Jorg Grandl

Journal article Elife · October 29, 2021 Featured Work Piezo1 is a mechanically activated ion channel involved in sensing forces in various cell types and tissues. Cryo-electron microscopy has revealed that the Piezo1 structure is bowl-shaped and capable of inducing membrane curvature via its extended footprin ... Full text Open Access Link to item Cite

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix.

Journal article Cell Rep · November 28, 2017 Featured Work Piezo proteins form mechanically activated ion channels that are responsible for our sense of light touch, proprioception, and vascular blood flow. Upon activation by mechanical stimuli, Piezo channels rapidly inactivate in a voltage-dependent manner throu ... Full text Link to item Cite

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.

Journal article Cell Rep · June 20, 2017 Featured Work Several cell types experience repetitive mechanical stimuli, including vein endothelial cells during pulsating blood flow, inner ear hair cells upon sound exposure, and skin cells and their innervating dorsal root ganglion (DRG) neurons when sweeping acros ... Full text Link to item Cite

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Journal article Neuron · April 19, 2017 Featured Work A gold standard for characterizing mechanically activated (MA) currents is via heterologous expression of candidate channels in naive cells. Two recent studies described MA channels using this paradigm. TMEM150c was proposed to be a component of an MA chan ... Full text Link to item Cite

Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

Journal article Trends Biochem Sci · January 2017 Featured Work In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular carriers of an excitatory mechanically activated current found in many cells. This discovery has opened the floodgates for studying a vast number of mechanotransduction ... Full text Link to item Cite

Localized force application reveals mechanically sensitive domains of Piezo1.

Journal article Nat Commun · October 3, 2016 Featured Work Piezos are mechanically activated ion channels that function as sensors of touch and pressure in various cell types. However, the precise mechanism and structures mediating mechanical activation and subsequent inactivation have not yet been identified. Her ... Full text Link to item Cite

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension.

Journal article Elife · December 8, 2015 Featured Work Piezo1 ion channels mediate the conversion of mechanical forces into electrical signals and are critical for responsiveness to touch in metazoans. The apparent mechanical sensitivity of Piezo1 varies substantially across cellular environments, stimulating ... Full text Link to item Cite

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

Journal article Proc Natl Acad Sci U S A · November 25, 2014 Featured Work Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical l ... Full text Open Access Link to item Cite

Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations.

Journal article PLoS One · 2013 Featured Work Thermosensation is mediated by ion channels that are highly temperature-sensitive. Several members of the family of transient receptor potential (TRP) ion channels are activated by cold or hot temperatures and have been shown to function as temperature sen ... Full text Link to item Cite

Piezo proteins are pore-forming subunits of mechanically activated channels.

Journal article Nature · February 19, 2012 Featured Work Mechanotransduction has an important role in physiology. Biological processes including sensing touch and sound waves require as-yet-unidentified cation channels that detect pressure. Mouse Piezo1 (MmPiezo1) and MmPiezo2 (also called Fam38a and Fam38b, res ... Full text Link to item Cite

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.

Journal article Nat Neurosci · June 2010 Featured Work TRPV1 is the founding and best-studied member of the family of temperature-activated transient receptor potential ion channels (thermoTRPs). Voltage, chemicals and heat allosterically gate TRPV1. Molecular determinants of TRPV1 activation by capsaicin, all ... Full text Link to item Cite

Pore region of TRPV3 ion channel is specifically required for heat activation.

Journal article Nat Neurosci · September 2008 Featured Work Ion channels can be activated (gated) by a variety of stimuli, including chemicals, voltage, mechanical force or temperature. Although molecular mechanisms of ion channel gating by chemical and voltage stimuli are understood in principal, the mechanisms of ... Full text Link to item Cite