Gregory David Sempowski | Scholars@Duke

Gregory David Sempowski
Professor in Medicine

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive). Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation. During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency. This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly.

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute. This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense. The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research. The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance.

Current Appointments & Affiliations

Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2013
Professor of Pathology, Pathology, Clinical Science Departments 2013
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2005
Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2018

Contact Information

909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
DUMC Box 103020, Durham, NC 27710
greg.sempowski@duke.edu (919) 684-4386
DHVI Shared Resources
Duke Regional Biocontainment Laboratory

Background
Education, Training, & Certifications
- Ph.D., University of Rochester 1996
Duke Appointment History
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2007 - 2013
- Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2010 - 2013
- Associate Professor in Medicine, Duke Human Vaccine Institute, Institutes and Centers 2007 - 2010
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2007
- Assistant Professor of Medicine, Duke Human Vaccine Institute, Institutes and Centers 2006 - 2007
- Assistant Research Professor of Medicine, Duke Human Vaccine Institute, Institutes and Centers 2003 - 2006
- Assistant Research Professor of Pathology, Pathology, Clinical Science Departments 2005 - 2006
- Assistant Research Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2000 - 2003
Expertise
Global Scholarship
- Research
  - Japan (Country)
Research
Selected Grants
- EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
- Validation of the ADAMANT Platform awarded by Ology Bioservices 2019 - 2020
- Duke DARPA Pandemic Prevention Platform (P3) awarded by Defense Advanced Research Projects Agency 2017 - 2020
- Micro-Particle Delivery of a Potent Intracellular Adjuvant for a Universal Flu Vaccine awarded by University of North Carolina - Chapel Hill 2018 - 2019
- Eqapol Opt 1 -2018-2019 awarded by National Institutes of Health 2017 - 2019
- Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health 2014 - 2019
- Adjuvant Discovery Program (Option #3) awarded by National Institutes of Health 2014 - 2019
- Testing of Adrenas Therapeutics AAV vectors in mice awarded by Adrenas Therapeutics Inc. 2018 - 2019
- Testing of Aspa Therapeutics AAV vectors in mice awarded by Aspa Therapeutics Inc 2018 - 2019
- VTEU Task D Option 1 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
- VTEU Task D Option 4 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
- Virology Core awarded by Boston Children's Hospital 2017 - 2019
- Core C: Monitoring Host Response awarded by Henry M. Jackson Foundation 2014 - 2019
- UNC CETR Core D: Immunology/Influenza Virology awarded by University of North Carolina - Chapel Hill 2014 - 2019
- Core D: Human Translation and Verification awarded by University of Arizona 2017 - 2019
- Duke Infectious Disease Response Training Consortium (DIDRT) awarded by National Institutes of Health 2016 - 2019
- Innate Immune Inhibition of the Mevalonate Pathway Impairs Neurodevelopment during ZIKV Infection awarded by National Institutes of Health 2017 - 2019
- Experimental Human Infection with Isogenic Mutants of Neisseria gonorrhoeae awarded by University of North Carolina - Chapel Hill 2015 - 2019
- RERF year 7 funding awarded by Radiation Effects Research Foundation 2009 - 2016
- Nasal Vaccines: Mode of Action, Composition & Delivery awarded by National Institutes of Health 2006 - 2011
- Mechanisms of Age Induced Thymic Atrophy awarded by National Institutes of Health 2005 - 2011
- Multiscale Integrative Immunology for Adjuvant Develpmnt awarded by National Institutes of Health 2005 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Caudell, DL, Michalson, KT, Andrews, RN, Snow, WW, Bourland, JD, DeBo, RJ, Cline, JM, Sempowski, GD, and Register, TC. "Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation." Radiation Research (May 6, 2019). Full Text
  - Choi, HW, Chan, C, Shterev, ID, Lynch, HE, Robinette, TJ, Johnson-Weaver, BT, Shi, J, Sempowski, GD, Kim, SY, Dickson, JK, Gooden, DM, Abraham, SN, and Staats, HF. "Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening." Slas Discovery : Advancing Life Sciences R & D (March 27, 2019): 2472555219834699-null. Full Text
  - Poston, TB, Lee, DE, Darville, T, Zhong, W, Dong, L, O'Connell, CM, Wiesenfeld, HC, Hillier, SL, Sempowski, GD, and Zheng, X. "Cervical cytokines associated with Chlamydia trachomatis susceptibility and protection." The Journal of Infectious Diseases (March 2019). Full Text
  - Johnson-Weaver, BT, Sempowski, GD, and Staats, HF. "Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice." Allergy (February 12, 2019). (Letter) Full Text
  - Hale, LP, Rajam, G, Carlone, GM, Jiang, C, Owzar, K, Dugan, G, Caudell, D, Chao, N, Cline, JM, Register, TC, and Sempowski, GD. "Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques." Plos One 14, no. 2 (January 2019): e0210663-null. Full Text
  - Collier, MA, Junkins, RD, Gallovic, MD, Johnson, BM, Johnson, MM, Macintyre, AN, Sempowski, GD, Bachelder, EM, Ting, JP-Y, and Ainslie, KM. "Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists." Molecular Pharmaceutics 15, no. 11 (November 2018): 4933-4946. Full Text
  - Jin, C, Shelburne, CP, Li, G, Potts, EN, Riebe, KJ, Sempowski, GD, Foster, WM, and Abraham, SN. "Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation." The Journal of Clinical Investigation 128, no. 10 (October 2018): 4742-4743. Full Text
  - Zhu, W, Tomberg, J, Knilans, KJ, Anderson, JE, McKinnon, KP, Sempowski, GD, Nicholas, RA, and Duncan, JA. "Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation." The Journal of Biological Chemistry 293, no. 28 (July 2018): 11218-11229. Full Text
  - Shterev, ID, Dunson, DB, Chan, C, and Sempowski, GD. "Bayesian Multi-Plate High-Throughput Screening of Compounds." Scientific Reports 8, no. 1 (June 22, 2018): 9551-null. Full Text
  - Kajimura, J, Lynch, HE, Geyer, S, French, B, Yamaoka, M, Shterev, ID, Sempowski, GD, Kyoizumi, S, Yoshida, K, Misumi, M, Ohishi, W, Hayashi, T, Nakachi, K, and Kusunoki, Y. "Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan." Radiation Research 189, no. 1 (January 2018): 84-94. Full Text
  - McCarthy, KR, Watanabe, A, Kuraoka, M, Do, KT, McGee, CE, Sempowski, GD, Kepler, TB, Schmidt, AG, Kelsoe, G, and Harrison, SC. "Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires." Immunity 48, no. 1 (January 2018): 174-184.e9. Full Text
  - Kurkjian, CJ, Guo, H, Montgomery, ND, Cheng, N, Yuan, H, Merrill, JR, Sempowski, GD, Brickey, WJ, and Ting, JP-Y. "The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome." Scientific Reports 7, no. 1 (December 11, 2017): 17355-null. Full Text Open Access Copy
  - Kajimura, J, Lynch, HE, Geyer, S, French, B, Yamaoka, M, Shterev, ID, Sempowski, GD, Kyoizumi, S, Yoshida, K, Misumi, M, Ohishi, W, Hayashi, T, Nakachi, K, and Kusunoki, Y. "Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan." Radiation Research (November 30, 2017). Full Text
  - Jin, C, Shelburne, CP, Li, G, Potts, EN, Riebe, KJ, Sempowski, GD, Foster, WM, and Abraham, SN. "Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation." The Journal of Clinical Investigation 127, no. 10 (October 2017): 3913-null. Full Text
  - Xiao, S, Shterev, ID, Zhang, W, Young, L, Shieh, J-H, Moore, M, van den Brink, M, Sempowski, GD, and Manley, NR. "Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors." Journal of Immunology (Baltimore, Md. : 1950) 199, no. 8 (October 2017): 2701-2712. Full Text
  - Netzer, C, Knape, T, Kuchler, L, Weigert, A, Zacharowski, K, Pfeilschifter, W, Sempowski, G, Parnham, MJ, Brüne, B, and von Knethen, A. "Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis." Shock (Augusta, Ga.) 48, no. 2 (August 2017): 215-226. Full Text
  - Ito, R, Hale, LP, Geyer, SM, Li, J, Sornborger, A, Kajimura, J, Kusunoki, Y, Yoshida, K, van den Brink, MRM, Kyoizumi, S, Manley, NR, Nakachi, K, and Sempowski, GD. "Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function." Radiation Research 187, no. 5 (May 2017): 589-598. Full Text
  - Linz, BML, Neely, CJ, Kartchner, LB, Mendoza, AE, Khoury, AL, Truax, A, Sempowski, G, Eitas, T, Brickey, J, Ting, JPY, Cairns, BA, and Maile, R. "Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis." Journal of Immunology 198, no. 6 (March 15, 2017): 2426-2433. (Academic Article) Full Text Link to Item
  - Linz, BML, Neely, CJ, Kartchner, LB, Mendoza, AE, Khoury, AL, Truax, A, Sempowski, G, Eitas, T, Brickey, J, Ting, JPY, Cairns, BA, and Maile, R. "Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis." Journal of Immunology (Baltimore, Md. : 1950) 198, no. 6 (March 2017): 2426-2433. Full Text
  - Pardi, N, Hogan, MJ, Pelc, RS, Muramatsu, H, Andersen, H, DeMaso, CR, Dowd, KA, Sutherland, LL, Scearce, RM, Parks, R, Wagner, W, Granados, A, Greenhouse, J, Walker, M, Willis, E, Yu, J-S, McGee, CE, Sempowski, GD, Mui, BL, Tam, YK, Huang, Y-J, Vanlandingham, D, Holmes, VM, Balachandran, H, Sahu, S, Lifton, M, Higgs, S, Hensley, SE, Madden, TD, Hope, MJ, Karikó, K, Santra, S, Graham, BS, Lewis, MG, Pierson, TC, Haynes, BF, and Weissman, D. "Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination." Nature 543, no. 7644 (March 2017): 248-251. Full Text
  - Thome, JJC, Grinshpun, B, Kumar, BV, Kubota, M, Ohmura, Y, Lerner, H, Sempowski, GD, Shen, Y, and Farber, DL. "Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites." Science Immunology 1, no. 6 (December 2, 2016). Full Text
  - Jones, DI, McGee, CE, Sample, CJ, Sempowski, GD, Pickup, DJ, and Staats, HF. "Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge." Clinical and Vaccine Immunology : Cvi 23, no. 7 (July 5, 2016): 648-651. Full Text
  - Guo, H, König, R, Deng, M, Riess, M, Mo, J, Zhang, L, Petrucelli, A, Yoh, SM, Barefoot, B, Samo, M, Sempowski, GD, Zhang, A, Colberg-Poley, AM, Feng, H, Lemon, SM, Liu, Y, Zhang, Y, Wen, H, Zhang, Z, Damania, B, Tsao, L-C, Wang, Q, Su, L, Duncan, JA, Chanda, SK, and Ting, JP-Y. "NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses." Cell Host & Microbe 19, no. 4 (April 2016): 515-528. Full Text
  - Bowles, RD, Karikari, IO, VanDerwerken, DN, Sinclair, MS, Bell, RD, Riebe, KJ, Huebner, JL, Kraus, VB, Sempowski, GD, and Setton, LA. "In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy." European Journal of Pain (London, England) 20, no. 3 (March 2016): 365-376. Full Text
  - Samo, M, Choudhary, NR, Riebe, KJ, Shterev, I, Staats, HF, Sempowski, GD, and Leduc, I. "Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface." Vaccine 34, no. 9 (February 2016): 1193-1200. Full Text
  - Alderman, TS, Stiegel, MA, Estes, RA, Thomann, WR, and Sempowski, GD. "Field-testing method for loose-fitting powered air-purifying respirators equipped with HEPA filters." Applied Biosafety 21, no. 2 (January 1, 2016): 71-78. Full Text
  - Feinstein, L, Ferrando-Martínez, S, Leal, M, Zhou, X, Sempowski, GD, Wildman, DE, Uddin, M, and Aiello, AE. "Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status." Biodemography and Social Biology 62, no. 2 (January 2016): 208-221. Full Text
  - Powell, DA, Roberts, LM, Ledvina, HE, Sempowski, GD, Curtiss, R, and Frelinger, JA. "Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants." Cellular Immunology 299 (January 2016): 42-49. Full Text
  - Seed, TM, Xiao, S, Manley, N, Nikolich-Zugich, J, Pugh, J, Van den Brink, M, Hirabayashi, Y, Yasutomo, K, Iwama, A, Koyasu, S, Shterev, I, Sempowski, G, Macchiarini, F, Nakachi, K, Kunugi, KC, Hammer, CG, and Dewerd, LA. "An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned." International Journal of Radiation Biology 92, no. 2 (January 2016): 59-70. Full Text
  - Wang, Y, Zhang, Z, Ji, D, Chen, G-F, Feng, X, Gong, L-L, Guo, J, Li, Z-W, Chen, C-F, Zhao, B-B, Li, Z-G, Li, Q-J, Yan, H-P, Sempowski, G, Wang, F-S, and He, Y-W. "Regulation of T cell function by microRNA-720." Scientific Reports 5 (July 22, 2015): 12159-null. Full Text
  - DeBo, RJ, Register, TC, Caudell, DL, Sempowski, GD, Dugan, G, Gray, S, Owzar, K, Jiang, C, Bourland, JD, Chao, NJ, and Cline, JM. "Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques." International Journal of Radiation Biology 91, no. 6 (June 2015): 510-518. Full Text
  - Roberts, LM, Ledvina, HE, Tuladhar, S, Rana, D, Steele, SP, Sempowski, GD, and Frelinger, JA. "Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response." Immunity, Inflammation and Disease 3, no. 2 (June 2015): 71-81. Full Text
  - Fusco, WG, Choudhary, NR, Stewart, SM, Alam, SM, Sempowski, GD, Elkins, C, and Leduc, I. "Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA." Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 34, no. 2 (April 2015): 73-82. Full Text
  - Robbins, GR, Roberts, RA, Guo, H, Reuter, K, Shen, T, Sempowski, GD, McKinnon, KP, Su, L, DeSimone, JM, and Ting, JP-Y. "Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model." Nanomedicine : Nanotechnology, Biology, and Medicine 11, no. 3 (April 2015): 589-599. Full Text
  - Goldberg, EL, Romero-Aleshire, MJ, Renkema, KR, Ventevogel, MS, Chew, WM, Uhrlaub, JL, Smithey, MJ, Limesand, KH, Sempowski, GD, Brooks, HL, and Nikolich-Žugich, J. "Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms." Aging Cell 14, no. 1 (February 2015): 130-138. Full Text
  - Szabolcs, P, Buckley, RH, Davis, RD, Moffet, J, Voynow, J, Antony, J, Chen, X, Sempowski, GD, and Zaas, DW. "Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor." The Journal of Allergy and Clinical Immunology 135, no. 2 (February 2015): 567-570. (Letter) Full Text
  - Callaway, JB, Smith, SA, Widman, DG, McKinnon, KP, Scholle, F, Sempowski, GD, Dittmer, DP, Crowe, JE, de Silva, AM, and Ting, JP-Y. "Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model." Plos One 10, no. 8 (January 2015): e0136708-null. Full Text
  - Pugh, JL, Sukhina, AS, Seed, TM, Manley, NR, Sempowski, GD, van den Brink, MRM, Smithey, MJ, and Nikolich-Žugich, J. "Histone deacetylation critically determines T cell subset radiosensitivity." Journal of Immunology (Baltimore, Md. : 1950) 193, no. 3 (August 2014): 1451-1458. Full Text
  - Lynch, HE, Sanchez, AM, D'Souza, MP, Rountree, W, Denny, TN, Kalos, M, and Sempowski, GD. "Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays." Journal of Immunological Methods 409 (July 2014): 62-71. (Review) Full Text Open Access Copy
  - Roberts, LM, Davies, JS, Sempowski, GD, and Frelinger, JA. "IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection." Vaccine 32, no. 29 (June 17, 2014): 3595-3603. Full Text
  - Yan, Q, Sharma-Kuinkel, BK, Deshmukh, H, Tsalik, EL, Cyr, DD, Lucas, J, Woods, CW, Scott, WK, Sempowski, GD, Thaden, JT, Rude, TH, Ahn, SH, and Fowler, VG. "Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis." Plos Pathogens 10, no. 6 (June 5, 2014): e1004149-null. Full Text Open Access Copy
  - Fusco, WG, Choudhary, NR, Routh, PA, Ventevogel, MS, Smith, VA, Koch, GG, Almond, GW, Orndorff, PE, Sempowski, GD, and Leduc, I. "The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid." Vaccine 32, no. 30 (June 2014): 3752-3758. Full Text
  - Packiam, M, Yedery, RD, Begum, AA, Carlson, RW, Ganguly, J, Sempowski, GD, Ventevogel, MS, Shafer, WM, and Jerse, AE. "Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection." Infection and Immunity 82, no. 6 (June 2014): 2170-2179. Full Text
  - Roberts, LM, Davies, JS, Sempowski, GD, and Frelinger, JA. "IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection." Vaccine 32, no. 29 (June 2014): 3595-3603. Full Text
  - Roberts, LM, Tuladhar, S, Steele, SP, Riebe, KJ, Chen, C-J, Cumming, RI, Seay, S, Frothingham, R, Sempowski, GD, Kawula, TH, and Frelinger, JA. "Identification of early interactions between Francisella and the host." Infection and Immunity 82, no. 6 (June 2014): 2504-2510. Full Text
  - Holmer, SM, Evans, KS, Asfaw, YG, Saini, D, Schell, WA, Ledford, JG, Frothingham, R, Wright, JR, Sempowski, GD, Perfect, JR, and Pirofski, L. "Impact of surfactant protein d, interleukin-5, and eosinophilia on cryptococcosis." Infection and Immunity 82, no. 2 (February 2014): 683-693. Full Text
  - Holmer, SM, Evans, KS, Asfaw, YG, Saini, D, Schell, WA, Ledford, JG, Frothingham, R, Wright, JR, Sempowski, GD, and Perfect, JR. "Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis." Infection and Immunity 82, no. 2 (February 2014): 683-693. Full Text
  - Lynch, HE, Stewart, SM, Kepler, TB, Sempowski, GD, and Alam, SM. "Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen." Journal of Immunological Methods 404 (February 2014): 1-12. Full Text
  - Lynch, HE, Stewart, SM, Kepler, TB, Sempowski, GD, and Alam, SM. "Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen." Journal of Immunological Methods 404, no. 1 (February 1, 2014): 1-12. Full Text
  - Fusco, WG, Choudhary, NR, Routh, PA, Ventevogel, MS, Smith, VA, Koch, GG, Almond, GW, Orndorff, PE, Sempowski, GD, and Leduc, I. "The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid." Vaccine 32, no. 30 (January 1, 2014): 3752-3758. Full Text
  - Lynch, HE, Sanchez, AM, D'Souza, MP, Rountree, W, Denny, TN, Kalos, M, and Sempowski, GD. "Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays." Journal of Immunological Methods 409 (January 1, 2014): 62-71. (Review) Full Text
  - Lynch, HE, Stewart, SM, Kepler, TB, Sempowski, GD, and Alam, SM. "Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen." Journal of Immunological Methods 404, no. 1 (2014): 1-12.
  - Roberts, LM, Ledvina, HE, Sempowski, GD, and Frelinger, JA. "TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB." Frontiers in Immunology 5 (January 2014): 426-null. Full Text
  - Zhou, X, Gao, X, Broglie, PM, Kebaier, C, Anderson, JE, Thom, N, Apicella, MA, Sempowski, GD, and Duncan, JA. "Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea." Infection and Immunity 82, no. 1 (January 2014): 184-192. Full Text
  - Lynch, HE, and Sempowski, GD. "Molecular measurement of t cell receptor excision circles." Methods in Molecular Biology 979 (December 1, 2013): 147-159. Full Text
  - Cain, DW, O'Koren, EG, Kan, MJ, Womble, M, Sempowski, GD, Hopper, K, Gunn, MD, and Kelsoe, G. "Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages." J Immunol 191, no. 9 (November 1, 2013): 4665-4675. Full Text Link to Item
  - Collins, BH, Holzknecht, ZE, Lynn, KA, Sempowski, GD, Smith, CC, Liu, S, Parker, W, and Rockey, DC. "Association of age-dependent liver injury and fibrosis with immune cell populations." Liver International : Official Journal of the International Association for the Study of the Liver 33, no. 8 (September 2013): 1175-1186. Full Text
  - Ventevogel, MS, and Sempowski, GD. "Thymic rejuvenation and aging." Current Opinion in Immunology 25, no. 4 (August 2013): 516-522. (Review) Full Text
  - Barrigan, LM, Tuladhar, S, Brunton, JC, Woolard, MD, Chen, C-J, Saini, D, Frothingham, R, Sempowski, GD, Kawula, TH, and Frelinger, JA. "Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response." Infection and Immunity 81, no. 6 (June 2013): 2028-2042. Full Text
  - Long, KM, Whitmore, AC, Ferris, MT, Sempowski, GD, McGee, C, Trollinger, B, Gunn, B, and Heise, MT. "Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice." Journal of Virology 87, no. 10 (May 2013): 5697-5706. Full Text
  - Lunsford, KE, Baird, BJ, Sempowski, GD, Cardona, DM, Li, Z, Weinhold, KJ, Sudan, DL, and Brennan, TV. "Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury." Transplantation 95, no. 8 (April 2013): 1000-1007. Full Text
  - Collins, BH, Holzknecht, ZE, Lynn, KA, Sempowski, GD, Smith, CC, Liu, S, Parker, W, and Rockey, DC. "Association of age-dependent liver injury and fibrosis with immune cell populations." Liver International 33, no. 8 (2013): 1175-1186. Full Text
  - Lunsford, KE, Baird, BJ, Sempowski, GD, Cardona, DM, Li, Z, Weinhold, KJ, Sudan, DL, and Brennan, TV. "Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury." Transplantation 95, no. 8 (2013): 1000-1007. Full Text
  - Lynch, HE, and Sempowski, GD. "Molecular measurement of T cell receptor excision circles." Methods in Molecular Biology (Clifton, N.J.) 979 (January 2013): 147-159. Full Text
  - Ventevogel, MS, and Sempowski, GD. "Thymic rejuvenation and aging." Current Opinion in Immunology 25, no. 4 (2013): 516-522. Full Text
  - Kanda, J, Chiou, L-W, Szabolcs, P, Sempowski, GD, Rizzieri, DA, Long, GD, Sullivan, KM, Gasparetto, C, Chute, JP, Morris, A, McPherson, J, Hale, J, Livingston, JA, Broadwater, G, Niedzwiecki, D, Chao, NJ, and Horwitz, ME. "Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 18, no. 11 (November 2012): 1664-1676.e1. Full Text
  - Mendoza, AE, Neely, CJ, Charles, AG, Kartchner, LB, Brickey, WJ, Khoury, AL, Sempowski, GD, Ting, JPY, Cairns, BA, and Maile, R. "Radiation combined with thermal injury induces immature myeloid cells." Shock (Augusta, Ga.) 38, no. 5 (November 2012): 532-542. Full Text
  - Chinn, IK, Blackburn, CC, Manley, NR, and Sempowski, GD. "Changes in primary lymphoid organs with aging." Seminars in Immunology 24, no. 5 (October 2012): 309-320. (Review) Full Text
  - Gonzalez, RJ, Weening, EH, Frothingham, R, Sempowski, GD, and Miller, VL. "Bioluminescence imaging to track bacterial dissemination of Yersinia pestis using different routes of infection in mice." Bmc Microbiology 12 (July 24, 2012): 147-null. Full Text
  - Brickey, WJ, Neuringer, IP, Walton, W, Hua, X, Wang, EY, Jha, S, Sempowski, GD, Yang, X, Kirby, SL, Tilley, SL, and Ting, JP-Y. "MyD88 provides a protective role in long-term radiation-induced lung injury." International Journal of Radiation Biology 88, no. 4 (April 2012): 335-347. Full Text
  - Thompson, AL, Johnson, BT, Sempowski, GD, Gunn, MD, Hou, B, DeFranco, AL, and Staats, HF. "Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production." Journal of Immunology (Baltimore, Md. : 1950) 188, no. 6 (March 2012): 2834-2846. Full Text
  - Zhu, W, Ventevogel, MS, Knilans, KJ, Anderson, JE, Oldach, LM, McKinnon, KP, Hobbs, MM, Sempowski, GD, and Duncan, JA. "Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation." Plos One 7, no. 7 (January 2012): e41260-null. Full Text
  - Shi, X, Zhang, P, Sempowski, GD, and Shellito, JE. "Thymopoietic and bone marrow response to murine Pneumocystis pneumonia." Infection and Immunity 79, no. 5 (May 2011): 2031-2042. Full Text
  - Billard, MJ, Gruver, AL, and Sempowski, GD. "Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses." Plos One 6, no. 3 (March 18, 2011): e17940-null. Full Text
  - Jin, C, Shelburne, CP, Li, G, Potts, EN, Riebe, KJ, Sempowski, GD, Foster, WM, and Abraham, SN. "Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation." The Journal of Clinical Investigation 121, no. 3 (March 2011): 941-955. Full Text
  - Pastva, AM, Mukherjee, S, Giamberardino, C, Hsia, B, Lo, B, Sempowski, GD, and Wright, JR. "Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation." Journal of Immunology (Baltimore, Md. : 1950) 186, no. 5 (March 2011): 2842-2849. Full Text
  - Cain, DW, Snowden, PB, Sempowski, GD, and Kelsoe, G. "Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism." Plos One 6, no. 5 (January 2011): e19957-null. Full Text Open Access Copy
  - Gordy, C, Pua, H, Sempowski, GD, and He, Y-W. "Regulation of steady-state neutrophil homeostasis by macrophages." Blood 117, no. 2 (January 2011): 618-629. Full Text
  - Liu, C, Chen, BJ, Deoliveira, D, Sempowski, GD, Chao, NJ, and Storms, RW. "Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation." Blood 116, no. 25 (December 2010): 5518-5527. Full Text
  - Ahn, S-H, Deshmukh, H, Johnson, N, Cowell, LG, Rude, TH, Scott, WK, Nelson, CL, Zaas, AK, Marchuk, DA, Keum, S, Lamlertthon, S, Sharma-Kuinkel, BK, Sempowski, GD, and Fowler, VG. "Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses." Plos Pathogens 6, no. 9 (September 2, 2010): e1001088-null. Full Text Open Access Copy
  - Davis, CC, Marti, LC, Sempowski, GD, Jeyaraj, DA, and Szabolcs, P. "Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation." Cancer Research 70, no. 13 (July 2010): 5249-5258. Full Text
  - Chen, BJ, Deoliveira, D, Spasojevic, I, Sempowski, GD, Jiang, C, Owzar, K, Wang, X, Gesty-Palmer, D, Cline, JM, Bourland, JD, Dugan, G, Meadows, SK, Daher, P, Muramoto, G, Chute, JP, and Chao, NJ. "Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates." Plos One 5, no. 6 (June 16, 2010): e11056-null. Full Text Open Access Copy
  - Alderman, TS, Frothingham, R, and Sempowski, GD. "Validation of an Animal Isolation Imaging Chamber for Use in Animal Biosafety Level-3 Containment." Applied Biosafety : Journal of the American Biological Safety Association 15, no. 2 (January 2010): 62-66. Full Text
  - Na, I-K, Lu, SX, Yim, NL, Goldberg, GL, Tsai, J, Rao, U, Smith, OM, King, CG, Suh, D, Hirschhorn-Cymerman, D, Palomba, L, Penack, O, Holland, AM, Jenq, RR, Ghosh, A, Tran, H, Merghoub, T, Liu, C, Sempowski, GD, Ventevogel, M, Beauchemin, N, and van den Brink, MRM. "The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease." The Journal of Clinical Investigation 120, no. 1 (January 2010): 343-356. Full Text Open Access Copy
  - Gruver, AL, Ventevogel, MS, and Sempowski, GD. "Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution." The Journal of Endocrinology 203, no. 1 (October 2009): 75-85. Full Text
  - Sempowski, GD. "MODULATION OF THYMOPOIESIS ACROSS THE LIFESPAN." Gerontologist 49 (October 1, 2009): 346-346. Link to Item
  - Sarzotti-Kelsoe, M, Win, CM, Parrott, RE, Cooney, M, Moser, BK, Roberts, JL, Sempowski, GD, and Buckley, RH. "Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras." Blood 114, no. 7 (August 2009): 1445-1453. Full Text
  - Lynch, HE, Goldberg, GL, Chidgey, A, Van den Brink, MRM, Boyd, R, and Sempowski, GD. "Thymic involution and immune reconstitution." Trends in Immunology 30, no. 7 (July 2009): 366-373. (Review) Full Text
  - Gruver, AL, and Sempowski, GD. "Cytokines, leptin, and stress-induced thymic atrophy." Journal of Leukocyte Biology 84, no. 4 (October 2008): 915-923. (Review) Full Text
  - Page, KM, Mendizabal, AM, Prasad, VK, Martin, PL, Parikh, S, Wood, S, Sempowski, GD, Szabolcs, P, and Kurtzberg, J. "Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 14, no. 10 (October 2008): 1108-1117. Full Text
  - Gruver, AL, and Sempowski, GD. "Intrathymic Role for Leptin in the Prevention of Thymic Atrophy." Faseb Journal 22 (April 1, 2008). Link to Item
  - Howard, BA, Sempowski, GD, Scearce, RM, Liao, H-X, Lee, DM, Lam, GK, Chen, H, Fadden, P, Haystead, T, and Haynes, BF. "Murine CD7 shares antigenic cross-reactivity with HSP-60." Hybridoma (2005) 27, no. 2 (April 2008): 81-89. Full Text
  - Henry, SC, Daniell, X, Indaram, M, Whitesides, JF, Sempowski, GD, Howell, D, Oliver, T, and Taylor, GA. "Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47)." Journal of Immunology (Baltimore, Md. : 1950) 179, no. 10 (November 2007): 6963-6972. Full Text
  - Nordone, SK, Ignacio, GA, Su, L, Sempowski, GD, Golenbock, DT, Li, L, and Dean, GA. "Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation." Aids Research and Human Retroviruses 23, no. 11 (November 2007): 1387-1395. Full Text
  - Hudson, LL, Louise Markert, M, Devlin, BH, Haynes, BF, and Sempowski, GD. "Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection." Seminars in Immunology 19, no. 5 (October 2007): 297-309. (Review) Full Text
  - Gruver, AL, Hudson, LL, and Sempowski, GD. "Immunosenescence of ageing." The Journal of Pathology 211, no. 2 (January 2007): 144-156. (Review) Full Text
  - Li, F-Q, Sempowski, GD, McKenna, SE, Laskowitz, DT, Colton, CA, and Vitek, MP. "Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis." The Journal of Pharmacology and Experimental Therapeutics 318, no. 3 (September 2006): 956-965. Full Text
  - Hick, RW, Gruver, AL, Ventevogel, MS, Haynes, BF, and Sempowski, GD. "Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy." Journal of Immunology (Baltimore, Md. : 1950) 177, no. 1 (July 2006): 169-176. Full Text
  - Hart, JP, Broadwater, G, Rabbani, Z, Moeller, BJ, Clough, R, Huang, D, Sempowski, GA, Dewhirst, M, Pizzo, SV, Vujaskovic, Z, and Anscher, MS. "Cytokine profiling for prediction of symptomatic radiation-induced lung injury." International Journal of Radiation Oncology, Biology, Physics 63, no. 5 (December 2005): 1448-1454. Full Text
  - Sempowski, GD, Hicks, CB, Eron, JJ, Bartlett, JA, Hale, LP, Ferrari, G, Edwards, LJ, Fiscus, S, and Haynes, BF. "Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function." Journal of Clinical Immunology 25, no. 5 (September 2005): 462-472. Full Text
  - Lam, GK, Liao, H-X, Xue, Y, Alam, SM, Scearce, RM, Kaufman, RE, Sempowski, GD, and Haynes, BF. "Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma." Journal of Clinical Immunology 25, no. 1 (January 2005): 41-49. Full Text
  - Sempowski, GD, and Rhein, ME. "Measurement of mouse T cell receptor excision circles." Current Protocols in Immunology Chapter 10 (November 2004): Unit-10.31. (Review) Full Text
  - Markert, ML, Alexieff, MJ, Li, J, Sarzotti, M, Ozaki, DA, Devlin, BH, Sedlak, DA, Sempowski, GD, Hale, LP, Rice, HE, Mahaffey, SM, and Skinner, MA. "Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome." Blood 104, no. 8 (October 2004): 2574-2581. Full Text
  - Chen, BJ, Cui, X, Sempowski, GD, Domen, J, and Chao, NJ. "Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation." Blood 103, no. 11 (June 2004): 4344-4352. Full Text
  - Markert, ML, Alexieff, MJ, Li, J, Sarzotti, M, Ozaki, DA, Devlin, BH, Sempowski, GD, Rhein, ME, Szabolcs, P, Hale, LP, Buckley, RH, Coyne, KE, Rice, HE, Mahaffey, SM, and Skinner, MA. "Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases." The Journal of Allergy and Clinical Immunology 113, no. 4 (April 2004): 734-741. Full Text
  - Chen, BJ, Cui, X, Sempowski, GD, Liu, C, and Chao, NJ. "Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease." Blood 103, no. 4 (February 2004): 1534-1541. Full Text
  - Sempowski, GD, Cross, SJ, Heinly, CS, Scearce, RM, and Haynes, BF. "CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis." Journal of Immunology (Baltimore, Md. : 1950) 172, no. 2 (January 2004): 787-794. Full Text
  - Sempowski, GD, and Rhein, ME. "Measurement of mouse T cell receptor excision circles." Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.] Chapter 10 (January 1, 2004). (Review)
  - Chen, BJ, Cui, X, Sempowski, GD, and Chao, NJ. "Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice." Experimental Hematology 31, no. 10 (October 2003): 953-958. Full Text
  - Markert, ML, Sarzotti, M, Ozaki, DA, Sempowski, GD, Rhein, ME, Hale, LP, Le Deist, F, Alexieff, MJ, Li, J, Hauser, ER, Haynes, BF, Rice, HE, Skinner, MA, Mahaffey, SM, Jaggers, J, Stein, LD, and Mill, MR. "Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients." Blood 102, no. 3 (August 2003): 1121-1130. Full Text
  - Ohm, JE, Gabrilovich, DI, Sempowski, GD, Kisseleva, E, Parman, KS, Nadaf, S, and Carbone, DP. "VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression." Blood 101, no. 12 (June 2003): 4878-4886. Full Text
  - Sufka, SA, Ferrari, G, Gryszowka, VE, Wrin, T, Fiscus, SA, Tomaras, GD, Staats, HF, Patel, DD, Sempowski, GD, Hellmann, NS, Weinhold, KJ, and Hicks, CB. "Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control." The Journal of Infectious Diseases 187, no. 7 (April 2003): 1027-1037. Full Text
  - Min, B, McHugh, R, Sempowski, GD, Mackall, C, Foucras, G, and Paul, WE. "Neonates support lymphopenia-induced proliferation." Immunity 18, no. 1 (January 2003): 131-140. Full Text
  - Sempowski, GD, Rhein, ME, Scearce, RM, and Haynes, BF. "Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy." European Journal of Immunology 32, no. 11 (November 2002): 3066-3070. Full Text
  - Hale, LP, Greer, PK, and Sempowski, GD. "Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation." Clinical Immunology (Orlando, Fla.) 104, no. 2 (August 2002): 183-190. Full Text
  - Markert, ML, Sarzotti, M, Ozaki, DA, Sempowski, GD, Rhein, ME, Hale, LP, Alexieff, MA, and Li, J. "Thymic transplantation in complete DiGeorge syndrome." Clinical Immunology 103, no. 3 (June 1, 2002): S77-S78. Link to Item
  - Haynes, BF, and Sempowski, GD. "Protection from death in endotoxin shock: does fish oil need a LIF?." Critical Care Medicine 30, no. 5 (May 2002): 1174-1175. Full Text
  - Gooding, ME, Sempowski, GD, and Haynes, BF. "The thymus is the predominant site of T cell rearrangement in early human T cell development." Faseb Journal 16, no. 4 (March 20, 2002): A346-A346. Link to Item
  - Sempowski, GD, Heinly, CS, Lee, DM, Scearce, RM, and Haynes, BF. "CD7 and CD28 play a critical role in the development of CD4 T regulatory cells." Faseb Journal 16, no. 4 (March 20, 2002): A342-A342. Link to Item
  - Sempowski, GD, Gooding, ME, Liao, HX, Le, PT, and Haynes, BF. "T cell receptor excision circle assessment of thymopoiesis in aging mice." Molecular Immunology 38, no. 11 (March 2002): 841-848. Full Text
  - Bradney, CP, Sempowski, GD, Liao, H-X, Haynes, BF, and Staats, HF. "Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization." Journal of Virology 76, no. 2 (January 2002): 517-524. Full Text
  - Chen, BJ, Cui, X, Sempowski, GD, Gooding, ME, Liu, C, Haynes, BF, and Chao, NJ. "A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution." Blood 99, no. 1 (January 2002): 364-371. Full Text
  - Min, B, Sempowski, GD, and Paul, WE. "Neonates support "homeostatic" proliferation." Advances in Experimental Medicine and Biology 512 (January 2002): 91-95.
  - Sempowski, GD, Gooding, ME, Le, PT, and Haynes, BF. "Erratum: Corrigendum to "T Cell receptor excision circle assessment of thymopoieses in aging mice" (MIMM (2001) 38: 11 (841-848) PII S0161589001001225)." Molecular Immunology 39, no. 5-6 (January 1, 2002): 379-380. Full Text
  - Sempowski, GD, and Haynes, BF. "Immune reconstitution in patients with HIV infection." Annual Review of Medicine 53 (January 2002): 269-284. (Review) Full Text
  - Smith, TJ, Koumas, L, Gagnon, A, Bell, A, Sempowski, GD, Phipps, RP, and Sorisky, A. "Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy." The Journal of Clinical Endocrinology and Metabolism 87, no. 1 (January 2002): 385-392. Full Text
  - Markert, ML, Alvarez-McLeod, AP, Sempowski, GD, Hale, LP, Horvatinovich, JM, Weinhold, KJ, Bartlett, JA, D'Amico, TA, and Haynes, BF. "Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy." Aids Research and Human Retroviruses 17, no. 17 (November 2001): 1635-1643. Full Text
  - Staats, HF, Bradney, CP, Gwinn, WM, Jackson, SS, Sempowski, GD, Liao, HX, Letvin, NL, and Haynes, BF. "Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization." Journal of Immunology (Baltimore, Md. : 1950) 167, no. 9 (November 2001): 5386-5394. Full Text
  - Smith, CC, Sempowski, GD, and Rockey, DC. "Increased hepatic fibrosis in very young mice is associated with induction of liver natural killer cells." Hepatology 34, no. 4 (October 1, 2001): 394A-394A. Link to Item
  - Collazo, CM, Yap, GS, Sempowski, GD, Lusby, KC, Tessarollo, L, Vande Woude, GF, Sher, A, and Taylor, GA. "Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection." The Journal of Experimental Medicine 194, no. 2 (July 2001): 181-188. Full Text
  - Haynes, BF, and Sempowski, GD. "Can the thymus win the battle against drug-resistant HIV?." Nature Medicine 7, no. 6 (June 2001): 661-662. Full Text
  - Lam, GK, Liao, HX, Xue, Y, Alam, SM, Thomasch, JR, Sempowski, GD, Stauffer, SH, Kaufman, R, and Haynes, BF. "Characterisation and expression of CD7 ligand, K-12, in human thymic epithelial cells." Faseb Journal 15, no. 5 (March 8, 2001): A1033-A1033. Link to Item
  - Sempowski, GD, Gooding, ME, Scearce, RM, and Haynes, BF. "Role of leukemia inhibitory factor and corticosteroids in the pathogenesis of lipopolysaccharride-induced acute thymic atrophy." Faseb Journal 15, no. 5 (March 8, 2001): A1057-A1057. Link to Item
  - Sempowski, GD, Gooding, ME, Le, PT, Liao, HX, and Haynes, BF. "Molecular characterization of thymic output in aging mice using signal joint T cell receptor delta excision circles." Faseb Journal 15, no. 4 (March 7, 2001): A667-A667. Link to Item
  - Heinly, CS, Sempowski, GD, Lee, DM, Patel, DD, McDermott, PM, Scearce, RM, Thompson, CB, and Haynes, BF. "Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice." International Immunology 13, no. 2 (February 2001): 157-166. Full Text
  - Sempowski, G, Thomasch, J, Gooding, M, Hale, L, Edwards, L, Ciafaloni, E, Sanders, D, Massey, J, Douek, D, Koup, R, and Haynes, B. "Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis." Journal of Immunology (Baltimore, Md. : 1950) 166, no. 4 (February 2001): 2808-2817. Full Text
  - Klein, AK, Patel, DD, Gooding, ME, Sempowski, GD, Chen, BJ, Liu, C, Kurtzberg, J, Haynes, BF, and Chao, NJ. "T-Cell recovery in adults and children following umbilical cord blood transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 7, no. 8 (January 2001): 454-466. Full Text
  - Sempowski, GD, Hale, LP, Sundy, JS, Massey, JM, Koup, RA, Douek, DC, Patel, DD, and Haynes, BF. "Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy." Journal of Immunology (Baltimore, Md. : 1950) 164, no. 4 (February 2000): 2180-2187. Full Text
  - Haynes, BF, Markert, ML, Sempowski, GD, Patel, DD, and Hale, LP. "The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection." Annual Review of Immunology 18 (January 2000): 529-560. (Review) Full Text
  - Haynes, BF, Sempowski, GD, Wells, AF, and Hale, LP. "The human thymus during aging." Immunologic Research 22, no. 2-3 (January 2000): 253-261. (Review) Full Text
  - SEMPOWSKI, G. "Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy." J. Immunol. 164 (2000).
  - Flores, KG, Li, J, Sempowski, GD, Haynes, BF, and Hale, LP. "Analysis of the human thymic perivascular space during aging." The Journal of Clinical Investigation 104, no. 8 (October 1999): 1031-1039. Full Text
  - Sempowski, GD, Lee, DM, Scearce, RM, Patel, DD, and Haynes, BF. "Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes." The Journal of Experimental Medicine 189, no. 6 (March 1999): 1011-1016. Full Text
  - Sempowski, GD, Lee, DM, Kaufman, RE, and Haynes, BF. "Structure and function of the CD7 molecule." Critical Reviews in Immunology 19, no. 4 (January 1999): 331-348. (Review)
  - Lee, DM, Staats, HF, Sundy, JS, Patel, DD, Sempowski, GD, Scearce, RM, Jones, DM, and Haynes, BF. "Immunologic characterization of CD7-deficient mice." Journal of Immunology (Baltimore, Md. : 1950) 160, no. 12 (June 1998): 5749-5756.
  - Sempowski, GD, Rozenblit, J, Smith, TJ, and Phipps, RP. "Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production." The American Journal of Physiology 274, no. 3 (March 1998): C707-C714. Full Text
  - Sempowski, GD, Rozenblit, J, Smith, TJ, and Phipps, RP. "Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production." American Journal of Physiology Cell Physiology 274, no. 3 43-3 (March 1, 1998).
  - Sempowski, GD, Rozenblit, J, Smith, TJ, and Phipps, RP. "Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production." American Journal of Physiology Cell Physiology 274, no. 3 (March 1, 1998): C707-C714. (Academic Article) Link to Item
  - Smith, TJ, Sempowski, GD, Berenson, CS, Cao, HJ, Wang, HS, and Phipps, RP. "Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression." Endocrinology 138, no. 12 (December 1997): 5576-5588. Full Text
  - Sempowski, GD, Chess, PR, and Phipps, RP. "CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts." Journal of Immunology (Baltimore, Md. : 1950) 158, no. 10 (May 1997): 4670-4677.
  - Sempowski, GD, Chess, PR, Moretti, AJ, Padilla, J, Phipps, RP, and Blieden, TM. "CD40 mediated activation of gingival and periodontal ligament fibroblasts." Journal of Periodontology 68, no. 3 (March 1997): 284-292. Full Text
  - Blieden, TM, Sempowski, GD, Padilla, J, Suchkova, VN, Chess, P, and Phipps, RP. "Periodontal fibroblast activation via CD40." Journal of Dental Research 76 (January 1, 1997): 1297-1297. Link to Item
  - Padilla, J, Sempowski, GD, Suchkova, VN, Blieden, TM, and Phipps, RP. "Expression and significance of CD40 on human gingival tissue." Journal of Dental Research 76 (January 1, 1997): 3423-3423. Link to Item
  - SEMPOWSKI, G. "CD40 mediated activation of gingival and periodontal ligament fibroblasts." J Periodontol 68 (1997): 284-292.
  - Gaspari, AA, Sempowski, GD, Chess, P, Gish, J, and Phipps, RP. "Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism." European Journal of Immunology 26, no. 6 (June 1996): 1371-1377. Full Text
  - Sempowski, GD, Derdak, S, and Phipps, RP. "Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets." Journal of Cellular Physiology 167, no. 2 (May 1996): 290-296. Full Text
  - Sempowski, GD, Gaspari, T, Chess, P, and Phipps, RP. "Functional expression of CD40 on human lung fibroblasts and its role in fibroblast activation and interaction with T lymphocytes and mast cells." Faseb Journal 10, no. 6 (April 30, 1996): 1904-1904. Link to Item
  - Gaspari, AA, Sempowski, GD, Chess, PR, Gish, J, and Phipps, RP. "Cultured human keratinocytes express functional CD40 that mediates protein tyrosine kinase-dependent transmembrane signals and costimulates resting T-lymphocyte proliferation." Journal of Investigative Dermatology 106, no. 4 (April 1, 1996): 712-712. Link to Item
  - Blieden, TM, Sempowski, GD, Padilla, J, and Phipps, RP. "The role of CD40 expression by peridontal fibroblasts." Journal of Dental Research 75 (January 1, 1996): 96-96. Link to Item
  - Fries, KM, Sempowski, GD, Gaspari, AA, Blieden, T, Looney, RJ, and Phipps, RP. "CD40 expression by human fibroblasts." Clinical Immunology and Immunopathology 77, no. 1 (October 1995): 42-51. Full Text
  - Smith, TJ, Sempowski, GD, Wang, HS, Del Vecchio, PJ, Lippe, SD, and Phipps, RP. "Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts." The Journal of Clinical Endocrinology and Metabolism 80, no. 9 (September 1995): 2620-2625. Full Text
  - GASPARI, AA, FRIES, K, SEMPOWSKI, GD, and PHIPPS, RP. "HUMAN KERATINOCYTES CONSTITUTIVELY EXPRESS CD40, A COSTIMULATORY LIGAND FOR ACTIVATED T-LYMPHOCYTES." Journal of Investigative Dermatology 104, no. 4 (April 1, 1995): 570-570. Link to Item
  - Sempowski, GD, Borrello, MA, Blieden, TM, Barth, RK, and Phipps, RP. "Fibroblast heterogeneity in the healing wound." Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society 3, no. 2 (April 1995): 120-131. Full Text
  - SEMPOWSKI, G. "Fibroblast heterogeneity in the healing wound." Wound Rep Reg 3 (1995). Full Text
  - Silvera, MR, Sempowski, GD, and Phipps, RP. "Expression of TGF-beta isoforms by Thy-1+ and Thy-1- pulmonary fibroblast subsets: evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6." Lymphokine and Cytokine Research 13, no. 5 (October 1994): 277-285.
  - Fries, KM, Blieden, T, Looney, RJ, Sempowski, GD, Silvera, MR, Willis, RA, and Phipps, RP. "Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis." Clinical Immunology and Immunopathology 72, no. 3 (September 1994): 283-292. (Review) Full Text
  - Sempowski, GD, Beckmann, MP, Derdak, S, and Phipps, RP. "Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis." Journal of Immunology (Baltimore, Md. : 1950) 152, no. 7 (April 1994): 3606-3614.
  - Silvera, MR, Sempowski, GD, Phipps, RP, Penney, DP, and Watts, H. "Lung Fibroblast Heterogeneity." Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung 6, no. 1 (January 1, 1993): 1-21. Full Text
  - Li, P, Thaw, CN, Sempowski, GD, Gershengorn, MC, and Hinkle, PM. "Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels." Molecular Endocrinology (Baltimore, Md.) 6, no. 9 (September 1992): 1393-1402. Full Text
- Conference Papers
  - Hayashi, T, Lynch, HE, Geyer, S, Yoshida, K, Furudoi, K, Sasaki, K, Morishita, Y, Nagamura, H, Maki, M, Hu, Y, Hayashi, I, Kyoizumi, S, Kusunoki, Y, Ohishi, W, Fujiwara, S, Misumi, M, Shterev, I, Nikolich-Žugich, J, Murasko, D, Hale, LP, Sempowski, GD, and Nakachi, K. "Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort." October 2018. Full Text
  - Lee, DE, Zhong, W, Dong, L, Russell, AR, O'Connell, C, Wiesenfeld, H, Hillier, S, Sempowski, GD, Zheng, X, and Darville, T. "Increased levels of Th1-inducing cytokines are detected in cervical secretions of women with Chlamydia trachomatis infection limited to their cervix." Annual Meeting of the American-Association-of-Immunologists (AAI). Austin, TX. May 4, 2018 - May 8, 2018.: AMER ASSOC IMMUNOLOGISTS, May 1, 2018. Link to Item
  - Junkins, RD, Gallovic, MD, Johnson, BM, Collier, MA, Watkins-Schulz, R, Cheng, N, David, CN, McGee, CE, Sempowski, GD, Shterev, I, McKinnon, K, Bachelder, EM, Ainslie, KM, and Ting, JP-Y. "A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination." January 2018. Full Text
  - Kajimura, J, Lynch, HE, Geyer, S, Yamaoka, M, Shterev, I, Kyoizumi, S, Sempowski, GD, Nakachi, K, and Kusunoki, Y. "Effect of past radiation exposure on the circulating dendritic cell populations in A-bomb survivors." International Congress of Immunology (ICI). Melbourne, AUSTRALIA. August 21, 2016 - August 26, 2016.: WILEY-BLACKWELL, August 1, 2016. Link to Item
  - Yeh, C-H, Kuraoka, M, Lynch, H, Sempowski, GD, and Kelsoe, GH. "TCR Repertoire Analysis of Mouse T Follicular Helper Cells and T Follicular Regulatory Cells Following Immunization." Annual Meeting of the American-Association-of-Immunologists (AAI). Seattle, WA. May 13, 2016 - May 17, 2016.: AMER ASSOC IMMUNOLOGISTS, May 1, 2016. Link to Item
  - Bowles, RD, Karikari, IO, Riebe, KJ, Sempowski, GD, and Setton, LA. "In vivo imaging of NF-кB activity and correlation to pain in a model of radiculopathy." : Elsevier BV, April 2013. Full Text
  - Lunsford, KE, Jackson-Baird, B, Sempowski, GD, Cardona, DM, Weinhold, KJ, and Brennan, TV. "Novel Murine Model of Pancreatic Ischemia Reperfusion Injury Up-Regulates Interleukin-1 Beta, Interleukin-6, and CCL-2." American Transplant Congress. Boston, MA. May 2012.: WILEY-BLACKWELL, May 1, 2012. Link to Item
  - Lunsford, KE, Jackson-Baird, B, Sempowski, GD, Cardona, DM, and Brennan, TV. "Murine Pancreatic Ischemia-Reperfusion Injury Up-Regulates Interleukin-1 beta, Interleukin-6, and CCL-2." American-Society-of-Transplant-Surgeons (ASTS) 12th Annual State of the Art Winter Symposium/North-American-Transplant-Coordinators-Organization (NATCO) Symposium for Advanced Transplant Professionals. Miami, FL. January 12, 2012 - January 15, 2012.: WILEY-BLACKWELL, January 1, 2012. Link to Item
  - Gruver, AL, and Sempowski, GD. "Leptin protects against endotoxin-induced thymic remodeling." : AMER ASSOC IMMUNOLOGISTS, April 1, 2009. Link to Item
  - Liu, C, DeOliveira, D, Sempowski, GD, Chao, NJ, Chen, BJ, and Storms, RW. "Complete Long-Term Hematopoietic Engraftment by Lineage-Depleted ALDH CD34+ UCB Cells." : Elsevier BV, February 2009. Full Text
  - Gruver, AL, Ventevogel, MS, and Sempowski, GD. "Leptin Directly Protects Thymus Tissue from Endotoxin-induced Involution." : AMER ASSOC IMMUNOLOGISTS, April 1, 2007. Link to Item
  - Kendall, SM, Ventevogel, MS, and Sempowski, GD. "Thymopoiesis is Enhanced by Inhibition of gp130 Signaling in Young and Aged Mice." : AMER ASSOC IMMUNOLOGISTS, April 1, 2007. Link to Item
  - Gruver, AL, Ventevogel, MS, Haynes, BF, and Sempowski, GD. "Leptin selectively augments thymopoiesis in LPS-induced thymic atrophy." Annual Meeting of the American-Association-of-Immunologists. Boston, MA. May 12, 2006 - May 16, 2006.: AMER ASSOC IMMUNOLOGISTS, April 1, 2006. Link to Item
  - Peacock, JW, Ventevogel, M, Haynes, BF, and Sempowski, GD. "Toll like receptor agonist induction of thymic CD4+, CD25+T regulatory cells during vaccination." Annual Meeting of the American-Association-of-Immunologists. Boston, MA. May 12, 2006 - May 16, 2006.: AMER ASSOC IMMUNOLOGISTS, April 1, 2006. Link to Item
  - Sempowski, GD, Cross, SJ, Heinly, CS, Scearce, RM, and Haynes, BF. "CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis." Experimental Biology 2004 Meeting. Washington, DC. April 17, 2004 - April 21, 2004.: FEDERATION AMER SOC EXP BIOL, March 24, 2004. Link to Item
  - Chen, BJ, Cui, XY, Sempowski, GD, Domen, J, and Chao, N. "Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation." 45th Annual Meeting of the American-Society-of-Hematology. SAN DIEGO, CALIFORNIA. December 6, 2003 - December 9, 2003.: AMER SOC HEMATOLOGY, November 16, 2003. Link to Item
  - Cross, SJ, Sempowski, GD, and Haynes, BF. "Immunophenotypic and functional characterization of CD4+ CD25+ regulatory T cells as a function of aging in normal human peripheral blood and autoimmune disease." 44th Annual Meeting of the American-Society-of-Hematology. PHILADELPHIA, PENNSYLVANIA. December 6, 2002 - December 10, 2002.: AMER SOC HEMATOLOGY, November 16, 2002. Link to Item
  - Sempowski, GD, Hicks, C, Edwards, L, Ferrari, G, Eron, J, and Haynes, BF. "Naive T cells are maintained in the periphery during acute HIV infection." : FEDERATION AMER SOC EXP BIOL, March 20, 2002. Link to Item
Teaching & Mentoring
Recent Courses
- PATHOL 293: Research Independent Study 2019
- PATHOL 793: Research Independent Study 2019

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Education, Training, & Certifications

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Recent Courses