Hai Yan | Scholars@Duke

Hai Yan
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine

Our research activities center on the molecular genetics and biology of cancer with a focus on the identification, characterization, and therapeutic targeting of driver mutations involved in the genesis and progression of brain cancers. Gliomas are the most common type of primary brain tumor. Through genomic studies, we have identified mutations in IDH1 and IDH2 in 70% of progressive malignant gliomas. These are somatic missense mutations that alter a conserved arginine residue and gain a neomorphic activity. A new metabolite produced by the glioma cells impacts on chromatin modulation and genome methylation. Malignant cells must maintain their telomeres. We identified several different tumor types exhibiting a high frequency of TERT promoter mutations, including several glioma subtypes. Conversely, we found a low frequency of TERT promoter mutations in many common epithelial tumors. In gliomas, we found that TERT promoter mutations were mutually exclusive with ATRX alterations, which are associated with activation of the ALT pathway for telomere maintenance. These findings show that TERT promoter mutations are frequent driver events in many human cancers, particularly those that arise from tissues with low rates of self-renewal. Our long-term goal is to develop a novel molecular-based glioma classification system and a targeted therapy on the basis of IDH1 and TERT mutations. To provide novel avenues for development of anticancer therapeutics, studies involving cell line and animal models, enzymatic study, metabolome and epigenome, are being investigated to determine the consequences of IDH1 and TERT mutations on cancer cells.

Current Appointments & Affiliations

Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology, Clinical Science Departments 2014
Professor of Pathology, Pathology, Clinical Science Departments 2012
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003

Contact Information

199B MSRB, Research Drive, Durham, NC 27710
Duke Box 3156, Department Of Pathology, Durham, NC 27710
hai.yan@duke.edu (919) 668-7850

Background
Education, Training, & Certifications
- Faculty, Research Associate, Molecular Genetics, Thomas Jefferson University 2002 - 2003
- Research Associate, Howard Hughes Institute, Johns Hopkins University 1997 - 2002
- Ph.D., Columbia University 1997
- M.D., Beijing Medical University (China) 1991
Duke Appointment History
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2011 - 2012
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2009 - 2011
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2003 - 2009
- Instructor, Temporary of Pathology, Pathology, Clinical Science Departments 2003
Recognition
In the News
- JUN 2, 2014
  
  Newly Identified Brain Cancer Mutation Will Aid Drug Development
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Pan, C, Diplas, BH, Chen, X, Wu, Y, Xiao, X, Jiang, L, Geng, Y, Xu, C, Sun, Y, Zhang, P, Wu, W, Wang, Y, Wu, Z, Zhang, J, Jiao, Y, Yan, H, and Zhang, L. "Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA." Acta Neuropathologica 137, no. 2 (February 2019): 297-306. Full Text
  - Lee, DD, Leão, R, Komosa, M, Gallo, M, Zhang, CH, Lipman, T, Remke, M, Heidari, A, Nunes, NM, Apolónio, JD, Price, AJ, De Mello, RA, Dias, JS, Huntsman, D, Hermanns, T, Wild, PJ, Vanner, R, Zadeh, G, Karamchandani, J, Das, S, Taylor, MD, Hawkins, CE, Wasserman, JD, Figueiredo, A, Hamilton, RJ, Minden, MD, Wani, K, Diplas, B, Yan, H, Aldape, K, Akbari, MR, Danesh, A, Pugh, TJ, Dirks, PB, Castelo-Branco, P, and Tabori, U. "DNA hypermethylation within TERT promoter upregulates TERT expression in cancer." The Journal of Clinical Investigation 129, no. 1 (January 2019): 223-229. Full Text
  - Pan, C-C, Liu, J, Tang, J, Chen, X, Chen, F, Wu, Y-L, Geng, Y-B, Xu, C, Zhang, X, Wu, Z, Gao, P-Y, Zhang, J-T, Yan, H, Liao, H, and Zhang, L-W. "A machine learning-based prediction model of H3K27M mutations in brainstem gliomas using conventional MRI and clinical features." Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology 130 (January 2019): 172-179. Full Text
  - Baig, SM, Fatima, A, Tariq, M, Khan, TN, Ali, Z, Faheem, M, Mahmood, H, Killela, P, Waitkus, M, He, Y, Zhao, F, Wang, S, Jiao, Y, and Yan, H. "Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome." Familial Cancer (November 26, 2018). Full Text
  - Lei, K, Sun, R, Chen, LH, Diplas, BH, Moure, CJ, Wang, W, Hansen, LJ, Tao, Y, Chen, X, Chen, C-PJ, Greer, PK, Zhao, F, Yan, H, Bigner, DD, Huang, J, and He, Y. "Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells." Scientific Reports 8, no. 1 (August 21, 2018): 12507-null. Full Text
  - Chen, J, Jian, X, Deng, S, Ma, Z, Shou, X, Shen, Y, Zhang, Q, Song, Z, Li, Z, Peng, H, Peng, C, Chen, M, Luo, C, Zhao, D, Ye, Z, Shen, M, Zhang, Y, Zhou, J, Fahira, A, Wang, Y, Li, S, Zhang, Z, Ye, H, Li, Y, Shen, J, Chen, H, Tang, F, Yao, Z, Shi, Z, Chen, C, Xie, L, Wang, Y, Fu, C, Mao, Y, Zhou, L, Gao, D, Yan, H, Zhao, Y, Huang, C, and Shi, Y. "Identification of recurrent USP48 and BRAF mutations in Cushing's disease." Nature Communications 9, no. 1 (August 9, 2018): 3171-null. Full Text
  - Waitkus, MS, Diplas, BH, and Yan, H. "Biological Role and Therapeutic Potential of IDH Mutations in Cancer." Cancer Cell 34, no. 2 (August 2018): 186-195. (Review) Full Text
  - Chitneni, SK, Yan, H, and Zalutsky, MR. "Synthesis and Evaluation of a 18F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET." Acs Medicinal Chemistry Letters 9, no. 7 (July 2018): 606-611. Full Text
  - Pirozzi, CJ, and Yan, H. "Improved grading of IDH-mutated astrocytic gliomas." Nature Reviews. Neurology 14, no. 7 (July 2018): 383-384. Full Text
  - Shirahata, M, Ono, T, Stichel, D, Schrimpf, D, Reuss, DE, Sahm, F, Koelsche, C, Wefers, A, Reinhardt, A, Huang, K, Sievers, P, Shimizu, H, Nanjo, H, Kobayashi, Y, Miyake, Y, Suzuki, T, Adachi, J-I, Mishima, K, Sasaki, A, Nishikawa, R, Bewerunge-Hudler, M, Ryzhova, M, Absalyamova, O, Golanov, A, Sinn, P, Platten, M, Jungk, C, Winkler, F, Wick, A, Hänggi, D, Unterberg, A, Pfister, SM, Jones, DTW, van den Bent, M, Hegi, M, French, P, Baumert, BG, Stupp, R, Gorlia, T, Weller, M, Capper, D, Korshunov, A, Herold-Mende, C, Wick, W, Louis, DN, and von Deimling, A. "Novel, improved grading system(s) for IDH-mutant astrocytic gliomas." Acta Neuropathologica 136, no. 1 (July 2018): 153-166. Full Text
  - Jia, S, Zhang, M, Sun, Y, Yan, H, Zhao, F, Li, Z, and Ji, J. "A Chinese family affected by lynch syndrome caused by MLH1 mutation." Bmc Medical Genetics 19, no. 1 (June 22, 2018): 106-null. Full Text
  - Diplas, BH, He, X, Brosnan-Cashman, JA, Liu, H, Chen, LH, Wang, Z, Moure, CJ, Killela, PJ, Loriaux, DB, Lipp, ES, Greer, PK, Yang, R, Rizzo, AJ, Rodriguez, FJ, Friedman, AH, Friedman, HS, Wang, S, He, Y, McLendon, RE, Bigner, DD, Jiao, Y, Waitkus, MS, Meeker, AK, and Yan, H. "The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma." Nature Communications 9, no. 1 (May 25, 2018): 2087-null. Full Text
  - Chitneni, SK, Reitman, ZJ, Spicehandler, R, Gooden, DM, Yan, H, and Zalutsky, MR. "Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors." Bioorganic & Medicinal Chemistry Letters 28, no. 4 (February 2018): 694-699. Full Text
  - Tiburcio, PDB, Xiao, B, Berg, S, Asper, S, Lyne, S, Zhang, Y, Zhu, X, Yan, H, and Huang, LE. "Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis." Acta neuropathologica 135, no. 2 (February 2018): 285-298. Full Text
  - Huang, H, Shen, H, Wang, Y, Wang, X, Chen, Q, Yan, H, Liu, Z, and Shi, X. "LOH12CR1 is a novel tumor suppressor inhibiting tumor growth through deregulation of G1/S checkpoint in human colorectal carcinoma." Current Molecular Medicine 18, no. 1 (January 1, 2018): 25-35. Full Text
  - Mao, K, and Yan, H. "Precise medicine and individualized diagnosis and treatment of bladder cancer." Chinese Journal of Cancer Biotherapy 25, no. 1 (January 1, 2018): 17-22. Full Text
  - Waitkus, MS, Pirozzi, CJ, Moure, CJ, Diplas, BH, Hansen, LJ, Carpenter, AB, Yang, R, Wang, Z, Ingram, BO, Karoly, ED, Mohney, RP, Spasojevic, I, McLendon, RE, Friedman, HS, He, Y, Bigner, DD, and Yan, H. "Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities." Cancer Research 78, no. 1 (January 2018): 36-50. Full Text
  - Yang, R, Chen, LH, Hansen, LJ, Carpenter, AB, Moure, CJ, Liu, H, Pirozzi, CJ, Diplas, BH, Waitkus, MS, Greer, PK, Zhu, H, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation." Cancer Research 77, no. 22 (November 2017): 6097-6108. Full Text
  - Xu, C, Liu, X, Geng, Y, Bai, Q, Pan, C, Sun, Y, Chen, X, Yu, H, Wu, Y, Zhang, P, Wu, W, Wang, Y, Wu, Z, Zhang, J, Wang, Z, Yang, R, Lewis, J, Bigner, D, Zhao, F, He, Y, Yan, H, Shen, Q, and Zhang, L. "Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors." Oncotarget (July 28, 2017). Full Text
  - Pirozzi, CJ, Carpenter, AB, Waitkus, MS, Wang, CY, Zhu, H, Hansen, LJ, Chen, LH, Greer, PK, Feng, J, Wang, Y, Bock, CB, Fan, P, Spasojevic, I, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression." Molecular Cancer Research : Mcr 15, no. 5 (May 2017): 507-520. Full Text
  - Song, Z-J, Reitman, ZJ, Ma, Z-Y, Chen, J-H, Zhang, Q-L, Shou, X-F, Huang, C-X, Wang, Y-F, Li, S-Q, Mao, Y, Zhou, L-F, Lian, B-F, Yan, H, Shi, Y-Y, and Zhao, Y. "The genome-wide mutational landscape of pituitary adenomas." Cell Research 26, no. 11 (November 2016): 1255-1259. (Letter) Full Text
  - Chitneni, SK, Reitman, ZJ, Gooden, DM, Yan, H, and Zalutsky, MR. "Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs." European journal of medicinal chemistry 119 (August 2016): 218-230. Full Text Open Access Copy
  - Lu, Z, Sheng, J, Zhang, Y, Deng, J, Li, Y, Lu, A, Zhang, J, Yu, H, Zhang, M, Xiong, Z, Yan, H, Diplas, BH, Lu, Y, and Liu, B. "Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles." The Journal of Pathology 239, no. 1 (May 2016): 72-83. Full Text
  - Waitkus, MS, Diplas, BH, and Yan, H. "Isocitrate dehydrogenase mutations in gliomas." Neuro Oncology 18, no. 1 (January 2016): 16-26. (Review) Full Text
  - Huang, D-S, Tao, H-Q, He, X-J, Long, M, Yu, S, Xia, Y-J, Wei, Z, Xiong, Z, Jones, S, He, Y, Yan, H, and Wang, X. "Prevalence of deleterious ATM germline mutations in gastric cancer patients." Oncotarget 6, no. 38 (December 2015): 40953-40958. Full Text
  - Feng, J, Hao, S, Pan, C, Wang, Y, Wu, Z, Zhang, J, Yan, H, Zhang, L, and Wan, H. "The H3.3 K27M mutation results in a poorer prognosis in brainstem gliomas than thalamic gliomas in adults." Human Pathology 46, no. 11 (November 2015): 1626-1632. Full Text
  - Zhang, Z-Y, Chan, AK-Y, Ding, X-J, Qin, Z-Y, Hong, CS, Chen, L-C, Zhang, X, Zhao, F-P, Wang, Y, Wang, Y, Zhou, L-F, Zhuang, Z, Ng, H-K, Yan, H, Yao, Y, and Mao, Y. "TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas." Oncotarget 6, no. 28 (September 2015): 24871-24883. Full Text
  - Gurzadyan, VG, Yan, H, Vlahovic, G, Kashin, A, Killela, P, Reitman, Z, Sargsyan, S, Yegorian, G, Milledge, G, and Vlahovic, B. "Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis." Royal Society open science 2, no. 8 (August 26, 2015): 150143-. Full Text
  - Huang, D-S, Wang, Z, He, X-J, Diplas, BH, Yang, R, Killela, PJ, Meng, Q, Ye, Z-Y, Wang, W, Jiang, X-T, Xu, L, He, X-L, Zhao, Z-S, Xu, W-J, Wang, H-J, Ma, Y-Y, Xia, Y-J, Li, L, Zhang, R-X, Jin, T, Zhao, Z-K, Xu, J, Yu, S, Wu, F, Liang, J, Wang, S, Jiao, Y, Yan, H, and Tao, H-Q. "Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation." European journal of cancer (Oxford, England : 1990) 51, no. 8 (May 2015): 969-976. Full Text
  - Chen, P, Yan, H, Tian, Y, Xun, Y, Shi, L, Bao, R, Zhang, H, Chen, G, Yang, C, Sun, S, Wang, Y, Liu, L, Zhou, Y, Zhang, C, Wang, X, Wen, Y, Bian, Y, and Du, H. "Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease." Scientific reports 5 (January 2015): 8162-. Full Text
  - Reitman, ZJ, Sinenko, SA, Spana, EP, and Yan, H. "Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila." Blood 125, no. 2 (January 2015): 336-345. Full Text
  - Feng, H, Lopez, GY, Kim, CK, Alvarez, A, Duncan, CG, Nishikawa, R, Nagane, M, Su, A-JA, Auron, PE, Hedberg, ML, Wang, L, Raizer, JJ, Kessler, JA, Parsa, AT, Gao, W-Q, Kim, S-H, Minata, M, Nakano, I, Grandis, JR, McLendon, RE, Bigner, DD, Lin, H-K, Furnari, FB, Cavenee, WK, Hu, B, Yan, H, and Cheng, S-Y. "EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis." The Journal of Clinical Investigation 124, no. 9 (September 2014): 3741-3756. Full Text Open Access Copy
  - Feng, H, Lopez, GY, Kim, CK, Alvarez, A, Duncan, CG, Nishikawa, R, Nagane, M, Su, A-JA, Auron, PE, Hedberg, ML, Wang, L, Raizer, JJ, Kessler, JA, Parsa, AT, Gao, W-Q, Kim, S-H, Minata, M, Nakano, I, Grandis, JR, McLendon, RE, Bigner, DD, Lin, H-K, Furnari, FB, Cavenee, WK, Hu, B, Yan, H, and Cheng, S-Y. "EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis." JOURNAL OF CLINICAL INVESTIGATION 124, no. 9 (September 2014): 3741-3756. Full Text Link to Item
  - Reitman, ZJ, Duncan, CG, Poteet, E, Winters, A, Yan, L-J, Gooden, DM, Spasojevic, I, Boros, LG, Yang, S-H, and Yan, H. "Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia." The Journal of Biological Chemistry 289, no. 34 (August 2014): 23318-23328. Full Text
  - Zhang, L, Chen, LH, Wan, H, Yang, R, Wang, Z, Feng, J, Yang, S, Jones, S, Wang, S, Zhou, W, Zhu, H, Killela, PJ, Zhang, J, Wu, Z, Li, G, Hao, S, Wang, Y, Webb, JB, Friedman, HS, Friedman, AH, McLendon, RE, He, Y, Reitman, ZJ, Bigner, DD, and Yan, H. "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas." Nature genetics 46, no. 7 (July 2014): 726-730. Full Text
  - Killela, PJ, Pirozzi, CJ, Healy, P, Reitman, ZJ, Lipp, E, Rasheed, BA, Yang, R, Diplas, BH, Wang, Z, Greer, PK, Zhu, H, Wang, CY, Carpenter, AB, Friedman, H, Friedman, AH, Keir, ST, He, J, He, Y, McLendon, RE, Herndon, JE, Yan, H, and Bigner, DD. "Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas." Oncotarget 5, no. 6 (March 2014): 1515-1525. Full Text Open Access Copy
  - Killela, PJ, Pirozzi, CJ, Reitman, ZJ, Jones, S, Rasheed, BA, Lipp, E, Friedman, H, Friedman, AH, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "The genetic landscape of anaplastic astrocytoma." Oncotarget 5, no. 6 (March 2014): 1452-1457. Full Text
  - López, GY, Grant, GA, Fuchs, HE, Leithe, LG, Gururangan, S, Bigner, DD, Yan, H, McLendon, RE, and He, Y. "Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations." Neuropathology and Applied Neurobiology 40, no. 2 (February 2014): 217-220. (Letter) Full Text
  - Wortham, M, Guo, C, Zhang, M, Song, L, Lee, B-K, Iyer, VR, Furey, TS, Crawford, GE, Yan, H, and He, Y. "Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma." PloS one 9, no. 9 (January 2014): e107156-. Full Text Open Access Copy
  - Zhang, L, Chen, LH, Wan, H, Yang, R, Wang, Z, Feng, J, Yang, S, Jones, S, Wang, S, Zhou, W, Zhu, H, Killela, PJ, Zhang, J, Wu, Z, Li, G, Hao, S, Wang, Y, Webb, JB, Friedman, HS, Friedman, AH, McLendon, RE, He, Y, Reitman, ZJ, Bigner, DD, and Yan, H. "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas." Nature Genetics 46, no. 7 (January 1, 2014): 726-730. Full Text
  - Reitman, ZJ, Pirozzi, CJ, and Yan, H. "Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors." Acta Neuropathologica 126, no. 6 (December 2013): 789-792. Full Text
  - Reitman, ZJ, Pirozzi, CJ, and Yan, H. "Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors." Acta Neuropathologica 126, no. 6 (November 12, 2013): 789-792. (Review) Full Text
  - Guo, C, Chen, LH, Huang, Y, Chang, C-C, Wang, P, Pirozzi, CJ, Qin, X, Bao, X, Greer, PK, McLendon, RE, Yan, H, Keir, ST, Bigner, DD, and He, Y. "KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation." Oncotarget 4, no. 11 (November 2013): 2144-2153. Full Text
  - Frattini, V, Trifonov, V, Chan, JM, Castano, A, Lia, M, Abate, F, Keir, ST, Ji, AX, Zoppoli, P, Niola, F, Danussi, C, Dolgalev, I, Porrati, P, Pellegatta, S, Heguy, A, Gupta, G, Pisapia, DJ, Canoll, P, Bruce, JN, McLendon, RE, Yan, H, Aldape, K, Finocchiaro, G, Mikkelsen, T, Privé, GG, Bigner, DD, Lasorella, A, Rabadan, R, and Iavarone, A. "The integrated landscape of driver genomic alterations in glioblastoma." Nature Genetics 45, no. 10 (October 2013): 1141-1149. Full Text
  - Hodges, TR, Choi, BD, Bigner, DD, Yan, H, and Sampson, JH. "Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review." Journal of Neurosurgery 118, no. 6 (June 2013): 1176-1180. (Review) Full Text
  - Pirozzi, CJ, Reitman, ZJ, and Yan, H. "Releasing the block: setting differentiation free with mutant IDH inhibitors." Cancer Cell 23, no. 5 (May 2013): 570-572. Full Text
  - Bettegowda, C, Agrawal, N, Jiao, Y, Wang, Y, Wood, LD, Rodriguez, FJ, Hruban, RH, Gallia, GL, Binder, ZA, Riggins, CJ, Salmasi, V, Riggins, GJ, Reitman, ZJ, Rasheed, A, Keir, S, Shinjo, S, Marie, S, McLendon, R, Jallo, G, Vogelstein, B, Bigner, D, Yan, H, Kinzler, KW, and Papadopoulos, N. "Exomic sequencing of four rare central nervous system tumor types." Oncotarget 4, no. 4 (April 2013): 572-583. Full Text
  - Killela, PJ, Reitman, ZJ, Jiao, Y, Bettegowda, C, Agrawal, N, Diaz, LA, Friedman, AH, Friedman, H, Gallia, GL, Giovanella, BC, Grollman, AP, He, T-C, He, Y, Hruban, RH, Jallo, GI, Mandahl, N, Meeker, AK, Mertens, F, Netto, GJ, Rasheed, BA, Riggins, GJ, Rosenquist, TA, Schiffman, M, Shih, I-M, Theodorescu, D, Torbenson, MS, Velculescu, VE, Wang, T-L, Wentzensen, N, Wood, LD, Zhang, M, McLendon, RE, Bigner, DD, Kinzler, KW, Vogelstein, B, Papadopoulos, N, and Yan, H. "TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal." Proceedings of the National Academy of Sciences of the United States of America 110, no. 15 (April 2013): 6021-6026. Full Text
  - Poteet, E, Choudhury, GR, Winters, A, Li, W, Ryou, M-G, Liu, R, Tang, L, Ghorpade, A, Wen, Y, Yuan, F, Keir, ST, Yan, H, Bigner, DD, Simpkins, JW, and Yang, S-H. "Reversing the Warburg effect as a treatment for glioblastoma." The Journal of Biological Chemistry 288, no. 13 (March 2013): 9153-9164. Full Text
  - Frattini, V, Trifonov, V, Chan, JM, Castano, A, Lia, M, Abate, F, Keir, ST, Ji, AX, Zoppoli, P, Niola, F, and al, E. "The integrated landscape of driver genomic alterations in glioblastoma." Nature Genetics 45, no. 10 (2013): 1141-1149. Full Text
  - Jin, G, Reitman, ZJ, Duncan, CG, Spasojevic, I, Gooden, DM, Rasheed, BA, Yang, R, Lopez, GY, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas." Cancer Research 73, no. 2 (January 2013): 496-501. Full Text Open Access Copy
  - Duncan, CG, Barwick, BG, Jin, G, Rago, C, Kapoor-Vazirani, P, Powell, DR, Chi, J-T, Bigner, DD, Vertino, PM, and Yan, H. "A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation." Genome Research 22, no. 12 (December 2012): 2339-2355. Full Text
  - Reitman, ZJ, Choi, BD, Spasojevic, I, Bigner, DD, Sampson, JH, and Yan, H. "Enzyme redesign guided by cancer-derived IDH1 mutations." Nature Chemical Biology 8, no. 11 (November 2012): 887-889. Full Text
  - Guo, C, Chang, C-C, Wortham, M, Chen, LH, Kernagis, DN, Qin, X, Cho, Y-W, Chi, J-T, Grant, GA, McLendon, RE, Yan, H, Ge, K, Papadopoulos, N, Bigner, DD, and He, Y. "Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways." Proc Natl Acad Sci U S A 109, no. 43 (October 23, 2012): 17603-17608. Full Text Link to Item
  - Jin, G, Pirozzi, CJ, Chen, LH, Lopez, GY, Duncan, CG, Feng, J, Spasojevic, I, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 is required for IDH1 mutated tumor cell growth." Oncotarget 3, no. 8 (August 2012): 774-782. Full Text Open Access Copy
  - Jiao, Y, Killela, PJ, Reitman, ZJ, Rasheed, AB, Heaphy, CM, de Wilde, RF, Rodriguez, FJ, Rosemberg, S, Oba-Shinjo, SM, Nagahashi Marie, SK, Bettegowda, C, Agrawal, N, Lipp, E, Pirozzi, C, Lopez, G, He, Y, Friedman, H, Friedman, AH, Riggins, GJ, Holdhoff, M, Burger, P, McLendon, R, Bigner, DD, Vogelstein, B, Meeker, AK, Kinzler, KW, Papadopoulos, N, Diaz, LA, and Yan, H. "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas." Oncotarget 3, no. 7 (July 2012): 709-722. Full Text Open Access Copy
  - Wortham, M, and Yan, H. "Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells." Cancer Discovery 2, no. 6 (June 2012): 492-494. Full Text
  - Li, M, Lockwood, W, Zielenska, M, Northcott, P, Ra, YS, Bouffet, E, Yoshimoto, M, Rutka, JT, Yan, H, Taylor, MD, Eberhart, C, Hawkins, CE, Lam, W, Squire, JA, and Huang, A. "Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor." Cancer Genetics 205, no. 5 (May 2012): 220-231. Full Text
  - Koivunen, P, Lee, S, Duncan, CG, Lopez, G, Lu, G, Ramkissoon, S, Losman, JA, Joensuu, P, Bergmann, U, Gross, S, Travins, J, Weiss, S, Looper, R, Ligon, KL, Verhaak, RGW, Yan, H, and Kaelin, WG. "Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation." Nature 483, no. 7390 (February 15, 2012): 484-488. Full Text Open Access Copy
  - Jones, S, Li, M, Parsons, DW, Zhang, X, Wesseling, J, Kristel, P, Schmidt, MK, Markowitz, S, Yan, H, Bigner, D, Hruban, RH, Eshleman, JR, Iacobuzio-Donahue, CA, Goggins, M, Maitra, A, Malek, SN, Powell, S, Vogelstein, B, Kinzler, KW, Velculescu, VE, and Papadopoulos, N. "Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types." Human Mutation 33, no. 1 (January 2012): 100-103. Full Text
  - Wortham, M, Jin, G, Sun, JL, Bigner, DD, He, Y, and Yan, H. "Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells." Plos One 7, no. 4 (January 2012): e36211-null. Full Text
  - Guo, C, Pirozzi, CJ, Lopez, GY, and Yan, H. "Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target." Current Opinion in Neurology 24, no. 6 (December 2011): 648-652. (Review) Full Text Open Access Copy
  - Bettegowda, C, Agrawal, N, Jiao, Y, Sausen, M, Wood, LD, Hruban, RH, Rodriguez, FJ, Cahill, DP, McLendon, R, Riggins, G, Velculescu, VE, Oba-Shinjo, SM, Marie, SKN, Vogelstein, B, Bigner, D, Yan, H, Papadopoulos, N, and Kinzler, KW. "Mutations in CIC and FUBP1 contribute to human oligodendroglioma." Science (New York, N.Y.) 333, no. 6048 (September 2011): 1453-1455. Full Text
  - Heaphy, CM, de Wilde, RF, Jiao, Y, Klein, AP, Edil, BH, Shi, C, Bettegowda, C, Rodriguez, FJ, Eberhart, CG, Hebbar, S, Offerhaus, GJ, McLendon, R, Rasheed, BA, He, Y, Yan, H, Bigner, DD, Oba-Shinjo, SM, Marie, SKN, Riggins, GJ, Kinzler, KW, Vogelstein, B, Hruban, RH, Maitra, A, Papadopoulos, N, and Meeker, AK. "Altered telomeres in tumors with ATRX and DAXX mutations." Science (New York, N.Y.) 333, no. 6041 (July 2011): 425-null. Full Text
  - Duncan, CG, and Yan, H. "Genomic alterations and the pathogenesis of glioblastoma." Cell Cycle 10, no. 8 (April 15, 2011): 1174-1175. Full Text Link to Item
  - Jin, G, Reitman, ZJ, Spasojevic, I, Batinic-Haberle, I, Yang, J, Schmidt-Kittler, O, Bigner, DD, and Yan, H. "2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations." Plos One 6, no. 2 (February 4, 2011): e16812-null. Full Text
  - Reitman, ZJ, Jin, G, Karoly, ED, Spasojevic, I, Yang, J, Kinzler, KW, He, Y, Bigner, DD, Vogelstein, B, and Yan, H. "Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome." Proceedings of the National Academy of Sciences of the United States of America 108, no. 8 (February 2, 2011): 3270-3275. Full Text
  - Parsons, DW, Li, M, Zhang, X, Jones, S, Leary, RJ, Lin, JC-H, Boca, SM, Carter, H, Samayoa, J, Bettegowda, C, Gallia, GL, Jallo, GI, Binder, ZA, Nikolsky, Y, Hartigan, J, Smith, DR, Gerhard, DS, Fults, DW, VandenBerg, S, Berger, MS, Marie, SKN, Shinjo, SMO, Clara, C, Phillips, PC, Minturn, JE, Biegel, JA, Judkins, AR, Resnick, AC, Storm, PB, Curran, T, He, Y, Rasheed, BA, Friedman, HS, Keir, ST, McLendon, R, Northcott, PA, Taylor, MD, Burger, PC, Riggins, GJ, Karchin, R, Parmigiani, G, Bigner, DD, Yan, H, Papadopoulos, N, Vogelstein, B, Kinzler, KW, and Velculescu, VE. "The genetic landscape of the childhood cancer medulloblastoma." Science (New York, N.Y.) 331, no. 6016 (January 2011): 435-439. Full Text
  - Jin, G, Cook, S, Cui, B, Chen, WC, Keir, ST, Killela, P, Di, C, Payne, CA, Gregory, SG, McLendon, R, Bigner, DD, and Yan, H. "HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea." Neuro Oncology 12, no. 9 (September 2010): 956-966. Full Text
  - Duncan, CG, Killela, PJ, Payne, CA, Lampson, B, Chen, WC, Liu, J, Solomon, D, Waldman, T, Towers, AJ, Gregory, SG, McDonald, KL, McLendon, RE, Bigner, DD, and Yan, H. "Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes." Oncotarget 1, no. 4 (August 2010): 265-277. Full Text
  - Lopez, GY, Reitman, ZJ, Solomon, D, Waldman, T, Bigner, DD, McLendon, RE, Rosenberg, SA, Samuels, Y, and Yan, H. "IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain." Biochemical and Biophysical Research Communications 398, no. 3 (July 13, 2010): 585-587. Full Text Open Access Copy
  - Reitman, ZJ, Olby, NJ, Mariani, CL, Thomas, R, Breen, M, Bigner, DD, McLendon, RE, and Yan, H. "IDH1 and IDH2 hotspot mutations are not found in canine glioma." Int J Cancer 127, no. 1 (July 1, 2010): 245-246. (Letter) Full Text Link to Item
  - Reitman, ZJ, and Yan, H. "Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism." Journal of the National Cancer Institute 102, no. 13 (July 2010): 932-941. (Review) Full Text
  - Reitman, ZJ, Parsons, DW, and Yan, H. "IDH1 and IDH2: not your typical oncogenes." Cancer Cell 17, no. 3 (March 2010): 215-216. Full Text
  - Adamson, DC, Shi, Q, Wortham, M, Northcott, PA, Di, C, Duncan, CG, Li, J, McLendon, RE, Bigner, DD, Taylor, MD, and Yan, H. "OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas." Cancer Research 70, no. 1 (January 2010): 181-191. Full Text
  - Nakahara, Y, Northcott, PA, Li, M, Kongkham, PN, Smith, C, Yan, H, Croul, S, Ra, Y-S, Eberhart, C, Huang, A, Bigner, D, Grajkowska, W, Van Meter, T, Rutka, JT, and Taylor, MD. "Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma." Neoplasia 12, no. 1 (January 2010): 20-27. Link to Item
  - Kato, Y, Jin, G, Kuan, C-T, McLendon, RE, Yan, H, and Bigner, DD. "A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation." Biochemical and Biophysical Research Communications 390, no. 3 (December 2009): 547-551. Full Text
  - Lu, Z, Zhou, L, Killela, P, Rasheed, AB, Di, C, Poe, WE, McLendon, RE, Bigner, DD, Nicchitta, C, and Yan, H. "Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress." Cancer Research 69, no. 23 (December 2009): 9105-9111. Full Text
  - Yan, H, Bigner, DD, Velculescu, V, and Parsons, DW. "Mutant metabolic enzymes are at the origin of gliomas." Cancer Research 69, no. 24 (December 2009): 9157-9159. (Review) Full Text
  - Solomon, DA, Kim, J-S, Ressom, HW, Sibenaller, Z, Ryken, T, Jean, W, Bigner, D, Yan, H, and Waldman, T. "Sample type bias in the analysis of cancer genomes." Cancer Research 69, no. 14 (July 2009): 5630-5633. Full Text
  - Kanu, OO, Mehta, A, Di, C, Lin, N, Bortoff, K, Bigner, DD, Yan, H, and Adamson, DC. "Glioblastoma multiforme: a review of therapeutic targets." Expert Opin Ther Targets 13, no. 6 (June 2009): 701-718. (Review) Full Text Link to Item
  - Reitman, Z, and Yan, H. "The author and a colleague reply." New England Journal of Medicine 360, no. 21 (May 21, 2009): 2249-null. (Letter) Full Text
  - Duncan, CG, Leary, RJ, Lin, JC-H, Cummins, J, Di, C, Schaefer, CF, Wang, T-L, Riggins, GJ, Edwards, J, Bigner, D, Kopelovich, L, Vogelstein, B, Kinzler, KW, Velculescu, VE, and Yan, H. "Identification of microbial DNA in human cancer. (Published online)" BMC Med Genomics 2 (May 8, 2009): 22-. Full Text Link to Item
  - Kanu, OO, Hughes, B, Di, C, Lin, N, Fu, J, Bigner, DD, Yan, H, and Adamson, C. "Glioblastoma Multiforme Oncogenomics and Signaling Pathways." Clinical Medicine. Oncology 3 (April 2009): 39-52.
  - Yan, H, Parsons, DW, Jin, G, McLendon, R, Rasheed, BA, Yuan, W, Kos, I, Batinic-Haberle, I, Jones, S, Riggins, GJ, Friedman, H, Friedman, A, Reardon, D, Herndon, J, Kinzler, KW, Velculescu, VE, Vogelstein, B, and Bigner, DD. "IDH1 and IDH2 mutations in gliomas." The New England Journal of Medicine 360, no. 8 (February 2009): 765-773. Full Text
  - Solomon, DA, Kim, J-S, Cronin, JC, Sibenaller, Z, Ryken, T, Rosenberg, SA, Ressom, H, Jean, W, Bigner, D, Yan, H, Samuels, Y, and Waldman, T. "Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma." Cancer Res 68, no. 24 (December 15, 2008): 10300-10306. Full Text Link to Item
  - Parsons, DW, Jones, S, Zhang, X, Lin, JC-H, Leary, RJ, Angenendt, P, Mankoo, P, Carter, H, Siu, I-M, Gallia, GL, Olivi, A, McLendon, R, Rasheed, BA, Keir, S, Nikolskaya, T, Nikolsky, Y, Busam, DA, Tekleab, H, Diaz, LA, Hartigan, J, Smith, DR, Strausberg, RL, Marie, SKN, Shinjo, SMO, Yan, H, Riggins, GJ, Bigner, DD, Karchin, R, Papadopoulos, N, Parmigiani, G, Vogelstein, B, Velculescu, VE, and Kinzler, KW. "An integrated genomic analysis of human glioblastoma multiforme." Science (New York, N.Y.) 321, no. 5897 (September 4, 2008): 1807-1812. Full Text
  - Solomon, DA, Kim, J-S, Jenkins, S, Ressom, H, Huang, M, Coppa, N, Mabanta, L, Bigner, D, Yan, H, Jean, W, and Waldman, T. "Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme." Cancer Research 68, no. 8 (April 2008): 2564-2569. Full Text
  - Wood, LD, Calhoun, ES, Silliman, N, Ptak, J, Szabo, S, Powell, SM, Riggins, GJ, Wang, T-L, Yan, H, Gazdar, A, Kern, SE, Pennacchio, L, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers." Human Mutation 27, no. 10 (October 2006): 1060-1061. Full Text
  - Parrett, TJ, and Yan, H. "Digital karyotyping technology: exploring the cancer genome." Expert Rev Mol Diagn 5, no. 6 (November 2005): 917-925. (Review) Full Text Link to Item
  - Di, C, Liao, S, Adamson, DC, Parrett, TJ, Broderick, DK, Shi, Q, Lengauer, C, Cummins, JM, Velculescu, VE, Fults, DW, McLendon, RE, Bigner, DD, and Yan, H. "Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid." Cancer Research 65, no. 3 (February 2005): 919-924.
  - Yan, H. "Snapshot of the allele-specific variation in human gene expression." Methods Mol Biol 311 (2005): 31-38. Full Text Link to Item
  - Rich, JN, Rasheed, BKA, and Yan, H. "EGFR mutations and sensitivity to gefitinib." The New England Journal of Medicine 351, no. 12 (September 2004): 1260-1261. (Letter) Full Text
  - Sorscher, SM. "EGFR mutations and sensitivity to gefitinib." The New England Journal of Medicine 351, no. 12 (September 2004): 1260-1261. (Letter) Full Text
  - Broderick, DK, Di, C, Parrett, TJ, Samuels, YR, Cummins, JM, McLendon, RE, Fults, DW, Velculescu, VE, Bigner, DD, and Yan, H. "Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas." Cancer Research 64, no. 15 (August 2004): 5048-5050. Full Text
  - Wang, Z, Shen, D, Parsons, DW, Bardelli, A, Sager, J, Szabo, S, Ptak, J, Silliman, N, Peters, BA, van der Heijden, MS, Parmigiani, G, Yan, H, Wang, T-L, Riggins, G, Powell, SM, Willson, JKV, Markowitz, S, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "Mutational analysis of the tyrosine phosphatome in colorectal cancers." Science (New York, N.Y.) 304, no. 5674 (May 2004): 1164-1166. Full Text
  - Samuels, Y, Wang, Z, Bardelli, A, Silliman, N, Ptak, J, Szabo, S, Yan, H, Gazdar, A, Powell, SM, Riggins, GJ, Willson, JKV, Markowitz, S, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "High frequency of mutations of the PIK3CA gene in human cancers." Science (New York, N.Y.) 304, no. 5670 (April 2004): 554-null. Full Text
  - Butz, JA, Yan, H, Mikkilineni, V, and Edwards, JS. "Detection of allelic variations of human gene expression by polymerase colonies. (Published online)" BMC Genet 5 (February 16, 2004): 3-. Full Text Link to Item
  - Yan, H, and Zhou, W. "Allelic variations in gene expression." Curr Opin Oncol 16, no. 1 (January 2004): 39-43. (Review) Link to Item
  - Dressman, D, Yan, H, Traverso, G, Kinzler, KW, and Vogelstein, B. "Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations." Proceedings of the National Academy of Sciences of the United States of America 100, no. 15 (July 11, 2003): 8817-8822. Full Text
  - Nakagawa, H, Yan, H, Lockman, J, Hampel, H, Kinzler, KW, Vogelstein, B, and De La Chapelle, A. "Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements." Cancer Res 62, no. 16 (August 15, 2002): 4579-4582. Link to Item
  - Yan, H, Yuan, W, Velculescu, VE, Vogelstein, B, and Kinzler, KW. "Allelic variation in human gene expression." Science (New York, N.Y.) 297, no. 5584 (August 2002): 1143-null. Full Text
  - Nguyen, V-P, Saleh, AZM, Arch, AE, Yan, H, Piazza, F, Kim, J, and Krolewski, JJ. "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling." J Biol Chem 277, no. 12 (March 22, 2002): 9713-9721. Full Text Link to Item
  - Yan, H, Dobbie, Z, Gruber, SB, Markowitz, S, Romans, K, Giardiello, FM, Kinzler, KW, and Vogelstein, B. "Small changes in expression affect predisposition to tumorigenesis." Nature Genetics 30, no. 1 (January 2002): 25-26. Full Text
  - Liu, T, Yan, H, Kuismanen, S, Percesepe, A, Bisgaard, ML, Pedroni, M, Benatti, P, Kinzler, KW, Vogelstein, B, Ponz de Leon, M, Peltomäki, P, and Lindblom, A. "The role of hPMS1 and hPMS2 in predisposing to colorectal cancer." Cancer Res 61, no. 21 (November 1, 2001): 7798-7802. Link to Item
  - Marra, G, D'Atri, S, Yan, H, Perrera, C, Cannavo', E, Vogelstein, B, and Jiricny, J. "Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes." Cancer Res 61, no. 21 (November 1, 2001): 7719-7721. Link to Item
  - Langer, S, Jentsch, I, Gangnus, R, Yan, H, Lengauer, C, and Speicher, MR. "Facilitating haplotype analysis by fully automated analysis of all chromosomes in human-mouse hybrid cell lines." Cytogenet Cell Genet 93, no. 1-2 (2001): 11-15. Full Text Link to Item
  - Yan, H, Kinzler, KW, and Vogelstein, B. "Tech.sight. Genetic testing--present and future." Science 289, no. 5486 (September 15, 2000): 1890-1892. (Review) Link to Item
  - Yan, H, Kinzler, KW, and Vogelstein, B. "Genetic testing - Present and future." Science 289, no. 5486 (September 15, 2000): 1890-1892. Full Text
  - Yan, H, Papadopoulos, N, Marra, G, Perrera, C, Jiricny, J, Boland, CR, Lynch, HT, Chadwick, RB, de la Chapelle, A, Berg, K, Eshleman, JR, Yuan, W, Markowitz, S, Laken, SJ, Lengauer, C, Kinzler, KW, and Vogelstein, B. "Conversion of diploidy to haploidy." Nature 403, no. 6771 (February 2000): 723-724. Full Text
  - Yan, H, Piazza, F, Krishnan, K, Pine, R, and Krolewski, JJ. "Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase." J Biol Chem 273, no. 7 (February 13, 1998): 4046-4051. Link to Item
  - Yan, H, Piazza, F, Krishnan, K, Pine, R, and Krolewski, JJ. "Definition of the interferon-α receptor-binding domain on the TYK2 kinase." Journal of Biological Chemistry 273, no. 7 (February 13, 1998): 4045-4051.
  - Domanski, P, Fish, E, Nadeau, OW, Witte, M, Platanias, LC, Yan, H, Krolewski, J, Pitha, P, and Colamonici, OR. "A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state." J Biol Chem 272, no. 42 (October 17, 1997): 26388-26393. Link to Item
  - Yan, H, Krishnan, K, Lim, JTE, and Krolewski, J. "Interferon a receptor 1 subunit (IFNaRI) binds to TYK2 and acts as a docking site for STAT2." Faseb Journal 10, no. 6 (December 1, 1996).
  - Krishnan, K, Yan, H, Lim, JT, and Krolewski, JJ. "Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation." Oncogene 13, no. 1 (July 1996): 125-133.
  - Yan, H, Krishnan, K, Lim, JT, Contillo, LG, and Krolewski, JJ. "Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction." Mol Cell Biol 16, no. 5 (May 1996): 2074-2082. Link to Item
  - Davis, E, Krishnan, K, Yan, H, Newcomb, EW, and Krolewski, JJ. "A mutant form of p135tyk2, an interferon-alpha inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells." Leukemia 10, no. 3 (March 1996): 543-551. Link to Item
  - Gupta, S, Yan, H, Wong, LH, Ralph, S, Krolewski, J, and Schindler, C. "The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals." The Embo Journal 15, no. 5 (March 1996): 1075-1084. Full Text
  - Yan, H, Krishnan, K, Greenlund, AC, Gupta, S, Lim, JT, Schreiber, RD, Schindler, CW, and Krolewski, JJ. "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein." The Embo Journal 15, no. 5 (March 1996): 1064-1074. Full Text
  - Domanski, P, Yan, H, Witte, MM, Krolewski, J, and Colamonici, OR. "Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase." FEBS Lett 374, no. 3 (November 6, 1995): 317-322. Link to Item
  - Yan, H, Lim, JT, Contillo, LG, and Krolewski, JJ. "Glutathione S-transferase fusion proteins mimic receptor dimerization in permeabilized cells." Anal Biochem 231, no. 2 (November 1, 1995): 455-458. Full Text Link to Item
  - Greenlund, AC, Morales, MO, Viviano, BL, Yan, H, Krolewski, J, and Schreiber, RD. "Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process." Immunity 2, no. 6 (June 1995): 677-687. Full Text
  - Colamonici, O, Yan, H, Domanski, P, Handa, R, Smalley, D, Mullersman, J, Witte, M, Krishnan, K, and Krolewski, J. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase." Mol Cell Biol 14, no. 12 (December 1994): 8133-8142. Link to Item
  - Colamonici, OR, Uyttendaele, H, Domanski, P, Yan, H, and Krolewski, JJ. "p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor." J Biol Chem 269, no. 5 (February 4, 1994): 3518-3522. Link to Item
- Book Sections
  - Pirozzi, CJ, Carpenter, AB, Hennika, T, Becher, OJ, and Yan, H. "Tumor-Specific Mutations in Gliomas and their Implications for Immunotherapy." In Translational Immunotherapy of Brain Tumors, 83-107. March 2, 2017. Full Text
  - Hansen, LJ, Diplas, BH, Becher, O, and Yan, H. "Genetics of glioma." In The Duke Glioma Handbook: Pathology, Diagnosis, and Management, 1-23. March 31, 2016. Full Text
  - López, GY, Samsky, M, Jones, R, Adamson, C, and Yan, H. "Genetic alterations in glioblastoma multiforme." In Systems Biology of Cancer, 323-344. January 1, 2015. Full Text
- Conference Papers
  - Yang, CJ, Tang, N, Yan, H, Chakravarty, S, Li, D, and Chen, RT. "193nm Lithography fabricated high sensitivity photonic crystal microcavity biosensors for plasma protein detection in patients with pancreatic cancer." August 10, 2015.
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