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Al-Hafeez Z Dhalla

Assistant Research Professor in the Department of Biomedical Engineering
Biomedical Engineering
PO Box 90281, Durham, NC 27708-0281
101 Science Drive, FCIEMAS 2574A, Durham, NC 27708-0281

Overview


My research focuses on the application of optical technologies for non-invasive, high-resolution imaging of biological tissues.  In particular, our laboratory develops optical coherence tomography (OCT), scanning laser ophthalmoscopy (SLO), light detection and ranging (LiDAR) and other optical imaging technologies for applications in the diagnosis and treatment of disease, particularly diseases of the eye. My work focuses not only on the engineering and technical development of novel imaging technologies, but also the preparation of these technologies for commercialization through clinical validation and regulatory approval.

Current Duke Appointments & Affiliations


Assistant Research Professor in the Department of Biomedical Engineering · 2019 - Present Biomedical Engineering, Pratt School of Engineering
Faculty Network Member of the Duke Institute for Brain Sciences · 2020 - Present Duke Institute for Brain Sciences, University Institutes and Centers

Recent Scholarly Works


Focus optimization for long-range OCT and short-range LiDAR

Journal article Optics Continuum · April 15, 2026 In focused Gaussian beam imaging systems, the low-numerical aperture (NA) of the beam inherently degrades signal and resolution. We demonstrate and experimentally validate a theory for optimally focusing a Gaussian beam source with a low-NA lens to maximiz ... Full text Cite

Optical Coherence Tomography with Fluorescein Optical Clearing for Transscleral Image Guidance

Journal article International Journal of Translational Medicine · March 1, 2026 Background: Scattering of the sclera limits optical coherence tomography (OCT) imaging of deeper targets including lesions, malignancies, and other surgical targets. While existing applications of fluorescein dye are currently focused on fluorescence prope ... Full text Cite

New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.

Journal article Transl Vis Sci Technol · January 2, 2025 The introduction of optical coherence tomography (OCT) in the 1990s revolutionized diagnostic ophthalmic imaging. Initially, OCT's role was primarily in the adult ambulatory ophthalmic clinics. Subsequent advances in handheld form factors, integration into ... Full text Link to item Cite
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Recent Grants


Auto-aligning hand-held OCT and OCTA for pediatric applications

ResearchPrincipal Investigator · Awarded by National Eye Institute · 2024 - 2027

Widefield Confocal Scanning Laser Ophthalmoscope Optimized for Pediatric and Neonatal Imaging

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

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Education


Duke University · 2012 Ph.D.