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You-Wen He

Professor of Integrative Immunobiology
Integrative Immunobiology
Box 3010 DUMC, 335 Jones Building, Durham, NC 27710
335 Jones Building, 207 Resear, Box 3010 DUMC, Durham, NC 27710

Selected Grants


Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Basic Immunology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

The Effect of a Desensitization Protocol in Highly Sensitized Renal Transplant Recipients on T Follicular Helper Cells

FellowshipCollaborator · Awarded by National Institutes of Health · 2023 - 2024

A Novel Immune Modulating Antibody for the Treatment of Lung Cancer

ResearchPrincipal Investigator · Awarded by Department of Defense · 2019 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Basic Immunology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

The Effect of a Desensitization Protocol in Highly Sensitized Renal Transplant Recipients on T Follicular Helper Cells

FellowshipCollaborator · Awarded by National Institutes of Health · 2023 - 2024

A Novel Immune Modulating Antibody for the Treatment of Lung Cancer

ResearchPrincipal Investigator · Awarded by Department of Defense · 2019 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

T cell receptor-activated autophagy as a regulator of T cell effector responses

ResearchPrincipal Investigator · Awarded by Henry M. Jackson Foundation · 2017 - 2022

The impact of genetic diversity among Akkermansia strains on the effectivenes of immune checkpoint inhibitors in cancer immunotherapies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2020 - 2022

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Quinolizidines as Novel HIV-1 Entry Inhibitors

ResearchCo Investigator · Awarded by National Institutes of Health · 2016 - 2018

Regulation of T cell exhaustion by microRNA-720

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017

Training Program in Inflammatory and Immunological Diseases

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1980 - 2017

Validation of a microRNA signature for the prediction, diagnosis and prognosis of acute graft-versus-host disease

ResearchPrincipal Investigator · Awarded by Blood and Marrow Transplant Clinical Trials Network · 2015 - 2015

Plasma microRNAs as non-invasive biomarker for acute graft-versus-host diseases

ResearchPrincipal Investigator · Awarded by The Biomarker Factory · 2014 - 2015

Autophagy in T lymphocyte function

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2015

BcI-2 family in T lymphocyte homeostasis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2014

Regulation of thymocyte maturation and mature T lymphocyte homeostasis by c-FLIP

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2013

The effects of Nlrp12 and IL-1b in inflammatory disorders

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2012

A novel pathway regulating cytokine production and asthma development

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2011

Function of thymic epithelial cells in T lymphocyte maturation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2011

Extracellular Matrix Protein in Innate Immunity

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2008

Pattern Recognition Molecule Mindin As Adjuvant

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2008

Orphan Nuclear Receptor in Thymocyte Differentiation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007

External Relationships


  • Beijing Tricision Biotherapeutics Inc.
  • Frontier in Cell and Developmental Biology Journal
  • TriVac Inc.

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.