Journal articleJ Am Acad Dermatol · August 2026
BACKGROUND: ItchyQuant is a validated patient-reported outcome measure rating itch. Assessment of subjective itch is important in clinical care to adequately understand disease burden. OBJECTIVE: To assess itch severity among patients seen at a high-volume ...
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Journal articleMusculoskelet Sci Pract · August 2026
BACKGROUND: Treatment mechanisms of force-based manipulation (manual therapies) aim to explain not just "whether" the treatment works but "why" and "how" a treatment works. To date, a majority of studies have failed to address whether treatment mechanisms ...
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Journal articleJ Heart Lung Transplant · July 15, 2026
BACKGROUND: Novel heart procurement and preservation strategies have altered the organ procurement landscape. Heart organ procurement services (HOPS) have emerged as integrated businesses to procure and transport donor organs. While HOPS may provide conven ...
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Journal articlePain Manag · July 2026
BACKGROUND: To date, very few studies have used mediation analysis to explore the reasons why people with chronic neck pain improve after physical therapy intervention involving manual therapy or exercise. OBJECTIVES: To evaluate which specific mechanisms ...
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Journal articleJ Racial Ethn Health Disparities · June 24, 2026
IMPORTANCE: Cutaneous melanoma accounts for 5% of new cancer diagnoses in the United States. Despite advancements in treatment of melanoma, marked racial, ethnic, and socioeconomic disparities persist. OBJECTIVE: To determine if there are racial and ethnic ...
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Journal articleClimacteric · June 2026
OBJECTIVE: Adhesive capsulitis (AC) is considered idiopathic, yet typically affects women aged 40-60 years. The purpose of this study was to determine whether hormone therapy is protective against AC in menopausal women. The study hypothesized that patient ...
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Journal articleLancet Reg Health Am · June 2026
BACKGROUND: Heart failure (HF) causes substantial morbidity and mortality, in part because evidence-based pharmacotherapies remain underused. Remote, asynchronous digital platforms may accelerate the initiation and titration of pharmacotherapies outside of ...
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Journal articleSpine Deform · May 7, 2026
PURPOSE: While opioids are commonly prescribed for postoperative pain management, their use is recommended with caution in pediatric populations. In adult populations, patient sex has been identified as a predictor for increased opioid use, and understandi ...
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Journal articleClin Infect Dis · May 5, 2026
BACKGROUND: Postoperative spinal implant infections (PSII) are a serious complication of instrumented spinal fusion. Although debridement with implant retention is standard for early infection, the optimal duration of antimicrobial therapy remains uncertai ...
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Journal articleBMC Pulm Med · April 25, 2026
BACKGROUND: Tracheobronchomalacia (TBM) is a condition characterized by excessive collapse of the trachea and mainstem bronchi, often resulting in chronic cough and dyspnea. Though associated with obesity and increasingly recognized as a contributor to une ...
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Journal articleSpine (Phila Pa 1976) · April 8, 2026
STUDY DESIGN: Prospective. OBJECTIVE: To evaluate the construct validity of PROMIS Positive Affect (PA), Life Satisfaction (LS), and Meaning & Purpose (MP) measures compared to the SRS-22 in AIS patients and determine whether these measures capture distinc ...
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Journal articleJ Natl Med Assoc · April 2026
BACKGROUND: Underrepresented racial and ethnic group (UREG) participation in heart failure (HF) clinical trials has not historically represented the disproportionate high burden in those communities. HF registries may include more UREGs based on broader in ...
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Journal articlePain Rep · April 2026
INTRODUCTION: High-impact chronic pain (HICP) is associated with impaired function, diminished quality of life, and greater healthcare utilization. Although total joint arthroplasty (TJA) is effective for osteoarthritis, up to 20% of patients report persis ...
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Journal articleSpine Deform · March 2026
INTRODUCTION: Prior to surgical intervention for adolescent idiopathic scoliosis (AIS), patients with mild-to-moderate deformity and skeletal growth remaining can be treated conservatively after referral to specialists. Healthcare access may influence scre ...
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Journal articleOsteoarthr Cartil Open · March 2026
OBJECTIVE: This study describes the 2-year self-reported joint function outcomes of patients enrolled in a US-based comprehensive hip and knee osteoarthritis management program (OAMP), and demographic characteristics associated with change in function. DES ...
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Journal articleJID Innov · March 2026
With the rising prevalence of endocrine conditions in the U.S., it is important to examine the relationship between diabetes mellitus and hidradenitis suppurativa (HS) severity. This retrospective, cross-sectional study evaluated whether diabetes status an ...
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Journal articleValue Health · February 2026
OBJECTIVES: Hip fractures represent a significant cost burden internationally, offering an area for improving value-based care. The objective of this study was to evaluate associations between hospital/regional-level characteristics and negotiated payer ra ...
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Journal articleAm Heart J · December 2025
BACKGROUND: Among patients with heart failure (HF), guideline-directed medical therapy (GDMT) remains underutilized. Remote digital interventions may facilitate rapid initiation and uptitration of GDMT; however, potential benefits have not been evaluated i ...
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Journal articleJMIR Res Protoc · November 17, 2025
BACKGROUND: Spine surgery is increasingly common in the United States, contributing substantially to spine-related health care costs. While many patients benefit, up to 25% experience chronic postsurgical pain, and the procedure is linked to high rates of ...
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Journal articleJID Innov · November 2025
Measures of clinical productivity may tilt financial incentives toward providing care to specific patient populations, reinforcing inequitable care. Race, sex, and age have been shown to influence differences in work relative value units (wRVUs) generated ...
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Journal articleArthrosc Sports Med Rehabil · October 2025
PURPOSE: To systematically review the literature evaluating whether incorporating ligament thickening and increased signal intensity alongside ligament discontinuity on magnetic resonance imaging (MRI) improves diagnostic accuracy for anterior talofibular ...
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Journal articleJB & JS open access · October 2025
BackgroundPatient portal (PP) usage enhances patient engagement, quality of care, and clinical outcomes. However, effective utilization requires digital literacy and internet access, resulting in disparities, particularly among older, non-White, u ...
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Journal articleThe Journal of thoracic and cardiovascular surgery · July 2025
BackgroundWe previously reported that concurrent tricuspid valve surgery (TVS) was not associated with a lower incidence of early right heart failure (RHF) in patients undergoing durable left ventricular assist device (LVAD) implantation. This fol ...
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Journal articleJ Knee Surg · July 2025
Varus-producing distal femoral osteotomy (DFO) is an established procedure to correct genu valgum in patients with osteoarthritis and gait abnormalities. DFO has also been proposed for the treatment of patellar instability in patients with valgus alignment ...
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Journal articleJIMD Rep · July 2025
Barth syndrome (BTHS) is a rare X-linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac transplantation c ...
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Journal articleArthroplast Today · June 2025
BACKGROUND: Patellofemoral arthroplasty (PFA) is an attractive option for patients who have isolated patellofemoral disease. This study aimed to assess the functional outcomes and revision rates of primary PFA with a third-generation implant with short- to ...
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Journal articleFoot Ankle Orthop · April 2025
BACKGROUND: Total ankle replacement (TAR) is an established treatment for end-stage ankle arthritis, offering pain relief and improved functionality. The Scandinavian Total Ankle Replacement (STAR) was first used in the United States in 1998 and although u ...
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Journal articleJ Shoulder Elbow Surg · March 2025
BACKGROUND: Regional anesthesia is a valuable component of multimodal pain control in total shoulder arthroplasty (TSA), and multiple interscalene block anesthetic options exist, including nonliposomal interscalene bupivacaine (NLIB) and liposomal intersca ...
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Journal articleJ Rural Health · March 2025
PURPOSE: To assess rural-urban and health professional shortage area (HPSA)-related influences on the characteristics of melanoma in North Carolina. METHODS: We conducted a single-center retrospective cohort study of patients living in North Carolina with ...
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Journal articleArch Dermatol Res · January 10, 2025
BACKGROUND: Psoriasiform dermatitis can be defined both clinically and histologically, but is not a traditionally recognized clinical or histologic diagnosis. OBJECTIVE: Analyze the final clinical diagnosis, demographics and clinical characteristics in pat ...
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Journal articleAm Heart J · January 2025
BACKGROUND: Given the increasing interest in dietary interventions to improve cardiovascular health, this trial assessed the impact of fortified eggs (FE) versus nonegg supplemented diet and time-restricted eating (TRE) versus usual care diet on cardiovasc ...
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Journal articleFront Physiol · 2025
INTRODUCTION: Abdominal compression is recommended to manage orthostatic intolerance in dysautonomia, but the hemodynamic effects of different compression parameters remain poorly understood. This study investigated how surface area and pressure magnitude ...
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Journal articleChest · December 2024
BACKGROUND: The hemoglobin value to trigger RBC transfusion for patients receiving venovenous extracorporeal membrane oxygenation (ECMO) is controversial. Previous guidelines recommended transfusing to a normal hemoglobin level, but recent studies suggest ...
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Journal articleOsteoarthr Cartil Open · December 2024
OBJECTIVE: Osteoarthritis management programs (OAMPs) have become a more common way to deliver patient-centered care. However, there is limited information on real-world use of these programs to guide implementation, payment policy, accessibility, and scal ...
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Journal articleHand (N Y) · November 2024
BACKGROUND: The incidence of operative treatment of distal radius fractures (DRFs) has increased recently, but the optimal timing for surgical fixation remains unclear. We hypothesized that: (1) an increase in time to fixation of intra-articular DRFs would ...
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Journal articleJHLT Open · November 2024
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) and additional cardiac or pulmonary comorbidities have a poor prognosis and are frequently excluded from clinical trials. The purpose of this study was to evaluate outcomes of patients with pu ...
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Journal articleClin Orthop Relat Res · October 1, 2024
BACKGROUND: Treatment with a static or an articulating antibiotic-containing spacer is a common strategy for treating periprosthetic joint infection (PJI), yet many patients have persistent infections after spacer treatment. Although previous studies have ...
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Journal articleDiabetes Obes Metab · August 2024
AIM: To investigate if patients with diabetes taking metformin have better outcomes versus those not taking metformin following an emergency room visit for influenza. METHODS: Using electronic medical records, we performed a retrospective chart review of a ...
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Journal articleAnn Am Thorac Soc · August 2024
Rationale: Data on risk factors for chronic hypoxemia in low- and middle-income countries are lacking. Objectives: We aimed to quantify the association between potential risk factors and chronic hypoxemia among adults hospitalized in Kenya. Methods: A hosp ...
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Journal articleJACC Adv · August 2024
BACKGROUND: The cardiopulmonary exercise test (CPET) is considered a gold standard in assessing cardiorespiratory fitness (CRF) but has limited accessibility due to competency requirements and cost. Incorporating portable sensor devices into a simple bedsi ...
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Journal articleJ Orthop Trauma · July 1, 2024
OBJECTIVES: Racial disparities in healthcare outcomes exist, including in orthopaedic trauma care. The aim of this study was to determine the impact of race, social deprivation, and payor status on 90-day emergency department (ED) revisits among orthopaedi ...
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Journal articleEur J Heart Fail · June 2024
AIMS: The PARACOR-19 randomized controlled trial (RCT) was designed to examine the effects of sacubitril/valsartan on markers of cardiac injury, inflammation, structure, and function among patients who have recovered from acute coronavirus disease 2019 (CO ...
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Journal articleOpen Forum Infect Dis · June 2024
BACKGROUND: The optimal duration and choice of antibiotic for fracture-related infection (FRI) is not well defined. This study aimed to determine whether antibiotic duration (≤6 vs >6 weeks) is associated with infection- and surgery-free survival. The seco ...
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Journal articleJ Thorac Cardiovasc Surg · May 2024
OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ...
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Journal articleJ Am Acad Orthop Surg · May 1, 2024
INTRODUCTION: Health inequities remain a notable barrier for pediatric patients, especially in conditions such as adolescent idiopathic scoliosis (AIS), where the efficacy of nonsurgical treatment is dependent on early diagnosis and referral to a specialis ...
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Journal articleJ Allergy Clin Immunol Glob · May 2024
BACKGROUND: Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. OBJECTIVE: We sought to determine the burden (prevalence, mortality, and activity and work impairment) of severe asthm ...
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Journal articleJ ISAKOS · April 2024
OBJECTIVES: The purpose of this study was to utilize Patient-Reported Outcomes Measurement Information System (PROMIS) sleep scores to determine the prevalence of sleep dysfunction and its association with other PROMIS scores in patients with rotator cuff ...
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Journal articleCirc Cardiovasc Qual Outcomes · April 2024
BACKGROUND: Drone-delivered automated external defibrillators (AEDs) hold promises in the treatment of out-of-hospital cardiac arrest. Our objective was to estimate the time needed to perform resuscitation with a drone-delivered AED and to measure cardiopu ...
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Journal articleAm J Sports Med · February 2024
BACKGROUND: Combined injury of the anterior cruciate ligament (ACL) and the medial collateral ligament (MCL) is a common injury pattern and accounts for 20% of all ligamentous knee injuries. Despite advancements in surgical technique, there is no up-to-dat ...
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Journal articleFoot Ankle Surg · January 2024
BACKGROUND: The literature demonstrating positive outcomes after total ankle arthroplasty (TAA) is mounting. However, the long-term outcomes of TAA (≥ 10 years) remain minimally reported. The purpose of this systematic review and meta-analysis was to evalu ...
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Journal articleDermatitis · 2024
Background: Supplemental patch testing is an adjunct to standard patch test screening series. Objective: To determine the demographics, characteristics, frequency, relevance, and interpretation of patch test reactions for supplemental patch testing. Method ...
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Journal articleAcad Pediatr · 2024
OBJECTIVE: Despite the high prevalence of obesity and the clustering of risk by neighborhood, few studies have examined characteristics which promote healthy child weight in neighborhoods with high obesity risk. We aimed to identify protective factors for ...
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Journal articleSpine (Phila Pa 1976) · November 1, 2023
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: This study identifies potential disparities in telemedicine utilization in the wake of the COVID-19 pandemic and its aftermath in patients receiving spine surgery. SUMMARY OF BACKGROUND DATA: COVID-19 le ...
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Journal articleAm J Cardiovasc Drugs · November 2023
BACKGROUND: There is evidence to suggest that colchicine reduces the risk of recurrent atrial fibrillation (AF) after catheter ablation; however, the tolerability and safety of colchicine in routine practice is unknown. METHODS: Patients undergoing cathete ...
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Journal articleClin Spine Surg · October 1, 2023
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To examine patient portal use among the surgical spine patient population across different sociodemographic groups and assess the impact of patient portal use on clinical outcomes. SUMMARY OF BACKGROUND ...
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Journal articleClin Transplant · October 2023
INTRODUCTION: Heart transplant (HT) recipients with prior exposure to cytomegalovirus (CMV R+) are considered intermediate risk for CMV-related complications. Consensus guidelines allow for either universal prophylaxis (UP) or preemptive therapy (PET) (ser ...
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Journal articleBMJ Open · September 18, 2023
OBJECTIVE: Global medical oxygen security is limited by knowledge gaps in hypoxaemia burden and oxygen access in low-income and middle-income countries. We examined the prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya ...
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Journal articleCardiol Young · September 2023
Sudden cardiac arrest is an uncommon event with high morbidity and mortality. There are improved outcomes with early access to an automated external defibrillator and cardiopulmonary resuscitation. We assessed the availability of automated external defibri ...
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Journal articleJ Pediatr Orthop · September 1, 2023
BACKGROUND: Femoral shaft fractures are common injuries in children 2 to 7 years of age, with treatments ranging from casting to flexible intramedullary nails (FIN). Each treatment has unique attributes and outcomes are overall similar. Given equivalent ou ...
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Journal articleJ Intensive Care · September 1, 2023
The respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal membrane oxygenation (ECMO), but its performance in patients with Coronavirus Disease 2019 (COVID-19) acute respiratory distress synd ...
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Journal articleEnviron Res · August 1, 2023
Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ...
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Journal articleCrit Care Explor · August 2023
BACKGROUND: Carbon monoxide (CO) is an endogenous signaling molecule that activates cytoprotective programs implicated in the resolution of acute respiratory distress syndrome (ARDS) and survival of critical illness. Because CO levels can be measured in bl ...
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Journal articleJ Am Heart Assoc · July 18, 2023
Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circul ...
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Journal articleJAMA Netw Open · July 3, 2023
IMPORTANCE: Tailored treatments for low back pain (LBP) based on stratifying risk for poor prognosis have emerged as a promising approach to improve quality of care, but they have not been validated in trials at the level of individual randomization in US ...
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Journal articleClin Cardiol · July 2023
BACKGROUND: Racial disparities in health care are well established, with Black patients frequently experiencing the most significant consequences of this inequality. Acute pulmonary embolism (PE) is increasing in incidence and an important cause of morbidi ...
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Journal articleJ Pediatr · June 2023
OBJECTIVES: To use growth data from electronic health records to describe and model infant growth (weight velocity and peak body mass index [pBMI]) characteristics. STUDY DESIGN: We extracted data from all children born at ≥34 weeks of gestation within one ...
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Journal articleJAMA Netw Open · June 1, 2023
IMPORTANCE: Racial disparities in lung cancer screening (LCS) are often ascribed to barriers such as cost, insurance status, access to care, and transportation. Because these barriers are minimized within the Veterans Affairs system, there is a question of ...
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Journal articleJ Shoulder Elbow Surg · May 2023
BACKGROUND: Recent work has shown inpatient length of stay (LOS) following shoulder arthroplasty to hold the second strongest association with overall cost (after implant cost itself). In particular, a preoperative understanding for the patients at risk of ...
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Journal articleJ Arthroplasty · May 2023
BACKGROUND: As value-based reimbursement models mature, understanding the potential trade-off between inpatient lengths of stay and complications or need for costly postacute care becomes more pressing. Understanding and predicting a patient's expected bas ...
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Journal articleCureus · May 2023
BACKGROUND: Vestibular dysfunction is common following sports-related concussions (SRC). Within the current practice, it is theorized that patients with vestibular dysfunction as sequelae of sports-related concussion have a prolonged recovery time compared ...
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Journal articleAnn Thorac Surg · April 2023
BACKGROUND: Aspiration has been associated with graft dysfunction after lung transplantation, leading some to advocate for selective use of fundoplication despite minimal data supporting this practice. METHODS: We performed a multicenter retrospective stud ...
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Journal articleOrthop J Sports Med · April 2023
BACKGROUND: Psychological distress after orthopaedic surgery can lead to worse outcomes, including higher levels of disability and pain and lower quality of life. The 10-item Optimal Screening for Prediction for Referral and Outcome-Yellow Flag (OSPRO-YF) ...
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Journal articleJID Innov · March 2023
Patients with Parkinson disease (PD) are at high risk for developing melanoma, although current literature lacks details on the associated clinicopathologic characteristics. Our retrospective case-control study aimed to guide skin cancer surveillance recom ...
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Journal articleObes Pillars · March 2023
BACKGROUND: Healthy lifestyle behaviors that can prevent adverse health outcomes, including obesity, are formed in early childhood. This study describes feeding, television, and sleep behaviors among one-year-old infants and examines differences by sociode ...
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Journal articleDermatol Ther (Heidelb) · March 2023
INTRODUCTION: Limited data exist regarding demographic-specific teledermatology (TD) utilization during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to determine TD utilization trends during the pandemic. METHODS: A retrospective coho ...
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Journal articleJ Antimicrob Chemother · February 1, 2023
OBJECTIVES: To characterize the incidence of and risk factors for a detectable drug level (DDL) in patients that received inhaled aminoglycoside therapy. METHODS: This retrospective, single-centre study included adult patients who received at least one dos ...
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Journal articleJ Card Fail · January 2023
BACKGROUND: Primary graft dysfunction (PGD), the leading cause of early mortality after heart transplantation, is more common following donation after circulatory death (DCD) than donation after brain death (DBD). We conducted a single-center, retrospectiv ...
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Journal articleAm J Cardiol · January 1, 2023
Guidelines recommend aggressive low-density lipoprotein cholesterol (LDL-C) lowering in patients with atherosclerotic cardiovascular disease (ASCVD). However, the recommended threshold of LDL-C ≤70 mg/dL is often not achieved. We used data from the Duke Un ...
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Journal articleHeart Rhythm O2 · December 2022
BACKGROUND: Pulmonary vein (PV) isolation using radiofrequency ablation (RFA) to treat atrial fibrillation (AF) requires delivery of contiguous transmural lesions at the PV antra while avoiding injury to the esophagus. Continuous 2-dimensional phased-array ...
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Journal articleJ Card Fail · November 2022
BACKGROUND: Mobile health (mHealth) platforms can affect health behaviors but have not been rigorously tested in randomized trials. OBJECTIVES: We sought to evaluate the effectiveness of a pragmatic mHealth intervention in patients with heart failure (HF) ...
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Journal articleJAMA Dermatol · October 1, 2022
IMPORTANCE: Patient-submitted images vary considerably in quality and usefulness. Studies that characterize patient-submitted images in a real-life setting are lacking. OBJECTIVE: To evaluate the quality and perceived usefulness of patient-submitted images ...
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Journal articleJ Am Acad Orthop Surg · October 1, 2022
INTRODUCTION: Recent advances in preoperative 3D templating software allow surgeons to plan implant size and position for stemless total shoulder arthroplasty (TSA). Whether these preoperative plans accurately reflect intraoperative decisions is yet unknow ...
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Journal articlePLoS Med · October 2022
BACKGROUND: Children with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention. Chemoprevention regimens vary between countries, and the comparative efficacy of prevention regimens is ...
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Journal articleBr J Dermatol · September 2022
In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ...
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Journal articleJ Arthroplasty · July 2022
BACKGROUND: The materials and techniques for both primary and revision total hip arthroplasty (THA) have changed over time. This study evaluated if the indications for revision THA, rates of components utilized (femoral or acetabulum, both, or head/liner e ...
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Journal articleArthrosc Sports Med Rehabil · April 2022
PURPOSE: The purpose of this study was to identify an association between Patient-Reported Outcomes Measurement Information System (PROMIS) sleep scores and other PROMIS domains in patients with femoroacetabular impingement syndrome (FAIS). METHODS: Patien ...
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Journal articleJ Shoulder Elbow Surg · February 2022
BACKGROUND: The transition from inpatient to outpatient shoulder arthroplasty critically depends on appropriate patient selection, both to ensure safety and to counsel patients preoperatively regarding individualized risk. Cost and patient demand for same- ...
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Journal articleFoot Ankle Int · January 2022
BACKGROUND: Navicular stress fractures are becoming increasingly more common. There is no universal consensus on treatment. We provide an algorithm that we feel will be useful in determining treatment. METHODS: A retrospective study was performed on all pa ...
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Journal articleDermatitis · January 2022
BACKGROUND: Shoe contact allergy can be difficult to diagnose and manage. OBJECTIVE: The aim of the study was to characterize demographics, clinical characteristics, patch test results, and occupational data for the North American Contact Dermatitis Group ...
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Journal articleAcad Pediatr · 2022
OBJECTIVE: To examine racial and ethnic differences in maternal social support in infancy and the relationship between social support and mother-infant health behaviors. METHODS: Secondary analysis of baseline data from a multisite obesity prevention trial ...
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Journal articleAcad Pediatr · 2022
OBJECTIVES: We evaluated the prevalence of high weight status in children ages 0 to 24 months (m) using data from electronic health records (EHR) and NHANES. We also examined relationships between weight status during infancy and obesity at 24 months of ag ...
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Journal articleCrit Care Explor · December 2021
UNLABELLED: We assessed the effect of implementing a protocol-directed strategy to determine when patients can be liberated from venovenous extracorporeal membrane oxygenation on extracorporeal membrane oxygenation duration, time to initiation of first swe ...
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Journal articleFoot Ankle Spec · October 2021
Background. Ankle arthritis is a major cause of disability. Orthopaedic literature suggests improvement in health-related quality of life (HRQOL) after total ankle arthroplasty (TAA). This has not been compared with improvements observed in successful orth ...
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Journal articleJ Orthop Res · September 2021
Posttraumatic arthritis (PTA) occurs commonly after articular fracture and may arise, in part, from joint surface incongruity after injury. MRL/MpJ (MRL) "super-healer" mice are protected from PTA compared to C57BL/6 (B6) mice following articular fracture. ...
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Journal articleJ Card Fail · September 2021
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence with a 50% mortality rate within 3 years of diagnosis, but lacking effective evidence-based therapies. Specific echocardiographic markers are not typical ...
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Journal articleJ Appl Lab Med · September 1, 2021
BACKGROUND: Two previous reports from the same group concluded that the analytical reliability of Instrumentation Laboratory GEM4000 analyzers (GEM4K) deteriorated during a 24-hour period, based on results between samples from the same patient but collecte ...
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Journal articleJAAD Int · September 2021
BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ...
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Journal articleEur J Orthop Surg Traumatol · August 2021
INTRODUCTION: Heterotopic ossification (HO) is a well-known sequela after an elbow injury and is widely studied given the associated morbidity. The anatomic location of HO development for specific elbow injuries has not been reported. The purpose of this s ...
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Journal articleAnn Surg · August 1, 2021
OBJECTIVE: The aim of this study was to assess the outcomes of tracheostomy in patients with COVID-19 respiratory failure. SUMMARY BACKGROUND DATA: Tracheostomy has an essential role in managing COVID-19 patients with respiratory failure who require prolon ...
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Journal articleOrthop J Sports Med · August 2021
BACKGROUND: Graft tears and contralateral anterior cruciate ligament (ACL) tears are common in pediatric athletes after ACL reconstruction. Use of objective return-to-sports (RTS) criteria, in particular physical performance tests (PPTs), is believed to re ...
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Journal articleBMJ Open Respir Res · July 2021
OBJECTIVE: For the diagnosis of COVID-19, the yield of nasopharyngeal (NP) swabs is unclear, and bronchoalveolar lavage (BAL) is obtained to confirm the diagnosis. We assessed the utilisation of bronchoscopy for COVID-19 diagnosis in a multicenter study an ...
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Journal articleAm J Clin Pathol · May 18, 2021
OBJECTIVES: The aim of this multisite quality improvement study was to evaluate patients' experiences with the patient-centered pathology (PCP) consultation program and to determine whether PCP enhanced their care experience. METHODS: Patients were invited ...
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Journal articleEur Heart J Acute Cardiovasc Care · May 11, 2021
BACKGROUND: Risk stratification and management of hemodynamically stable pulmonary embolism remains challenging. Professional societies have published stratification schemes, but little is known about the management of patients with intermediate risk pulmo ...
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Journal articleHealth Qual Life Outcomes · May 1, 2021
BACKGROUND: Patients' psychological health may influence recovery and functional outcomes after total knee arthroplasty (TKA). Pain catastrophizing, known to be associated with poor function following TKA, encompasses rumination, magnification, and helples ...
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Journal articleJ Am Acad Dermatol · April 2021
BACKGROUND: Preservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited. OBJECTIVE: To evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and tre ...
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Journal articleJACC Heart Fail · April 2021
OBJECTIVES: The authors estimated changes of stressed blood volume (SBV) induced by splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart failure with reduced ejection fraction (HFrEF). BACKGROUND: The splanchnic vascular c ...
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Journal articleVirchows Arch · March 2021
The diagnosis of invasive adenocarcinoma of the gallbladder can sometimes be challenging. The presence of true desmoplastic reaction facilitates the diagnosis of invasion. However, desmoplasia-like changes can be observed in benign gallbladder conditions, ...
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Journal articleJ Hand Surg Am · March 2021
PURPOSE: Attending surgeons must participate in critical and key portions of procedures and otherwise be immediately available. However, surgeon-defined standards of the critical and key portions of surgery have been questioned, potentially affecting train ...
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Journal articleJ Cardiovasc Comput Tomogr · 2021
BACKGROUND: Left ventricular assist devices (LVAD) are increasingly used for durable mechanical circulatory support in advanced heart failure. While LVAD therapy provides substantial improvement in mortality and quality of life, long-term therapy confers i ...
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Journal articleDermatitis · January 2021
IMPORTANCE: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations. OBJECTIVE: This study aimed to determine the CR rates for F/BR allergens. DESIGN: A retrospecti ...
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Journal articleOrthop J Sports Med · January 2021
BACKGROUND: Return to sport (RTS) after anterior cruciate ligament (ACL) reconstruction in children is associated with a much higher risk (∼30%) of subsequent ACL injury than in adults. Most RTS testing protocols use a limb symmetry index (LSI) ≥90% on phy ...
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Journal articleSpine Deform · December 2020
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To investigate radiographic sagittal and spinopelvic parameters of patients with adolescent idiopathic scoliosis (AIS) treated with bracing and assess differences among those treated successfully and un ...
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Journal articleEur Heart J Acute Cardiovasc Care · November 27, 2020
BACKGROUND: Risk stratification and management of hemodynamically stable pulmonary embolism remains challenging. Professional societies have published stratification schemes, but little is known about the management of patients with intermediate risk pulmo ...
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Journal articleJACC Heart Fail · September 2020
OBJECTIVES: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF. BACKGROUND: Chronic heart failure (HF) is characterized by limited exercise capacity driven i ...
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Journal articleHeart Rhythm O2 · August 2020
BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. OBJECTIVE: The purpose of this study was to compa ...
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Journal articleFoot Ankle Int · August 2020
BACKGROUND: Characteristics of responders, or those who achieve a clinical improvement above the level of a minimal clinically important difference, have not been defined for total ankle arthroplasty (TAA). The purpose of this study was to determine patien ...
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Journal articleSpine (Phila Pa 1976) · June 15, 2020
STUDY DESIGN: Retrospective review. OBJECTIVE: To determine if adjuvant radiation therapy (RT) improves overall survival (OS) following surgical resection of chordomas. SUMMARY OF BACKGROUND DATA: The role of RT for the treatment of chordomas remains incom ...
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Journal articleJ Am Acad Dermatol · May 2020
OBJECTIVE: To provide a formal statistical comparison of the efficacy of melanoma detection among different clinical settings. METHODS: A systematic review and meta-analysis of all relevant observational studies on number needed to treat (NNT) in relation ...
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Journal articleJournal of cardiovascular translational research · April 2020
We evaluated the heterogeneity of outcomes among heart failure patients with ventricular recovery. The BEST trial studied patients with left ventricular ejection fraction (LVEF) ≤ 35%. Serial LVEF assessment was performed at baseline, 3 months, and 12 mont ...
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Journal articleAm J Surg Pathol · March 2020
We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19 ...
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Journal articleBMJ Open Respir Res · February 2020
RATIONALE: The relationship between clinical and biomarker characteristics of asthma and its severity in Africa is not well known. METHODS: Using the Expert Panel Report 3, we assessed for asthma severity and its relationship with key phenotypic characteri ...
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Journal articleJ Bone Joint Surg Am · January 15, 2020
BACKGROUND: Financial burden for patients, providers, and payers can reduce access to physical therapy (PT) after total knee arthroplasty (TKA). The purpose of the present study was to examine the effect of a virtual PT program on health-care costs and cli ...
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Journal articlePlatelets · 2020
Platelets are central to thrombosis. However, it is unknown whether platelets slip at vascular or device surfaces. The presence of platelet slip at a surface would interrupt physical contact between the platelet and that surface, and therefore diminish adh ...
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Journal articleDermatitis · 2020
BACKGROUND: Patch testing is the criterion standard for diagnosis and management of allergic contact dermatitis. Limitations on the number of allergens tested can negatively impact patient care. OBJECTIVE: This study reports clinical practice patterns of A ...
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Journal articleCutis · January 2020
Flipped and traditional classroom models were compared in the Duke University Medical Center (Durham, North Carolina) dermatology residency program for the 2014-2015 academic year. The residents participated in 12 lectures-6 traditional and 6 flipped-that ...
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Journal articleDermatitis · 2020
BACKGROUND: Contact dermatitis is a common disease that is associated with impaired quality of life. OBJECTIVE: We examined the effect of travel distance and other socioeconomic factors on duration of dermatitis before presentation at the Duke Contact Derm ...
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Journal articleJ Am Soc Cytopathol · 2020
INTRODUCTION: Immune checkpoint pathway markers induce immune tolerance to non-small cell lung cancer (NSCLC). Therapeutic antibodies targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have demonstrated efficacy in ...
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Journal articleJ Electrocardiol · 2020
AIM: To evaluate the interaction between sex and rate corrected QT interval (QTc) duration in normal subjects after drug-induced QT prolongation and in LQTS patients. METHODS: Semi-automated measurements were performed on 875 digital ECGs (200 normal subje ...
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Journal articlePacing Clin Electrophysiol · November 2019
BACKGROUND: Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence af ...
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Journal articleAm Heart J · October 2019
BACKGROUND: Although the high-risk acute pulmonary embolism (PE) population has been described, little is known about the contemporary inpatient experience and practice patterns of the PE population as a whole. METHODS: All patients with a diagnosis of acu ...
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Journal articleBone Joint J · September 2019
AIMS: Antifibrinolytic agents, including tranexamic acid (TXA) and epsilon-aminocaproic acid (EACA), have been shown to be safe and effective for decreasing perioperative blood loss and transfusion following total hip arthroplasty (THA) and total knee arth ...
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Journal articleJ Arthroplasty · July 2019
BACKGROUND: Routine laboratory studies are generally obtained following total knee arthroplasty (TKA), and often continued daily until discharge. This study aims to investigate the utility and cost-effectiveness of complete blood count (CBC) tests followin ...
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Journal articleJAMA Dermatol · July 1, 2019
IMPORTANCE: Cutaneous chronic graft-vs-host disease (cGVHD) is common after allogeneic hematopoietic stem cell transplant and is often associated with poor patient outcomes. A reliable and practical method for assessing disease severity and response to the ...
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Journal articleClin Orthop Relat Res · July 2019
BACKGROUND: The generalizability of data derived from patient-reported outcome measures (PROMs) depends largely on the proportion of the relevant population that completes PROM surveys. However, PROM survey responses remain low, despite efforts to increase ...
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Journal articleKnee · June 2019
BACKGROUND: There is a growing interest in avoiding discharging patients to rehab to maximize outcome and minimize complications after total knee arthroplasty (TKA). In addition, use of postoperative pain pathways that minimize opioid use is critical amids ...
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Journal articleJAMA Dermatol · June 1, 2019
This retrospective study evaluated 11 patients who underwent cardiac implant patch testing to assess the frequency of allergic reaction. ...
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Journal articleJ Am Acad Orthop Surg · May 1, 2019
INTRODUCTION: Periprosthetic joint infection (PJI) is a devastating complication of hip and knee arthroplasties. Surgical cultures are essential for the diagnosis and treatment of PJI. Yet, the ideal culture duration remains unclear. This study compares cu ...
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Journal articleAm Heart J · May 2019
Heart failure (HF) and diabetes mellitus (DM) are major public health issues that place significant burden on patients and health care systems. Patients with both HF and DM are at higher risk of adverse cardiovascular and HF outcomes than those with either ...
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Journal articleShoulder Elbow · May 2019
BACKGROUND: The modified Goutallier classification system describes the fatty infiltration of rotator cuff musculature (RCM) seen on magnetic resonance imaging (MRI) to assist with surgical decision-making for patients with rotator cuff tears (RCT). We des ...
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Journal articleDiagn Cytopathol · April 2019
BACKGROUND: Diagnostic vitrectomy with flow cytometry immunophenotyping (FCI) is being increasingly used as part of screening for diagnostically challenging cases. We aim to evaluate the utility of combined cytopathology and FCI in diagnostic pars plana vi ...
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Journal articleFoot Ankle Int · March 2019
BACKGROUND:: Total ankle arthroplasty (TAA) is increasingly being recognized as an effective surgical option for end-stage ankle arthritis. Associated hindfoot arthrodesis procedures are at times needed to correct malalignment or to address adjacent joint ...
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Journal articleAm J Sports Med · March 2019
BACKGROUND: Legacy hip outcome measures may be burdensome to patients and sometimes yield floor or ceiling effects. Patient-Reported Outcomes Measurement Information System (PROMIS) computer adaptive tests (CATs) allow for low-burden data capture and limit ...
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Journal articleOrthopedics · March 1, 2019
Current antifibrinolytics have decreased perioperative blood loss; however, some patients still require transfusions postoperatively. The authors sought to determine the risk factors associated with postoperative transfusions and to establish a "cutoff" pr ...
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Journal articleJ Bone Joint Surg Am · February 20, 2019
BACKGROUND: Elements of competency-based training are being incorporated into surgical training. The primary objective of this study was to determine how the orientation of the arthroscope and the instruments relative to the standing position of the surgeo ...
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Journal articleUltrastruct Pathol · 2019
Asbestos is well-recognized as the cause of a variety of disorders of the respiratory tract, including neoplastic as well as non-neoplastic conditions. Fiber dimensions and biopersistence are important determinants of the pathologic response, and analytica ...
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Journal articleAdv Orthop · 2019
BACKGROUND: Recent evidence suggests benefit to receiving physical therapy (PT) the same day as total joint arthroplasty (TJA), but relatively little is known about barriers to providing PT in this constrained time period. We address the following question ...
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Journal articleJ Electrocardiol · 2019
The electrocardiogram is often used as an efficacy endpoint for comparing new drugs or as an indicator for cardiovascular safety in both studies of arrhythmic and non-arrhythmic novel drugs. The FDA ECG Warehouse data are owned by the submitting entities, ...
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Journal articleSeminars in Arthroplasty Jses · December 1, 2018
Background: Acetabular component malpositioning has been associated with major complications including dislocation, edge-loading, stripe wear and squeaking. Anteversion is determined by pelvic orientation; flexion of the pelvis increases and extension decr ...
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Journal articleInt J Cardiol · November 15, 2018
BACKGROUND: The presence of reperfusion ventricular arrhythmias (VA) has been shown to correlate with larger infarct size (IS). However it is unclear whether the initial area at risk (AAR), also a determining factor for IS, is responsible for this correlat ...
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Journal articleOrthopedics · November 1, 2018
Malnutrition is not uncommon in arthroplasty patients, and hypoalbuminemia has been shown to be predictive of postoperative complications. The authors sought to compare albumin concentration with a global assessment of physical health, the American Society ...
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Journal articleJ Arthroplasty · October 2018
BACKGROUND: Routine laboratory studies are often obtained following total hip arthroplasty (THA). Moreover, laboratory studies are often continued daily until the patient is discharged regardless of medical management. The purpose of this study was to inve ...
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Journal articleHip Int · September 2018
INTRODUCTION: Annually in the USA, 113,000 patients with refractory obesity undergo bariatric surgery (BS), and a subset does so in order to lower body mass index to become a more desirable total hip arthroplasty (THA) candidate. This study aims to evaluat ...
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Journal articleJ Arthroplasty · September 2018
BACKGROUND: The shift toward value-based bundled payment models in total joint arthroplasty highlights the need for identification of modifiable risk factors for increased spending as well as opportunities to mitigate perioperative treatment of chronic dis ...
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Journal articleJ Arthroplasty · September 2018
INTRODUCTION: Routine laboratory studies are often obtained daily after total joint arthroplasty (TJA) regardless of medical management. The purpose of this study was to investigate the utility of routine basic metabolic panel (BMP) tests after TJA. Furthe ...
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Journal articleJ Asthma · July 2018
BACKGROUND: Low adherence and poor outcomes provide opportunity for digital coaching to engage patients with uncontrolled asthma in their care to improve outcomes. OBJECTIVE(S): To examine the impact of a remote digital coaching program on asthma control a ...
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Journal articleJ Arthroplasty · July 2018
BACKGROUND: Opioids are a mainstay in perioperative pain management among patients undergoing total knee arthroplasty (TKA). However, patterns in opioid use before and after TKA have not been well-studied. The objectives of this study are to characterize p ...
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Journal articleAm Heart J · June 2018
BACKGROUND: Automated measurements of electrocardiographic (ECG) intervals by current-generation digital electrocardiographs are critical to computer-based ECG diagnostic statements, to serial comparison of ECGs, and to epidemiological studies of ECG findi ...
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Journal articleHeart Rhythm · May 2018
BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). OBJECTIVE: The purpose of this study was to compare outcomes of AF ablation in pa ...
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Journal articleOrthopedics · May 1, 2018
The co-occurrence of a mental illness and a substance abuse disorder (SUD) is common and has been referred to as a "dual diagnosis" (DD). Although studies have independently investigated mental illness alone and SUD alone, few have examined the effects of ...
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Journal articleBMC Cancer · April 27, 2018
BACKGROUND: In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival in soft tissue sarcoma (STS). We i ...
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Journal articleEur Heart J Acute Cardiovasc Care · April 2018
AIMS: Ventricular arrhythmia (VA) bursts following recanalisation in acute ST-elevation myocardial infarction (STEMI) are related to larger infarct size (IS). Inadequate microvascular reperfusion, as determined by microvascular obstruction (MVO) using card ...
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Journal articleJ Arthroplasty · April 2018
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) are implementing changes in hospital reimbursement models for total joint arthroplasty (TJA), moving to value-based bundled payments from the fee-for-service model. The purpose of this study ...
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Journal articleJ Allergy Clin Immunol · March 2018
BACKGROUND: The use of inflammatory biomarkers to delineate the type of lung inflammation present in asthmatic subjects is increasingly common. However, the effect of obesity on these markers is unknown. OBJECTIVES: We aimed to determine the effect of obes ...
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Journal articleJ Allergy Clin Immunol · March 2018
BACKGROUND: Eosinophils are prominent in some patients with asthma and are increased in the submucosa in a subgroup of obese patients with asthma (OAs). Surfactant protein AÂ (SP-A) modulates host responses to infectious and environmental insults. OBJECTIVE ...
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Journal articleHip Pelvis · March 2018
PURPOSE: Total hip arthroplasty (THA) is a successful surgery for the treatment of hip osteoarthritis; however, the risk of a post-operative prosthetic joint infection (PJI) remains at 1% to 2%. The purpose of this study was to investigate the safety profi ...
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Journal articleJ Arthroplasty · January 2018
BACKGROUND: Total hip and knee arthroplasty (THA and TKA) are associated with significant blood loss and some patients require postoperative blood transfusion. While tranexamic acid has been studied extensively among this population, we tested the hypothes ...
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Journal articleCan J Anaesth · January 2018
BACKGROUND: Preoperative and postoperative anemia have been identified individually as potential risk factors for postoperative complications after coronary artery bypass grafting (CABG) surgery. Their interrelationship with acute kidney injury (AKI) and l ...
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Journal articleFoot Ankle Int · November 2017
BACKGROUND: The Salto Talaris total ankle replacement is a modern fixed-bearing implant used to treat symptomatic ankle arthritis with the goals of providing pain relief, restoring mechanical alignment, and allowing motion of the ankle joint. The goal of t ...
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Journal articleClin Orthop Relat Res · November 2017
BACKGROUND: The use of tranexamic acid (TXA) in THA decreases the risk of transfusion after surgery. However, nearly 10% of patients still undergo a transfusion, which has been independently associated with an increased risk of complications. Preoperative ...
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Journal articleJ Arthroplasty · June 2017
BACKGROUND: The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, developed by the Centers for Medicare & Medicaid Services, is directly tied to hospital reimbursement. The purpose of this study is to analyze survey response ...
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Journal articleJ Orthop Sports Phys Ther · June 2017
Study Design Systematic review and meta-analysis. Background Running is a healthy and popular activity worldwide, but data regarding its association with osteoarthritis (OA) are conflicting. Objectives To evaluate the association of hip and knee OA with ru ...
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Journal articleFoot Ankle Int · April 2017
BACKGROUND: Wound complications following total ankle replacement (TAR) potentially lead to devastating consequences. The aim of this study was to compare the operative and demographic differences in patients with and without major wound problems which req ...
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Journal articleAm J Pharm Educ · March 25, 2017
Objective. To create a learning environment using Bloom's affective domain as a framework that would reduce third-year pharmacy students' stigmatizing attitudes toward patients with mental illness. Design. Prior to the start of the module, students were as ...
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Journal articleJ Orthop Sci · March 2017
PURPOSE: Solid organ transplants (SOT) continue to increase with recipients living longer than ever before. The lifelong immunosuppression in these patients also may place them at increased risk for postoperative complications. The efficacy of total hip ar ...
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Journal articleAnesth Analg · March 2017
BACKGROUND: Continuous peripheral nerve blocks offer advantages over single-injection blocks, including extended analgesia and reduction in opioid consumption. These benefits require that the perineural catheter remain intact for the duration of the planne ...
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Journal articleDermatitis · 2017
BACKGROUND: Linalool and D-limonene are common fragrance ingredients that readily oxidize on exposure to air. The resulting hydroperoxides of linalool and D-limonene have been shown to have high frequencies of positive patch test reactions in several Europ ...
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Journal articleJ Electrocardiol · 2017
AIMS: ST-segment recovery (STR) is a strong mechanistic correlate of infarct size (IS) and outcome in ST-segment elevation myocardial infarction (STEMI). Characterizing measures of speed, amplitude, and completeness of STR may extend the use of this noninv ...
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Journal articleKnee · October 2016
BACKGROUND: Psychiatric disease is difficult to screen preoperatively and the incidence of mental health disorders in patients undergoing total knee arthroplasty (TKA) may be underappreciated. The purpose of this study is to evaluate the perioperative comp ...
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Journal articleFoot Ankle Int · October 2016
BACKGROUND: Tobacco use is a known risk factor for increased perioperative complications and having worse functional outcomes in many orthopedic procedures. To date, no study has elucidated the effect of cigarette smoking on complications or functional out ...
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Journal articleJ Arthroplasty · September 2016
BACKGROUND: Obesity continues to increase in the United States with an estimated 35% obesity and 8% bariatric (body mass index >40) rate in adults. Bariatric patients seek advice from arthroplasty surgeons regarding the temporality of bariatric surgery (BS ...
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Journal articleClin Endocrinol (Oxf) · July 2016
OBJECTIVE: Leptin is an adipokine that regulates body weight and appetite. It is also an inflammatory cytokine that influences immune reactivity and autoimmunity. Leptin levels are increased in obesity and are higher in women than in men. We aimed to deter ...
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Journal articleAm Heart J · July 2016
The Cardiac Safety Research Consortium (CSRC), a transparent, public-private partnership established in 2005 as a Critical Path Program and formalized in 2006 under a Memorandum of Understanding between the United States Food and Drug Administration and Du ...
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Journal articleJ Bone Joint Surg Am · May 18, 2016
BACKGROUND: Obesity has an important impact on the future of total joint arthroplasty; however, the definition and influence of obesity on surgical risks and outcomes remain controversial. Our hypothesis was that percent body fat was better than body mass ...
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Journal articleStat Methods Med Res · April 2016
We propose a novel likelihood method for analyzing time-to-event data when multiple events and multiple missing data intervals are possible prior to the first observed event for a given subject. This research is motivated by data obtained from a heart moni ...
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Journal articleJ Arthroplasty · March 2016
BACKGROUND: Acetabular cup malpositioning during total hip arthroplasty may lead to impingement, instability, wear-induced osteolysis, and increased rates of revision surgery. The purpose of this study was to independently evaluate the accuracy of acetabul ...
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Journal articleFoot Ankle Int · February 2016
BACKGROUND: The operative treatment of bone cysts after total ankle replacements (TAR) is not well described. Bone cysts may cause component migration, implant failure, and pain. Surgery is performed on cysts with the goals of reducing pain and preventing ...
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Journal articleFoot Ankle Int · February 2016
BACKGROUND: The prevalence of obesity in the United States is staggering. Currently, the effect of obesity on third-generation total ankle replacement (TAR) is unknown. METHODS: We prospectively identified a consecutive series of 455 primary TARs operated ...
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Journal articleJ Electrocardiol · 2016
OBJECTIVE: We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. METHODS: 126 STEMI patients were studied with 24h continuous, 12-lead Ho ...
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Journal articleJ Arthroplasty · December 2015
The objective of this study was to characterize the impact of opioid-based analgesia in total joint arthroplasty. The primary outcomes were incidence of in-hospital complications, length of stay, and discharge destination. Six hundred and seventy-three pri ...
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Journal articleFoot Ankle Int · October 2015
BACKGROUND: As the incidence of diabetes mellitus (DM) grows, managing patients with diabetes and concomitant ankle arthritis poses a challenging clinical dilemma. While diabetes is known to be a risk factor for complications relating to open reduction and ...
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Journal articleJ Surg Res · October 2015
BACKGROUND: Controversy exists over optimal timing of tracheostomy in patients with respiratory failure after blunt trauma. The study aimed to determine whether the timing of tracheostomy affects mortality in this population. METHODS: The 2008-2011 Nationa ...
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Journal articleAm J Orthop (Belle Mead NJ) · October 2015
Patients who undergo total joint arthroplasty and are destined for discharge to an extended-care facility--particularly Medicare beneficiaries--are required to have an inpatient stay of at least 3 consecutive days. The primary objective of this study was t ...
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Journal articleInt J Cardiol · September 15, 2015
BACKGROUND: Early reperfusion of ischemic myocytes is essential for optimal salvage in acute myocardial infarction. VA (ventricular arrhythmia) bursts after recanalization of the culprit vessel have been found to be related to larger infarct size (IS), usi ...
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Journal articleJ Arthroplasty · September 2015
A pilot study was undertaken to examine the impact of Medicare's 3-day rule on length of stay (LOS). One hundred consecutive patients who underwent primary total joint arthroplasty and were discharged to extended care facilities were retrospectively review ...
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Journal articleAnesthesiology · September 2015
BACKGROUND: Despite ultrasound guidance for central line placement, complications persist, as exact needle location is often difficult to confirm with standard two-dimension ultrasound. A novel real-time needle guidance technology has recently become avail ...
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Journal articleFoot Ankle Int · August 2015
BACKGROUND: This series reviews the clinical and radiographic outcomes of patients who underwent total ankle replacement (TAR) using first- and second-generations of a modern fixed-bearing prosthesis utilizing a modular intramedullary stem. METHODS: A cons ...
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Journal articleJ Bone Joint Surg Am · June 17, 2015
BACKGROUND: Propionibacterium acnes has arisen as the most common microorganism identified at the time of revision shoulder arthroplasty. There is limited evidence to suggest how frequently false-positive cultures occur. The purpose of this prospective con ...
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Journal articleFoot Ankle Int · May 2015
BACKGROUND: Liposomal bupivacaine is increasingly being utilized in attempts to provide prolonged local analgesia in the immediate postoperative period. The purpose of this study was to quantify the reduction in opioid consumption as well as postoperative ...
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Journal articleJ Arthroplasty · April 2015
The purpose of this study was to identify preoperative predictors of length of stay after primary total hip arthroplasty in a patient population reflecting current trends toward shorter hospitalization and using readily obtainable factors that do not requi ...
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Journal articleJ Arthroplasty · April 2015
The purpose of this study was to identify preoperative predictors of discharge destination after total joint arthroplasty. A retrospective study of three hundred and seventy-two consecutive patients who underwent primary total hip and knee arthroplasty was ...
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Journal articleClin Pharmacol Ther · April 2015
The QT effects of five "QT-positive" and one negative drug were tested to evaluate whether exposure-response analysis can detect QT effects in a small study with healthy subjects. Each drug was given to nine subjects (six for placebo) in two dose levels; p ...
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Journal articleJ Arthroplasty · March 2015
The purpose of this study was to identify the preoperative predictors of hospital length of stay after primary total knee arthroplasty in a patient population reflecting current trends toward shorter hospitalization and using readily obtainable factors tha ...
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Journal articleSarcoma · 2015
Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB ...
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Journal articleAm Heart J · October 2014
BACKGROUND: Peak creatine kinase (CK)-MB concentration is related to reperfusion success and clinical outcomes after fibrinolytic therapy for acute myocardial infarction. However, prognostic implications of CK-MB measurements after primary percutaneous cor ...
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Journal articleJ Bone Joint Surg Am · February 19, 2014
BACKGROUND: Patients undergoing total hip or knee arthroplasty frequently receive blood transfusions. The relationship between transfusion and the risk of infection following total joint arthroplasty is unclear. In this study, we sought to examine the impa ...
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Journal articleAm Heart J · February 2014
BACKGROUND AND PURPOSE: Automated measurements of electrocardiographic (ECG) intervals are widely used by clinicians for individual patient diagnosis and by investigators in population studies. We examined whether clinically significant systematic differen ...
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Journal articleJ Cardiovasc Pharmacol · November 2013
Cangrelor is an intravenous P2Y12 inhibitor under investigation as an antiplatelet drug in the setting of acute coronary syndromes. To determine the electrophysiologic safety of parenteral cangrelor, cardiac repolarization effects were measured in 67 healt ...
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Journal articleAm Heart J · October 2013
BACKGROUND: Exercise stress testing is commonly obtained after percutaneous coronary intervention (PCI) performed for acute coronary syndromes (ACS). We compared the relationships between exercise echocardiography and nuclear testing after ACS-related PCI ...
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Journal articleJ Am Coll Cardiol · July 30, 2013
OBJECTIVES: The aim of this study was to determine diagnostic testing patterns after percutaneous coronary intervention (PCI). BACKGROUND: Little is known about patterns of diagnostic testing after PCI in the United States or the relationship of these patt ...
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Journal articleJ Electrocardiol · 2013
BACKGROUND/OBJECTIVES: Timely identification of cardiac ischemia is critical in patients with acute coronary syndrome (ACS). The first test is often the standard, resting 12-lead ECG. Given its limitations, signal analysis enhancements have been proposed. ...
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Journal articleCirc Cardiovasc Imaging · January 1, 2013
BACKGROUND: Patterns of noninvasive stress test (ST) and invasive coronary angiography (CA) utilization after percutaneous coronary intervention (PCI) are not well described in older populations. METHODS AND RESULTS: We linked National Cardiovascular Data ...
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Journal articleJACC Cardiovasc Imaging · October 2012
OBJECTIVES: We evaluated temporal trends and geographic variation in choice of stress testing modality after percutaneous coronary intervention (PCI), as well as associations between modality and procedure use after testing. BACKGROUND: Stress testing is f ...
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Journal articleAm J Cardiol · September 15, 2012
Limited data are available on the use of coronary computed tomographic angiography (CCTA) in patients who have received percutaneous coronary intervention (PCI). To evaluate patterns of cardiac testing including CCTA after PCI, we created a retrospective o ...
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Journal articleAm Heart J · March 2012
BACKGROUND: The Cardiac Safety Research Consortium (CSRC) provides both "learning" and blinded "testing" digital electrocardiographic (ECG) data sets from thorough QT (TQT) studies annotated for submission to the US Food and Drug Administration (FDA) to de ...
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Journal articleJ Electrocardiol · 2012
The Cardiac Safety Research Consortium (CSRC) ECG database was initiated to foster research using anonymized, XML-formatted, digitized ECGs with corresponding descriptive variables from placebo- and positive-control arms of thorough QT studies submitted to ...
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Journal articleContemp Clin Trials · January 2012
Cigarette smoking is prevalent in cocaine/methamphetamine-dependent patients and associated with significant morbidity and mortality, yet, the provision of smoking cessation treatment in conjunction with substance use disorder (SUD) treatment is not standa ...
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Journal articleAm Heart J · December 2010
This document examines the formation, structure, and principles guiding the use of electrocardiogram (ECG) data sets obtained during thorough QT studies that have been derived from the ECG Warehouse of the Cardiac Safety Research Consortium (CSRC). These p ...
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Journal articleAm Heart J · December 2009
BACKGROUND: Inhibition of the P2Y12 ADP-receptor with oral antiplatelet agents given to patients undergoing primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is associated with improved outcomes, but this strat ...
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Journal articleClin Pharmacol Ther · July 2009
Featured Publication
The cardiovascular safety of new drugs is an overarching concern for all stakeholders: the pharmaceutical industry and the US Food and Drug Administration (FDA) prior to approval and doctors and patients during postrelease drug use. Of the many cardiac saf ...
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Journal articleCirculation · February 19, 2008
BACKGROUND: KAI-9803, a delta-protein kinase C inhibitor, has been shown to ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI). METHODS AND RESULTS: Direct Inhibition of delta-Protein Kinase C En ...
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Journal articleAm J Cardiol · March 1, 2005
Featured Publication
We compared combination fibrinolytic plus glycoprotein IIb/IIIa inhibitor therapy with stand-alone fibrinolysis with respect to speed and stability of reperfusion in patients who had acute ST-segment elevation myocardial infarction; data were obtained from ...
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Journal articleDrug Information Journal · 2005
Maximal utility of accessible data is attractive to all partners in clinical research, whether it directly improves patient care or more accurately allows identification of the safety and efficacy of a new drug or procedure. The Food and Drug Administratio ...
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Journal articleAm J Cardiol · December 15, 2004
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Twelve-lead ST-segment monitoring is a widely used tool for capturing focal ischemia and transient intermittent episodes. However, continuous registration of all 10 electrodes is impractical in clinical settings. This study investigated the accuracy of 2 d ...
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Journal articleAnn Thorac Surg · October 2004
BACKGROUND: Chronic allograft dysfunction limits the long-term success of lung transplantation. Increasing evidence suggests nonimmune mediated injury such as due to reflux contributes to the development of bronchiolitis obliterans syndrome. We have previo ...
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Journal articleAm Heart J · May 2004
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BACKGROUND: More complete ST-segment resolution (ST res) in acute myocardial infarction (MI) has been associated with better epicardial and myocardial reperfusion as assessed with the Thrombolysis in Myocardial Infarction (TIMI) flow grade (TFG) and the TI ...
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Journal articleAm Heart J · April 2004
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BACKGROUND: Clinical descriptors and ST-segment recovery variables hold prognostic information for clinical outcome after thrombolysis for acute myocardial infarction (MI). We sought to define the incremental prognostic value of continuous 12-lead ST-segme ...
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Journal articleJ Am Coll Cardiol · February 18, 2004
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OBJECTIVES: This sub-study of the Integrilin and Tenecteplase in Acute Myocardial Infarction (INTEGRITI) trial evaluated of the impact of combination reperfusion therapy with reduced-dose tenecteplase plus eptifibatide on continuous ST-segment recovery and ...
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Journal articleAm J Cardiol · November 15, 2003
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Ventricular arrhythmias are associated with epicardial reperfusion but may also be a sign of cellular injury, which affects recovery of left ventricular (LV) function. To assess the correlation between reperfusion arrhythmias and the change in LV function ...
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Journal articleAm J Cardiol · September 15, 2003
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Myocardial ischemic injury complicating acute myocardial infarction (AMI) and coronary revascularization procedures remains an unresolved clinical dilemma. In preclinical studies, treatment with pyridoxal-5'-phosphate monohydrate (MC-1), a vitamin B6 metab ...
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Journal articleCardiol Rev · 2003
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We studied the relationship between mood and mood shift immediately before percutaneous coronary intervention (PCI) and 3 end points: total ischemic burden during PCI, adverse cardiac end points (ACE) after PCI, and death by 6-month follow up. Patients (n ...
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Journal articleAm Heart J · November 2001
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BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) for unstable coronary syndromes have substantial emotional and spiritual distress that may promote procedural complications. Noetic (nonpharmacologic) therapies may reduce anxiety, pa ...
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Journal articleCirculation · May 9, 2000
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BACKGROUND: Early resolution of ST-segment elevation (ST-segment recovery) is associated with an improved outcome after infarction. Whether this relation is present in patients with Thrombolysis In Myocardial Infarction (TIMI) grade 2 or 3 flow (ie, patent ...
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Journal articleJ Clin Anesth · March 2000
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STUDY OBJECTIVES: To evaluate the relationship between perioperative ischemia and serial concentrations of D-dimer, which is a sensitive and specific marker of fibrinolytic activity. Myocardial ischemia and infarction are well-recognized complications of p ...
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Journal articleJ Am Coll Cardiol · March 1, 2000
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OBJECTIVE: To compare the prognostic significance of reperfusion assessment by Thrombolysis in Myocardial Infarction (TIMI) flow grade in the infarct related artery and ST-segment resolution analysis, by correlating with clinical outcomes in patients with ...
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Journal articleAm Heart J · September 1999
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BACKGROUND: Intracranial hemorrhage is an uncommon but very dangerous complication in patients receiving thrombolytic therapy for acute myocardial infarction. Neurosurgical evacuation is often an available treatment option. However, the association between ...
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Journal articleAm J Cardiol · March 1, 1999
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Previous studies suggest that slow and/or oscillating balloon inflation during coronary angioplasty may decrease the incidence of coronary dissection and improve clinical outcomes. To compare the effect of slow oscillating versus conventional fast inflatio ...
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Journal articleJournal of Electrocardiology · January 1, 1999
A safety and efficacy study of nondrug, nondevice 'noetic' medical interventions requires unique clinical trial design elements and tools. Although the precise mechanisms through which meditative or spiritual practices might influence clinical outcomes may ...
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Journal articleJ Am Coll Cardiol · December 1998
OBJECTIVES: The trial was designed to assess the safety, pharmacodynamics and effects on reperfusion of the platelet glycoprotein (GP) IIb/IIIa inhibitor lamifiban when given with thrombolysis to patients with ST segment elevation acute myocardial infarcti ...
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Journal articleCirculation · October 6, 1998
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BACKGROUND: Limited information exists on risk factors for mortality after thrombolysis-related intracranial hemorrhage. We wished to determine the characteristics associated with 30-day mortality after thrombolysis-related intracranial hemorrhage. METHODS ...
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Journal articleStroke · September 1998
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BACKGROUND AND PURPOSE: The volume of an intracerebral hemorrhage has been shown to be an important independent predictor of mortality in several reports. A technique for estimating hematoma volume, known as the ABC/2 method, has been proven a reliable, si ...
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Journal articleAm J Cardiol · April 15, 1998
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This report details a prospectively randomized clinical trial comparing mechanical clamp compression to hand applied pressure for attaining vascular hemostasis after coronary intervention. Effectiveness was determined by comparing the incidence of femoral ...
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Journal articleStroke · March 1998
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BACKGROUND AND PURPOSE: Intracranial hemorrhage (ICH) is a serious complication of thrombolytic therapy. We systematically reviewed the radiographic features of 244 cases of symptomatic ICH complicating thrombolysis for acute myocardial infarction in the G ...
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Journal articleJ Electrocardiol · 1998
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Comparability of clinical and research data sets may be undermined if the instruments used to acquire them vary. Even when standard 12-lead electrocardiographic formats are used for monitoring, proprietary signal processing techniques and sampling interval ...
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Journal articleJ Am Coll Cardiol · November 15, 1997
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OBJECTIVES: We sought to determine the prognostic significance of simultaneous versus independent resolution of ST segment depression that occurs concomitant with ST segment elevation during acute myocardial infarction (AMI). BACKGROUND: ST segment depress ...
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Journal articleAm J Cardiol · August 15, 1997
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Lead distributions of peak ST-segment depression were compared between patients undergoing left circumflex artery percutaneous transluminal coronary angioplasty and exercise tolerance test. Localization of peak ST-segment depression to leads V2 or V3 was 9 ...
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Journal articleJ Am Coll Cardiol · February 1997
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OBJECTIVES: This study sought to investigate the impact of surgical revascularization on outcome after myocardial infarction. BACKGROUND: Small variations in rates of coronary artery bypass graft surgery (CABG) were noted among thrombolytic regimens in the ...
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Journal articleCirculation · November 15, 1996
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BACKGROUND: Whether thrombolytic therapy alters the incidence and clinical outcome of bundle-branch block is unclear. METHODS AND RESULTS: We examined the occurrence of new-onset bundle-branch block, both transient and persistent, in 681 patients with acut ...
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Journal articleJournal of Intravenous Nursing · May 1, 1996
Background: The abrupt cessation of heparin and other thrombin inhibitors when used to treat acute coronary syndromes has been accompanied by a clustering of thrombotic events. It is unknown whether these events are the result of inadequate antithrombin th ...
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Journal articleCirculation · April 1, 1995
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BACKGROUND: The abrupt cessation of heparin and other thrombin inhibitors when used to treat acute coronary syndromes has been accompanied by a clustering of thrombotic events. It is unknown whether these events are the result of inadequate antithrombin th ...
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Journal articleAm J Cardiol · June 1, 1994
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Continuous ST-segment recovery analysis and 5 static methods using ST-segment comparison between a pre- and post-treatment electrocardiogram were compared for their ability to predict infarct-related artery patency in 82 patients with acute myocardial infa ...
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