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Jorg Grandl

Associate Professor of Neurobiology
Neurobiology
Box 3209 Med Ctr, Durham, NC 27710
Bryan Research Building, 311 Research Drive Room 327G, Durham, NC 27710

Scholarly Works - Book sections


Piezo Channels

Book section · January 1, 2023 Piezo1 and Piezo2 are mechanically activated nonselective cation channels. Piezos are found in protists, plants and all metazoans where they function as sensors of mechanical forces. Several human diseases have been genetically linked to Piezos, but the un ... Full text Cite

Stretch and poke stimulation for characterizing mechanically activated ion channels.

Book section · 2021 Quantitative functional characterization of mechanically activated ion channels is most commonly achieved by a combination of patch-clamp electrophysiology and stimulation by stretch (or pressure-clamp) and poke (or cell-indentation). A variety of stretch ... Full text Link to item Cite

High-Throughput Approaches to Studying Mechanisms of TRP Channel Activation

Book section · 2011 Transient receptor potential (TRP) channels are calcium-permeable nonselective cation channels with six transmembrane (TM) domains and a putative pore loop between TM5 and TM6. About 28 mammalian TRP channels have been identified so far, with different num ... Cite