Gregory M. Palmer

Journal article Proc Natl Acad Sci U S A · April 15, 2014 Featured Publication Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here, we describe a platform for engineering and testing highly functional biomime ... Full text Open Access Link to item Cite

In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters.

Journal article Nat Protoc · August 18, 2011 Featured Publication Optical techniques for functional imaging in mice have a number of key advantages over other common imaging modalities such as magnetic resonance imaging, positron emission tomography or computed tomography, including high resolution, low cost and an exten ... Full text Link to item Cite

Molecular imaging of hypoxia.

Journal article J Nucl Med · February 2011 Featured Publication A wide variety of imaging approaches have been developed in the past few decades for monitoring tumor oxygenation and hypoxia in vivo. In particular, nuclear medicine has seen the development of several radiolabeled hypoxia markers and is the preferred met ... Full text Link to item Cite

Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy.

Journal article J Control Release · March 19, 2010 Featured Publication Optical spectroscopy was used to monitor changes in tumor physiology with therapy, and its influence on drug delivery and treatment efficacy for hyperthermia treatment combined with free doxorubicin or a low-temperature sensitive liposomal formulation. Mon ... Full text Link to item Cite

Optical imaging of tumor hypoxia dynamics.

Journal article J Biomed Opt · 2010 Featured Publication The influence of the tumor microenvironment and hypoxia plays a significant role in determining cancer progression, treatment response, and treatment resistance. That the tumor microenvironment is highly heterogeneous with significant intratumor and intert ... Full text Link to item Cite

A dual-emissive-materials design concept enables tumour hypoxia imaging.

Journal article Nat Mater · September 2009 Featured Publication Luminescent materials are widely used for imaging and sensing owing to their high sensitivity, rapid response and facile detection by many optical technologies. Typically materials must be chemically tailored to achieve intense, photostable fluorescence, o ... Full text Link to item Cite

Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo.

Journal article J Biomed Opt · 2009 Featured Publication This study demonstrates the use of optical spectroscopy for monitoring tumor oxygenation and metabolism in response to hyperoxic gas breathing. Hemoglobin saturation and redox ratio were quantified for a set of 14 and 9 mice, respectively, measured at base ... Full text Link to item Cite

Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media.

Journal article J Biomed Opt · 2008 Featured Publication A Monte-Carlo-based model of fluorescence is developed that is capable of extracting the intrinsic fluorescence properties of tissue, which are independent of the absorption and scattering properties of tissue. This model is flexible in its applicability t ... Full text Link to item Cite

Use of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties.

Journal article IEEE Trans Biomed Eng · August 2007 Featured Publication This paper outlines a framework by which the optimal illumination/collection geometry can be identified for a particular biomedical application. In this paper, this framework was used to identify the optimal probe geometry for the accurate determination of ... Full text Link to item Cite

Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms.

Journal article Appl Opt · February 10, 2006 Featured Publication A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is ... Full text Link to item Cite

Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis.

Journal article Appl Opt · February 10, 2006 Featured Publication The Monte Carlo-based inverse model of diffuse reflectance described in part I of this pair of companion papers was applied to the diffuse reflectance spectra of a set of 17 malignant and 24 normal-benign ex vivo human breast tissue samples. This model all ... Full text Link to item Cite

Comparison of multiexcitation fluorescence and diffuse reflectance spectroscopy for the diagnosis of breast cancer (March 2003).

Journal article IEEE Trans Biomed Eng · November 2003 Featured Publication Nonmalignant (n = 36) and malignant (n = 20) tissue samples were obtained from breast cancer and breast reduction surgeries. These tissues were characterized using multiple excitation wavelength fluorescence spectroscopy and diffuse reflectance spectroscop ... Full text Link to item Cite