Gregory Alan Taylor
Professor in Medicine
My lab uses mouse genetic modeling and molecular and cellular techniques to study basic biochemical pathways of relevance to aging biology.
I. Aging is often accompanied by increases in inflammation. A major interest of the lab is how perturbations in the regulation of autophagy and mitochondrial dynamics in cells are linked to inflammation. One project in the lab focuses on a family of interferon-gamma and LPS regulated proteins, the Immunity Related GTPases (IRGs). The lab has shown that mice and cells lacking one of these proteins, Irgm1, have excessive inflammatory responses that are accompanied by decreases in autophagy and mitophagy, and altered cellular metabolism. IRG genes in human (IRGM) have been linked to several inflammatory diseases including Crohn’s disease and sepsis. Current work in the lab focuses on their role in those diseases using bacterial and relevant mouse models.
II. Altered expression of the cytokine Transforming Growth Factor beta (TGF-b) has been linked with a number of aging processes, including stem cell and neural function. TGF-b is consequently a therapeutic target for a number of age-related diseases. The lab is studying a novel regulator of TGF-b expression called P311, which drives TGF-b translation. Mice have been created that lack P311 and are being used to address the role of P311 in a number of physiological processes.
Current Appointments & Affiliations
- Professor in Medicine, Medicine, Geriatrics, Medicine 2021
- Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2008
- Associate Research Professor in Immunology, Integrative Immunobiology, Basic Science Departments 2020
- Senior Fellow of the Center for the Study of Aging and Human Development, Center for the Study of Aging and Human Development, Institutes and Centers 2020
Contact Information
- 182 Grecc VA Med Ctr, 508 Fulton St, Durham, NC 27705
- Duke Box 3003, Durham, NC 27710
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gregory.taylor@duke.edu
(919) 286-0411
- Background
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Education, Training, & Certifications
- Ph.D., Duke University 1995
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Previous Appointments & Affiliations
- Professor in Medicine, Medicine, Geriatrics, Medicine 2020
- Assistant Research Professor in Immunology, Integrative Immunobiology, Basic Science Departments 2000 - 2020
- Associate Professor in Medicine, Medicine, Geriatrics, Medicine 2008 - 2020
- Assistant Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2005 - 2008
- Assistant Professor in Medicine, Medicine, Geriatrics, Medicine 2006 - 2008
- Assistant Research Professor in Medicine, Medicine, Geriatrics, Medicine 1999 - 2006
- Instructor, Temporary in the Department of Medicine, Medicine, Geriatrics, Medicine 1999
- Expertise
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Subject Headings
- 3T3 Cells
- Acetylcysteine
- Actins
- Adolescent
- Adult
- Aged
- Amino Acid Motifs
- Amino Acid Sequence
- Antibodies, Monoclonal
- Apoptosis Regulatory Proteins
- Autoantibodies
- Autophagy
- Bacterial Infections
- Brefeldin A
- CD4-Positive T-Lymphocytes
- Cachexia
- Carnitine
- Cells, Cultured
- Child
- Chlamydia
- Chlamydia Infections
- Chlamydia muridarum
- Chlamydia trachomatis
- Chromosomes, Human, Pair 19
- Cloning, Molecular
- Collagen
- Computational Biology
- Cyclopentanes
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Cytokines
- Cytoskeleton
- Cytosol
- DNA Primers
- Diagnostic Imaging
- Disease Susceptibility
- Endoplasmic Reticulum
- Enzyme Induction
- Epithelial Cells
- Female
- Fibroblasts
- Flavonols
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Gait
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Gene Targeting
- Genetic Predisposition to Disease
- Green Fluorescent Proteins
- Growth Substances
- Guanosine Triphosphate
- Hand Strength
- Hepatocyte Growth Factor
- Host-Pathogen Interactions
- Humans
- Hydro-Lyases
- Image Interpretation, Computer-Assisted
- Immunity
- Immunity, Innate
- Infant
- Infection
- Inflammation
- Inflammation Mediators
- Interferon Type I
- Interferon-gamma
- Interferons
- Ligands
- Listeria monocytogenes
- Listeriosis
- Lysosomes
- Macrophage Activation
- Macrophages
- Macrophages, Alveolar
- Macrophages, Peritoneal
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Mutant Strains
- Mice, Transgenic
- Microscopy, Electron, Transmission
- Microscopy, Fluorescence
- Microscopy, Immunoelectron
- Microtubule-Associated Proteins
- Models, Biological
- Molecular Sequence Data
- Muromegalovirus
- Mutagenesis, Insertional
- Mutagenesis, Site-Directed
- Mycobacterium avium
- Mycobacterium bovis
- Mycobacterium tuberculosis
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Oligopeptides
- Oncogene Proteins
- Overweight
- Paneth Cells
- Paxillin
- Phagosomes
- Phosphatidylinositol 3-Kinases
- Phospholipases A2
- Polymerase Chain Reaction
- Proline-Rich Protein Domains
- Proteasome Endopeptidase Complex
- Protein Synthesis Inhibitors
- Proteins
- Proto-Oncogene Proteins c-met
- Protozoan Infections
- RNA, Messenger
- RNA, Small Interfering
- Radiology
- Rats
- Receptor Protein-Tyrosine Kinases
- Recombinant Fusion Proteins
- Reverse Transcriptase Polymerase Chain Reaction
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Salmonella Infections, Animal
- Sequence Deletion
- Sirolimus
- Syndrome
- T-Lymphocytes
- Tetradecanoylphorbol Acetate
- Toxoplasma
- Toxoplasmosis, Animal
- Toxoplasmosis, Cerebral
- Transfection
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Tristetraprolin
- Tuberculosis
- Tumor Necrosis Factor-alpha
- Ubiquitin
- Vacuoles
- Veterans
- Zinc Fingers
- rac GTP-Binding Proteins
- ras Proteins
- Research
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Selected Grants
- Behavior and Physiology in Aging awarded by National Institutes of Health 2015 - 2025
- IRGM proteins as regulators of inflammation awarded by National Institutes of Health 2020 - 2025
- Role of IRGM proteins in immunity to enteric bacteria awarded by National Institutes of Health 2019 - 2024
- Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy awarded by Department of Defense 2020 - 2023
- Regulation of T cell metabolism and function by IRGM proteins awarded by National Institutes of Health 2019 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Seahorse XFe96 Extracellular Flux Analyzer awarded by North Carolina Biotechnology Center 2017 - 2018
- Regulation of Host Defense by IRG Proteins awarded by National Institutes of Health 2004 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Bourassa, Kyle J., Avshalom Caspi, Grace M. Brennan, Katherine S. Hall, HonaLee Harrington, Renate Houts, Nathan A. Kimbrel, et al. “Which Types of Stress Are Associated With Accelerated Biological Aging? Comparing Perceived Stress, Stressful Life Events, Childhood Adversity, and Posttraumatic Stress Disorder.” Psychosom Med 85, no. 5 (June 1, 2023): 389–96. https://doi.org/10.1097/PSY.0000000000001197.Full Text Link to Item
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Singh, Shishir, Mateo Murillo-León, Niklas Sebastian Endres, Ailan Farid Arenas Soto, Jorge Enrique Gómez-Marín, Florence Melbert, Thirumala-Devi Kanneganti, et al. “ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence.” Plos Pathog 19, no. 1 (January 2023): e1011003. https://doi.org/10.1371/journal.ppat.1011003.Full Text Link to Item
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Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.Full Text Link to Item
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Gullicksrud, Jodi A., Adam Sateriale, Julie B. Engiles, Alexis R. Gibson, Sebastian Shaw, Zachary A. Hutchins, Lindsay Martin, et al. “Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium.” Mucosal Immunol 15, no. 2 (February 2022): 362–72. https://doi.org/10.1038/s41385-021-00468-6.Full Text Link to Item
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Alwarawrah, Yazan, Keiko Danzaki, Amanda G. Nichols, Brian E. Fee, Cheryl Bock, Gary Kucera, Laura P. Hale, Gregory A. Taylor, and Nancie J. MacIver. “Irgm1 regulates metabolism and function in T cell subsets.” Sci Rep 12, no. 1 (January 17, 2022): 850. https://doi.org/10.1038/s41598-021-04442-x.Full Text Link to Item
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Dockterman, Jacob, Brian E. Fee, Gregory A. Taylor, and Jörn Coers. “Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii.” Infect Immun 89, no. 11 (October 15, 2021): e0020221. https://doi.org/10.1128/IAI.00202-21.Full Text Link to Item
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Rai, Prashant, Kyathanahalli S. Janardhan, Julie Meacham, Jennifer H. Madenspacher, Wan-Chi Lin, Peer W. F. Karmaus, Jennifer Martinez, et al. “IRGM1 links mitochondrial quality control to autoimmunity.” Nat Immunol 22, no. 3 (March 2021): 312–21. https://doi.org/10.1038/s41590-020-00859-0.Full Text Link to Item
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Finethy, Ryan, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham D. Wallace, Anthony S. Piro, Sarah Luoma, et al. “Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.” Embo Rep 21, no. 11 (November 5, 2020): e50830. https://doi.org/10.15252/embr.202050830.Full Text Link to Item
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Norona, Johana, Petya Apostolova, Dominik Schmidt, Rebekka Ihlemann, Nadine Reischmann, Gregory Taylor, Natalie Köhler, et al. “Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.” Blood 136, no. 12 (September 17, 2020): 1442–55. https://doi.org/10.1182/blood.2020005957.Full Text Link to Item
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Kongsomboonvech, Angel K., Felipe Rodriguez, Anh L. Diep, Brandon M. Justice, Brayan E. Castallanos, Ana Camejo, Debanjan Mukhopadhyay, et al. “Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.” Plos Pathog 16, no. 8 (August 2020): e1008327. https://doi.org/10.1371/journal.ppat.1008327.Full Text Link to Item
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Taylor, Gregory A., Hsin-I Huang, Brian E. Fee, Nourhan Youssef, Mark L. Jewell, Viviana Cantillana, Alexi A. Schoenborn, et al. “Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.” Plos Pathog 16, no. 5 (May 2020): e1008553. https://doi.org/10.1371/journal.ppat.1008553.Full Text Link to Item
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Finethy, Ryan, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham Wallace, Anthony Piro, Sarah Luoma, et al. “Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock,” 2020. https://doi.org/10.1101/2020.03.18.997460.Full Text Open Access Copy
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Fox, Barbara A., Rebekah B. Guevara, Leah M. Rommereim, Alejandra Falla, Valeria Bellini, Graciane Pètre, Camille Rak, et al. “Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon.” Mbio 10, no. 4 (July 2, 2019). https://doi.org/10.1128/mBio.00589-19.Full Text Link to Item
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Mehto, Subhash, Kautilya Kumar Jena, Parej Nath, Swati Chauhan, Srinivasa Prasad Kolapalli, Saroj Kumar Das, Pradyumna Kumar Sahoo, Ashish Jain, Gregory A. Taylor, and Santosh Chauhan. “The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.” Mol Cell 73, no. 3 (February 7, 2019): 429-445.e7. https://doi.org/10.1016/j.molcel.2018.11.018.Full Text Link to Item
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Rommereim, Leah M., Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, and David J. Bzik. “Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells.” Front Immunol 10 (2019): 2104. https://doi.org/10.3389/fimmu.2019.02104.Full Text Link to Item
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Coers, Jörn, Hailey M. Brown, Seungmin Hwang, and Gregory A. Taylor. “Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense.” Curr Opin Immunol 54 (October 2018): 93–101. https://doi.org/10.1016/j.coi.2018.06.008.Full Text Link to Item
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Rogala, Allison R., Alexi A. Schoenborn, Brian E. Fee, Viviana A. Cantillana, Maria J. Joyce, Raad Z. Gharaibeh, Sayanty Roy, et al. “Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice.” Dis Model Mech 11, no. 2 (February 7, 2018). https://doi.org/10.1242/dmm.031070.Full Text Link to Item
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Azzam, Kathleen M., Jennifer H. Madenspacher, Derek W. Cain, Lihua Lai, Kymberly M. Gowdy, Prashant Rai, Kyathanahalli Janardhan, et al. “Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.” Jci Insight 2, no. 16 (August 17, 2017). https://doi.org/10.1172/jci.insight.91914.Full Text Link to Item
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Biering, Scott B., Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, et al. “Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.” Cell Host Microbe 22, no. 1 (July 12, 2017): 74-85.e7. https://doi.org/10.1016/j.chom.2017.06.005.Full Text Link to Item
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Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.Full Text Link to Item
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Greer, Renee L., Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, et al. “Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.” Nat Commun 7 (November 14, 2016): 13329. https://doi.org/10.1038/ncomms13329.Full Text Link to Item
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Lin, Xingguang, Jialong Yang, Jinli Wang, Hongxiang Huang, Hong-Xia Wang, Pengcheng Chen, Shang Wang, et al. “mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.” Sci Rep 6 (October 12, 2016): 34939. https://doi.org/10.1038/srep34939.Full Text Link to Item
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Pilla-Moffett, Danielle, Matthew F. Barber, Gregory A. Taylor, and Jörn Coers. “Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.” J Mol Biol 428, no. 17 (August 28, 2016): 3495–3513. https://doi.org/10.1016/j.jmb.2016.04.032.Full Text Link to Item
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“Erratum.” Autophagy 12, no. 2 (2016): 443. https://doi.org/10.1080/15548627.2016.1147886.Full Text Link to Item
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Murray, Henry W., Marisa Mitchell-Flack, Gregory A. Taylor, and Xiaojing Ma. “IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.” Exp Parasitol 157 (October 2015): 103–9. https://doi.org/10.1016/j.exppara.2015.07.005.Full Text Link to Item
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Guo, Jintao, James A. McQuillan, Belinda Yau, Gregory S. Tullo, Carole A. Long, Patrick Bertolino, Ben Roediger, et al. “IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.” Infect Immun 83, no. 4 (April 2015): 1406–17. https://doi.org/10.1128/IAI.02701-14.Full Text Link to Item
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Henry, Stanley C., Elyse A. Schmidt, Michael B. Fessler, and Gregory A. Taylor. “Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.” Plos One 9, no. 4 (2014): e95021. https://doi.org/10.1371/journal.pone.0095021.Full Text Link to Item
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Liu, Bo, Ajay S. Gulati, Viviana Cantillana, Stanley C. Henry, Elyse A. Schmidt, Xiaoju Daniell, Emily Grossniklaus, Alexi A. Schoenborn, R Balfour Sartor, and Gregory A. Taylor. “Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.” Am J Physiol Gastrointest Liver Physiol 305, no. 8 (October 15, 2013): G573–84. https://doi.org/10.1152/ajpgi.00071.2013.Full Text Link to Item
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Badri, Kameswara Rao, Ming Yue, Oscar A. Carretero, Sree Latha Aramgam, Jun Cao, Stephen Sharkady, Gene H. Kim, Gregory A. Taylor, Kenneth L. Byron, and Lucia Schuger. “Blood pressure homeostasis is maintained by a P311-TGF-β axis.” J Clin Invest 123, no. 10 (October 2013): 4502–12. https://doi.org/10.1172/JCI69884.Full Text Link to Item
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Springer, Helen M., Michael Schramm, Gregory A. Taylor, and Jonathan C. Howard. “Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.” J Immunol 191, no. 4 (August 15, 2013): 1765–74. https://doi.org/10.4049/jimmunol.1300641.Full Text Link to Item
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Traver, M. K., S. C. Henry, V. Cantillana, T. Oliver, J. P. Hunn, J. C. Howard, S. Beer, K. Pfeffer, J. Coers, and G. A. Taylor. “Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.” J Biol Chem 288, no. 16 (April 19, 2013): 11504. https://doi.org/10.1074/jbc.A111.251967.Full Text Link to Item
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Haldar, Arun K., Hector A. Saka, Anthony S. Piro, Joe Dan Dunn, Stanley C. Henry, Gregory A. Taylor, Eva M. Frickel, Raphael H. Valdivia, and Jörn Coers. “IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.” Plos Pathog 9, no. 6 (2013): e1003414. https://doi.org/10.1371/journal.ppat.1003414.Full Text Link to Item
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Morey, Miriam C., Carl F. Pieper, David E. Edelman, William S. Yancy, Jennifer B. Green, Helen Lum, Matthew J. Peterson, et al. “Enhanced fitness: a randomized controlled trial of the effects of home-based physical activity counseling on glycemic control in older adults with prediabetes mellitus.” J Am Geriatr Soc 60, no. 9 (September 2012): 1655–62. https://doi.org/10.1111/j.1532-5415.2012.04119.x.Full Text Link to Item
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Skariah, Sini, Robert B. Bednarczyk, Matthew K. McIntyre, Gregory A. Taylor, and Dana G. Mordue. “Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates.” J Immunol 188, no. 7 (April 1, 2012): 3404–15. https://doi.org/10.4049/jimmunol.1101425.Full Text Link to Item
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Klionsky, Daniel J., Fabio C. Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy 8, no. 4 (April 2012): 445–544. https://doi.org/10.4161/auto.19496.Full Text Link to Item
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Behnke, Michael S., Sarah J. Fentress, Mona Mashayekhi, Lucy X. Li, Gregory A. Taylor, and L David Sibley. “The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.” Plos Pathog 8, no. 11 (2012): e1002992. https://doi.org/10.1371/journal.ppat.1002992.Full Text Link to Item
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Liu, Zhen, Huifang M. Zhang, Ji Yuan, Xin Ye, Gregory A. Taylor, and Decheng Yang. “The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.” Cell Microbiol 14, no. 1 (January 2012): 133–46. https://doi.org/10.1111/j.1462-5822.2011.01708.x.Full Text Link to Item
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Hall, Katherine S., Carl F. Pieper, David E. Edelman, William S. Yancy, Jennifer B. Green, Helen Lum, Matthew J. Peterson, et al. “Lessons learned when innovations go awry: a baseline description of a behavioral trial-the Enhancing Fitness in Older Overweight Veterans with Impaired Fasting Glucose study.” Transl Behav Med 1, no. 4 (November 2011): 573–87. https://doi.org/10.1007/s13142-011-0075-6.Full Text Link to Item
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Lippmann, Juliane, Holger C. Müller, Jan Naujoks, Christoph Tabeling, Sunny Shin, Martin Witzenrath, Katharina Hellwig, et al. “Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.” Cell Microbiol 13, no. 11 (November 2011): 1668–82. https://doi.org/10.1111/j.1462-5822.2011.01646.x.Full Text Link to Item
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Traver, Maria K., Stanley C. Henry, Viviana Cantillana, Tim Oliver, Julia P. Hunn, Jonathan C. Howard, Sandra Beer, Klaus Pfeffer, Jörn Coers, and Gregory A. Taylor. “Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.” J Biol Chem 286, no. 35 (September 2, 2011): 30471–80. https://doi.org/10.1074/jbc.M111.251967.Full Text Link to Item
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King, Katherine Y., Megan T. Baldridge, David C. Weksberg, Stuart M. Chambers, Georgi L. Lukov, Shihua Wu, Nathan C. Boles, et al. “Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.” Blood 118, no. 6 (August 11, 2011): 1525–33. https://doi.org/10.1182/blood-2011-01-328682.Full Text Link to Item
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Coers, Jörn, Dave C. Gondek, Andrew J. Olive, Amy Rohlfing, Gregory A. Taylor, and Michael N. Starnbach. “Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.” Plos Pathog 7, no. 6 (June 2011): e1001346. https://doi.org/10.1371/journal.ppat.1001346.Full Text Link to Item
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Bargen, Kristine von, Jens Wohlmann, Gregory Alan Taylor, Olaf Utermöhlen, and Albert Haas. “Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.” Infect Immun 79, no. 5 (May 2011): 2098–2111. https://doi.org/10.1128/IAI.00983-10.Full Text Link to Item
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Lum, Helen, Richard Sloane, Kim M. Huffman, Virginia B. Kraus, Dana K. Thompson, William E. Kraus, James R. Bain, et al. “Plasma acylcarnitines are associated with physical performance in elderly men.” J Gerontol a Biol Sci Med Sci 66, no. 5 (May 2011): 548–53. https://doi.org/10.1093/gerona/glr006.Full Text Link to Item
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Fentress, Sarah J., Michael S. Behnke, Ildiko R. Dunay, Mona Mashayekhi, Leah M. Rommereim, Barbara A. Fox, David J. Bzik, et al. “Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.” Cell Host Microbe 8, no. 6 (December 16, 2010): 484–95. https://doi.org/10.1016/j.chom.2010.11.005.Full Text Link to Item
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Vignola, Mark J., David F. Kashatus, Gregory A. Taylor, Christopher M. Counter, and Raphael H. Valdivia. “cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.” J Biol Chem 285, no. 28 (July 9, 2010): 21625–35. https://doi.org/10.1074/jbc.M110.103010.Full Text Link to Item
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Xu, Hongwei, Zhi-Ying Wu, Fang Fang, Lan Guo, Doris Chen, John Xi Chen, David Stern, Gregory A. Taylor, Hong Jiang, and Shirley ShiDu Yan. “Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells.” Faseb J 24, no. 5 (May 2010): 1583–92. https://doi.org/10.1096/fj.09-137323.Full Text Link to Item
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Henry, Stanley C., Maria Traver, Xiaojou Daniell, Maanasa Indaram, Tim Oliver, and Gregory A. Taylor. “Regulation of macrophage motility by Irgm1.” J Leukoc Biol 87, no. 2 (February 2010): 333–43. https://doi.org/10.1189/jlb.0509299.Full Text Link to Item
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Zhao, Yang O., Stephanie Könen-Waisman, Gregory A. Taylor, Sascha Martens, and Jonathan C. Howard. “Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.” Plos One 5, no. 1 (January 13, 2010): e8648. https://doi.org/10.1371/journal.pone.0008648.Full Text Open Access Copy Link to Item
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Zhao, Y. O., S. Könen-Waisman, G. A. Taylor, S. Martens, and J. C. Howard. “Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.” Plos One 5, no. 1 (2010). https://doi.org/10.1371/journal.pone.0008648.Full Text
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Henry, Stanley C., Xiaoju G. Daniell, Ashley R. Burroughs, Maanasa Indaram, David N. Howell, Jörn Coers, Michael N. Starnbach, et al. “Balance of Irgm protein activities determines IFN-gamma-induced host defense.” J Leukoc Biol 85, no. 5 (May 2009): 877–85. https://doi.org/10.1189/jlb.1008599.Full Text Link to Item
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Taylor, Gregory A., Ramona M. Rodriguiz, Robert I. Greene, Xiaoju Daniell, Stanley C. Henry, Kristy R. Crooks, Robert Kotloski, Lino Tessarollo, Lindsey E. Phillips, and William C. Wetsel. “Behavioral characterization of P311 knockout mice.” Genes Brain Behav 7, no. 7 (October 2008): 786–95. https://doi.org/10.1111/j.1601-183X.2008.00420.x.Full Text Link to Item
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Sukhumavasi, Woraporn, Charlotte E. Egan, Amy L. Warren, Gregory A. Taylor, Barbara A. Fox, David J. Bzik, and Eric Y. Denkers. “TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite.” J Immunol 181, no. 5 (September 1, 2008): 3464–73. https://doi.org/10.4049/jimmunol.181.5.3464.Full Text Link to Item
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Liu, Zhen, Huifang M. Zhang, Ji Yuan, Travis Lim, Alhousseynou Sall, Gregory A. Taylor, and Decheng Yang. “Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.” Cell Microbiol 10, no. 9 (September 2008): 1787–1800. https://doi.org/10.1111/j.1462-5822.2008.01165.x.Full Text Link to Item
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Sun, Yan-Gang, Yong-Jing Gao, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A. Taylor, and Zhou-Feng Chen. “Involvement of P311 in the affective, but not in the sensory component of pain.” Mol Pain 4 (June 12, 2008): 23. https://doi.org/10.1186/1744-8069-4-23.Full Text Link to Item
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Coers, Jörn, Isaac Bernstein-Hanley, David Grotsky, Iana Parvanova, Jonathan C. Howard, Gregory A. Taylor, William F. Dietrich, and Michael N. Starnbach. “Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.” J Immunol 180, no. 9 (May 1, 2008): 6237–45. https://doi.org/10.4049/jimmunol.180.9.6237.Full Text Link to Item
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Feng, Carl G., David C. Weksberg, Gregory A. Taylor, Alan Sher, and Margaret A. Goodell. “The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.” Cell Stem Cell 2, no. 1 (January 10, 2008): 83–89. https://doi.org/10.1016/j.stem.2007.10.007.Full Text Link to Item
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Henry, Stanley C., Xiaojou Daniell, Maanasa Indaram, John F. Whitesides, Gregory D. Sempowski, David Howell, Tim Oliver, and Gregory A. Taylor. “Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).” J Immunol 179, no. 10 (November 15, 2007): 6963–72. https://doi.org/10.4049/jimmunol.179.10.6963.Full Text Link to Item
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Bafica, Andre, Carl G. Feng, Helton C. Santiago, Julio Aliberti, Allen Cheever, Karen E. Thomas, Gregory A. Taylor, Stefanie N. Vogel, and Alan Sher. “The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.” J Immunol 179, no. 8 (October 15, 2007): 5514–22. https://doi.org/10.4049/jimmunol.179.8.5514.Full Text Link to Item
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Taylor, Gregory A. “IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.” Cell Microbiol 9, no. 5 (May 2007): 1099–1107. https://doi.org/10.1111/j.1462-5822.2007.00916.x.Full Text Link to Item
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Yates, Robin M., Albin Hermetter, Gregory A. Taylor, and David G. Russell. “Macrophage activation downregulates the degradative capacity of the phagosome.” Traffic 8, no. 3 (March 2007): 241–50. https://doi.org/10.1111/j.1600-0854.2006.00528.x.Full Text Link to Item
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Taylor, Gregory A., Carl G. Feng, and Alan Sher. “Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).” Microbes Infect 9, no. 14–15 (2007): 1644–51. https://doi.org/10.1016/j.micinf.2007.09.004.Full Text Link to Item
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Bernstein-Hanley, Isaac, Jörn Coers, Zarine R. Balsara, Gregory A. Taylor, Michael N. Starnbach, and William F. Dietrich. “The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.” Proc Natl Acad Sci U S A 103, no. 38 (September 19, 2006): 14092–97. https://doi.org/10.1073/pnas.0603338103.Full Text Link to Item
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Singh, Sudha B., Alexander S. Davis, Gregory A. Taylor, and Vojo Deretic. “Human IRGM induces autophagy to eliminate intracellular mycobacteria.” Science 313, no. 5792 (September 8, 2006): 1438–41. https://doi.org/10.1126/science.1129577.Full Text Link to Item
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Ling, Y. M., M. H. Shaw, C. Ayala, I. Coppens, G. A. Taylor, D. J. P. Ferguson, and G. S. Yap. “Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.” Journal of Experimental Medicine 203, no. 9 (September 4, 2006): 2063–71. https://doi.org/10.1084/jem.20061318.Full Text
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Ling, Yun M., Michael H. Shaw, Carol Ayala, Isabelle Coppens, Gregory A. Taylor, David J. P. Ferguson, and George S. Yap. “Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.” J Exp Med 203, no. 9 (September 4, 2006): 2063–71. https://doi.org/10.1084/jem.20061318.Full Text Link to Item
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Santiago, H. C., C. G. Feng, A. Bafica, E. Roffe, R. M. Arantes, A. Cheever, G. Taylor, et al. “Erratum: Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth (Journal of Immunology (2005) 175 (8165-8172)).” Journal of Immunology 176, no. 6 (March 15, 2006): 3840.
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Santiago, Helton C., Carl G. Feng, Andre Bafica, Ester Roffe, Rosa M. Arantes, Allen Cheever, Gregory Taylor, et al. “Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.” J Immunol 175, no. 12 (December 15, 2005): 8165–72. https://doi.org/10.4049/jimmunol.175.12.8165.Full Text Link to Item
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Butcher, Barbara A., Robert I. Greene, Stanley C. Henry, Kimberly L. Annecharico, J Brice Weinberg, Eric Y. Denkers, Alan Sher, and Gregory A. Taylor. “p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.” Infect Immun 73, no. 6 (June 2005): 3278–86. https://doi.org/10.1128/IAI.73.6.3278-3286.2005.Full Text Link to Item
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Gutierrez, Maximiliano G., Sharon S. Master, Sudha B. Singh, Gregory A. Taylor, Maria I. Colombo, and Vojo Deretic. “Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.” Cell 119, no. 6 (December 17, 2004): 753–66. https://doi.org/10.1016/j.cell.2004.11.038.Full Text Link to Item
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Advani, Anjali S., Holly K. Dressman, Marisol Quiroz, Gregory A. Taylor, and Ann Marie Pendergast. “Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis.” Leuk Res 28, no. 3 (March 2004): 285–94. https://doi.org/10.1016/s0145-2126(03)00264-9.Full Text Link to Item
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Gavrilescu, L Cristina, Barbara A. Butcher, Laura Del Rio, Gregory A. Taylor, and Eric Y. Denkers. “STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection.” Infect Immun 72, no. 3 (March 2004): 1257–64. https://doi.org/10.1128/IAI.72.3.1257-1264.2004.Full Text Link to Item
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Taylor, Gregory A., Carl G. Feng, and Alan Sher. “p47 GTPases: regulators of immunity to intracellular pathogens.” Nat Rev Immunol 4, no. 2 (February 2004): 100–109. https://doi.org/10.1038/nri1270.Full Text Link to Item
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Feng, Carl G., Carmen M. Collazo-Custodio, Michael Eckhaus, Sara Hieny, Yasmine Belkaid, Karen Elkins, Dragana Jankovic, Gregory A. Taylor, and Alan Sher. “Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.” J Immunol 172, no. 2 (January 15, 2004): 1163–68. https://doi.org/10.4049/jimmunol.172.2.1163.Full Text Link to Item
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Souza, A. P. de, B. Tang, H. B. Tanowitz, S. M. Factor, V. Shtutin, J. Shirani, G. A. Taylor, L. M. Weiss, and L. A. Jelicks. “Absence of interferon-gamma-inducible gene IGTP does not significantly alter the development of chagasic cardiomyopathy in mice infected with Trypanosoma cruzi (Brazil strain).” J Parasitol 89, no. 6 (December 2003): 1237–39. https://doi.org/10.1645/GE-3185RN.Full Text Link to Item
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MacMicking, John D., Gregory A. Taylor, and John D. McKinney. “Immune control of tuberculosis by IFN-gamma-inducible LRG-47.” Science 302, no. 5645 (October 24, 2003): 654–59. https://doi.org/10.1126/science.1088063.Full Text Link to Item
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Collazo, Carmen M., George S. Yap, Sara Hieny, Patricia Caspar, Carl G. Feng, Gregory A. Taylor, and Alan Sher. “The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments.” Infect Immun 70, no. 12 (December 2002): 6933–39. https://doi.org/10.1128/IAI.70.12.6933-6939.2002.Full Text Link to Item
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Pan, Desi, Xiaoning Zhe, Sandhya Jakkaraju, Gregory A. Taylor, and Lucia Schuger. “P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype.” J Clin Invest 110, no. 9 (November 2002): 1349–58. https://doi.org/10.1172/JCI15614.Full Text Link to Item
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Desi, P., X. N. Zhe, G. A. Taylor, and L. Schuger. “P311, a small protein with several PEST motifs, plays a role in myofibroblast differentiation.” Molecular Biology of the Cell 12 (November 1, 2001): 368A-369A.Link to Item
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Halonen, S. K., G. A. Taylor, and L. M. Weiss. “Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.” Infect Immun 69, no. 9 (September 2001): 5573–76. https://doi.org/10.1128/IAI.69.9.5573-5576.2001.Full Text Link to Item
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Collazo, C. M., G. S. Yap, G. D. Sempowski, K. C. Lusby, L. Tessarollo, G. F. Vande Woude, A. Sher, and G. A. Taylor. “Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.” J Exp Med 194, no. 2 (July 16, 2001): 181–88. https://doi.org/10.1084/jem.194.2.181.Full Text Link to Item
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Collazo, C. M., G. S. Yap, G. A. Taylor, and A. Sher. “The IFN-gamma-inducible GTPase (IGTP) is required for in vivo control of Toxoplasma gondii infection in both hematopoeitic and non-hematopoeitic host cells.” Faseb Journal 14, no. 6 (April 20, 2000): A955–A955.Link to Item
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Taylor, G. A., E. Hudson, J. H. Resau, and G. F. Vande Woude. “Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system.” J Biol Chem 275, no. 6 (February 11, 2000): 4215–19. https://doi.org/10.1074/jbc.275.6.4215.Full Text Link to Item
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Taylor, G. A., C. M. Collazo, G. S. Yap, K. Nguyen, T. A. Gregorio, L. S. Taylor, B. Eagleson, et al. “Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.” Proc Natl Acad Sci U S A 97, no. 2 (January 18, 2000): 751–55. https://doi.org/10.1073/pnas.97.2.751.Full Text Link to Item
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Ravin, C. E., B. P. Drayer, B. J. Manaster, G. A. Taylor, W. M. Thompson, and W. R. Webb. “Image interpretation session: Sunday, November 26, 2000.” Radiographics 20, no. 5 (2000): 1507–19. https://doi.org/10.1148/radiographics.20.5.g00se241507.Full Text Link to Item
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Koochekpour, S., M. Jeffers, P. H. Wang, C. Gong, G. A. Taylor, L. M. Roessler, R. Stearman, et al. “The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.” Mol Cell Biol 19, no. 9 (September 1999): 5902–12. https://doi.org/10.1128/MCB.19.9.5902.Full Text Link to Item
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Webb, C. P., G. A. Taylor, M. Jeffers, M. Fiscella, M. Oskarsson, J. H. Resau, and G. F. Vande Woude. “Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.” Oncogene 17, no. 16 (October 22, 1998): 2019–25. https://doi.org/10.1038/sj.onc.1202135.Full Text Link to Item
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Taylor, G. A., M. Jeffers, C. P. Webb, H. M. Koo, M. Anver, K. Sekiguchi, and G. F. Vande Woude. “Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.” Oncogene 17, no. 9 (September 3, 1998): 1179–83. https://doi.org/10.1038/sj.onc.1202004.Full Text Link to Item
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Koochekpour, S., M. Jeffers, S. Rulong, G. Taylor, E. Klineberg, E. A. Hudson, J. H. Resau, and G. F. Vande Woude. “Met and hepatocyte growth factor/scatter factor expression in human gliomas.” Cancer Res 57, no. 23 (December 1, 1997): 5391–98.Link to Item
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Taylor, G. A., R. Stauber, S. Rulong, E. Hudson, V. Pei, G. N. Pavlakis, J. H. Resau, and G. F. Vande Woude. “The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.” J Biol Chem 272, no. 16 (April 18, 1997): 10639–45. https://doi.org/10.1074/jbc.272.16.10639.Full Text Link to Item
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Jeffers, M., G. A. Taylor, K. M. Weidner, S. Omura, and G. F. Vande Woude. “Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.” Mol Cell Biol 17, no. 2 (February 1997): 799–808. https://doi.org/10.1128/MCB.17.2.799.Full Text Link to Item
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Thompson, M. J., W. S. Lai, G. A. Taylor, and P. J. Blackshear. “Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.” Gene 174, no. 2 (October 3, 1996): 225–33. https://doi.org/10.1016/0378-1119(96)00084-4.Full Text Link to Item
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Taylor, G. A., M. Jeffers, D. A. Largaespada, N. A. Jenkins, N. G. Copeland, and G. F. Vande Woude. “Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma.” J Biol Chem 271, no. 34 (August 23, 1996): 20399–405. https://doi.org/10.1074/jbc.271.34.20399.Full Text Link to Item
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Taylor, G. A., E. Carballo, D. M. Lee, W. S. Lai, M. J. Thompson, D. D. Patel, D. I. Schenkman, et al. “A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.” Immunity 4, no. 5 (May 1996): 445–54. https://doi.org/10.1016/s1074-7613(00)80411-2.Full Text Link to Item
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Taylor, G. A., M. J. Thompson, W. S. Lai, and P. J. Blackshear. “Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor.” Mol Endocrinol 10, no. 2 (February 1996): 140–46. https://doi.org/10.1210/mend.10.2.8825554.Full Text Link to Item
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Lai, W. S., M. J. Thompson, G. A. Taylor, Y. Liu, and P. J. Blackshear. “Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin.” J Biol Chem 270, no. 42 (October 20, 1995): 25266–72. https://doi.org/10.1074/jbc.270.42.25266.Full Text Link to Item
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Taylor, G. A., M. J. Thompson, W. S. Lai, and P. J. Blackshear. “Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro.” J Biol Chem 270, no. 22 (June 2, 1995): 13341–47. https://doi.org/10.1074/jbc.270.22.13341.Full Text Link to Item
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Taylor, G. A., and P. J. Blackshear. “Zinc inhibits turnover of labile mRNAs in intact cells.” J Cell Physiol 162, no. 3 (March 1995): 378–87. https://doi.org/10.1002/jcp.1041620310.Full Text Link to Item
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Taylor, G. A., W. S. Lai, R. J. Oakey, M. F. Seldin, T. B. Shows, R. L. Eddy, and P. J. Blackshear. “The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes.” Nucleic Acids Res 19, no. 12 (June 25, 1991): 3454. https://doi.org/10.1093/nar/19.12.3454.Full Text Link to Item
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Other Articles
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Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.Full Text Link to Item
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Conference Papers
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Huang, Hsin-I, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, et al. “Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.” In Front Immunol, 12:661290, 2021. https://doi.org/10.3389/fimmu.2021.661290.Full Text Link to Item
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King, K. Y., M. T. Baldridge, D. C. Weksberg, N. T. Eissa, G. A. Taylor, and M. A. Goodell. “IRGM1 IS A NEGATIVE REGULATOR OF INTERFERON SIGNALING AND AUTOPHAGY IN THE HEMATOPOIETIC STEM CELL.” In Experimental Hematology, 38:S21–S21. ELSEVIER SCIENCE INC, 2010.Link to Item
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Advani, A. S., H. K. Dressman, M. Quiroz, G. A. Taylor, and A. M. Pendergast. “Elevated expression of numerous interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis.” In Blood, 100:584A-584A. AMER SOC HEMATOLOGY, 2002.Link to Item
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