Donald D. Glower Jr.

Journal article J Card Surg · April 2021 Featured Work BACKGROUND: Port-access (PORT) and robotic (ROBO) mitral repair are well established, but differences in patient selection and outcomes are not well documented. METHODS: A retrospective analysis was performed on 129 ROBO and 628 PORT mitral repairs at one ... Full text Open Access Link to item Cite

Five-year outcomes of transcatheter reduction of significant mitral regurgitation in high-surgical-risk patients.

Journal article Heart · November 2019 Featured Work OBJECTIVES: This study evaluates the 5-year clinical outcomes of transcatheter mitral valve (MV) repair with the MitraClip device in patients at high risk for MV surgery treated in the Endovascular Valve Edge-to-Edge Repair (EVEREST) II High Risk Study (HR ... Full text Link to item Cite

Institutional Experience With Transcatheter Mitral Valve Repair and Clinical Outcomes: Insights From the TVT Registry.

Journal article JACC Cardiovasc Interv · July 22, 2019 Featured Work OBJECTIVES: The aim of this study was to examine the relation between institutional experience and procedural results of transcatheter mitral valve repair. BACKGROUND: Transcatheter mitral valve repair for the treatment of mitral regurgitation (MR) is a co ... Full text Link to item Cite

Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation.

Journal article J Am Coll Cardiol · May 21, 2019 Featured Work BACKGROUND: The incidence of permanent pacemaker (PPM) implantation is higher following mitral valve surgery (MVS) with ablation for atrial fibrillation (AF) compared with MVS alone. OBJECTIVES: This study identified risk factors and outcomes associated wi ... Full text Link to item Cite

One-Year Outcomes After MitraClip for Functional Mitral Regurgitation.

Journal article Circulation · January 2, 2019 Featured Work BACKGROUND: Secondary mitral regurgitation (SMR) occurs in the absence of organic mitral valve disease and may develop as the left ventricle dilates or remodels or as a result of leaflet tethering with impaired coaptation, most commonly from apical and lat ... Full text Link to item Cite

Robotic Mitral Valve Repair in Older Individuals: An Analysis of The Society of Thoracic Surgeons Database.

Journal article Ann Thorac Surg · November 2018 Featured Work BACKGROUND: National outcomes of robotic mitral valve repair (rMVr) compared with sternotomy (sMVr) in older patients are currently unknown. METHODS: From 2011 to 2014, all patients aged 65 years and older undergoing MVr in The Society of Thoracic Surgeons ... Full text Open Access Link to item Cite

Long-term outcomes of mitral regurgitation by type and severity.

Journal article Am Heart J · September 2018 Featured Work BACKGROUND: We aimed to determine the association of MR severity and type with all-cause death in a large, real-world, clinical setting. METHODS: We reviewed full echocardiography studies at Duke Echocardiography Laboratory (01/01/1995-12/31/2010), classif ... Full text Link to item Cite

Using a Regent Aortic Valve in a Small Annulus Mitral Position Is a Viable Option.

Journal article Ann Thorac Surg · April 2018 Featured Work BACKGROUND: Outcome of mitral valve replacement in extreme scenarios of small mitral annulus with the use of the Regent mechanical aortic valve is not well documented. METHODS: Records were examined in 31 consecutive patients who underwent mitral valve rep ... Full text Open Access Link to item Cite

Minimally Invasive Mitral Repair: Direct Aortic Cannulation Via Right 2nd Intercostal Space.

Journal article Innovations (Phila) · 2018 Featured Work The right 2nd interspace minithoracotomy has advantages over femoral arterial cannulation providing an alternative that should be in the arsenal of the minimally invasive surgeon; we describe here the method, the advantages, and the pitfalls. ... Full text Link to item Cite

Catastrophic antiphospholipid syndrome after cardiac surgery.

Journal article J Card Surg · September 2016 Featured Work We report a case of catastrophic antiphospholipid syndrome in a patient following mitral valve replacement. The pathophysiology and management of this rare condition is discussed. ... Full text Link to item Cite

Trans-aortic Alfieri stitch at the time of septal myectomy for hypertrophic obstructive cardiomyopathy.

Journal article J Card Surg · August 2016 Featured Work BACKGROUND: Systolic anterior motion (SAM) of the mitral valve, left ventricular outflow tract (LVOT) obstruction, and mitral regurgitation (MR) are known adverse outcomes that can occur after septal myectomy for hypertrophic obstructive cardiomyopathy. Th ... Full text Link to item Cite

Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation: 5-Year Results of EVEREST II.

Journal article J Am Coll Cardiol · December 29, 2015 Featured Work BACKGROUND: In EVEREST II (Endovascular Valve Edge-to-Edge Repair Study), treatment of mitral regurgitation (MR) with a novel percutaneous device showed superior safety compared with surgery, but less effective reduction in MR at 1 year. OBJECTIVES: This s ... Full text Link to item Cite

MitraClip (R) for Functional Mitral Regurgitation: Outcomes in Over 600 Patients

Journal article CIRCULATION · November 10, 2015 Featured Work Link to item Cite

Right Minithoracotomy Versus Median Sternotomy for Mitral Valve Surgery: A Propensity Matched Study.

Journal article Ann Thorac Surg · August 2015 Featured Work BACKGROUND: The efficacy of conventional median sternotomy versus a right minithoracotomy (RT) approach to mitral valve surgery was evaluated in a single high-volume institution. METHODS: A retrospective analysis of a single institution's experience was pe ... Full text Open Access Link to item Cite

Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: results of the EVEREST II study.

Journal article J Am Coll Cardiol · July 15, 2014 Featured Work BACKGROUND: The EVEREST II (Endovascular Valve Edge-to-Edge REpair STudy) High-Risk registry and REALISM Continued Access Study High-Risk Arm are prospective registries of patients who received the MitraClip device (Abbott Vascular, Santa Clara, California ... Full text Link to item Cite

Twenty-five-year outcomes after multiple internal thoracic artery bypass.

Journal article J Thorac Cardiovasc Surg · April 2013 Featured Work OBJECTIVE: Coronary artery bypass grafting with multiple internal thoracic artery grafts is currently controversial. This study assessed single institutional outcomes with multiple internal thoracic artery grafting for guidance with future clinical decisio ... Full text Link to item Cite

Minimally invasive edge-to-edge mitral repair with or without artificial chordae.

Journal article Ann Thorac Surg · April 2013 Featured Work BACKGROUND: This study aims to analyze the midterm outcomes of minimally invasive edge-to-edge mitral valve repair (MVR) with artificial chords (CHORD) or without artificial chords (noCHORD) in patients with mitral regurgitation (MR). METHODS: Records of a ... Full text Link to item Cite

Minithoracotomy versus sternotomy for mitral surgery in patients with chronic renal impairment: a propensity-matched study.

Journal article Innovations (Phila) · 2013 Featured Work OBJECTIVE: Compared with median sternotomy, a right thoracotomy (RT) approach to mitral surgery is associated with decreased postoperative acute renal failure. Therefore, we examined propensity-matched patients with chronic renal impairment to compare outc ... Full text Link to item Cite

Results of 141 consecutive minimally invasive tricuspid valve operations: an 11-year experience.

Journal article Ann Thorac Surg · December 2009 Featured Work BACKGROUND: Reports of minimally invasive tricuspid valve operations are rare. We reviewed our experience and results of tricuspid valve operation using mini-thoracotomy during an 11-year period. METHODS: Consecutive patients (n = 141) undergoing tricuspid ... Full text Link to item Cite

Mitral valve repair for degenerative disease: a 20-year experience.

Journal article Ann Thorac Surg · December 2009 Featured Work BACKGROUND: Recent advances in surgical technique allow repair of most mitral valves with degenerative disease. However, few long-term data exist to support the superiority of repair versus prosthetic valve replacement, and repair could be limited by late ... Full text Link to item Cite

Pure annular dilation as a cause of mitral regurgitation: a clinically distinct entity of female heart disease.

Journal article J Heart Valve Dis · May 2009 Featured Work BACKGROUND AND AIM OF THE STUDY: Pure annular dilation (PAD) is a recognized etiology of mitral regurgitation, yet few data exist to define the prognostic profile of this disorder relative to other etiologies, such as ischemia or myxomatous prolapse. METHO ... Link to item Cite

Survival prognosis and surgical management of ischemic mitral regurgitation.

Journal article Ann Thorac Surg · September 2008 Featured Work BACKGROUND: Ischemic mitral regurgitation (IMR) has an adverse prognosis, but survival characteristics and management are controversial. This study reviewed a 20-year series of IMR patients managed with multiple approaches to assess and refine surgical str ... Full text Link to item Cite

Minitransseptal versus left atrial approach to the mitral valve: a comparison of outcomes.

Journal article Ann Thorac Surg · September 2006 Featured Work BACKGROUND: Approaches to the mitral valve include left atriotomy (LA) through the interatrial groove and transseptal approach (TS) through the right atrium. Left atriotomy is more commonly used, but TS offers better mitral visualization in difficult cases ... Full text Link to item Cite

Determinants of operative mortality in valvular heart surgery.

Journal article J Thorac Cardiovasc Surg · March 2006 Featured Work OBJECTIVE: In some respects, outcome reporting in valvular surgery has been hampered by focusing on specific populations, reluctance to publish high-risk subgroups, and possibly skewed or inadequate samples. The goal of this study was to evaluate risk fact ... Full text Link to item Cite

Patient survival characteristics after routine mitral valve repair for ischemic mitral regurgitation.

Journal article J Thorac Cardiovasc Surg · April 2005 Featured Work BACKGROUND: Ischemic mitral regurgitation has been associated with diminished survival compared with nonischemic mitral regurgitation. Conversion from mitral valve replacement to valve repair has improved prognosis, but it is unclear whether ischemic mitra ... Full text Link to item Cite

Management of Chronic Aortic Regurgitation.

Journal article Curr Treat Options Cardiovasc Med · December 2003 Featured Work Aortic regurgitation may be the most treacherous of the valvular lesions due to subtlety of symptoms and physical findings and due to difficulty in timing surgical intervention to prevent permanent cardiac dysfunction. Cardiac imaging (eg, echocardiography ... Full text Link to item Cite

Survival after coronary revascularization, with and without mitral valve surgery, in patients with ischemic mitral regurgitation.

Journal article Circulation · September 9, 2003 Featured Work BACKGROUND: The most appropriate treatment for patients with ischemic mitral regurgitation (IMR) is often debated. We compared the survival rates of patients with IMR undergoing different treatment strategies, namely: medical therapy, percutaneous coronary ... Full text Link to item Cite

Mitral valve surgery and acute renal injury: port access versus median sternotomy.

Journal article Ann Thorac Surg · March 2003 Featured Work BACKGROUND: Many outcomes and complications of minimally invasive and conventional cardiac surgery await comparison. Patients undergoing mitral valve surgery commonly sustain renal injury. Using peak postoperative fractional change of serum creatinine as a ... Full text Link to item Cite

Mitral surgery after prior cardiac operation: port-access versus sternotomy or thoracotomy.

Journal article Ann Thorac Surg · October 2002 Featured Work BACKGROUND: In reoperation for mitral valve disease, minimally invasive Port-Access (PORT) is a new alternative to standard median sternotomy (STER) or right thoracotomy (THOR); yet, the results of PORT in this setting have not been defined. The aim of thi ... Full text Link to item Cite

Minimally invasive tricuspid operation using port access.

Journal article Ann Thorac Surg · July 2002 Featured Work BACKGROUND: Port-access techniques performed through a right mini-thoracotomy have been extensively described for both the mitral and aortic valves. However, reports of tricuspid valve operations using the port-access approach are rare. A technique for min ... Full text Link to item Cite

Port-access approach for combined aortic and mitral valve surgery.

Journal article Ann Thorac Surg · May 2002 Featured Work A technique is described for combined aortic and mitral valve operation utilizing the minimally invasive Port-Access technique. Two patients are repaired with excellent chest wall healing and avoidance of sternotomy. ... Full text Link to item Cite

Comparison of port access to sternotomy in tricuspid or mitral/tricuspid operations.

Journal article Heart Surg Forum · 2002 Featured Work BACKGROUND: Outcomes for a port-access (PA) approach for tricuspid valve operations have not been reported or compared to those using median sternotomy (MS). METHODS: Retrospective analysis was performed for 88 consecutive patients undergoing tricuspid val ... Link to item Cite

Comparison of survival after mitral valve replacement with biologic and mechanical valves in 1139 patients.

Journal article J Thorac Cardiovasc Surg · September 2001 Featured Work OBJECTIVE: We sought to compare 10-year survival in patients after mitral valve replacement with biologic or mechanical valve prostheses. METHODS: Retrospective survival analysis was performed on data from 1139 consecutive patients older than 18 years of a ... Full text Link to item Cite

Predictors of operative time in multicenter port-access valve registry: institutional differences in learning.

Journal article Heart Surg Forum · 2001 Featured Work BACKGROUND: The predictors of operative time and the effects of learning in isolated valve operations using port-access techniques have not been defined. METHODS: Analysis of covariance was used to examine the determinants of procedure time, pump time, and ... Link to item Cite

Comparison of direct aortic and femoral cannulation for port-access cardiac operations.

Journal article Ann Thorac Surg · October 1999 Featured Work BACKGROUND: Differences in outcome after direct aortic cannulation (AORT) in the chest versus standard femoral arterial cannulation (FEM) have not been defined for minimally invasive cardiac operations utilizing the port-access approach. METHODS: A retrosp ... Full text Link to item Cite

Long-term outcome after biologic versus mechanical aortic valve replacement in 841 patients.

Journal article J Thorac Cardiovasc Surg · May 1999 Featured Work OBJECTIVE: The purpose of this study was to optimize selection criteria of biologic versus mechanical valve prostheses for aortic valve replacement. METHODS: Retrospective analysis was performed for 841 patients undergoing isolated, first-time aortic valve ... Full text Link to item Cite

Does pregnancy affect the durability of valvular bioprostheses?

Other Am Heart J · April 1999 Featured Work Full text Link to item Cite

First report of the Port Access International Registry.

Journal article Ann Thorac Surg · January 1999 Featured Work BACKGROUND: For minimally invasive cardiac operations to be widely applicable, the risks must be equivalent to those of standard open-chest operations. This study analyzed the outcomes of patients recorded in the multicenter Port Access (PA) International ... Full text Link to item Cite

Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves.

Journal article Ann Thorac Surg · December 1998 Featured Work BACKGROUND: The determinants of long-term outcome 15 years or more after porcine valve replacement are poorly documented. METHODS: A retrospective review was performed of patients undergoing valve replacement with standard Carpentier-Edwards aortic (n = 53 ... Full text Link to item Cite

Comparison of open mitral commissurotomy with mitral valve replacement with or without chordal preservation in patients with mitral stenosis.

Journal article Circulation · November 10, 1998 Featured Work BACKGROUND: Percutaneous balloon mitral valvuloplasty and durable mitral prostheses have made the role of open mitral commissurotomy (OMC) uncertain. METHODS AND RESULTS: Results from the use of St Jude mitral valve replacement (SJMVR) were compared with t ... Link to item Cite

Mitral valve operation via Port Access versus median sternotomy.

Journal article Eur J Cardiothorac Surg · October 1998 Featured Work OBJECTIVE: The advantages and disadvantages of minimally invasive Port Access mitral valve operation have not been defined relative to standard median sternotomy. A study was therefore designed to delineate differences in outcome from mitral operation via ... Full text Link to item Cite

Results of valve replacement with mechanical and biological prostheses in chronic renal dialysis patients.

Journal article Ann Thorac Surg · July 1997 Featured Work BACKGROUND: Whether biological or mechanical valves should be used in patients on chronic dialysis therapy remains to be clearly defined. METHODS: A retrospective review was performed on 19 consecutive patients from our institution with end-stage renal dis ... Full text Link to item Cite

Comparison of anticoagulation regimens after Carpentier-Edwards aortic or mitral valve replacement.

Journal article Circulation · November 1994 Featured Work BACKGROUND: To identify the optimal use of anticoagulants after Carpentier-Edwards valve replacement, a retrospective study of all patients undergoing Carpentier-Edwards aortic (N = 378) or mitral (N = 370) valve replacement was done. METHODS AND RESULTS: ... Link to item Cite

Determinants of reoperation after 960 valve replacements with Carpentier-Edwards prostheses.

Journal article J Thorac Cardiovasc Surg · February 1994 Featured Work During the period of 1977 to 1990, 960 Carpentier-Edwards standard prostheses (Baxter Healthcare Corp., Santa Ana, Calif.) were placed in 875 operations. Freedom from reoperation at 10 years was 57% +/- 4%, 76% +/- 3%, and 95% +/- 5% for mitral, aortic, an ... Link to item Cite

Mechanical correlates of the third heart sound.

Journal article J Am Coll Cardiol · February 1992 Featured Work In seven chronically instrumented conscious dogs, micromanometers measured left ventricular pressure, and ultrasonic dimension transducers measured left ventricular minor-axis diameter; the latter recording was filtered to examine data between 20 and 100 H ... Full text Link to item Cite

Management and long-term outcome of aortic dissection.

Journal article Ann Surg · July 1991 Featured Work All 163 patients admitted to one institution between 1975 and 1988 with aortic dissection were reviewed. Type I and type II patients received grafting of the ascending aorta, with an intraoperative mortality rate of 11%. For type III dissection, management ... Full text Link to item Cite

Comparison of medical and surgical therapy for uncomplicated descending aortic dissection.

Journal article Circulation · November 1990 Featured Work To guide the choice of medical versus surgical therapy for patients with descending (type B) aortic dissection (tear in the descending aorta without involvement of the ascending aorta), multivariate survival analysis was applied to 136 patients admitted to ... Link to item Cite

Clinical evaluation of single versus multiple mammary artery bypass.

Journal article Circulation · November 1990 Featured Work The superior patency and clinical advantages of internal mammary artery (IMA) grafting are well established. However, the relative benefits of routine multiple IMA grafting remain uncertain. To determine whether routine multiple compared with single IMA ut ... Link to item Cite

The influence of manual chest compression rate on hemodynamic support during cardiac arrest: high-impulse cardiopulmonary resuscitation.

Journal article Circulation · December 1986 Featured Work Considerable effort has been expended in recent years by a number of laboratories to improve methods of cardiopulmonary resuscitation. This article briefly summarizes 5 years of investigation by our group on hemodynamic support during external cardiac mass ... Link to item Cite

Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work.

Journal article Circulation · May 1985 Featured Work The Frank-Starling relationship generally has been examined with filling pressure as the index of preload, resulting in a curvilinear function that plateaus at higher filling pressures. To investigate this relationship further in the intact heart, 32 dogs ... Full text Link to item Cite

Port-Access Mitral Valve Surgery-An Evolution of Technique.

Journal article Semin Thorac Cardiovasc Surg Featured Work Port-access mitral valve surgery has been around since 1995; and many variations upon the technique have been developed. Since 1996, we have performed more than 2500 port-access mitral valve surgeries, and thus gained a substantial experience. The purpose ... Full text Open Access Link to item Cite