Al-Hafeez Z Dhalla | Scholars@Duke

Al-Hafeez Z Dhalla
Assist Research Professor in the Department of Biomedical Engineering

My research centers on the application of optical technologies for non-invasive, high-resolution imaging of biological tissues. In particular, I focus on applications of optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) in the diagnosis and treatment of diseases of the eye. My work focuses not only on the engineering and technical development of novel imaging technologies, but also the preparation of these technologies for commercialization through clinical validation and regulatory approval.

Current Appointments & Affiliations

Assist Research Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2019
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2020

Contact Information

101 Science Drive, Fciemas 2574A, Durham, NC 27708-0281
PO Box 90281, Durham, NC 27708-0281

Background
Education, Training, & Certifications
- Ph.D., Duke University 2012
Research
Selected Grants
- Automated OCT Technology Translation to Diagnose Traumatic Eye Injury 2020 - 2023
- Handheld Confocal Scanning Laser Ophthalmoscope for Remote Screening of Diabetic Retinopathy awarded by National Institutes of Health 2019 - 2021
External Relationships
- Coherence Consulting LLC
- Leica Microsystems
- Theia Imaging LLC
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Nankivil, Derek, Al-Hafeez Dhalla, Niklas Gahm, Kevin Shia, Sina Farsiu, and Joseph A. Izatt. “Coherence revival multiplexed, buffered swept source optical coherence tomography: 400 kHz imaging with a 100 kHz source.” Optics Letters 39, no. 13 (July 2014): 3740–43. https://doi.org/10.1364/ol.39.003740.
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  - Liu, Jonathan J., Andre J. Witkin, Mehreen Adhi, Ireneusz Grulkowski, Martin F. Kraus, Al-Hafeez Dhalla, Chen D. Lu, Joachim Hornegger, Jay S. Duker, and James G. Fujimoto. “Enhanced vitreous imaging in healthy eyes using swept source optical coherence tomography.” Plos One 9, no. 7 (January 2014): e102950. https://doi.org/10.1371/journal.pone.0102950.
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  - LaRocca, Francesco, Al-Hafeez Dhalla, Michael P. Kelly, Sina Farsiu, and Joseph A. Izatt. “Optimization of confocal scanning laser ophthalmoscope design.” Journal of Biomedical Optics 18, no. 7 (July 2013): 076015. https://doi.org/10.1117/1.jbo.18.7.076015.
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  - Tokayer, J., Y. Jia, A. H. Dhalla, and D. Huang. “Blood flow velocity quantification using splitspectrum amplitude-decorrelation angiography with optical coherence tomography.” Biomedical Optics Express 4, no. 10 (January 1, 2013): 1909–24. https://doi.org/10.1364/BOE.4.001909.
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  - Chowdhury, S., A. H. Dhalla, and J. Izatt. “Coherent super-resolution structured illumination microscopy of non-fluorescent samples.” Biomedical Optics, Biomed 2012, December 1, 2012.
  - Dhalla, A. H., D. Nankivil, T. Bustamante, A. Kuo, and J. A. Izatt. “Simultaneous swept source optical coherence tomography of the anterior segment and retina.” Biomedical Optics, Biomed 2012, December 1, 2012.
  - Dhalla, Al-Hafeez, Kevin Shia, and Joseph A. Izatt. “Efficient sweep buffering in swept source optical coherence tomography using a fast optical switch.” Biomedical Optics Express 3, no. 12 (December 2012): 3054–66. https://doi.org/10.1364/boe.3.003054.
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  - Chowdhury, Shwetadwip, Al-Hafeez Dhalla, and Joseph Izatt. “Structured oblique illumination microscopy for enhanced resolution imaging of non-fluorescent, coherently scattering samples.” Biomedical Optics Express 3, no. 8 (August 2012): 1841–54. https://doi.org/10.1364/boe.3.001841.
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  - Dhalla, Al-Hafeez, Derek Nankivil, Theresa Bustamante, Anthony Kuo, and Joseph A. Izatt. “Simultaneous swept source optical coherence tomography of the anterior segment and retina using coherence revival.” Opt Lett 37, no. 11 (June 1, 2012): 1883–85. https://doi.org/10.1364/OL.37.001883.
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  - Dhalla, Al-Hafeez, Derek Nankivil, and Joseph A. Izatt. “Complex conjugate resolved heterodyne swept source optical coherence tomography using coherence revival.” Biomedical Optics Express 3, no. 3 (March 2012): 633–49. https://doi.org/10.1364/boe.3.000633.
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  - Hendargo, Hansford C., Ryan P. McNabb, Al-Hafeez Dhalla, Neal Shepherd, and Joseph A. Izatt. “Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography.” Biomedical Optics Express 2, no. 8 (August 2011): 2175–88. https://doi.org/10.1364/boe.2.002175.
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  - Dhalla, Al-Hafeez, and Joseph A. Izatt. “Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line.” Biomedical Optics Express 2, no. 5 (April 15, 2011): 1218–32. https://doi.org/10.1364/boe.2.001218.
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  - Hendargo, H. C., R. P. McNabb, A. H. Dhalla, N. Shepherd, and J. A. Izatt. “Doppler velocity detection limitations in spectrometer and swept-source Fourier-domain optical coherence tomography.” Progress in Biomedical Optics and Imaging Proceedings of Spie 7889 (April 12, 2011). https://doi.org/10.1117/12.876013.
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  - Dhalla, Al-Hafeez, Justin V. Migacz, and Joseph A. Izatt. “Crosstalk rejection in parallel optical coherence tomography using spatially incoherent illumination with partially coherent sources.” Optics Letters 35, no. 13 (July 2010): 2305–7. https://doi.org/10.1364/ol.35.002305.
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  - Dhalla, A. H., J. Migacz, and J. A. Izatt. “Crosstalk rejection in full-field optical coherence tomography using spatially incoherent illumination with a partially coherent source.” Progress in Biomedical Optics and Imaging Proceedings of Spie 7554 (May 3, 2010). https://doi.org/10.1117/12.843391.
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  - Yu, Bing, Elizabeth S. Burnside, Gale A. Sisney, Josephine M. Harter, Changfang Zhu, Al-Hafeez Dhalla, and Nirmala Ramanujam. “Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing imageguided core-needle biopsy.” Opt Express 15, no. 12 (June 11, 2007): 7335–50. https://doi.org/10.1364/oe.15.007335.
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- Book Sections
  - Izatt, J. A., M. A. Choma, and A. H. Dhalla. “Theory of optical coherence tomography.” In Optical Coherence Tomography: Technology and Applications, Second Edition, 65–94, 2015. https://doi.org/10.1007/978-3-319-06419-2_2.
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Teaching & Mentoring
Teaching Activities
- Prof. Dhalla routinely guest lectures on quality management, design control and government regulation of medical devices in BME senior design capstone courses.

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Education, Training, & Certifications

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Teaching Activities