Scholars@Duke
Michael Martin Haglund

Michael Martin Haglund

Duke Surgery Distinguished Professor of Neurosurgery in the School of Medicine
Neurosurgery
michael.haglund@duke.edu
Box 3807 Med Ctr, Durham, NC 27710
4508 Hosp South - Blue Zone, Durham, NC 27710

Featured Works

Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: Clinical article.

Journal article J Neurosurg Spine · October 2014 Featured Publication OBJECT: The Accreditation Council for Graduate Medical Education (ACGME) implemented resident duty-hour restrictions on July 1, 2003, in concern for patient and resident safety. Whereas studies have shown that duty-hour restrictions have increased resident ... Full text Link to item Cite

Correlation of intrinsic optical signal, cerebral blood flow, and evoked potentials during activation of rat somatosensory cortex.

Journal article J Neurosurg · October 2008 Featured Publication OBJECT: This study was undertaken to test the hypothesis that cerebral blood flow (CBF) and the intrinsic optical signal could be dissociated by altering adenosine receptor activity and to uncover the origin of the optic signal using a cranial window in th ... Full text Link to item Cite

Imaging of intrinsic optical signals in primate cortex during epileptiform activity.

Journal article Epilepsia · 2007 Featured Publication Localized increases in neuronal activity are known to alter the distribution and oxygen content of blood within the surrounding brain tissue. In the neocortex, these activity-evoked hemodynamic changes are predominantly mediated through the dilation of the ... Full text Link to item Cite

Furosemide and mannitol suppression of epileptic activity in the human brain.

Journal article J Neurophysiol · August 2005 Featured Publication Most research on basic mechanisms of epilepsy and the design of new antiepileptic drugs has focused on synaptic transmission or action potential generation. However, a number of laboratory studies have suggested that nonsynaptic mechanisms, such as modulat ... Full text Link to item Cite

Optical imaging of epileptiform activity in human neocortex.

Journal article Epilepsia · 2004 Featured Publication The surgical outcomes of patients suffering from neocortical epilepsy are not as successful as the surgical outcomes from resections of epilepsy patients with mesial temporal sclerosis. The main difficulty in the treatment of neocortical epilepsy is that c ... Full text Link to item Cite

Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.

Journal article Stroke · February 2003 Featured Publication BACKGROUND AND PURPOSE: During vasospasm after subarachnoid hemorrhage (SAH), cerebral blood vessels show structural changes consistent with the actions of vascular mitogens. We measured platelet-derived vascular growth factors (PDGFs) in the cerebrospinal ... Link to item Cite

Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs.

Journal article J Am Vet Med Assoc · October 1, 2002 Featured Publication OBJECTIVE: To evaluate safety and efficacy of vagal nerve stimulation in dogs with refractory epilepsy. DESIGN: Placebo-controlled, double-masked, crossover study. ANIMALS: 10 dogs with poorly controlled seizures. PROCEDURE: A programmable pacemaker-like d ... Full text Link to item Cite

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.

Journal article J Clin Oncol · May 1, 2002 Featured Publication PURPOSE: We conducted a phase II trial of carmustine (BCNU) plus the O(6)-alkylguanine-DNA alkyltransferase inhibitor O(6)-benzylguanine (O(6)-BG) to define the activity and toxicity of this regimen in the treatment of adults with progressive or recurrent ... Full text Link to item Cite

Electrophysiological correlates to the intrinsic optical signal in the rat neocortical slice.

Journal article Neurosci Lett · January 14, 2002 Featured Publication The study sought to further our understanding of the correlation between electrophysiological activity and the intrinsic optical signal (IOS) in neocortical slice by combining imaging of IOS with whole-cell and extracellular electrical recording. Columnar- ... Full text Link to item Cite

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal article J Clin Oncol · October 15, 2000 Featured Publication PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT), which removes chloroethylation or methylation damage from the O(6) position of guanine. O(6)-benzylguanine ... Full text Link to item Cite

Asymmetry of neuronal activity during extracellular microelectrode recording from left and right human temporal lobe neocortex during rhyming and line-matching.

Journal article J Cogn Neurosci · September 2000 Featured Publication Recordings of neuronal activity in humans have identified few correlates of the known hemispheric asymmetries of functional lateralization. Here, we examine single-unit activity recorded from both hemispheres during two delayed match-to-sample tasks that s ... Full text Link to item Cite

Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery.

Journal article J Neurosurg · July 2000 Featured Publication OBJECT: Among the variety of surgical procedures that are performed for the treatment of medically refractory mesial temporal lobe epilepsy (TLE), no consensus exists as to how much of the hippocampus should be removed. Whether all patients require a maxim ... Full text Link to item Cite

The role of spatiotemporal edges in visibility and visual masking.

Journal article Proc Natl Acad Sci U S A · June 20, 2000 Featured Publication What parts of a visual stimulus produce the greatest neural signal? Previous studies have explored this question and found that the onset of a stimulus's edge is what excites early visual neurons most strongly. The role of inhibition at the edges of stimul ... Full text Link to item Cite

Optical images of visible and invisible percepts in the primary visual cortex of primates.

Journal article Proc Natl Acad Sci U S A · December 21, 1999 Featured Publication We optically imaged a visual masking illusion in primary visual cortex (area V-1) of rhesus monkeys to ask whether activity in the early visual system more closely reflects the physical stimulus or the generated percept. Visual illusions can be a powerful ... Full text Link to item Cite