ConferenceThe Journal of Immunology · August 1, 2026
AbstractIntroductionKey challenges in treating glioblastoma are the immunosuppressive tumor microenvironment and the blood-brai ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016
Image processing has become ubiquitous in imaging research - so ubiquitous that it is easy to loose track of how diverse this processing has become. The Duke Center for In Vivo Microscopy has pioneered the development of Magnetic Resonance Histology (MRH), ...
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Conference · October 26, 2015
The nondestructive study of plants and soils in situ has historically been difficult due to the inherently opaque nature of the system. Repeated study of root growth and physiological processes in bulk soil has been impossible without techniques for remote ...
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Conference2014 IEEE 11th International Symposium on Biomedical Imaging Isbi 2014 · July 29, 2014
While helical scanning is well established in the clinical arena, most micro-CT scanners use circular cone beam trajectories and approximate reconstructions based on a filtered backprojection (FBP) algorithm. This may be sufficient for some applications, b ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014
In preclinical research, micro-CT is commonly used to provide anatomical information; however, there is significant interest in using this technology to obtain functional information in cardiac studies. The fastest acquisition in 4D cardiac micro-CT imagin ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014
There is ongoing interest in extending CT from anatomical to functional imaging. Recent successes with dual energy CT, the introduction of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast agents enable functional ima ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014
To match recent clinical dual energy (DE) CT studies focusing on the lung, similar developments for DE micro-CT of the rodent lung are required. Our group has been actively engaged in designing pulmonary gating techniques for micro- CT, and has also introd ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · June 3, 2013
Dual energy (DE) CT imaging is expected to play a major role in the diagnostic arena as it provides a quantitative decomposition of basis materials, opening the door for new clinical applications without significantly increasing dose to the patient. DE-CT ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 4, 2012
Micro-CT has become a powerful tool for small animal research. Many micro-CT applications require exogenous contrast agents, which are most commonly based on iodine. Despite advancements in contrast agents, single-energy micro-CT is sometimes limited in th ...
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ConferenceProc SPIE Int Soc Opt Eng · February 23, 2012
Bilateral filtration has proven an effective tool for denoising CT data. The classic filter utilizes Gaussian domain and range weighting functions in 2D. More recently, other distributions have yielded more accurate results in specific applications, and th ...
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ConferenceProc SPIE Int Soc Opt Eng · 2012
X-ray Luminescence CT (XLCT) is a hybrid imaging modality combining x-ray and optical imaging in which x-ray luminescent nanophosphors (NPs) are used as emissive imaging probes. NPs are easily excited using common CT energy x-ray beams, and the NP luminesc ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 13, 2011
Spectral CT imaging is expected to play a major role in the diagnostic arena as it provides material decomposition on an elemental basis. One fascinating possibility is the ability to discriminate multiple contrast agents targeting different biological sit ...
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ConferenceProgress in Biomedical Optics and Imaging - Proceedings of SPIE · 2010
Dynamic imaging with micro-CT often produces poorly-distributed sets of projections, and reconstructions of this data with filtered backprojection algorithms (FBP) may be affected by artifacts. Iterative reconstruction algorithms and total variation (TV) d ...
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ConferenceProc SPIE Int Soc Opt Eng · 2010
Image reconstruction is one of the main challenges for fluorescence tomography. For in vivo experiments on small animals, in particular, the inhomogeneous optical properties and irregular surface of the animal make free-space image reconstruction challengi ...
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Conference2010 7th IEEE International Symposium on Biomedical Imaging from Nano to Macro Isbi 2010 Proceedings · January 1, 2010
Magnetic Resonance Imaging (MRI) has exhibited significant potential for quantifying cardiac function and dysfunction in the mouse. Recent advances in highresolution cardiac MR imaging techniques have contributed to the development of acquisition approache ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · June 15, 2009
The attenuation of x-rays in matter is dependent on the energy of the x-rays and the atomic composition of the matter. Attenuation measurements at multiple x-ray energies can be used to improve the identification of materials. We present a method to estima ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · June 15, 2009
Quantitative in-vivo imaging of lung perfusion in rodents can provide critical information for preclinical studies. However, the combined challenges of high temporal and spatial resolution have made routine quantitative perfusion imaging difficult in roden ...
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ConferenceProc SPIE Int Soc Opt Eng · February 16, 2009
Fluorescence imaging is an important tool for tracking molecular-targeting probes in preclinical studies. It offers high sensitivity, but nonetheless low spatial resolution compared to other leading imaging methods such CT and MRI. We demonstrate our metho ...
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ConferenceProc SPIE Int Soc Opt Eng · April 18, 2008
Micro-CT is a non-invasive imaging modality usually used to assess morphology in small animals. In our previous work, we have demonstrated that functional micro-CT imaging is also possible. This paper describes a dual micro-CT system with two fixed x-ray/d ...
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ConferenceProceedings of the 3rd International IEEE EMBS Conference on Neural Engineering · September 25, 2007
Many research efforts using anatomical image analysis have as their goal to identify biologically relevant objects present within the image data, to provide a means to quantitatively analyze these objects, to compare the distribution of those objects to ot ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · January 1, 2007
In vivo quantitative studies of cardiac function in mouse models provide information about cardiac pathophysiology in more detail than can be obtained in humans. Quantitative measurements of left ventricular (LV) volume at multiple contractile phases are p ...
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ConferenceMedical Physics · January 1, 2006
The first day of the Molecular Imaging Symposium (MI‐1) will focus on the technology aspects of molecular, functional, and small animal imaging. Modalities which will be discussed include micro‐CT, micro‐PET, and high resolution MRI for small animal imagin ...
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Conference2006 3rd IEEE International Symposium on Biomedical Imaging from Nano to Macro Proceedings · January 1, 2006
Vascular tonicity plays a major role in regulating the blood pressure and the perfusion of organs, and hypertension is a major cause of morbidity and mortality in humans. We use phenylephrine, a vasoconstrictor, to create a model of hypertension in the rat ...
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Conference2006 3rd IEEE International Symposium on Biomedical Imaging from Nano to Macro Proceedings · January 1, 2006
The high spatial and temporal resolution demands for imaging physiological function in the rodent call for the use of novel ways to combine information from different imaging modalities. This work describes ventilation imaging using hyperpolarized (HP)
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Conference2006 3rd IEEE International Symposium on Biomedical Imaging from Nano to Macro Proceedings · January 1, 2006
We propose the use of Tomographic Digital Subtraction Angiography (TDSA) for functional imaging in small animals. TDSA combines the advantages of high temporal resolution of digital subtraction angiography (DSA) and high spatial resolution of micro-compute ...
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ConferenceProc Am Thorac Soc · 2005
Small-animal imaging with magnetic resonance microscopy (MRM) has become an important tool in biomedical research. When MRM is used to image perfusion-fixed and "stained" whole mouse specimens, cardiopulmonary morphology can be visualized, nondestructively ...
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ConferenceIEEE Nuclear Science Symposium Conference Record · January 1, 2004
This paper investigates the potential of magnetic resonance imaging (MRI) to improve the estimation of within-tumor variations in F18-FDG concentration. An image model is described for incorporating MRI images into positron emission tomography (PET) and si ...
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Conference2004 2nd IEEE International Symposium on Biomedical Imaging Macro to Nano · January 1, 2004
The availability of genetically altered mouse models of human disease and the increasing use of small animals in basic research have spurred extraordinary interest in new imaging methodologies - particularly magnetic resonance microscopy, microCT, and micr ...
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Conference2004 2nd IEEE International Symposium on Biomedical Imaging Macro to Nano · January 1, 2004
Two of the major barriers to improved image quality in micro-CT are the reduced signal to noise imposed by the smaller voxels and the effects of physiologic motion. The most direct approach to increase the signal to noise ratio (SNR) is to increase the flu ...
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Conference2004 2nd IEEE International Symposium on Biomedical Imaging Macro to Nano · January 1, 2004
Magnetic resonance microscopy is capable of producing high-resolution pulmonary images in live rodents by synchronizing the image acquisition across multiple breaths. The precision with which one can control motion will probably define the resolution limit ...
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ConferenceProceedings Applied Imagery Pattern Recognition Workshop · January 1, 2001
We describe a networked environment for navigating and visualizing 3-dimensional anatomical data with extensions for time varying volumes. The Duke Center for In Vivo Microscopy (CIVM) has been capturing volumetric data of mice using magnetic resonance mic ...
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ConferenceProceedings of SPIE the International Society for Optical Engineering · August 18, 1980
Recent work has suggested a new approach to film/screen mammography through the use of transmolybdenum (Z > 42) fluorescent anodes. An experimental rhodium (Z = 45) anode with K emission at 20.0 - 23.2 keV has been compared to a conventional molybdenum ano ...
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