Gregory David Sempowski
Professor in Medicine
Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive). Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation. During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency. This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly.
Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.
In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute. This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense. The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research. The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance.
Current Appointments & Affiliations
- Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
- Professor of Pathology, Pathology, Clinical Science Departments 2020
- Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2005
- Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2018
Contact Information
- 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
- DUMC Box 103020, Durham, NC 27710
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greg.sempowski@duke.edu
(919) 684-4386
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DHVI Shared Resources
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Duke Regional Biocontainment Laboratory
- Background
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Education, Training, & Certifications
- Ph.D., University of Rochester 1996
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Previous Appointments & Affiliations
- Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2013 - 2020
- Professor of Pathology, Pathology, Clinical Science Departments 2013 - 2020
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2007 - 2013
- Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2010 - 2013
- Associate Professor in Medicine, Duke Human Vaccine Institute, Institutes and Centers 2007 - 2010
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2007
- Assistant Professor of Medicine, Duke Human Vaccine Institute, Institutes and Centers 2006 - 2007
- Assistant Research Professor of Medicine, Duke Human Vaccine Institute, Institutes and Centers 2003 - 2006
- Assistant Research Professor of Pathology, Pathology, Clinical Science Departments 2005 - 2006
- Assistant Research Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2000 - 2003
- Recognition
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In the News
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NOV 6, 2020 School of Medicine -
AUG 20, 2020 Duke Health News -
JUL 22, 2020 -
MAR 27, 2020 Magnify Magazine
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- Expertise
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Global Scholarship
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Research
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- Research
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Selected Grants
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
- Duke DARPA Pandemic Prevention Platform (P3) awarded by Defense Advanced Research Projects Agency 2017 - 2023
- Duke Subaward to Ology Bio Project Galaxy awarded by Ology Bioservices 2019 - 2023
- Regional Biocontainment Laboratories Facility and Building System Upgrades Support awarded by National Institutes of Health 2021 - 2023
- Micro-Particle Delivery of a Potent Intracellular Adjuvant for a Universal Flu Vaccine awarded by University of North Carolina - Chapel Hill 2018 - 2022
- EQAPOL OPTION 4 (YEAR 5 09/30/2021 - 09/29/2022) awarded by National Institutes of Health 2017 - 2022
- CIVICS Component C - Option 2 awarded by National Institutes of Health 2019 - 2022
- CIVICS Component A - Option 2 awarded by National Institutes of Health 2019 - 2022
- Human Thymus Core (Core C) awarded by The University of Texas MD Anderson Cancer Center 2020 - 2022
- Virology Core awarded by Boston Children's Hospital 2021 - 2022
- Radiation Survival Cohort - Immune Monitoring Core awarded by Wake Forest University Health Sciences 2020 - 2022
- Core D: Human Translation and Verification awarded by University of Arizona 2017 - 2022
- Emerging Infectious Diseases - Coordination Center awarded by Research Triangle Institute International 2020 - 2022
- Experimental Human Infection with Isogenic Mutants of Neisseria gonorrhoeae awarded by University of North Carolina - Chapel Hill 2015 - 2022
- Gonorrhea Vaccine Cooperative Research Center (GV-CRC); Core C: Host Response Monitoring awarded by Henry M. Jackson Foundation 2019 - 2022
- Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2022
- Coronavirus Vaccine Design awarded by State of North Carolina 2020 - 2021
- Adjuvant Discovery Program (Option #3) awarded by National Institutes of Health 2014 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Core C: Monitoring Host Response awarded by Henry M. Jackson Foundation 2014 - 2020
- Validation of the ADAMANT Platform awarded by Ology Bioservices 2019 - 2020
- Novel nanoparticle platform for antiviral vaccine and therapeutics awarded by University of North Carolina - Chapel Hill 2014 - 2020
- Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health 2014 - 2019
- Testing of Adrenas Therapeutics AAV vectors in mice awarded by Adrenas Therapeutics Inc. 2018 - 2019
- Testing of Aspa Therapeutics AAV vectors in mice awarded by Aspa Therapeutics Inc 2018 - 2019
- Duke Infectious Disease Response Training Consortium (DIDRT) awarded by National Institutes of Health 2016 - 2019
- Innate Immune Inhibition of the Mevalonate Pathway impairs Neurodevelopment during ZIKv infection awarded by National Institutes of Health 2017 - 2019
- RERF year 7 funding awarded by Radiation Effects Research Foundation 2009 - 2016
- Nasal Vaccines: Mode of Action, Composition & Delivery awarded by National Institutes of Health 2006 - 2011
- Mechanisms of Age Induced Thymic Atrophy awarded by National Institutes of Health 2005 - 2011
- Multiscale Integrative Immunology for Adjuvant Development awarded by National Institutes of Health 2005 - 2010
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Gobeil, Sophie M-C, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, et al. “Structural diversity of the SARS-CoV-2 Omicron spike.” Mol Cell 82, no. 11 (June 2, 2022): 2050-2068.e6. https://doi.org/10.1016/j.molcel.2022.03.028.Full Text Link to Item
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Mielke, Dieter, Sherry Stanfield-Oakley, Shalini Jha, Taylor Keyes, Adam Zalaquett, Brooke Dunn, Nicole Rodgers, et al. “Development of flow cytometry-based assays to assess the ability of antibodies to bind to SARS-CoV-2-infected and spike-transfected cells and mediate NK cell degranulation.” Cytometry A 101, no. 6 (June 2022): 483–96. https://doi.org/10.1002/cyto.a.24552.Full Text Link to Item
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Gallovic, Matthew D., Robert D. Junkins, Adam M. Sandor, Erik S. Pena, Christopher J. Sample, Ariel K. Mason, Leslee C. Arwood, et al. “STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant.” J Control Release 347 (May 18, 2022): 356–68. https://doi.org/10.1016/j.jconrel.2022.05.017.Full Text Link to Item
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Sonar, Sandip Ashok, Jennifer L. Uhrlaub, Christopher P. Coplen, Gregory D. Sempowski, Jarrod A. Dudakov, Marcel R. M. van den Brink, Bonnie J. LaFleur, Mladen Jergović, and Janko Nikolich-Žugich. “Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging.” Proc Natl Acad Sci U S A 119, no. 17 (April 26, 2022): e2121028119. https://doi.org/10.1073/pnas.2121028119.Full Text Link to Item
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Giroux, Nicholas S., Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, et al. “Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion.” Res Sq, April 7, 2022. https://doi.org/10.21203/rs.3.rs-1479864/v1.Full Text Open Access Copy Link to Item
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Whitley, Jill, Christopher Zwolinski, Christian Denis, Maureen Maughan, Leonie Hayles, David Clarke, Meghan Snare, et al. “Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials.” Transl Res 242 (April 2022): 38–55. https://doi.org/10.1016/j.trsl.2021.11.009.Full Text Open Access Copy Link to Item
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Matthias, Kathryn A., Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, and Margaret C. Bash. “Meningococcal Detoxified Outer Membrane Vesicle Vaccines Enhance Gonococcal Clearance in a Murine Infection Model.” J Infect Dis 225, no. 4 (February 15, 2022): 650–60. https://doi.org/10.1093/infdis/jiab450.Full Text Link to Item
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Li, Dapeng, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, et al. “Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.” Biorxiv, February 14, 2022. https://doi.org/10.1101/2022.01.26.477915.Full Text Open Access Copy Link to Item
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Shah, Ankoor, Jan Storek, Rob Woolson, Ashley Pinckney, Lynnette Keyes-Elstein, Paul K. Wallace, Gregory D. Sempowski, et al. “Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy.” Rheumatology (Oxford), February 2, 2022. https://doi.org/10.1093/rheumatology/keac015.Full Text Link to Item
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Li, Dapeng, Gregory D. Sempowski, Kevin O. Saunders, Priyamvada Acharya, and Barton F. Haynes. “SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment.” Annu Rev Med 73 (January 27, 2022): 1–16. https://doi.org/10.1146/annurev-med-042420-113838.Full Text Link to Item
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Martinez, David R., Alexandra Schäfer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, et al. “A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.” Sci Transl Med 14, no. 629 (January 26, 2022): eabj7125. https://doi.org/10.1126/scitranslmed.abj7125.Full Text Link to Item
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Heggestad, Jacob T., Rhett J. Britton, David S. Kinnamon, Simone A. Wall, Daniel Y. Joh, Angus M. Hucknall, Lyra B. Olson, et al. “Rapid test to assess the escape of SARS-CoV-2 variants of concern.” Sci Adv 7, no. 49 (December 3, 2021): eabl7682. https://doi.org/10.1126/sciadv.abl7682.Full Text Link to Item
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Macintyre, Andrew N., Matthew J. French, Brittany R. Sanders, Kristina J. Riebe, Ivo D. Shterev, Kevin Wiehe, Bhavna Hora, et al. “Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation.” Adv Radiat Oncol 6, no. 5 (September 2021): 100677. https://doi.org/10.1016/j.adro.2021.100677.Full Text Link to Item
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Connolly, Kristie L., Michelle Pilligua-Lucas, Carolina Gomez, Allison C. Costenoble-Caherty, Anthony Soc, Knashka Underwood, Andrew N. Macintyre, Gregory D. Sempowski, and Ann E. Jerse. “Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection.” J Infect Dis 224, no. 12 Suppl 2 (August 16, 2021): S152–60. https://doi.org/10.1093/infdis/jiab211.Full Text Link to Item
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Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.Full Text Open Access Copy Link to Item
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Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, et al. “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.” Science Advances 7, no. 26 (June 25, 2021): eabg4901. https://doi.org/10.1126/sciadv.abg4901.Full Text
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Yu, Chen, Sejiro Littleton, Nicholas S. Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Yuchen Yang, et al. “Mucosal-associated invariant T cell responses differ by sex in COVID-19.” Med (N Y) 2, no. 6 (June 11, 2021): 755-772.e5. https://doi.org/10.1016/j.medj.2021.04.008.Full Text Open Access Copy Link to Item
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McCarthy, Kevin R., Tarra A. Von Holle, Laura L. Sutherland, Thomas H. Oguin, Gregory D. Sempowski, Stephen C. Harrison, and M Anthony Moody. “Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates.” Proc Natl Acad Sci U S A 118, no. 23 (June 8, 2021). https://doi.org/10.1073/pnas.2026752118.Full Text Link to Item
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Hale, Laura P., Lynn Cheatham, Andrew N. Macintyre, Bonnie LaFleur, Brittany Sanders, Jesse Troy, Joanne Kurtzberg, and Gregory D. Sempowski. “T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.” Geroscience 43, no. 3 (June 2021): 1369–82. https://doi.org/10.1007/s11357-020-00301-1.Full Text Open Access Copy Link to Item
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Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.” Nature 594, no. 7864 (June 2021): 553–59. https://doi.org/10.1038/s41586-021-03594-0.Full Text Open Access Copy
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Williams, Wilton B., R Ryan Meyerhoff, R. J. Edwards, Hui Li, Kartik Manne, Nathan I. Nicely, Rory Henderson, et al. “Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.” Cell 184, no. 11 (May 27, 2021): 2955-2972.e25. https://doi.org/10.1016/j.cell.2021.04.042.Full Text Open Access Copy Link to Item
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Martinez, David R., Alexandra Schaefer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, et al. “A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.” Biorxiv, April 28, 2021. https://doi.org/10.1101/2021.04.27.441655.Full Text Link to Item
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Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates.” Biorxiv, February 18, 2021. https://doi.org/10.1101/2020.12.31.424729.Full Text Open Access Copy Link to Item
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McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.” Nat Commun 12, no. 1 (February 17, 2021): 1079. https://doi.org/10.1038/s41467-021-21289-y.Full Text Open Access Copy Link to Item
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Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys.” Biorxiv, February 17, 2021. https://doi.org/10.1101/2021.02.17.431492.Full Text Open Access Copy Link to Item
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Edwards, Robert J., Katayoun Mansouri, Victoria Stalls, Kartik Manne, Brian Watts, Rob Parks, Katarzyna Janowska, et al. “Cold sensitivity of the SARS-CoV-2 spike ectodomain.” Nat Struct Mol Biol 28, no. 2 (February 2021): 128–31. https://doi.org/10.1038/s41594-020-00547-5.Full Text Link to Item
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Lovett, Angela, Arlene C. Seña, Andrew N. Macintyre, Gregory D. Sempowski, Joseph A. Duncan, and Andreea Waltmann. “Cervicovaginal Microbiota Predicts Neisseria gonorrhoeae Clinical Presentation.” Front Microbiol 12 (2021): 790531. https://doi.org/10.3389/fmicb.2021.790531.Full Text Link to Item
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Thornlow, Dana N., Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, and Aaron G. Schmidt. “Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization.” Front Immunol 12 (2021): 737973. https://doi.org/10.3389/fimmu.2021.737973.Full Text Link to Item
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Lederer, Katlyn, Diana Castaño, Daniela Gómez Atria, Thomas H. Oguin, Sidney Wang, Tomaz B. Manzoni, Hiromi Muramatsu, et al. “SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.” Immunity 53, no. 6 (December 15, 2020): 1281-1295.e5. https://doi.org/10.1016/j.immuni.2020.11.009.Full Text Link to Item
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Giroux, Nicholas S., Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia R. Palomino, et al. “Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity.” Biorxiv, December 9, 2020. https://doi.org/10.1101/2020.12.04.412155.Full Text Open Access Copy Link to Item
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Leduc, Isabelle, Kristie L. Connolly, Afrin Begum, Knashka Underwood, Stephen Darnell, William M. Shafer, Jacqueline T. Balthazar, et al. “The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae.” Plos Pathog 16, no. 12 (December 2020): e1008602. https://doi.org/10.1371/journal.ppat.1008602.Full Text Link to Item
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Thanh, Lam Tuan, Dena L. Toffaletti, Jennifer L. Tenor, Charles Giamberardino, Gregory D. Sempowski, Yohannes Asfaw, Hai Trieu Phan, et al. “Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam.” Med Mycol 58, no. 8 (November 10, 2020): 1149–61. https://doi.org/10.1093/mmy/myaa013.Full Text Link to Item
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Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Cassio M. Fontes, et al. “Multiplexed, quantitative serological profiling of COVID-19 from a drop of blood by a point-of-care test.” Medrxiv, November 7, 2020. https://doi.org/10.1101/2020.11.05.20226654.Full Text Link to Item
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Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.” Science 370, no. 6516 (October 30, 2020). https://doi.org/10.1126/science.aay9097.Full Text Link to Item
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Edwards, Robert J., Katayoun Mansouri, Victoria Stalls, Kartik Manne, Brian Watts, Rob Parks, Katarzyna Janowska, et al. “Cold sensitivity of the SARS-CoV-2 spike ectodomain.” Biorxiv, October 13, 2020. https://doi.org/10.1101/2020.07.12.199588.Full Text Link to Item
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Laczkó, Dorottya, Michael J. Hogan, Sushila A. Toulmin, Philip Hicks, Katlyn Lederer, Brian T. Gaudette, Diana Castaño, et al. “A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.” Immunity 53, no. 4 (October 13, 2020): 724-732.e7. https://doi.org/10.1016/j.immuni.2020.07.019.Full Text Link to Item
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McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches.” Medrxiv, July 26, 2020. https://doi.org/10.1101/2020.07.20.20155507.Full Text Open Access Copy Link to Item
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Sempowski, Gregory D., Kevin O. Saunders, Priyamvada Acharya, Kevin J. Wiehe, and Barton F. Haynes. “Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.” Cell 181, no. 7 (June 25, 2020): 1458–63. https://doi.org/10.1016/j.cell.2020.05.041.Full Text Link to Item
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Schwartz, A., M. Stiegel, N. Greeson, A. Vogel, W. Thomann, M. Brown, G. D. Sempowski, et al. “Decontamination and Reuse of N95 Respirators with Hydrogen Peroxide Vapor to Address Worldwide Personal Protective Equipment Shortages During the SARS-CoV-2 (COVID-19) Pandemic.” Applied Biosafety 25, no. 2 (June 1, 2020): 67–70. https://doi.org/10.1177/1535676020919932.Full Text Open Access Copy
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Kwock, Jeffery T., Chelsea Handfield, Jutamas Suwanpradid, Peter Hoang, Michael J. McFadden, Kevin F. Labagnara, Lauren Floyd, et al. “IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.” Sci Adv 6, no. 14 (April 2020): eaay3245. https://doi.org/10.1126/sciadv.aay3245.Full Text Link to Item
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Johnson-Weaver, Brandi T., Gregory D. Sempowski, and Herman F. Staats. “Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice.” Allergy 74, no. 11 (November 2019): 2220–23. https://doi.org/10.1111/all.13738.Full Text Link to Item
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Michalson, Kristofer T., Andrew N. Macintyre, Gregory D. Sempowski, J Daniel Bourland, Timothy D. Howard, Gregory A. Hawkins, Gregory O. Dugan, J Mark Cline, and Thomas C. Register. “Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.” Radiat Res 192, no. 2 (August 2019): 121–34. https://doi.org/10.1667/RR15310.1.Full Text Link to Item
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Caudell, David L., Kristofer T. Michalson, Rachel N. Andrews, William W. Snow, J Daniel Bourland, Ryne J. DeBo, J Mark Cline, Gregory D. Sempowski, and Thomas C. Register. “Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation.” Radiat Res 192, no. 1 (July 2019): 40–52. https://doi.org/10.1667/RR15100.1.Full Text Link to Item
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Choi, Hae Woong, Cliburn Chan, Ivo D. Shterev, Heather E. Lynch, Taylor J. Robinette, Brandi T. Johnson-Weaver, Jianling Shi, et al. “Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.” Slas Discov 24, no. 6 (July 2019): 628–40. https://doi.org/10.1177/2472555219834699.Full Text Link to Item
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Poston, Taylor B., De’Ashia E. Lee, Toni Darville, Wujuan Zhong, Li Dong, Catherine M. O’Connell, Harold C. Wiesenfeld, Sharon L. Hillier, Gregory D. Sempowski, and Xiaojing Zheng. “Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.” J Infect Dis 220, no. 2 (June 19, 2019): 330–39. https://doi.org/10.1093/infdis/jiz087.Full Text Link to Item
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Bajic, Goran, Max J. Maron, Yu Adachi, Taishi Onodera, Kevin R. McCarthy, Charles E. McGee, Gregory D. Sempowski, et al. “Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.” Cell Host Microbe 25, no. 6 (June 12, 2019): 827-835.e6. https://doi.org/10.1016/j.chom.2019.04.003.Full Text Link to Item
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Watanabe, Akiko, Kevin R. McCarthy, Masayuki Kuraoka, Aaron G. Schmidt, Yu Adachi, Taishi Onodera, Keisuke Tonouchi, et al. “Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.” Cell 177, no. 5 (May 16, 2019): 1124-1135.e16. https://doi.org/10.1016/j.cell.2019.03.048.Full Text Link to Item
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Hale, Laura P., Gowrisankar Rajam, George M. Carlone, Chen Jiang, Kouros Owzar, Greg Dugan, David Caudell, et al. “Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.” Plos One 14, no. 2 (2019): e0210663. https://doi.org/10.1371/journal.pone.0210663.Full Text Link to Item
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Collier, Michael A., Robert D. Junkins, Matthew D. Gallovic, Brandon M. Johnson, Monica M. Johnson, Andrew N. Macintyre, Gregory D. Sempowski, Eric M. Bachelder, Jenny P-Y Ting, and Kristy M. Ainslie. “Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.” Mol Pharm 15, no. 11 (November 5, 2018): 4933–46. https://doi.org/10.1021/acs.molpharmaceut.8b00579.Full Text Link to Item
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Jin, Cong, Christopher P. Shelburne, Guojie Li, Erin N. Potts, Kristina J. Riebe, Gregory D. Sempowski, W Michael Foster, and Soman N. Abraham. “Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.” J Clin Invest 128, no. 10 (October 1, 2018): 4742–43. https://doi.org/10.1172/JCI123039.Full Text Link to Item
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Zhu, Weiyan, Joshua Tomberg, Kayla J. Knilans, James E. Anderson, Karen P. McKinnon, Gregory D. Sempowski, Robert A. Nicholas, and Joseph A. Duncan. “Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation.” J Biol Chem 293, no. 28 (July 13, 2018): 11218–29. https://doi.org/10.1074/jbc.RA117.001209.Full Text Link to Item
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Shterev, Ivo D., David B. Dunson, Cliburn Chan, and Gregory D. Sempowski. “Bayesian Multi-Plate High-Throughput Screening of Compounds.” Sci Rep 8, no. 1 (June 22, 2018): 9551. https://doi.org/10.1038/s41598-018-27531-w.Full Text Link to Item
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McCarthy, Kevin R., Akiko Watanabe, Masayuki Kuraoka, Khoi T. Do, Charles E. McGee, Gregory D. Sempowski, Thomas B. Kepler, Aaron G. Schmidt, Garnett Kelsoe, and Stephen C. Harrison. “Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.” Immunity 48, no. 1 (January 16, 2018): 174-184.e9. https://doi.org/10.1016/j.immuni.2017.12.009.Full Text Link to Item
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Kajimura, Junko, Heather E. Lynch, Susan Geyer, Benjamin French, Mika Yamaoka, Ivo D. Shterev, Gregory D. Sempowski, et al. “Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan.” Radiat Res 189, no. 1 (January 2018): 84–94. https://doi.org/10.1667/RR4854.Full Text Link to Item
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Kurkjian, Cathryn J., Hao Guo, Nathan D. Montgomery, Ning Cheng, Hong Yuan, Joseph R. Merrill, Gregory D. Sempowski, W June Brickey, and Jenny P-Y Ting. “The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome.” Sci Rep 7, no. 1 (December 11, 2017): 17355. https://doi.org/10.1038/s41598-017-17729-9.Full Text Open Access Copy Link to Item
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Kajimura, Junko, Heather E. Lynch, Susan Geyer, Benjamin French, Mika Yamaoka, Ivo D. Shterev, Gregory D. Sempowski, et al. “Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan.” Radiat Res, November 30, 2017. https://doi.org/10.1667/RR14854.1.Full Text Link to Item
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Xiao, Shiyun, Ivo D. Shterev, Wen Zhang, Lauren Young, Jae-Hung Shieh, Malcolm Moore, Marcel van den Brink, Gregory D. Sempowski, and Nancy R. Manley. “Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.” J Immunol 199, no. 8 (October 15, 2017): 2701–12. https://doi.org/10.4049/jimmunol.1600934.Full Text Link to Item
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Jin, Cong, Christopher P. Shelburne, Guojie Li, Erin N. Potts, Kristina J. Riebe, Gregory D. Sempowski, W Michael Foster, and Soman N. Abraham. “Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.” J Clin Invest 127, no. 10 (October 2, 2017): 3913. https://doi.org/10.1172/JCI97321.Full Text Link to Item
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Netzer, Christoph, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J. Parnham, Bernhard Brüne, and Andreas von Knethen. “Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.” Shock 48, no. 2 (August 2017): 215–26. https://doi.org/10.1097/SHK.0000000000000842.Full Text Link to Item
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Ito, Reiko, Laura P. Hale, Susan M. Geyer, Jie Li, Andrew Sornborger, Junko Kajimura, Yoichiro Kusunoki, et al. “Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.” Radiat Res 187, no. 5 (May 2017): 589–98. https://doi.org/10.1667/RR4554.1.Full Text Link to Item
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Linz, Brandon M. L., Crystal J. Neely, Laurel B. Kartchner, April E. Mendoza, Amal L. Khoury, Agnieszka Truax, Gregory Sempowski, et al. “Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.” J Immunol 198, no. 6 (March 15, 2017): 2426–33. https://doi.org/10.4049/jimmunol.1601048.Full Text Link to Item
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Linz, Brandon M. L., Crystal J. Neely, Laurel B. Kartchner, April E. Mendoza, Amal L. Khoury, Agnieszka Truax, Gregory Sempowski, et al. “Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.” Journal of Immunology 198, no. 6 (March 15, 2017): 2426–33. https://doi.org/10.4049/j.immunol.1601048.Full Text Link to Item
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Pardi, Norbert, Michael J. Hogan, Rebecca S. Pelc, Hiromi Muramatsu, Hanne Andersen, Christina R. DeMaso, Kimberly A. Dowd, et al. “Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.” Nature 543, no. 7644 (March 9, 2017): 248–51. https://doi.org/10.1038/nature21428.Full Text Link to Item
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Thome, Joseph J. C., Boris Grinshpun, Brahma V. Kumar, Masa Kubota, Yoshiaki Ohmura, Harvey Lerner, Gregory D. Sempowski, Yufeng Shen, and Donna L. Farber. “Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites.” Sci Immunol 1, no. 6 (December 2016). https://doi.org/10.1126/sciimmunol.aah6506.Full Text Link to Item
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Jones, Dorothy I., Charles E. McGee, Christopher J. Sample, Gregory D. Sempowski, David J. Pickup, and Herman F. Staats. “Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge.” Clin Vaccine Immunol 23, no. 7 (July 2016): 648–51. https://doi.org/10.1128/CVI.00216-16.Full Text Link to Item
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Guo, Haitao, Renate König, Meng Deng, Maximilian Riess, Jinyao Mo, Lu Zhang, Alex Petrucelli, et al. “NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.” Cell Host Microbe 19, no. 4 (April 13, 2016): 515–28. https://doi.org/10.1016/j.chom.2016.03.001.Full Text Link to Item
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Bowles, R. D., I. O. Karikari, D. N. VanDerwerken, M. S. Sinclair, R. D. Bell, K. J. Riebe, J. L. Huebner, V. B. Kraus, G. D. Sempowski, and L. A. Setton. “In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.” Eur J Pain 20, no. 3 (March 2016): 365–76. https://doi.org/10.1002/ejp.732.Full Text Link to Item
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Samo, Melissa, Neelima R. Choudhary, Kristina J. Riebe, Ivo Shterev, Herman F. Staats, Gregory D. Sempowski, and Isabelle Leduc. “Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface.” Vaccine 34, no. 9 (February 24, 2016): 1193–1200. https://doi.org/10.1016/j.vaccine.2016.01.024.Full Text Link to Item
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Feinstein, Lydia, Sara Ferrando-Martínez, Manuel Leal, Xuan Zhou, Gregory D. Sempowski, Derek E. Wildman, Monica Uddin, and Allison E. Aiello. “Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.” Biodemography Soc Biol 62, no. 2 (2016): 208–21. https://doi.org/10.1080/19485565.2016.1172199.Full Text Link to Item
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Powell, Daniel A., Lydia M. Roberts, Hannah E. Ledvina, Gregory D. Sempowski, Roy Curtiss, and Jeffrey A. Frelinger. “Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.” Cell Immunol 299 (January 2016): 42–49. https://doi.org/10.1016/j.cellimm.2015.10.002.Full Text Link to Item
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Seed, Thomas M., Shiyun Xiao, Nancy Manley, Janko Nikolich-Zugich, Jason Pugh, Marcel Van den Brink, Yoko Hirabayashi, et al. “An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.” Int J Radiat Biol 92, no. 2 (2016): 59–70. https://doi.org/10.3109/09553002.2015.1106024.Full Text Link to Item
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Wang, Yu, Zheng Zhang, Dong Ji, Guo-Feng Chen, Xia Feng, Lu-Lu Gong, Jian Guo, et al. “Regulation of T cell function by microRNA-720.” Sci Rep 5 (July 22, 2015): 12159. https://doi.org/10.1038/srep12159.Full Text Link to Item
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DeBo, Ryne J., Thomas C. Register, David L. Caudell, Gregory D. Sempowski, Gregory Dugan, Shauna Gray, Kouros Owzar, et al. “Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.” Int J Radiat Biol 91, no. 6 (June 2015): 510–18. https://doi.org/10.3109/09553002.2015.1028597.Full Text Link to Item
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Roberts, Lydia M., Hannah E. Ledvina, Shraddha Tuladhar, Deepa Rana, Shaun P. Steele, Gregory D. Sempowski, and Jeffrey A. Frelinger. “Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.” Immun Inflamm Dis 3, no. 2 (June 2015): 71–81. https://doi.org/10.1002/iid3.51.Full Text Link to Item
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Fusco, William G., Neelima R. Choudhary, Shelley M. Stewart, S Munir Alam, Gregory D. Sempowski, Christopher Elkins, and Isabelle Leduc. “Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.” Monoclon Antib Immunodiagn Immunother 34, no. 2 (April 2015): 73–82. https://doi.org/10.1089/mab.2014.0054.Full Text Link to Item
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Robbins, Gregory R., Reid A. Roberts, Haitao Guo, Kevin Reuter, Tammy Shen, Gregory D. Sempowski, Karen P. McKinnon, Lishan Su, Joseph M. DeSimone, and Jenny P-Y Ting. “Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model.” Nanomedicine 11, no. 3 (April 2015): 589–99. https://doi.org/10.1016/j.nano.2014.11.010.Full Text Link to Item
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Goldberg, Emily L., Melissa J. Romero-Aleshire, Kristin R. Renkema, Melissa S. Ventevogel, Wade M. Chew, Jennifer L. Uhrlaub, Megan J. Smithey, et al. “Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.” Aging Cell 14, no. 1 (February 2015): 130–38. https://doi.org/10.1111/acel.12280.Full Text Link to Item
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Szabolcs, Paul, Rebecca H. Buckley, Robert Duane Davis, Jerelyn Moffet, Judith Voynow, Jeyaraj Antony, Xiaohua Chen, Gregory D. Sempowski, and David W. Zaas. “Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor.” J Allergy Clin Immunol 135, no. 2 (February 2015): 567–70. https://doi.org/10.1016/j.jaci.2014.07.058.Full Text Link to Item
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Callaway, Justin B., Scott A. Smith, Douglas G. Widman, Karen P. McKinnon, Frank Scholle, Gregory D. Sempowski, Dirk P. Dittmer, James E. Crowe, Aravinda M. de Silva, and Jenny P-Y Ting. “Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.” Plos One 10, no. 8 (2015): e0136708. https://doi.org/10.1371/journal.pone.0136708.Full Text Link to Item
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Pugh, Jason L., Alona S. Sukhina, Thomas M. Seed, Nancy R. Manley, Gregory D. Sempowski, Marcel R. M. van den Brink, Megan J. Smithey, and Janko Nikolich-Žugich. “Histone deacetylation critically determines T cell subset radiosensitivity.” J Immunol 193, no. 3 (August 1, 2014): 1451–58. https://doi.org/10.4049/jimmunol.1400434.Full Text Link to Item
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Lynch, Heather E., Ana M. Sanchez, M Patricia D’Souza, Wes Rountree, Thomas N. Denny, Michael Kalos, and Gregory D. Sempowski. “Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays.” J Immunol Methods 409 (July 2014): 62–71. https://doi.org/10.1016/j.jim.2014.04.011.Full Text Open Access Copy Link to Item
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Fusco, William G., Neelima R. Choudhary, Patty A. Routh, Melissa S. Ventevogel, Valerie A. Smith, Gary G. Koch, Glen W. Almond, Paul E. Orndorff, Gregory D. Sempowski, and Isabelle Leduc. “The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid.” Vaccine 32, no. 30 (June 24, 2014): 3752–58. https://doi.org/10.1016/j.vaccine.2014.05.031.Full Text Link to Item
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Roberts, Lydia M., John S. Davies, Gregory D. Sempowski, and Jeffrey A. Frelinger. “IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.” Vaccine 32, no. 29 (June 17, 2014): 3595–3603. https://doi.org/10.1016/j.vaccine.2014.05.013.Full Text Link to Item
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Packiam, Mathanraj, Roshan D. Yedery, Afrin A. Begum, Russell W. Carlson, Jhuma Ganguly, Gregory D. Sempowski, Melissa S. Ventevogel, William M. Shafer, and Ann E. Jerse. “Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection.” Infect Immun 82, no. 6 (June 2014): 2170–79. https://doi.org/10.1128/IAI.01504-14.Full Text Link to Item
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Roberts, Lydia M., Shraddha Tuladhar, Shaun P. Steele, Kristina J. Riebe, Ching-Ju Chen, R Ian Cumming, Sarah Seay, et al. “Identification of early interactions between Francisella and the host.” Infect Immun 82, no. 6 (June 2014): 2504–10. https://doi.org/10.1128/IAI.01654-13.Full Text Link to Item
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Yan, Qin, Batu K. Sharma-Kuinkel, Hitesh Deshmukh, Ephraim L. Tsalik, Derek D. Cyr, Joseph Lucas, Christopher W. Woods, et al. “Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.” Plos Pathog 10, no. 6 (June 2014): e1004149. https://doi.org/10.1371/journal.ppat.1004149.Full Text Open Access Copy Link to Item
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Holmer, Stephanie M., Kathy S. Evans, Yohannes G. Asfaw, Divey Saini, Wiley A. Schell, Julie G. Ledford, Richard Frothingham, Jo Rae Wright, Gregory D. Sempowski, and John R. Perfect. “Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.” Infect Immun 82, no. 2 (February 2014): 683–93. https://doi.org/10.1128/IAI.00855-13.Full Text Link to Item
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Lynch, Heather E., Shelley M. Stewart, Thomas B. Kepler, Gregory D. Sempowski, and S Munir Alam. “Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.” J Immunol Methods 404 (February 2014): 1–12. https://doi.org/10.1016/j.jim.2013.11.026.Full Text Link to Item
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Lynch, H. E., S. M. Stewart, T. B. Kepler, G. D. Sempowski, and S. M. Alam. “Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.” Journal of Immunological Methods 404, no. 1 (2014): 1–12.
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Roberts, Lydia M., Hannah E. Ledvina, Gregory D. Sempowski, and Jeffrey A. Frelinger. “TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.” Front Immunol 5 (2014): 426. https://doi.org/10.3389/fimmu.2014.00426.Full Text Link to Item
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Zhou, Xiyou, Xi Gao, Peter M. Broglie, Chahnaz Kebaier, James E. Anderson, Natalie Thom, Michael A. Apicella, Gregory D. Sempowski, and Joseph A. Duncan. “Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.” Infect Immun 82, no. 1 (January 2014): 184–92. https://doi.org/10.1128/IAI.00890-13.Full Text Link to Item
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Lynch, H. E., and G. D. Sempowski. “Molecular measurement of t cell receptor excision circles.” Methods in Molecular Biology 979 (December 1, 2013): 147–59. https://doi.org/10.1007/978-1-62703-290-2-12.Full Text
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Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.Full Text Link to Item
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Collins, Bradley H., Zoie E. Holzknecht, Kellie A. Lynn, Gregory D. Sempowski, Catherine C. Smith, Songling Liu, William Parker, and Don C. Rockey. “Association of age-dependent liver injury and fibrosis with immune cell populations.” Liver Int 33, no. 8 (September 2013): 1175–86. https://doi.org/10.1111/liv.12202.Full Text Link to Item
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Ventevogel, Melissa S., and Gregory D. Sempowski. “Thymic rejuvenation and aging.” Curr Opin Immunol 25, no. 4 (August 2013): 516–22. https://doi.org/10.1016/j.coi.2013.06.002.Full Text Link to Item
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Barrigan, Lydia M., Shraddha Tuladhar, Jason C. Brunton, Matthew D. Woolard, Ching-ju Chen, Divey Saini, Richard Frothingham, Gregory D. Sempowski, Thomas H. Kawula, and Jeffrey A. Frelinger. “Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response.” Infect Immun 81, no. 6 (June 2013): 2028–42. https://doi.org/10.1128/IAI.00207-13.Full Text Link to Item
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Long, Kristin M., Alan C. Whitmore, Martin T. Ferris, Gregory D. Sempowski, Charles McGee, Bianca Trollinger, Bronwyn Gunn, and Mark T. Heise. “Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice.” J Virol 87, no. 10 (May 2013): 5697–5706. https://doi.org/10.1128/JVI.01611-12.Full Text Link to Item
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Lunsford, Keri E., Brandon J. Baird, Gregory D. Sempowski, Diana M. Cardona, Zhiguo Li, Kent J. Weinhold, Debra L. Sudan, and Todd V. Brennan. “Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury.” Transplantation 95, no. 8 (April 27, 2013): 1000–1007. https://doi.org/10.1097/TP.0b013e318286483a.Full Text Link to Item
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Lynch, Heather E., and Gregory D. Sempowski. “Molecular measurement of T cell receptor excision circles.” Methods Mol Biol 979 (2013): 147–59. https://doi.org/10.1007/978-1-62703-290-2_12.Full Text Link to Item
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Kanda, Junya, Lun-Wei Chiou, Paul Szabolcs, Gregory D. Sempowski, David A. Rizzieri, Gwynn D. Long, Keith M. Sullivan, et al. “Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation.” Biol Blood Marrow Transplant 18, no. 11 (November 2012): 1664-1676.e1. https://doi.org/10.1016/j.bbmt.2012.06.005.Full Text Link to Item
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Mendoza, April Elizabeth, Crystal Judith Neely, Anthony G. Charles, Laurel Briane Kartchner, Willie June Brickey, Amal Lina Khoury, Gregory D. Sempowski, Jenny P. Y. Ting, Bruce A. Cairns, and Robert Maile. “Radiation combined with thermal injury induces immature myeloid cells.” Shock 38, no. 5 (November 2012): 532–42. https://doi.org/10.1097/SHK.0b013e31826c5b19.Full Text Link to Item
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Chinn, Ivan K., Clare C. Blackburn, Nancy R. Manley, and Gregory D. Sempowski. “Changes in primary lymphoid organs with aging.” Semin Immunol 24, no. 5 (October 2012): 309–20. https://doi.org/10.1016/j.smim.2012.04.005.Full Text Link to Item
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Gonzalez, Rodrigo J., Eric H. Weening, Richard Frothingham, Gregory D. Sempowski, and Virginia L. Miller. “Bioluminescence imaging to track bacterial dissemination of Yersinia pestis using different routes of infection in mice.” Bmc Microbiol 12 (July 24, 2012): 147. https://doi.org/10.1186/1471-2180-12-147.Full Text Link to Item
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Brickey, Willie J., Isabel P. Neuringer, William Walton, Xiaoyang Hua, Ellis Y. Wang, Sushmita Jha, Gregory D. Sempowski, et al. “MyD88 provides a protective role in long-term radiation-induced lung injury.” Int J Radiat Biol 88, no. 4 (April 2012): 335–47. https://doi.org/10.3109/09553002.2012.652723.Full Text Link to Item
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Thompson, Afton L., Brandi T. Johnson, Gregory D. Sempowski, Michael D. Gunn, Baidong Hou, Anthony L. DeFranco, and Herman F. Staats. “Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.” J Immunol 188, no. 6 (March 15, 2012): 2834–46. https://doi.org/10.4049/jimmunol.1100254.Full Text Link to Item
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Zhu, Weiyan, Melissa S. Ventevogel, Kayla J. Knilans, James E. Anderson, Laurel M. Oldach, Karen P. McKinnon, Marcia M. Hobbs, Gregory D. Sempowski, and Joseph A. Duncan. “Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation.” Plos One 7, no. 7 (2012): e41260. https://doi.org/10.1371/journal.pone.0041260.Full Text Link to Item
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Shi, Xin, Ping Zhang, Gregory D. Sempowski, and Judd E. Shellito. “Thymopoietic and bone marrow response to murine Pneumocystis pneumonia.” Infect Immun 79, no. 5 (May 2011): 2031–42. https://doi.org/10.1128/IAI.01213-10.Full Text Link to Item
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Billard, Matthew J., Amanda L. Gruver, and Gregory D. Sempowski. “Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses.” Plos One 6, no. 3 (March 18, 2011): e17940. https://doi.org/10.1371/journal.pone.0017940.Full Text Link to Item
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Jin, Cong, Christopher P. Shelburne, Guojie Li, Erin N. Potts, Kristina J. Riebe, Gregory D. Sempowski, W Michael Foster, and Soman N. Abraham. “Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.” J Clin Invest 121, no. 3 (March 2011): 941–55. https://doi.org/10.1172/JCI43584.Full Text Link to Item
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Pastva, Amy M., Sambuddho Mukherjee, Charles Giamberardino, Bethany Hsia, Bernice Lo, Gregory D. Sempowski, and Jo Rae Wright. “Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.” J Immunol 186, no. 5 (March 1, 2011): 2842–49. https://doi.org/10.4049/jimmunol.0904190.Full Text Link to Item
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Gordy, Claire, Heather Pua, Gregory D. Sempowski, and You-Wen He. “Regulation of steady-state neutrophil homeostasis by macrophages.” Blood 117, no. 2 (January 13, 2011): 618–29. https://doi.org/10.1182/blood-2010-01-265959.Full Text Link to Item
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Cain, Derek W., Pilar B. Snowden, Gregory D. Sempowski, and Garnett Kelsoe. “Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.” Plos One 6, no. 5 (2011): e19957. https://doi.org/10.1371/journal.pone.0019957.Full Text Open Access Copy Link to Item
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Liu, Congxiao, Benny J. Chen, Divinomar Deoliveira, Gregory D. Sempowski, Nelson J. Chao, and Robert W. Storms. “Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation.” Blood 116, no. 25 (December 16, 2010): 5518–27. https://doi.org/10.1182/blood-2009-12-260810.Full Text Link to Item
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Ahn, Sun-Hee, Hitesh Deshmukh, Nicole Johnson, Lindsay G. Cowell, Thomas H. Rude, William K. Scott, Charlotte L. Nelson, et al. “Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.” Plos Pathog 6, no. 9 (September 2, 2010): e1001088. https://doi.org/10.1371/journal.ppat.1001088.Full Text Open Access Copy Link to Item
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Davis, Craig C., Luciana C. Marti, Gregory D. Sempowski, Durairaj A. Jeyaraj, and Paul Szabolcs. “Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation.” Cancer Res 70, no. 13 (July 1, 2010): 5249–58. https://doi.org/10.1158/0008-5472.CAN-09-2860.Full Text Link to Item
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Chen, Benny J., Divino Deoliveira, Ivan Spasojevic, Gregory D. Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, et al. “Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.” Plos One 5, no. 6 (June 16, 2010): e11056. https://doi.org/10.1371/journal.pone.0011056.Full Text Open Access Copy Link to Item
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Alderman, T Scott, Richard Frothingham, and Gregory D. Sempowski. “Validation of an Animal Isolation Imaging Chamber for Use in Animal Biosafety Level-3 Containment.” Appl Biosaf 15, no. 2 (2010): 62–66. https://doi.org/10.1177/153567601001500203.Full Text Link to Item
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Na, Il-Kang, Sydney X. Lu, Nury L. Yim, Gabrielle L. Goldberg, Jennifer Tsai, Uttam Rao, Odette M. Smith, et al. “The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.” J Clin Invest 120, no. 1 (January 2010): 343–56. https://doi.org/10.1172/JCI39395.Full Text Open Access Copy Link to Item
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Gruver, Amanda L., Melissa S. Ventevogel, and Gregory D. Sempowski. “Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution.” J Endocrinol 203, no. 1 (October 2009): 75–85. https://doi.org/10.1677/JOE-09-0179.Full Text Link to Item
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Sempowski, G. D. “MODULATION OF THYMOPOIESIS ACROSS THE LIFESPAN.” Gerontologist 49 (October 1, 2009): 346–346.Link to Item
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Sarzotti-Kelsoe, Marcella, Chan M. Win, Roberta E. Parrott, Myriah Cooney, Barry K. Moser, Joseph L. Roberts, Gregory D. Sempowski, and Rebecca H. Buckley. “Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras.” Blood 114, no. 7 (August 13, 2009): 1445–53. https://doi.org/10.1182/blood-2009-01-199323.Full Text Link to Item
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Lynch, Heather E., Gabrielle L. Goldberg, Ann Chidgey, Marcel R. M. Van den Brink, Richard Boyd, and Gregory D. Sempowski. “Thymic involution and immune reconstitution.” Trends Immunol 30, no. 7 (July 2009): 366–73. https://doi.org/10.1016/j.it.2009.04.003.Full Text Link to Item
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Gruver, Amanda L., and Gregory D. Sempowski. “Cytokines, leptin, and stress-induced thymic atrophy.” J Leukoc Biol 84, no. 4 (October 2008): 915–23. https://doi.org/10.1189/jlb.0108025.Full Text Link to Item
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Page, Kristin M., Adam M. Mendizabal, Vinod K. Prasad, Paul L. Martin, Suhag Parikh, Susan Wood, Gregory D. Sempowski, Paul Szabolcs, and Joanne Kurtzberg. “Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation.” Biol Blood Marrow Transplant 14, no. 10 (October 2008): 1108–17. https://doi.org/10.1016/j.bbmt.2008.07.006.Full Text Link to Item
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Gruver, Amanda Louise, and Gregory D. Sempowski. “Intrathymic Role for Leptin in the Prevention of Thymic Atrophy.” Faseb Journal 22 (April 1, 2008).Link to Item
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Howard, Brandon A., Gregory D. Sempowski, Richard M. Scearce, Hua-Xin Liao, David M. Lee, Gordon K. Lam, Haiyen Chen, Patrick Fadden, Timothy Haystead, and Barton F. Haynes. “Murine CD7 shares antigenic cross-reactivity with HSP-60.” Hybridoma (Larchmt) 27, no. 2 (April 2008): 81–89. https://doi.org/10.1089/hyb.2007.0553.Full Text Link to Item
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Henry, Stanley C., Xiaojou Daniell, Maanasa Indaram, John F. Whitesides, Gregory D. Sempowski, David Howell, Tim Oliver, and Gregory A. Taylor. “Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).” J Immunol 179, no. 10 (November 15, 2007): 6963–72. https://doi.org/10.4049/jimmunol.179.10.6963.Full Text Link to Item
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Nordone, Sushila K., Glicerio A. Ignacio, Lishan Su, Gregory D. Sempowski, Douglas T. Golenbock, Liwu Li, and Gregg A. Dean. “Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation.” Aids Res Hum Retroviruses 23, no. 11 (November 2007): 1387–95. https://doi.org/10.1089/aid.2007.0033.Full Text Link to Item
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Hudson, Lori L., M. Louise Markert, Blythe H. Devlin, Barton F. Haynes, and Gregory D. Sempowski. “Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.” Semin Immunol 19, no. 5 (October 2007): 297–309. https://doi.org/10.1016/j.smim.2007.10.002.Full Text Link to Item
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Gruver, A. L., L. L. Hudson, and G. D. Sempowski. “Immunosenescence of ageing.” J Pathol 211, no. 2 (January 2007): 144–56. https://doi.org/10.1002/path.2104.Full Text Link to Item
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Li, Feng-Qiao, Gregory D. Sempowski, Suzanne E. McKenna, Daniel T. Laskowitz, Carol A. Colton, and Michael P. Vitek. “Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.” J Pharmacol Exp Ther 318, no. 3 (September 2006): 956–65. https://doi.org/10.1124/jpet.106.103671.Full Text Link to Item
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Hick, Ryan W., Amanda L. Gruver, Melissa S. Ventevogel, Barton F. Haynes, and Gregory D. Sempowski. “Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy.” J Immunol 177, no. 1 (July 1, 2006): 169–76. https://doi.org/10.4049/jimmunol.177.1.169.Full Text Link to Item
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Hart, Justin P., Gloria Broadwater, Zahid Rabbani, Benjamin J. Moeller, Robert Clough, Dale Huang, Gregory A. Sempowski, et al. “Cytokine profiling for prediction of symptomatic radiation-induced lung injury.” Int J Radiat Oncol Biol Phys 63, no. 5 (December 1, 2005): 1448–54. https://doi.org/10.1016/j.ijrobp.2005.05.032.Full Text Link to Item
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Sempowski, Gregory D., Charles B. Hicks, Joseph J. Eron, John A. Bartlett, Laura P. Hale, Guido Ferrari, Lloyd J. Edwards, Susan Fiscus, and Barton F. Haynes. “Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.” J Clin Immunol 25, no. 5 (September 2005): 462–72. https://doi.org/10.1007/s10875-005-5635-4.Full Text Link to Item
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Lam, Gordon K., Hua-Xin Liao, Yan Xue, S Munir Alam, Richard M. Scearce, Russel E. Kaufman, Gregory D. Sempowski, and Barton F. Haynes. “Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.” J Clin Immunol 25, no. 1 (January 2005): 41–49. https://doi.org/10.1007/s10875-005-0356-5.Full Text Link to Item
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Sempowski, Gregory D., and Maria E. Rhein. “Measurement of mouse T cell receptor excision circles.” Curr Protoc Immunol Chapter 10 (November 2004): Unit-10.31. https://doi.org/10.1002/0471142735.im1031s63.Full Text Link to Item
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Markert, M Louise, Marilyn J. Alexieff, Jie Li, Marcella Sarzotti, Daniel A. Ozaki, Blythe H. Devlin, Debra A. Sedlak, et al. “Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome.” Blood 104, no. 8 (October 15, 2004): 2574–81. https://doi.org/10.1182/blood-2003-08-2984.Full Text Link to Item
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Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Jos Domen, and Nelson J. Chao. “Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.” Blood 103, no. 11 (June 1, 2004): 4344–52. https://doi.org/10.1182/blood-2003-07-2534.Full Text Link to Item
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Markert, M Louise, Marilyn J. Alexieff, Jie Li, Marcella Sarzotti, Daniel A. Ozaki, Blythe H. Devlin, Gregory D. Sempowski, et al. “Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases.” J Allergy Clin Immunol 113, no. 4 (April 2004): 734–41. https://doi.org/10.1016/j.jaci.2004.01.766.Full Text Link to Item
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Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Congxiao Liu, and Nelson J. Chao. “Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.” Blood 103, no. 4 (February 15, 2004): 1534–41. https://doi.org/10.1182/blood-2003-08-2987.Full Text Link to Item
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Sempowski, Gregory D., Scott J. Cross, Craig S. Heinly, Richard M. Scearce, and Barton F. Haynes. “CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.” J Immunol 172, no. 2 (January 15, 2004): 787–94. https://doi.org/10.4049/jimmunol.172.2.787.Full Text Link to Item
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Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, and Nelson J. Chao. “Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.” Exp Hematol 31, no. 10 (October 2003): 953–58. https://doi.org/10.1016/s0301-472x(03)00196-6.Full Text Link to Item
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Markert, M Louise, Marcella Sarzotti, Daniel A. Ozaki, Gregory D. Sempowski, Maria E. Rhein, Laura P. Hale, Francoise Le Deist, et al. “Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients.” Blood 102, no. 3 (August 1, 2003): 1121–30. https://doi.org/10.1182/blood-2002-08-2545.Full Text Link to Item
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Ohm, Joyce E., Dmitry I. Gabrilovich, Gregory D. Sempowski, Ekaterina Kisseleva, Kelly S. Parman, Sorena Nadaf, and David P. Carbone. “VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.” Blood 101, no. 12 (June 15, 2003): 4878–86. https://doi.org/10.1182/blood-2002-07-1956.Full Text Link to Item
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Sufka, Susan A., Guido Ferrari, Victoria E. Gryszowka, Terri Wrin, Susan A. Fiscus, Georgia D. Tomaras, Herman F. Staats, et al. “Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control.” J Infect Dis 187, no. 7 (April 1, 2003): 1027–37. https://doi.org/10.1086/368359.Full Text Link to Item
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Min, Booki, Rebecca McHugh, Gregory D. Sempowski, Crystal Mackall, Gilles Foucras, and William E. Paul. “Neonates support lymphopenia-induced proliferation.” Immunity 18, no. 1 (January 2003): 131–40. https://doi.org/10.1016/s1074-7613(02)00508-3.Full Text Link to Item
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Sempowski, Gregory D., Maria E. Rhein, Richard M. Scearce, and Barton F. Haynes. “Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy.” Eur J Immunol 32, no. 11 (November 2002): 3066–70. https://doi.org/10.1002/1521-4141(200211)32:11<3066::AID-IMMU3066>3.0.CO;2-J.Full Text Link to Item
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Hale, Laura P., Paula K. Greer, and Gregory D. Sempowski. “Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation.” Clin Immunol 104, no. 2 (August 2002): 183–90. https://doi.org/10.1006/clim.2002.5254.Full Text Link to Item
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Markert, M. L., M. Sarzotti, D. A. Ozaki, G. D. Sempowski, M. E. Rhein, L. P. Hale, M. A. Alexieff, and J. Li. “Thymic transplantation in complete DiGeorge syndrome.” Clinical Immunology 103, no. 3 (June 1, 2002): S77–78.Link to Item
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Haynes, Barton F., and Gregory D. Sempowski. “Protection from death in endotoxin shock: does fish oil need a LIF?” Crit Care Med 30, no. 5 (May 2002): 1174–75. https://doi.org/10.1097/00003246-200205000-00045.Full Text Link to Item
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Gooding, M. E., G. D. Sempowski, and B. F. Haynes. “The thymus is the predominant site of T cell rearrangement in early human T cell development.” Faseb Journal 16, no. 4 (March 20, 2002): A346–A346.Link to Item
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Sempowski, G. D., C. S. Heinly, D. M. Lee, R. M. Scearce, and B. F. Haynes. “CD7 and CD28 play a critical role in the development of CD4 T regulatory cells.” Faseb Journal 16, no. 4 (March 20, 2002): A342–A342.Link to Item
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Sempowski, Gregory D., Maria E. Gooding, H. X. Liao, Phong T. Le, and Barton F. Haynes. “T cell receptor excision circle assessment of thymopoiesis in aging mice.” Mol Immunol 38, no. 11 (March 2002): 841–48. https://doi.org/10.1016/s0161-5890(01)00122-5.Full Text Link to Item
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Bradney, Curtis P., Gregory D. Sempowski, Hua-Xin Liao, Barton F. Haynes, and Herman F. Staats. “Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization.” J Virol 76, no. 2 (January 2002): 517–24. https://doi.org/10.1128/jvi.76.2.517-524.2002.Full Text Link to Item
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Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Maria E. Gooding, Congxiao Liu, Barton F. Haynes, and Nelson J. Chao. “A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution.” Blood 99, no. 1 (January 1, 2002): 364–71. https://doi.org/10.1182/blood.v99.1.364.Full Text Link to Item
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Min, Booki, Gregory D. Sempowski, and William E. Paul. “Neonates support "homeostatic" proliferation.” Adv Exp Med Biol 512 (2002): 91–95.Link to Item
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Sempowski, G. D., M. E. Gooding, P. T. Le, and B. F. Haynes. “Erratum: Corrigendum to "T Cell receptor excision circle assessment of thymopoieses in aging mice" (MIMM (2001) 38: 11 (841-848) PII S0161589001001225).” Molecular Immunology 39, no. 5–6 (January 1, 2002): 379–80. https://doi.org/10.1016/S0161-5890(02)00112-8.Full Text
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Sempowski, Gregory D., and Barton F. Haynes. “Immune reconstitution in patients with HIV infection.” Annu Rev Med 53 (2002): 269–84. https://doi.org/10.1146/annurev.med.53.082901.104032.Full Text Link to Item
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Smith, Terry J., Laura Koumas, AnneMarie Gagnon, Andrea Bell, Gregory D. Sempowski, Richard P. Phipps, and Alexander Sorisky. “Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy.” J Clin Endocrinol Metab 87, no. 1 (January 2002): 385–92. https://doi.org/10.1210/jcem.87.1.8164.Full Text Link to Item
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Markert, M. L., A. P. Alvarez-McLeod, G. D. Sempowski, L. P. Hale, J. M. Horvatinovich, K. J. Weinhold, J. A. Bartlett, T. A. D’Amico, and B. F. Haynes. “Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy.” Aids Res Hum Retroviruses 17, no. 17 (November 20, 2001): 1635–43. https://doi.org/10.1089/088922201753342040.Full Text Link to Item
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Staats, H. F., C. P. Bradney, W. M. Gwinn, S. S. Jackson, G. D. Sempowski, H. X. Liao, N. L. Letvin, and B. F. Haynes. “Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization.” J Immunol 167, no. 9 (November 1, 2001): 5386–94. https://doi.org/10.4049/jimmunol.167.9.5386.Full Text Link to Item
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Smith, C. C., G. D. Sempowski, and D. C. Rockey. “Increased hepatic fibrosis in very young mice is associated with induction of liver natural killer cells.” Hepatology 34, no. 4 (October 1, 2001): 394A-394A.Link to Item
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Collazo, C. M., G. S. Yap, G. D. Sempowski, K. C. Lusby, L. Tessarollo, G. F. Vande Woude, A. Sher, and G. A. Taylor. “Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.” J Exp Med 194, no. 2 (July 16, 2001): 181–88. https://doi.org/10.1084/jem.194.2.181.Full Text Link to Item
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Haynes, B. F., and G. D. Sempowski. “Can the thymus win the battle against drug-resistant HIV?” Nat Med 7, no. 6 (June 2001): 661–62. https://doi.org/10.1038/89028.Full Text Link to Item
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Lam, G. K., H. X. Liao, Y. Xue, S. M. Alam, J. R. Thomasch, G. D. Sempowski, S. H. Stauffer, R. Kaufman, and B. F. Haynes. “Characterisation and expression of CD7 ligand, K-12, in human thymic epithelial cells.” Faseb Journal 15, no. 5 (March 8, 2001): A1033–A1033.Link to Item
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Sempowski, G. D., M. E. Gooding, R. M. Scearce, and B. F. Haynes. “Role of leukemia inhibitory factor and corticosteroids in the pathogenesis of lipopolysaccharride-induced acute thymic atrophy.” Faseb Journal 15, no. 5 (March 8, 2001): A1057–A1057.Link to Item
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Sempowski, G. D., M. E. Gooding, P. T. Le, H. X. Liao, and B. F. Haynes. “Molecular characterization of thymic output in aging mice using signal joint T cell receptor delta excision circles.” Faseb Journal 15, no. 4 (March 7, 2001): A667–A667.Link to Item
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Sempowski, G., J. Thomasch, M. Gooding, L. Hale, L. Edwards, E. Ciafaloni, D. Sanders, et al. “Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis.” J Immunol 166, no. 4 (February 15, 2001): 2808–17. https://doi.org/10.4049/jimmunol.166.4.2808.Full Text Link to Item
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Heinly, C. S., G. D. Sempowski, D. M. Lee, D. D. Patel, P. M. McDermott, R. M. Scearce, C. B. Thompson, and B. F. Haynes. “Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice.” Int Immunol 13, no. 2 (February 2001): 157–66. https://doi.org/10.1093/intimm/13.2.157.Full Text Link to Item
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Klein, A. K., D. D. Patel, M. E. Gooding, G. D. Sempowski, B. J. Chen, C. Liu, J. Kurtzberg, B. F. Haynes, and N. J. Chao. “T-Cell recovery in adults and children following umbilical cord blood transplantation.” Biol Blood Marrow Transplant 7, no. 8 (2001): 454–66. https://doi.org/10.1016/s1083-8791(01)80013-6.Full Text Link to Item
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Sempowski, G. D., L. P. Hale, J. S. Sundy, J. M. Massey, R. A. Koup, D. C. Douek, D. D. Patel, and B. F. Haynes. “Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.” J Immunol 164, no. 4 (February 15, 2000): 2180–87. https://doi.org/10.4049/jimmunol.164.4.2180.Full Text Link to Item
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Haynes, B. F., G. D. Sempowski, A. F. Wells, and L. P. Hale. “The human thymus during aging.” Immunol Res 22, no. 2–3 (2000): 253–61. https://doi.org/10.1385/IR:22:2-3:253.Full Text Link to Item
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Haynes, B. F., M. L. Markert, G. D. Sempowski, D. D. Patel, and L. P. Hale. “The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.” Annu Rev Immunol 18 (2000): 529–60. https://doi.org/10.1146/annurev.immunol.18.1.529.Full Text Link to Item
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SEMPOWSKI, G. D. “Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.” J. Immunol. 164 (2000).
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Flores, K. G., J. Li, G. D. Sempowski, B. F. Haynes, and L. P. Hale. “Analysis of the human thymic perivascular space during aging.” J Clin Invest 104, no. 8 (October 1999): 1031–39. https://doi.org/10.1172/JCI7558.Full Text Link to Item
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Sempowski, G. D., D. M. Lee, R. M. Scearce, D. D. Patel, and B. F. Haynes. “Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes.” J Exp Med 189, no. 6 (March 15, 1999): 1011–16. https://doi.org/10.1084/jem.189.6.1011.Full Text Link to Item
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Sempowski, G. D., D. M. Lee, R. E. Kaufman, and B. F. Haynes. “Structure and function of the CD7 molecule.” Crit Rev Immunol 19, no. 4 (1999): 331–48.Link to Item
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Lee, D. M., H. F. Staats, J. S. Sundy, D. D. Patel, G. D. Sempowski, R. M. Scearce, D. M. Jones, and B. F. Haynes. “Immunologic characterization of CD7-deficient mice.” J Immunol 160, no. 12 (June 15, 1998): 5749–56.Link to Item
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Sempowski, G. D., J. Rozenblit, T. J. Smith, and R. P. Phipps. “Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production.” Am J Physiol 274, no. 3 (March 1998): C707–14. https://doi.org/10.1152/ajpcell.1998.274.3.C707.Full Text Link to Item
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Sempowski, G. D., J. Rozenblit, T. J. Smith, and R. P. Phipps. “Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production.” American Journal of Physiology Cell Physiology 274, no. 3 (March 1, 1998): C707–14.Link to Item
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Smith, T. J., G. D. Sempowski, C. S. Berenson, H. J. Cao, H. S. Wang, and R. P. Phipps. “Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression.” Endocrinology 138, no. 12 (December 1997): 5576–88. https://doi.org/10.1210/endo.138.12.5563.Full Text Link to Item
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Sempowski, G. D., P. R. Chess, and R. P. Phipps. “CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts.” J Immunol 158, no. 10 (May 15, 1997): 4670–77.Link to Item
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Sempowski, G. D., P. R. Chess, A. J. Moretti, J. Padilla, R. P. Phipps, and T. M. Blieden. “CD40 mediated activation of gingival and periodontal ligament fibroblasts.” J Periodontol 68, no. 3 (March 1997): 284–92. https://doi.org/10.1902/jop.1997.68.3.284.Full Text Link to Item
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Blieden, T. M., G. D. Sempowski, J. Padilla, V. N. Suchkova, P. Chess, and R. P. Phipps. “Periodontal fibroblast activation via CD40.” Journal of Dental Research 76 (January 1, 1997): 1297–1297.Link to Item
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Padilla, J., G. D. Sempowski, V. N. Suchkova, T. M. Blieden, and R. P. Phipps. “Expression and significance of CD40 on human gingival tissue.” Journal of Dental Research 76 (January 1, 1997): 3423–3423.Link to Item
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SEMPOWSKI, G. D. “CD40 mediated activation of gingival and periodontal ligament fibroblasts.” J Periodontol 68 (1997): 284–92.
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Gaspari, A. A., G. D. Sempowski, P. Chess, J. Gish, and R. P. Phipps. “Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism.” Eur J Immunol 26, no. 6 (June 1996): 1371–77. https://doi.org/10.1002/eji.1830260629.Full Text Link to Item
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Sempowski, G. D., S. Derdak, and R. P. Phipps. “Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets.” J Cell Physiol 167, no. 2 (May 1996): 290–96. https://doi.org/10.1002/(SICI)1097-4652(199605)167:2<290::AID-JCP13>3.0.CO;2-C.Full Text Link to Item
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Sempowski, G. D., T. Gaspari, P. Chess, and R. P. Phipps. “Functional expression of CD40 on human lung fibroblasts and its role in fibroblast activation and interaction with T lymphocytes and mast cells.” Faseb Journal 10, no. 6 (April 30, 1996): 1904–1904.Link to Item
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Gaspari, A. A., G. D. Sempowski, P. R. Chess, J. Gish, and R. P. Phipps. “Cultured human keratinocytes express functional CD40 that mediates protein tyrosine kinase-dependent transmembrane signals and costimulates resting T-lymphocyte proliferation.” Journal of Investigative Dermatology 106, no. 4 (April 1, 1996): 712–712.Link to Item
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Blieden, T. M., G. D. Sempowski, J. Padilla, and R. P. Phipps. “The role of CD40 expression by peridontal fibroblasts.” Journal of Dental Research 75 (January 1, 1996): 96–96.Link to Item
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Fries, K. M., G. D. Sempowski, A. A. Gaspari, T. Blieden, R. J. Looney, and R. P. Phipps. “CD40 expression by human fibroblasts.” Clin Immunol Immunopathol 77, no. 1 (October 1995): 42–51. https://doi.org/10.1016/0090-1229(95)90135-3.Full Text Link to Item
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Smith, T. J., G. D. Sempowski, H. S. Wang, P. J. Del Vecchio, S. D. Lippe, and R. P. Phipps. “Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts.” J Clin Endocrinol Metab 80, no. 9 (September 1995): 2620–25. https://doi.org/10.1210/jcem.80.9.7673404.Full Text Link to Item
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GASPARI, A. A., K. FRIES, G. D. SEMPOWSKI, and R. P. PHIPPS. “HUMAN KERATINOCYTES CONSTITUTIVELY EXPRESS CD40, A COSTIMULATORY LIGAND FOR ACTIVATED T-LYMPHOCYTES.” Journal of Investigative Dermatology 104, no. 4 (April 1, 1995): 570–570.Link to Item
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Sempowski, G. D., M. A. Borrello, T. M. Blieden, R. K. Barth, and R. P. Phipps. “Fibroblast heterogeneity in the healing wound.” Wound Repair Regen 3, no. 2 (April 1995): 120–31. https://doi.org/10.1046/j.1524-475X.1995.30204.x.Full Text Link to Item
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Silvera, M. R., G. D. Sempowski, and R. P. Phipps. “Expression of TGF-beta isoforms by Thy-1+ and Thy-1- pulmonary fibroblast subsets: evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6.” Lymphokine Cytokine Res 13, no. 5 (October 1994): 277–85.Link to Item
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Fries, K. M., T. Blieden, R. J. Looney, G. D. Sempowski, M. R. Silvera, R. A. Willis, and R. P. Phipps. “Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis.” Clin Immunol Immunopathol 72, no. 3 (September 1994): 283–92. https://doi.org/10.1006/clin.1994.1144.Full Text Link to Item
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Sempowski, G. D., M. P. Beckmann, S. Derdak, and R. P. Phipps. “Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.” J Immunol 152, no. 7 (April 1, 1994): 3606–14.Link to Item
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Silvera, M. R., G. D. Sempowski, R. P. Phipps, D. P. Penney, and H. Watts. “Lung Fibroblast Heterogeneity.” Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung 6, no. 1 (January 1, 1993): 1–21. https://doi.org/10.1089/jam.1993.6.1.Full Text
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Li, P., C. N. Thaw, G. D. Sempowski, M. C. Gershengorn, and P. M. Hinkle. “Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels.” Mol Endocrinol 6, no. 9 (September 1992): 1393–1402. https://doi.org/10.1210/mend.6.9.1279382.Full Text Link to Item
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Alderman, T. S., M. A. Stiegel, R. A. Estes, and G. D. Sempowski. “Field-Testing Method for Loose-Fitting Powered Air-Purifying Respirators Equipped with HEPA Filters,,” n.d.
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Chaparian, Ryan R., Alfred T. Harding, Kristina Riebe, Amelia Karlsson, Gregory D. Sempowski, Nicholas S. Heaton, and Brook E. Heaton. “Influenza viral particles harboring the SARS-CoV-2 spike RBD as a combination respiratory disease vaccine,” n.d. https://doi.org/10.1101/2021.04.30.441968.Full Text
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Li, Dapeng, David Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, et al. “Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine,” n.d.
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Conference Papers
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Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.” In Journal of Immunology, Vol. 206, 2021.Link to Item
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Hayashi, Tomonori, Heather E. Lynch, Susan Geyer, Kengo Yoshida, Keiko Furudoi, Keiko Sasaki, Yukari Morishita, et al. “Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort.” In Vaccine, 36:6650–59, 2018. https://doi.org/10.1016/j.vaccine.2018.09.054.Full Text Link to Item
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Lee, De’Ashia E., WuJuan Zhong, Li Dong, Ali Russell Russell, Catherine O’Connell, Harold Wiesenfeld, Sharon Hillier, Gregory D. Sempowski, Xiaojing Zheng, and Toni Darville. “Increased levels of Th1-inducing cytokines are detected in cervical secretions of women with Chlamydia trachomatis infection limited to their cervix.” In Journal of Immunology, Vol. 200. AMER ASSOC IMMUNOLOGISTS, 2018.Link to Item
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Junkins, Robert D., Matthew D. Gallovic, Brandon M. Johnson, Michael A. Collier, Rebekah Watkins-Schulz, Ning Cheng, Clément N. David, et al. “A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination.” In J Control Release, 270:1–13, 2018. https://doi.org/10.1016/j.jconrel.2017.11.030.Full Text Link to Item
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Kajimura, J., H. E. Lynch, S. Geyer, M. Yamaoka, I. Shterev, S. Kyoizumi, G. D. Sempowski, K. Nakachi, and Y. Kusunoki. “Effect of past radiation exposure on the circulating dendritic cell populations in A-bomb survivors.” In European Journal of Immunology, 46:945–945. WILEY-BLACKWELL, 2016.Link to Item
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Yeh, Chen-Hao, Masayuki Kuraoka, Heather Lynch, Gregory D. Sempowski, and Garnett H. Kelsoe. “TCR Repertoire Analysis of Mouse T Follicular Helper Cells and T Follicular Regulatory Cells Following Immunization.” In Journal of Immunology, Vol. 196. AMER ASSOC IMMUNOLOGISTS, 2016.Link to Item
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Bowles, R. D., I. O. Karikari, K. J. Riebe, G. D. Sempowski, and L. A. Setton. “In vivo imaging of NF-кB activity and correlation to pain in a model of radiculopathy.” In Osteoarthritis and Cartilage, 21:S59–60. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.133.Full Text
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Lunsford, K. E., B. Jackson-Baird, G. D. Sempowski, D. M. Cardona, K. J. Weinhold, and T. V. Brennan. “Novel Murine Model of Pancreatic Ischemia Reperfusion Injury Up-Regulates Interleukin-1 Beta, Interleukin-6, and CCL-2.” In American Journal of Transplantation, 12:220–220. WILEY-BLACKWELL, 2012.Link to Item
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Lunsford, Keri E., Brandon Jackson-Baird, Greg D. Sempowski, Diana M. Cardona, and Todd V. Brennan. “Murine Pancreatic Ischemia-Reperfusion Injury Up-Regulates Interleukin-1 beta, Interleukin-6, and CCL-2.” In American Journal of Transplantation, 12:94–94. WILEY-BLACKWELL, 2012.Link to Item
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Gruver, Amanda L., and Gregory D. Sempowski. “Leptin protects against endotoxin-induced thymic remodeling.” In Journal of Immunology, Vol. 182. AMER ASSOC IMMUNOLOGISTS, 2009.Link to Item
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Liu, C., D. DeOliveira, G. D. Sempowski, N. J. Chao, B. J. Chen, and R. W. Storms. “Complete Long-Term Hematopoietic Engraftment by Lineage-Depleted ALDH CD34+ UCB Cells.” In Biology of Blood and Marrow Transplantation, 15:85–85. Elsevier BV, 2009. https://doi.org/10.1016/j.bbmt.2008.12.265.Full Text
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Gruver, Amanda Louise, Melissa S. Ventevogel, and Gregory D. Sempowski. “Leptin Directly Protects Thymus Tissue from Endotoxin-induced Involution.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.Link to Item
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Kendall, Shelie Marie, Melissa S. Ventevogel, and Gregory D. Sempowski. “Thymopoiesis is Enhanced by Inhibition of gp130 Signaling in Young and Aged Mice.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.Link to Item
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Gruver, Amanda L., Melissa S. Ventevogel, Barton F. Haynes, and Gregory D. Sempowski. “Leptin selectively augments thymopoiesis in LPS-induced thymic atrophy.” In Journal of Immunology, 176:S215–S215. AMER ASSOC IMMUNOLOGISTS, 2006.Link to Item
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Peacock, James W., Melissa Ventevogel, Barton F. Haynes, and Gregory D. Sempowski. “Toll like receptor agonist induction of thymic CD4+, CD25+T regulatory cells during vaccination.” In Journal of Immunology, 176:S245–S245. AMER ASSOC IMMUNOLOGISTS, 2006.Link to Item
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Sempowski, G. D., S. J. Cross, C. S. Heinly, R. M. Scearce, and B. F. Haynes. “CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.” In Faseb Journal, 18:A798–99. FEDERATION AMER SOC EXP BIOL, 2004.Link to Item
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Chen, B. J., X. Y. Cui, G. D. Sempowski, J. Domen, and N. Chao. “Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.” In Blood, 102:396B-396B. AMER SOC HEMATOLOGY, 2003.Link to Item
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Cross, S. J., G. D. Sempowski, and B. F. Haynes. “Immunophenotypic and functional characterization of CD4+ CD25+ regulatory T cells as a function of aging in normal human peripheral blood and autoimmune disease.” In Blood, 100:250A-250A. AMER SOC HEMATOLOGY, 2002.Link to Item
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Sempowski, G. D., C. Hicks, L. Edwards, G. Ferrari, J. Eron, and B. F. Haynes. “Naive T cells are maintained in the periphery during acute HIV infection.” In Faseb Journal, 16:A297–A297. FEDERATION AMER SOC EXP BIOL, 2002.Link to Item
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Datasets
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Hale, Laura, Jesse Troy, Brittany Sanders, Lynn Cheatham, Andrew Macintyre, Joanne Kurtzberg, Bonnie LaFleur, and Gregory Sempowski. “Data and Code from: T Cell-Depleted Cultured Pediatric Thymus Tissue as a Model for Some Aspects of Human Age-Related Thymus Involution,” January 4, 2021. https://doi.org/10.7924/r47d2xg50.Data Access
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Preprints
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Gobeil, Sophie M-C, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, et al. “Structural diversity of the SARS-CoV-2 Omicron spike.,” January 26, 2022. https://doi.org/10.1101/2022.01.25.477784.Full Text Link to Item
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Luo, Sai, Jun Zhang, Alex J. B. Kreutzberger, Amanda Eaton, Robert J. Edwards, Changbin Jing, Hai-Qiang Dai, et al. “Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism.” Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2022.06.26.497634.Full Text
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- Teaching & Mentoring
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Recent Courses
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