, Kurt Jaeckle, B. K. Kleinschmidt-DeMasters, Marc K. Rosenblum, Arie Perry, and David A. Solomon. “Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression.” Acta Neuropathol 134, no. 6 (December 2017): 961–63. https://doi.org/10.1007/s00401-017-1780-0.
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  - López, Giselle, Nancy Ann Oberheim Bush, Mitchel S. Berger, Arie Perry, and David A. Solomon. “Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma.” Acta Neuropathol Commun 5, no. 1 (May 15, 2017): 38. https://doi.org/10.1186/s40478-017-0440-x.
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  - Lopez, Giselle, Roger E. McLendon, and Katherine B. Peters. “Supratentorial tanycytic ependymoma in an adult male: case report and review of literature.” Case Rep Oncol 8, no. 1 (January 2015): 159–63. https://doi.org/10.1159/000380906.
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  - Feng, Haizhong, Giselle Y. Lopez, Chung Kwon Kim, Angel Alvarez, Christopher G. Duncan, Ryo Nishikawa, Motoo Nagane, et al. “EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.” J Clin Invest 124, no. 9 (September 2014): 3741–56. https://doi.org/10.1172/JCI73093.
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  - López, G. Y., G. A. Grant, H. E. Fuchs, L. G. Leithe, S. Gururangan, D. D. Bigner, H. Yan, R. E. McLendon, and Y. He. “Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.” Neuropathol Appl Neurobiol 40, no. 2 (February 2014): 217–20. https://doi.org/10.1111/nan.12060.
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  - Jin, Genglin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B Ahmed Rasheed, Rui Yang, et al. “Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.” Cancer Res 73, no. 2 (January 15, 2013): 496–501. https://doi.org/10.1158/0008-5472.CAN-12-2852.
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  - Jin, Genglin, Christopher J. Pirozzi, Lee H. Chen, Giselle Y. Lopez, Christopher G. Duncan, Jie Feng, Ivan Spasojevic, Darell D. Bigner, Yiping He, and Hai Yan. “Mutant IDH1 is required for IDH1 mutated tumor cell growth.” Oncotarget 3, no. 8 (August 2012): 774–82. https://doi.org/10.18632/oncotarget.577.
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  - Jiao, Yuchen, Patrick J. Killela, Zachary J. Reitman, Ahmed B. Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, et al. “Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.” Oncotarget 3, no. 7 (July 2012): 709–22. https://doi.org/10.18632/oncotarget.588.
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  - Koivunen, Peppi, Sungwoo Lee, Christopher G. Duncan, Giselle Lopez, Gang Lu, Shakti Ramkissoon, Julie A. Losman, et al. “Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.” Nature 483, no. 7390 (February 15, 2012): 484–88. https://doi.org/10.1038/nature10898.
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  - Heibel, Sandra Kirsch, Giselle Yvette Lopez, Maria Panglao, Sonal Sodha, Leonardo Mariño-Ramírez, Mendel Tuchman, and Ljubica Caldovic. “Transcriptional regulation of N-acetylglutamate synthase.” Plos One 7, no. 2 (2012): e29527. https://doi.org/10.1371/journal.pone.0029527.
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  - Guo, Changcun, Christopher J. Pirozzi, Giselle Y. Lopez, and Hai Yan. “Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target.” Curr Opin Neurol 24, no. 6 (December 2011): 648–52. https://doi.org/10.1097/WCO.0b013e32834cd415.
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  - Degan, Simone, Giselle Y. Lopez, Katharine Kevill, and Mary E. Sunday. “Gastrin-releasing peptide, immune responses, and lung disease.” Ann N Y Acad Sci 1144 (November 2008): 136–47. https://doi.org/10.1196/annals.1418.022.
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  - Caldovic, Ljubica, Giselle Y. Lopez, Nantaporn Haskins, Maria Panglao, Dashuang Shi, Hiroki Morizono, and Mendel Tuchman. “Biochemical properties of recombinant human and mouse N-acetylglutamate synthase.” Mol Genet Metab 87, no. 3 (March 2006): 226–32. https://doi.org/10.1016/j.ymgme.2005.10.003.
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  - Caldovic, Ljubica, Hiroki Morizono, Maria G. Panglao, Giselle Y. Lopez, Dashuang Shi, Marshall L. Summar, and Mendel Tuchman. “Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles.” Hum Mutat 25, no. 3 (March 2005): 293–98. https://doi.org/10.1002/humu.20146.
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- Book Sections
  - López, G. Y., M. Samsky, R. Jones, C. Adamson, and H. Yan. “Genetic alterations in glioblastoma multiforme.” In Systems Biology of Cancer, 323–44, 2015. https://doi.org/10.1017/9780511979811.022.
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- Conference Papers
  - Feng, H., G. Lopez, C. K. Kim, A. Alvarez, C. Duncan, R. Nishikawa, M. Nagane, et al. “CS-06 * EGFR PHOSPHORYLATION OF DCBLD2 RECRUITS TRAF6 AND STIMULATES Akt-PROMOTED TUMORIGENESIS.” In Neuro Oncology, 16:v52–v52. Oxford University Press (OUP), 2014. https://doi.org/10.1093/neuonc/nou242.6.
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  - Cheng, S., H. Feng, G. Y. Lopez, C. K. Kim, C. G. Duncan, A. Alvarez, R. Nishikawa, et al. “EGFR PHOSPHORYLATION OF DCBLD2 RECRUITS TRAF6 AND STIMULATES AKT-PROMOTED TUMORIGENESIS.” In Neuro Oncology, 16:iii16–17. Oxford University Press (OUP), 2014. https://doi.org/10.1093/neuonc/nou206.60.
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Teaching & Mentoring
Recent Courses
- PATHOL 855S: Graduate Seminar in Pathology 2020
Advising & Mentoring
- - 2017-2018 Chair, Mentoring Committee, Graduate Medical Education Diversity Advisory Group, University of California, San Francisco
  - Medical Students: I have served as a mentor to medical students at the University of California, San Francisco
  - Undergraduate Students: During graduate school, I mentored an undergraduate student, who is now a successful medical student.
Teaching Activities
- - 2009-2011: Teaching Assistant, PATH385: Molecular Aspects of Disease, Duke University
  - 2014-2018: Medical Student Pathology Course Discussion Leader, various small group sessions, University of California, San Francisco
  - 2017: Development of online learning module on Normal Brain Histology, University of California, San Francisco
Scholarly, Clinical, & Service Activities
Service to the Profession
Service to Duke
Academic & Administrative Activities
- - 2020- Co-Chair, Diversity and Inclusion Committee, Pathology PhD Program, Duke University
  - 2017-2018 Member, Executive Medical Board, University of California, San Francisco
  - 2017-2018 Member, Graduate Medical Education Committee, University of California, San Francisco
  - 2017-2018 Co-Chair, Resident and Fellows' Council, University of California, San Francisco
  - 2017-2018 Co-Chair, Research Interest Group, Department of Pathology, University of California, San Francisco
Clinical Activities
- My clinical activities include surgical neuropathology, with a particular interest in brain tumors.

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Education, Training, & Certifications

Medical Licensure

Duke Appointment History

Academic Positions Outside Duke

Awards & Honors

Subject Headings

Global Scholarship

Research

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses

Advising & Mentoring

Teaching Activities

Service to the Profession

Service to Duke

Academic & Administrative Activities

Clinical Activities