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Haywood Laverne Brown

F. Bayard Carter Distinguished Professor Emeritus of Obstetrics and Gynecology
Obstetrics and Gynecology, Maternal Fetal Medicine
Box 3084 Med Ctr, Durham, NC 27710
203 Baker House, Durham, NC 27710

Featured Works


Air embolism during pregnancy.

Journal article Obstet Gynecol · February 2008 Featured Publication Full text Link to item Cite

Indoor air pollution from biomass combustion and respiratory symptoms of women and children in a Zimbabwean village.

Journal article Indoor Air · December 2007 Featured Publication UNLABELLED: Rural areas of developing countries are particularly reliant on biomass for cooking and heating. Women and children in these areas are often exposed to high levels of pollutants from biomass combustion that is associated with a range of respira ... Full text Link to item Cite

The "Hispanic paradox": an investigation of racial disparity in pregnancy outcomes at a tertiary care medical center.

Journal article Am J Obstet Gynecol · August 2007 Featured Publication OBJECTIVE: The purpose of this study was to examine racial disparities and the "Hispanic paradox" in pregnancy outcomes at a tertiary-care medical center. STUDY DESIGN: A cross-sectional study of pregnancy events was performed with information from the Duk ... Full text Link to item Cite

Double occupancy.

Journal article Am J Obstet Gynecol · February 2007 Featured Publication Full text Link to item Cite

Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila.

Journal article Development · January 2006 Featured Publication During metamorphosis, the reorganization of the nervous system of Drosophila melanogaster proceeds in part through remodeling of larval neurons. In this study, we used in-vitro imaging techniques and immunocytochemistry to track the remodeling of the thora ... Full text Link to item Cite

Preventability of pregnancy-related deaths: results of a state-wide review.

Journal article Obstet Gynecol · December 2005 Featured Publication OBJECTIVE: Although the risk of death from complications of pregnancy in the 20th century has decreased dramatically, several lines of evidence suggest that it has not reached an irreducible minimum. To further reduce pregnancy-related mortality, we must u ... Full text Link to item Cite

A multicenter study to determine motivating factors for residents pursuing obstetrics and gynecology.

Journal article Am J Obstet Gynecol · November 2005 Featured Publication OBJECTIVE: This study was undertaken to determine why residents choose obstetrics and gynecology. STUDY DESIGN: Applicants to obstetrics and gynecology residency programs were surveyed; a 5-point scale (5 = most important) was used to rate various aspects ... Full text Link to item Cite

Clinical evaluation of affirm VPIII in the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species in vaginitis/vaginosis.

Journal article Infect Dis Obstet Gynecol · 2004 Featured Publication OBJECTIVE: To compare the Affirm VPIII Microbial Identification Test for detection and identification of Candida species, Gardnerella vaginalis and Trichomonas vaginalis to clinical and microscopic criteria commonly used to diagnose vaginitis. METHODS: Wom ... Full text Link to item Cite

Pulmonary embolism in pregnant patients: fetal radiation dose with helical CT.

Journal article Radiology · August 2002 Featured Publication PURPOSE: To calculate mean fetal radiation dose from helical chest computed tomography (CT) by using maternal-fetal geometries obtained from healthy pregnant women and to compare the calculated CT doses with the fetal doses reported with scintigraphy. MATE ... Full text Link to item Cite

Outcome of infants delivered between 24 and 28 weeks' gestation in women with severe pre-eclampsia.

Journal article J Matern Fetal Med · October 2001 Featured Publication OBJECTIVE: To determine whether there are differences in neonatal outcome between infants born to mothers with severe pre-eclampsia and those born to normotensive mothers with preterm labor and intact membranes between 24 and 28 weeks' gestation. MATERIALS ... Full text Link to item Cite

Evaluation of the Affirm Ambient Temperature Transport System for the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species from vaginal fluid specimens.

Journal article J Clin Microbiol · September 2001 Featured Publication The objective of this study was to measure the performance of the Affirm Ambient Temperature Transport System (ATTS) over time and to estimate the length of time the system can preserve a vaginal specimen containing the three common organisms causing vagin ... Full text Link to item Cite

Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium.

Journal article Am J Obstet Gynecol · December 2000 Featured Publication OBJECTIVE: The aim of this study was to compare the distributions of protein kinase C isozymes in human nonpregnant and pregnant myometrial tissues and primary cell cultures. STUDY DESIGN: Myometrial tissues were obtained at hysterectomy from nonpregnant w ... Full text Link to item Cite

Quantitation of the five forms of plasma high molecular weight angiotensinogen in women with pregnancy-induced hypertension.

Journal article Am J Hypertens · March 2000 Featured Publication In the human pregnant state a high molecular weight form of angiotensinogen (HMrA) is present in significant quantities in addition to the usual low molecular weight angiotensinogen (LMrA). In a previous study involving a small number of white women, it wa ... Full text Link to item Cite

A randomized comparison of home uterine activity monitoring in the outpatient management of women treated for preterm labor.

Journal article Am J Obstet Gynecol · April 1999 Featured Publication OBJECTIVE: The aim of the study was to evaluate home uterine activity monitoring as an intervention in reducing the rate of preterm birth among women treated for preterm labor. STUDY DESIGN: A total of 186 women were treated in the hospital with magnesium ... Full text Link to item Cite

Effect of cocaine on intracellular calcium regulation in myometrium from pregnant women.

Journal article J Soc Gynecol Investig · 1999 Featured Publication OBJECTIVE: To evaluate the effect of cocaine on intracellular free calcium ([Ca2+]i) regulation in human myometrial cells by determining the sources of Ca2+ it might mobilize, as well as assess the role cocaine might play in the catecholamine's effect on t ... Full text Link to item Cite

Outcome of patients undergoing transabdominal cerclage: a descriptive study.

Journal article J Matern Fetal Med · 1999 Featured Publication OBJECTIVE: Transabdominal cerclage is now evolving as an alternative to transvaginal cerclage in patients with cervical incompetence. The purpose of our study was to evaluate and describe our experience in patients selected to undergo transabdominal cercla ... Full text Link to item Cite

Localization of a baculovirus-induced chitinase in the insect cell endoplasmic reticulum.

Journal article J Virol · December 1998 Featured Publication Confocal immunofluorescence microscopy was used to demonstrate that the Autographa californica nucleopolyhedrovirus (AcMNPV) chitinase was localized within the endoplasmic reticulum (ER) of virus-infected insect cells. This was consistent with removal of t ... Full text Link to item Cite

Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?

Journal article Am J Obstet Gynecol · November 1998 Featured Publication OBJECTIVE: Our purpose was to determine whether the continuation of antibiotics postoperatively after cesarean section in patients whose labors were complicated by chorioamnionitis would reduce the incidence of endometritis. STUDY DESIGN: Patients with a c ... Full text Link to item Cite

Anticoagulation.

Journal article Clin Obstet Gynecol · September 1998 Featured Publication Outpatient management of women requiring treatment and prophylaxis against thromboembolic conditions during pregnancy and the postpartum period requires a coordinated effort between the patient, her obstetrician and, in certain cases, a hematologic consult ... Full text Link to item Cite

Methadone maintenance in pregnancy: a reappraisal.

Journal article Am J Obstet Gynecol · August 1998 Featured Publication OBJECTIVE: The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy. STUDY DESIGN: Thirty-two pregnancies in women receiving methadone maintenance were matched by gestational age to women with a positive urine screen ... Full text Link to item Cite

Cytomegalovirus infection.

Journal article Semin Perinatol · August 1998 Featured Publication Cytomegalovirus (CMV) infection is the most common perinatal infection and may result in severe injury to the fetus. Forty percent to 50% of infants delivered to mothers with primary CMV will have congenital infections. Of these, 5% to 18% will be overtly ... Full text Link to item Cite

The impact of prenatal care coordination on birth outcome.

Journal article Prim Care Update Ob Gyns · July 1, 1998 Featured Publication Objective: Care coordination is a Medicaid benefit program designed to assist low-income women in gaining access to pregnancy related services. This study examines the relationship between prenatal care coordination and its impact on access to prenatal ser ... Full text Link to item Cite

The association of aneuploidy and unexplained elevated maternal serum alpha-fetoprotein.

Journal article J Perinatol · 1998 Featured Publication OBJECTIVE: The purpose of this study was to examine fetal chromosomal abnormalities in pregnancies complicated by unexplained elevated maternal serum alpha-fetoprotein (MSAFP). STUDY DESIGN: We reviewed, using a computerized database, 58,162 obstetrical ul ... Link to item Cite

Tocolytic treatment for preterm contractions with and without cervical changes.

Journal article Am J Perinatol · August 1997 Featured Publication Our purpose was to evaluate the impact of intravenous and oral tocolysis on prolongation of gestation for women with preterm uterine contractions and/or labor. Candidates for evaluation and treatment including women with contractions between 24 and 35 week ... Full text Link to item Cite

Cervical prolapse complicating pregnancy.

Journal article J Natl Med Assoc · May 1997 Featured Publication Uterine cervical prolapse concurrent with pregnancy is rare. This article reports three cases of second-degree cervical prolapse during pregnancy. Two women developed prolapse in the late second trimester while one women had preexisting prolapse. Both wome ... Link to item Cite

Cervical ripening: randomized comparison of intravaginal prostaglandin E2 gel with prostaglandin E2 gel plus laminaria tents.

Journal article J Matern Fetal Med · 1997 Featured Publication The purpose of this study was to evaluate the efficacy of adding laminaria tents to sequential intravaginal prostaglandin E2 (PGE2) gel for cervical ripening. A prospective, randomized study was conducted from October 1994 to May 1995. Pregnant women with ... Full text Link to item Cite

Umbilical cord thiocyanate and thyroid function in intrauterine growth-restricted infants of the smoking gravida.

Journal article J Perinatol · 1997 Featured Publication OBJECTIVE: We evaluated maternal and umbilical cord thiocyanate and thyroid function in intrauterine growth-restricted infants of smoking mothers. STUDY DESIGN: One hundred six mother-infant pairs were studied and divided into four groups: smokers with app ... Link to item Cite

The impact of the Women, Infants and Children Food Supplement Program on birth outcome.

Journal article Am J Obstet Gynecol · April 1996 Featured Publication OBJECTIVE: Our purpose was to compare the birth outcomes of pregnant women in the Women, Infants and Children Food Supplement Program with women not in the program. STUDY DESIGN: The vital records of 4713 women, 2895 enrolled in the Women, Infants and Chil ... Full text Link to item Cite

Deep venous thrombosis and pulmonary embolism.

Journal article Clin Obstet Gynecol · March 1996 Featured Publication Full text Link to item Cite

Effect of magnesium on fetal heart rate variability using computer analysis.

Journal article Am J Perinatol · July 1995 Featured Publication We studied 16 women, at 32 weeks' or more gestation who required magnesium sulfate (MgSO4) therapy for preterm labor or preeclampsia. A 60-minute Doppler fetal heart rate (FHR) tracing, analyzed by the Oxford Sonicaid System 8000, was obtained for 1 hour b ... Full text Link to item Cite

Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age.

Journal article Transfusion · July 1995 Featured Publication BACKGROUND: Cord blood has been used for transplantation. The purpose of this study was to compare numbers of hematopoietic progenitors in cord blood collected from neonatal infants who are small for their gestational age and those who are normal. STUDY DE ... Full text Link to item Cite

Antiphospholipid antibodies and recurrent pregnancy loss.

Journal article Clin Obstet Gynecol · March 1991 Featured Publication Women with antiphospholipid antibodies have a significant risk of reproductive failure and adverse pregnancy outcomes. The incidence of recurrent abortion, fetal death, and intrauterine fetal growth retardation is significant. Women with a history of recur ... Full text Link to item Cite

Anticardiolipin antibodies in unselected pregnant women. Relationship to fetal outcome.

Journal article J Perinatol · March 1991 Featured Publication Anticardiolipin antibodies (ACLA) have recently been associated with adverse fetal outcome. The prevalence of elevated ACLA has not been studied in unselected pregnant women, however. Twelve hundred unselected pregnant women were screened for IgG ACLA usin ... Link to item Cite

Obstetric complications in young teenagers.

Journal article South Med J · January 1991 Featured Publication We compared pregnancy outcome in 286 teenaged primigravidas (less than or equal to 16 years old) and 267 adult primigravidas (21 to 25 years old) who had similar prenatal care, socioeconomic status, and racial balance. The incidence of preterm labor and de ... Full text Link to item Cite

Clinical chorioamnionitis is not predicted by an ultrasonic biophysical profile in patients with premature rupture of membranes.

Journal article Obstet Gynecol · December 1990 Featured Publication A modified biophysical profile was assessed serially in 47 patients with premature rupture of membranes who were not in labor. This profile included fetal movement, fetal tone, fetal breathing, amniotic fluid volume, and placental grade. The most recent st ... Link to item Cite

Umbilical cord blood gas assessment of twins.

Journal article Obstet Gynecol · May 1990 Featured Publication Umbilical cord arterial and venous blood gas values were compared in 63 twin pairs, of which 57 pairs had birth weights of 1500 g or more each. Small differences between the first and second twins existed for PO2, PCO2, and pH. However, bicarbonate values ... Link to item Cite

Umbilical cord blood gases for term healthy newborns.

Journal article Am J Perinatol · April 1990 Featured Publication Examination of paired umbilical arterial and umbilical venous blood gases for 147 term, healthy newborns revealed a strong correlation of pH, bicarbonate, and base excess with the 1-minute Apgar score. Although significantly different from each other, a st ... Full text Link to item Cite

Strategic planning.

Journal article AAOHN J · July 1989 Featured Publication Link to item Cite

Estimating fetal weight in patients with preterm premature rupture of the membranes.

Journal article Am J Obstet Gynecol · May 1989 Featured Publication Fetal weight estimation was performed in 58 women with preterm premature rupture of the membranes within 4 days of delivery. Of twelve formulas evaluated, only two met the requirements for clinical use (i.e., they had a small mean percent error and a high ... Full text Link to item Cite

Fetal anthropometry at term: effect of menstrual age and relative fetal size.

Journal article J Clin Ultrasound · 1989 Featured Publication In a study of 324 term pregnancies, fetal measurements (biparietal diameter, femur length, and abdominal diameter) obtained within one week of delivery correlated more strongly with relative birth weight than with menstrual age. ... Full text Link to item Cite

In utero growth of the large-for-menstrual-age fetus.

Journal article J Clin Ultrasound · January 1989 Featured Publication In a cross-sectional study of 87 large-for-menstrual-age term infants, intrauterine growth was found to be linear, 34 g per day. Differences between diabetic and nondiabetic pregnancies were not evident. ... Full text Link to item Cite

Ultrasonographic identification of the macrosomic fetus.

Journal article Am J Obstet Gynecol · November 1988 Featured Publication Ultrasonographically determined biparietal diameter, femur length, abdominal circumference, and estimated fetal weight were analyzed with regard to their ability to predict the macrosomic newborn. Receiver operating characteristic curves were plotted for e ... Full text Link to item Cite

Fetal weight estimates in diabetic gravid women.

Journal article J Clin Ultrasound · October 1988 Featured Publication Fetal weight in utero was estimated sonographically within one week of delivery in 70 live-born fetuses of diabetic gravidas. The best estimates of weight were obtained with formulas dependent on biparietal diameter, abdominal circumference, and femur diap ... Full text Link to item Cite

Fetal overgrowth. Diabetic versus nondiabetic.

Journal article J Ultrasound Med · October 1988 Featured Publication Term, large for gestational aged newborns were retrospectively evaluated. The fetal parameter of relative growth, was measured using the ratio of fetal length to abdominal circumference (FL/AC). This measurement was not different between diabetic and nondi ... Full text Link to item Cite

Premature placental calcification in maternal cigarette smokers.

Journal article Obstet Gynecol · June 1988 Featured Publication Ultrasonographic examinations, including placental grading, were done in 145 smoking and 100 nonsmoking low-risk obstetric patients at 37 weeks' gestation. Extensive calcification--grade III changes--occurred significantly more often in smokers than in non ... Link to item Cite

Estimated fetal weight: applicability to small- and large-for-gestational-age fetus.

Journal article J Clin Ultrasound · February 1988 Featured Publication Ultrasonic formulas using femur length and abdominal circumference with or without biparietal diameter were found to be highly accurate in predicting the weight of normal-sized term infants. The small-for-gestational age fetus, however, was overestimated a ... Full text Link to item Cite

The relationship of placental grade to fetal size and growth at term.

Journal article Am J Perinatol · January 1988 Featured Publication Among 246 term patients undergoing ultrasonic evaluation within 1 week of delivery, a grade-three placenta was found in 39.4%. Advanced placental maturity was not associated with altered fetal growth rates or an increase in small- or large-for-gestational ... Full text Link to item Cite

Ultrasonic recognition of the small-for-gestational-age fetus.

Journal article Obstet Gynecol · April 1987 Featured Publication Sonar biparietal diameter, femur length, abdominal circumference, femur length/abdominal circumference ratio, ponderal index, and estimated fetal weight were obtained within ten days of delivery of small-for-gestational-age (SGA) (N = 102) and non-SGA (N = ... Link to item Cite

Recognition of the overgrown fetus: in utero ponderal indices.

Journal article Am J Perinatol · April 1987 Featured Publication In a cross-sectional study of 210 pregnancies resulting in above-average-sized term infants, ponderal and ponderal-like indices were found to be highly correlative with fetal overgrowth. Clinical usefulness, however, is limited because for each index, most ... Full text Link to item Cite

Plasma and amniotic fluid prostacyclin and thromboxane in mild pregnancy-induced hypertension.

Journal article Am J Perinatol · April 1987 Featured Publication To study the involvement of 6 keto prostaglandin F1 alpha (6 keto PGF1 alpha) and thromboxane B2 (TxB2) in mild pregnancy-induced hypertension (PIH), we measured amniotic fluid and plasma concentration of these prostanoids by radioimmunoassay in PIH subjec ... Full text Link to item Cite

A cross-sectional study of in utero growth of the above average sized fetus.

Journal article Am J Obstet Gynecol · November 1986 Featured Publication In a cross-sectional study of 210 pregnancies resulting in above-average-sized term infants, biparietal diameter, femur length, and abdominal circumference were found to differ among three birth weight percentile groups (greater than 90, 76 to 90, and 51 t ... Full text Link to item Cite