Scholars@Duke
Laura Jean Havrilesky

Laura Jean Havrilesky

Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Gynecologic Oncology
laura.havrilesky@duke.edu
Box 3079 Med Ctr, Durham, NC 27710
25172 Morris Bldg, Durham, NC 27710

Scholarly Works - Journal articles

Better at home: A quality improvement initiative to increase same day discharge after minimally invasive hysterectomies in gynecologic oncology.

Journal article Gynecol Oncol Rep · August 2026 OBJECTIVE: To increase the rate of same-day discharge after minimally invasive hysterectomy. METHODS: A quality improvement initiative was implemented at a large academic medical center for patients undergoing minimally invasive hysterectomy by a gynecolog ... Full text Link to item Cite

Endometrial thickness in patients with postmenopausal bleeding and endometrial cancer: A retrospective cohort study.

Journal article Gynecol Oncol Rep · August 2026 OBJECTIVE: Updated ACOG guidelines recommend a combined approach of transvaginal ultrasound (TVUS) and endometrial sampling for evaluation of most postmenopausal bleeding (PMB). Although prior studies investigating the reliability of TVUS suggest that non- ... Full text Link to item Cite

A prospective algorithm for pre-operative risk stratification and individualized lymph node assessment in patients with endometrial intraepithelial neoplasia (EIN)

Journal article Gynecologic Oncology Reports · August 1, 2026 Objectives: The standard of care surgical management of endometrial intraepithelial neoplasia (EIN) is debated. Because EIN carries a 35–40% risk of underlying carcinoma, omission of lymph node sampling can result in incomplete staging. However, lymph node ... Full text Cite

A phase 2 study of pembrolizumab and weekly paclitaxel for platinum-resistant epithelial ovarian cancer.

Journal article Int J Gynecol Cancer · June 2026 OBJECTIVE: Weekly dose-dense paclitaxel may have immunomodulatory effects, enhancing immune responses via cytotoxic T-cell infiltration. Therefore, we assessed the combination of weekly dose-dense paclitaxel with pembrolizumab in patients with platinum-res ... Full text Link to item Cite

Randomized clinical trial of an Acceptance and Commitment Therapy telehealth intervention ('REVITALIZE') to reduce fatigue interference in women with advanced ovarian cancer on PARP inhibitors: study protocol.

Journal article BMC Cancer · April 2, 2026 BACKGROUND: In the era of precision oncology, patients with advanced cancer are often living longer but are enduring years of fatiguing treatment. Fatigue is among the most common, chronic, and under-addressed side effects of advanced cancer treatment, and ... Full text Link to item Cite

Comparative Modeling of Recent and Projected Trends in the Incidence and Mortality of Uterine Cancer.

Journal article Obstet Gynecol · April 1, 2026 OBJECTIVE: To aid in cancer control and prevention activities by developing, calibrating, and validating three distinct natural history simulation models of uterine cancer, a growing public health concern. METHODS: To perform comparative analyses, we devel ... Full text Link to item Cite

Cost and efficiency of universal versus selective next generation sequencing for advanced stage endometrial cancer.

Journal article Gynecol Oncol · April 2026 OBJECTIVE: We sought to identify efficient tumor molecular profiling strategies for patients with newly diagnosed stage III-IVA endometrial cancer. METHODS: We constructed a decision tree model to compare molecular profiling strategies. We considered testi ... Full text Link to item Cite

Performance of ultrasound and rates of guideline-concordant care in a diverse postmenopausal bleeding cohort.

Journal article Am J Obstet Gynecol · February 2026 BACKGROUND: Professional society guidelines endorse the use of ultrasound to evaluate an initial episode of postmenopausal bleeding, with endometrial sampling reserved for patients with an endometrial thickness exceeding 4 mm. However, the data supporting ... Full text Link to item Cite

Neoadjuvant Chemotherapy Versus Primary Cytoreductive Surgery for Metastatic Endometrial Cancer.

Journal article Cancer Med · January 2026 OBJECTIVE: To evaluate the pattern of use and clinical outcomes associated with neoadjuvant chemotherapy (NACT) compared with primary debulking surgery (PDS) in patients with stage IV endometrial cancer. METHODS: We utilized the National Cancer Database to ... Full text Link to item Cite

Cost-effectiveness of biomarker-based and universal strategies for the treatment of advanced-stage endometrial cancer.

Journal article Gynecol Oncol · December 2025 OBJECTIVE: To compare cost-effectiveness of targeted therapeutic strategies for non-Hispanic Black (NHB) and non-Hispanic White (NHB) patients with newly diagnosed, advanced-stage endometrial cancer. METHODS: A Markov-based cost-utility model using a third ... Full text Link to item Cite

Preferences of BRCA mutation carriers for attributes of risk-reducing surgical options for breast and ovarian cancer.

Journal article Cancer · November 15, 2025 BACKGROUND: Risk-reducing surgeries are the most effective strategies for cancer prevention in patients with germline pathogenic variants in the BRCA1/BRCA2 genes; these surgeries are associated with early menopause, loss of childbearing potential, and cos ... Full text Link to item Cite

Gynecologic oncology fellowship trends: Supply outpacing demand, geographical maldistribution.

Journal article Gynecol Oncol · November 2025 OBJECTIVE: To examine the trends and geographic distribution of US GO fellowship programs over time and analyze GO specific procedures by regions. METHODS: Using the publicly available data from the NRMP, the number of GO fellowship programs and positions ... Full text Link to item Cite

Survival After Fertility-Preserving Hormonal Therapy vs Hysterectomy for Early-Stage Endometrial Cancer.

Journal article JAMA Oncol · October 1, 2025 IMPORTANCE: As the number of young women with early-stage endometrial cancer is increasing, there is growing interest in use of progesterone-based therapy to allow fertility preservation. OBJECTIVE: To ascertain the long-term survival of premenopausal wome ... Full text Link to item Cite

Trends in uterine cancer incidence and mortality: insights from a natural history model.

Journal article J Natl Cancer Inst · September 1, 2025 BACKGROUND: Uterine cancer incidence and mortality are increasing, with concomitant disparities in outcomes between racial groups. Natural history modeling can evaluate risk factors, predict future trends, and simulate approaches to reducing mortality and ... Full text Link to item Cite

Relationship between abnormal p53 expression and high-risk histology in endometrial cancers and living in proximity to hog concentrated animal feeding operations in North Carolina.

Journal article Gynecol Oncol Rep · August 2025 OBJECTIVE: Prior research demonstrated a 2.27-fold increase in uterine cancer mortality among North Carolinians living near hog concentrated animal feeding operations (CAFOs). Endometrial cancer (EC) accounts for 90% of uterine cancer cases. Mutation and a ... Full text Link to item Cite

Projected Trends in the Incidence and Mortality of Uterine Cancer in the United States.

Journal article Cancer Epidemiol Biomarkers Prev · July 1, 2025 BACKGROUND: To develop a natural history model for uterine cancer calibrated to population-based incidence and mortality data to project future trends in the disease through 2050. METHODS: We developed a state-transition microsimulation model of uterine ca ... Full text Link to item Cite

A pilot study investigating the effect of pembrolizumab on the tumoral immunoprofile of newly diagnosed mullerian cancers.

Journal article Gynecol Oncol Rep · June 2025 OBJECTIVE: This pilot window of opportunity study was conducted to assess feasibility, toxicity, and changes in immune parameters in response to one dose of the PD-1 inhibitor, pembrolizumab, in patients newly diagnosed with mullerian epithelial cancers. M ... Full text Link to item Cite

Quality for All: Clinical Trial Enrollment and End-of-Life Care in Solid and Hematologic Malignancies.

Journal article Cancer Med · May 2025 BACKGROUND: Patients with incurable cancer deserve quality end-of-life (EOL) care. Despite established EOL quality metrics, many patients receive aggressive EOL care with limited goals of care (GOC) documentation. Concurrently, clinical trials are critical ... Full text Link to item Cite

Too Much of a Good Thing? Projecting the Need for Gynecologic Oncologists Over the Next 20 Years

Journal article Obstetrical and Gynecological Survey · May 1, 2025 There are currently 71 gynecologic oncology fellowship programs in the United States, with a rapid increase in the number of programs occurring within the last 5 years. Additionally, accreditation for these fellowships has shifted from the American Board o ... Full text Cite

In Reply.

Journal article Obstet Gynecol · April 1, 2025 Full text Link to item Cite

Ultrasound-based versus immediate biopsy-based management of postmenopausal bleeding in non-Hispanic Black and non-Hispanic White individuals.

Journal article Gynecol Oncol · March 2025 BACKGROUND: Ultrasound-based evaluation of endometrial thickness to rule out endometrial cancer in patients with postmenopausal bleeding (PMB) is not sufficiently validated in the non-Hispanic Black (NHB) population. Differences in ultrasound performance b ... Full text Link to item Cite

Surgical Deescalation Within Gynecologic Oncology.

Journal article JAMA Netw Open · January 2, 2025 IMPORTANCE: The goal of surgical deescalation is to minimize tissue damage, enhance patient outcomes, and reduce the adverse effects often associated with extensive or traditional surgical procedures. This shift toward less invasive techniques has the pote ... Full text Link to item Cite

Screening for Bacterial Vaginosis Prior to Delivery: A Cost-Effectiveness Study.

Journal article Am J Perinatol · January 2025 OBJECTIVE: The objective of this study was to compare the cost and effectiveness of three strategies for screening and/or treating bacterial vaginosis (BV) during pregnancy prior to delivery: (1) the current standard of care was neither test nor treat for ... Full text Link to item Cite

Optimization of Timing for Risk-Reducing Salpingectomy and Oophorectomy.

Journal article Obstet Gynecol · January 1, 2025 ClinicalTrials.gov , NCT04251052. ... Full text Link to item Cite

Transcutaneous Electric Nerve Stimulation for Analgesia During Outpatient Endometrial Biopsy: A Randomized Controlled Trial.

Journal article Obstet Gynecol · January 1, 2025 OBJECTIVE: To evaluate whether transcutaneous electric nerve stimulation (TENS) decreases pain at the time of outpatient endometrial biopsy. METHODS: We conducted a randomized, double-blind trial of active TENS compared with placebo TENS at the time of end ... Full text Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Open Access Link to item Cite

Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Journal article Npj Precision Oncology · December 1, 2024 We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients with longer progre ... Full text Cite

Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities (npj Precision Oncology, (2024), 8, 1, (68), 10.1038/s41698-024-00519-8)

Journal article Npj Precision Oncology · December 1, 2024 Correction to: npj Precision Oncologyhttps://doi.org/10.1038/s41698-024-00519-8, published online 13 March 2024 In the original version of this article, the wrong file was inadvertently supplied for Supplementary Data 15. The original article has been corr ... Full text Cite

Adjuvant therapy and recurrence risk in non-myoinvasive high-grade (stage IC) endometrial cancer: A systematic review and meta-analysis.

Journal article Gynecol Oncol · December 2024 OBJECTIVE: To summarize practice patterns and outcomes among patients with non-myoinvasive high-grade (formerly stage IA, now stage IC) endometrial cancer. METHODS: We conducted a systematic search using MEDLINE, Embase, Cochrane, Web of Science, and Clini ... Full text Link to item Cite

Too much of a good thing? Projecting the need for gynecologic oncologists over the next 20 years.

Journal article Gynecol Oncol · December 2024 OBJECTIVE: To estimate the effect of growth in gynecologic oncology fellowships in the United States on surgical volume for trainees and practicing gynecologic oncologists over the next 20 years. METHODS: Using 2010-2019 age-specific gynecologic cancer inc ... Full text Link to item Cite

Weight-loss therapy in patients with obesity with endometrial intraepithelial neoplasia and uterine cancer.

Journal article Gynecol Oncol · November 2024 OBJECTIVE: Although obesity is an important risk factor for endometrial intraepithelial neoplasia (EIN) and uterine cancer, little is known about the trends in use of weight-loss therapy for patients with obesity with EIN and uterine cancer. We examined th ... Full text Link to item Cite

The doc versus the bot: A pilot study to assess the quality and accuracy of physician and chatbot responses to clinical questions in gynecologic oncology.

Journal article Gynecol Oncol Rep · October 2024 Artificial intelligence (AI) applications to medical care are currently under investigation. We aimed to evaluate and compare the quality and accuracy of physician and chatbot responses to common clinical questions in gynecologic oncology. In this cross-se ... Full text Link to item Cite

Moving the needle: Quality improvement strategies to achieve guideline-concordant care of obstetric patients with severe hypertension.

Journal article Pregnancy Hypertens · September 2024 OBJECTIVES: To improve timely treatment and follow-up of birthing individuals with severe hypertension. STUDY DESIGN: A quality improvement (QI) initiative was implemented at an academic tertiary care center in the United States of America for individuals ... Full text Link to item Cite

Trends in uterine cancer incidence in the United States: The contribution of age, period and cohort effects.

Journal article Gynecol Oncol · August 2024 OBJECTIVE: In the U.S., uterine cancer incidence is rising, with racial and ethnic minorities experiencing the largest increases. We performed age-period-cohort analyses using novel methods to examine the contribution of age at diagnosis (age), year of dia ... Full text Link to item Cite

ACO leakage among gynecologic cancer patients: Incidence, predictors, and impact on annual Medicare expenditure.

Journal article Gynecol Oncol · August 2024 OBJECTIVE: To examine patterns of Accountable Care Organizations (ACO) leakage, the receipt of healthcare by ACO-assigned patients from institutions outside assigned ACO network, among patients with gynecologic cancer. ACO leakage was estimated as rates of ... Full text Link to item Cite

Ensuring safe and equitable discharge: a quality improvement initiative for individuals with hypertensive disorders of pregnancy.

Journal article BMJ Qual Saf · May 17, 2024 OBJECTIVE: To improve timely and equitable access to postpartum blood pressure (BP) monitoring in individuals with hypertensive disorders of pregnancy (HDP). METHODS: A quality improvement initiative was implemented at a large academic medical centre in th ... Full text Open Access Link to item Cite

Role of endometrial sampling to differentiate between advanced endometrial versus ovarian malignancy: retrospective cohort study.

Journal article Int J Gynecol Cancer · April 1, 2024 OBJECTIVE: Distinguishing between advanced stage endometrial and ovarian cancer at diagnosis can be challenging, especially when patients do not present with abnormal uterine bleeding. Given emerging systemic therapies specific for ovarian versus endometri ... Full text Link to item Cite

Randomized Comparison of Electronic Health Record Alert Types in Eliciting Responses about Prognosis in Gynecologic Oncology Patients.

Journal article Appl Clin Inform · March 2024 OBJECTIVES: To compare the ability of different electronic health record alert types to elicit responses from users caring for cancer patients benefiting from goals of care (GOC) conversations. METHODS: A validated question asking if the user would be surp ... Full text Link to item Cite

Development and testing of patient-centered education about hormone replacement therapy for women at high genetic risk of breast and ovarian cancer.

Journal article Gynecol Oncol · February 2024 OBJECTIVE: In this study, we aimed to develop education to assist BRCA mutation carriers in making informed decisions about HRT in the context of risk-reducing surgery, while simultaneously clarifying their treatment-specific values and reducing decisional ... Full text Link to item Cite

An Obstetrician-Gynecologist's Review of Hernias: Risk Factors, Diagnosis, Prevention, and Repair

Journal article Obstetrical and Gynecological Survey · February 1, 2024 Full text Cite

Deep learning-based segmentation of multisite disease in ovarian cancer.

Journal article Eur Radiol Exp · December 7, 2023 PURPOSE: To determine if pelvic/ovarian and omental lesions of ovarian cancer can be reliably segmented on computed tomography (CT) using fully automated deep learning-based methods. METHODS: A deep learning model for the two most common disease sites of h ... Full text Link to item Cite

Cryocompression to Reduce Peripheral Neuropathy in Gynecologic Cancer: A Randomized Controlled Trial.

Journal article Obstet Gynecol · December 1, 2023 OBJECTIVE: To investigate the efficacy of cryocompression therapy to prevent chemotherapy-induced peripheral neuropathy. METHODS: This single-institution, randomized, self-controlled trial of cryocompression enrolled gynecologic cancer patients planned for ... Full text Link to item Cite

Radical hysterectomy case volume and cervical cancer treatment in the era of COVID-19: A multi-site analysis of National Cancer Institute-designated Comprehensive Cancer Centers.

Journal article Gynecol Oncol · December 2023 OBJECTIVE: To compare radical hysterectomy case volume, cancer stage, and biopsy-to-treatment time of invasive cervical cancer diagnosed before and after onset of the COVID-19 pandemic. METHODS: In a multi-institution retrospective cohort study conducted a ... Full text Link to item Cite

Efficacy of cyclin-dependent kinase 4/6 inhibitors in combination with hormonal therapy in patients with recurrent granulosa cell tumor of the ovary: A case series.

Journal article Gynecol Oncol Rep · December 2023 Cyclin-dependent kinase inhibitors are approved in combination with hormonal therapy for treatment of hormone receptor expressing breast cancers. Activity in hormone receptor expressing gynecologic cancers has been postulated. Granulosa cell tumor of the o ... Full text Link to item Cite

Geographic variation in the rate and route of hysterectomy for benign disease in the USA: A retrospective cross-sectional study.

Journal article BJOG · November 2023 OBJECTIVES: To describe population rate of hysterectomy for benign disease in the USA, including geographic variation across states and Hospital Service Areas (HSAs; areas defined by common patient flows to healthcare facilities). DESIGN: Cross-sectional s ... Full text Link to item Cite

Outcomes and Complications for Concurrent Hernia Repair Among Women Undergoing Hysterectomy.

Journal article Obstet Gynecol · November 1, 2023 OBJECTIVE: To assess whether concurrent hernia repair at time of hysterectomy is associated with increased complications. METHODS: In this retrospective cohort study, patients who underwent hysterectomy and hysterectomy with concurrent hernia repair were q ... Full text Link to item Cite

Intraluminal tumor cells and prognostic accuracy of endometrial cancer stage criteria: A multi-institution study.

Journal article Gynecol Oncol · November 2023 OBJECTIVE: Endometrial cancer stage is a strong prognostic factor; however, the current stage classification does not incorporate transtubal spread as determined by intraluminal tumor cells (ILTCs). We examined relationships between ILTCs and survival outc ... Full text Link to item Cite

An obstetrician-gynecologist's review of hernias: risk factors, diagnosis, prevention, and repair.

Journal article Am J Obstet Gynecol · September 2023 Management of obstetrical and gynecologic patients with hernias poses challenges to providers. Risks for hernia development include well-described factors that impair surgical wound healing and increase abdominal pressure. Among the diverse populations car ... Full text Link to item Cite

The Clinical Trial Conundrum for Gynecologic Cancers.

Journal article Obstet Gynecol · September 1, 2023 Full text Link to item Cite

Guidelines for goals of care discussions in patients with gynecologic cancer.

Journal article Gynecol Oncol · July 2023 This article represents a distillation of literature to provide guidance for goals of care discussions with patients who have gynecologic malignancies. As clinicians who provide surgical care, chemotherapy, and targeted therapeutics, gynecologic oncology c ... Full text Link to item Cite

Treatments and outcomes in high-risk gestational trophoblastic neoplasia: A systematic review and meta-analysis.

Journal article BJOG · April 2023 BACKGROUND: High-risk gestational trophoblastic neoplasia (GTN) is rare and treated with diverse approaches. Limited published institutional data has yet to be systematically reviewed. OBJECTIVES: To compile global high-risk GTN (prognostic score ≥7) cohor ... Full text Link to item Cite

A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients.

Journal article J Low Genit Tract Dis · April 1, 2023 OBJECTIVE: Human papillomavirus (HPV)-related squamous intraepithelial lesion (SIL) or malignancy is associated with a significantly increased risk of second-site SIL or malignancy. The primary objective of this study was to determine the feasibility and a ... Full text Link to item Cite

BAP1 Tumor Predisposition Syndrome Presenting as a Recurrent Ovarian Sex Cord-Stromal Tumor.

Journal article Int J Gynecol Pathol · January 1, 2023 The BRCA1-associated protein 1 ( BAP1 ) gene encodes a tumor suppressor that functions as a ubiquitin hydrolase involved in DNA damage repair. BAP1 germline mutations are associated with increased risk of multiple solid malignancies, including mesothelioma ... Full text Link to item Cite

Implementing guidelines for risk-stratified thromboprophylaxis among gynecologic oncology patients: A quality improvement initiative.

Journal article Gynecol Oncol · January 2023 OBJECTIVE(S): Risk-stratified thromboprophylaxis is recommended for oncology patients with a Khorana risk score (KS) ≥ 2 receiving cancer-directed therapy. We describe a quality improvement (QI) initiative designed to increase adherence to thromboprophylax ... Full text Link to item Cite

Cost-effectiveness of management strategies for patients with recurrent ovarian cancer and inoperable malignant bowel obstruction.

Journal article Gynecol Oncol · December 2022 OBJECTIVES: Patients with recurrent platinum-resistant ovarian cancer often present with inoperable malignant bowel obstruction (MBO) from a large burden of abdominal disease. Interventions such as total parenteral nutrition (TPN) and chemotherapy may be u ... Full text Link to item Cite

Understanding the needs and perspectives of ovarian cancer patients when considering PARP inhibitor maintenance therapy: Findings from two online community events.

Journal article Gynecol Oncol Rep · October 2022 OBJECTIVE: The online environment is an ideal setting to understand how many women seek, receive, and understand information about cancer treatment. The purpose of this study was to understand women's needs and information-seeking around Poly ADP ribose po ... Full text Link to item Cite

Improving Risk Assessment for Metastatic Disease in Endometrioid Endometrial Cancer Patients Using Molecular and Clinical Features: An NRG Oncology/Gynecologic Oncology Group Study.

Journal article Cancers (Basel) · August 23, 2022 Objectives: A risk assessment model for metastasis in endometrioid endometrial cancer (EEC) was developed using molecular and clinical features, and prognostic association was examined. Methods: Patients had stage I, IIIC, or IV EEC with tumor-derived RNA- ... Full text Link to item Cite

Development and Validation of a Model for Opioid Prescribing Following Gynecological Surgery.

Journal article JAMA Netw Open · July 1, 2022 IMPORTANCE: Overprescription of opioid medications following surgery is well documented. Current prescribing models have been proposed in narrow patient populations, which limits their generalizability. OBJECTIVE: To develop and validate a model for predic ... Full text Open Access Link to item Cite

Cost-effectiveness of bacteriuria screening before urogynecologic surgery.

Journal article Am J Obstet Gynecol · June 2022 BACKGROUND: Currently, there is controversy over who requires preoperative screening for bacteriuria in the urogynecologic population and whether treating asymptomatic bacteriuria reduces postoperative urinary tract infection rates. OBJECTIVE: To evaluate ... Full text Link to item Cite

Malnutrition as a risk factor for post-operative morbidity in gynecologic cancer: Analysis using a national surgical outcomes database.

Journal article Gynecol Oncol · May 2022 OBJECTIVE: To assess, using a national surgical outcomes database, the association of various malnutrition definitions with post-operative morbidity in three gynecologic malignancies. METHODS: Patients undergoing resection of ovarian, uterine, or cervical ... Full text Link to item Cite

Out-of-network bills among privately insured patients undergoing hysterectomy.

Journal article Am J Obstet Gynecol · April 2022 BACKGROUND: In recent years, the issue of out-of-network billing for privately insured patients has been highlighted as a source of unexpected out-of-pocket charges for patients, even in the setting of an in-network primary surgeon. The Congress recently p ... Full text Link to item Cite

Reducing non-surgical readmissions on a gynecologic oncology service.

Journal article Gynecol Oncol · April 2022 OBJECTIVE: To assess the effects of a quality improvement (QI) initiative designed to reduce non-surgical readmissions on a gynecologic oncology service. METHODS: A two-phase QI initiative was implemented on an inpatient gynecologic oncology service to red ... Full text Link to item Cite

Evaluation of Surgical Morbidity After Hysterectomy During an Obesity Epidemic.

Journal article Obstet Gynecol · April 1, 2022 OBJECTIVE: To assess 30-day outcomes for hysterectomy by body mass index (BMI) classification and estimate trends in 30-day outcomes by BMI over time. METHODS: This is a retrospective cohort study of patients older than age 18 years undergoing hysterectomy ... Full text Link to item Cite

Catastrophic health expenditures, insurance churn, and nonemployment among gynecologic cancer patients in the United States.

Journal article Am J Obstet Gynecol · March 2022 BACKGROUND: In recent years, there has been growing recognition of the financial burden of severe illness, including associations with higher rates of nonemployment, uninsurance, and catastrophic out-of-pocket health spending. Patients with gynecologic can ... Full text Link to item Cite

Distress screening in endometrial cancer leads to disparity in referral to support services.

Journal article Gynecol Oncol · March 2022 OBJECTIVES: Racial disparities in survival from endometrial cancer (EC) are well known. Cancer distress has also been associated with worse clinical outcomes. We characterized the association between race/ethnicity, patient distress reported on the Nationa ... Full text Link to item Cite

Promoting timely goals of care conversations between gynecologic cancer patients at high-risk of death and their providers.

Journal article Gynecol Oncol · February 2022 OBJECTIVE: We designed a multi-faceted intervention to increase the rate of outpatient goals of care (GOC) conversations in women with gynecologic cancers who are at high-risk of death. METHODS AND MATERIALS: A multidisciplinary team developed an education ... Full text Link to item Cite

Standardization of caregiver and nursing perioperative care on gynecologic oncology wards in a resource-limited setting.

Journal article Gynecol Oncol Rep · February 2022 INTRODUCTION: In Kampala, Uganda, there is a strong cultural practice for patients to have designated caregivers for the duration of hospitalization. At the same time, nursing support is limited. This quality improvement project aimed to standardize caregi ... Full text Link to item Cite

A Qualitative Assessment of Patient Experience following Systematic Implementation of Goals of Care Conversations in the Ambulatory Gynecologic Oncology Setting.

Journal article Palliat Med Rep · 2022 OBJECTIVE: Although skilled goals of care (GOC) conversations are known to reduce aggressive futile end-of-life care, they have not been widely implemented nor standardized in the care of gynecologic malignancies. Clinicians express concern regarding patie ... Full text Link to item Cite

Adjuvant treatment and outcomes for patients with stage IIIA grade 1 endometrioid endometrial cancer.

Journal article Int J Gynecol Cancer · December 2021 OBJECTIVE: The role and type of adjuvant therapy for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIA grade 1 endometrioid endometrial adenocarcinoma are controversial. This retrospective cohort study aimed to determine ... Full text Link to item Cite

Patient Preferences for Outcomes Following DCIS Management Strategies: A Discrete Choice Experiment.

Journal article JCO Oncol Pract · November 2021 PURPOSE: Ductal carcinoma in situ (DCIS), a nonobligate precursor of breast cancer, is often aggressively managed with multimodal therapy. However, there is limited research on patients' preferences for trade-offs among treatment-related outcomes such as b ... Full text Link to item Cite

Surveillance for gestational trophoblastic neoplasia following molar pregnancy: a cost-effectiveness analysis.

Journal article Am J Obstet Gynecol · November 2021 BACKGROUND: Historically, published guidelines for care after molar pregnancy recommended monitoring human chorionic gonadotropin levels for the development of gestational trophoblastic neoplasia until normal and then for 6 months after the first normal hu ... Full text Link to item Cite

Neoadjuvant chemotherapy for advanced stage endometrial cancer: A systematic review.

Journal article Gynecol Oncol Rep · November 2021 OBJECTIVE: While primary cytoreductive surgery (PCS) is considered the standard of care for women who present with stage IV endometrial cancer, neoadjuvant chemotherapy (NACT) followed by interval cytoreductive surgery (ICS) has emerged as an alternative t ... Full text Link to item Cite

Histopathology after lidocaine/prilocaine cream administration for vulvar biopsy.

Journal article J Cutan Pathol · October 2021 BACKGROUND: Case series have described disruptive histopathologic changes following lidocaine/prilocaine cream anesthetic for biopsies. METHODS: A study of histopathologic changes was performed following a randomized trial comparing topical lidocaine/prilo ... Full text Link to item Cite

Real-world treatment patterns of maintenance therapy in platinum-sensitive recurrent ovarian cancer.

Journal article Gynecol Oncol · October 2021 OBJECTIVES: The clinical utility of maintenance therapy (MT) for patients with platinum-sensitive recurrent ovarian cancer has been validated in several clinical trials. We assessed "real-world" treatment patterns using an electronic health record (EHR) da ... Full text Link to item Cite

Primary cytoreductive surgery for advanced stage endometrial cancer: a systematic review and meta-analysis.

Journal article Am J Obstet Gynecol · September 2021 OBJECTIVE: Endometrial cancer uncommonly presents at an advanced stage and little prospective evidence exists to guide the management thereof. We aimed to summarize the evidence about primary cytoreductive surgery in the treatment of advanced stage endomet ... Full text Link to item Cite

Associations of Insurance Churn and Catastrophic Health Expenditures With Implementation of the Affordable Care Act Among Nonelderly Patients With Cancer in the United States.

Journal article JAMA Netw Open · September 1, 2021 IMPORTANCE: Health insurance coverage is dynamic in the United States, potentially changing from month to month. The Patient Protection and Affordable Care Act (ACA) aimed to stabilize markets and reduce financial burden, particularly among those with pree ... Full text Link to item Cite

Cost-Effectiveness of Venous Thromboembolism Prophylaxis During Neoadjuvant Chemotherapy for Ovarian Cancer.

Journal article JCO Oncol Pract · August 2021 PURPOSE: Two recent clinical trials have demonstrated that direct oral anticoagulants (DOACs) are effective as venous thromboembolism (VTE) prophylaxis in patients with moderate-to-high risk ambulatory cancer initiating chemotherapy. Patients with advanced ... Full text Link to item Cite

The preferences of women with ovarian cancer for oral versus intravenous recurrence regimens.

Journal article Gynecol Oncol · August 2021 OBJECTIVE: To assess preferences of women with ovarian cancer regarding features of available anti-cancer regimens for platinum-resistant, biomarker-positive disease, with an emphasis on oral PARP inhibitor and standard intravenous (IV) chemotherapy regime ... Full text Link to item Cite

Medicaid Expansion Reduced Uninsured Surgical Hospitalizations And Associated Catastrophic Financial Burden.

Journal article Health Aff (Millwood) · August 2021 An important function of health insurance is protecting enrollees from excessively burdensome charges for unanticipated medical events. Unexpected surgery can be financially catastrophic for uninsured people. By targeting the low-income uninsured populatio ... Full text Link to item Cite

Evaluation of the clinical Index of Stable febrile neutropenia risk stratification system for management of febrile neutropenia in gynecologic oncology patients.

Journal article Gynecol Oncol Rep · August 2021 OBJECTIVE: Scoring systems have been developed to identify low risk patients with febrile neutropenia (FN) who may be candidates for outpatient management. We sought to validate the predictive accuracy of the Clinical Index of Stable Febrile Neutropenia (C ... Full text Link to item Cite

Evaluation of pelvic washing specimens in patients with endometrial cancer: Cytomorphological features, diagnostic agreement, and pathologist experience.

Journal article Cancer Cytopathol · July 2021 BACKGROUND: Pelvic washings for patients with endometrial cancer is recommended but not used for staging. The International System for Reporting Serous Fluid Cytology (TIS) has standardized diagnostic categories, but the criteria remain incomplete. The 3 p ... Full text Link to item Cite

A quality improvement initiative to reduce venous thromboembolism on a gynecologic oncology service.

Journal article Gynecol Oncol · July 2021 OBJECTIVE: To describe and evaluate the effects of implementation of a venous thromboembolism (VTE) prophylaxis quality improvement (QI) initiative on a gynecologic oncology service at a single institution. METHODS: Prior to 2018, no consensus gynecologic ... Full text Link to item Cite

Cost-effectiveness of prenatal screening methods for congenital heart defects in pregnancies conceived by in-vitro fertilization.

Journal article Ultrasound Obstet Gynecol · June 2021 OBJECTIVES: To determine if a policy of universal fetal echocardiography (echo) in pregnancies conceived by in-vitro fertilization (IVF) is cost-effective as a screening strategy for congenital heart defects (CHDs) and to examine the cost-effectiveness of ... Full text Link to item Cite

Chemotherapy discontinuation processes in a gynecologic oncology population.

Journal article Gynecol Oncol · May 2021 OBJECTIVE: We sought to categorize the processes by which gynecologic oncology patients stop chemotherapy and to evaluate associations between these processes and end-of-life outcome metrics. METHODS: A cohort of patients with metastatic or recurrent gynec ... Full text Link to item Cite

Universal screening for Lynch syndrome in uterine cancer patients: A quality improvement initiative.

Journal article Gynecol Oncol · January 2021 OBJECTIVE: To determine the feasibility and effectiveness of a quality improvement initiative (QI) to adopt universal screening for Lynch syndrome in uterine cancer patients at an institution that previously employed age-based screening. METHODS: Prior to ... Full text Link to item Cite

Results and Clinical Utilization of Foundation Medicine Molecular Tumor Profiling in Uterine and Ovarian Cancers.

Journal article Target Oncol · January 2021 BACKGROUND: Recent advances in next-generation sequencing have allowed for an increase in molecular tumor profiling. OBJECTIVE: We sought to assess the actionability and clinical utilization of molecular tumor profiling results obtained via Foundation Medi ... Full text Link to item Cite

The cost-effectiveness of ertapenem for the treatment of chorioamnionitis after cesarean delivery.

Journal article J Matern Fetal Neonatal Med · December 2020 Background: Chorioamnionitis affects 1-4% of pregnancies, and patients who undergo cesarean delivery in the setting of chorioamnionitis have an increased risk of endometritis and surgical site infection (SSI). The standard treatment for chorioamnionitis af ... Full text Link to item Cite

Adherence to Oral Anticancer Therapeutics in the Gynecologic Oncology Population.

Journal article Obstet Gynecol · December 2020 INTRODUCTION: To gain a better understanding of gynecologic oncology patient adherence to oral anticancer agents through both a cross-sectional survey of adherence and qualitative interviews with patients and clinicians regarding their experience with thes ... Full text Link to item Cite

Adjuvant treatment improves overall survival in women with high-intermediate risk early-stage endometrial cancer with lymphovascular space invasion.

Journal article Int J Gynecol Cancer · November 2020 BACKGROUND: Adjuvant therapy in early-stage endometrial cancer has not shown a clear overall survival benefit, and hence, patient selection remains crucial. OBJECTIVE: To determine whether women with high-intermediate risk, early-stage endometrial cancer w ... Full text Link to item Cite

Cost-effectiveness analysis comparing "PARP inhibitors-for-all" to the biomarker-directed use of PARP inhibitor maintenance therapy for newly diagnosed advanced stage ovarian cancer.

Journal article Gynecol Oncol · November 2020 OBJECTIVES: Clinical trials evaluating universal PARP inhibitor (PARPi) frontline maintenance therapy for advanced stage ovarian cancer have reported progression-free survival (PFS) benefit. It is unclear whether PARPi maintenance therapy will universally ... Full text Link to item Cite

Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices.

Journal article Int J Gynecol Cancer · October 2020 OBJECTIVE: Limited information exists regarding risk reduction strategies for women with moderate and low penetrance ovarian cancer susceptibility mutations. We sought to assess current risk reduction practice patterns for carriers of these mutations throu ... Full text Link to item Cite

Are Videos or Text Better for Describing Attributes in Stated-Preference Surveys?

Journal article Patient · August 2020 OBJECTIVE: In stated-preference research, the conventional approach to describing study attributes is through text, often with easy-to-understand graphics. More recently, researchers have begun to present attribute descriptions and content in videos. Some ... Full text Link to item Cite

Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.

Journal article Clin Cancer Res · August 1, 2020 PURPOSE: Uterine-serous-carcinoma (USC) is an aggressive variant of endometrial cancer. On the basis of preliminary results of a multicenter, randomized phase II trial, trastuzumab (T), a humanized-mAb targeting Her2/Neu, in combination with carboplatin/pa ... Full text Link to item Cite

Incidence of venous thromboembolism among patients receiving neoadjuvant chemotherapy for advanced epithelial ovarian cancer.

Journal article Int J Gynecol Cancer · April 2020 OBJECTIVES: Neoadjuvant chemotherapy may be considered for women with epithelial ovarian cancer who have poor performance status or a disease burden not amenable to primary cytoreductive surgery. Overlap exists between indications for neoadjuvant chemother ... Full text Link to item Cite

Intraperitoneal chemotherapy following neoadjuvant chemotherapy and optimal interval tumor reductive surgery for advanced ovarian cancer.

Journal article Gynecol Oncol · March 2020 OBJECTIVES: Intraperitoneal (IP) chemotherapy following neoadjuvant chemotherapy (NACT) and interval tumor reductive surgery (TRS) for advanced ovarian cancer is feasible, however, the impact on disease outcomes remains unclear. We compare outcomes of pati ... Full text Link to item Cite

Adjuvant therapy for early stage, endometrial cancer with lymphovascular space invasion: Is there a role for chemotherapy?

Journal article Gynecologic oncology · March 2020 ObjectivesLymphovascular space invasion (LVSI) is an independent risk factor for recurrence and poor survival in early-stage endometrioid endometrial cancer (EEC), but optimal adjuvant treatment is unknown. We aimed to compare the survival of wome ... Full text Cite

Patient preferences for maintenance PARP inhibitor therapy in ovarian cancer treatment.

Journal article Gynecol Oncol · March 2020 OBJECTIVE: To measure preferences of women with ovarian cancer regarding risks, side effects, costs and benefits afforded by maintenance therapy (MT) with a poly ADP ribose polymerase (PARP) inhibitor. METHODS: A discrete-choice experiment elicited prefere ... Full text Link to item Cite

Lidocaine-Prilocaine Cream Compared With Injected Lidocaine for Vulvar Biopsy: A Randomized Controlled Trial.

Journal article Obstet Gynecol · February 2020 OBJECTIVE: To compare pain control during vulvar biopsy after either application of 5% lidocaine-prilocaine cream or injection of 1% lidocaine. METHODS: In a single-site randomized trial, patients who needed vulvar biopsy on a non-hair-bearing surface were ... Full text Link to item Cite

Off-study utilization of experimental therapies: Analysis of GOG249-eligible cohorts using real world data.

Journal article Gynecol Oncol · January 2020 OBJECTIVE: Adjuvant management of women with high-intermediate- and high-risk early-stage endometrial cancer remains controversial. Recently published results of GOG 249 revealed that vaginal brachytherapy plus chemotherapy (VBT + CT) was not superior to w ... Full text Link to item Cite

Cell-free DNA for Down syndrome screening in obese women: Is it a cost-effective strategy?

Journal article Prenat Diagn · January 2020 OBJECTIVE: Determine cost differences between cell-free DNA (cfDNA) and serum integrated screening (INT) in obese women given the limitations of aneuploidy screening in this population. METHODS: Using a decision-analytic model, we estimated the cost-effect ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Patient preferences for attributes of primary surgical debulking versus neoadjuvant chemotherapy for treatment of newly diagnosed ovarian cancer.

Journal article Cancer · December 15, 2019 BACKGROUND: Randomized trials have reported conflicting findings on survival for advanced-stage ovarian cancer treated with primary debulking surgery (PDS) versus neoadjuvant chemotherapy with interval debulking; surgical complications and mortality are hi ... Full text Link to item Cite

Simulated Costs of the ASCO Patient-Centered Oncology Payment Model in Medicare Beneficiaries With Newly Diagnosed Advanced Ovarian Cancer.

Journal article J Oncol Pract · December 2019 PURPOSE: Efforts to curb the rising costs of cancer care while improving quality include alternative payment models (APMs), which offer incentives to reduce avoidable spending and provide high-quality and cost-efficient care. The impact of proposed APMs ha ... Full text Link to item Cite

Place of death by region and urbanization among gynecologic cancer patients: 2006-2016.

Journal article Gynecol Oncol · October 2019 OBJECTIVE: To evaluate associations between US region of residence and urbanization and the place of death among women with gynecologic malignancies in the United States. METHODS: A retrospective cross-sectional study was performed using publicly available ... Full text Link to item Cite

Gender variation in Medicare utilization and payments in gynecologic oncology.

Journal article Gynecol Oncol · September 2019 OBJECTIVES: The Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File (POSPUF) and Medicare Physician and Other Supplier National Provider Identifier (POS NPI) Aggregate Report are publicly available files from the Ce ... Full text Link to item Cite

Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.

Journal article Gynecol Oncol · July 2019 OBJECTIVE: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance to endocrine therapy, especially ... Full text Link to item Cite

Phase II trial of nintedanib in patients with bevacizumab-resistant recurrent epithelial ovarian, tubal, and peritoneal cancer.

Journal article Gynecol Oncol · June 2019 BACKGROUND: Bevacizumab provides benefit in epithelial ovarian cancer (EOC), yet resistance to bevacizumab often occurs. We determined if nintedanib, a tyrosine kinase inhibitor of VEGF, FGF, and PDGF receptors has antitumor activity in bevacizumab-resista ... Full text Link to item Cite

Reduction in opioid use and postoperative pain scores after elective laparotomy with implementation of enhanced recovery after surgery protocol on a gynecologic oncology service.

Journal article Int J Gynecol Cancer · June 2019 OBJECTIVE: Enhanced Recovery After Surgery (ERAS) protocols are designed to mitigate the physiologic stress response created by surgery, to decrease the time to resumption of daily activities, and to improve overall recovery. This study aims to investigate ... Full text Link to item Cite

Associations between lymphovascular space invasion, nodal recurrence, and survival in patients with surgical stage I endometrioid endometrial adenocarcinoma.

Journal article World J Surg Oncol · May 10, 2019 OBJECTIVE: To investigate the predictive value of lymphovascular space invasion (LVSI) for nodal recurrence and overall survival (OS) in patients with stage I endometrioid endometrial cancer (EC) following surgical staging that included adequate lymph node ... Full text Link to item Cite

Cost-effectiveness of hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking of epithelial ovarian cancer following neoadjuvant chemotherapy.

Journal article Gynecol Oncol · May 2019 OBJECTIVES: A recent randomized controlled trial demonstrated an overall survival benefit to the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to neoadjuvant chemotherapy (NACT) for stage III epithelial ovarian cancer (EOC). The objective o ... Full text Link to item Cite

Impact of a documentation intervention on health-assessment metrics on an inpatient gynecologic oncology service.

Journal article Gynecol Oncol · May 2019 OBJECTIVE: Accurate documentation is critical for patient care and hospital reimbursement. We sought to improve the accuracy of severity of illness (SOI) and risk of mortality (ROM) scores through implementation of documentation initiatives. METHODS: We pe ... Full text Link to item Cite

A pilot study of lower extremity lymphedema, lower extremity function, and quality of life in women after minimally invasive endometrial cancer staging surgery.

Journal article Gynecol Oncol · May 2019 OBJECTIVE: The primary aim of this study was to pilot the use of an objective measurement technique to prospectively evaluate the incidence of lower extremity lymphedema (LEL) after minimally invasive staging surgery for endometrial cancer. Secondary objec ... Full text Link to item Cite

Radiation Records in the National Cancer Database: Variations in Coding and/or Practice Can Significantly Alter Survival Results.

Journal article JCO Clin Cancer Inform · May 2019 PURPOSE: The aim of the current work was to quantify internally inconsistent and anomalous radiation therapy (RT) data in the National Cancer Database (NCDB) and determine their association with overall survival (OS) using node-positive uterine cancer as a ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

U.S. Food and Drug Administration-Approved Poly (ADP-Ribose) Polymerase Inhibitor Maintenance Therapy for Recurrent Ovarian Cancer: A Cost-Effectiveness Analysis.

Journal article Obstet Gynecol · April 2019 OBJECTIVE: We sought to determine whether use of a poly (ADP-ribose) polymerase inhibitor is cost effective for maintenance treatment of platinum-sensitive recurrent ovarian cancer. METHODS: A decision analysis model compared four maintenance strategies: 1 ... Full text Link to item Cite

Induction of Labor versus Scheduled Cesarean in Morbidly Obese Women: A Cost-Effectiveness Analysis.

Journal article Am J Perinatol · March 2019 OBJECTIVE: To assess the costs, complication rates, and harm-benefit tradeoffs of induction of labor (IOL) compared to scheduled cesarean delivery (CD) in women with class III obesity. STUDY DESIGN: We conducted a cost analysis of IOL versus scheduled CD i ... Full text Link to item Cite

Targeted composite value-based endpoints in platinum-sensitive recurrent ovarian cancer.

Journal article Gynecol Oncol · March 2019 OBJECTIVES: FDA-approved treatments for platinum-sensitive recurrent ovarian cancer (PSROC) include bevacizumab and PARP inhibitors (PARPi); clinical decisions regarding therapy must be made prior to initiating chemotherapy. Using the American Society of C ... Full text Link to item Cite

Changes in insurance coverage for cancer patients receiving brachytherapy before and after enactment of the Affordable Care Act.

Journal article Brachytherapy · 2019 PURPOSE: The Patient Protection and Affordable Care Act called for expansion of Medicaid in 2014. As some states elected to expand Medicaid and others did not, the goal of this study was to determine the effect of Medicaid expansion on the insurance status ... Full text Link to item Cite

Preferences of women with epithelial ovarian cancer for aspects of genetic testing.

Journal article Gynecol Oncol Res Pract · 2019 BACKGROUND: Although genetic testing is recommended for women with epithelial ovarian cancer (EOC), little is known about patient preferences for various testing options. We measured relative preferences for attributes of testing in women with EOC referred ... Full text Link to item Cite

Hysterectomy with sentinel lymph node biopsy in the setting of pre-operative diagnosis of endometrial intraepithelial neoplasia: A cost-effectiveness analysis.

Journal article Gynecol Oncol · December 2018 OBJECTIVES: Sentinel lymph node biopsy (SLNB) may be considered in the setting of a pre-operative diagnosis of endometrial intraepithelial neoplasia (EIN) due to high rates of concurrent invasive cancer. The aim of this study is to compare the cost-effecti ... Full text Link to item Cite

Gender trends in gynecologic oncology authorship: Implications for the critical evaluation of gender distribution in academic rank and leadership positions.

Journal article Gynecol Oncol · December 2018 OBJECTIVE: To investigate trends in the representation of women as first, last, or co-authors in Gynecologic Oncology (GO) publications over the past 15 years. To compare rates of female authorship in GO versus general Obstetrics and Gynecology (Ob/Gyn) an ... Full text Link to item Cite

Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu.

Journal article J Clin Oncol · July 10, 2018 Purpose Uterine serous carcinoma is a rare, aggressive variant of endometrial cancer. Trastuzumab is a humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (HER2)/neu, a receptor overexpressed in 30% of uterine serous carcino ... Full text Link to item Cite

Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-grade Endometrial Cancer.

Journal article Int J Gynecol Pathol · May 2018 To determine whether the processing of additional adipose tissue collected during lymph node (LN) dissection results in the identification of additional LNs during endometrial cancer (EC) staging and to determine if the division of LNs into nodal basin-spe ... Full text Link to item Cite

Estimating potential for savings for low risk endometrial cancer using the Endometrial Cancer Alternative Payment Model (ECAP): A companion paper to the Society of Gynecologic Oncology Report on the Endometrial Cancer Alternative Payment Model.

Journal article Gynecol Oncol · May 2018 OBJECTIVE: To design an endometrial cancer (EC) alternative payment (ECAP) model focused on surgical management of EC, as well as identify drivers of cost in order to develop opportunities for cost-savings while maintaining quality of care. METHODS: Nation ... Full text Link to item Cite

Society of Gynecologic Oncology Future of Physician Payment Reform Task Force report: The Endometrial Cancer Alternative Payment Model (ECAP).

Journal article Gynecol Oncol · May 2018 Health care in the United States is in the midst of a significant transformation from a "fee for service" to a "fee for value" based model. The Medicare Access and CHIP Reauthorization Act of 2015 has only accelerated this transition. Anticipating these re ... Full text Link to item Cite

Estimating the number of potential family members eligible for BRCA1 and BRCA2 mutation testing in a "Traceback" approach.

Journal article Genet Epidemiol · February 2018 U.S. guidelines recommend BRCA1/2 mutation testing for women diagnosed with high-grade ovarian cancer (HGOC) to increase recognition of carriers, but most remain unidentified and at risk. Accordingly, an approach termed "Traceback" has been proposed in whi ... Full text Link to item Cite

Estimating Cost-effectiveness of a Multimodal Ovarian Cancer Screening Program in the United States: Secondary Analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Journal article JAMA Oncol · February 1, 2018 IMPORTANCE: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is the largest randomized clinical trial to evaluate screening's impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum cancer an ... Full text Link to item Cite

Predicting 6- and 12-Month Risk of Mortality in Patients With Platinum-Resistant Advanced-Stage Ovarian Cancer: Prognostic Model to Guide Palliative Care Referrals.

Journal article Int J Gynecol Cancer · February 2018 OBJECTIVE: Predictive models are increasingly being used in clinical practice. The aim of the study was to develop a predictive model to identify patients with platinum-resistant ovarian cancer with a prognosis of less than 6 to 12 months who may benefit f ... Full text Link to item Cite

Trends in Insurance Status Among Patients Diagnosed With Cancer Before and After Implementation of the Affordable Care Act.

Journal article J Oncol Pract · February 2018 PURPOSE: The Affordable Care Act (ACA) aimed to increase insurance coverage through key provisions such as expansion of Medicaid eligibility and enforcement of an individual mandate. The objective of this study is to examine the impact of the ACA on insura ... Full text Link to item Cite

Geriatric Assessment: Precision Medicine for Older Adults With Cancer

Journal article Journal of Oncology Practice · February 2018 Full text Cite

The use of patient-reported outcome tools in Gynecologic Oncology research, clinical practice, and value-based care.

Journal article Gynecol Oncol · January 2018 Patient-reported outcomes (PRO) are defined as a report of a patient's symptoms, function and general well-being that comes directly from the patient, without interpretation of the response by a medical provider. As greater emphasis is placed on high-quali ... Full text Link to item Cite

Is it reasonable to administer pegfilgrastim on day 1 of a myelosuppressive chemotherapy regimen? A cost-utility analysis.

Journal article Cancer Treat Res Commun · 2018 BACKGROUND: There is recent evidence supporting the safety and efficacy of same-day dosing of pegfilgrastim in patients undergoing chemotherapy. OBJECTIVE: To determine the cost-effectiveness of pegfilgrastim on day 1 (D1) versus day 2 (D2) for primary pre ... Full text Link to item Cite

High-volume providers and brachytherapy practice: A Medicare provider utilization and payment analysis.

Journal article Brachytherapy · 2018 PURPOSE: Brachytherapy is an important component of the treatment of gynecologic and prostate cancers, with data supporting its impact on clinical outcomes. Prior data have suggested that brachytherapy tends to be focused at high-volume centers. Medicare r ... Full text Link to item Cite

ASCO Value Framework Highlights the Relative Value of Treatment Options in Ovarian Cancer.

Journal article J Oncol Pract · December 2017 PURPOSE: The ASCO value framework allows physicians and patients to compare the relative value of novel treatments. Our aim was to assess the value of three frontline ovarian cancer therapies by using this framework. METHODS: From phase III, randomized con ... Full text Link to item Cite

Use of a novel sentinel lymph node mapping algorithm reduces the need for pelvic lymphadenectomy in low-grade endometrial cancer.

Journal article Gynecol Oncol · December 2017 OBJECTIVES: To evaluate the capability of a novel sentinel lymph node (SLN) mapping algorithm to reduce the need for pelvic lymphadenectomy (PLND) in patients with low-grade (G1-2) endometrial cancer (LGEC). METHODS: Patients with LGEC underwent evaluation ... Full text Link to item Cite

Data-Derived Treatment Duration Goal for Cervical Cancer: Should 8 Weeks Remain the Target in the Era of Concurrent Chemoradiation?

Journal article JCO Clin Cancer Inform · November 2017 PURPOSE: Prior studies have demonstrated the importance of treatment duration (TD) in radiation therapy (RT) for cervical cancer, with an 8-week goal based primarily on RT alone. This study uses a contemporary cohort to estimate the time point by which com ... Full text Link to item Cite

Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients.

Journal article Cancer · October 15, 2017 BACKGROUND: The objective of this study was to identify molecular alterations associated with disease outcomes for white and black patients with endometrioid endometrial cancer (EEC). METHODS: EEC samples from black (n = 17) and white patients (n = 13) wer ... Full text Link to item Cite

Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer.

Journal article Ann Surg Oncol · October 2017 BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with ... Full text Link to item Cite

Quality of life is significantly associated with survival in women with advanced epithelial ovarian cancer: An ancillary data analysis of the NRG Oncology/Gynecologic Oncology Group (GOG-0218) study.

Journal article Gynecol Oncol · October 2017 OBJECTIVE: Evaluate association between baseline quality of life (QOL) and changes in QOL measured by FACT-O TOI with progression-free disease (PFS) and overall survival (OS) in advanced epithelial ovarian cancer (EOC). METHODS: Patients enrolled in GOG-02 ... Full text Link to item Cite

Insurance coverage among women diagnosed with a gynecologic malignancy before and after implementation of the Affordable Care Act.

Journal article Gynecol Oncol · September 2017 OBJECTIVE: The Patient Protection and Affordable Care Act (ACA) included provisions to expand insurance coverage by expanding Medicaid eligibility, providing subsidies of private coverage and enforcing an individual mandate. The objective of this study is ... Full text Link to item Cite

Cost-effectiveness of opportunistic salpingectomy for ovarian cancer prevention.

Journal article Gynecol Oncol · August 2017 OBJECTIVES: Data suggesting a link between the fallopian tube and ovarian cancer have led to an increase in rates of salpingectomy at the time of pelvic surgery, a practice known as opportunistic salpingectomy (OS). However, the potential benefits, risks a ... Full text Link to item Cite

Mortality reduction and cost-effectiveness of performing hysterectomy at the time of risk-reducing salpingo-oophorectomy for prophylaxis against serous/serous-like uterine cancers in BRCA1 mutation carriers.

Journal article Gynecol Oncol · June 2017 OBJECTIVE: To estimate the survival benefit and cost-effectiveness of performing hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) for BRCA1 mutation carriers. METHODS: Based on a recent prospective cohort study indicating an elevated incidenc ... Full text Link to item Cite

Primary Versus Preoperative Radiation for Locally Advanced Vulvar Cancer.

Journal article Int J Gynecol Cancer · May 2017 OBJECTIVES: The objective of this study was to evaluate patterns of care and the survival impact of primary radiation and preoperative radiation therapy with surgery in women with locally advanced vulvar cancer using a large national cohort. METHODS AND MA ... Full text Link to item Cite

Impact of Chemotherapy and Radiotherapy on Management of Early Stage Clear Cell and Papillary Serous Carcinoma of the Uterus.

Journal article Int J Gynecol Cancer · May 2017 OBJECTIVE: The aim of the study was to assess interaction of lymph node dissection (LND), adjuvant chemotherapy (CT), and radiotherapy (RT) in stage I uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCC). METHODS/MATERIALS: The ... Full text Link to item Cite

Prior breast cancer and tamoxifen exposure does not influence outcomes in women with uterine papillary serous carcinoma.

Journal article Gynecol Oncol · March 2017 OBJECTIVES: To evaluate progression-free survival (PFS) and overall survival (OS) outcomes in women diagnosed with uterine papillary serous carcinoma (UPSC) who have had (UPSCBR+) or have not had (UPSCBR-) an antecedent history of breast cancer and to corr ... Full text Link to item Cite

Cost Comparison of Genetic Testing Strategies in Women With Epithelial Ovarian Cancer.

Journal article J Oncol Pract · February 2017 PURPOSE: The advent of multigene panels has increased genetic testing options for women with epithelial ovarian cancer (EOC). We designed a decision model to compare costs and probabilities of identifying a deleterious mutation or variant of uncertain sign ... Full text Link to item Cite

Are different methotrexate regimens as first line therapy for low risk gestational trophoblastic neoplasia more cost effective than the dactinomycin regimen used in GOG 0174?

Journal article Gynecol Oncol · January 2017 OBJECTIVES: Gynecologic Oncology Group (GOG) 0174 compared weekly intramuscular methotrexate (MTX) with biweekly pulsed intravenous dactinomycin (Act-D) as single-agent chemotherapy for low-risk gestational trophoblastic neoplasia (GTN). Act-D had a higher ... Full text Link to item Cite

Disparities in the surgical staging of high-grade endometrial cancer in the United States.

Journal article Gynecol Oncol Res Pract · 2017 BACKGROUND: The National Comprehensive Cancer Network (NCCN) and the Society of Gynecologic Oncology (SGO) recommend lymph node sampling (LNS) as a key component in the surgical staging of high-grade endometrial cancer. Our goal was to examine surgical sta ... Full text Open Access Link to item Cite

Promoting Same-Day Discharge for Gynecologic Oncology Patients in Minimally Invasive Hysterectomy.

Journal article J Minim Invasive Gynecol · 2017 STUDY OBJECTIVE: Despite clear data demonstrating feasibility, safety, and cost-effectiveness of same-day discharge after minimally invasive hysterectomy, a paucity of data suggests ways to increase same-day discharge rates. Our objectives were to promote ... Full text Link to item Cite

Multidisciplinary approach to manage antenatally suspected placenta percreta: updated algorithm and patient outcomes.

Journal article Gynecol Oncol Res Pract · 2017 BACKGROUND: Due to the significant morbidity and mortality associated with placenta percreta, alternative management options are needed. Beginning in 2005, our institution implemented a multidisciplinary strategy to patients with suspected placenta percret ... Full text Open Access Link to item Cite

Definitive Chemoradiotherapy for Vulvar Cancer.

Journal article Int J Gynecol Cancer · November 2016 OBJECTIVES: This study aimed to evaluate clinical outcomes after chemoradiation (CRT) for the definitive (nonsurgical) treatment of vulvar cancer. MATERIALS AND METHODS: Women with vulvar cancer treated with definitive CRT at a single academic institution ... Full text Link to item Cite

Levonorgestrel Intrauterine Device as an Endometrial Cancer Prevention Strategy in Obese Women: A Cost-Effectiveness Analysis.

Journal article Obstet Gynecol · October 2016 OBJECTIVE: To estimate the cost-effectiveness of the levonorgestrel intrauterine device (IUD) as an endometrial cancer prevention strategy in obese women. METHODS: A modified Markov model was used to compare IUD placement at age 50 with usual care among wo ... Full text Link to item Cite

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.

Journal article J Natl Compr Canc Netw · September 2016 This selection from the NCCN Guidelines for Ovarian Cancer focuses on the less common ovarian histopathologies (LCOHs), because new algorithms were added for LCOHs and current algorithms were revised for the 2016 update. The new LCOHs algorithms include cl ... Full text Link to item Cite

Tumor grade and chemotherapy response in endometrioid endometrial cancer.

Journal article Gynecol Oncol Rep · August 2016 The objective of this study is to evaluate the association between tumor grade and response to chemotherapy in patients with endometrioid endometrial adenocarcinoma. Patients with advanced or recurrent endometrioid endometrial adenocarcinoma of known tumor ... Full text Link to item Cite

Performance of sentinel lymph node biopsy in high-risk endometrial cancer.

Journal article Gynecol Oncol Rep · August 2016 OBJECTIVE: To determine the rate and performance of sentinel lymph node (SLN) mapping among women with high-risk endometrial cancers. METHODS: Patients diagnosed between 2012 and 2015 with uterine cancer of grade 3 endometrioid, clear cell, serous or carci ... Full text Link to item Cite

A personalized paradigm in the treatment of platinum-resistant ovarian cancer - A cost utility analysis of genomic-based versus cytotoxic therapy.

Journal article Gynecol Oncol · July 2016 OBJECTIVE: To assess the cost-effectiveness of a strategy employing genomic-based tumor testing to guide therapy for platinum-resistant ovarian cancer. METHODS: A decision model was created to compare standard of care (SOC) cytotoxic chemotherapy to a geno ... Full text Link to item Cite

Does Routine Posttreatment PET/CT Add Value to the Care of Women With Locally Advanced Cervical Cancer?

Journal article Int J Gynecol Cancer · June 2016 OBJECTIVES: The aim of this study was to determine the necessary reduction in recurrence rate that would make postchemoradiation positron emission tomography (PET)/computed tomography (CT) to direct completion hysterectomy for locally advanced cervical can ... Full text Link to item Cite

Is Intraperitoneal Chemotherapy Dead?

Journal article Obstet Gynecol · June 2016 Full text Link to item Cite

Sensitivity of ovarian cancer cells to acetaminophen reveals biological pathways that affect patient survival.

Journal article Mol Clin Oncol · March 2016 Experimental and epidemiological data support the potential activity of acetaminophen against ovarian cancer (OVCA). In this study, we sought to confirm the activity of acetaminophen in OVCA cell lines and to investigate the molecular basis of response. A ... Full text Link to item Cite

Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis.

Journal article Gynecol Oncol · January 2016 OBJECTIVE: To evaluate the association between body mass index (BMI) and mortality in women with endometrial cancer. METHODS: A systematic review was performed utilizing a Medline search with Mesh keywords 'endometrial neoplasms' and ('body mass index' or ... Full text Link to item Cite

Impact of postoperative nausea and vomiting prophylaxis with dexamethasone on the risk of recurrence of endometrial cancer.

Journal article Curr Med Res Opin · 2016 OBJECTIVE: To assess whether antiemetic doses of dexamethasone are associated with an increased risk of cancer recurrence in women who underwent surgery for endometrial cancer. RESEARCH DESIGN AND METHODS: This is a retrospective study at an academic unive ... Full text Link to item Cite

Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis.

Journal article Gynecol Oncol Res Pract · 2016 BACKGROUND: Chemotherapy plays a role in the treatment of endometrioid endometrial cancer (EEC); however, tumor grade may affect response. Our objective was to evaluate associations between tumor grade and in vitro chemoresponse. METHODS: We conducted an a ... Full text Open Access Link to item Cite

Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: An NRG oncology/gynecologic oncology group study.

Journal article Gynecol Oncol · December 2015 OBJECTIVES: Changes in cognitive function have been identified in and reported by many cancer survivors. These changes have the potential to impact patient quality of life and functional ability. This prospective longitudinal study was designed to quantify ... Full text Link to item Cite

A multi-institutional study of outcomes in stage I-III uterine carcinosarcoma.

Journal article Gynecol Oncol · November 2015 OBJECTIVE: To evaluate the use of adjuvant therapy after primary surgery for stage I-III uterine carcinosarcoma (CS). METHODS: A multi-institutional retrospective study of women with stage I-III CS was conducted. Analyses were stratified by stage (I/II and ... Full text Link to item Cite

Benefits and Harms of Breast Cancer Screening: A Systematic Review.

Journal article JAMA · October 20, 2015 IMPORTANCE: Patients need to consider both benefits and harms of breast cancer screening. OBJECTIVE: To systematically synthesize available evidence on the association of mammographic screening and clinical breast examination (CBE) at different ages and in ... Full text Link to item Cite

Improving NCCN guideline-adherent care for ovarian cancer: Value of an intervention.

Journal article Gynecol Oncol · September 2015 OBJECTIVE: To estimate the potential cost-effectiveness of an intervention to improve adherence to National Comprehensive Cancer Network (NCCN) guideline-based care for ovarian cancer. METHODS: A modified Markov model with a 5-year time horizon estimated t ... Full text Link to item Cite

Consensus in controversy: The modified Delphi method applied to Gynecologic Oncology practice.

Journal article Gynecol Oncol · September 2015 OBJECTIVES: To determine the degree of consensus regarding the probabilities of outcomes associated with IP/IV and IV chemotherapy. METHODS: A survey was administered to an expert panel using the Delphi method. Ten ovarian cancer experts were asked to esti ... Full text Link to item Cite

Bariatric surgery as a means to decrease mortality in women with type I endometrial cancer - An intriguing option in a population at risk for dying of complications of metabolic syndrome.

Journal article Gynecol Oncol · September 2015 OBJECTIVE: To estimate the cost-effectiveness and utility of a strategy of offering weight loss surgery (WLS) to women with low risk stage I endometrial cancer (EC) and BMI≥40kg/m(2). METHODS: A modified Markov state transition model was designed to compar ... Full text Link to item Cite

Lumbee Native American ancestry and the incidence of aggressive histologic subtypes of endometrial cancer.

Journal article Gynecol Oncol Rep · August 2015 OBJECTIVE: The Lumbee Indian tribe is the largest Native American tribe in North Carolina, with about 55,000 enrolled members who mostly reside in southeastern counties. We evaluated whether Lumbee heritage is associated with high-risk histologic subtypes ... Full text Link to item Cite

Patient and physician factors associated with participation in cervical and uterine cancer trials: an NRG/GOG247 study.

Journal article Gynecol Oncol · July 2015 PURPOSE: The aim of this study was to identify patient and physician factors related to enrollment onto Gynecologic Oncology Group (GOG) trials. METHODS: Prospective study of women with primary or recurrent cancer of the uterus or cervix treated at a GOG i ... Full text Link to item Cite

Selective cardiac surveillance in patients with gynecologic cancer undergoing treatment with pegylated liposomal doxorubicin (PLD).

Journal article Gynecol Oncol · June 2015 OBJECTIVE: The study objective was to examine the safety and cost savings of selective cardiac surveillance (CS) during treatment with pegylated liposomal doxorubicin (PLD). METHODS: A retrospective, dual institution study of women receiving PLD for the tr ... Full text Link to item Cite

Patient-reported outcomes as end points and outcome indicators in solid tumours.

Journal article Nat Rev Clin Oncol · June 2015 Patient-reported outcome (PRO) measures, such as quality of life, have been associated with relevant clinical end points and are prognostic for survival outcomes in a variety of solid cancers in adults. In the past few years, PROs have garnered a greater i ... Full text Link to item Cite

Costs, effectiveness, and workload impact of management strategies for women with an adnexal mass

Journal article Obstetrical and Gynecological Survey · April 22, 2015 Full text Cite

A review of relative dose intensity and survival in patients with metastatic solid tumors.

Journal article Crit Rev Oncol Hematol · March 2015 Studies have shown that in the curative setting patients with cancer receiving chemotherapy at higher relative dose intensity (RDI) had better clinical outcomes than those receiving treatment at lower RDI. However, the impact of RDI in advanced/metastatic ... Full text Link to item Cite

A cost-utility analysis of NRG Oncology/Gynecologic Oncology Group Protocol 218: incorporating prospectively collected quality-of-life scores in an economic model of treatment of ovarian cancer.

Journal article Gynecol Oncol · February 2015 OBJECTIVE: To estimate quality-of-life (QOL)-adjusted cost-utility with addition of bevacizumab (B) to intravenous paclitaxel/carboplatin (PC) for primary treatment of advanced-stage epithelial ovarian cancer. METHODS: A modified Markov state transition mo ... Full text Link to item Cite

Lymphatic mapping and sentinel lymph node dissection compared to complete lymphadenectomy in the management of early-stage vulvar cancer: A cost-utility analysis.

Journal article Gynecol Oncol · February 2015 OBJECTIVE: Sentinel lymph node biopsy (SLNB) is an acceptable method of evaluating groin lymph nodes in women with vulvar cancer. The purpose of this study is to assess the cost and effectiveness of SLNB compared to universal inguinofemoral lymphadenectomy ... Full text Link to item Cite

Bevacizumab in recurrent, persistent, or advanced stage carcinoma of the cervix: is it cost-effective?

Journal article Gynecol Oncol · January 2015 OBJECTIVE: Evaluate the cost-effectiveness of incorporating bevacizumab into the treatment regimen for recurrent, persistent, or advanced stage carcinoma of the cervix following publication of a recent phase III trial that demonstrated an overall survival ... Full text Link to item Cite

Costs, effectiveness, and workload impact of management strategies for women with an adnexal mass.

Journal article J Natl Cancer Inst · January 2015 BACKGROUND: We compared the estimated clinical outcomes, costs, and physician workload resulting from available strategies for deciding which women with an adnexal mass should be referred to a gynecologic oncologist. METHODS: We used a microsimulation mode ... Full text Link to item Cite

Postoperative Pain Scores and Narcotic Use in Robotic-assisted Versus Laparoscopic Hysterectomy for Endometrial Cancer Staging.

Journal article J Minim Invasive Gynecol · 2015 STUDY OBJECTIVE: To retrospectively evaluate perioperative pain and analgesic and antiemetic use in patients who underwent surgical staging for endometrial cancer using traditional versus robotic-assisted laparoscopy. DESIGN: We identified women in a singl ... Full text Link to item Cite

Patient preferences in advanced or recurrent ovarian cancer.

Journal article Cancer · December 1, 2014 BACKGROUND: The objective of this study was to elucidate relative preferences of women with ovarian cancer for symptoms, treatment-related side effects, and progression-free survival (PFS) relevant to choosing a treatment regimen. METHODS: Women with advan ... Full text Link to item Cite

A modified bipedicle VRAM flap for simultaneous reconstruction of a perineal and posterior vaginal defect

Journal article Gynakologe · October 14, 2014 The management of locally advanced pelvic tumors regularly requires radical surgical resection. The resection results in significant intrinsic and extrinsic pelvic defects. The advent of composite flaps has revolutionized vaginal and perineal reconstructio ... Full text Cite

Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients.

Journal article Gynecol Oncol · May 2014 OBJECTIVE: The aim of this study is to determine whether a minimally invasive approach to hysterectomy is associated with an increased rate of lymph vascular space invasion (LVSI) and/or malignant pelvic peritoneal cytology in endometrial cancer. METHODS: ... Full text Link to item Cite

The complex triad of obesity, diabetes and race in Type I and II endometrial cancers: prevalence and prognostic significance.

Journal article Gynecol Oncol · April 2014 BACKGROUND: We examined the distribution of obesity, diabetes, and race in Type I and Type II endometrial cancers (EC) and their associations with clinical outcomes. METHODS: A multi-institutional retrospective analysis of Type I and II EC cases from Janua ... Full text Link to item Cite

Cost of care using prophylactic negative pressure wound vacuum on closed laparotomy incisions.

Journal article Gynecol Oncol · March 2014 OBJECTIVE: We wished to determine the reduction in the rate of wound complications that would render the use of prophylactic negative pressure wound vacuum therapy (NPWT) cost saving compared to routine incision care (RC) following laparotomy for gynecolog ... Full text Link to item Cite

Metformin is associated with improved survival in endometrial cancer.

Journal article Gynecol Oncol · February 2014 OBJECTIVE: Preclinical evidence suggests that metformin exhibits anti-tumorigenic effects in endometrial cancer. We sought to investigate the association of metformin on endometrial cancer outcomes. METHODS: A multi-institutional IRB-approved retrospective ... Full text Link to item Cite

Can we maximize both value and quality in gynecologic cancer care? A work in progress.

Journal article Am Soc Clin Oncol Educ Book · 2014 Value is defined as desirable health outcomes achieved per monetary unit spent. Comparative effectiveness research and cost-effectiveness research are methods that have been developed to quantify effectiveness and value to inform management decisions. In t ... Full text Link to item Cite

Does adjuvant chemotherapy improve survival for women with early-stage uterine leiomyosarcoma?

Journal article Gynecol Oncol · December 2013 OBJECTIVES: To examine whether adjuvant therapy after primary surgery for treatment of early-stage uterine leiomyosarcoma (LMS) improves recurrence and survival rates. METHODS: A multisite, retrospective study of women diagnosed with stage I-II high grade ... Full text Link to item Cite

Oral contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis.

Journal article J Clin Oncol · November 20, 2013 PURPOSE: To estimate the risks of ovarian cancer and breast cancer associated with oral contraceptive (OC) use among women at elevated risk owing to mutations in BRCA1/2 or a strong family history. METHODS: We searched PubMed, Embase, the Cochrane Database ... Full text Link to item Cite

Oral contraceptive use and risk of breast, cervical, colorectal, and endometrial cancers: a systematic review.

Journal article Cancer Epidemiol Biomarkers Prev · November 2013 Oral contraceptives may influence the risk of certain cancers. As part of the AHRQ Evidence Report, Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer, we conducted a systematic review to estimate associations between oral contraceptive us ... Full text Link to item Cite

In reply.

Journal article Obstet Gynecol · November 2013 Full text Link to item Cite

Cost effectiveness of alternative strategies for incorporating bevacizumab into the primary treatment of ovarian cancer.

Journal article Cancer · October 15, 2013 BACKGROUND: The objective of this study was to evaluate the comparative effectiveness of strategies that incorporated bevacizumab into the primary platinum-based treatment of ovarian cancer: 1) no bevacizumab; 2) concurrent and maintenance bevacizumab for ... Full text Link to item Cite

Ovarian cancer, version 2.2013.

Journal article J Natl Compr Canc Netw · October 1, 2013 These NCCN Guidelines Insights focus on the major updates to the 2013 NCCN Guidelines for Ovarian Cancer. Four updates were selected based on recent important updates in the guidelines and on debate among panel members about recent clinical trials. The top ... Full text Link to item Cite

How much is another randomized trial of lymph node dissection in endometrial cancer worth? A value of information analysis.

Journal article Gynecol Oncol · October 2013 OBJECTIVE: This study aimed to assess the value of a randomized controlled trial (RCT) of lymph node dissection (LND) at the time of hysterectomy for high-risk subsets of women with endometrial cancer. METHODS: A modified Markov decision model compared rou ... Full text Link to item Cite

Palliative and hospice care in gynecologic cancer: a review.

Journal article Gynecol Oncol · October 2013 Despite the increasing availability of palliative care, oncology providers often misunderstand and underutilize these resources. The goals of palliative care are relief of suffering and provision of the best possible quality of life for both the patient an ... Full text Link to item Cite

Cost analysis of colposcopy for abnormal cytology in post-treatment surveillance for cervical cancer.

Journal article Gynecol Oncol · September 2013 OBJECTIVE: The aim of this study was to estimate cost and outcomes associated with colposcopy following abnormal Pap for women with a history of cervical cancer. METHODS: Decision models compared the costs and number of isolated local recurrences (ILR) det ... Full text Link to item Cite

Cost-effectiveness of early palliative care intervention in recurrent platinum-resistant ovarian cancer.

Journal article Gynecol Oncol · September 2013 OBJECTIVE: To determine if early palliative care intervention in patients with recurrent, platinum-resistant ovarian cancer is potentially cost saving or cost-effective. METHODS: A decision model with a 6 month time horizon evaluated routine care versus ro ... Full text Link to item Cite

Are supportive care-based treatment strategies preferable to standard chemotherapy in recurrent cervical cancer?

Journal article Gynecol Oncol · August 2013 OBJECTIVE: Recurrent cervical cancer has a poor prognosis despite aggressive treatment. We evaluate the comparative-effectiveness of four management strategies in recurrent cervix cancer incorporating risk prognostication categories derived from pooled col ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal article Obstet Gynecol · August 2013 OBJECTIVE: To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. DATA SOURCES: We searched PubMed, Embas ... Full text Link to item Cite

Timing of end-of-life care discussion with performance on end-of-life quality indicators in ovarian cancer.

Journal article Gynecol Oncol · July 2013 OBJECTIVES: (1) To describe the prevalence, timing and setting of documented end-of-life (EOL) discussions in patients with advanced ovarian cancer; and (2) to assess the impact of timing and setting of documented end-of-life discussions on EOL quality car ... Full text Link to item Cite

A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy.

Journal article Gynecol Oncol · July 2013 OBJECTIVES: The efficacy and safety of bevacizumab and docetaxel were evaluated in women who developed recurrent epithelial ovarian, fallopian, or peritoneal cancer within 12 months of platinum-based therapy. METHODS: Patients received docetaxel (40 mg/m(2 ... Full text Link to item Cite

Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis.

Journal article Obstet Gynecol · July 2013 OBJECTIVE: To estimate the overall reduction in ovarian cancer risk associated with the use of oral contraceptive pills (OCPs) and whether reduction in risk is affected by specifics of OCP use, such as formulation or duration of use. DATA SOURCES: We searc ... Full text Link to item Cite

Preference-based utility scores for adverse events associated with the treatment of gynecologic cancers.

Journal article Int J Gynecol Cancer · July 2013 OBJECTIVE: Our goals were to (1) define a set of descriptive health states related to adverse events (AEs) associated with gynecologic cancer treatment with radical surgery and chemoradiation and (2) derive a set of quality of life-related utility scores c ... Full text Link to item Cite

Oral contraceptive use for the primary prevention of ovarian cancer.

Journal article Evid Rep Technol Assess (Full Rep) · June 2013 OBJECTIVE: To estimate the overall balance of harms and benefits from the potential use of oral contraceptives (OCs) for the primary prevention of ovarian cancer DATA SOURCES: We searched PubMed®, Embase®, the Cochrane Database of Systematic Reviews, and C ... Link to item Cite

Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer.

Journal article Int J Gynecol Cancer · June 2013 OBJECTIVES: (1) To determine whether use of a PARP inhibitor or (2) BRCA1/2 mutation testing followed by a PARP inhibitor for test positives is potentially cost-effective for maintenance treatment of platinum-sensitive recurrent high-grade serous ovarian c ... Full text Link to item Cite

The impact of postoperative nausea and vomiting prophylaxis with dexamethasone on postoperative wound complications in patients undergoing laparotomy for endometrial cancer.

Journal article Anesth Analg · May 2013 BACKGROUND: Dexamethasone is widely used for postoperative nausea and vomiting (PONV) prophylaxis. However, there are limited data on the risk of wound complications associated with single-dose dexamethasone use for this purpose. We performed this retrospe ... Full text Link to item Cite

Predictors of reduced relative dose intensity and its relationship to mortality in women receiving multi-agent chemotherapy for epithelial ovarian cancer.

Journal article Gynecol Oncol · April 2013 OBJECTIVE: There is limited information concerning the role of relative dose intensity (RDI) on clinical outcomes in solid tumors. The objectives of our study were to evaluate the prognostic significance of RDI and predictors of reduced RDI in women with n ... Full text Link to item Cite

Screening for cervical cancer: a modeling study for the US Preventive Services Task Force.

Journal article J Low Genit Tract Dis · April 2013 OBJECTIVE: This study addresses the following 3 questions posed by the US Preventive Services Task Force: (1) at what age should screening for cervical cancer begin; (2) at what age should screening for cervical cancer end; and (3) how do the benefits and ... Full text Link to item Cite

Comparison of methods to estimate health state utilities for ovarian cancer using quality of life data: a Gynecologic Oncology Group study.

Journal article Gynecol Oncol · February 2013 BACKGROUND: Cost-effectiveness/cost-utility analyses are increasingly needed to inform decisions about care. Algorithms have been developed using the Functional Assessment of Cancer Therapy (FACT) quality of life instrument to estimate utility weights for ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal article Obstetrics and Gynecology · January 1, 2013 To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. We searched PubMed, Embase, the Cochrane Database ... Cite

A multicenter evaluation of adjuvant therapy in women with optimally resected stage IIIC endometrial cancer.

Journal article Gynecol Oncol · January 2013 OBJECTIVE: To determine if there is an advantage to combination chemotherapy and radiation for optimally resected stage IIIC endometrial cancer (EC). METHODS: A multicenter retrospective analysis of patients with EC from 1991 to 2008 was conducted. Inclusi ... Full text Link to item Cite

TP53 Status is Associated with Thrombospondin1 Expression In vitro.

Journal article Front Oncol · 2013 OBJECTIVES: To elucidate the association between thrombospondin1 (THBS1) expression and TP53 status and THBS1 promoter methylation in epithelial ovarian cancer (EOC). METHODS: Epithelial ovarian cancer cell lines with known TP53 status were analyzed for TH ... Full text Link to item Cite

A branching process model of ovarian cancer.

Journal article J Theor Biol · December 7, 2012 Ovarian cancer is usually diagnosed at an advanced stage, rendering the possibility of cure unlikely. To date, no cost-effective screening test has proven effective for reducing mortality. To estimate the window of opportunity for ovarian cancer screening, ... Full text Link to item Cite

Predictors of failure to perform pelvic peritoneal cytology in endometrial cancer staging surgery.

Journal article J Clin Oncol · December 2012 201 Background: The Federation of Gynecology and Obstetrics (FIGO) staging system and the National Comprehensive Cancer Network (NCCN) guidelines for endometrial cancer recommend performing pelvic peritoneal cytology to look for the presence of cancer cell ... Full text Link to item Cite

Cost effectiveness of concurrent gemcitabine and cisplatin with radiation followed by adjuvant gemcitabine and cisplatin in patients with stages IIB to IVA carcinoma of the cervix.

Journal article Gynecol Oncol · November 2012 OBJECTIVE: A recent phase III trial reported gemcitabine with cisplatin chemoradiation followed by 2 cycles of gemcitabine and cisplatin (G) significantly improved progression-free (PFS) and overall survival (OS) compared to standard cisplatin chemoradiati ... Full text Link to item Cite

Beyond mere obesity: effect of increasing obesity classifications on hysterectomy outcomes for uterine cancer/hyperplasia.

Journal article Gynecol Oncol · November 2012 OBJECTIVE: To assess the impact of obesity severity on hysterectomy outcomes for uterine hyperplasia/cancer. METHODS: The data from women undergoing hysterectomies for endometrial hyperplasia/uterine cancer with a BMI≥30 kg/m(2) were abstracted from record ... Full text Link to item Cite

Surgical staging for endometrial cancer in the elderly - Is there a role for lymphadenectomy?

Journal article Obstetrical and Gynecological Survey · November 1, 2012 Full text Cite

Ovarian cancer, version 3.2012.

Journal article J Natl Compr Canc Netw · November 1, 2012 These NCCN Guidelines Insights focus on the major updates for the 2012 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Ovarian Cancer by describing how and why the new recommendations were made. The 6 update topics were selected based o ... Full text Link to item Cite

A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer.

Journal article Clin Cancer Res · October 1, 2012 PURPOSE: We conducted a phase I study of dasatinib, an oral SRC-family tyrosine kinase inhibitor, in combination with paclitaxel and carboplatin in the treatment of advanced and recurrent epithelial ovarian cancer. EXPERIMENTAL DESIGN: The primary objectiv ... Full text Link to item Cite

A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma.

Journal article Gynecol Oncol · October 2012 OBJECTIVE: To evaluate the impact of adjuvant post-operative therapy in women with early stage uterine carcinosarcoma. METHODS: After IRB approval was obtained at all sites, a multi-center retrospective study of women with FIGO stage I-II uterine carcinosa ... Full text Link to item Cite

Minimally invasive surgery versus laparotomy in women with high grade endometrial cancer: a multi-site study performed at high volume cancer centers.

Journal article Gynecol Oncol · August 2012 OBJECTIVE: The study aim was to compare outcomes in women with high-grade endometrial cancer (EC) who underwent surgical staging via minimally invasive surgery (MIS) versus laparotomy. METHODS: This is a retrospective, multi-institutional cohort study of p ... Full text Link to item Cite

Surgical staging for endometrial cancer in the elderly - is there a role for lymphadenectomy?

Journal article Gynecol Oncol · July 2012 OBJECTIVES: We sought to evaluate the effect of systematic lymphadenectomy (LND) on endometrial cancer-specific survival in an elderly population. METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) program from 1988 to ... Full text Link to item Cite

A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer.

Journal article Cancer · July 1, 2012 BACKGROUND: The aim of this randomized clinical trial was to evaluate the efficacy and safety of combination (cDC) and sequential (sDC) weekly docetaxel and carboplatin in women with recurrent platinum-sensitive epithelial ovarian cancer (EOC). METHODS: Pa ... Full text Link to item Cite

Predictors of severe and febrile neutropenia during primary chemotherapy for ovarian cancer.

Journal article Gynecol Oncol · June 2012 OBJECTIVE: To identify factors that increase the risk of neutropenic events in women with advanced ovarian carcinoma receiving initial chemotherapy. METHODS: Multi-center retrospective study of women with FIGO stage III-IV epithelial ovarian cancer treated ... Full text Link to item Cite

Economic impact of paclitaxel shortage in patients with newly diagnosed ovarian cancer.

Journal article Gynecol Oncol · June 2012 OBJECTIVE: To determine the potential economic impact of a paclitaxel drug shortage in patients with newly diagnosed, untreated ovarian cancer. METHODS: A modified Markov state transition model with a 6 cycle time horizon compared two scenarios: (1) Standa ... Full text Link to item Cite

The influence of radiation modality and lymph node dissection on survival in early-stage endometrial cancer.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 BACKGROUND: The appropriate uses of lymph node dissection (LND) and adjuvant radiation therapy (RT) for Stage I endometrial cancer are controversial. We explored the impact of specific RT modalities (whole pelvic RT [WPRT], vaginal brachytherapy [VB]) and ... Full text Link to item Cite

Health economics of screening for gynaecological cancers.

Journal article Best Pract Res Clin Obstet Gynaecol · April 2012 In this chapter, we summarise findings from recent cost-effectiveness analyses of screening for cervical cancer and ovarian cancer. We begin with a brief summary of key issues that affect the cost-effectiveness of screening, including disease burden, and a ... Full text Link to item Cite

Cost-effectiveness of combination versus sequential docetaxel and carboplatin for the treatment of platinum-sensitive, recurrent ovarian cancer.

Journal article Cancer · January 15, 2012 BACKGROUND: In a randomized controlled trial (RCT) of patients with recurrent, platinum-sensitive ovarian cancer, the combination weekly docetaxel and carboplatin was associated a with progression-free survival (PFS) of 13.7 months compared with 8.4 months ... Full text Link to item Cite

Cost analysis of abdominal, laparoscopic, and robotic-assisted myomectomies.

Journal article J Minim Invasive Gynecol · 2012 STUDY OBJECTIVE: To perform a cost-minimization analysis of abdominal, traditional laparoscopic and robotic-assisted myomectomy. DESIGN: Cost analysis (Canadian Task Force Classification III). SETTING: Academic medical center. PATIENTS: Women undergoing my ... Full text Link to item Cite

Health-related quality of life outcomes of docetaxel/carboplatin combination therapy vs. sequential therapy with docetaxel then carboplatin in patients with relapsed, platinum-sensitive ovarian cancer: results from a randomized clinical trial.

Journal article Gynecol Oncol · December 2011 OBJECTIVES: A phase II clinical trial compared docetaxel in combination with carboplatin to sequential single agent docetaxel followed by carboplatin for treatment of recurrent platinum-sensitive ovarian, peritoneal, or tubal cancer. This manuscript report ... Full text Link to item Cite

The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.

Journal article Gynecol Oncol · November 2011 OBJECTIVES: To elucidate the regulation of MASPIN expression in epithelial ovarian cancer (EOC) and associations with p53 status and MASPIN promoter methylation. METHODS: Seven EOC cell lines and 110 advanced stage EOC specimens were analyzed for MASPIN pr ... Full text Link to item Cite

Preoperative screening strategies for bacterial vaginosis prior to elective hysterectomy: a cost comparison study.

Journal article Am J Obstet Gynecol · November 2011 OBJECTIVE: The purpose of this study is to compare costs of 3 strategies for women undergoing hysterectomy: (1) test all patients for bacterial vaginosis; treat if positive; (2) treat all patients for bacterial vaginosis; (3) neither test nor treat patient ... Full text Link to item Cite

Retrospective review of an intraoperative algorithm to predict lymph node metastasis in low-grade endometrial adenocarcinoma.

Journal article Gynecol Oncol · October 2011 OBJECTIVE: To validate the Mayo algorithm to intraoperatively identify women with endometrial cancer in whom lymphadenectomy may be safely omitted. METHODS: A multi-center retrospective chart review 1977-2010 was completed using two independent institution ... Full text Link to item Cite

Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer.

Journal article Gynecol Oncol · September 2011 OBJECTIVE: To evaluate the costs and effectiveness of thromboprophylaxis strategies following laparotomy for ovarian cancer. METHODS: We constructed a decision model to evaluate six strategies for management of postoperative venous thromboembolism (VTE) ri ... Full text Link to item Cite

Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer.

Journal article Am J Obstet Gynecol · August 2011 OBJECTIVE: The objective of the study was to compare adverse event rates between laparoscopic vs open surgery for endometrial cancer. STUDY DESIGN: This was a retrospective cohort study comparing 107 women who underwent laparoscopy with 269 age- and body m ... Full text Link to item Cite

Utility scores and treatment preferences for clinical early-stage cervical cancer.

Journal article Value Health · June 2011 OBJECTIVES: To determine utility scores for health states relevant to the treatment of early-stage, high-risk cervical cancer. METHODS: Seven descriptive health states incorporating the physical and emotional aspects of medical treatment, recovery, and pro ... Full text Link to item Cite

Relationship between relative dose intensity and mortality in women receiving combination chemotherapy for stage III-IV epithelial ovarian cancer.

Journal article J Clin Oncol · May 20, 2011 5084 Background: Although considerable progress has been made in the treatment of advanced ovarian cancer, complications of both disease and treatment limit long term survival. Further research is needed on specific patient- and treatment-related factors t ... Link to item Cite

Development of an ovarian cancer screening decision model that incorporates disease heterogeneity: implications for potential mortality reduction.

Journal article Cancer · February 1, 2011 BACKGROUND: Pathologic and genetic data suggest that epithelial ovarian cancer may consist of indolent and aggressive phenotypes. The objective of the current study was to estimate the impact of a 2-phenotype paradigm of epithelial ovarian cancer on the mo ... Full text Link to item Cite

Analgesic and antiemetic needs following minimally invasive vs open staging for endometrial cancer.

Journal article Am J Obstet Gynecol · January 2011 OBJECTIVE: We sought to assess perioperative outcomes of minimally invasive vs open endometrial cancer staging procedures. STUDY DESIGN: A total of 181 consecutive patients underwent open or minimally invasive hysterectomy with or without lymphadenectomy. ... Full text Link to item Cite

Epithelial ovarian cancer.

Journal article J Natl Compr Canc Netw · January 2011 Full text Link to item Cite

A review of cost-effectiveness studies in ovarian cancer.

Journal article Cancer Control · January 2011 BACKGROUND: Ovarian cancer is the fifth leading cause of all cancer-related deaths among women. While the costs of diagnosis and treatment impact the affected individual and the health system, the most important costs for the patient are often the pain and ... Full text Link to item Cite

Projecting the need for gynecologic oncologists for the next 40 years.

Journal article Obstet Gynecol · December 2010 OBJECTIVE: To estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the United States over the next 40 years. METHODS: Using population projections from the U.S. Census Bureau and incidence and mortality rates from Surveil ... Full text Link to item Cite

Cost comparison among robotic, laparoscopic, and open hysterectomy for endometrial cancer.

Journal article Obstet Gynecol · September 2010 OBJECTIVE: To use decision modeling to compare the costs associated with robotic, laparoscopic, and open hysterectomy for the treatment of endometrial cancer. METHODS: Three separate models were used, each with sensitivity analysis: 1) a societal perspecti ... Full text Link to item Cite

Impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer.

Journal article Am J Obstet Gynecol · August 2010 OBJECTIVE: We sought to estimate mean costs of chemotherapy treatment for recurrent ovarian cancer with or without use of a chemoresponse assay. STUDY DESIGN: We estimated mean costs for 3 groups: (1) assay assisted: 75 women who received oncologist's choi ... Full text Link to item Cite

Cost-minimization analysis of robotic-assisted, laparoscopic, and abdominal sacrocolpopexy.

Journal article J Minim Invasive Gynecol · 2010 STUDY OBJECTIVE: To perform a cost-minimization analysis comparing robotic-assisted, laparoscopic, and abdominal sacrocolpopexy. DESIGN: Cost-minimization analysis using a micro-costing approach (Canadian Task Force classification III). MEASUREMENTS AND MA ... Full text Link to item Cite

Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study.

Journal article Gynecol Oncol · December 2009 OBJECTIVES: The Gynecologic Oncology Group (GOG) examined the association between the relative expression of the DeltaNp63alpha isoform and clinicopathologic variables, p53 status, angiogenic markers, progression-free survival (PFS) and overall survival (O ... Full text Link to item Cite

An updated clinicopathologic study of early-stage uterine papillary serous carcinoma (UPSC).

Journal article Gynecol Oncol · November 2009 OBJECTIVES: Stage I-II uterine papillary serous carcinoma (UPSC) patients have a significant risk for extrapelvic recurrence. However, clinicopathologic risk factors for recurrence are not well understood. This study was undertaken to define the prognostic ... Full text Link to item Cite

A multicenter evaluation of sequential multimodality therapy and clinical outcome for the treatment of advanced endometrial cancer.

Journal article Gynecol Oncol · September 2009 OBJECTIVES: The appropriate sequencing of chemotherapy and radiation for the treatment of advanced endometrial cancer has not yet been determined. We sought to evaluate the outcome and adverse effects in patients with advanced stage endometrial cancer trea ... Full text Link to item Cite

Multicenter analysis of recurrence and survival in stage IIIA endometrial cancer.

Journal article Gynecol Oncol · August 2009 OBJECTIVE: To determine factors related to recurrence and survival in women with stage IIIA endometrial cancer; to examine outcomes of women with IIIA1 disease. METHODS: Multi-institutional analysis of women with stage IIIA endometrial carcinoma undergoing ... Full text Link to item Cite

Evaluation of two management strategies for preoperative grade 1 endometrial cancer.

Journal article Obstet Gynecol · July 2009 OBJECTIVE: To compare the practices, adjuvant treatment, and outcomes of patients with preoperatively assessed grade 1 endometrioid endometrial cancer between two academic gynecologic oncology centers that use different treatment strategies. METHODS: A ret ... Full text Link to item Cite

Cost-effectiveness analysis of annual screening strategies for endometrial cancer.

Journal article Am J Obstet Gynecol · June 2009 OBJECTIVE: The objective of the study was to determine the cost-effectiveness of annual screening tests for endometrial cancer. STUDY DESIGN: Markov state transition model of the natural history of endometrial cancer used as the design for the study. Incid ... Full text Link to item Cite

Can primary recurrences in surgical stage I-II uterine papillary serous carcinoma (UPSC) patients be salvaged?

Journal article J Clin Oncol · May 20, 2009 e16503 Background: There is an absence of data in the literature on salvage rates for vaginal, pelvic, and extra-pelvic recurrences for early-stage UPSC patients (pts). The purpose of this study is to determine whether primary recurrences can be salvaged w ... Link to item Cite

Platinum/taxane-based chemotherapy with or without radiation therapy favorably impacts survival outcomes in stage I uterine papillary serous carcinoma.

Journal article Cancer · May 15, 2009 BACKGROUND: A study was undertaken to determine recurrence patterns and survival outcomes of stage I uterine papillary serous carcinoma (UPSC) patients. METHODS: A retrospective, multi-institutional study of stage I UPSC patients diagnosed from 1993 to 200 ... Full text Link to item Cite

Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment.

Journal article Gynecol Oncol · May 2009 OBJECTIVES: (1) To define a set of health state descriptions related to screening, diagnosis, prognosis, and toxicities relevant to ovarian cancer; (2) To derive a set of quality of life-related utilities to be used for cost-effectiveness analyses. METHODS ... Full text Link to item Cite

Cost-effectiveness of botulinum toxin a versus anticholinergic medications for idiopathic urge incontinence.

Journal article J Urol · May 2009 PURPOSE: We assessed the cost-effectiveness of botulinum toxin A injection compared to anticholinergic medications for the treatment of idiopathic urge incontinence. MATERIALS AND METHODS: A Markov decision analysis model was developed to compare the costs ... Full text Link to item Cite

Attitudes regarding the use of hematopoietic colony-stimulating factors and maintenance of relative dose intensity among gynecologic oncologists.

Journal article Int J Gynecol Cancer · April 2009 OBJECTIVE: To assess the attitudes regarding the use of colony-stimulating factor (CSF) and the maintenance of relative dose intensity (RDI) by gynecologic oncologists during the administration of chemotherapy to patients with epithelial ovarian cancer. ME ... Full text Link to item Cite

Cost effectiveness of a test to detect metastases for endometrial cancer.

Journal article Gynecol Oncol · March 2009 OBJECTIVE: To estimate the potential cost-effectiveness of a hypothetical test to screen for lymph node metastases in women with newly diagnosed, apparent early stage endometrial cancer. METHODS: A decision model was constructed to inform a choice between ... Full text Link to item Cite

Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.

Journal article Gynecol Oncol · March 2009 OBJECTIVES: The aims of this study were to examine prognostic significance of microvessel density (MVD) in previously-untreated, advanced epithelial ovarian cancer (EOC) and explore associations between MVD and factors that affect angiogenesis. METHODS: MV ... Full text Link to item Cite

The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma.

Journal article Gynecol Oncol · March 2009 OBJECTIVE: We sought to assess the accuracy of a preoperative grade 1 designation and role of lymphadenectomy in women with preoperative grade 1 endometrial cancer. METHODS: A retrospective analysis of patients diagnosed with preoperative grade 1 endometri ... Full text Link to item Cite

Stage II uterine papillary serous carcinoma: Carboplatin/paclitaxel chemotherapy improves recurrence and survival outcomes.

Journal article Gynecol Oncol · March 2009 OBJECTIVES: To determine recurrence patterns and survival outcomes of stage II uterine papillary serous carcinoma (UPSC) patients treated by various modalities with an emphasis on carboplatin/paclitaxel-based chemotherapy (CT)+/-radiotherapy (RT). METHODS: ... Full text Link to item Cite

Robotic-assisted laparoscopic gynecologic procedures in a fellowship training program.

Journal article JSLS · 2009 BACKGROUND AND OBJECTIVE: The robotic surgical platform is an alternative technique to traditional laparoscopy and requires the development of new surgical skills for both the experienced surgeon and trainee. Our goal was to perform an early evaluation of ... Full text Link to item Cite

Relationship between tamoxifen use and high risk endometrial cancer histologic types.

Journal article Gynecol Oncol · January 2009 OBJECTIVES: We wished to determine whether a pre-existing diagnosis of breast cancer or the use of tamoxifen among patients with pre-existing breast cancer influences the histologic type of subsequently diagnosed endometrial carcinoma, the interval between ... Full text Link to item Cite

Reducing ovarian cancer mortality through screening: Is it possible, and can we afford it?

Journal article Gynecol Oncol · November 2008 OBJECTIVE: Ovarian cancer is a leading cause of cancer-related deaths among women. Given the low prevalence of this disease, the effectiveness of screening strategies has not been established. We wished to estimate the clinical impact and cost-effectivenes ... Full text Link to item Cite

Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence.

Journal article Gynecol Oncol · September 2008 OBJECTIVE: To determine the utility of novel combinations of biomarkers, using both a one-step and two-step assay format, to distinguish serum of early ovarian cancer patients from that of healthy controls and to discern the utility of these biomarkers in ... Full text Link to item Cite

Cost effectiveness of intraperitoneal compared with intravenous chemotherapy for women with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study.

Journal article J Clin Oncol · September 1, 2008 PURPOSE: To determine the cost effectiveness of intraperitoneal versus intravenous regimens for adjuvant treatment of optimally resected stage III ovarian cancer. PATIENTS AND METHODS: A decision model was developed to compare the cost effectiveness at 7-, ... Full text Link to item Cite

Ovarian cancer. Clinical practice guidelines in oncology.

Journal article J Natl Compr Canc Netw · September 2008 Full text Link to item Cite

Medical and surgical treatment of placenta percreta to optimize bladder preservation.

Journal article Obstet Gynecol · August 2008 BACKGROUND: Placenta percreta is associated with significant morbidity and mortality. Interventions are dictated by hemodynamic stability, desire to retain future fertility, and efforts to reduce surgical morbidity at time of delivery. CASES: Two cases of ... Full text Link to item Cite

Endometrial cancer: multiplexed Luminex approaches for early detection.

Journal article Expert Opin Med Diagn · May 2008 BACKGROUND: Endometrial carcinoma is the most common gynecologic cancer. Despite the advances that have been made in other cancers, both the annual incidence of and the death rate associated with endometrial cancer appear to be rising, both in the US and a ... Full text Link to item Cite

Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.

Journal article Biomark Insights · February 1, 2008 Tumor hypoxia is associated with adverse outcome in many malignancies. The goal of this study was to determine if elevated expression of carbonic anhydrase IX (CAIX), a biomarker of hypoxia, predicts for recurrence in early-stage cervical cancer. The chart ... Full text Link to item Cite

Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer.

Journal article Gynecol Oncol · December 2007 OBJECTIVE: Currently available tumor markers for ovarian cancer are still inadequate in both sensitivity and specificity to be used for population-based screening. Artificial neural network (ANN) as a modeling tool has demonstrated its ability to assimilat ... Full text Link to item Cite

Primary surgery versus chemoradiation in the treatment of IB2 cervical carcinoma: a cost effectiveness analysis.

Journal article Gynecol Oncol · December 2007 OBJECTIVES: To estimate the relative cost-effectiveness of treatments for patients with FIGO stage IB2 cervical cancer and no evidence of metastasis as determined by combination of positron emission tomography/computed tomography (PET/CT). METHODS: A Marko ... Full text Link to item Cite

The role of multi-modality adjuvant chemotherapy and radiation in women with advanced stage endometrial cancer.

Journal article Gynecol Oncol · November 2007 OBJECTIVE: : The optimal adjuvant therapy for women with stages III and IV endometrial cancer following surgical staging and cytoreductive surgery is controversial. We sought to determine the outcome of patients with advanced stage endometrial cancer treat ... Full text Link to item Cite

Management of platinum-sensitive recurrent ovarian cancer: a cost-effectiveness analysis.

Journal article Gynecol Oncol · November 2007 Featured Publication OBJECTIVE: We wished to compare the cost-effectiveness of three chemotherapy regimens for treatment of recurrent platinum-sensitive ovarian cancer. METHODS: A Markov decision tree was constructed comparing three chemotherapy regimens: (1) carboplatin alone ... Full text Link to item Cite

Cost-effectiveness of adjuvant radiotherapy in intermediate risk endometrial cancer.

Journal article Gynecol Oncol · August 2007 OBJECTIVES: Endometrial cancer is the most common gynecologic malignancy in the United States. Adjuvant radiotherapy in patients with intermediate risk disease (stage IB, IC, and occult stage II) is controversial. Despite no proven survival advantage, a si ... Full text Link to item Cite

Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study.

Journal article Gynecol Oncol · July 2007 OBJECTIVES: The aim of this study was to explore the co-expression and prognostic relevance of thrombospondin-1 (THBS-1), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR-1) in epithelial ovarian c ... Full text Link to item Cite

Outcomes in surgical stage I uterine papillary serous carcinoma.

Journal article Gynecol Oncol · June 2007 Featured Publication OBJECTIVE: The optimal management of patients with stage I uterine papillary serous carcinoma (UPSC) is unclear. We sought to determine whether outcomes of women with surgical stage I UPSC differ with and without adjuvant therapy. METHODS: Retrospective mu ... Full text Link to item Cite

Clinical and pathologic correlates in surgical stage II endometrial carcinoma.

Journal article Obstet Gynecol · May 2007 OBJECTIVE: To identify the surgical, pathologic, and therapeutic factors that influence outcome in patients with surgical stage II endometrial adenocarcinoma. METHODS: All patients with comprehensively staged stage II endometrial adenocarcinoma were identi ... Full text Link to item Cite

Weekly low-dose paclitaxel and carboplatin in the treatment of advanced or recurrent cervical and endometrial cancer.

Journal article Int J Clin Oncol · February 2007 BACKGROUND: The purpose of this study was to evaluate the toxicity profile of weekly low-dose paclitaxel and carboplatin in patients with gynecologic malignancies. METHODS: Patients had measurable disease defined by clinical examination or radiographic stu ... Full text Link to item Cite

The prognostic significance of positive peritoneal cytology and adnexal/serosal metastasis in stage IIIA endometrial cancer.

Journal article Gynecol Oncol · February 2007 Featured Publication OBJECTIVE: The clinical significance and optimal management of patients with stage IIIA endometrial cancer are controversial. We sought to determine whether recurrence and survival of patients with stage IIIA endometrial cancer differ with surgical patholo ... Full text Link to item Cite

Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience.

Journal article Int J Gynecol Cancer · 2007 The objective of this study was to evaluate the treatment outcomes and risk factors of women with surgical stage I endometrial adenocarcinoma who were initially treated with surgery alone and subsequently developed isolated vaginal recurrences. Patients wi ... Full text Link to item Cite

Comparison of gracilis and rectus abdominis myocutaneous flap neovaginal reconstruction performed during radical pelvic surgery: flap-specific morbidity.

Journal article Int J Gynecol Cancer · 2007 To compare flap-specific complications of gracilis myocutaneous (GM) and rectus abdominis myocutaneous (RAM) flap neovaginal reconstructions after radical pelvic surgery. The study was a single-institution retrospective review of patients undergoing concur ... Full text Link to item Cite

Genomic tests for ovarian cancer detection and management.

Journal article Evid Rep Technol Assess (Full Rep) · October 2006 OBJECTIVES: To assess the evidence that the use of genomic tests for ovarian cancer screening, diagnosis, and treatment leads to improved outcomes. DATA SOURCES: PubMed and reference lists of recent reviews. REVIEW METHODS: We evaluated tests for: (a) sing ... Link to item Cite

Pelvic lymph node count is an important prognostic variable for FIGO stage I and II endometrial carcinoma with high-risk histology.

Journal article Gynecol Oncol · July 2006 OBJECTIVE: To determine whether pelvic lymph node count is associated with patterns of recurrence or survival in patients with FIGO stage I and II endometrial cancer. METHODS: Single institution retrospective study of 467 patients with FIGO stage I and II ... Full text Link to item Cite

A comparison of combination docetaxel/carboplatin versus sequential docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer.

Journal article J Clin Oncol · June 20, 2006 5092 Background: Combination paclitaxel and platinum-based chemotherapy has been shown to improve survival in patients with recurrent platinum-sensitive ovarian cancer. However, the incidence of neurotoxicity was significantly greater with combination ther ... Link to item Cite

Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study.

Journal article Gynecol Oncol · June 2006 OBJECTIVE: This study examined MASPIN expression in human ovarian cancer, and explored the association between MASPIN and prognosis in patients with advanced stage disease treated with first-line cisplatin, carboplatin and/or paclitaxel. METHODS: Frozen pr ... Full text Link to item Cite

Management of adnexal mass.

Journal article Evid Rep Technol Assess (Full Rep) · February 2006 OBJECTIVES: To assess diagnostic strategies for distinguishing benign from malignant adnexal masses. DATA SOURCES: MEDLINE(R) and reference lists of recent reviews; discharge data from the Nationwide Inpatient Sample. REVIEW METHODS: The major diagnostic m ... Link to item Cite

Resection of lymph node metastases influences survival in stage IIIC endometrial cancer.

Journal article Gynecol Oncol · December 2005 Featured Publication OBJECTIVE: Surgical staging of endometrial cancer identifies those patients with microscopic metastatic disease most likely to benefit from adjuvant therapy and may also confer therapeutic benefit. Our objective was to compare survival of patients who unde ... Full text Link to item Cite

Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer.

Journal article J Clin Oncol · June 1, 2005 Featured Publication PURPOSE: Selective lymphadenectomy is widely accepted in the management of endometrial cancer. Purported benefits are individualization of adjuvant therapy based on extent of disease and resection of occult metastases. Our goal was to assess effects of the ... Full text Link to item Cite

Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal article Int J Hyperthermia · June 2005 OBJECTIVE: A phase I/II study of Doxil combined with whole abdomen hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase both liposomal delivery and drug extravasa ... Full text Link to item Cite

Rectus abdominis myocutaneous and myoperitoneal flaps for neovaginal reconstruction after radical pelvic surgery: comparison of flap-related morbidity.

Journal article Gynecol Oncol · May 2005 PURPOSE: To compare flap-specific complications of rectus abdominis myocutaneous (RAM) and myoperitoneal (RAMP) flap neovagina reconstructions performed concurrently with radical pelvic procedures. MATERIALS AND METHODS: Retrospective single institution ch ... Full text Link to item Cite

FDG-PET for management of cervical and ovarian cancer.

Journal article Gynecol Oncol · April 2005 Featured Publication OBJECTIVE: To assess the diagnostic performance of Positron Emission Tomography using fluorodeoxyglucose (FDG-PET) in comparison to conventional imaging modalities in the assessment of patients with cervical and ovarian cancer. METHODS: Studies published b ... Full text Link to item Cite

Rectus abdominis myocutaneous flaps for neovaginal reconstruction after radical pelvic surgery.

Journal article Int J Gynecol Cancer · 2005 The objective of this article is to compare the flap-specific complications associated with vertical (VRAM) and transverse (TRAM) rectus abdominis myocutaneous flap vaginal reconstructions performed during radical pelvic procedures. A retrospective chart r ... Full text Link to item Cite

Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions.

Journal article J Clin Oncol · October 15, 2004 PURPOSE: In CA-125-based ovarian cancer screening trials, overall specificity and screening sensitivity of ultrasound after an elevated CA-125 exceeded 99.6% and 70%, respectively, thereby yielding a positive predictive value (PPV) exceeding 10%. However, ... Full text Link to item Cite

Phase I/II trial of intravenous liposomal doxorubicin and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal article J Clin Oncol · July 15, 2004 5089 Background: A phase I/II study of liposomal doxorubicin combined with whole abdominal hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase liposomal extravas ... Link to item Cite

Phase I/II trial of combination topotecan and vinorelbine in patients with refractory gynecologic cancer.

Journal article J Clin Oncol · July 15, 2004 5152 Background: Topotecan (T) and vinorelbine (V) have shown efficacy in recurrent ovarian and cervical cancer. The purpose of this trial was to determine the recommended dose of combination T and V and to assess its efficacy in patients with refractory g ... Link to item Cite

Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancer.

Journal article Gynecol Oncol · May 2004 Featured Publication OBJECTIVE: We wished to evaluate survival and adverse outcomes of patients with stage IB2 cervical cancer treated primarily with radical hysterectomy and lymphadenectomy. METHODS: A review was performed of all patients undergoing primary radical hysterecto ... Full text Link to item Cite

Gene expression patterns that characterize advanced stage serous ovarian cancers.

Journal article J Soc Gynecol Investig · January 2004 OBJECTIVE: To identify gene expression patterns that characterize advanced stage serous ovarian cancers by using microarray expression analysis. METHODS: Using genome-wide expression analysis, we compared a series of 31 advanced stage (III or IV) serous ov ... Full text Link to item Cite

Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study.

Journal article J Clin Oncol · October 15, 2003 PURPOSE: The prognostic significance of p53 mutations and overexpression in advanced epithelial ovarian cancers was examined in primary tumors from 125 patients participating in a Gynecologic Oncology Group randomized phase III treatment protocol. PATIENTS ... Full text Link to item Cite

High dose rate intraoperative radiotherapy for recurrent cervical cancer and nodal disease.

Journal article Gynecol Oncol · October 2003 BACKGROUND: Patients with pelvic sidewall recurrences of cervical cancer have a dismal prognosis. Intraoperative radiation therapy (IORT) has demonstrated encouraging results. Patients have traditionally been excluded from IORT if they had distant metastas ... Full text Link to item Cite

Predictors of clinical outcomes in the laparoscopic management of adnexal masses.

Journal article Obstet Gynecol · August 2003 Featured Publication OBJECTIVE: Laparoscopy has become an accepted approach in the management of adnexal masses. We evaluated clinical outcomes of laparoscopic management of adnexal masses thought to be benign preoperatively. METHODS: We performed a retrospective study of pati ... Full text Link to item Cite

A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma.

Journal article Cancer · July 15, 2003 BACKGROUND: Five randomized studies have demonstrated a benefit derived from adding cisplatin (CDDP)-based chemotherapy to radiotherapy (RT) for treatment of cervical carcinoma. The Dutch Phase III pelvic tumor trial demonstrated a survival and local contr ... Full text Link to item Cite

The role of PET scanning in the detection of recurrent cervical cancer.

Journal article Gynecol Oncol · July 2003 OBJECTIVES: [(18)F] Fluoro-2-deoxyglucose positron emission tomography (FDG PET) has recently been established as a sensitive and specific method of detecting lymph node metastases in newly diagnosed cervical cancer. Little is known about the efficacy of P ... Full text Link to item Cite

The Genetic Etiology of Sporadic Ovarian Cancer

Journal article · January 1, 2003 Epithelial ovarian cancer is known to be the deadliest gynecologic malignancy and is a leading cause of cancer death in women. Genetic alterations disrupt regulation of proliferation, programmed cell death, and senescence thus causing malignant transformat ... Full text Cite

Weekly low-dose carboplatin and paclitaxel in the treatment of recurrent ovarian and peritoneal cancer.

Journal article Gynecol Oncol · January 2003 Featured Publication OBJECTIVES: Weekly paclitaxel alone has moderate activity in the salvage treatment of recurrent ovarian cancer and is associated with a favorable toxicity profile. Combination paclitaxel and carboplatin is a well-established first-line regimen for ovarian ... Full text Link to item Cite

Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations.

Journal article Gynecol Oncol · December 2001 OBJECTIVE: The aim of this study was to test the hypothesis that p53 mutations are less frequent in ovarian cancers with alterations in other genes that regulate G1 progression. METHODS: Expression of G1 stimulatory (cyclins D1 and E, cdk4, Ki67) and inhib ... Full text Link to item Cite

OVX1, macrophage-colony stimulating factor, and CA-125-II as tumor markers for epithelial ovarian carcinoma: a critical appraisal.

Journal article Cancer · December 1, 2001 BACKGROUND: Ovarian carcinoma remains the leading cause of death from gynecologic malignancy in Australia, the Netherlands, and the United States. CA-125-II, the most widely used serum marker, has limited sensitivity and specificity for detecting small-vol ... Full text Link to item Cite

Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.

Journal article J Soc Gynecol Investig · 2001 OBJECTIVE: To determine whether aberrant expression of hormone receptor corepressors or coactivators or defects in estrogen receptor-mediated transcription might underlie resistance of ovarian cancers to hormonal therapy. METHODS: Northern analysis, Wester ... Link to item Cite

Chemotherapy-induced apoptosis in epithelial ovarian cancers.

Journal article Obstet Gynecol · June 1995 OBJECTIVE: To determine whether chemotherapy drugs elicit programmed cell death (apoptosis) in ovarian cancer cells. METHODS: Monolayers of immortalized ovarian cancer cell lines and primary ovarian cancer cells obtained from ascites were grown in the pres ... Full text Link to item Cite

Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta.

Journal article Cancer Res · February 15, 1995 Previously, we found that transforming growth factor beta (TGF-beta) inhibits proliferation of normal human ovarian epithelial cells. In addition, although only 1 of 5 immortalized ovarian cancer cell lines was inhibited, TGF-beta inhibited proliferation o ... Link to item Cite

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

Journal article Cell Growth Differ · December 1994 Transforming growth factor beta (TGF beta) is an important regulator of cellular proliferation. In normal ovarian epithelial cells, TGF beta acts to inhibit growth. However, in ovarian cancer cell lines, this effect is usually lost. Although the regulatory ... Link to item Cite

Pathogenesis of ovarian cancers.

Journal article J Soc Gynecol Investig · 1994 OBJECTIVE: To review our current understanding of the molecular genetic events involved in the development of epithelial ovarian cancers. METHODS: Molecular biologic techniques have been used to examine the role of growth-stimulatory genes (oncogenes) and ... Full text Link to item Cite