Scholars@Duke
Christopher Bull Granger

Christopher Bull Granger

Fred Cobb, M.D. Distinguished Professor of Medicine
Medicine, Cardiology
christopher.granger@duke.edu
Duke Box 3409, Durham, NC 27710
300 West Morgan Street, Durham, NC 27701

Scholarly Works - Conferences

Regional differences in clinical outcomes in patients of asian race with atrial fibrillation randomized to direct oral anticoagulants vs warfarin: a patient-level meta-analyses from COMBINE AF

Conference European Heart Journal · November 5, 2025 AbstractBackgroundA previous report from the COMBINE AF database (A Collaboration Between Multiple Institutions to Better Inves ... Full text Cite

Validation of the DOAC Score among patients on vitamin K antagonists

Conference European Heart Journal · November 5, 2025 AbstractBackgroundThe DOAC Score stratifies bleeding risk in patients with atrial fibrillation (AF) taking direct oral anticoag ... Full text Cite

Efficacy and safety of direct oral anticoagulants in patients with device-detected atrial fibrillation with and without dose reduction criteria: a pooled analysis of ARTESiA and NOAH-AFNET 6

Conference European Heart Journal · November 5, 2025 AbstractBackgroundIn patients with device-detected atrial fibrillation (AF), direct oral anticoagulants (DOACs), as compared to ... Full text Cite

Cost-effectiveness of apixaban vs aspirin for the reduction of thrombo-embolism in high-risk patients with device-detected atrial fibrillation: insights from the ARTESiA trial

Conference European Heart Journal · November 5, 2025 AbstractBackgroundThe Apixaban for the Reduction of Thrombo-Embolism in Patients with Subclinical Atrial Fibrillation (ARTESiA) ... Full text Cite

Genetic traits associated with plasma atrial biomarker BMP10: GWAS and Mendelian randomization study on stroke and heart failure in patients with atrial fibrillation

Conference European Heart Journal · November 5, 2025 AbstractAimsBone morphogenetic protein 10 (BMP10) has emerged as a novel atrial specific biomarker. BMP10 is associated with in ... Full text Cite

Abstract Sun1301: Workplace-Driven CPR Training at Scale: Implementation of the HeartSafe Workplace Initiative in the RACE-CARS Trial

Conference Circulation · November 4, 2025 Background: Sudden cardiac arrest (SCA) is a leading cause of death in the U.S., yet bystander CPR rates remain low. Strategies are needed to expand CPR training to reach millions, par ... Full text Cite

Abstract 4346591: Cardiovascular Diagnoses Following Smartwatch Irregular Pulse Notifications: Insights from the Apple Heart Study

Conference Circulation · November 4, 2025 Background: Atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality, and early detection is important for stroke prevention. The Apple Heart Study (AHS) d ... Full text Cite

Abstract 4351507: Older, non-White, Female and Uninsured Patients With a STEMI Are More Likely to be Transported to a non-Cardiac Cath Lab Center by EMS

Conference Circulation · November 4, 2025 Background: For patients with ST segment elevation myocardial infarction (STEMI), rapid access to primary percutaneous coronary intervention (PPCI) is critical, and guidelines recommen ... Full text Cite

Abstract Sa504: Association between Dispatch-Performance and Outcomes after Out-of-Hospital Cardiac Arrest in North Carolina: A registry analysis

Conference Circulation · November 12, 2024 Introduction: Each year in the U.S., over 350,000 people experience out-of-hospital cardiac arrests (OHCA), with a survival rate of just 10%. Most do not receive bystander CPR before professional resc ... Full text Cite

Abstract Sa701: Sex disparities in receipt of bystander-initiated cardiopulmonary resuscitation and associated time measures

Conference Circulation · November 12, 2024 Introduction: Female sex is associated with lower rates of bystander cardiopulmonary resuscitation (B-CPR) in public. Telecommunicator CPR (T-CPR), or provision of CPR instructions when individuals ca ... Full text Cite

Abstract Sa1205: Understanding Barriers to Bystander Use of Automated External Defibrillators (AEDs) in Cardiac Arrest: A Cross-Sectional Survey in North Carolina

Conference Circulation · November 12, 2024 Introduction: Early defibrillation is a critical link in the chain of survival after out-of-hospital cardiac arrest. However, bystander defibrillation rates are extremely low (<2% in North Carolina ... Full text Cite

Abstract Su707: Sex Differences in Bystander Cardiopulmonary Resuscitation and Survival to Hospital Discharge for Public Out-of-Hospital Cardiac Arrests in North Carolina and Singapore

Conference Circulation · November 12, 2024 Introduction: Although it is known that women are less likely than men to receive bystander cardiopulmonary resuscitation (BCPR) in public, few studies have examined differences in receipt of BCPR and ... Full text Cite

Abstract 4141927: Risk of myocardial infarction in paroxysmal vs. non-paroxysmal atrial fibrillation: an individual patient-level data analysis of 71,466 patients from COMBINE AF

Conference Circulation · November 12, 2024 Background: Prior data suggest the MI risk may be higher with paroxysmal AF (PAF) vs. non-paroxysmal AF (non-PAF). Proposed mechanisms include tachycardia-induced oxidative stress (via LOX-1) with mic ... Full text Cite

Predictors and outcomes of intracranial hemorrhage in 58,000 patients with atrial fibrillation on oral anticoagulation: insights from COMBINE-AF

Conference European Heart Journal · October 28, 2024 AbstractBackgroundAmong anticoagulated patients with atrial fibrillation (AF), intracranial hemorrhage (ICH) is the leading cause of b ... Full text Cite

Extracranial systemic embolic events in patients with atrial fibrillation: an individual patient-level meta-analysis of 71 683 patients randomized to NOAC vs warfarin from the COMBINE-AF study

Conference European Heart Journal · October 28, 2024 AbstractBackgroundAtrial Fibrillation (AF) poses a significant risk for both ischemic stroke and systemic embolic events (SEE). While ... Full text Cite

Heart failure risk assessment using biomarkers in patients with atrial fibrillation: analysis of 32,041 patients from the COMBINE-AF study

Conference European Heart Journal · October 28, 2024 AbstractIntroductionHeart failure (HF) is one of the most common comorbidities in patients with AF, resulting in a clinical need for r ... Full text Cite

Clinical outcomes in &gt;10,000 Asian vs &gt;61,000 Non-Asian race patients with AF randomized to Warfarin vs DOACs: a patient-level meta-analyses from COMBINE AF

Conference European Heart Journal · October 28, 2024 AbstractBackgroundRandomized data comparing clinical outcomes of atrial fibrillation (AF) patients with Asian vs non-Asian races are l ... Full text Cite

Evaluation of the biomarker-based ABC-AF-bleeding risk score and clinically based bleeding scores in 31,605 patients with atrial fibrillation treated with oral anticoagulation

Conference European Heart Journal · October 28, 2024 AbstractBackgroundInternational guidelines recommend a systematic evaluation of bleeding risk in patients with atrial fibrillation (AF ... Full text Cite

Differences in risk profiles and clinical outcomes according to age in patients with high-risk myocardial infarction: insights from the PARADISE-MI trial

Conference European Heart Journal · October 28, 2024 AbstractIntroductionTemporal declines in rates of rehospitalization and death after acute myocardial infarction (MI) have not been uni ... Full text Cite

Association of contemporary hormonal contraception and the risk of arterial thrombosis

Conference European Heart Journal · October 28, 2024 AbstractBackgroundWhile contemporary hormonal contraception is effective in preventing unwanted pregnancies, its potential link to an ... Full text Cite

The majority of 30-days survivors return to work one-year after in-hospital cardiac arrest

Conference European Heart Journal · October 28, 2024 AbstractBackgroundSurviving in-hospital cardiac arrest poses a significant risk of anoxic brain damage, which can impede survivors’ ab ... Full text Cite

KARDIA-3 STUDY DESIGN: ZILEBESIRAN AS ADD-ON THERAPY IN PATIENTS WITH HIGH CARDIOVASCULAR RISK AND HYPERTENSION INADEQUATELY CONTROLLED BY STANDARD OF CARE ANTIHYPERTENSIVES

Conference Journal of Hypertension · May 2024 Objective:Zilebesiran is an investigational subcutaneous (SC) RNA interference therapeutic that targets synthesis of hepatic angiotensinogen, the most upstream precursor of the renin-angi ... Full text Cite

SURVIVAL AND FUNCTIONAL OUTCOMES AFTER IN-HOSPITAL CARDIAC ARREST ACCORDING TO TIME OF DAY

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · April 2, 2024 Link to item Cite

REMOTE FOLLOW-UP IN A HEART FAILURE PRAGMATIC TRIAL: INSIGHTS FROM THE CONNECT-HF

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · April 2, 2024 Link to item Cite

REMOTE FOLLOW-UP IN A HEART FAILURE PRAGMATIC TRIAL: INSIGHTS FROM THE CONNECT-HF

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2024 Cite

Abstract 232: Predicted One Third Improvement in Survival for Shockable Rhythms of a Proposed First Responder and Drone Automated External Defibrillator Delivery Program in North Carolina

Conference Circulation · November 7, 2023 Background: Drone-delivered AEDs can improve access to defibrillation for OHCA. If drone-delivered AEDs arrive at the OHCA before EMS, then the OHCA’s first recorded rhythm may differ from that record ... Full text Cite

Abstract 105: Rural-Urban Differences for Integrated First Responder and Drone Automated External Defibrillator Delivery in North Carolina

Conference Circulation · November 7, 2023 Background: Early defibrillation for out-of-hospital cardiac arrest (OHCA) can improve survival significantly, but timely access to AEDs remains a barrier especially in rural areas. We analyzed whethe ... Full text Cite

Abstract 11983: Biomarker Profile of Patients With Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction or Reduced Ejection Fraction: Insights From the ARISTOTLE Trial

Conference Circulation · November 7, 2023 Introduction: Heart failure with preserved ejection fraction (HFpEF) is a poorly understood entity with phenotypic differences to heart failure with reduced ejection fraction (HFrEF). To shed light on ... Full text Cite

Abstract 18200: Prognostic Importance of Serial NT-proBNP Measurements Following High-Risk Mi: The PARADISE-MI Trial

Conference Circulation · November 7, 2023 Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potent predictor of heart failure (HF) and death following myocardial infarction (MI). NT-proBNP levels change post MI. ... Full text Cite

Abstract 14399: Development of Heart Failure in High-Risk Post-Myocardial Infarction Patients: An Analysis of the Paradise-MI Trial

Conference Circulation · November 7, 2023 Objectives: The aims of this study were i) to examine the incidence, risk factors and subsequent mortality after high-risk acute myocardial infarction (AMI) and ii) compare the effects of sacubitril/v ... Full text Cite

Abstract 12701: Safety and Tolerability of Angiotensin Receptor Neprilysin Inhibitor Initiation in High-Risk Acute Myocardial Infarction Relative to Drug Initiation Setting: A Subgroup Analysis of the PARADISE-MI Trial

Conference Circulation · November 7, 2023 Background: The initiation of blood pressure lowering pharmacologic agents during an acute myocardial infarction (AMI) can be challenging. The PARADISE MI trial randomised AMI patients with LV dysfunc ... Full text Cite

Abstract 12724: High Health-Related Quality of Life Among Survivors of Out-of-Hospital Cardiac Arrest: A Nationwide Survey From 2001-2019

Conference Circulation · November 7, 2023 Background: Survival after out-of-hospital cardiac arrest has increased over the past two decades. However, little is known about the health-related quality of life of long-term survivors. < ... Full text Cite

Abstract TMP47: IMPROVING Time To Anti-Coagulation Reversal For Hemorrhagic Strokes

Conference Stroke · February 2023 Background: Oral anticoagulation (OAC) is a risk factor for intracerebral hemorrhage (ICH) which is an important source of disability and mortality. OAC-associated ICH (OAC-ICH) patients have worse ou ... Full text Cite

Abstract 13168: Benefits of Apixaban Over Warfarin are Preserved Independent of Warfarin Time in Therapeutic Range: Insights From the AUGUSTUS Trial

Conference Circulation · November 8, 2022 Introduction: In the AUGUSTUS trial, patients randomized to apixaban had lower rates of major or clinically relevant non-major (CRNM) bleeding, lower rates of death or hospitalization, and similar rat ... Full text Cite

Oral Presentation No. 53 Dose-related preprocedural patency of the infarct-related artery after zalunfiban (RUC-4) administration upon arrival at the catheterization laboratory in ST-elevation myocardial infarction: insights from the phase IIa study

Conference Cardiovascular Research · October 21, 2022 AbstractBackgroundThe importance of time to reperfusion after ST-elevation myocardial infarction (STEMI) is well established. Pre-hosp ... Full text Cite

Predictors of Atrial Fibrillation Development in Patients With Embolic Stroke of Undetermined Source: An Analysis of the RE-SPECT ESUS Trial.

Conference Circulation · November 30, 2021 BACKGROUND: A proportion of patients with embolic stroke of undetermined source have silent atrial fibrillation (AF) or develop AF after the initial evaluation. Better understanding of the risk for development of AF is critical to implement optimal monitor ... Full text Link to item Cite

Abstract P883: A Survey of Acute Stroke Blood Pressure Management Practices in the Southeastern US

Conference Stroke · March 2021 Background: IMPROVE Stroke Care is a regional implementation science study in the Southeastern US aimed at reducing acute stroke treatment times and improving outcomes through wide scale application o ... Full text Cite

Abstract 236: Gender Disparities in Bystander CPR and Defibrillation Persist in Black and Hispanic Neighborhoods in the US

Conference Circulation · November 17, 2020 Introduction: Bystander CPR (B-CPR) and defibrillation for sudden cardiac arrest (SCA) vary by gender with females being less likely to receive these interventions. Despite known differences by race a ... Full text Cite

SACUBITRIL-VALSARTAN FOLLOWING HOSPITAL DISCHARGE FOR HEART FAILURE

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial.

Conference Am J Med · December 2017 BACKGROUND: Cancer is associated with a prothrombotic state and increases the risk of thrombotic events in patients with atrial fibrillation. We described the clinical characteristics and outcomes and assessed the safety and efficacy of apixaban versus war ... Full text Link to item Cite

EXTERNAL VALIDATION OF THE BIOMARKER-BASED ABC-STROKE RISK SCORE FOR ATRIAL FIBRILLATION

Conference Journal of the American College of Cardiology · April 2016 Full text Cite

DIABETES MELLITUS AND CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC CORONARY HEART DISEASE

Conference Journal of the American College of Cardiology · April 2016 Full text Cite

EXTERNAL VALIDATION OF THE BIOMARKER-BASED ABC-BLEEDING RISK SCORE FOR ATRIAL FIBRILLATION

Conference Journal of the American College of Cardiology · April 2016 Full text Cite

Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.

Conference Circulation · August 25, 2015 BACKGROUND: Apixaban is approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. However, the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial inc ... Full text Link to item Cite

High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin.

Conference J Am Coll Cardiol · January 7, 2014 OBJECTIVES: The aim of this study was to evaluate the prognostic value of high-sensitivity troponin T (hs-TnT) in addition to clinical risk factors and the CHA2DS2VASc (congestive heart failure, hypertension, 75 years of age and older, diabetes mellitus, p ... Full text Link to item Cite

263 The Forgotten Lead: Does aVR ST-Deviation Add Insight Into STEMI Patients?

Conference Canadian Journal of Cardiology · September 2012 Full text Cite

Impact of spontaneous reperfusion in diabetics with acute myocardial infarction

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Sex-based differences in mortality following acute coronary syndromes

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Sex differences in clinical presentation and angiographic data in acute coronary syndromes

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Clopidogrel and CABG-related bleeding: Not as important as currently believed?

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Does NT-proBNP predict and explain poor outcomes in STEMI patients? Insights from ASSENT-4 PCI

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2007 Link to item Cite

Initial aspirin dose for the treatment of ST elevation myocardial infarction

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2007 Link to item Cite

ECG insights into the unexpected outcome of ASSENT-4 PCI

Conference EUROPEAN HEART JOURNAL · August 1, 2006 Link to item Cite

Deriving a safety index from the GRACE risk score

Conference EUROPEAN HEART JOURNAL · September 1, 2005 Link to item Cite

Systemic inflammatory response syndrome complicating acute ST-segment elevation myocardial infarction

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2005 Link to item Cite

Gene expression profile in circulating leukocytes identifies patients with coronary artery disease

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2005 Link to item Cite

Natriuretic peptide insights in acute myocardial infarction

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2005 Link to item Cite

Importance of CHARM in relation to other heart failure trials with ARBs

Conference EUROPEAN HEART JOURNAL SUPPLEMENTS · December 1, 2004 Link to item Cite

Thrombocytopenia Is More Common and Nadir Occurs Earlier with Unfractionated Heparin Than with Low Molecular Weight Heparin - Results from the Prospective Catch Registry.

Conference Blood · November 16, 2004 AbstractBackground : Thrombocytopenia in the patient on heparin can have various etiologies, including benign reversible causes and serious, potentially life-threatening ones, such as heparin induced thrombo ... Full text Cite

The acuteness score: New insights in predicting infarct size

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 3, 2004 Link to item Cite

1098-82 Dynamic modeling of ST elevation acute myocardial infarction: Insights from COMMA

Conference Journal of the American College of Cardiology · March 2004 Full text Cite

Evidence for early reperfusion and preservation of myocardium: A new salvage

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 19, 2003 Link to item Cite

Diabetes and ischemic heart disease.

Conference Am Heart J · November 1999 Full text Link to item Cite

Outcomes in GUSTO IIb in patients with ST-segment depression versus those with T-wave inversion

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1997 Link to item Cite

ATRIAL FUNCTION IN PHYSIOLOGICAL AND PATHOLOGICAL VENTRICULAR HYPERTROPHY

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1986 Link to item Cite