Victor Hasselblad

Journal article Thromb Res · 2006 Featured Publication INTRODUCTION: Thrombin, a pluripotential effector enzyme with prothrombotic, proinflammatory, and mitogenic properties, plays a pivotal role in the pathobiology and clinical expression of atherothrombotic coronary artery disease. Existing anticoagulant dru ... Full text Link to item Cite

Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials.

Journal article JAMA · October 5, 2005 Featured Publication CONTEXT: Randomized clinical trials (RCTs) evaluating the pulmonary artery catheter (PAC) have been limited by small sample size. Some nonrandomized studies suggest that PAC use is associated with increased morbidity and mortality. OBJECTIVE: To estimate t ... Full text Link to item Cite

Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial.

Journal article JAMA · October 5, 2005 Featured Publication CONTEXT: Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients. OBJECTIVE: To determine whether PAC use is safe and ... Full text Link to item Cite

The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF).

Journal article Am J Cardiol · September 19, 2005 Featured Publication Acute heart failure syndromes (AHFS) are related to several diseases affecting not only the heart but also the kidneys and blood vessels. Emerging evidence indicates that myocardial injury may also play a role in the pathophysiology of AHFS, as suggested b ... Full text Link to item Cite

Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trial.

Journal article J Am Soc Nephrol · July 2005 Featured Publication Complications related to inadequate volume management are common during hemodialysis. This trial tested the hypothesis that availability of an intradialytic blood volume monitoring (IBVM) device improves fluid removal, reducing morbidity. A six-center, ran ... Full text Link to item Cite

Diabetes-related knowledge, atherosclerotic risk factor control, and outcomes in acute coronary syndromes.

Journal article Am J Cardiol · June 1, 2005 Featured Publication Patients who have diabetes mellitus have 2 times the incidence of an acute coronary syndrome (ACS) and 2 times the mortality rate after ACS compared with patients who do not have diabetes. Poor patient understanding of diabetes is believed to impede approp ... Full text Link to item Cite

Intensity and focus of heart failure disease management after hospital discharge.

Journal article Am Heart J · April 2005 Featured Publication BACKGROUND: Although features of heart failure disease management programs are broadly outlined, little is known about which interventions are actually used in the outpatient setting or which patients are most likely to require interventions. METHODS AND R ... Full text Link to item Cite

A perspective on trials comparing enoxaparin and unfractionated heparin in the treatment of non-ST-elevation acute coronary syndromes.

Journal article Am Heart J · April 2005 Featured Publication BACKGROUND: Non-ST-elevation (NSTE) acute coronary syndrome (ACS) is a serious, acute illness characterized by a high rate of death and morbid events, and antithrombin therapy is integral to its management. Contemporary guidelines from the American College ... Full text Link to item Cite

A systematic review of diabetes disease management programs.

Journal article Am J Manag Care · April 2005 Featured Publication OBJECTIVE: To systematically evaluate and synthesize published evidence regarding the effect of disease management programs for patients with diabetes mellitus on processes and outcomes of care. STUDY DESIGN: Systematic literature review and meta-analysis. ... Link to item Cite

Metaanalysis and review of heart failure disease management randomized controlled clinical trials.

Journal article Am Heart J · April 2005 Featured Publication BACKGROUND: The medical community has turned to disease management (DM) to bridge the gap between proven therapies and clinical practice for patients with heart failure (HF). The aim of this study was to assess the effectiveness of DM programs in reducing ... Full text Link to item Cite

Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry.

Journal article J Card Fail · April 2005 Featured Publication BACKGROUND: Hospitalizations for decompensated heart failure are frequent. The Initiation Management Pre-discharge Assessment of Carvedilol Heart Failure (IMPACT-HF) registry collected observational data in patients hospitalized for worsening heart failure ... Full text Link to item Cite

Does disease management improve clinical and economic outcomes in patients with chronic diseases? A systematic review.

Journal article Am J Med · August 1, 2004 Featured Publication PURPOSE: To assess the clinical and economic effects of disease management in patients with chronic diseases. METHODS: Electronic databases were searched for English-language articles from 1987 to 2001. Articles were included if they used a systematic appr ... Full text Link to item Cite

Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial.

Journal article JAMA · July 7, 2004 Featured Publication CONTEXT: Enoxaparin or the combination of glycoprotein IIb/IIIa inhibitor tirofiban with unfractionated heparin independently have shown superior efficacy over unfractionated heparin alone in patients with non-ST-elevation acute coronary syndromes (ACS). I ... Full text Link to item Cite

Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview.

Journal article JAMA · July 7, 2004 Featured Publication CONTEXT: Antithrombin therapy has become a guidelines-recommended standard of care in the treatment of acute coronary syndromes (ACS), but recent trials comparing use of enoxaparin and unfractionated heparin in ACS have yielded less robust efficacy and saf ... Full text Link to item Cite

Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial).

Journal article Am J Cardiol · June 1, 2004 Featured Publication The relation of cardiac troponin-I (cTnI) to clinical outcomes was examined in patients with decompensated heart failure and concomitant acute coronary syndrome enrolled into the Randomized Intravenous TeZosentan 4 (RITZ-4) study. RITZ-4 was a multicenter, ... Full text Link to item Cite

Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial.

Journal article J Am Coll Cardiol · May 5, 2004 Featured Publication OBJECTIVES: The Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial was an investigator-initiated study to evaluate if predischarge carvedilol initiation in stabilized patients hospitalized fo ... Full text Link to item Cite

Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure.

Journal article Am J Cardiol · March 15, 2004 Featured Publication C-reactive protein (CRP) levels were measured in a cohort of 96 outpatients with heart failure. Baseline angiotensin-converting enzyme inhibitor plus beta-blocker use were associated with lower levels of CRP; no relation was found between CRP levels and as ... Full text Link to item Cite

Improved clinical outcomes with abciximab therapy in acute myocardial infarction: a systematic overview of randomized clinical trials.

Journal article Am Heart J · March 2004 Featured Publication BACKGROUND: Investigations of glycoprotein (GP) IIb/IIIa inhibition in primary percutaneous coronary intervention (PCI) have suggested the efficacy of abciximab in improving clinical and angiographic outcomes, but sample-size limitations and variability in ... Full text Link to item Cite

Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study).

Journal article Am J Cardiol · March 1, 2004 Featured Publication In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess me ... Full text Link to item Cite

Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis.

Journal article Am Heart J · March 2004 Featured Publication BACKGROUND: Elevated concentrations of cardiac troponin T (TnT) have been reported in patients hospitalized for decompensated heart failure (HF). We assessed whether elevated TnT levels are associated with the severity, etiology, and prognosis of HF in sta ... Full text Link to item Cite

Differential treatment benefit of platelet glycoprotein IIb/IIIa inhibition with percutaneous coronary intervention versus medical therapy for acute coronary syndromes: exploration of methods.

Journal article Circulation · February 10, 2004 Featured Publication BACKGROUND: Although many believe that platelet glycoprotein IIb/IIIa inhibitors should be used only in acute coronary syndrome patients undergoing percutaneous coronary intervention, supporting data from randomized clinical trials are tenuous. The assumpt ... Full text Link to item Cite

Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot.

Journal article J Thromb Haemost · February 2004 Featured Publication BACKGROUND: Direct factor (F)Xa inhibition is an attractive method to limit thrombotic complications during percutaneous coronary intervention (PCI). OBJECTIVES: To investigate drug levels achieved, effect on coagulation markers, and preliminary efficacy a ... Full text Link to item Cite

Effectiveness of disease management programs in depression: a systematic review.

Journal article Am J Psychiatry · December 2003 Featured Publication OBJECTIVE: The authors systematically evaluated the published evidence to assess the effectiveness of disease management programs in depression. METHOD: English-language articles on depression were identified through a MEDLINE search for the period from Ja ... Full text Link to item Cite

Revascularization in patients with coronary artery disease, left ventricular dysfunction, and viability: a meta-analysis.

Journal article Am Heart J · October 2003 Featured Publication BACKGROUND: The effects of viability status and treatment allocation on long-term mortality in patients with left ventricular dysfunction and coronary artery disease have not been determined. Several observational studies with significant limitations have ... Full text Link to item Cite

Meta-analysis of survival with platelet glycoprotein IIb/IIIa antagonists for percutaneous coronary interventions.

Journal article Am J Cardiol · September 15, 2003 Featured Publication We performed a cumulative meta-analysis of available studies to evaluate the effect of intravenous platelet glycoprotein (GP) IIb/IIIa antagonists on survival at 30 days and 6 months after percutaneous coronary intervention (PCI). Compounds that block the ... Full text Link to item Cite

Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).

Journal article Am J Cardiol · September 15, 2003 Featured Publication Myocardial ischemic injury complicating acute myocardial infarction (AMI) and coronary revascularization procedures remains an unresolved clinical dilemma. In preclinical studies, treatment with pyridoxal-5'-phosphate monohydrate (MC-1), a vitamin B6 metab ... Full text Link to item Cite

Evaluation of an infrared/radiofrequency equipment-tracking system in a tertiary care hospital.

Journal article J Med Syst · August 2003 Featured Publication Optimal management of assets in large hospitals is important to both cost control and patient care. A prospective controlled evaluation was conducted to determine whether an asset-tracking system using combined radiofrequency and infrared signals could inc ... Full text Link to item Cite

Power calculations for large multi-arm placebo-controlled studies of dichotomous outcomes.

Journal article Stat Med · June 30, 2003 Featured Publication Several statistical methods can be used to test for differences in placebo-controlled dichotomous multi-arm studies. These tests include linear and quadratic trends, Dunnett's test, Hochberg's test, and the overall chi-square test. We computed the power of ... Full text Link to item Cite

Tocolytic treatment for the management of preterm labor: a review of the evidence.

Journal article Am J Obstet Gynecol · June 2003 Featured Publication OBJECTIVE: Preterm labor is often a prelude to early births and the significant attendant burden of infant morbidity and mortality. Treatment consists of bedrest, hydration, pharmacologic interventions, and combinations of these. We systematically reviewed ... Full text Link to item Cite

Comparison of 30-day outcome, resource use, and coronary artery disease severity in patients with suspected coronary artery disease with and without diabetes mellitus assigned to chest pain units.

Journal article Am J Cardiol · May 15, 2003 Featured Publication Full text Link to item Cite

Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4).

Journal article J Am Coll Cardiol · May 7, 2003 Featured Publication OBJECTIVES: We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated with acute coronary syndrome (ACS). BACKGROUND: Tezosentan is a dual endothelin receptor antagonist that has been shown to improv ... Full text Link to item Cite

Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes.

Journal article Am J Cardiol · April 15, 2003 Featured Publication The risk of death or recurrent myocardial infarction (MI) in patients with chest pain and baseline isolated troponin elevation is unclear. To determine the early and short-term risk of death or MI associated with isolated troponin elevation across a spectr ... Full text Link to item Cite

Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients.

Journal article J Am Coll Cardiol · February 5, 2003 Featured Publication OBJECTIVES: Our primary objective was to examine the prognostic relationship between baseline quantitative ST-segment depression (ST) and cardiac troponin T (cTnT) elevation. The secondary objectives were to: 1) examine whether ST provided additional insig ... Full text Link to item Cite

Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making.

Journal article Eur Heart J · January 2003 Featured Publication AIMS: We evaluated timing of adverse cardiac events after thrombolysis to guide length of stay after ST-segment elevation myocardial infarction. METHODS AND RESULTS: Kaplan-Meier survival curves described timing of major postinfarction complications in 410 ... Full text Link to item Cite

Evaluation of a tool to categorize patients by reading literacy and computer skill to facilitate the computer-administered patient interview.

Journal article AMIA Annu Symp Proc · 2003 Featured Publication Past efforts to collect clinical information directly from patients using computers have had limited utility because these efforts required users to be literate and facile with the computerized information collecting system. In this paper we describe the c ... Link to item Cite

Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries: a meta-analysis.

Journal article Circulation · November 12, 2002 Featured Publication BACKGROUND: Prior studies of coronary pattern and outcome after arterial switch operation (ASO) for transposition of the great arteries (TGA) have been hindered by limited statistical power. This meta-analysis assesses the effect of coronary anatomy on pos ... Full text Link to item Cite

Interventions used in disease management programmes for patients with chronic illness-which ones work? Meta-analysis of published reports.

Journal article BMJ · October 26, 2002 Featured Publication OBJECTIVE: To systematically evaluate the published evidence regarding the characteristics and effectiveness of disease management programmes. DESIGN: Meta-analysis. DATA SOURCES: Computerised databases for English language articles during 1987-2001. STUDY ... Full text Link to item Cite

Seeking the optimal aspirin dose in acute coronary syndromes.

Journal article Am J Cardiol · September 15, 2002 Featured Publication Full text Link to item Cite

Role of target vessel size and body surface area on outcomes after percutaneous coronary interventions in women.

Journal article Am Heart J · August 2002 Featured Publication BACKGROUND: Women have higher mortality rates than men after coronary angioplasty. Differences in target vessel size may partially account for these differences. We set out to explore the effects of sex, body surface area (BSA), and target coronary vessel ... Full text Link to item Cite

Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma.

Journal article Cancer · July 15, 2002 Featured Publication BACKGROUND: The current systematic review and meta-analysis compared monotherapy and combined androgen blockade in the treatment of men with advanced prostate carcinoma. Outcomes of interest included overall, cancer specific, and progression-free survival; ... Full text Link to item Cite

Prognostic significance of elevated troponin I after percutaneous coronary intervention.

Journal article J Am Coll Cardiol · June 5, 2002 Featured Publication OBJECTIVES: We sought to assess the incidence and clinical significance of elevated cardiac troponin I (cTnI) after percutaneous coronary intervention (PCI). BACKGROUND: Elevated creatine kinase-MB (CK-MB) is prognostically important after PCI, but the pro ... Full text Link to item Cite

The failure of orally administered glycoprotein IIb/IIIa inhibitors to prevent recurrent cardiac events.

Journal article Am J Med · June 1, 2002 Featured Publication PURPOSE: Despite the success of intravenous glycoprotein IIb/IIIa antagonists, oral formulations have failed to show benefit and have been associated with increased mortality. To understand these findings, we performed a meta-analysis of results from four ... Full text Link to item Cite

Benefits of smoking cessation for longevity.

Journal article Am J Public Health · June 2002 Featured Publication OBJECTIVES: This study determined the life extension obtained from stopping smoking at various ages. METHODS: We estimated the relation between smoking and mortality among 877,243 respondents to the Cancer Prevention Study II. These estimates were applied ... Full text Link to item Cite

Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes?

Journal article Am Heart J · June 2002 Featured Publication OBJECTIVES: We sought to determine whether platelet activity in patients with heart failure is related to an ischemic versus nonischemic etiologic condition, clinical disease severity, or adverse clinical outcomes. BACKGROUND: Platelet activity may affect ... Full text Link to item Cite

Dissociation between hemodynamic changes and symptom improvement in patients with advanced congestive heart failure.

Journal article Eur J Heart Fail · June 2002 Featured Publication BACKGROUND: Changes in hemodynamic measures often serve as surrogate end points in efficacy trials for advanced heart failure, although there are few objective data to support this practice. AIMS: We compared changes in hemodynamic variables vs. changes in ... Full text Link to item Cite

First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation.

Journal article Circulation · May 21, 2002 Featured Publication BACKGROUND: Thrombin generation is critical to the formation of an arterial thrombus after rupture of an atherosclerotic plaque. In patients with stable coronary disease receiving standard medical therapy, we evaluated the pharmacokinetics, pharmacodynamic ... Full text Link to item Cite

Patients with CHF and depression have greater risk of mortality and morbidity than patients without depression.

Journal article J Am Coll Cardiol · March 6, 2002 Featured Publication Full text Link to item Cite

Antibiotic therapy for the treatment of preterm labor: a review of the evidence.

Journal article Am J Obstet Gynecol · March 2002 Featured Publication OBJECTIVE: The purpose of this study was to evaluate the evidence regarding antibiotics for the treatment of preterm labor. STUDY DESIGN: Through dual review, we abstracted study design and masking, definitions of preterm labor and pregnancy outcome, patie ... Full text Link to item Cite

A randomized, placebo-controlled trial of enoxaparin after high-risk coronary stenting: the ATLAST trial.

Journal article J Am Coll Cardiol · November 15, 2001 Featured Publication OBJECTIVES: We performed a multicenter, double-blind placebo-controlled trial to examine the efficacy and safety of enoxaparin in patients at high risk for stent thrombosis (ST). BACKGROUND: The optimal antithrombotic regimen for such patients is unknown. ... Full text Link to item Cite

Prognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy.

Journal article Am J Cardiol · November 1, 2001 Featured Publication Clinicians have relied on history and results from physical examinations to guide treatment of patients with advanced congestive heart failure, but these results may not reflect disease severity or hemodynamic status. We assessed how the distance walked in ... Full text Link to item Cite

Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey.

Journal article Blood · October 15, 2001 Featured Publication In previous analyses of transferrin saturation data in African Americans and Caucasians from the second National Health and Nutrition Examination Survey (NHANES II), subpopulations were found consistent with population genetics for common loci that influen ... Full text Link to item Cite

Epoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials.

Journal article J Natl Cancer Inst · August 15, 2001 Featured Publication Epoetin treatment offers an attractive but costly alternative to red blood cell transfusion for managing anemia associated with cancer therapy. The goal of this review is to facilitate more efficient use of epoetin by 1) quantifying the effects of epoetin ... Full text Link to item Cite

Assessing the clinical and economic burden of coronary artery disease: 1986-1998.

Journal article Med Care · August 2001 Featured Publication BACKGROUND: The acute phase of coronary artery disease (CAD) is dramatic and receives much attention because of its high mortality and associated treatment cost. However, the acute phase typically resolves within 30 days whereas CAD is a chronic disease, w ... Full text Link to item Cite

Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy.

Journal article Circulation · June 19, 2001 Featured Publication BACKGROUND: Troponin T (TnT) is valuable for short- and long-term risk stratification of patients with acute coronary syndromes (ACS). It also may predict which ACS patients will benefit from glycoprotein (GP) IIb/IIIa blockade. METHODS AND RESULTS: We pro ... Full text Link to item Cite

Medicine. Placebo-controls in short-term clinical trials of hypertension.

Journal article Science · June 15, 2001 Featured Publication Full text Link to item Cite

Hemodynamic profiles of advanced heart failure: association with clinical characteristics and long-term outcomes.

Journal article J Card Fail · June 2001 Featured Publication BACKGROUND: Classifying patients with advanced congestive heart failure (CHF) by baseline measures of congestion and perfusion has been used to estimate hemodynamic status and to select and titrate therapy. We describe clinical characteristics of 4 hemodyn ... Full text Link to item Cite

Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial.

Journal article JAMA · May 16, 2001 Featured Publication CONTEXT: The Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy (ESPRIT) trial showed the efficacy of adjunctive, double-bolus eptifibatide therapy in reducing ischemic complications of nonurgent coronary stent implantation at 4 ... Full text Link to item Cite

Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE): design and rationale.

Journal article Am Heart J · April 2001 Featured Publication BACKGROUND: There is little information about how to adjust pharmacologic agents in the treatment of patients with advanced congestive heart failure (CHF). Some studies have suggested that use of pulmonary artery catheterization to guide reductions in fill ... Full text Link to item Cite

Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes.

Journal article J Am Coll Cardiol · March 15, 2001 Featured Publication OBJECTIVES: We sought to determine the incidence of and risk factors for thrombotic events early after discontinuing antithrombin therapy in patients with acute coronary syndromes. BACKGROUND: Discontinuation of treatment with heparin and other thrombin in ... Full text Link to item Cite

Uses of epoetin for anemia in oncology.

Journal article Evid Rep Technol Assess (Summ) · March 2001 Featured Publication Link to item Cite

Reply.

Other J AAPOS · December 2000 Featured Publication Full text Link to item Cite

Management of preterm labor.

Journal article Evid Rep Technol Assess (Summ) · October 2000 Featured Publication Link to item Cite

Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review.

Journal article Ann Intern Med · May 16, 2000 Featured Publication PURPOSE: To evaluate the accuracy of conventional and new methods of Papanicolaou (Pap) testing when used to detect cervical cancer and its precursors. DATA SOURCES: Systematic search of English-language literature through October 1999 using MEDLINE, EMBAS ... Full text Link to item Cite

Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis.

Journal article Ann Intern Med · April 4, 2000 Featured Publication PURPOSE: To compare luteinizing hormone-releasing hormone (LHRH) agonists with orchiectomy or diethylstilbestrol, and to compare antiandrogens with any of these three alternatives. DATA SOURCES: A search of the MEDLINE, Cancerlit, EMBASE, and Cochrane Libr ... Full text Link to item Cite

Does primary intraocular lens implantation prevent "aphakic" glaucoma in children?

Journal article J AAPOS · February 2000 Featured Publication PURPOSE: Open-angle glaucoma may develop after surgery for congenital or developmental cataract with an incidence ranging from 3% to 41%. The pathogenesis of "aphakic" (open-angle) glaucoma remains unknown. Despite numerous reported clinical series (>1000 ... Full text Link to item Cite

The results of a randomized controlled trial of hydrocortisone in acute exacerbation of COPD.

Journal article Am J Emerg Med · January 2000 Featured Publication Full text Link to item Cite

Clinical outcomes of bivalirudin for ischemic heart disease.

Journal article Circulation · November 16, 1999 Featured Publication BACKGROUND: Current treatment strategies for percutaneous coronary revascularization and acute coronary syndromes incorporate thrombin inhibition with either unfractionated or fractionated heparin. The peptide bivalirudin (Hirulog) is a direct thrombin inh ... Full text Link to item Cite

Assessment of human exposure to ambient particulate matter.

Journal article J Air Waste Manag Assoc · November 1999 Featured Publication Recent epidemiological studies have consistently shown that the acute mortality effects of high concentrations of ambient particulate matter (PM), documented in historic air pollution episodes, may also be occurring at the low to moderate concentrations of ... Full text Link to item Cite

Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study.

Journal article Arch Intern Med · September 13, 1999 Featured Publication BACKGROUND: The multidisciplinary approach to managing heart failure has been shown to improve outcomes. The role of a clinical pharmacist in treating heart failure has not been evaluated. METHODS: One hundred eighty-one patients with heart failure and lef ... Full text Link to item Cite

Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis.

Journal article Obstet Gynecol · May 1999 Featured Publication OBJECTIVE: To review systematically the association between hormone replacement therapy (HRT) and the risk of developing or dying from colorectal cancer. DATA SOURCES: We searched the English-language literature using MEDLINE, Current Contents, CancerLit, ... Full text Link to item Cite

Relative effectiveness and cost-effectiveness of methods of androgen suppression in the treatment of advanced prostate cancer.

Journal article Evid Rep Technol Assess (Summ) · May 1999 Featured Publication OBJECTIVES: With 184,500 new cases and 39,200 deaths anticipated in 1998, prostate cancer is second only to lung cancer in cancer mortality for men. This report is a systematic review of the evidence from randomized controlled trials on the relative effect ... Link to item Cite

Patient Outcomes Research Teams: contribution to outcomes and effectiveness research.

Journal article Annu Rev Public Health · 1999 Featured Publication This paper describes the key methodological and substantive findings of Patient Outcomes Research Teams, the first outcomes and effectiveness research centers funded by the Agency for Health Care Policy and Research. Patient Outcomes Research Teams contrib ... Full text Link to item Cite

Evaluation of cervical cytology.

Journal article Evid Rep Technol Assess (Summ) · January 1999 Featured Publication Link to item Cite

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Journal article Circulation · December 22, 1998 Featured Publication BACKGROUND: Several platelet glycoprotein (GP) IIb/IIIa receptor antagonists have been evaluated in clinical trials. We conducted a systematic overview (meta-analysis) to assess the effect of these compounds on death, myocardial infarction (MI), and revasc ... Full text Link to item Cite

Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis.

Journal article Prim Care Update Ob Gyns · July 1, 1998 Featured Publication Objective: To review systematically the association between hormone replacement therapy and colorectal cancer incidence and mortality.Methods: We conducted a literature search of English-language studies using MEDLINE, Current Contents, CancerLit, and bibl ... Full text Link to item Cite

Is optimal angiotensin-converting enzyme inhibitor dosing neglected in elderly patients with heart failure?

Journal article Am Heart J · July 1998 Featured Publication BACKGROUND: The benefit of angiotensin-converting enzyme (ACE) inhibitors on mortality in heart failure has been proved in randomized controlled trials. METHODS: We prospectively evaluated the prescribing of ACE inhibitors and the prescribing of target ACE ... Full text Link to item Cite

The Agency for Health Care Policy and Research Smoking Cessation Clinical Practice Guideline. Findings and implications for psychologists.

Journal article Am Psychol · June 1998 Featured Publication Smoking is the leading cause of preventable morbidity and mortality in the United States, and the health benefits of quitting smoking are substantial. Nevertheless, over 25% of American adults (48 million individuals) continue to smoke, and the vast majori ... Full text Link to item Cite

Failure of the mandatory domestic violence reporting law to increase medical facility referral to police.

Journal article Ann Emerg Med · April 1998 Featured Publication STUDY OBJECTIVE: To assess the effect of California's 1994 mandatory domestic violence reporting law on Los Angeles Sheriff's Department dispatches to medical facilities for domestic violence incidents. METHODS: This ecological time-trend study analyzed da ... Full text Link to item Cite

Distribution of transferrin saturations in the African-American population.

Journal article Blood · March 15, 1998 Featured Publication To determine if transferrin saturations in African Americans may reflect the presence of a gene that influences iron metabolism, we analyzed the distribution of these values in 808 African Americans from the second National Health and Nutrition Survey. We ... Link to item Cite

Diagnostic efficiency of home pregnancy test kits. A meta-analysis.

Journal article Arch Fam Med · 1998 Featured Publication OBJECTIVE: To assess the diagnostic efficiency of home pregnancy test (HPT) kits. DATA SOURCES: A literature search of English-language studies was performed with MEDLINE and a review of bibliographies. STUDY SELECTION: Studies were included if HPT kits we ... Full text Link to item Cite

Meta-analysis of multitreatment studies.

Journal article Med Decis Making · 1998 Featured Publication Studies comparing more than two competing therapies are common in several fields, but standard meta-analytic methods can make only pairwise comparisons. The methods proposed in this article, a generalization of current meta-analytic methods, allow for any ... Full text Link to item Cite

Predicting the cost of illness: a comparison of alternative models applied to stroke.

Journal article Med Decis Making · 1998 Featured Publication Predictions of cost over well-defined time horizons are frequently required in the analysis of clinical trials and social experiments, for decision models investigating the cost-effectiveness of interventions, and for macro-level estimates of the resource ... Full text Link to item Cite

Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation. Agency for Health Care Policy and Research.

Journal article JAMA · December 3, 1997 Featured Publication CONTEXT: The Agency for Health Care Policy and Research (AHCPR) published the Smoking Cessation: Clinical Practice Guideline in 1996. Based on the results of meta-analyses and expert opinion, the guideline identifies efficacious interventions for primary c ... Link to item Cite

The Stroke Prevention Policy Model: linking evidence and clinical decisions.

Journal article Ann Intern Med · October 15, 1997 Featured Publication Simulation models that support decision and cost-effectiveness analysis can further the goals of evidence-based medicine by facilitating the synthesis of information from several sources into a single comprehensive structure. The Stroke Prevention Policy M ... Full text Link to item Cite

Pediatric Vesicoureteral Reflux Guidelines Panel summary report on the management of primary vesicoureteral reflux in children.

Journal article J Urol · May 1997 Featured Publication PURPOSE: The American Urological Association convened the Pediatric Vesicoureteral Reflux Guidelines Panel to analyze the literature regarding available methods for treating vesicoureteral reflux diagnosed following a urinary tract infection in children an ... Link to item Cite

Assessing uncertainty in cost-effectiveness analyses: application to a complex decision model.

Journal article Med Decis Making · 1997 Featured Publication A framework for quantifying uncertainty about costs, effectiveness measures, and marginal cost-effectiveness ratios in complex decision models is presented. This type of application requires special techniques because of the multiple sources of information ... Full text Link to item Cite

A metaanalysis of predischarge risk stratification after acute myocardial infarction with stress electrocardiographic, myocardial perfusion, and ventricular function imaging.

Journal article Am J Cardiol · December 15, 1996 Featured Publication We assessed the relation of abnormal predischarge non-invasive test results to outcomes in postmyocardial infarction patients. We included series published from 1980 to 1995 containing only myocardial infarction patients, enrolling most patients after 1980 ... Full text Link to item Cite

A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Hemoglobin Levels.

Journal article JAMA · October 16, 1996 Featured Publication OBJECTIVE: To determine whether a glycosylated hemoglobin level can be used in place of an oral glucose tolerance test (OGTT) to diagnose diabetes. DATA SOURCES/STUDY SELECTION: An augmented MEDLINE search was performed to identify all reports from 1966 th ... Link to item Cite

Comparison and meta-analysis of randomized trials of endarterectomy for symptomatic carotid artery stenosis.

Journal article Neurology · November 1995 Featured Publication OBJECTIVE: Comparison and meta-analysis of randomized trials of carotid endarterectomy for symptomatic stenosis of the extracranial carotid artery. BACKGROUND: Randomized trials (North American Symptomatic Carotid Endarterectomy Trial [NASCET], the Europea ... Full text Link to item Cite

Prevalence of heterozygotes for hemochromatosis in the white population of the United States.

Journal article Blood · September 1, 1995 Featured Publication In previous studies, the prevalence of HLA-linked hemochromatosis, thought to be the most common genetic illness in whites, has been estimated by identifying homozygotes in the population. Because not all homozygotes express the disease phenotypically, the ... Link to item Cite

Noninvasive carotid artery testing. A meta-analytic review.

Journal article Ann Intern Med · March 1, 1995 Featured Publication PURPOSE: To compare the operating characteristics of six noninvasive tests for carotid artery stenosis. DATA SOURCES: A structured search was done using MEDLINE, reference lists from selected articles, and bibliographies from neurology textbooks that focus ... Full text Link to item Cite

A survey of current problems in meta-analysis. Discussion from the Agency for Health Care Policy and Research inter-PORT Work Group on Literature Review/Meta-Analysis.

Journal article Med Care · February 1995 Featured Publication The United States Agency for Health Care Policy and Research brought together representatives from each of the Patient Outcomes Research Teams (PORTs) as the Inter-PORT Meta-Analysis Work Group. The purpose of the meeting was to discuss a wide range of pro ... Link to item Cite

Meta-analysis of environmental health data.

Journal article Sci Total Environ · January 15, 1995 Featured Publication Most airborne contaminants have minimal health effects at typical ambient levels, and this is especially true for contaminant levels in the Arctic. Among multiple studies of similar health effects, usually only one or two of the studies show statistically ... Full text Link to item Cite

Meta-analytic tools for medical decision making: a practical guide.

Journal article Med Decis Making · 1995 Featured Publication This paper is an extension of notes used for the short course in meta-analysis given at the 13th and 14th annual meetings of the Society for Medical Decision Making. The material covers both standard and evolving methods of meta-analysis. The methods inclu ... Full text Link to item Cite

Meta-analysis of screening and diagnostic tests.

Journal article Psychol Bull · January 1995 Featured Publication Screening and diagnostic tests are common in the fields of psychology, medicine, and education. Often there are several competing tests, and decisions must be made about the relative accuracy of those tests. This article describes a general measure that ca ... Full text Link to item Cite

Synthesis of environmental evidence: nitrogen dioxide epidemiology studies.

Journal article J Air Waste Manage Assoc · May 1992 Featured Publication The use of meta-analysis is becoming more common in the medical literature, but it is not common in the environmental literature. Although meta-analysis cannot combine a group of poorly executed, conflicting studies to get an unequivocal answer, there are ... Full text Link to item Cite

An introduction to a Bayesian method for meta-analysis: The confidence profile method.

Journal article Med Decis Making · 1990 Featured Publication The Confidence Profile Method is a new Bayesian method that can be used to assess technologies where the available evidence involves a variety of experimental designs, types of outcomes, and effect measures; a variety of biases; combinations of biases and ... Full text Link to item Cite

A Bayesian method for synthesizing evidence. The Confidence Profile Method.

Journal article Int J Technol Assess Health Care · 1990 Featured Publication This article describes a collection of meta-analysis techniques based on Bayesian statistics for interpreting, adjusting, and combining evidence to estimate parameters and outcomes important to the assessment of health technologies. The result of an analys ... Full text Link to item Cite

The value of mammography screening in women under age 50 years.

Journal article JAMA · March 11, 1988 Featured Publication Two quantitative methods, Confidence Profiles and CAN*TROL, are used to analyze evidence and estimate the health and economic consequences of adding annual mammography to annual breast physical examinations in asymptomatic women aged 40 to 49 years who are ... Link to item Cite

Air pollution and morbidity: a further analysis of the Los Angeles student nurses data.

Journal article JAPCA · February 1988 Featured Publication Full text Link to item Cite

Statistical and graphical evaluation of erythrocyte volume distributions.

Journal article Am J Physiol · April 1987 Featured Publication A protocol for the statistical and graphical evaluation of erythrocyte volume distributions has been developed using expectation-maximization methods for distribution parameter estimation. In a reference sample group of 50 healthy individuals, none of the ... Full text Link to item Cite

Adequacy of a single monitoring site for defining mean outdoor concentrations of fine particles in a demarcated residential community.

Journal article JAPCA · April 1987 Featured Publication Full text Link to item Cite

Analysis of the volume of red blood cells: application of the expectation-maximization algorithm to grouped data from the doubly-truncated lognormal distribution.

Journal article Biometrics · March 1986 Featured Publication In accordance with general principles recommended by the International Committee for Standardization in Haematology (1982, Journal of Clinical Pathology 35, 1320-1322), we have developed statistical methods for the analysis of red cell volume distributions ... Link to item Cite

A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation.

Journal article Prog Clin Biol Res · 1986 Featured Publication Link to item Cite

Prevalence of persistent cough and phlegm in young adults in relation to long-term ambient sulfur oxide exposure.

Journal article Am Rev Respir Dis · August 1985 Featured Publication In early 1976, a survey of persistent cough and phlegm (PCP) prevalence was conducted in 5,623 young adults in 4 Utah communities. Over the previous 5 years, community-specific mean sulfur dioxide levels had been 11, 18, 36, and 115 micrograms/m3. Correspo ... Full text Link to item Cite

Indoor environmental determinants of lung function in children.

Journal article Am Rev Respir Dis · May 1981 Featured Publication Using pulmonary function and family respiratory questionnaire data for 16,689 white children 6 to 13 yr of age from 7 geographic areas, the investigators examined the effect of several environmental and other factors on performance, in a standard test of b ... Full text Link to item Cite

Modeling the Ames test.

Journal article Mutat Res · February 1981 Featured Publication Despite the value and widespread use of the Ames test, little attention has been focused on standardizing quantitative methods of analyzing these data. In this paper, a realistic and statistically tractable model is developed for the evaluation of Ames-typ ... Full text Link to item Cite

Spirometric changes in normal children with upper respiratory infections.

Journal article Am Rev Respir Dis · January 1978 Featured Publication Recent evidence that certain uncomplicated upper respiratory infections induce pulmonary function abnormalities in adults prompted a prospective study in children, in whom such infections occur more frequently. In a longitudinal study, 55 children 2.5 to 1 ... Full text Link to item Cite

Additional analyses of the seven city lead study.

Journal article Environ Qual Saf Suppl · 1975 Featured Publication Link to item Cite

Los Angeles student nurse study. Daily symptom reporting and photochemical oxidants.

Journal article Arch Environ Health · May 1974 Featured Publication Full text Link to item Cite

Cadmium and lead in autopsy tissues.

Journal article J Occup Med · December 1973 Featured Publication Link to item Cite

Air pollution effects on ventilatory function of US schoolchildren. Results of studies in Cincinnati, Chattanooga, and New York.

Journal article Arch Environ Health · September 1973 Featured Publication Full text Link to item Cite