Scholars@Duke

• Research
• 

  Selected Grants

  • Balancing Risks and Benefits of Direct Oral Anticoagulants in Older Ischemic Stroke Patients with Atrial Fibrillation awarded by National Institutes of Health 2020 - 2025
  • The Impact of Quality Metrics on Outcomes among Elderly Heart Failure Patients awarded by Dartmouth College 2019 - 2021
  • National Surveillance of Stroke Outcomes and Quality of Care using the Get With the Guidelines(GWTG) Stroke Registry awarded by University of California - Los Angeles 2017 - 2021
  • Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research awarded by Patient Centered Outcomes Research Institute 2013 - 2020
  • Mapping Quality in the Stroke System of Care: Do hospitals that share in the care of Acute Stroke patients also share awarded by Massachusetts General Hospital 2016 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zachrison, K. S., Schwamm, L. H., Xu, H., Matsouaka, R., Shah, S., Smith, E. E., … Saver, J. (2021). Frequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice. Stroke, STROKEAHA121034069. https://doi.org/10.1161/STROKEAHA.121.034069
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    • Bahiru, E., Ziaeian, B., Moucheraud, C., Agarwal, A., Xu, H., Matsouaka, R. A., … Fonarow, G. C. (2021). Association of Dual Eligibility for Medicare and Medicaid With Heart Failure Quality and Outcomes Among Get With The Guidelines-Heart Failure Hospitals. Jama Cardiol, 6(7), 791–800. https://doi.org/10.1001/jamacardio.2021.0611
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    • Forrest, C. B., Xu, H., Thomas, L. E., Webb, L. E., Cohen, L. W., Carey, T. S., … HERO Registry Research Group, . (2021). Impact of the Early Phase of the COVID-19 Pandemic on US Healthcare Workers: Results from the HERO Registry. J Gen Intern Med, 36(5), 1319–1326. https://doi.org/10.1007/s11606-020-06529-z
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    • Ziaeian, B., Xu, H., Matsouaka, R. A., Xian, Y., Khan, Y., Schwamm, L. S., … Fonarow, G. C. (2021). National surveillance of stroke quality of care and outcomes by applying post-stratification survey weights on the Get With The Guidelines-Stroke patient registry. Bmc Med Res Methodol, 21(1), 23. https://doi.org/10.1186/s12874-021-01214-z
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    • Etherton, M. R., Shah, S., Haolin, X., Xian, Y., Maisch, L., Hannah, D., … O’Brien, E. C. (2021). Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors. Stroke Vasc Neurol. https://doi.org/10.1136/svn-2020-000691
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    • Akbik, F., Xu, H., Xian, Y., Shah, S., Smith, E. E., Bhatt, D. L., … Schwamm, L. H. (2020). Trends in Reperfusion Therapy for In-Hospital Ischemic Stroke in the Endovascular Therapy Era. Jama Neurol, 77(12), 1486–1495. https://doi.org/10.1001/jamaneurol.2020.3362
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    • Dalgaard, F., Xu, H., Matsouaka, R. A., Russo, A. M., Curtis, A. B., Rasmussen, P. V., … Al-Khatib, S. M. (2020). Management of Atrial Fibrillation in Older Patients by Morbidity Burden: Insights From Get With The Guidelines-Atrial Fibrillation. J Am Heart Assoc, 9(23), e017024. https://doi.org/10.1161/JAHA.120.017024
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    • Figueroa, J. F., Wadhera, R. K., Frakt, A. B., Fonarow, G. C., Heidenreich, P. A., Xu, H., … Joynt Maddox, K. E. (2020). Quality of Care and Outcomes Among Medicare Advantage vs Fee-for-Service Medicare Patients Hospitalized With Heart Failure. Jama Cardiol, 5(12), 1349–1357. https://doi.org/10.1001/jamacardio.2020.3638
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    • Mentz, R. J., Xu, H., O’Brien, E. C., Thomas, L., Alexy, T., Gupta, B., … Hernandez, A. F. (2020). PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure. Am Heart J, 230, 35–43. https://doi.org/10.1016/j.ahj.2020.09.012
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    • Sterling, M. R., Kern, L. M., Safford, M. M., Jones, C. D., Feldman, P. H., Fonarow, G. C., … Albert, N. M. (2020). Home Health Care Use and Post-Discharge Outcomes After Heart Failure Hospitalizations. Jacc Heart Fail, 8(12), 1038–1049. https://doi.org/10.1016/j.jchf.2020.06.009
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    • Luo, N., Hammill, B. G., DeVore, A. D., Xu, H., Fonarow, G. C., Albert, N. M., … Mentz, R. J. (2020). Outcomes and cost among Medicare beneficiaries hospitalized for heart failure assigned to accountable care organizations. Am Heart J, 226, 13–23. https://doi.org/10.1016/j.ahj.2020.04.028
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    • Sharma, A., Wu, J., Xu, H., Hernandez, A., Felker, G. M., Al-Khatib, S., … DeVore, A. (2020). Comparative Effectiveness of Primary Prevention Implantable Cardioverter-Defibrillators in Older Heart Failure Patients With Diabetes Mellitus. J Am Heart Assoc, 9(12), e012405. https://doi.org/10.1161/JAHA.119.012405
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    • Fudim, M., Sayeed, S., Xu, H., Matsouaka, R. A., Heidenreich, P. A., Velazquez, E. J., … DeVore, A. D. (2020). Representativeness of the PIONEER-HF Clinical Trial Population in Patients Hospitalized With Heart Failure and Reduced Ejection Fraction. Circ Heart Fail, 13(4), e006645. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006645
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    • O’Connor, K. D., Brophy, T., Fonarow, G. C., Blankstein, R., Swaminathan, R. V., Xu, H., … DeVore, A. D. (2020). Testing for Coronary Artery Disease in Older Patients With New-Onset Heart Failure: Findings From Get With The Guidelines-Heart Failure. Circ Heart Fail, 13(4), e006963. https://doi.org/10.1161/CIRCHEARTFAILURE.120.006963
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    • Naidech, A. M., Lawlor, P. N., Xu, H., Fonarow, G. C., Xian, Y., Smith, E. E., … Kording, K. P. (2020). Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs. Front Neurol, 11, 961. https://doi.org/10.3389/fneur.2020.00961
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    • Sayeed, S., Fudim, M., Devore, A. D., Xu, H., Matsouaka, R. A., Heidenreich, P. A., … Hernandez, A. F. (2019). PARAGON-HF Clinical Trial Eligibility in a Population of Patients Hospitalized With Heart Failure. J Card Fail, 25(12), 1009–1011. https://doi.org/10.1016/j.cardfail.2019.10.003
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    • Xian, Y., Xu, H., O’Brien, E. C., Shah, S., Thomas, L., Pencina, M. J., … Hernandez, A. F. (2019). Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study. Jama Neurol, 76(10), 1192–1202. https://doi.org/10.1001/jamaneurol.2019.2099
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    • Prabhakaran, S., Messé, S. R., Kleindorfer, D., Smith, E. E., Fonarow, G. C., Xu, H., … Schwamm, L. H. (2019). Cryptogenic stroke: Contemporary trends, treatments, and outcomes in the United States. Neurology: Clinical Practice, 00(00), 1–10. https://doi.org/10.1212/cpj.0000000000000736
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    • Ali-Ahmed, F., Federspiel, J. J., Liang, L., Xu, H., Sevilis, T., Hernandez, A. F., … Xian, Y. (2019). Intravenous Tissue Plasminogen Activator in Stroke Mimics. Circ Cardiovasc Qual Outcomes, 12(8), e005609. https://doi.org/10.1161/CIRCOUTCOMES.119.005609
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    • Ehrlich, M. E., Liang, L., Xu, H., Kosinski, A. S., Hernandez, A. F., Schwamm, L. H., … Xian, Y. (2019). Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus. Stroke, 50(6), 1497–1503. https://doi.org/10.1161/STROKEAHA.118.024172
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    • Dandapat, S., Siddiqui, F. M., Fonarow, G. C., Bhatt, D. L., Xu, H., Matsouaka, R., … Smith, E. E. (2019). A paradoxical relationship between hemoglobin A1C and in-hospital mortality in intracerebral hemorrhage patients. Heliyon, 5(5), e01659. https://doi.org/10.1016/j.heliyon.2019.e01659
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    • Ziaeian, B., Hernandez, A. F., DeVore, A. D., Wu, J., Xu, H., Heidenreich, P. A., … Fonarow, G. C. (2019). Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry. Am Heart J, 211, 1–10. https://doi.org/10.1016/j.ahj.2019.01.006
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    • Piccini, J. P., Xu, H., Cox, M., Matsouaka, R. A., Fonarow, G. C., Butler, J., … Get With The Guidelines-AFIB Clinical Working Group and Hospitals, . (2019). Adherence to Guideline-Directed Stroke Prevention Therapy for Atrial Fibrillation Is Achievable. Circulation, 139(12), 1497–1506. https://doi.org/10.1161/CIRCULATIONAHA.118.035909
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    • Menon, B. K., Xu, H., Cox, M., Saver, J. L., Goyal, M., Peterson, E., … Smith, E. E. (2019). Components and Trends in Door to Treatment Times for Endovascular Therapy in Get With The Guidelines-Stroke Hospitals. Circulation, 139(2), 169–179. https://doi.org/10.1161/CIRCULATIONAHA.118.036701
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    • Luo, N., Xu, H., Jneid, H., Fonarow, G. C., Lopes, R. D., Piccini, J. P., … Al-Khatib, S. M. (2018). Use of Oral Anticoagulation in Eligible Patients Discharged With Heart Failure and Atrial Fibrillation. Circ Heart Fail, 11(10), e005356. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005356
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    • Warraich, H. J., Xu, H., DeVore, A. D., Matsouaka, R., Heidenreich, P. A., Bhatt, D. L., … Allen, L. A. (2018). Trends in Hospice Discharge and Relative Outcomes Among Medicare Patients in the Get With The Guidelines-Heart Failure Registry. Jama Cardiol, 3(10), 917–926. https://doi.org/10.1001/jamacardio.2018.2678
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    • Echouffo-Tcheugui, J. B., Xu, H., Matsouaka, R. A., Xian, Y., Schwamm, L. H., Smith, E. E., … Fonarow, G. C. (2018). Diabetes and long-term outcomes of ischaemic stroke: findings from Get With The Guidelines-Stroke. Eur Heart J, 39(25), 2376–2386. https://doi.org/10.1093/eurheartj/ehy036
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    • Ziaeian, B., Heidenreich, P. A., Xu, H., DeVore, A. D., Matsouaka, R. A., Hernandez, A. F., … Fonarow, G. C. (2018). Medicare Expenditures by Race/Ethnicity After Hospitalization for Heart Failure With Preserved Ejection Fraction. Jacc Heart Fail, 6(5), 388–397. https://doi.org/10.1016/j.jchf.2017.12.007
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    • Li, S., Fonarow, G. C., Mukamal, K., Xu, H., Matsouaka, R. A., Devore, A. D., & Bhatt, D. L. (2018). Sex and Racial Disparities in Cardiac Rehabilitation Referral at Hospital Discharge and Gaps in Long-Term Mortality. J Am Heart Assoc, 7(8). https://doi.org/10.1161/JAHA.117.008088
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    • Chang, L. L., Xu, H., DeVore, A. D., Matsouaka, R. A., Yancy, C. W., Fonarow, G. C., … Hernandez, A. F. (2018). Timing of Postdischarge Follow-Up and Medication Adherence Among Patients With Heart Failure. J Am Heart Assoc, 7(7). https://doi.org/10.1161/JAHA.117.007998
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    • Shah, K. S., Xu, H., Matsouaka, R. A., Bhatt, D. L., Heidenreich, P. A., Hernandez, A. F., … Fonarow, G. C. (2017). Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes. J Am Coll Cardiol, 70(20), 2476–2486. https://doi.org/10.1016/j.jacc.2017.08.074
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    • Reeves, M. J., Fonarow, G. C., Xu, H., Matsouaka, R. A., Xian, Y., Saver, J., … Smith, E. E. (2017). Is Risk-Standardized In-Hospital Stroke Mortality an Adequate Proxy for Risk-Standardized 30-Day Stroke Mortality Data? Findings From Get With The Guidelines-Stroke. Circ Cardiovasc Qual Outcomes, 10(10). https://doi.org/10.1161/CIRCOUTCOMES.117.003748
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    • Ziaeian, B., Heidenreich, P. A., Xu, H., DeVore, A. D., Matsouaka, R. A., Hernandez, A. F., … Fonarow, G. C. (2017). Race/Ethnic Differences in Outcomes Among Hospitalized Medicare Patients With Heart Failure and Preserved Ejection Fraction. Jacc Heart Fail, 5(7), 483–493. https://doi.org/10.1016/j.jchf.2017.02.012
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    • Xian, Y., Xu, H., Liang, L., Hernandez, A. F., Wang, T. Y., & Peterson, E. D. (2017). An Initial Evaluation of the Impact of Pokémon GO on Physical Activity. J Am Heart Assoc, 6(5). https://doi.org/10.1161/JAHA.116.005341
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    • Xian, Y., O’Brien, E. C., Liang, L., Xu, H., Schwamm, L. H., Fonarow, G. C., … Peterson, E. D. (2017). Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation. Jama, 317(10), 1057–1067. https://doi.org/10.1001/jama.2017.1371
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    • Xian, Y., Xu, H., Lytle, B., Blevins, J., Peterson, E. D., Hernandez, A. F., … Fonarow, G. C. (2017). Use of Strategies to Improve Door-to-Needle Times With Tissue-Type Plasminogen Activator in Acute Ischemic Stroke in Clinical Practice: Findings from Target: Stroke. Circ Cardiovasc Qual Outcomes, 10(1). https://doi.org/10.1161/CIRCOUTCOMES.116.003227
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    • Echouffo-Tcheugui, J. B., Xu, H., DeVore, A. D., Schulte, P. J., Butler, J., Yancy, C. W., … Fonarow, G. C. (2016). Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The Guidelines-Heart Failure registry. Am Heart J, 182, 9–20. https://doi.org/10.1016/j.ahj.2016.07.025
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    • Pandey, A., Golwala, H., Xu, H., DeVore, A. D., Matsouaka, R., Pencina, M., … Fonarow, G. C. (2016). Association of 30-Day Readmission Metric for Heart Failure Under the Hospital Readmissions Reduction Program With Quality of Care and Outcomes. Jacc Heart Fail, 4(12), 935–946. https://doi.org/10.1016/j.jchf.2016.07.003
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    • Medford-Davis, L. N., Fonarow, G. C., Bhatt, D. L., Xu, H., Smith, E. E., Suter, R., … Schwamm, L. H. (2016). Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke. J Am Heart Assoc, 5(11). https://doi.org/10.1161/JAHA.116.004282
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    • Himes, J. E., Ho, C., Nguyen, Q. N., Amos, J. D., Xu, H., Chan, C., … Permar, S. R. (2016). Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys. J Virol, 90(19), 8795–8808. https://doi.org/10.1128/JVI.00701-16
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    • O’Brien, E. C., Xian, Y., Xu, H., Wu, J., Saver, J. L., Smith, E. E., … Fonarow, G. C. (2016). Hospital Variation in Home-Time After Acute Ischemic Stroke: Insights From the PROSPER Study (Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research). Stroke, 47(10), 2627–2633. https://doi.org/10.1161/STROKEAHA.116.013563
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  • Conference Papers

    • Kumar, N., Xu, H., Garg, N., Pandey, A., Matsouaka, R. A., Field, M. E., … Fonarow, G. C. (2021). Patient Characteristics, Care Patterns, and Outcomes of Atrial Fibrillation Associated Hospitalizations in Patients with Chronic Kidney Disease and End-Stage Renal Disease. In Am Heart J. United States. https://doi.org/10.1016/j.ahj.2021.06.012
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    • Akbik, F., Xu, H., Xian, Y., Shah, S., Smith, E. E., Bhatt, D. L., … Schwamm, L. H. (2020). Intravenous Thrombolysis for In-Hospital Ischemic Stroke in the Endovascular Era: Findings From the National Get With the Guidelines-Stroke Registry. In Stroke (Vol. 51).
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    • Schwamm, L. H., Xu, H., Matsouaka, R., Shah, S., Zachrison, K., Smith, E., … Saver, J. (2020). Use, Characteristics, and Outcomes of Endovascular Thrombectomy in Acute Ischemic Stroke Patients Beyond 6 Hours of Stroke Onset in US Clinical Practice. In Stroke (Vol. 51).
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    • Sayeed, S., Fudim, M., Xu, H., Matsouaka, R., Heidenreich, P. A., Yancy, C. W., … DeVore, A. D. (2019). Representativeness of the PIONEER-HF Clinical Trial Population in Patients Hospitalized with Heart Failure. In Journal of Cardiac Failure (Vol. 25, pp. S151–S151). Elsevier BV. https://doi.org/10.1016/j.cardfail.2019.07.436
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    • Luo, N., Hammill, B., DeVore, A., Xu, H., Fonarow, G., Hernandez, A., … Mentz, R. (2019). ASSOCIATION BETWEEN ASSIGNMENT TO AN ACCOUNTABLE CARE ORGANIZATION AND QUALITY OF CARE AND OUTCOMES AMONG MEDICARE BENEFICIARIES HOSPITALIZED FOR HEART FAILURE. In Journal of the American College of Cardiology (Vol. 73, pp. 913–913). Elsevier BV. https://doi.org/10.1016/s0735-1097(19)31520-7
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    • Shah, S., Xu, H., Xian, Y., Maisch, L., Hannah, D., Lindholm, B., … O’Brien, E. C. (2018). Patterns of Discharge Antidepressant Therapy Use After Acute Ischemic Stroke: Insights From the Prosper Study. In Stroke (Vol. 49). Los Angeles, CA: LIPPINCOTT WILLIAMS & WILKINS.
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    • Chang, L. L., Xu, H., DeVore, A. D., Matsouaka, R., Yancy, C., Fonarow, G. C., … Hernandez, A. F. (2017). Timing of Postdischarge Follow-Up and Medication Adherence Among Heart Failure Patients. In Circulation (Vol. 136). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS.
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    • Luo, N., Xu, H., Jneid, H., Fonarow, G. C., Lopes, R. D., Granger, C. B., … Al-Khatib, S. M. (2017). High Use of Oral Anticoagulation in Eligible Patients Discharged With Heart Failure and Atrial Fibrillation Irrespective of Ejection Fraction: Insights From the AHA Get With The Guidelines- Atrial Fibrillation Program. In Circulation (Vol. 136). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS.
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    • Shah, K. S., Xu, H., Matsouaka, R. A., Bhatt, D. L., Heidenreich, P. A., Hernandez, A. F., … Fonarow, G. C. (2017). Five-Year Outcomes in Patients Hospitalized With Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction in the Medicare Population. In Circulation (Vol. 136). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS.
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    • Xu, H., Xian, Y., Liang, L., Hernandez, A. F., Wang, T. Y., & Peterson, E. D. (2017). Does Pokemon Go Help Players be More Active? An Evaluation of Pokemon Go and Physical Activity. In Circulation (Vol. 135). Portland, OR: LIPPINCOTT WILLIAMS & WILKINS.
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    • Dandapat, S., Siddiqui, F. M., Fonarow, G. C., Bhatt, D. L., Xu, H., Matsouaka, R., … Smith, E. E. (2017). Lower Hemoglobin A1c is Associated With Higher In-Hospital Mortality in Intracerebral Hemorrhage. In Stroke (Vol. 48).
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    • Pandey, A., Golwala, H., Xu, H., DeVore, A., Matsouaka, R., Pencina, M., … Fonarow, G. (2016). Association of Risk Adjusted 30 Day Heart Failure Readmission Rates Under the Hospital Readmissions Reduction Program With Quality of Care and Outcomes: Findings From the American Heart Association Get With the Guidelines-Heart Failure Program. In Circulation (Vol. 134). Pentagon City, VA: LIPPINCOTT WILLIAMS & WILKINS.
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