Scholars@Duke
Heath Gasier

Heath Gasier

Associate Professor in Anesthesiology
Anesthesiology
heath.gasier@duke.edu
DUMC 3823, 40 Medicine Circle, Durham, NC 27710
Center for Hyperbaric Medicine, & Environmental Physiology, DUMC 3823 Durham, NC 27710
Office hours Monday-Friday, 8:30 am - 5:00 pm  

Scholarly Works - Conferences

Impact of Sarcopenic Obesity on Pulmonary Responses to Hyperoxia

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractBackground: Sarcopenic obesity (SO) is the coexistence of reduced muscle mass and function that occurs in aging and excess body fat. SO is linked to a higher incidence of lung disease than obesity ... Full text Cite

Paraoxonase 2 Mitigates Mitochondrial Oxidative Stress in Airway Epithelial Cells

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2024 Link to item Cite

Effect of Dietary Cholesterol on Muscle Hypertrophy with Resistance Training

Conference Medicine & Science in Sports & Exercise · May 2007 Full text Cite

Dietary Cholesterol Alters Recovery from Eccentric Muscle Damage in Humans

Conference Medicine & Science in Sports & Exercise · May 2006 Full text Cite

S-Nitrosoglutathione Reductase Null Mice Display Increased Brain Glutamic Acid Decarboxylase Activity and Seizure Resistance in Hyperbaric Oxygen

Conference An imbalance between glutamatergic and g-aminobutyric acid (GABA)ergic synaptic transmission is associated with hyperbaric oxygen (HBO2) induced seizures. Here we explored the impact of S-nitrosylation in preventing oxygen toxicity in S-nitrosoglutathione ... Link to item Cite

The beneficial effects of low-dose carbon monoxide and moderate intensity endurance exercise on metabolic and skeletal properties

Conference Carbon monoxide (CO) is released with Fe2+upon heme degradation to biliverdin, a reaction catalyzed by heme oxygenase. CO is a metabolic gas with known beneficial metabolic properties, most notably asa potent stimulator of mitochondrial biogenesis. Moreove ... Link to item Cite

The assessment of in vivo protein synthesis following chronic resistance exercise using 2H2O

Conference Protein synthesis (PS) in rats is preferentially assessed using labeled amino acids over a short period of time. We previously observed in our lab (unpublished) that 15 resistance exercise (RE) sessions over 5 weeks stimulated hypertrophy, but not PS when ... Cite

Plateau effects of resistance exercise result from over-expression of eIF4E-BP1

Conference Resistance exercise (RE) training may lead to a ‘plateau effect’; whereby muscle protein synthesis is not elevated post exercise. We observed during previous studies in our lab (unpublished) that 15 RE sessions over 5 weeks leads to muscle hypertrophy in r ... Link to item Cite

Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees

Conference BACKGROUND: Vitamin D has been implicated in modulating innate immunity and may confer protection against upper respiratory tract infections (URTIs) during periods of arduous training. PURPOSE: Determine whether vitamin D status in Marine Corps basic train ... Full text Link to item Cite

The effects of dietary cholesterol and resistance training on lean mass change and cholesterol metabolism in rat skeletal muscle

Conference Resistance exercise (RE) training is a potent stimulus of muscle growth, and recent evidence suggests that cholesterol (CL) may augment this process. Moreover, CL may influence sterol regulatory element binding protein-2 (SREBP-2), which is the master regu ... Link to item Cite

Effects of 5-Hydroxymethyl-2-Furfural (5-HMF) on Skeletal Muscle Performance in Rats Exposed to an Acute Bout of Hypobaric Hypoxia

Conference Exposure to high altitude is associated with a reduction in the partial pressure of oxygen (PO2) that subsequently affects all components of the oxygen transport cascade, from lung to mitochondria. Impaired oxygen transport contributes to decrements in exe ... Link to item Cite

Does Post Exercise Protein Reduce Total Protein Needs for Optimal Skeletal Muscle Responses to Resistance Training in Older Adults?

Conference Purpose: Age-related muscle and strength loss, Sarcopenia, is a significant problem in the elderly population but may be restored through adequate protein intake and resistance exercise training (RET). The amount and timing of protein consumption may poten ... Link to item Cite

Does Dietary Cholesterol Increase Cardiovascular Risk in Exercising People? A Randomized Placebo-Controlled Trial

Conference Background: There is no clear evidence that dietary cholesterol increases cardiovascular risk (CVR), likely due to the lack of control for physical activity. We hypothesized in the presence of a standardized exercise program that varying dietary cholestero ... Link to item Cite

Dietary Cholesterol and Skeletal Muscle Hypertrophy with Resistance Training: A Randomized Placebo-Controlled Trial

Conference Background:We recently reported a strong positive association of dietary cholesterol and skeletal muscle responses to resistance training (Riechman, 2007). To confirm these findings we conducted a randomized placebo controlled trial in which we supplemente ... Link to item Cite

Static And Dynamic Grip Endurance At Altitude Is Not Affected By Acute Oral Sodium Nitrate Supplementation

Conference There is increasing evidence that dietary nitrate (NO3-) supplementation improves exercise efficiency and performance. As the conversion of NO3- to nitrite to nitric oxide is facilitated by hypoxic and acidic conditions, NO3- supplementation may provide a ... Full text Link to item Cite

Elevations in myofibrillar protein fractional synthesis rates following 5-weeks of dynamic resistance exercise

Conference Anabolic responses to a single bout of high intensity exercise are elevated, but these responses appear to be diminished with chronic training. PURPOSE: To determine the effects of resistance exercise (RE) training on cumulative (36 hour) fractional synthe ... Full text Link to item Cite