Overview
Dr. Hanzhang Xu, PhD, RN, FAAN, is an Associate Professor at the Duke University School of Nursing with joint appointments at the Duke University School of Medicine in the Department of Family Medicine and Community Health and the Duke-NUS Medical School in the Health Services & Systems Research Signature Program. She also serves as a Senior Fellow at Duke's Center for the Study of Aging and Human Development and as a Faculty Affiliate at the Duke Global Health Institute.
As a clinician scientist, Dr. Xu’s research and scholarship center around social determinants of health and disparities in health care and outcomes in diverse older adult populations, with a particular focus on cardiovascular and brain health. Her current program of research falls under two themes: (i) health disparities in a multinational context, with a particular focus on the cognitive function and dementia care among older adults; and (ii) the integration of patient-reported social factors in cardiovascular outcome research.
She has led several research projects funded by the National Institutes of Health (NIH) that leverage the strengths of big data repositories such as electronic health records (EHR), Medicare claims, national survey data and disease registries to improve the cardiovascular and brain health of older adults, with a total award amount being over $5 million. Her work in these areas has been widely cited by researchers in at least 53 countries across 6 continents, and has been featured in international media outlets, including in Yahoo!, TIME, Forbes, and the Mirror.
Dr. Xu is a Fellow of the American Academy of Nursing and was inducted into Sigma Theta Tau International Honor Society of Nursing. She serves on the Editorial Board of the Journal of Aging and Health.
Xu earned her PhD from Duke University.
Current Appointments & Affiliations
Recent Publications
Positive Coping, Psychological Distress, and Medication Adherence Among People Living with HIV/AIDS in Henan, China: A Moderated Mediation Analysis.
Journal Article AIDS and behavior · October 2025 Full text CiteDigital Divide or Educational Divide? The Impact of Social Media on COVID-19 Vaccination in Middle-Aged and Older Adults.
Journal Article medRxiv · September 7, 2025 The spread of disinformation and harmful content on social media is well-known. However, most research focuses on the negative influence of social media on the well-being of adolescents and teenagers. We used data from the 2022 Health and Retirement Study ... Full text Link to item CiteRacial and ethnic disparities in longitudinal trajectories of hospitalizations in patients diagnosed with heart failure.
Journal Article Am Heart J · September 2025 BACKGROUND: Racial and ethnic disparities in hospitalizations among heart failure (HF) patients have been well documented. However, little is known about racial and ethnic differences in the long-term trajectories of hospital admissions that follow the dia ... Full text Link to item CiteRecent Grants
Characterizing Family Structure, Care Utilization, and Well-Being among Persons with ADRD in the Asian Region
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030Poststroke Cognitive Impairment and Dementia
ResearchPrincipal Investigator · Awarded by University of Texas - Southwestern · 2024 - 2029Duke/UNC ADAR Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029View All Grants