Hai Yan | Scholars@Duke

Hai Yan
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine

Our research activities center on the molecular genetics and biology of cancer with a focus on the identification, characterization, and therapeutic targeting of driver mutations involved in the genesis and progression of brain cancers. Gliomas are the most common type of primary brain tumor. Through genomic studies, we have identified mutations in IDH1 and IDH2 in 70% of progressive malignant gliomas. These are somatic missense mutations that alter a conserved arginine residue and gain a neomorphic activity. A new metabolite produced by the glioma cells impacts on chromatin modulation and genome methylation. Malignant cells must maintain their telomeres. We identified several different tumor types exhibiting a high frequency of TERT promoter mutations, including several glioma subtypes. Conversely, we found a low frequency of TERT promoter mutations in many common epithelial tumors. In gliomas, we found that TERT promoter mutations were mutually exclusive with ATRX alterations, which are associated with activation of the ALT pathway for telomere maintenance. These findings show that TERT promoter mutations are frequent driver events in many human cancers, particularly those that arise from tissues with low rates of self-renewal. Our long-term goal is to develop a novel molecular-based glioma classification system and a targeted therapy on the basis of IDH1 and TERT mutations. To provide novel avenues for development of anticancer therapeutics, studies involving cell line and animal models, enzymatic study, metabolome and epigenome, are being investigated to determine the consequences of IDH1 and TERT mutations on cancer cells.

Current Appointments & Affiliations

Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology, Clinical Science Departments 2014
Professor of Pathology, Pathology, Clinical Science Departments 2012
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003

Contact Information

199B MSRB, Research Drive, Durham, NC 27710
Duke Box 3156, Department of Pathology, Durham, NC 27710
hai.yan@duke.edu (919) 668-7850

Background
Education, Training, & Certifications
- Faculty, Research Associate, Molecular Genetics, Thomas Jefferson University 2002 - 2003
- Research Associate, Howard Hughes Institute, Johns Hopkins University 1997 - 2002
- Ph.D., Columbia University 1997
- M.D., Beijing Medical University (China) 1991
Duke Appointment History
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2011 - 2012
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2009 - 2011
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2003 - 2009
- Instructor, Temporary of Pathology, Pathology, Clinical Science Departments 2003
Recognition
In the News
- JUN 2, 2014
  
  Newly Identified Brain Cancer Mutation Will Aid Drug Development
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Book Sections
  - López, GY, Samsky, M, Jones, R, Adamson, C, and Yan, H. "Genetic alterations in glioblastoma multiforme." In Systems Biology of Cancer, 323-344. January 1, 2015. Full Text
- Conference Papers
  - Yang, CJ, Tang, N, Yan, H, Chakravarty, S, Li, D, and Chen, RT. "193nm Lithography fabricated high sensitivity photonic crystal microcavity biosensors for plasma protein detection in patients with pancreatic cancer." August 10, 2015.
  - He, Y, Lopez, G, Grant, G, Fuchs, H, Leithe, L, Gururangan, S, Bigner, D, Yan, H, and Mclendon, R. "CLINICAL PATHOLOGIC DESCRIPTION OF THREE PEDIATRIC MEDULLOBLASTOMA CASES WITH MLL2/3 GENE MUTATIONS." May 2011. Link to Item
- Journal Articles
  - Pirozzi, CJ, Carpenter, AB, Waitkus, MS, Wang, CY, Zhu, H, Hansen, LJ, Chen, LH, Greer, PK, Feng, J, Wang, Y, Bock, CB, Fan, P, Spasojevic, I, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression." Molecular cancer research : MCR 15, no. 5 (May 2017): 507-520. Full Text
  - Song, Z-J, Reitman, ZJ, Ma, Z-Y, Chen, J-H, Zhang, Q-L, Shou, X-F, Huang, C-X, Wang, Y-F, Li, S-Q, Mao, Y, Zhou, L-F, Lian, B-F, Yan, H, Shi, Y-Y, and Zhao, Y. "The genome-wide mutational landscape of pituitary adenomas." Cell research 26, no. 11 (November 2016): 1255-1259. (letter) Full Text
  - Chitneni, SK, Reitman, ZJ, Gooden, DM, Yan, H, and Zalutsky, MR. "Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs." European journal of medicinal chemistry 119 (August 2016): 218-230. Full Text Open Access Copy
  - Lu, Z, Sheng, J, Zhang, Y, Deng, J, Li, Y, Lu, A, Zhang, J, Yu, H, Zhang, M, Xiong, Z, Yan, H, Diplas, BH, Lu, Y, and Liu, B. "Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles." The Journal of pathology 239, no. 1 (May 2016): 72-83. Full Text
  - Waitkus, MS, Diplas, BH, and Yan, H. "Isocitrate dehydrogenase mutations in gliomas." Neuro-oncology 18, no. 1 (January 2016): 16-26. (Review) Full Text
  - Huang, D-S, Tao, H-Q, He, X-J, Long, M, Yu, S, Xia, Y-J, Wei, Z, Xiong, Z, Jones, S, He, Y, Yan, H, and Wang, X. "Prevalence of deleterious ATM germline mutations in gastric cancer patients." Oncotarget 6, no. 38 (December 2015): 40953-40958. Full Text
  - Feng, J, Hao, S, Pan, C, Wang, Y, Wu, Z, Zhang, J, Yan, H, Zhang, L, and Wan, H. "The H3.3 K27M mutation results in a poorer prognosis in brainstem gliomas than thalamic gliomas in adults." Human pathology 46, no. 11 (November 2015): 1626-1632. Full Text
  - Zhang, Z-Y, Chan, AK-Y, Ding, X-J, Qin, Z-Y, Hong, CS, Chen, L-C, Zhang, X, Zhao, F-P, Wang, Y, Wang, Y, Zhou, L-F, Zhuang, Z, Ng, H-K, Yan, H, Yao, Y, and Mao, Y. "TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas." Oncotarget 6, no. 28 (September 2015): 24871-24883. Full Text
  - Gurzadyan, VG, Yan, H, Vlahovic, G, Kashin, A, Killela, P, Reitman, Z, Sargsyan, S, Yegorian, G, Milledge, G, and Vlahovic, B. "Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis." Royal Society open science 2, no. 8 (August 26, 2015): 150143-. Full Text
  - Huang, D-S, Wang, Z, He, X-J, Diplas, BH, Yang, R, Killela, PJ, Meng, Q, Ye, Z-Y, Wang, W, Jiang, X-T, Xu, L, He, X-L, Zhao, Z-S, Xu, W-J, Wang, H-J, Ma, Y-Y, Xia, Y-J, Li, L, Zhang, R-X, Jin, T, Zhao, Z-K, Xu, J, Yu, S, Wu, F, Liang, J, Wang, S, Jiao, Y, Yan, H, and Tao, H-Q. "Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation." European journal of cancer (Oxford, England : 1990) 51, no. 8 (May 2015): 969-976. Full Text
  - Chen, P, Yan, H, Tian, Y, Xun, Y, Shi, L, Bao, R, Zhang, H, Chen, G, Yang, C, Sun, S, Wang, Y, Liu, L, Zhou, Y, Zhang, C, Wang, X, Wen, Y, Bian, Y, and Du, H. "Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease." Scientific reports 5 (January 2015): 8162-. Full Text
  - Reitman, ZJ, Sinenko, SA, Spana, EP, and Yan, H. "Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila." Blood 125, no. 2 (January 2015): 336-345. Full Text
  - Feng, H, Lopez, GY, Kim, CK, Alvarez, A, Duncan, CG, Nishikawa, R, Nagane, M, Su, A-JA, Auron, PE, Hedberg, ML, Wang, L, Raizer, JJ, Kessler, JA, Parsa, AT, Gao, W-Q, Kim, S-H, Minata, M, Nakano, I, Grandis, JR, McLendon, RE, Bigner, DD, Lin, H-K, Furnari, FB, Cavenee, WK, Hu, B, Yan, H, and Cheng, S-Y. "EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis." The Journal of clinical investigation 124, no. 9 (September 2014): 3741-3756. Full Text
  - Feng, H, Lopez, GY, Kim, CK, Alvarez, A, Duncan, CG, Nishikawa, R, Nagane, M, Su, A-JA, Auron, PE, Hedberg, ML, Wang, L, Raizer, JJ, Kessler, JA, Parsa, AT, Gao, W-Q, Kim, S-H, Minata, M, Nakano, I, Grandis, JR, McLendon, RE, Bigner, DD, Lin, H-K, Furnari, FB, Cavenee, WK, Hu, B, Yan, H, and Cheng, S-Y. "EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis." JOURNAL OF CLINICAL INVESTIGATION 124, no. 9 (September 2014): 3741-3756. Full Text Link to Item
  - Reitman, ZJ, Duncan, CG, Poteet, E, Winters, A, Yan, L-J, Gooden, DM, Spasojevic, I, Boros, LG, Yang, S-H, and Yan, H. "Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia." The Journal of biological chemistry 289, no. 34 (August 2014): 23318-23328. Full Text
  - Zhang, L, Chen, LH, Wan, H, Yang, R, Wang, Z, Feng, J, Yang, S, Jones, S, Wang, S, Zhou, W, Zhu, H, Killela, PJ, Zhang, J, Wu, Z, Li, G, Hao, S, Wang, Y, Webb, JB, Friedman, HS, Friedman, AH, McLendon, RE, He, Y, Reitman, ZJ, Bigner, DD, and Yan, H. "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas." Nature genetics 46, no. 7 (July 2014): 726-730. Full Text
  - Zhang, L, Chen, LH, Wan, H, Yang, R, Wang, Z, Feng, J, Yang, S, Jones, S, Wang, S, Zhou, W, Zhu, H, Killela, PJ, Zhang, J, Wu, Z, Li, G, Hao, S, Wang, Y, Webb, JB, Friedman, HS, Friedman, AH, McLendon, RE, He, Y, Reitman, ZJ, Bigner, DD, and Yan, H. "Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas." Nature Genetics 46, no. 7 (June 1, 2014): 726-730. Full Text
  - Killela, PJ, Pirozzi, CJ, Reitman, ZJ, Jones, S, Rasheed, BA, Lipp, E, Friedman, H, Friedman, AH, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "The genetic landscape of anaplastic astrocytoma." Oncotarget 5, no. 6 (March 30, 2014): 1452-1457. Full Text Link to Item
  - Killela, PJ, Pirozzi, CJ, Healy, P, Reitman, ZJ, Lipp, E, Rasheed, BA, Yang, R, Diplas, BH, Wang, Z, Greer, PK, Zhu, H, Wang, CY, Carpenter, AB, Friedman, H, Friedman, AH, Keir, ST, He, J, He, Y, McLendon, RE, Herndon, JE, Yan, H, and Bigner, DD. "Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas." Oncotarget 5, no. 6 (March 2014): 1515-1525.
  - Wortham, M, Guo, C, Zhang, M, Song, L, Lee, B-K, Iyer, VR, Furey, TS, Crawford, GE, Yan, H, and He, Y. "Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma." PloS one 9, no. 9 (January 2014): e107156-. Full Text Open Access Copy
  - Reitman, ZJ, Pirozzi, CJ, and Yan, H. "Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors." Acta Neuropathol 126, no. 6 (December 2013): 789-792. Full Text Link to Item
  - Reitman, ZJ, Pirozzi, CJ, and Yan, H. "Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors." Acta Neuropathologica 126, no. 6 (November 12, 2013): 789-792. (Review) Full Text
  - Guo, C, Chen, LH, Huang, Y, Chang, C-C, Wang, P, Pirozzi, CJ, Qin, X, Bao, X, Greer, PK, McLendon, RE, Yan, H, Keir, ST, Bigner, DD, and He, Y. "KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation." Oncotarget 4, no. 11 (November 2013): 2144-2153. Full Text Link to Item
  - Frattini, V, Trifonov, V, Chan, JM, Castano, A, Lia, M, Abate, F, Keir, ST, Ji, AX, Zoppoli, P, Niola, F, Danussi, C, Dolgalev, I, Porrati, P, Pellegatta, S, Heguy, A, Gupta, G, Pisapia, DJ, Canoll, P, Bruce, JN, McLendon, RE, Yan, H, Aldape, K, Finocchiaro, G, Mikkelsen, T, Privé, GG, Bigner, DD, Lasorella, A, Rabadan, R, and Iavarone, A. "The integrated landscape of driver genomic alterations in glioblastoma." Nat Genet 45, no. 10 (October 2013): 1141-1149. Full Text Link to Item
  - Hodges, TR, Choi, BD, Bigner, DD, Yan, H, and Sampson, JH. "Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review." J Neurosurg 118, no. 6 (June 2013): 1176-1180. (Review) Full Text Link to Item
  - Pirozzi, CJ, Reitman, ZJ, and Yan, H. "Releasing the block: setting differentiation free with mutant IDH inhibitors." Cancer Cell 23, no. 5 (May 13, 2013): 570-572. Full Text Link to Item
  - Killela, PJ, Reitman, ZJ, Jiao, Y, Bettegowda, C, Agrawal, N, Diaz, LA, Friedman, AH, Friedman, H, Gallia, GL, Giovanella, BC, Grollman, AP, He, T-C, He, Y, Hruban, RH, Jallo, GI, Mandahl, N, Meeker, AK, Mertens, F, Netto, GJ, Rasheed, BA, Riggins, GJ, Rosenquist, TA, Schiffman, M, Shih, I-M, Theodorescu, D, Torbenson, MS, Velculescu, VE, Wang, T-L, Wentzensen, N, Wood, LD, Zhang, M, McLendon, RE, Bigner, DD, Kinzler, KW, Vogelstein, B, Papadopoulos, N, and Yan, H. "TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal." Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 6021-6026. Full Text Link to Item
  - Bettegowda, C, Agrawal, N, Jiao, Y, Wang, Y, Wood, LD, Rodriguez, FJ, Hruban, RH, Gallia, GL, Binder, ZA, Riggins, CJ, Salmasi, V, Riggins, GJ, Reitman, ZJ, Rasheed, A, Keir, S, Shinjo, S, Marie, S, McLendon, R, Jallo, G, Vogelstein, B, Bigner, D, Yan, H, Kinzler, KW, and Papadopoulos, N. "Exomic Sequencing of Four Rare Central Nervous System Tumor Types." ONCOTARGET 4, no. 4 (April 2013): 572-583. Link to Item
  - Poteet, E, Choudhury, GR, Winters, A, Li, W, Ryou, M-G, Liu, R, Tang, L, Ghorpade, A, Wen, Y, Yuan, F, Keir, ST, Yan, H, Bigner, DD, Simpkins, JW, and Yang, S-H. "Reversing the Warburg effect as a treatment for glioblastoma." J Biol Chem 288, no. 13 (March 29, 2013): 9153-9164. Full Text Link to Item
  - Jin, G, Reitman, ZJ, Duncan, CG, Spasojevic, I, Gooden, DM, Rasheed, BA, Yang, R, Lopez, GY, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas." Cancer Res 73, no. 2 (January 15, 2013): 496-501. Full Text Link to Item
  - Frattini, V, Trifonov, V, Chan, JM, Castano, A, Lia, M, Abate, F, Keir, ST, Ji, AX, Zoppoli, P, Niola, F, and al, E. "The integrated landscape of driver genomic alterations in glioblastoma." Nature Genetics 45, no. 10 (2013): 1141-1149. Full Text
  - Duncan, CG, Barwick, BG, Jin, G, Rago, C, Kapoor-Vazirani, P, Powell, DR, Chi, J-T, Bigner, DD, Vertino, PM, and Yan, H. "A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation." Genome Res 22, no. 12 (December 2012): 2339-2355. Full Text Link to Item
  - Reitman, ZJ, Choi, BD, Spasojevic, I, Bigner, DD, Sampson, JH, and Yan, H. "Enzyme redesign guided by cancer-derived IDH1 mutations." Nat Chem Biol 8, no. 11 (November 2012): 887-889. Full Text Link to Item
  - Guo, C, Chang, C-C, Wortham, M, Chen, LH, Kernagis, DN, Qin, X, Cho, Y-W, Chi, J-T, Grant, GA, McLendon, RE, Yan, H, Ge, K, Papadopoulos, N, Bigner, DD, and He, Y. "Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways." Proc Natl Acad Sci U S A 109, no. 43 (October 23, 2012): 17603-17608. Full Text Link to Item
  - Jin, G, Pirozzi, CJ, Chen, LH, Lopez, GY, Duncan, CG, Feng, J, Spasojevic, I, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 is required for IDH1 mutated tumor cell growth." Oncotarget 3, no. 8 (August 2012): 774-782. Full Text Link to Item
  - Jiao, Y, Killela, PJ, Reitman, ZJ, Rasheed, AB, Heaphy, CM, de Wilde, RF, Rodriguez, FJ, Rosemberg, S, Oba-Shinjo, SM, Nagahashi Marie, SK, Bettegowda, C, Agrawal, N, Lipp, E, Pirozzi, C, Lopez, G, He, Y, Friedman, H, Friedman, AH, Riggins, GJ, Holdhoff, M, Burger, P, McLendon, R, Bigner, DD, Vogelstein, B, Meeker, AK, Kinzler, KW, Papadopoulos, N, Diaz, LA, and Yan, H. "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas." Oncotarget 3, no. 7 (July 2012): 709-722. Full Text Link to Item
  - Wortham, M, and Yan, H. "Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells." Cancer Discov 2, no. 6 (June 2012): 492-494. Full Text Link to Item
  - Koivunen, P, Lee, S, Duncan, CG, Lopez, G, Lu, G, Ramkissoon, S, Losman, JA, Joensuu, P, Bergmann, U, Gross, S, Travins, J, Weiss, S, Looper, R, Ligon, KL, Verhaak, RGW, Yan, H, and Kaelin, WG. "Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. (Published online)" Nature 483, no. 7390 (February 15, 2012): 484-488. Full Text Link to Item
  - Jones, S, Li, M, Parsons, DW, Zhang, X, Wesseling, J, Kristel, P, Schmidt, MK, Markowitz, S, Yan, H, Bigner, D, Hruban, RH, Eshleman, JR, Iacobuzio-Donahue, CA, Goggins, M, Maitra, A, Malek, SN, Powell, S, Vogelstein, B, Kinzler, KW, Velculescu, VE, and Papadopoulos, N. "Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types." Hum Mutat 33, no. 1 (January 2012): 100-103. Full Text Link to Item
  - Li, M, Lockwood, W, Zielenska, M, Northcott, P, Ra, YS, Bouffet, E, Yoshimoto, M, Rutka, JT, Yan, H, Taylor, MD, Eberhart, C, Hawkins, CE, Lam, W, Squire, JA, and Huang, A. "Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor." Cancer Genetics 205, no. 5 (2012): 220-231. Full Text
  - Wortham, M, Jin, G, Sun, JL, Bigner, DD, He, Y, and Yan, H. "Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells." PLoS One 7, no. 4 (2012): e36211-. Full Text Link to Item
  - Guo, C, Pirozzi, CJ, Lopez, GY, and Yan, H. "Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target." Curr Opin Neurol 24, no. 6 (December 2011): 648-652. (Review) Full Text Link to Item
  - Bettegowda, C, Agrawal, N, Jiao, Y, Sausen, M, Wood, LD, Hruban, RH, Rodriguez, FJ, Cahill, DP, McLendon, R, Riggins, G, Velculescu, VE, Oba-Shinjo, SM, Marie, SKN, Vogelstein, B, Bigner, D, Yan, H, Papadopoulos, N, and Kinzler, KW. "Mutations in CIC and FUBP1 contribute to human oligodendroglioma." Science 333, no. 6048 (September 9, 2011): 1453-1455. Full Text Link to Item
  - Heaphy, CM, de Wilde, RF, Jiao, Y, Klein, AP, Edil, BH, Shi, C, Bettegowda, C, Rodriguez, FJ, Eberhart, CG, Hebbar, S, Offerhaus, GJ, McLendon, R, Rasheed, BA, He, Y, Yan, H, Bigner, DD, Oba-Shinjo, SM, Marie, SKN, Riggins, GJ, Kinzler, KW, Vogelstein, B, Hruban, RH, Maitra, A, Papadopoulos, N, and Meeker, AK. "Altered telomeres in tumors with ATRX and DAXX mutations." Science 333, no. 6041 (July 22, 2011): 425-. Full Text Link to Item
  - Duncan, CG, and Yan, H. "Genomic alterations and the pathogenesis of glioblastoma." Cell Cycle 10, no. 8 (April 15, 2011): 1174-1175. Full Text Link to Item
  - Reitman, ZJ, Jin, G, Karoly, ED, Spasojevic, I, Yang, J, Kinzler, KW, He, Y, Bigner, DD, Vogelstein, B, and Yan, H. "Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome." Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3270-3275. Full Text Link to Item
  - Jin, G, Reitman, ZJ, Spasojevic, I, Batinic-Haberle, I, Yang, J, Schmidt-Kittler, O, Bigner, DD, and Yan, H. "2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. (Published online)" PLoS One 6, no. 2 (February 4, 2011): e16812-. Full Text Link to Item
  - Parsons, DW, Li, M, Zhang, X, Jones, S, Leary, RJ, Lin, JC-H, Boca, SM, Carter, H, Samayoa, J, Bettegowda, C, Gallia, GL, Jallo, GI, Binder, ZA, Nikolsky, Y, Hartigan, J, Smith, DR, Gerhard, DS, Fults, DW, VandenBerg, S, Berger, MS, Marie, SKN, Shinjo, SMO, Clara, C, Phillips, PC, Minturn, JE, Biegel, JA, Judkins, AR, Resnick, AC, Storm, PB, Curran, T, He, Y, Rasheed, BA, Friedman, HS, Keir, ST, McLendon, R, Northcott, PA, Taylor, MD, Burger, PC, Riggins, GJ, Karchin, R, and Parmigiani, G et al. "The genetic landscape of the childhood cancer medulloblastoma." Science 331, no. 6016 (January 28, 2011): 435-439. Full Text Link to Item
  - Jin, G, Cook, S, Cui, B, Chen, WC, Keir, ST, Killela, P, Di, C, Payne, CA, Gregory, SG, McLendon, R, Bigner, DD, and Yan, H. "HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea." Neuro Oncol 12, no. 9 (September 2010): 956-966. Full Text Link to Item
  - Duncan, CG, Killela, PJ, Payne, CA, Lampson, B, Chen, WC, Liu, J, Solomon, D, Waldman, T, Towers, AJ, Gregory, SG, McDonald, KL, McLendon, RE, Bigner, DD, and Yan, H. "Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes." Oncotarget 1, no. 4 (August 2010): 265-277. Full Text Link to Item
  - Lopez, GY, Reitman, ZJ, Solomon, D, Waldman, T, Bigner, DD, McLendon, RE, Rosenberg, SA, Samuels, Y, and Yan, H. "IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain." Biochem Biophys Res Commun 398, no. 3 (July 30, 2010): 585-587. Full Text Link to Item
  - Reitman, ZJ, and Yan, H. "Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism." J Natl Cancer Inst 102, no. 13 (July 7, 2010): 932-941. (Review) Full Text Link to Item
  - Reitman, ZJ, Olby, NJ, Mariani, CL, Thomas, R, Breen, M, Bigner, DD, McLendon, RE, and Yan, H. "IDH1 and IDH2 hotspot mutations are not found in canine glioma." Int J Cancer 127, no. 1 (July 1, 2010): 245-246. (Letter) Full Text Link to Item
  - Reitman, ZJ, Parsons, DW, and Yan, H. "IDH1 and IDH2: not your typical oncogenes." Cancer Cell 17, no. 3 (March 16, 2010): 215-216. Full Text Link to Item
  - Adamson, DC, Shi, Q, Wortham, M, Northcott, PA, Di, C, Duncan, CG, Li, J, McLendon, RE, Bigner, DD, Taylor, MD, and Yan, H. "OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas." Cancer Res 70, no. 1 (January 1, 2010): 181-191. Full Text Link to Item
  - Nakahara, Y, Northcott, PA, Li, M, Kongkham, PN, Smith, C, Yan, H, Croul, S, Ra, Y-S, Eberhart, C, Huang, A, Bigner, D, Grajkowska, W, Van Meter, T, Rutka, JT, and Taylor, MD. "Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma." Neoplasia 12, no. 1 (January 2010): 20-27. Link to Item
  - Kato, Y, Jin, G, Kuan, C-T, McLendon, RE, Yan, H, and Bigner, DD. "A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation." Biochem Biophys Res Commun 390, no. 3 (December 18, 2009): 547-551. Full Text Link to Item
  - Yan, H, Bigner, DD, Velculescu, V, and Parsons, DW. "Mutant metabolic enzymes are at the origin of gliomas." Cancer Res 69, no. 24 (December 15, 2009): 9157-9159. (Review) Full Text Link to Item
  - Lu, Z, Zhou, L, Killela, P, Rasheed, AB, Di, C, Poe, WE, McLendon, RE, Bigner, DD, Nicchitta, C, and Yan, H. "Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress." Cancer Res 69, no. 23 (December 1, 2009): 9105-9111. Full Text Link to Item
  - Solomon, DA, Kim, J-S, Ressom, HW, Sibenaller, Z, Ryken, T, Jean, W, Bigner, D, Yan, H, and Waldman, T. "Sample type bias in the analysis of cancer genomes." Cancer Res 69, no. 14 (July 15, 2009): 5630-5633. Full Text Link to Item
  - Kanu, OO, Mehta, A, Di, C, Lin, N, Bortoff, K, Bigner, DD, Yan, H, and Adamson, DC. "Glioblastoma multiforme: a review of therapeutic targets." Expert Opin Ther Targets 13, no. 6 (June 2009): 701-718. (Review) Full Text Link to Item
  - Duncan, CG, Leary, RJ, Lin, JC-H, Cummins, J, Di, C, Schaefer, CF, Wang, T-L, Riggins, GJ, Edwards, J, Bigner, D, Kopelovich, L, Vogelstein, B, Kinzler, KW, Velculescu, VE, and Yan, H. "Identification of microbial DNA in human cancer. (Published online)" BMC Med Genomics 2 (May 8, 2009): 22-. Full Text Link to Item
  - Kanu, OO, Hughes, B, Di, C, Lin, N, Fu, J, Bigner, DD, Yan, H, and Adamson, C. "Glioblastoma Multiforme Oncogenomics and Signaling Pathways." Clin Med Oncol 3 (April 8, 2009): 39-52. Link to Item
  - Yan, H, Parsons, DW, Jin, G, McLendon, R, Rasheed, BA, Yuan, W, Kos, I, Batinic-Haberle, I, Jones, S, Riggins, GJ, Friedman, H, Friedman, A, Reardon, D, Herndon, J, Kinzler, KW, Velculescu, VE, Vogelstein, B, and Bigner, DD. "IDH1 and IDH2 mutations in gliomas." N Engl J Med 360, no. 8 (February 19, 2009): 765-773. Full Text Link to Item
  - Reitman, Z, and Yan, H. "The author and a colleague reply." New England Journal of Medicine 360, no. 21 (2009): 2249--. Full Text
  - Solomon, DA, Kim, J-S, Cronin, JC, Sibenaller, Z, Ryken, T, Rosenberg, SA, Ressom, H, Jean, W, Bigner, D, Yan, H, Samuels, Y, and Waldman, T. "Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma." Cancer Res 68, no. 24 (December 15, 2008): 10300-10306. Full Text Link to Item
  - Parsons, DW, Jones, S, Zhang, X, Lin, JC-H, Leary, RJ, Angenendt, P, Mankoo, P, Carter, H, Siu, I-M, Gallia, GL, Olivi, A, McLendon, R, Rasheed, BA, Keir, S, Nikolskaya, T, Nikolsky, Y, Busam, DA, Tekleab, H, Diaz, LA, Hartigan, J, Smith, DR, Strausberg, RL, Marie, SKN, Shinjo, SMO, Yan, H, Riggins, GJ, Bigner, DD, Karchin, R, Papadopoulos, N, Parmigiani, G, Vogelstein, B, Velculescu, VE, and Kinzler, KW. "An integrated genomic analysis of human glioblastoma multiforme." Science 321, no. 5897 (September 26, 2008): 1807-1812. Full Text Link to Item
  - Solomon, DA, Kim, J-S, Jenkins, S, Ressom, H, Huang, M, Coppa, N, Mabanta, L, Bigner, D, Yan, H, Jean, W, and Waldman, T. "Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme." Cancer Res 68, no. 8 (April 15, 2008): 2564-2569. Full Text Link to Item
  - Wood, LD, Calhoun, ES, Silliman, N, Ptak, J, Szabo, S, Powell, SM, Riggins, GJ, Wang, T-L, Yan, H, Gazdar, A, Kern, SE, Pennacchio, L, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers." Hum Mutat 27, no. 10 (October 2006): 1060-1061. Full Text Link to Item
  - Parrett, TJ, and Yan, H. "Digital karyotyping technology: exploring the cancer genome." Expert Rev Mol Diagn 5, no. 6 (November 2005): 917-925. (Review) Full Text Link to Item
  - Di, C, Liao, S, Adamson, DC, Parrett, TJ, Broderick, DK, Shi, Q, Lengauer, C, Cummins, JM, Velculescu, VE, Fults, DW, McLendon, RE, Bigner, DD, and Yan, H. "Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid." Cancer Res 65, no. 3 (February 1, 2005): 919-924. Link to Item
  - Yan, H. "Snapshot of the allele-specific variation in human gene expression." Methods Mol Biol 311 (2005): 31-38. Full Text Link to Item
  - Rich, JN, Rasheed, BKA, and Yan, H. "EGFR mutations and sensitivity to gefitinib." N Engl J Med 351, no. 12 (September 16, 2004): 1260-1261. (Letter) Link to Item
  - Broderick, DK, Di, C, Parrett, TJ, Samuels, YR, Cummins, JM, McLendon, RE, Fults, DW, Velculescu, VE, Bigner, DD, and Yan, H. "Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas." Cancer Res 64, no. 15 (August 1, 2004): 5048-5050. Full Text Link to Item
  - Wang, Z, Shen, D, Parsons, DW, Bardelli, A, Sager, J, Szabo, S, Ptak, J, Silliman, N, Peters, BA, van der Heijden, MS, Parmigiani, G, Yan, H, Wang, T-L, Riggins, G, Powell, SM, Willson, JKV, Markowitz, S, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "Mutational analysis of the tyrosine phosphatome in colorectal cancers." Science 304, no. 5674 (May 21, 2004): 1164-1166. Full Text Link to Item
  - Samuels, Y, Wang, Z, Bardelli, A, Silliman, N, Ptak, J, Szabo, S, Yan, H, Gazdar, A, Powell, SM, Riggins, GJ, Willson, JKV, Markowitz, S, Kinzler, KW, Vogelstein, B, and Velculescu, VE. "High frequency of mutations of the PIK3CA gene in human cancers." Science 304, no. 5670 (April 23, 2004): 554-. Full Text Link to Item
  - Butz, JA, Yan, H, Mikkilineni, V, and Edwards, JS. "Detection of allelic variations of human gene expression by polymerase colonies. (Published online)" BMC Genet 5 (February 16, 2004): 3-. Full Text Link to Item
  - Sorscher, SM, Rich, JN, Rasheed, BKA, Yan, H, Rossi, G, Marchioni, A, Longo, L, Haber, DA, Bell, DW, and Lynch, TJ. "EGFR mutations and sensitivity to gefitinib [3] (multiple letters)." New England Journal of Medicine 351, no. 12 (2004): 1260-1261. Full Text
  - Yan, H, and Zhou, W. "Allelic variations in gene expression." Curr Opin Oncol 16, no. 1 (January 2004): 39-43. (Review) Link to Item
  - Dressman, D, Yan, H, Traverso, G, Kinzler, KW, and Vogelstein, B. "Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations." Proc Natl Acad Sci U S A 100, no. 15 (July 22, 2003): 8817-8822. Full Text Link to Item
  - Yan, H, Yuan, W, Velculescu, VE, Vogelstein, B, and Kinzler, KW. "Allelic variation in human gene expression." Science 297, no. 5584 (August 16, 2002): 1143-. Full Text Link to Item
  - Nakagawa, H, Yan, H, Lockman, J, Hampel, H, Kinzler, KW, Vogelstein, B, and De La Chapelle, A. "Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements." Cancer Res 62, no. 16 (August 15, 2002): 4579-4582. Link to Item
  - Nguyen, V-P, Saleh, AZM, Arch, AE, Yan, H, Piazza, F, Kim, J, and Krolewski, JJ. "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling." J Biol Chem 277, no. 12 (March 22, 2002): 9713-9721. Full Text Link to Item
  - Yan, H, Dobbie, Z, Gruber, SB, Markowitz, S, Romans, K, Giardiello, FM, Kinzler, KW, and Vogelstein, B. "Small changes in expression affect predisposition to tumorigenesis." Nat Genet 30, no. 1 (January 2002): 25-26. Full Text Link to Item
  - Liu, T, Yan, H, Kuismanen, S, Percesepe, A, Bisgaard, ML, Pedroni, M, Benatti, P, Kinzler, KW, Vogelstein, B, Ponz de Leon, M, Peltomäki, P, and Lindblom, A. "The role of hPMS1 and hPMS2 in predisposing to colorectal cancer." Cancer Res 61, no. 21 (November 1, 2001): 7798-7802. Link to Item
  - Marra, G, D'Atri, S, Yan, H, Perrera, C, Cannavo', E, Vogelstein, B, and Jiricny, J. "Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes." Cancer Res 61, no. 21 (November 1, 2001): 7719-7721. Link to Item
  - Langer, S, Jentsch, I, Gangnus, R, Yan, H, Lengauer, C, and Speicher, MR. "Facilitating haplotype analysis by fully automated analysis of all chromosomes in human-mouse hybrid cell lines." Cytogenet Cell Genet 93, no. 1-2 (2001): 11-15. Link to Item
  - Yan, H, Kinzler, KW, and Vogelstein, B. "Tech.sight. Genetic testing--present and future." Science 289, no. 5486 (September 15, 2000): 1890-1892. (Review) Link to Item
  - Yan, H, Papadopoulos, N, Marra, G, Perrera, C, Jiricny, J, Boland, CR, Lynch, HT, Chadwick, RB, de la Chapelle, A, Berg, K, Eshleman, JR, Yuan, W, Markowitz, S, Laken, SJ, Lengauer, C, Kinzler, KW, and Vogelstein, B. "Conversion of diploidy to haploidy." Nature 403, no. 6771 (February 17, 2000): 723-724. Full Text Link to Item
  - Yan, H, Kinzler, KW, and Vogelstein, B. "Genetic testing - Present and future." Science 289, no. 5486 (2000): 1890-1892. Full Text
  - Yan, H, Piazza, F, Krishnan, K, Pine, R, and Krolewski, JJ. "Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase." J Biol Chem 273, no. 7 (February 13, 1998): 4046-4051. Link to Item
  - Yan, H, Piazza, F, Krishnan, K, Pine, R, and Krolewski, JJ. "Definition of the interferon-α receptor-binding domain on the TYK2 kinase." Journal of Biological Chemistry 273, no. 7 (1998): 4045-4051.
  - Domanski, P, Fish, E, Nadeau, OW, Witte, M, Platanias, LC, Yan, H, Krolewski, J, Pitha, P, and Colamonici, OR. "A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state." J Biol Chem 272, no. 42 (October 17, 1997): 26388-26393. Link to Item
  - Krishnan, K, Yan, H, Lim, JT, and Krolewski, JJ. "Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation." Oncogene 13, no. 1 (July 4, 1996): 125-133. Link to Item
  - Yan, H, Krishnan, K, Lim, JT, Contillo, LG, and Krolewski, JJ. "Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction." Mol Cell Biol 16, no. 5 (May 1996): 2074-2082. Link to Item
  - Davis, E, Krishnan, K, Yan, H, Newcomb, EW, and Krolewski, JJ. "A mutant form of p135tyk2, an interferon-alpha inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells." Leukemia 10, no. 3 (March 1996): 543-551. Link to Item
  - Gupta, S, Yan, H, Wong, LH, Ralph, S, Krolewski, J, and Schindler, C. "The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals." EMBO J 15, no. 5 (March 1, 1996): 1075-1084. Link to Item
  - Yan, H, Krishnan, K, Greenlund, AC, Gupta, S, Lim, JT, Schreiber, RD, Schindler, CW, and Krolewski, JJ. "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein." EMBO J 15, no. 5 (March 1, 1996): 1064-1074. Link to Item
  - Yan, H, Krishnan, K, Lim, JTE, and Krolewski, J. "Interferon a receptor 1 subunit (IFNaRI) binds to TYK2 and acts as a docking site for STAT2." FASEB Journal 10, no. 6 (1996): A1516-.
  - Domanski, P, Yan, H, Witte, MM, Krolewski, J, and Colamonici, OR. "Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase." FEBS Lett 374, no. 3 (November 6, 1995): 317-322. Link to Item
  - Yan, H, Lim, JT, Contillo, LG, and Krolewski, JJ. "Glutathione S-transferase fusion proteins mimic receptor dimerization in permeabilized cells." Anal Biochem 231, no. 2 (November 1, 1995): 455-458. Full Text Link to Item
  - Greenlund, AC, Morales, MO, Viviano, BL, Yan, H, Krolewski, J, and Schreiber, RD. "Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process." Immunity 2, no. 6 (June 1995): 677-687. Link to Item
  - Colamonici, O, Yan, H, Domanski, P, Handa, R, Smalley, D, Mullersman, J, Witte, M, Krishnan, K, and Krolewski, J. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase." Mol Cell Biol 14, no. 12 (December 1994): 8133-8142. Link to Item
  - Colamonici, OR, Uyttendaele, H, Domanski, P, Yan, H, and Krolewski, JJ. "p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor." J Biol Chem 269, no. 5 (February 4, 1994): 3518-3522. Link to Item
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