Grant Alan Robinson

Journal article Exp Neurol · February 2009 Featured Work A necessary prerequisite for recovery of motor function following a peripheral nerve injury is the correct choice by regenerating motor neurons to reinnervate the original distal nerve branch to denervated muscle. The present studies use the mouse femoral ... Full text Link to item Cite

Motor neuron regeneration accuracy: balancing trophic influences between pathways and end-organs.

Journal article Exp Neurol · May 2007 Featured Work The key to recovery of function following peripheral nerve lesions is guiding axons back to their original target end-organs. The parent femoral nerve splits into two comparable terminal pathways: one to the muscle and the other to the skin. Normally, moto ... Full text Link to item Cite

The specificity of motor neurone regeneration (preferential reinnervation).

Journal article Acta Physiol (Oxf) · February 2007 Featured Work The major determinant of functional recovery after lesions in the peripheral nervous system is the accurate regeneration of axons to their original target end-organs. Unfortunately, regenerating motor axons are often misrouted to sensory target end-organs, ... Full text Link to item Cite

Developmentally regulated changes in femoral nerve regeneration in the mouse and rat.

Journal article Exp Neurol · February 2006 Featured Work The attractive influence of muscle on regenerating motor neuron axons is well-known. Less is known, however, about the intrinsic abilities of different nerve pathways to support these axons prior to end-organ contact. The age at which a nerve injury is sus ... Full text Link to item Cite

Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons.

Journal article Exp Neurol · March 2005 Featured Work Previous studies using the femoral nerve model in both mice and rats have shown that regenerating motor axons prefer to reinnervate the terminal nerve branch to muscle versus a terminal nerve branch to skin, a process that has been termed preferential moto ... Full text Link to item Cite

Motor neurons can preferentially reinnervate cutaneous pathways.

Journal article Exp Neurol · December 2004 Featured Work Previous work in the rat femoral nerve has shown that regenerating motor neurons preferentially reinnervate a terminal nerve branch to muscle as opposed to skin. This process has been termed preferential motor reinnervation (PMR) and has been interpreted a ... Full text Link to item Cite

Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft.

Journal article Vision Res · October 2004 Featured Work Melanopsin is found in only approximately 2% of mouse retinal ganglion cells (RGCs), making these RGCs uniquely and directly photosensitive. Given that the majority of RGCs die after axotomy and that grafting of a peripheral nerve to the eye provides a per ... Full text Link to item Cite

Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture.

Journal article Muscle Nerve · August 2003 Featured Work Previous studies in rat femoral nerve demonstrated that regenerating motor axons preferentially reinnervate a nerve branch to muscle as opposed to skin, a process that has been termed preferential motor reinnervation (PMR). This process has not been previo ... Full text Link to item Cite

Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue.

Journal article J Neurosurg · August 2000 Featured Work OBJECT: The goal of this study was to examine whether the method of attachment of a peripheral nerve graft would have an effect on retinal ganglion cell (RGC) regeneration. METHODS: The number of adult rat RGCs with regrown axons in a peripheral nerve graf ... Full text Link to item Cite

Netrin-1 and peripheral nerve regeneration in the adult rat.

Journal article Exp Neurol · February 2000 Featured Work Axonal guidance during development of the nervous system is thought to be highly regulated through interactions of axons with attractive, repulsive, and trophic cues. Similar mechanisms regulate axonal regeneration after injury. The netrins have been shown ... Full text Link to item Cite

lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling.

Journal article Biotechniques · September 1998 Featured Work There is an increasing interest in being able to document simultaneous levels of multiple mRNAs from limited amounts of mammalian tissue. The combination of amplified antisense RNA (aRNA) and reverse Northern blot analysis is one technology that allows the ... Full text Link to item Cite

Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells.

Journal article Brain Res Mol Brain Res · September 5, 1996 Featured Work The expression of one member of the bZip superfamily of transcription factors, c-Jun, is known to be induced by axotomy in retinal ganglion cells (RGCs) and is associated with axonal regrowth. This study used immunohistochemistry combined with retrograde l ... Full text Link to item Cite

Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells.

Journal article Brain Res Mol Brain Res · May 1995 Featured Work Antibodies to c-Jun, JunD, JunB, c-Fos, FosB and Krox-24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft. First, expression in ga ... Full text Link to item Cite

Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat.

Journal article Brain Res Mol Brain Res · July 1994 Featured Work To determine if axotomy-induced immediate early gene (IEG) expression accompanies regenerative efforts in central nervous system (CNS) neurons, immunohistochemistry using antibodies to c-Jun, JunD, JunB, c-Fos, FosB and Krox-24 proteins was used to examine ... Full text Link to item Cite

Behavior of motor units in human biceps brachii during a submaximal fatiguing contraction.

Journal article J Appl Physiol (1985) · June 1994 Featured Work The activity of 50 single motor units was recorded in the biceps brachii muscle of human subjects while they performed submaximal isometric elbow flexion contractions that were sustained to induce fatigue. The purposes of this study were to examine the inf ... Full text Link to item Cite