Goldis Malek

Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology

Ophthalmology, Vitreoretinal Diseases & Surgery

gmalek@duke.edu

https://orcid.org/0000-0003-0026-2388

Box 3802 Med Ctr, DUMC, Durham, NC 27710

Albert Eye Research Institute, Room 4006, Durham, NC 27710

More About This Person

At a Glance

Credentials
1. Education

Academic Experience

Global Scholarship

Keywords

Research
1. Selected Grants
2. External Relationships

Scholarly Works

Teaching & Mentoring
1. Recent Courses
2. Teaching Summary

Recognition
1. News Items

Professional Activities
1. Duke Initiatives

Scholarly Works - Conferences

Identification of disease associated endpoints in a mouse model exhibiting AMD-like pathology with age

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2022 Link to item Cite

Morphological and functional effects of nicotinamide on primary RPE cells derived from old donors

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2022 Link to item Cite

Nuclear Receptor Atlas of the Choroid: Implications for Disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2022 Link to item Cite

Aryl hydrocarbon receptor (AHR): potential link between autophagy and inflammation in retinal pigment epithelial (RPE) cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2021 Link to item Cite

Subchronic Fatty Diet Exacerbates Age-Related Macular Degneration (AMD) Phenotypes Associated with Impaired LXRa Signaling

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Nuclear Receptor Atlas of Human Choroidal Endothelium

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Thyroid Hormone Regulation of Retinal Pigment Epithelium Morphology and Survival

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Cooperative roles of NURR1 with RXR and LXR in retinal pigment epithelial (RPE) cells varies as a function of age and aged-related macular degeneration (AMD)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Identification of endpoints appropriate in evaluating potential therapeutics for retinal degenerations using apoB100 transgenic mice.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Downregulation of the SIRT1 and Liver X Receptor alpha/beta signaling axis promotes diabetic retinopathy pathogenesis

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Evaluating the efficacy of treatment with an LXR agonist on the pathogenesis of early AMD

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Aryl hydrocarbon receptor (AhR) activation decreases severity of laser-induced choroidal neovascular lesions (CNV)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Liver x receptors (LXR) at the intersection of lipid metabolism and inflammation: implications for age-related macular degeneration (AMD)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Investigating the role of peroxisome proliferator-activated receptor-beta/delta (PPAR beta/delta) in wet age-related macular degeneration (AMD)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Evaluation of the morphology of the mouse retinal pigment epithelium/bruch's membrane/choroid (RPE/BrM/Ch) using quick-freeze, deepetch transmission electron microscopy (QFDE-TEM) and conventional (cTEM).

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

The effect of pharmacologic activation of the aryl hydrocarbon receptor (AhR) on pathologies associated with age-related macular degeneration (AMD)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Targeting the peroxisome proliferator-activated receptor beta/delta ( PPAR beta/delta): Implications for dry and wet age-related macular degeneration (AMD)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Liver X Receptor signaling pathways and age-related macular degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Peroxisome proliferator-activated receptor (PPAR) beta/delta expression and activation in retinal pigment epithelial and choroidal endothelial cells: implication in age-related macular degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Aryl-hydrocarbon receptor plays a role in choroidal neovascularization by regulating endothelial migration and tube formation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Exploring Potential Differences in the Cell Energy Metabolism of Retinal Pigment Epithelial (RPE) Cell Culture Models

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite