Scholars@Duke
Gregory M. Palmer

Gregory M. Palmer

Professor of Radiation Oncology
Radiation Oncology
greg.palmer@duke.edu
Box 3455 Med Ctr, Durham, NC 27710
203 Research Drive, MSRB1 Rm 281, Durham, NC 27710

Scholarly Works - Conferences

Tumor Treating Fields (TTFields) Augment the Efficacy of Cisplatin for Treatment of Cervical Cancer, In Vitro and In Vivo

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2024 Link to item Cite

Abstract PO5-27-02: A Tumor Emboli Platform for Morphometric Analysis, Drug screening and for Intravital Optical Imaging in a Murine Model to Simulate Clinicopathological Features of Inflammatory Breast Cancer

Conference Cancer Research · May 2, 2024 AbstractBackground: Inflammatory breast cancer (IBC) is distinguished by the presence of tumor emboli, clusters of tumor cells, found within breast parenchyma and dermal lymphatic vessels. These emboli serve ... Full text Cite

Abstract 4137: Feasibility of a novel image guided injection tool for non-surgical implantation of orthotopic tumors

Conference Cancer Research · March 22, 2024 AbstractThe purpose of this study was to evaluate a novel device for non-surgical implantation of tumor cells using ultrasonic (US) image guidance. There are a variety of mouse model cancer types (e.g. sub-c ... Full text Cite

Abstract P3-08-06: Monitoring Lymphovascular Invasion and Tumor Growth of Inflammatory Breast Cancer in a Murine Lymphatic Reporter Window Chamber Model

Conference Cancer Research · March 1, 2023 AbstractBackground: Lymphovascular invasion (LVI) is a major route of metastatic dissemination and recent studies indicate its value as an independent prognostic indicator for advanced breast, colorectal, sq ... Full text Cite

Abstract P6-01-01: Validation of an Optical Imaging Platform to Identify Metabolic Vulnerabilities in Chemo-Resistant and Sensitive Tumors

Conference Cancer Research · March 1, 2023 AbstractLess than 20% of Triple Negative Breast Cancer (TNBC) patients experience long-term responses to mainstay chemotherapy, as tumors develop chemo-resistance. While combinations of chemotherapies and ta ... Full text Cite

In Vivo Metabolic Imaging Reveals Mitochondrial Membrane Potential Reprogramming During Residual Disease Following Chemotherapy

Conference Optical Molecular Probes Imaging and Drug Delivery Omp 2023 · January 1, 2023 We performed intravital fluorescent microscopy in preclinical models of disease regression in Triple Negative Breast Cancer to compare dynamic, long-term in vivo changes across three major metabolic axes in chemotherapy-resistant and chemotherapy-sensitive ... Cite

Abstract 6630: Synergistic immuno photothermal nanotherapy (SYMPHONY) for combination cancer therapy

Conference Cancer Research · August 15, 2020 AbstractCheckpoint inhibitor immunotherapy has been a revolutionary milestone in cancer treatment because it can counter the tumor immunosuppressive environment to improve patients' overall survival and even ... Full text Cite

Abstract P1-03-03: Multichannel serial imaging of transgenic, preclinical murine models provides the first quantitative analysis of the unusual growth kinetics and lymph-vascular invasion of patient-derived inflammatory breast cancer cells and tumor emboli

Conference Cancer Research · February 15, 2020 AbstractBackground: Lymphovascular invasion (LVI), a critical feature of advanced cancers, is a major route of metastatic dissemination. Of the clinically-distinct types of breast cancer, the most lethal var ... Full text Cite

Nanostar probes: A golden platform for Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the treatment of metastatic cancer

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 The discovery of new treatments for cancer is imperative. Recently, we showed in a proof-of-concept study that SYnergistic IMmuno PHOtothermal NanotherapY (SYMPHONY) is a powerful treatment for metastatic bladder cancer and brain tumor in mouse models. Our ... Full text Cite

Implantable "smart tattoo" SERS nanosensors for in vivo detection of nucleic acid biotargets in a large animal model

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019 Although nanotechnology has led to important advances in in vitro diagnostics, the development of nanosensors for in vivo molecular detection remains very challenging. Here, we demonstrated the proof-of-principle of in vivo detection of nucleic acid target ... Full text Cite

Abstract 4152: Synergistic gold nanostar-mediated photothermal and immunotherapy for cancer metastasis treatment

Conference Cancer Research · July 1, 2018 AbstractCancer has become a severe thread to human health resulting in more than eight million deaths each year. Cancer metastasis is the main mechanism in more than 90 percent of cancer deaths. However, cur ... Full text Cite

Synergistic immuno photothermal nanotherapy (SYMPHONY) to treat metastatic cancers and induce anti-cancer vaccine effect

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Biocompatible gold nanostars (GNS) with tip-enhanced electromagnetic and optical properties have been developed and applied for multifunctional cancer diagnostics and therapy (theranostics). Their multiple sharp branches acting like "lightning rods" can co ... Full text Cite

Non-invasive, simultaneous quantification of vascular oxygenation, glucose uptake and mitochondria membrane potential in a flank tumor model

Conference Optics Infobase Conference Papers · January 1, 2018 For the first time, we performed simultaneous in vivo spectroscopy of tissue hemoglobin, 2-NBDG, and TMRE in a preclinical model, to successfully capture vascular and metabolic parameters in vivo in solid tumors. ... Full text Cite

Luminescent boron polymers for biomedical imaging

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 20, 2017 Link to item Cite

The Role Of L-Amino Acid Transporter (lat-1) In The Hypoxia-Induced Export Of Anti-Adhesive S-Nitrosothiols (snos)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

The development of an in vivo mobile dynamic microscopy system that images cancerous tumors via fluorescent and phosphorescent nanoparticles

Conference Optics Infobase Conference Papers · January 1, 2017 Hypoxia correlates with reduced radiosensitivity and therapy response. Imaging anesthisized mice using fluorescent nanoparticles causes problems in modeling hypoxia. Therefore, a mobile imaging apparatus was developed to image un-anesthetized mice. ... Full text Cite

Portable system for wide-field, sub-millimeter functional imaging of the morphological landscape of breast tumor margins

Conference Optics Infobase Conference Papers · April 18, 2016 We have developed a portable, breast margin assessment probe (BMAP) that surgeons can use to evaluate the breast tumor margin status during surgery. The approach presented here leverages a custom16-channel photodiode array raster-scanning-based system with ... Full text Cite

Multimodal oxygen imaging utilizing dual emissive polymers and a CMOS camera

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 16, 2015 Link to item Cite

Oxygen sensing difluoroboron dinaphthoylmethane polylactide

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 16, 2015 Link to item Cite

Vascularization of Porous PolyHEMA Scaffolds

Conference FASEB JOURNAL · April 1, 2015 Link to item Cite

Tuning optical properties of difluoroboron beta-diketonate biomaterials for oxygen sensing

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 10, 2014 Link to item Cite

Boron nanoparticles for oxygen sensing: Material design, optical properties, and bioimaging

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 10, 2014 Link to item Cite

Tissue integration of porous polyHEMA scaffold

Conference FASEB JOURNAL · April 1, 2014 Link to item Cite

TH‐A‐BRB‐04: Vascular Response to Microbeam Radiation Therapy in Vivo Using a Murine Window Chamber Tumor Model

Conference Medical Physics · June 2012 Microbeam Radiation Therapy (MRT) has shown a marked tumor‐specific effect. The tissue‐sparing property of this unique treatment is possibly facilitated by efficient normal‐vessel repair mechanisms, contrary to the catastrophic disruption of poorly ... Full text Cite

Luminescent boron b-diketonate biomaterials: Synthesis, properties and applications

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2011 Link to item Cite

Variation in Microenvironmental Effects and Drug Delivery between Different Classes of Antiangiogenic Drugs

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Abstract A10: Antiangiogenic therapy (VEGF-R1–3 and PDGFR inhibitor) increases tumor hemoglobin saturation and decreases interstitial pressure, and microvessel density

Conference Molecular Cancer Therapeutics · December 10, 2009 AbstractMethods: We evaluate the effects of pazopanib, a novel multi-targeted tyrosine kinase inhibitor, by examining its effects on tumor oxygenation, interstitial pressure (IFP), and vascularity as compare ... Full text Cite

Use of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties

Conference Optics Infobase Conference Papers · January 1, 2006 An approach for optimizing the probe geometry for extracting optical properties is developed. It was found that optical properties could be extracted with accuracies of better than 0.5 cm-1, while requiring no a priori assumptions. © 2005 Optica ... Full text Cite

Monte Carlo based inverse model of diffuse reflectance for determination of UV-VIS optical properties and its application to breast cancer diagnosis

Conference Optics Infobase Conference Papers · January 1, 2004 A method for extracting optical properties from diffuse reflectance spectra is applied to human breast tissue. It was found that using the physically-based model for classification of malignancy performed substantially better than an empirical model. ... Cite

The use of a multi-separation probe for optical diagnosis of breast cancer

Conference Optics Infobase Conference Papers · January 1, 2004 We explored the effects of probe-geometry on UV-VIS fluorescence and diffuse reflectance measurements from breast tissues. It shows that integrated fluorescence intensities measured with a multi-separation probe can be used to discriminate malignant from n ... Cite