Gregory Allan Wray

Journal article Marine genomics · October 2021 Featured Publication The molecular mechanisms underlying development of the pentameral body of adult echinoderms are poorly understood but are important to solve with respect to evolution of a unique body plan that contrasts with the bilateral body plan of other deuterostomes. ... Full text Cite

An early cell shape transition drives evolutionary expansion of the human forebrain.

Journal article Cell · April 2021 Featured Publication The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla, and chimpanzee cells to study dev ... Full text Cite

TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death.

Journal article American journal of medical genetics. Part A · March 2021 Featured Publication Long QT syndrome (LQTS) is a genetic disease resulting in a prolonged QT interval on a resting electrocardiogram, predisposing affected individuals to polymorphic ventricular tachycardia and sudden death. Although a number of genes have been implicated in ... Full text Open Access Cite

The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia.

Journal article BMC biology · January 2021 Featured Publication BackgroundInhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are essential for development, oncogenesis, and immune and stress responses. However, available knowledge regarding IAP is largely biased toward humans ... Full text Cite